Digital Commons Network^™

Political Essentialism And Affective Polarization, Chase Wilson

Dissertations

Affective polarization, the phenomenon of liberals and conservatives treating each other as disliked outgroups, is increasingly intense (Iyengar & Westwood, 2015; Pew, 2016). In the present research, I used the construct of psychological essentialism (Medin & Ortony, 1989) to help understand this intergroup phenomenon. Specifically, I measured political essentialism, or the belief that political ideologies are strongly determined, informative, discrete and/or immutable, and tested the relationship between these beliefs and affective polarization. I approached this question with both correlational and experimental methods. In a correlational study, political essentialism overall is found to covary positively with affective polarization and social avoidance …

Mechanisms And Consequences Of Epigenetic Inheritance Following Parental Preconception Alcohol Exposure, Annadorothea Asimes

Dissertations

Recent advances in genomics research have revealed that preconception behaviors and experiences of mothers and fathers, including diet, environmental toxicants, and drug abuse, can impact future offspring through epigenetic mechanisms. This means that the risky behaviors of young people, such as the extremely popular practice of binge drinking, have potentially far-reaching consequences for generations to come. While there has been considerable research into fetal alcohol exposure and parental alcoholism, there has yet to be sufficient investigation into the mechanism of epigenetic inheritance or the functional consequences of parental preconception binge pattern alcohol abuse. The hypothesis tested herein is that parental …

Divergent Pro-Leukemic Effects Of Myd88 And Ticam-1/Trif Mediated Toll-Like Receptor Signaling, Joseph Michael Cannova

Dissertations

The goal of this study is to determine the role of Toll-like receptor (TLR) signaling in acute myeloid leukemia (AML). AML is a hematopoietic malignancy that predominately affects the elderly. The median age of AML diagnosis is 67 years old. The standard of care of AML is treatment with cytotoxic chemotherapy, which elderly patients are often unable to tolerate. To identify novel pathways as potential targets for treatment, a microarray on AML primary patient samples was performed to determine the expression of key inflammatory genes. This microarray, and other published datasets, showed that TLR are overexpressed in myelomonocytic (M4) and …

Structural And Chemical Consequences Of High Oxygen Coverages On Rh(111), Rachael Gabrielle Farber

Dissertations

Partial oxidations of small molecules over metal surfaces are central to many heterogeneously catalyzed reactions. However, the identity of the actual surface species that promote or hinder these reactions has remained elusive for a variety of reasons. Recently, the understanding of the role of surface oxides in catalytic activity has changed. Instead of being thought of as poisons, they are now believed to be effective promoters of selective catalysis.

Rhodium (Rh) effectively promotes oxidation reactions and is a benchmark system for models of heterogeneously catalyzed chemistry. For this reason, Rh(111) was chosen as the model system for this dissertation work. …

Role Of Micrornas In Impaired Gut Permeability Following Ethanol And Burn Injury, Niya Latrice Morris

Dissertations

Every year there are nearly 500,000 reported burn injuries in the United States; half of which occur under the influence of alcohol. Clinical studies have shown that burn patients who are intoxicated at the time of injury have a worse prognosis; including increased risk of multiple organ dysfunction syndrome (MODS) and sepsis. The etiology behind these pathological consequences of ethanol and burn injury remains to be elucidated. The Gut-lymph hypothesis of MODS theorizes that trauma (e.g. ethanol and burn injury) results in a redistribution of blood flow to protect more vital organs which leads to ischemia/hypoxia (diminished oxygen delivery) in …

Uncovering The Mechanisms Underlying The Immunogenicity Of Adenovirus Vaccine Vectors, Natalie Nidetz

Dissertations

Vaccination is historically the most effective tool for preventing infectious disease but current vaccine strategies fail to generate robust immunity to major infectious diseases such as HIV and malaria. Therefore, newer vaccine approaches are needed. Vaccines generated from viral, adenovirus based, vectors (AdVs) have proven highly immunogenic in multiple disease models. However, the clinical use of many AdVs is limited by the presence of pre-existing antibodies in human populations, which prevent expression of antigenic genes during immunization with AdVs based on common adenovirus (Ad) serotypes, such as HAdV-5C. Immunization with rare serotype based AdVs, such as HAdV-28D, are not affected …

Nitric Oxide Inhibits Biofilm Formation By Vibrio Fischeri Via The Nitric Oxide Sensor Hnox, Cecilia Thompson

Dissertations

Nitric oxide (NO) is an important signal secreted by the squid, Euprymna scolopes, and is thought to limit symbiotic biofilm formation, the initial step in colonization by the bacterium, Vibrio fischeri. Previous work demonstrated that a mutant defective for NO-sensor HnoX (heme nitric oxide/oxygen binding) had a competitive advantage over wild-type V. fischeri, but the mechanism by which this occurred remains unknown. HnoX is encoded upstream of hahK, a recently identified positive regulator of biofilm formation. I thus hypothesized that HnoX inhibits colonization by controlling HahK-induced biofilm formation during the initiation of colonization.

I assessed the impact of an hnoX …

The Molecular Pathophysiology Of Sepsis-Associated Disseminated Intravascular Coagulation And Its Pharmacologic Modulation, Amanda Temple Walborn

Dissertations

Sepsis is a life-threatening syndrome characterized by a dysregulated host response to infection. Sepsis patients are at risk of disseminated intravascular coagulation (DIC), a severe blood coagulation disorder. In DIC, inappropriate coagulation leads to the deposition of fibrin in the microvasculature and subsequent organ failure. This consumes platelets and coagulation factors, leaving patients at risk of severe or fatal bleeding. No treatments are approved for DIC in the United States.

In order to test the hypothesis that DIC would be best described by a combination of biomarkers representative of multiple physiological processes, an array of biomarkers, representative of hemostasis, inflammation, …

Ecospatial Orientation And American Literature, Lowell Wyse

Dissertations

Place is complex, and it undergirds and influences our fictional and nonfictional narratives in ways we often fail to recognize. In this dissertation, Lowell Wyse argues for a more holistic understanding of place's role in literature while asking what it means to read environmentally€”spatially, ecologically, and historically. Drawing from ecocriticism, which emphasizes the biological world, and geocriticism, which privileges the spatial, Wyse proposes a hybrid "ecospatial" criticism, with a particular emphasis on the role of maps in reading for place. With individual chapters on the nonfiction of William Least Heat-Moon, John Steinbeck's Salinas Valley fiction, Richard Wright's Native Son, and …

The Roles Of Hpa Axis Activity And Attentional Bias In The Development Of Anxiety Symptoms In Low-Income Mexican-Origin Children, Stephanie Brewer

Dissertations

The overarching goal of this research is to increase understanding of the development of anxiety in children of low-income Mexican-origin immigrants. Mexican-origin children display disproportionately high rates of mental disorders such as anxiety, as they face many chronic stressors related to poverty and immigration. A likely mediator of this process is HPA axis activity, causing a buildup of cortisol in the body in response to chronic stress. There is a large amount of evidence indicating that HPA axis activity is a mechanism through which accumulated poverty-related stress causes mental illness, but this mediator has not been examined in relation to …

Shaping Black Boys: Exploring School Construction Of Masculinity And The Impact On Black Male Scholastic Perceptions Toward Academic Achievement And Schooling, Kisha V. Jenkins

Dissertations

African American boys face unique challenges. They are more likely to be suspended or expelled from school than any other racial group (Losen, 2015). Equally disturbing, African American male students are largely suspended for more subjective and ambiguous reasons such as appearing “threatening or disrespectful” (Verdugo, 2007, p. 60). Research on teacher bias in the classroom has indicated that “African American males are generally viewed as possessing characteristics incongruent with academic success (e.g., laziness), valuing athletics over academic accomplishments, and having a propensity toward aggression and violence” (Thomas & Stevenson, 2009, p. 162). These issues experienced by African American males …

A Theory Base And Mission-Sending Model For The South American Division Of The Seventh-Day Adventist Church, Silvano Barbosa

Dissertations

Problem

Effective missionary work depends on a combination of three preconditions, equally indispensable: (1) a body of committed and adaptable personnel who are prepared to transmit to another cultural group the relevance of the Christian message; (2) an organization that is equipped to recruit, train, fund, send, and care for such a missionary force; and (3) sustained access to international unreached areas. Throughout its history, the missionary movement has been based on these three factors and the absence of one or more of them has resulted in less than optimum achievement and has sometimes led to failure. In 2014 the …

Examining The Role Of Arts Education Partnerships In Sustaining Arts Programs In California Elementary Schools, Marie-Helene Bauguil

Dissertations

This study investigated three arts education partnerships in California elementary schools. The research questions that guided the inquiry were exploratory in nature and intended to reveal the day-to-day functioning of these partnerships, the challenges they faced, and the factors that contributed to their success, through the recounted experiences of the various institutional actors involved. The participants (n=21) comprised school principals and teachers, arts organizations administrative staff, and teaching artists. Qualitative inquiry methods (in-person interviews, classroom observations, and review of relevant documents) were used to analyze the data. The findings showed that the schools’ administrators and faculty appreciated the arts residencies, …

Effects Of Trophic Relationships On Oyster Reef Restoration Success In The Mississippi Sound, Virginia Robin Fleer

Dissertations

Natural and anthropogenic changes resulting from altered hydrology, hurricanes, variable precipitation, and the BP oil spill have all taken their toll on oyster reefs in Mississippi. In response, oyster reef restoration efforts are currently underway within the Northern Gulf of Mexico. In order to understand why these efforts succeed or fail, it is crucial to consider predator-prey relationships within the context of the trophic dynamics of oyster reefs. Thus, for this dissertation study I integrated a multidisciplinary approach to understanding key trophic interactions affecting oyster recruitment, growth and survival, comprising field sampling, manipulative lab experiments, and individual-based modeling. Spat settlement …

Examining The Perceived Influence Of A Comprehensive Youth Development Program For Promoting Black Male High School Persistence, Richard Gray Walker

Dissertations

Black male youth in the United States drop out of high school at a rate consistently higher than their White counterparts. A lack of academic persistence contributes to lower workforce participation rates among Black Americans, which leads to lower national productivity and unrealized personal prosperity. Youth development research has developed an extensive body of knowledge regarding possible causes and contributing factors of minority high school dropout. Literature shows youth experience higher dropout rates when they grow up in adversity. Adversity risks such as dysfunctional families, cultural discontinuity between home and school, dysfunctional neighborhoods, or low-expectations from teachers contribute to graduation …

Interindividual Neuromuscular Characteristics And Their Relationships To Running Economy, Barbara Jean Schornstein

Dissertations

Running economy (RE) has previously been shown to be associated with endurance running performance. Neuromuscular characteristics, such as the activity of lower-extremity biarticular muscles during stance, have shown both positive and negative relationships with RE. That is, a positive relationship would indicate as there is more muscular excitation, more oxygen would be used for running, leading to a performance detriment. These conflicting relationships with neuromuscular activity have used two separate electromyographic (EMG) analyses, as there is no gold standard for the processing of EMG data. The first study was performed in order to compare the EMG analysis methods of each …

High Performance Computing Techniques For Analyzing Risky Decision Making, Vinay B. Gavirangaswamy

Dissertations

The process or activity of making choices when subject to gain or loss can be understood as risky decision making (RDM). Risky Decisions consists of outcomes of decisions that may probabilistically result in unfavorable results. Every organism that lives faces this challenge and recent research suggests that there is a computational process involved in making these decisions. This has led to new approaches in the study of RDM. My dissertation is towards contributing to expand on the existing knowledge of RDM processes.

The core contribution of my work is an analysis and development of high performance computing techniques that improves …

A Deep Learníng-Based Data Minimization Algorithm For Big Genomics Data In Support Of Lot And Secure Smart Health Services, Mohammed Aledhari

Dissertations

In the age of Big Genomics Data, institutes such as the National Human Genome Research Institute (NHGRI),1000-Genomes project, and the international cancer sequencing consortium are faced with the challenge of sharing large volumes of data between internationallydispersed sample collectors, data analyzers, and researchers, a process that up until now has been plagued by unreliable transfers and slow connection speeds. These occur due to the inherent throughput bottlenecks of traditional transfer technologies. One suggested solution is using the cloud as an infrastructure to solve the store and analysis challenges. However, the transfer and share of the genomics datasets between biological laboratories …

Ldentifying And Characterizing Cognitive Factors Significant To Practicing And Learning Meteorology, Peggy M. Mcneal

Dissertations

To see the world as a meteorologist, one must understand and interpret atmospheric processes through representations depicted on two-dimensional weather charts and maps that encode large amounts of spatial and numerical data. This is a cognitively demanding and spatially challenging task, especially for students with burgeoning levels of meteorology knowledge, who lack the expertise of practiced meteorologists that read such charts and maps with ease. With little prior work informing meteorology and meteorology education through a cognitive science lens, this study surveys the literature and follows models of discipline-based education and cognitive science research to identify the discrete intelligence factors …

Ecological And Oceanographic Influences On Leatherback Turtle Behavior And Scyphozoan Jellyfish Distributions In The Gulf Of Mexico, Katrina Aleksa

Dissertations

Leatherback turtles (Dermochelys coriacea) are a wide-ranging, oceanic species that feed exclusively on gelatinous zooplankton. Leatherback have been spotted in the Gulf of Mexico (GoM) for several decades and consistently had a high level of interactions with longline fisheries. However, no quantitative studies have been performed to address the spatiotemporal distribution of these turtles in the GoM. This research determines 1) leatherback movements and high-use areas in the GoM, 2) their association with oceanographic features, 3) the distribution and density of two abundant medusae in the northern GoM and any association with biophysical parameters, and 4) the body …

The Effects Of Dopamine On Frequency Dependent Short Term Synaptic Plasticity: A Comparison Of Layer Contributions And Rhythmic Dynamics, Jonna Marie Jackson

Dissertations

Executive functions (e.g. working memory [WM]) are known to be mediated by prefrontal cortical areas of the human brain which share homology with mouse medial prefrontal cortex (mPFC). Furthermore, it is well established that optimal dopaminergic input is required for proper WM function in the PFC. While it is well established that the mPFC receives inputs from several different brain areas, impinging on different compartmental regions of cells, it remains unknown how layer V pyramidal cells, the major output cells of the mPFC, integrate this information. Additionally, it remains unknown how dopamine modulates this integration by way of separate afferents …

Villa-Lobos's Compositional Techniques And Treatment Of Folk Melodies In Cirandas For Piano, Gustavo Schafaschek

Dissertations

Despite his significance as the most important Latin American composer of the twentieth century, serious analytical studies on the music of the Brazilian composer Heitor Villa-Lobos are still few and far between. Recent scholarship has started to demystify the figure of Villa-Lobos as an intuitive composer with no technique, revealing an artist that strove to develop an idiosyncratic musical language. The present document aims to contribute to this new trend in Villa-Lobos’s scholarship by analyzing pieces from the piano cycle Cirandas, W220, considered one of the most important works from the composer’s mature style. Each of the sixteen pieces …

Development, Evaluation, And Application Of A Novel Error Correction Method For Next Generation Sequencing Data, Isaac Akogwu

Dissertations

Tremendous evolvement in sequencing technologies and the vast availability of data due to decreasing cost of Next-Generation-Sequencing (NGS) has availed scientists the opportunity to address a wide variety of evolutionary and biological issues. NGS uses massively parallel technology to accelerate the process at the expense of accuracy and read length in comparison to earlier Sanger methods. Therefore, computational limitations exist in how much analysis and information can be gleaned from the data without performing some form of error correction.

Error correction process is laborious and consumes a lot of computational resources. Despite the existence of many NGS data error correction …

Signature Whistle Production During A Bottlenose Dolphin Group Integration, Megan S. Broadway

Dissertations

Bottlenose dolphins are an important species of interest because they possess a variety of abilities that are relatively rare in the animal kingdom, one being complex acoustic communication. Signature whistles - distinctive calls that are unique for each individual – are one of the most studied call types, but we know little about how these calls are used in various contexts, such as during an introduction. Looking at the socio-behavioral context in which signature whistles are used is likely the best way of learning how these whistles are used in a particular context (Caldwell, Caldwell, & Tyack, 1990). For this …

Cetacean Exhalation: An Examination Of Bottlenose Dolphin (Tursiops Truncatus) Use Of Three Bubble Production Types Through Associated Behaviors, Kelsey Moreno

Dissertations

Bubble production through exhalation is unique to marine mammals due to the combination of their air-breathing physiology and aquatic environment. Multiple types of bubble production are reported in the literature, including bubble netting, trails, bursts, and rings. Unfortunately, apart from bubbles produced to facilitate hunting or play, current understanding of the function of bubble production in cetaceans is limited to anecdotal accounts and author interpretations. This study aims to identify the function of three bubble types though observations of behaviors present before, during, and after bubble production. Instances of bubble trails, bubble bursts, and scant bubbles were selected from underwater …

Escorting Of Mother-Calf Pairs Of Humpback Whales (Megaptera Novaeangliae) In The Colombian Pacific During The Breeding Season, Natalia Botero Acosta

Dissertations

Humpback whales (Megaptera novaeangliae) belonging to the “breeding G-stock” annually migrate from the Antarctic Peninsula and southern Chile to the southeastern Pacific to reproduce. Associations between mother-calf pairs and escorts were examined in the Gulf of Tribugá, northern Colombian Pacific, using photo-identification and behavioral/spatial sampling. Research hypotheses included: 1. The association between cows and escorts is short-lived, consistent with a male reproductive strategy, 2. The presence of escort(s) elicits a behavioral response from mother-calf pairs and, 3. The patterns of spatial distribution reflect the spatial segregation of maternal females. Groups were classified as mother-calf pairs (Mc), mother, calf …

Evaluating Social Network Dynamics Of Bigg’S Killer Whales (Orcinus Orca) And Vessel Traffic Within A Transboundary Region: Implications For Conservation Management, Courtney Smith

Dissertations

The social lives of animals are defined by group dynamics based on the nature and strength of associations and movements between individuals, often resulting in highly complex and interconnected social networks. However, understanding of how environmental variables may shape this structure is poorly understood. Within the inland waters of Washington State and southern Vancouver Island, British Columbia, mammal-eating Bigg’s (transient) killer whales occur in relatively small, but stable social groups. Group size and occurrence in recent years has increased, coinciding with a growing whale watching industry. Given the central importance of the social network within killer whale population dynamics, such …

Transformative Experiential Impacts On Students: An Intervention, Stacy R. Bailey

Dissertations

Students’ successes in first-year writing courses at the university level are critical to academic success and degree completion. Fostering students' engagement in first-year writing courses has proved challenging for institutions of higher education (IHE). Utility value interventions (UV) employing social psychological intervention (SPI) methods have been implemented successfully to aid students in understanding the value of course content and improve achievement. Utility value is the perceived usefulness of a task or content. Similarly, transformative experience (TE) interventions have been implemented with success. Transformative experience is a learning outcome achieved when students re-conceptualize their out-of-school experiences as a result of their …

Technological Pedagogical Content Knowledge (Tpack) Effectiveness On English Teachers And Students In Saudi Arabia, Hamzah Hassan Alhababi

Dissertations

The purpose of this study was to integrate technology into technology-rich, English language learning classrooms in Saudi Arabia. Technological, pedagogical, and content knowledge (TPACK) framework was used to design activities of technology integration for teachers’ and students’ achievement and effectiveness. This study used a mixed-method of quantitative and qualitative to collect data. All participants were male teachers who taught English language courses in public Saudi Arabian schools. Participants were gender specific because the school system in Saudi Arabia separates males and females. The researcher, who was also male, had access to the male portion of the education system and, thus, …

Music To Our Eyes: Assessing The Role Of Experience For Multisensory Integration In Music Perception, Robert Edward Graham

Dissertations

Based on research on the “McGurk Effect” (McGurk & McDonald, 1976) in speech perception, some researchers (e.g. Liberman & Mattingly, 1985) have argued that humans uniquely interpret auditory and visual (motor) speech signals as a single intended audiovisual articulatory gesture, and that such multisensory integration is innate and specific to language. Our goal for the present study was to determine if a McGurk-like Effect holds true for music perception as well, as a domain for which innateness and experience can be disentangled more easily than in language. We sought to investigate the effects of visual musical information on auditory music …