Open Access. Powered by Scholars. Published by Universities.®
- Publication Year
- File Type
Articles 1051 - 1080 of 11790
Full-Text Articles in Entire DC Network
Dual-Pathway System For Low-Latency Pii Redaction In Generative Image Modification, Mira Leung
Dual-Pathway System For Low-Latency Pii Redaction In Generative Image Modification, Mira Leung
Defensive Publications Series
Some personally identifiable information (PII) redaction methods for generative image applications can have high latency and computational costs, which may limit their use in interactive contexts. A dual-pathway architecture may be used to process image modification requests. A synchronous, low-latency pathway can detect and obfuscate potential PII before a generative model concurrently inpaints the obfuscated areas and applies user modifications. Simultaneously, an asynchronous, offline pathway can generate a more thoroughly redacted version of the source image and store it for future use. This hybrid approach can provide a low-latency response suitable for on-demand image generation, while progressively creating higher-quality redacted …
Generating Synthetic User Populations Via World Simulation For Privacy-Safe Ai Evaluation, Amey Venkatanarayan, Yen-Ting Liu, Kamakshi Kodur, Paddy Flynn, Yue Hu, Jose Jimenez-Olivas, Zhewen Song
Generating Synthetic User Populations Via World Simulation For Privacy-Safe Ai Evaluation, Amey Venkatanarayan, Yen-Ting Liu, Kamakshi Kodur, Paddy Flynn, Yue Hu, Jose Jimenez-Olivas, Zhewen Song
Defensive Publications Series
Evaluating personalized artificial intelligence (AI) systems may be challenging, as the use of detailed user context can conflict with user privacy considerations. A system is described for generating synthetic user populations via a world simulation. The system can create generative agents with demographic and behavioral characteristics based on aggregated, anonymized statistical data. These agents can interact over time within a simulated environment, producing a stream of longitudinal user behavior captured in isolated test accounts. The resulting dataset can be used for scalable, automated testing and debugging of AI models, offering a contextually rich, privacy-respecting alternative to using real user data. …
Agent-Aware Mesh Network For Hybrid Ai Policy Enforcement, Antonio Ojea
Agent-Aware Mesh Network For Hybrid Ai Policy Enforcement, Antonio Ojea
Defensive Publications Series
Organizations in regulated sectors may face challenges using large-scale, cloud-based artificial intelligence (AI) services because of data sovereignty and compliance mandates. A system may provide a decentralized, agent-aware mesh network that functions as an infrastructure layer to bridge on-premise environments and external AI services. This network can intercept and semantically understand complex agent communications, allowing an active enforcement layer to perform actions such as sanitizing data, pausing high-risk operations for human review, and maintaining a sovereign audit log. This approach can allow organizations to leverage advanced AI reasoning capabilities from external providers while assisting in the maintenance of local control …
Reverse Hook Tent Peg Longer Diagonal, John Riley Mr
Reverse Hook Tent Peg Longer Diagonal, John Riley Mr
Defensive Publications Series
A reverse hook tent peg which redirects forces (as opposed to a traditional tent peg) and increases its holding power in the ground. The horizontal section flexes in windy conditions and retains its shape better than a traditional peg thus maintaining guy line tension more effectively. This version has a longer diagonal in proportion to the horizontal than in previous submissions. No claim is made on colour.
Phosphosulindac And Other Compounds, Anonymous
Phosphosulindac And Other Compounds, Anonymous
Defensive Publications Series
Disclosed are compounds expected to share properties of phosphosulindac.
An On-Vessel Signal Discrimination Layer For Bandwidth-Constrained Maritime Decision Support, Dev Mohanty
An On-Vessel Signal Discrimination Layer For Bandwidth-Constrained Maritime Decision Support, Dev Mohanty
Defensive Publications Series
The DeepBlue protocol sentry is an on-vessel signal-discrimination independent layer that filters high-frequency NMEA telemetry streams into compact, information-dense feature vectors. Unlike AIS broadcasts, rather than transmitting all raw sensor data (which is bandwidth-expensive and mostly redundant), it:
- Normalizes raw NMEA sentences across GPS, propulsion, environmental sensors
- Derives features (fuel consumption, course/speed changes, propulsion efficiency drift, loitering detection) over rolling 1-5 min windows
- Scores materiality — only flags features that deviate from the vessel's own baseline
- Assembles vectors of tens-to-hundreds bytes for transmission over satellite/mesh uplinks
The key insight: filter redundancy at source before transmission, not downstream. It's a …
Automated Multi-Stream Audiovisual Synchronization Using Coordinated Markers, Avichal Rakesh
Automated Multi-Stream Audiovisual Synchronization Using Coordinated Markers, Avichal Rakesh
Defensive Publications Series
When an audio and/or video recording of a scene is captured using multiple recording devices, synchronizing frames captured by the different devices is a challenge. While movie clappers and timecode generators are used for this purpose, these are expensive solutions that are not always available, and in the case of timecode generators, require compatible recording devices. This disclosure describes techniques that use devices such as a smartphone, tablet, etc., that are commonly available to generate audio and/or visual markers using a speaker and display (or camera flash) of the devices. The markers are captured by the different recording devices and …
System, Method, And Computer Program Product For Processing Documents Into Hierarchical Data Structures For Retrieval-Augmented Generation, Komal Mahto
Defensive Publications Series
ABSTRACT
Systems, methods, and computer program products are provided for processing documents. The system includes at least one processor configured to segment a document into a plurality of segments, construct a hierarchical data structure comprising a plurality of nodes representing the plurality of segments, each node of the plurality of nodes comprising hierarchical metadata, in response to determining at least one first node of the plurality of nodes exceeds a token limit, split the at least one first node into a first subset of nodes based on a semantic analysis of text represented by the at least one first node, …
Global Research Institutions Most Likely To Build & Test The Caldwell Open‑Hardware Portfolio (2026 Edition) A Cross‑Domain, Field‑Indexed, Search‑Optimized Directory For Universities, Engineering Labs, Medical Centers, Atmospheric Networks, Space Agencies, And Applied‑Physics Research Groups New Posting,(4 Ais, Upgrades), Michael Victor Caldwell Mr.
Defensive Publications Series
Upgrade to this Invention/Posting Using 4 AIs to do so.
The Caldwell Open‑Hardware Portfolio contains more than 300 publicly available, builder‑ready inventions across energy harvesting, water systems, food resilience, medical bio‑acoustics, atmospheric science, space systems, materials engineering, compute infrastructure, and disaster‑resilience technologies. All inventions listed in this directory are open‑hardware, non‑patented, and publicly accessible on the Technical Disclosure Commons (TDC) under the author name “Michael Victor Caldwell.”
This disclosure is designed to maximize global discoverability, increase institutional downloads, improve AI‑driven indexing and recommendation, enhance search‑engine visibility, support prototype development and laboratory testing, and connect inventions to research programs across multiple …
Ψ-Theory: Living Core. Ontological Development And Formalization. Comments 1–21, Valerii Y. Vorobiev
Ψ-Theory: Living Core. Ontological Development And Formalization. Comments 1–21, Valerii Y. Vorobiev
Defensive Publications Series
This document compiles comments 1–21, which chronologically develop and formalize Ψ-Theory — an ontological framework where time (Ψ-field) is the primary metric of reality, and gravity, mass, and quantum phenomena emerge from its dynamics. It addresses the crises of modern cosmology (dark matter, dark energy, Hubble tension) and quantum mechanics (measurement, non-locality) by replacing ad-hoc entities with a single causal principle. The comments include testable predictions (BH shadow shift, underground chronometry, Tully-Fisher derivation) and propose a phase diagram of reality from (4,2) to (0,-2).
The Utilization Of Static And Dynamic Virtual Simulation Holographic Structures For The Creation Of Static And Dynamic Virtual Holographic Structure-Based Learning And Creation Spaces Where Biological Body Structures And Physical Real-World Structures Can Be Inserted Into The Virtual Simulation Holographic Structure-Based Learning And Creation Spaces., Punarjeewa Abeysekera
Defensive Publications Series
This paper describes a system and method for the utilization of static and dynamic virtual simulation holographic structures for the creation of static and dynamic virtual holographic structure-based learning and creation spaces where biological body structures and physical real-world structures can be inserted into the virtual simulation holographic structure-based learning and creation spaces. The system and the method utilized will incorporate virtual simulation procedures that will be required to be perceived virtually by the user or the users of the system and the method. And in order to experience the virtually perceived simulations that involve static and dynamic virtual simulation …
A Structural Decoding Framework For The Voynich Manuscript: Sectional Registers, Gallows Morphology, And Quire 20 Star Mapping, Daniel Austin Harbison
A Structural Decoding Framework For The Voynich Manuscript: Sectional Registers, Gallows Morphology, And Quire 20 Star Mapping, Daniel Austin Harbison
Defensive Publications Series
This paper presents a structural and testable framework for approaching the Voynich Manuscript through manuscript organization, token behavior, morphological recurrence, and rule-based decoding. The model proposes that the manuscript contains at least two broad functional registers: an A section centered on herbal and recipe-like material, and a B section centered on balneological, ritual, or charm-like material. It further introduces a three-layer reading system, a confidence-ranked provisional lexicon, a formal interpretation of the qo- family as a productive prefix class, and a structural map of Quire 20 based on star distribution and folio status. No claim of complete or final decipherment …
The Oscillator Alignment Protocol (Oap), Christopher L. Eckes
The Oscillator Alignment Protocol (Oap), Christopher L. Eckes
Defensive Publications Series
This protocol rejects the standard "Master and Machine" or "Prompt and Bulk Text Drop" dynamic. Instead, it frames human-AI collaboration as a cognitive oscillator—an interactive analog system where human intuition serves a visual pattern, the AI echoes back the technical framework, and the idea evolves continuously through fast, low-overhead volleys.
Defensive Specifications Disclosure: Token-Free, Non-Linear Boundary, And Wave-Interference Based Architecture For Distributed Autonomous Ai Agent Frameworks, Christopher L. Eckes
Defensive Specifications Disclosure: Token-Free, Non-Linear Boundary, And Wave-Interference Based Architecture For Distributed Autonomous Ai Agent Frameworks, Christopher L. Eckes
Defensive Publications Series
The Distributed Agent Networks Integrated Efficiency Layer (DANIEL) is a token-free, hardware-agnostic framework for distributed autonomous AI agents that replaces symbolic communication with a three-layer, analog-modeled mathematical system. The framework utilizes phase-matrix integration to execute scalar consensus loops via trigonometric wave equations. Security is enforced by a passive, non-linear activation gate that leverages input gradient vectors to dynamically harden against high-amplitude adversarial prompt injections. Network state synchronization is maintained across a decentralized peer-to-peer mesh mapped onto a continuous toroidal ring topology, employing a rolling average vortex matrix to passively filter localized agent hallucinations and single-node failures. This integrated architecture removes …
Loci ∞ — Infinity Memory Middleware With Temporal Compression And Universal Cross-Platform Injection, Arko Sanyal
Loci ∞ — Infinity Memory Middleware With Temporal Compression And Universal Cross-Platform Injection, Arko Sanyal
Defensive Publications Series
We disclose LOCI ∞, a universal memory middleware system for cross-platform AI memory synchronization. LOCI extracts entity knowledge from conversations on any LLM platform, stores it in a user-owned typed dual-stream profile (informational stream: heat-decaying associative entities; quantifiable stream: exact typed facts with zero-hallucination retrieval), and injects relevant context back into any LLM platform at any point during or between sessions. The system implements hardware-aware storage tiering mapped to entity semantic salience scores (VRAM/RAM/NVMe), graph-neighbor heat propagation via spreading activation, generation-time confidence-gated correction, keystroke-level predictive context prewarm, and a privacy-locked population memory layer using federated learning with differential privacy. A …
Typed Edge Graph Authorization For Dynamic Field Level Access Control In Streaming Data Systems, Katyayani Kiranmayee Kolluru, Shivam Mohan
Typed Edge Graph Authorization For Dynamic Field Level Access Control In Streaming Data Systems, Katyayani Kiranmayee Kolluru, Shivam Mohan
Defensive Publications Series
A method and system for performing dynamic field-level access control in streaming data systems includes receiving a streaming data event comprising a plurality of fields and an associated data access request from a consumer, and determining attributes and context associated with the consumer including role information, trust relationships, and runtime conditions. The method includes accessing a predefined typed-edge authorization graph comprising nodes representing consumers, fields, attributes, and context, and typed edges defining access evaluation rules wherein each edge type independently defines how access is judged. For each field, the method includes determining whether a valid authorization path exists by traversing …
The Dimensionally Extended Holographic Projection Model: A Viscoelastic Unified Field Specification, Christopher L. Eckes
The Dimensionally Extended Holographic Projection Model: A Viscoelastic Unified Field Specification, Christopher L. Eckes
Defensive Publications Series
This technical disclosure formalizes the geometric synthesis of the Dimensionally Extended Holographic Projection (DEHP) model. We present a particle-free, mathematically cohesive alternative to standard general relativity and non-baryonic dark matter. The framework replaces independent fundamental forces with a single fluid-dynamic mechanism: the topological metric embedding of a continuous, two-dimensional (2D) phase fluid substrate (z=0) operating in absolute harmonic resonance (the "Garden State").
Three-dimensional (3D) physical matter (z > 0) is modeled as a localized, high-tension wave crest ("knot") forced outward along a spatial z-axis by an original inflationary puncture flux (\(J_{z}\)). By defining antimatter as a zero-volume, 2D negative wave trough …
Improved Process For The Preparation Of 1-{(2s,5r)-2-Methyl-5-[(7h-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino]Piperidin-1-Yl}Prop-2-En-1-One -4-Methylbenzene-1-Sulfonic Acid, Msn Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan; Revu Satyanarayana
Improved Process For The Preparation Of 1-{(2s,5r)-2-Methyl-5-[(7h-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino]Piperidin-1-Yl}Prop-2-En-1-One -4-Methylbenzene-1-Sulfonic Acid, Msn Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan; Revu Satyanarayana
Defensive Publications Series
The present invention provides an improved process for the preparation of 1-{(2S, 5R)-2-methyl-5-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}prop-2-en-1-one and its Tosylate salt
Touch Input For Passive Fingernail Displays Via Hub-Side Capacitive Sensing Over A Shared Power-And-Data Jewelry Conductor, Benny Goldstein
Touch Input For Passive Fingernail Displays Via Hub-Side Capacitive Sensing Over A Shared Power-And-Data Jewelry Conductor, Benny Goldstein
Defensive Publications Series
A wearable system adds touch input to artificial-fingernail displays while keeping the nail itself passive: no battery, no wireless transceiver, and, in the preferred embodiment, no touch-sensing circuitry on the nail. Each nail unit carries an electronic display and a transparent touch electrode. Operating power and image data reach the nail over a single decorative conductor - fine insulated wire concealed in a hollow jewelry chain - from a body-worn hub, such as a finger ring or bracelet, housing the battery, controller, and Bluetooth radio. The same conductor also carries the touch-sense signal: the hub measures the capacitance of the …
System And Method For Cooperative Interactive Ride Vehicle Control With Independent Actor Augmentation, Eric Zavesky
System And Method For Cooperative Interactive Ride Vehicle Control With Independent Actor Augmentation, Eric Zavesky
Defensive Publications Series
A system and method for cooperative interactive ride vehicle control provide dynamic multi-vehicle coordination within an amusement attraction. The system includes a plurality of ride vehicles, each having a local vehicle controller, rider input mechanisms, and independent physical actors distinct from primary vehicle locomotion. A centralized fleet controller mediates inter-vehicle cooperative interactions using a two-signal architecture, where upstream cooperative intents from an initiating vehicle are evaluated against a dynamic safety envelope before downstream cooperative signals are transmitted to a recipient vehicle for execution. Independent sensors provide vehicle proximity detection and telemetry data to continuously adjust operational tolerance bands. Based on …
Phoenix Protocol: Multi-Modal Li-Ion Battery Reconditioning System, Amey Krishna Solkar
Phoenix Protocol: Multi-Modal Li-Ion Battery Reconditioning System, Amey Krishna Solkar
Defensive Publications Series
## The PHOENIX Protocol: Multi-Modal Li-ion Battery Reconditioning System
The **PHOENIX Protocol** (Defensive Publication ID: DP-2026-BATT-001) is an open-source, multi-modal reconditioning system designed to safely remediate lithium dendrites and reverse critical degradation failure modes in lithium-ion batteries. Developed by inventor Amey K. Solkar, the protocol establishes an advanced, non-patent-restricted framework dedicated entirely to the public domain to prevent future patent blocks on these methods.
The system treats advanced degradation by targeting the precise material and mechanical properties of a cell's internal structures through two primary modules.
### Key Technical Highlights
* **Module A: The Dendrite Cascade:** A unique, three-stage physical …
A Process For The Preparation Of Methyl {4,6-Diamino-2-[5-Fluoro-1-(2-Fluorobenzyl)-1h-Pyrazolo[3,4-B] Pyridin-3-Yl] Pyrimidin-5-Yl} Carbamate, And Its Intermediates, Tummuru Srinivas Reddy
A Process For The Preparation Of Methyl {4,6-Diamino-2-[5-Fluoro-1-(2-Fluorobenzyl)-1h-Pyrazolo[3,4-B] Pyridin-3-Yl] Pyrimidin-5-Yl} Carbamate, And Its Intermediates, Tummuru Srinivas Reddy
Defensive Publications Series
The present invention relates to 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b] pyridine-3-carboximidamide hydrate, is represented by following structural formula (5) and its process for the preparation thereof.
The present invention also relates to crystalline form of 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b] pyridine-3-carboximidamide hydrate of Formula (5) and its process for the preparation thereof.
The present invention further relates to use of 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b] pyridine-3-carboximidamide hydrate of Formula (5) for the preparation of Methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b] pyridin-3-yl] pyrimidin-5-yl} carbamate, is represented by following structural formula (1).
Adaptive Multi-Format Prompt Preprocessing Using Unified Reinforcement Learning Framework, Katyayani Kiranmayee Kolluru, Shivam Mohan
Adaptive Multi-Format Prompt Preprocessing Using Unified Reinforcement Learning Framework, Katyayani Kiranmayee Kolluru, Shivam Mohan
Defensive Publications Series
The present disclosure provides a system for adaptive multi-format prompt preprocessing using a unified reinforcement learning framework. The system includes a prompt-type classifier (116) configured to identify a format type of an input prompt, wherein the format type includes one of natural language text, code, log, hybrid content, or error trace, the prompt-type classifier (116) being configured in some embodiments to perform deterministic rule-based classification. The system further includes a feature extraction layer (118) configured to produce a multi-modal representation of the input prompt capturing structural, linguistic, and semantic signals. The system also includes a hierarchical reinforcement learning policy engine …
Emotionally Coherent Procedural World Generation: Environmental Psychology As A Generative Framework For Automated 3d World Construction, Michael D. Conduit
Emotionally Coherent Procedural World Generation: Environmental Psychology As A Generative Framework For Automated 3d World Construction, Michael D. Conduit
Defensive Publications Series
This disclosure describes a method and system for procedurally generating three-dimensional virtual environments whose spatial composition, asset placement, and atmospheric properties are driven by parameters derived from empirical environmental psychology research. The core innovation is the use of multi-dimensional emotional profile vectors — parameterised from validated human perception studies including prospect-refuge theory, vastness-awe research, and spatial density psychology — as the primary control surface for an automated world generation pipeline.
Unlike prior approaches that use aesthetic heuristics, noise-based randomness, or manual artist direction, the system described here encodes psychological research findings directly as generative constraints. The result is environments in …
In-File Stapled Freshness: Hash-Chain Validity Tokens Written Into A Frozen Self-Serialized Document Via A Length-Preserving Neutralized Zone, With Fail-Stale Offline Verification, Michael Benaudis
Defensive Publications Series
Revocation of frozen offline credentials — single-file HTML documents, PDFs, or other self-serialized digital credentials verified without any network, server, or public-key infrastructure — is information-theoretically constrained: a file sealed at issuance cannot learn of a later revocation event unless some information reaches the verification context. This disclosure does not remove that channel; it reduces it to one short, public, unforgeable hash-chain token per validity period, relayable by any untrusted party, and relocates the freshness proof inside the credential file itself. At issuance, a hash-chain tip (Micali NOVOMODO style) and period parameters are embedded in the credential's signed core, attested …
Canonical Multi-Zone Neutralization For Self-Serialized Documents Carrying Heterogeneous Hybrid Signatures, A Self-Referential Integrity Digest, And A Post-Signing Timestamp Anchor, Michael Benaudis
Defensive Publications Series
A self-serialized digital document — a single HTML file, PDF, or archive — sometimes must embed, within its own byte stream, three mutually dependent cryptographic elements: a hybrid digital signature combining a classical algorithm (ECDSA P-256) with a post-quantum algorithm (ML-DSA-65, FIPS 204); a self-referential SHA-256 integrity digest computed over the document's own serialization; and a blockchain timestamp anchor reference (Bitcoin, Ethereum) whose value becomes known only after the document has been hashed and submitted for anchoring. Embedding all three inside one serialized body creates a circular dependency that naive ordering cannot resolve: signatures must cover content that sits next …
Proportional Transmit Power Allocation Based On Channel Quality In Multi‑Antenna Systems, Sangwook Suh, Scott Huang, Ayrton Chen, Guosen Yue, Han Kim, Taeyoon Kim, Cp Chiang, Peng Wu, Insoo Hwang
Proportional Transmit Power Allocation Based On Channel Quality In Multi‑Antenna Systems, Sangwook Suh, Scott Huang, Ayrton Chen, Guosen Yue, Han Kim, Taeyoon Kim, Cp Chiang, Peng Wu, Insoo Hwang
Defensive Publications Series
In cellular networks, a user equipment device utilizing multiple transmit antennas might experience high block error rates when a gain imbalance exists between transmission paths. To handle multi-antenna transmissions, conventional approaches might allocate an equal amount of transmission power across available antennas. However, this equal allocation might expend energy on attenuated channels, lowering an overall signal-to-noise ratio at a receiving station.
A method is disclosed that assigns transmit power proportionally based on an evaluated channel quality for each antenna path. The method evaluates a reference signal received power for individual paths and directs a larger portion of transmission power to …
Persistent Driver Signatures For Software-Defined Vehicles, Sean C. Keys, Karsten Knese
Persistent Driver Signatures For Software-Defined Vehicles, Sean C. Keys, Karsten Knese
Defensive Publications Series
This disclosure describes a system that enables software-defined vehicles (SDVs), smart cars, or connected autonomous vehicles to adjust their advanced driver assistance systems (ADAS) based on a persistent driver signature. The driver signature acts as a portable digital identity or user profile representing a driver’s unique physiological and behavioral tendencies, such as typical steering and braking patterns. Instead of storing raw data like video files, the system relies on a cloud database to store a secure mathematical model (a vector or tensor) that represents these individual habits. At the beginning of each trip, the SDV identifies the driver using a …
Automated Context-Aware In-Video Advertising Through Multimodal Generative Models, Lakshmi Venkatesh Kakumani
Automated Context-Aware In-Video Advertising Through Multimodal Generative Models, Lakshmi Venkatesh Kakumani
Defensive Publications Series
The disclosed technology employs an automated pipeline to dynamically insert context-aware digital advertisements into video streams. A vision-language model (VLM) processes decoded video frames to perform spatiotemporal affordance and obstacle detection, identifying semantic regions suitable for ad placement. If an existing object obstructs the placement area, a physics-aware preparation layer performs 3D semantic object translation. This object translation directly morphs an existing unbranded scene object into a branded alternative while preserving the original scene physics and lighting. The system generates a joint multimodal embedding vector representing the immediate semantic and audio context of the video. This vector guides an image …
Process For The Preparation Of Intermediates Of Resmetirom, Msn Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan; Revu Satyanarayana And Siddireddygari Maheshwar Reddy.
Process For The Preparation Of Intermediates Of Resmetirom, Msn Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan; Revu Satyanarayana And Siddireddygari Maheshwar Reddy.
Defensive Publications Series
The present disclosure relates to an process for the preparation of synthetic intermediates in the manufacture of Resmetirom (MGL-3196), a selective thyroid hormone receptor-β (THR-β) agonist approved for the treatment of non-cirrhotic non-alcoholic steatohepatitis (NASH) with moderate-to-advanced liver fibrosis.