Digital Commons Network^™

Forecasting Bike Rental Demand Using New York Citi Bike Data, Wen Wang

Dissertations

The idea of this project is from a Kaggle competition “Bike Sharing Demand”① which provides dataset of Capital Bikeshare in Washington D.C. and asked to combine historical usage patterns with weather data in order to forecast bike rental demand. This dissertation will extend this work, working with a broader range of project not only just focusing on the phrase of model building but all phases of KDD (Knowledge Discovery in Databases). This dissertation focuses on Citi Bike which is one of the biggest bike share projects in the world, collects Citi Bike data, weather data and holiday data from three …

An Evaluation Of Gamification To Assess Students’ Learning On Their Understanding Of First Year Computer Science Programming Module, Daniel Gebremichael

Dissertations

This research examines the use of gamification to develop an assessment tool, to assess students’ learning of a first year computer science module. The students’ undertaking of the first semester Programming and Algorithms module in 2015 were assessed on their knowledge of the programming language Python. The incorporation of gamification when assessing students can have various potential benefits. The research aims to identify these benefits and issues. Assessments and games have almost opposite effects on opinions on people, as games are usually expected to have an entertainment value but this is not the case for assessments. The research examines if …

Missouri Public School Administrators’ Perceived Effectiveness Of Senate Bill No. 75, Joby B. Steele

Dissertations

In this quantitative study, the perceptions of safety and preparedness of Missouri’s high school administrators after participating in active shooter training as mandated by Missouri’s Senate Bill No. 75 were analyzed. As school shootings continue, states have passed legislation to prepare schools to provide safety for students and faculty members (Shah, 2013b). There are currently limited data about the perceived effectiveness of Missouri’s Senate Bill No. 75 and its ability to help administrators feel safe and prepared in the event of an active shooter. This study involved examination of what schools can do to prepare for a school shooting before …

Monocyte-Induced Regulatory T Cell Differentiation, Jessica Genevieve Lee

Dissertations

Immediately after birth, thousands of foreign antigens challenge the newborn immune system. Many of the invaders are harmless, such as food, pollen, and beneficial bacteria. Newborns have a tolerant immune system that keeps them from developing inflammation or allergies to these new antigens. In utero, this immunoregulatory tendency is important for establishing tolerance to self and maternal antigens. Multiple processes contribute to fetal tolerance, including clonal deletion, anergy, changes in antigen presenting cells (APCs), and the generation of regulatory T cells (Tregs). However, the mechanism(s) of fetal Treg differentiation and the specific APCs required are unknown.

Our lab has previously …

Coping With Trauma: Reflections From Angolan Refugee Returnees, Michael Robert Milco

Dissertations

Millions of refugee families experience multiple migrations resulting in various degrees of trauma and stress. Each reacts to these challenges and hardships in unique ways. This dissertation research was designed to investigate the various coping strategies Angolan refugee returnees used in dealing with the traumas they experienced as a result of their various migrations. Through the lens of an ecosystem theory, the author developed research questions designed to learn “How Angolan Refugee Returnees Cope with Trauma?” Sixteen Angolan refugee returnees were interviewed in this qualitative phenomenological study. The results of the study narrowed down the most specific themes refugees used …

The Impact Of Altered T Cell Receptor—Peptide-Major Histocompatibility Complex Interactions On Antigen Recognition And T Cell Function, Timothy T. Spear

Dissertations

Adoptive cell transfer (ACT) using T cell receptor (TCR) gene-modified T cells is an exciting and rapidly evolving field. Numerous basic science and clinical studies have demonstrated various levels of feasibility, safety, and efficacy using TCR-engineered T cells to treat cancer and viral infections. Genomic instability of targeted diseases, however, requires effective and safe TCRs to cross-recognize mutated antigens while minimizing on- or off-target toxicities. Thus, improvements to T cell-based therapeutics mandate a broader understanding of the principles governing antigen recognition. This dissertation addresses critical biologic questions evaluating which parameters are most important in facilitating antigen recognition, and how alterations …

Consequences Of Estrogen Receptor Beta Phosphorylation In The Aged Female Brain And Heart, Elena Pinceti

Dissertations

Female life expectancy in the United States has steadily increased and now averages 81 years. Meanwhile, the age at which women reach menopause remains constant at 51 years. Both neurological and cardiovascular disorders increase following menopause, affecting women’s quality of life and leading to large health care costs. Estrogens are neuroprotective and cardioprotective for women, however when administered long after menopause, they fail to improve their health.

The effects of estrogen are mediated by Estrogen Receptor α (ERα) and Estrogen Receptor β (ERβ). Evidence supports that ERβ plays an important role in neuroprotection and cardioprotection, but aspects of ERβ molecular …

The Seat Of Justice In The House Of Love: Toward An Ecclesial Theory Of Justice, James Grant Gholson

Dissertations

ABSTRACT

This dissertation is an extension of the ongoing conversation about justice within Christian ethics from a postliberal perspective. Beginning with an account of Christian ethical methodology centered on the grammar of the Christian “language-game” that is both shaped by, and which mediates, the communal reading of scripture, the dissertation argues that Christian discipleship, as a teleological enterprise governed by the normativity of the life, death, and resurrection of Jesus, consists in the communal representation of Christ’s own faithfulness to God as a public witness over against the reign of the “principalities and powers” of the world. Applying Iris Marion …

The Role Of Microrna In Cardioprotection: Ischemic Preconditioning And Mesenchymal Stem Cell Paracrine Effects, Kristin Luther

Dissertations

Changes in gene expression and protein levels are an important aspect of cardioprotection in which short non-coding RNA known as miRNA may play a key regulatory role. We investigated the functions of several miRNAs in the context of two cardioprotective stimuli, ischemic preconditioning (IPC) and mesenchymal stem cell (MSC) paracrine effects. We hypothesized that downregulation of a set of miRNAs (miR-148a/b, miR-30b, and let-7a*) augments expression of protective heat shock proteins during IPC, and that MSC exosomes transfer miR-21 to cardiomyocytes, resulting in downregulation of pro-apoptotic genes and reduction of infarct size.

IPC increased the level of Hsp70, Hsp90, and …

The Amino Terminal Region Of Cardiac Myosin Binding Protein-C Is Necessary For Cardiac Function, Thomas Lawrence Lynch

Dissertations

Cardiac myosin binding protein-C (cMyBP-C) is a thick filament-associated protein that has been suggested to regulate cardiac contraction via its amino terminal (N’) region. Following ischemic injury to the heart, cMyBP-C is cleaved into a predominant N’ fragment consisting of domains C0 through C1 and the first 17 residues of the M-domain that is referred to as C0-C1f. However, the necessity of the N’-C0-C1f region of cMyBP-C in regulating cardiac function in vivo has not been elucidated. I hypothesized that the N’-C0-C1f region of cMyBP-C is critical for normal cardiac function in vivo. To test this hypothesis, transgenic (TG) mice …

Use Of Video Games In Patients' Self-Management Of Pain: A Feasibility Study, Janet Donnelly Phd(C), Rn-Bc, Acns-Bc, Pccn

Dissertations

Background: Pain affects more than 75 million Americans and is the primary reason people seek medical attention. Pain is a common cause of disability and diminished quality of life. While anecdotal evidence exists regarding nurses’ use of distraction therapy activities in pain management, little empirical research data is available.

Purpose: To examine the effects of video game use (VGU) on pain perception, pain interference perception and perceived self-efficacy in pain management in adult inpatients.

Conceptual Model: The conceptual model is based on Self-efficacy Theory (Bandura, 1995). The antecedents of the concept of distraction therapy with use of VGs in patients’ …

Deposition And Characterization Of Hermetic, Biocompatible Thin Film Coatings For Implantable, Electrically Active Devices, Robyn K. Sweitzer

Dissertations

Retinal prostheses may be used to support patients suffering from Age-related macular degeneration or retinitis pigmentosa. A hermetic encapsulation of the poly(imide )-based prosthesis is important in order to prevent the leakage of water and ions into the electric circuitry embedded in the poly(imide) matrix. The deposition of amorphous aluminum oxide (by sputtering) and diamond like carbon (by pulsed laser ablation and vacuum arc vapor deposition) were studied for the application in retinal prostheses. The resulting thin films were characterized for composition, thickness, adhesion and smoothness by scanning electron microscopy-energy dispersive spectroscopy, atomic force microscopy, profilometry and light microscopy. Electrical …

Using High-Fidelity Medical Simulation To Assess Critical Thinking In Medical Students, Lynda Daniel-Underwood

Dissertations

Problem

Graduating competent physicians is an imperative societal need. The development of critical thinking skills during medical school is important to meet this societal need and for the care of ill patients. Research shows this skill is key in decreasing medical errors, which in turn decreases cost. (Norman and Eva, 2010) Missing from the literature is a method to assess critical thinking in the setting of caring for the critically ill patient. This instrumental case study tests medical simulation as a method of assessing critical thinking, which incorporates all six competency domains, by looking at the assessment environment, summative patient …

An Exploration Of Attachment, Trauma, And Treatment Outcome In A Cognative Behaviorable Therapy-Based Group Anger Management Program: A Multiple Case Study, Cynthia K. Swope

Dissertations

This study explored the relationship between trauma, attachment styles, and treatment outcomes among violent offenders attending a group cognitive behavioral therapy (CBT)-based anger management program. Using a mixed method, multiple case study design, the researcher examined the individual experiences of seven individuals court-mandated to attend a community-based anger management program. Semi-structured interviews were utilized to develop the participant narratives used in the qualitative analyses. Participant scores on the Adverse Childhood Experiences (ACE) Questionnaire, the Experience in Close Relationships (ECR-R) Questionnaire, and the Novaco Anger Scale (NAS) provided quantitative measures of trauma history, attachment style, and anger disposition. The results of …

Robust Support Media For High Throughput Chromatographic Separations, Javier Sanchez Santiago

Dissertations

Affinity chromatography is used to separate biomolecules based on highly specific interactions, such as receptor and ligand, enzyme and substrate or antigen and antibody. Traditional chromatographic separation systems have the disadvantages of low flowrates, high pressure drop across the column, low capacity and poor reusability. Ceramic monoliths have been previously used as active support for affinity chromatographic columns due to their compact geometry and outstanding mechanical properties. In addition, mathematical models have been developed in order to determine the adsorption and elution times depending on the monolith geometry. The reversible interaction between L-asparagine and L-asparaginase has been exploited, using a …

“But Who, We?”: Derrida On Non-Human Others, Thomas Helmut Bretz

Dissertations

In this dissertation I establish the possibility of social and ethical relationships with non-human natural (and in particular inanimate) beings. I do so based on the work of 20th century French philosopher Jacques Derrida. In chapter 1 I discuss the relatively sparse secondary literature that addresses the intersection between Derrida's work and environmental philosophy. I also go over some textual indications that show that Derrida has been concerned with non-human beings throughout his career.

In chapters 2 and 3 I establish the impossibility of conclusively excluding any kind of being from the purview of ethical responsibility. While chapter 2 develops …

Sex Differences In Stroke Recovery: Synaptic Proteins And The Growth Inhibitory Protein Nogo A, Vincent Joseph Borkowski

Dissertations

Ischemic stroke is a major world-wide health problem, resulting in death and disability especially in the older population. A sex difference exists in functional recovery post-stroke, with post-menopausal women having worse functional outcome as compared to age-matched men. Although the mechanisms underlying this sex difference are not entirely clear, it is recommended that any potential therapy for stroke recovery be tested in pre-clinical models including both male and females in order to determine the efficacy of the proposed treatment on the entire population. We have reported a novel therapy to enhance brain plasticity and improve functional recovery after stroke in …

The Role Of Foxo Transcription Factors In Alcohol-Induced Deficient Fracture Repair, Philip M. Roper

Dissertations

Proper and complete repair of a bone fracture is essential in quality of life maintenance, but poor healing and fracture malunion are still medically and socially relevant problems. Alcohol abuse impairs normal fracture healing, leading to delayed or incomplete union. This dissertation aims to clarify mechanisms behind this alcohol-induced impaired healing, thereby elucidating potential methods of intervention.

Alcohol-induced oxidative stress has been linked to many morbidities associated with alcohol abuse. This dissertation elucidates a potential mechanism through which alcohol inhibits fracture healing by increasing oxidative stress. Using a rodent model, I found that alcohol exposure decreases fracture callus formation and …

Neural Correlates Of Political Attitudes: Emotion And Ideology In The Brain, Dane Gorman Wendell

Dissertations

Do conservatives and liberals have differing sensitivities to avoidance, inhibition, and negative emotion? Do psychological factors beneath our conscious awareness underlie the political ideologies we embrace? Political science researchers have broken new ground over the past ten years in our understanding of the psychology and physiology of political ideology. However, large questions remain about how political ideology may be related to avoidance motivations and negative emotion. This work expands our current knowledge in this area by presenting three studies with multiple methodologies: original survey data, electroencephalographic measurements, and behavioral experiments in a lab setting. Working in the tradition of J.A. …

Characterization Of Ubiquitin-Proteasome Dynamics In Caenorhabditis Elegans Muscle Cells During Protein-Folding Stress, Gregory A. Skibinski

Dissertations

In order to adapt to changing conditions and life stages, cells must remodel the composition of the proteome by specifically removing obsolete or damaged proteins. Failure to remove proteins at the appropriate time can cause a variety of cellular dysfunctions that can lead to cell death and conditions such as cancer, Huntington's, Parkinson's and Alzheimer's disease. Protein quality control is especially important during aging and stress, as the accumulating load of damaged, misfolded, and aggregated proteins can overwhelm the cell's ability to maintain the proteome. The ubiquitin-proteasome system is responsible for the specific degradation of many proteins within eukaryotic cells. …

Justice, Cult, And Salvation In Isaiah 56-59: A Literary-Theological Study, Hudyard Y. Muskita

Dissertations

The main focus of this dissertation is the interconnection among the themes of justice, cult, and salvation in Isaiah 56-59. The investigation will analyze and explore the theological importance of these themes, which include questions such as, What are the descriptions of these themes in these chapters? How are they related to each other? As divine salvation is portrayed as moving back and forth from immanence to distance several times throughout this particular section of the book of Isaiah, what factors are responsible for this dynamic? What is the role of cult and social justice in this salvation? In what …

Ain't Misbehavin': Phenomenological Inquiry Into Black Male Experiences Of School, Kelly N. Ferguson

Dissertations

Disproportionate representation of Black male students in subjective areas of discipline has long been documented. Research indicates that racial disparities in discipline have been found with insufficient evidence to support that Black or other minority students are simply misbehaving more than others. Differences in cultural orientations between Black males and their predominantly White and female teachers have been linked to bias that disproportionality impacts discipline for these students. Through phenomenological inquiry, this study explored the schooling, professional, and mentoring experiences of successful Black men to better understand how schools and communities contribute to their resilience. This research sought to uncover …

Mechanism By Which Commensal Bacteria Limit Inflammation, Mallory Paynich

Dissertations

Trillions of bacteria live within the gastrointestinal tract and are critical for maintaining intestinal homeostasis; however, the mechanisms utilized by specific bacterial molecules to contribute to homeostasis are not well understood. We utilize a mouse model in which a single oral dose of the probiotic, Bacillus subtilis, protects mice from acute colitis induced by the enteric pathogen Citrobacter rodentium. Our goal is to elucidate the mechanism by which B. subtilis prevents inflammation.

We identified exopolysaccharides (EPS) to be the active molecule of B. subtilis, and a single dose of EPS protects mice from disease. EPS binds F4/80+CD11b+ peritoneal macrophages, and …

Keeping Schools Catholic: Discipleship As Paradigm For Administrators, Teachers, Staff And Students, James (Deporres) Charles Durham

Dissertations

Of the many accomplishments of the Catholic Church in the United States, one of the most known is the Catholic School System. In 1965, over 4.4 million children were educated in the 10,667 Catholic elementary schools, and almost 700,000 in the 1,527 Catholic high schools (Center for Applied Research for the Apostolate, 2013). The mission of the school was embodied, literally, in these skilled male and female religious who taught in these schools. But the number of male and female religious was not sustained, leading to the question of how the religious mission of the school will continue. The number …

Emature: Intergenerational Networks In Digital Media Spaces, Andras Lukacs

Dissertations

While the literature on adolescent usage of the Internet and mobile communication technology is burgeoning, the technological affordance of increased intergenerational contacts and intergenerational friendships received less attention. This project documents how intergenerational virtual networks operate in one particular massively multiplayer online game (World of Warcraft) from the standpoint of adolescent players. Online social worlds are similar to offline settings in a lot of ways. Users must obey certain behavioral standards and follow established rules and moral codes to participate. Despite accounts of online democracy and networked individualism, control and authority is central to the functioning of these environments. Power-relationships …

Development Of "Inside-Out" Pegylated Crosslinked Hemoglobin Polymers: Novel Hemoglobin-Based Oxygen Carriers (Hboc), Kyle Douglas Webster

Dissertations

The development of an effective blood substitute is urgent due to increasingly common blood shortages, the need to type-match donated blood, and communicable diseases (e.g. HIV) posing risks for blood transfusions around the world. There have been many attempts at creating hemoglobin-based oxygen carriers (HBOC) using a variety of techniques centered around the use of polyethylene glycol (PEG) conjugated to hemoglobin (Hb) tetramers. A novel method, “Inside-Out” PEGylation, has been developed by our lab to produce a polyethylene glycol crosslinked hemoglobin (PEG XL-Hb) polymer. This method utilizes a single PEG backbone that is surrounded by multiple proteins, instead of covering …

Cardiac Calcium Atpase Dimerization Measured By Fluorescence Resonance Energy Transfer And Chemical Cross-Linking, Daniel Blackwell

Dissertations

The cardiac sarco/endoplasmic reticulum calcium ATPase (SERCA) establishes the intracellular calcium gradient across the sarcoplasmic reticulum membrane. It has been proposed that SERCA forms homo-oligomers that increase the catalytic rate of calcium transport. We investigated SERCA oligomerization in rabbit left ventricular myocytes using a photoactivatable cross-linker. Western blotting of cross-linked SERCA revealed higher molecular weight species consistent with SERCA oligomerization. Fluorescence resonance energy transfer (FRET) measurements in cells transiently transfected with fluorescently-labeled SERCA2a revealed that SERCA readily forms homo-dimers. These dimers formed in the absence or presence of the SERCA regulatory partner, phospholamban (PLB) and were unaltered by PLB phosphorylation …

Kant, The Natural Law, And The Question Of Normativity In Catholic Ethics, John Robert Crowley-Buck

Dissertations

This dissertation explores the question of normativity in 21st century Catholic ethical reflection. While, today, the natural law tradition frames and founds the normative question in Catholic ethics in terms of the imago Dei, this project explores the moral philosophy of Immanuel Kant and the challenge it presents to the natural law's claim to normativity. Specifically, this dissertation argues that in Kant's ethics, the normative question is answered in terms of the dignity of humanity, rather than the imago Dei, and that the dignity of humanity is a more relevant, shareable, and normative grounding for ethical reflection. To this end, …

A Higher Law: Transatlantic Revolution And Antislavery Radicalism In Early America, 1760-1800, Anthony Di Lorenzo

Dissertations

During the Age of Revolution, abolitionist ideas interacted with notions of liberty, independence, and equality. Although slavery often served as a metaphor, in opposition to freedom, it also had tangible meanings for the enslaved. This study traces the development of revolutionary beliefs that connected reformers and abolitionists across the Atlantic world, as well as the rise of conservative ideologies that divided them. Democratic politics, religious enthusiasm, and abolitionism converged in the late eighteenth century, with significant implications for antislavery efforts. The French Revolution, in particular, represented the culmination of radical Enlightenment ideals and emboldened democrats in the United States, contributing …

A Fire That Could Not Be Extinguished: Sovereignty And Identity In The Pokagon Band Of Potawatomi Indians, 1634-1994, Melisa Cushing-Davis

Dissertations

American Indian sovereignty and identity, the rights of political and economic self-determination and self-definition, have suffered numerous blows since the time of First Contact. Under the policies of various European nations, and finally the United States, indigenous residents of North America have struggled to maintain political independence, as well as cultural and social integrity, while adapting to changing conditions over which they found themselves, most often, to have little direct control. Such is the history of the Potawatomi people. This dissertation examines the historic responses to these continuing challenges of one band of Potawatomi, the Pokagon of southwestern Michigan. It …