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Articles 301 - 304 of 304
Full-Text Articles in Entire DC Network
Inhibition Of T Lymphocyte Mitogenesis By 1,25-Dihydroxyvitamin D3 (Calcitriol)., William F.C. Rigby, Terryl Stacy, Michael W. Fanger
Inhibition Of T Lymphocyte Mitogenesis By 1,25-Dihydroxyvitamin D3 (Calcitriol)., William F.C. Rigby, Terryl Stacy, Michael W. Fanger
Dartmouth Scholarship
Recent studies have suggested that vitamin D may have other important biologic activities in addition to its well-characterized role in the maintenance of calcium homeostasis. Discovery of cytosolic receptors for vitamin D in human peripheral blood monocytes and lectin-stimulated lymphocytes prompted us to study the effects of 1,25-dihydroxyvitamin D3 (calcitriol), the most biologically active metabolite of vitamin D, upon phytohemagglutinin (PHA)-induced lymphocyte blast transformation. We have found that calcitriol is a potent inhibitor of PHA-induced lymphocyte proliferation, achieving 70% inhibition of tritiated thymidine incorporation after 72 h in culture. Furthermore, calcitriol suppressed interleukin-2 (IL-2) production by PHA-stimulated peripheral blood mononuclear …
Inhibition Of Growth Of Toxoplasma Gondii In Cultured Fibroblasts By Human Recombinant Gamma Interferon., E. R. Pfefferkorn, Paul M. Guyre
Inhibition Of Growth Of Toxoplasma Gondii In Cultured Fibroblasts By Human Recombinant Gamma Interferon., E. R. Pfefferkorn, Paul M. Guyre
Dartmouth Scholarship
The growth of Toxoplasma gondii in cultured human fibroblasts was inhibited by recombinant human gamma interferon at concentrations of 8 to 16 U/ml. The interferon was titrated by observing a total inhibition of parasite plaque formation 7 days after infection. Inhibition of the growth of T. gondii in the early days after infection was measured by marked reductions in the incorporation of radioactive uracil, a precursor that can only be used by the parasites. This assay showed that when cells were pretreated with gamma interferon for 1 day and then infected, inhibition of T. gondii growth could be readily detected …
Gamma Interferon Induces Monocytoid Differentiation In The Hl-60 Cell Line., Edward D. Ball, Paul M. Guyre, Li Shen, John M. Glynn, Charles R. Maliszewski, Paul E. Baker, Michael W. Fanger
Gamma Interferon Induces Monocytoid Differentiation In The Hl-60 Cell Line., Edward D. Ball, Paul M. Guyre, Li Shen, John M. Glynn, Charles R. Maliszewski, Paul E. Baker, Michael W. Fanger
Dartmouth Scholarship
We investigated the ability of purified, recombinant DNA-derived interferons (IFN) to induce phenotypic changes in cells of the HL-60 promyelocytic leukemia cell line. Changes in cell surface markers detected by monoclonal antibodies as well as morphologic, histochemical, and functional changes were monitored. We found that gamma-IFN, but not alpha- or beta-IFN, induced the expression of antigens characteristic of monocytes and granulocytes (AML-2-23, 63D3, and 61D3), as well as changes in morphology consistent with monocytoid differentiation. These included induction of alpha-naphthyl acetate esterase, increased cell size, and a decrease in azurophilic granules. The gamma-IFN dose dependency and time course of the …
Monoclonal Antibodies To Novel Myeloid Antigens Reveal Human Neutrophil Heterogeneity., Edward D. Ball, Robert F. Graziano, Li Shen, Michael W. Fanger
Monoclonal Antibodies To Novel Myeloid Antigens Reveal Human Neutrophil Heterogeneity., Edward D. Ball, Robert F. Graziano, Li Shen, Michael W. Fanger
Dartmouth Scholarship
Three cytotoxic murine monoclonal antibodies that recognize myeloid-specific antigens have been produced by immunization with normal human neutrophils or myeloblasts from a patient with acute myelomonocytic leukemia. Two of these, PMN 6 and PMN 29, are specific for neutrophils; the third monoclonal antibody, AML-2-23, is reactive with the majority of normal monocytes as well as a subpopulation of mature neutrophils. Although neutrophils from all individuals tested expressed these antigens, cytofluorographic analysis revealed that the percentage of cells bearing the PMN 6 and AML-2-23 antigens varied among individuals. Significant additional heterogeneity in the density of each antigen among antigen-bearing cells was …