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Articles 5221 - 5250 of 6481
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Effects Of 4,5,4'-Trihydroxy-3,3'-Dimethoxybibenzyl From Dendrobium Ellipsophyllum On Induction Of Apoptosis And Inhibition Of Cancer Stem-Like Cells In Human Lung Cancer H460 Cells, Anirut Hlosrichok
Chulalongkorn University Theses and Dissertations (Chula ETD)
Failure of current chemotherapeutic drugs leads to the recurrence of tumors and increased mortality in lung cancer patients. This study investigated 4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl (TDB), a bibenzyl extracted from Dendrobium ellipsophyllum Tang and Wang as a novel anticancer agent for lung cancer. Selective anticancer activity of TDB against human lung cancer cells was demonstrated with a high half maximal inhibitory concentration (IC50) approximately > 300 µM in dermal papilla cells, while IC50 in human lung cancer H460 cells was approximately 100 ± 5.18 µM. Flow cytometry confirmed that TDB (50 µM) treatment for 24 h, caused significant early and late apoptosis but not …
Effect Of Major Triterpenoids Of Centella Asiatica On Neurite Outgrowth In Neuro-2a Cells, Nonthaneth Nalinratana
Effect Of Major Triterpenoids Of Centella Asiatica On Neurite Outgrowth In Neuro-2a Cells, Nonthaneth Nalinratana
Chulalongkorn University Theses and Dissertations (Chula ETD)
Centella asiatica has been reported to demonstrate neuroprotection and memory improvement in various animal models. Triterpenoid glycosides, madecassoside (MS), asiaticoside (AS), and their aglycones, madecassic acid (MA) and asiatic acid (AA) are considered as major neuroactive constituents in C. asiatica. In this study we aimed to compared MS, AS, MA and AA for their neurite outgrowth activities and mechanisms in Neuro-2a cells. Immunofluorescent staining against ßIII-tubulin showed that MS and AS significantly increased the percentage of neurite-bearing cells and neurite length with higher potency than MA and AA. Our mechanistic studies revealed the differences in signal activation between glycosides and …
A Study On The In Vitro Stability And Metabolism Of Curcumin Diethyl Disuccinate In Plasma, Pahweenvaj Ratnatilaka Na Bhuket
A Study On The In Vitro Stability And Metabolism Of Curcumin Diethyl Disuccinate In Plasma, Pahweenvaj Ratnatilaka Na Bhuket
Chulalongkorn University Theses and Dissertations (Chula ETD)
Stability in aqueous media such as buffers and plasma are the one of important properties of drug candidates. Curcumin diethyl disuccinate (CDD), an ester prodrug of curcumin, has been developed to improve the chemical stability of curcumin. In this study, the in vitro stability of CDD in HCl buffer (pH 1.2), acetate buffer (pH 4.5), phosphate buffer (pH 6.8, 7.4 and 8.0) and in vitro metabolism of CDD in rat, dog and human plasma were investigated at 4, 25 and 37 °C. HPLC and nonlinear regression analyses showed that the degradation of CDD in buffers was temperature-dependent and followed pseudo-1st …
Optimization Of Protein Hydrolysate Preparation From Split Gill Mushroom Schizophyllum Commune, Aunchalee Wongaem
Optimization Of Protein Hydrolysate Preparation From Split Gill Mushroom Schizophyllum Commune, Aunchalee Wongaem
Chulalongkorn University Theses and Dissertations (Chula ETD)
The optimum conditions for hydrolysate production from split gill mushroom protein using the microbial protease, Alcalase were investigated. The study was conducted using central composite design and response surface methodology. Three independent factors: hydrolysis temperature (45, 50, and 55 °C); hydrolysis time (60, 120, and 180 min); and enzyme to substrate ratio (2%, 4%, and 6% w/v) were varied, while the pH was fixed at pH 8. These three factors had a significant effect on the DH and ABTS radical-scavenging activity (p < 0.05). The optimum conditions obtained from experiments were: enzyme to substrate ratio 2%; hydrolysis time 161.4 min; and temperature 55 °C. The coefficient of determination (R2) of total protein and the IC50 value for ABTS radical-scavenging activity were 0.972 and 0.205 µg/mL, respectively, and the DH value was 50.882%. The hydrolysate was fractionated by molecular weight (MW) cut-off membranes (10, 5, 3, and 0.65 kDa). The < 0.65 kDa fraction had the highest radical scavenging ability (IC50 = 0.026 ± 0.004 µg/mL). The MW < 0.65 kDa fraction was separated by reversed-phase HPLC to yield four subfractions (F1–5). The F4 subfraction showed the highest maximum ABTS radical-scavenging activity and was selected for further analysis by quadrupole-time-of-flight-electron spin induction–mass spectrometry-based. Five antioxidant peptides were identified. In addition, the MW< 0.65 kDa fraction protected against oxidation-induced DNA damage in pBR322, pKS, and pUC19 plasmids. Furthermore, the MW < 0.65 kDa fraction, exhibited cellular antioxidant activity in a human intestinal cancer cell line (HT-29), which was dependent on the peptide concentration. These results suggested that split gill mushroom protein hydrolysate is a good source of bioactive peptides and has potential as a natural antioxidant in food production and cosmetic products.
Reaction Mechanisms Of Substrate And Inhibitor With Ns2b/Ns3 Serine Protease Of Zika Virus By Mm And Qm/Mm Simulations, Bodee Nutho
Chulalongkorn University Theses and Dissertations (Chula ETD)
Zika virus (ZIKV) infection has become a public health concern worldwide. The recent epidemiological data have revealed a possible association of ZIKV infection with neurological manifestations in both newborn children and adults. Currently, there is no anti-ZIKV drug or vaccine available for preventing or controlling ZIKV infection. An attractive drug target for ZIKV treatment is NS2B/NS3 serine protease that plays a crucial role to cleave the peptide bond during the viral replication process. Initially, the ZIKV NS2B/NS3 serine protease in complex with four peptide substrates were studied to investigate the binding recognition and protein-substrate interactions using conventional molecular dynamics (MD) …
Development And Screening Of Chalcones Against Cancer Protein Targets Using In Silico And In Vitro Techniques, Kanyani Sangpheak
Development And Screening Of Chalcones Against Cancer Protein Targets Using In Silico And In Vitro Techniques, Kanyani Sangpheak
Chulalongkorn University Theses and Dissertations (Chula ETD)
Targeted cancer therapy has become one of high potential cancer treatments. Human topoisomerase IIα (hTopoIIα) and Epidermal growth factor receptor tyrosine kinase (EGFR-TK) are proteins that play important roles on cell cycle. The hTopoIIα catalyzes the cleavage and rejoining of double-stranded DNA while EGFR function on cell signaling. Thus, the two proteins have been suggested as molecular target for the development of novel cancer therapeutics. A series of 47 chalcone derivatives was screened against hTopoIIα and EGFR-TK by in silico and in vitro techniques. Chalcone 3d showed a high cytotoxicity with IC50 values of 10.8, 3.2 and 21.1 µM against …
Extraction Of Spent Green Tea Leaves As Bioactive-Compound Source, Monsichar Yannarat
Extraction Of Spent Green Tea Leaves As Bioactive-Compound Source, Monsichar Yannarat
Chulalongkorn University Theses and Dissertations (Chula ETD)
Spent green tea leaves (SGTL) are a major contributor to the high cost of commercial tea products because of the large amount of leftover and the cost of disposal. This research investigates on the solvent and time for the extraction of SGTL that provides good yield of potential compound and to separate bioactive compounds as enrich-fractions and pure compounds. The obtained fractions were evaluated for antioxidant, antityrosinase, anticholinesterase and plant growth regulator activities. Caffeine was found in all samples. Among five extracts, the dichloromethane extract revealed high caffeine content (92.8 %peak area), while the methanol extract showed the highest five-catechin …
Optimization Of Protein Hydrolysate Preparation And Their Angiotensin I-Converting Enzyme Inhibitory Activity From Shiitake Mushrooms Lentinula Sp., Supawee Paisansak
Optimization Of Protein Hydrolysate Preparation And Their Angiotensin I-Converting Enzyme Inhibitory Activity From Shiitake Mushrooms Lentinula Sp., Supawee Paisansak
Chulalongkorn University Theses and Dissertations (Chula ETD)
Angiotensin-I converting enzyme (ACE) is a key enzyme involved in regulating blood pressure. ACE converts angiotensin-I into angiotensin-II, which results in raised blood pressure. Inhibition of ACE leads to a decreased concentration of angiotensin-II and lowering of blood pressure. Food protein-derived ACE inhibitory peptides are considered to be a safer alternative to antihypertensive drugs. Shiitake mushrooms, one of the most consumed mushrooms in Thailand, are recognized as a nutritive food with health-stimulating properties. The aim of this study was to optimize the preparation of a shiitake-protein hydrolysate and investigate the ACE inhibitory activity of the hydrosylate. Shiitake mushrooms were hydrolyzed …
Glycation And Α-Glucosidase Inhibitors From Boesenbergia Rotunda And Lansium Parasiticum, Thammatee Potipiranun
Glycation And Α-Glucosidase Inhibitors From Boesenbergia Rotunda And Lansium Parasiticum, Thammatee Potipiranun
Chulalongkorn University Theses and Dissertations (Chula ETD)
Glycation is spontaneous non-enzymatic reaction between protein and glycation precursors; methylglyoxal (MG) that initially yields advanced glycation end-products (AGEs), which ultimately trigger to several severe complications. Therefore, the inhibition of AGEs formation is the imperative approach for alleviating diabetic complications. Moreover, one of typical diabetic therapy is α-glucosidase inhibition to reduce glucose level in bloodstream. Therefore, this research aims to study bioactivity and mechanism of natural products to inhibit glycation and α-glucosidase. From preliminary study of some phenolic compounds, flavanones from fingerroot (Boesenbergia rotunda) could inhibit glycation. The dichloromethane extract of fingerroot afforded three flavanones (pinocembrin, pinostrobin, and alpinetin), two …
Reforming Regulation Of Multi-Level Marketing In Myanmar, Zeyar Nyunt Oo
Reforming Regulation Of Multi-Level Marketing In Myanmar, Zeyar Nyunt Oo
Chulalongkorn University Theses and Dissertations (Chula ETD)
The business of multi-level marketing is prohibited in Myanmar under the Notification no 46/2018. There are not only three paragraphs but also lack of the definition of MLM in this Notification. If distributors sell any product through MLM in Myanmar, they will be punished with imprisonment for a term exceeding three years under section 5 of the Myanmar Essential Goods and Services Law 2012. The study of the provisions on the business of MLM in selected ASEAN countries, Indonesia, Malaysia, Thailand, and Singapore indicates that the definition of multi-level marketing and pyramid scheme is not the same. Moreover, businessman and …
Reactive Extraction Of Metal Ion And Simultaneous Stripping Using Nanofibers-Supported Liquid Membrane In A Microchannel, Nattakarn Chucherd
Reactive Extraction Of Metal Ion And Simultaneous Stripping Using Nanofibers-Supported Liquid Membrane In A Microchannel, Nattakarn Chucherd
Chulalongkorn University Theses and Dissertations (Chula ETD)
Heavy metals in wastewater resulting from industries have become a prime concern for both environmental and economic reasons. This work intends to recover ions of heavy metal from wastewater using reactive extraction by nanofibers-supported liquid membrane (NSLM) in a microchannel. The use of supported liquid membrane enables simultaneous extraction and stripping (i.e., recovery of the extractant) processes. In this study, the NSLM was applied in a microchannel to minimize mass transfer resistance, hence improving overall performance of the extraction. Copper (II) ion was used as a model ion, while di-2-ethylhexyl phosphoric acid (D2EHPA) dissolved in kerosene was used as the …
Electrode Improvement Using Diamond-Like Carbon For Electrochemical Advanced Oxidation In Diuron Degradation, Nimit Kantiyawong
Electrode Improvement Using Diamond-Like Carbon For Electrochemical Advanced Oxidation In Diuron Degradation, Nimit Kantiyawong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Diuron is one of the pesticides. Its residual can contaminate natural water resource resulting in environmental and human health problems. Several processes have been used to remove diuron contamination. Nowadays, an electrochemical advanced oxidation process (EAOP) in a microchannel reactor is used to degrade diuron owing to its high efficiency. In this research, the diamond-like carbon (DLC) thin film was used as an electrochemical electrode because it has superior hardness and electrical conductivity. In this research, we have successfully synthesized the DLC thin films using graphite as target material on the surface of 304 stainless steel substrate by the direct …
Computational Fluid Dynamics Modeling Of The Climate Inside A Chicken House, Nuttaphon Kanjanaudomsuk
Computational Fluid Dynamics Modeling Of The Climate Inside A Chicken House, Nuttaphon Kanjanaudomsuk
Chulalongkorn University Theses and Dissertations (Chula ETD)
Nowadays, most of chicken products are from a closed house system. Climate inside such chicken house can significantly affect chicken welfare and its productivity. Moreover, Thailand is in a tropical region where thermal stress is easily occurred. Suitable operating condition and chicken house design can help improve interior climate which can be evaluated by computational fluid dynamics (CFD) modeling technique. In this study, realizable k-ε model, energy conservation and species transport equations were applied to simulate the air velocity, temperature and relative humidity, respectively, inside the chicken house. The model was validated with measured air velocity, temperature and relative humidity …
Development Of Suture Pad From Silk-Reinforced Polydimethylsiloxane Composite, Radhitya Banuaji Prastowo
Development Of Suture Pad From Silk-Reinforced Polydimethylsiloxane Composite, Radhitya Banuaji Prastowo
Chulalongkorn University Theses and Dissertations (Chula ETD)
The aim of this research is to investigate the mechanical properties of polydimethylsiloxane reinforced with short silk fibers for suture pad application. The effect of aspect ratio and fibers content of the polydimethylsiloxane reinforced with silk fibers on the properties was evaluated. From the results, tensile modulus and tensile strength of polydimethylsiloxane reinforced with different aspect ratio were increased with increasing aspect ratio and fibers content. The composite with the addition of silk fiber produces higher tear resistance with suture thread compared with pure polydimethylsiloxane. Furthermore, the hardness of polydimethylsiloxane reinforced with short silk fibers was improved with the addition …
Carbon Sorbent Reinforced Hollow Fiber Membrane Microextraction For Determination Of Trace Polar Organic Compounds, Chanatda Worawit
Carbon Sorbent Reinforced Hollow Fiber Membrane Microextraction For Determination Of Trace Polar Organic Compounds, Chanatda Worawit
Chulalongkorn University Theses and Dissertations (Chula ETD)
This work presents a proof of concept that hollow fiber liquid phase microextraction reinforced with carbon nanomaterials would improve the extraction efficiency of small and relatively polar organic compounds. Several types of carbon sorbents such as graphite, graphene, carbon nanofiber were studied. In research I, the hollow fiber membrane reinforced with graphite was developed for liquid phase microextraction of trihalomethanes in water samples. Parameters affecting extraction efficiency including organic solvent as supported liquid membrane, amount of loaded graphite and extraction time were investigated and optimized. The working range of 0.2-120 µg L-1 was obtained in 10 min extraction with good …
Enzymatic Reaction Based Biosensor For Specific Detection Of Organophosphate Pesticides, Chonticha Sahub
Enzymatic Reaction Based Biosensor For Specific Detection Of Organophosphate Pesticides, Chonticha Sahub
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research aims to design and develop two-biosensor platforms based on graphene quantum dots (GQDs) via enzymatic reaction for determining organophosphate pesticides (OPs). A first platform consisting of GQDs and active enzyme, GQDs/Enz platform, is simply fabricated in aqueous solution. Ongoing development of GQDs/Enz platform for effective OPs sensing by hybrid hydrogel (GQDs/Enz/Gels) was of great interest to improve the sensitivity and enzyme stability under the benefit of easy to be used for sensing approach. The GQDs/Enz and GQDs/Enz/Gels were constructed and characterized by general methods such as FT-IR, SEM and TEM. Based on the concept, H2O2 generated in situ …
Speciation Of Arsenic Using Sulfur Containing Ligand And Cotton Wool By Icp-Oes, Kavee Triteeyaprasert
Speciation Of Arsenic Using Sulfur Containing Ligand And Cotton Wool By Icp-Oes, Kavee Triteeyaprasert
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research aimed to develop a method for speciation of arsenic species including As(III) and As(V) in environmental samples. Cotton wool and sulfur containing ligands including ammonium pyrrolidinedithiocarbarmate (APDC), L–cysteine and diethyldithiocarbamic acid were used in a solid phase extraction and determination of arsenic by using inductively coupled plasma optical emission spectrometry. The separation parameters were studied including pH, ligand concentration, cotton amount, type of eluents and flow rate. It was found that at pH 2, 0.1% APDC concentration and 0.5 g of cotton, As(III) could form complex with APDC (As(III) – APDC) and was separated from As(V) by using …
Fluorescent Sensors From Salicylaldimine Derivatives For Metal Ions, Phoom Sangsuwan
Fluorescent Sensors From Salicylaldimine Derivatives For Metal Ions, Phoom Sangsuwan
Chulalongkorn University Theses and Dissertations (Chula ETD)
An in-situ forming and sensing was developed as a high-throughput screening of fluorescent chemosensors for metal ions. The 45 salicylaldimines, formed in-situ from the condensation between 5 salicylaldehydes and 9 amines, in 96 well-plates were photographed under black light along with the 5 salicylaldehydes in the absence and presence of 18 metal ions. The library of fluorescence response images of these 50 chemosensors were processed into RGB values. The PCA of theΔRGB, the differences between those of images with and without the metal ions, showed 9 sensors with normalized loading value over 70%. The sensor array constructed from these 9 …
Detection Of Sulfonamide Residues By Paper Spray Mass Spectrometry, Surased Suraritdechachai
Detection Of Sulfonamide Residues By Paper Spray Mass Spectrometry, Surased Suraritdechachai
Chulalongkorn University Theses and Dissertations (Chula ETD)
Sulfonamide antibiotics are commonly used veterinary drugs in livestock to prevent or treat infectious diseases. Their residues in food are of concern since they can cause adverse health effects and development of bacterial resistance. In this work, a practical method for detection and quantification of sulfamethazine, one of sulfonamide antibiotics, in pig body fluid samples is developed via the combination of simple extraction and paper spray mass spectrometry. The method required minimal sample preparation and low analysis time while providing high sensitivity and accuracies in pig whole blood (LOD = 10.1 ng/mL, %recovery = 95.4-104.1%), pig serum (LOD = 4.6 …
Synthesis And Antidiabetic Activity Of Furofuran Lignans Containing Multiphenolic Groups, Titiruetai Doungwichitrkul
Synthesis And Antidiabetic Activity Of Furofuran Lignans Containing Multiphenolic Groups, Titiruetai Doungwichitrkul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Synthesis of furofuran lignans containing multiphenolic groups (6-12) was carried out. The starting material samin (5) was obtained by acid hydrolysis of sesamin (2), which was isolated from sesame seed oil. A series of target lignans were synthesized from samin (5) and a varity of phenolics through Friedel-Crafts reaction, yielding desired products (6). To increase number of hydroxy moieties on the synthesized lignans, oxidative reaction using lead (IV) tetraacetate was performed. Removal of methylenedioxy of furofuran lignans containing a phenolic moiety produced unexpected products which contains para-quinone together with ortho-dihydroxy moieties on furofuran core structures (8-9). Consequently, to avoid oxidation …
The Relationship Of Influential Factors On Material Management Effectiveness In Building Construction Projects: Case Study In Vietnam, Bao Van Pham
Chulalongkorn University Theses and Dissertations (Chula ETD)
The improvement of management processes in construction could be seen as one of the important keys to project success in which material management should be appropriately taken into consideration. Although many previous research studies have examined the components of construction material management, the relationship of factors influencing material management effectiveness has not been explored. This study was carried out to identify influential factors on material management effectiveness and develop a model to explain the relationships between these factors and the effectiveness of material management based on practical projects. The research method included the collection of contractors' opinions in building projects …
A Bim-Database-Integrated System For Evaluating Building Life-Cycle Costs Using A Multi-Parametric Model, Hang Thi Thu Le
A Bim-Database-Integrated System For Evaluating Building Life-Cycle Costs Using A Multi-Parametric Model, Hang Thi Thu Le
Chulalongkorn University Theses and Dissertations (Chula ETD)
Life-cycle cost analysis (LCCA) has become an essential requirement of the sustainable procurement for many construction projects. Conventional building LCCA methods are extremely complex and time-consuming due to repetitive works, numerous required data, scattered data inputs, and various regulatory requirements, which subsequently lead to inaccurate building life-cycle costs (LCC). Building information modeling (BIM) offers a revolutionary information technology, which can overcome the asperities of the conventional building LCCA. This research develops the BIM-database-integrated system for evaluating building life-cycle costs using a multi-parametric model (BIM-BLCC). The BIM-BLCC consists of four interrelated modules. The relational database management module collects and organizes the …
The Effect Of Nac And Carnosine On AlzheimerS Disease-Related In Vitro Model Through Rage-Age Signaling Pathway, Suphasarang Sirirattanakul
The Effect Of Nac And Carnosine On AlzheimerS Disease-Related In Vitro Model Through Rage-Age Signaling Pathway, Suphasarang Sirirattanakul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Alzheimer’s disease (AD) is the most common dementia which found increasing with age. It involves neurodegeneration which leads to various abnormalities especially memory loss, inability to learn new things, lack of creativity, lack of decision making ability, lack of critical thinking, calculation inability, inability to live normal daily life, inability to recognize person, time and place, emotional disturbance, and difficulty to use language. Since AD has severe impact in various aspects on both the patients and their families, so we are interested to study the neurodegenerative mechanism when neuronal cells are under oxidative stress which will induce neuroinflammation through the …
Effect Of Ercc1, Xrcc1 And Gstp1 Polymorphisms On Clinical Response And Adverse Events Of Platinum-Based Chemotherapy In Epithelial Ovarian Cancer Patients, Salisa Liblab
Chulalongkorn University Theses and Dissertations (Chula ETD)
Platinum-based chemotherapy is the first line chemotherapy regimen for epithelial ovarian cancer (EOC). Pharmacogenomics is one factor that might affect its efficacy and toxicity. This cohort study was aimed to investigate the association between ERCC1, XRCC1 and GSTP1 polymorphisms on clinical responses and adverse events related to platinum-based chemotherapy in Thai EOC patients. Fifty-two patients with advanced EOC were enrolled in this cohort study. The mean age was 55.7 years old. Genotyping analysis of ERCC1 (C>A, rs3212986), XRCC1 (A>G, rs25487) and GSTP (A>G, rs1695) were performed which allele frequencies were found at 35.6%, 28.9% and 10.6%, respectively. …
Adverse Events Of Antiretroviral Prophylaxis Regimen For Elimination And Prevention Of Mother-To-Child Transmission Among Hiv-Exposed Infants, Suvaporn Anugulruengkitt
Adverse Events Of Antiretroviral Prophylaxis Regimen For Elimination And Prevention Of Mother-To-Child Transmission Among Hiv-Exposed Infants, Suvaporn Anugulruengkitt
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Triple-drug antiretroviral prophylaxis of zidovudine (ZDV)/lamivudine (3TC)/nevirapine (NVP) for high risk HIV-exposed neonates is recommended within the Thai national program. However, there are limited data about the safety and drug concentration achieved with this regimen initiated at birth.
Objectives: This study aims to evaluate the safety of this triple drug neonatal prophylaxis regimen and to describe nevirapine concentration levels during the first 4 weeks of life.
Methods: A prospective cohort of HIV-exposed infants was conducted at 5 clinical sites in Thailand. We enrolled 100 high-risk HIV-exposed neonates (maternal HIV RNA >50 copies/mL prior to delivery or received antiretroviral therapy …
Neurodevelopmental And Neurobehavioral Outcomes In Early Antiretroviral Treated Young Children With Perinatally-Acquired Hiv Infection (Phiv) Compared To Age-Matched Perinatally Hiv-Exposed Uninfected Children (Pheu), Watsamon Jantarabenjakul
Neurodevelopmental And Neurobehavioral Outcomes In Early Antiretroviral Treated Young Children With Perinatally-Acquired Hiv Infection (Phiv) Compared To Age-Matched Perinatally Hiv-Exposed Uninfected Children (Pheu), Watsamon Jantarabenjakul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Introduction: Although early initiation of antiretroviral therapy (ART) in perinatally HIV infected (PHIV) infants significantly reduces morbidity and mortality, neurodevelopmental and neurobehavioral problems are still issues of concern. Objectives: This study aims primarily to compare neurodevelopmental outcomes and neurobehavioral outcomes between PHIV children who initiated ART within 12 months of life and perinatally HIV-exposed uninfected (PHEU) children. The secondary aims are to assess the outcomes by timing of ART initiation and to delineate factors and predictors associated with neurodevelopmental and neurobehavioral outcomes. Methods: This study was a prospective observational study which enrolled PHIV and PHEU children aged 12-56 months. Neurodevelopmental …
Effectiveness And Safety Of Intense Pulsed Light In Patients With Meibomian Gland Dysfunction, Yonrawee Piyacomn
Effectiveness And Safety Of Intense Pulsed Light In Patients With Meibomian Gland Dysfunction, Yonrawee Piyacomn
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study aimed to study the clinical effects and safety in terms of symptoms and signs and to evaluate the change in tear inflammatory cytokines in meibomian gland dysfunction (MGD) after 3 sessions of Intense Pulsed Light (IPL) in a prospective randomized double-masked sham-controlled clinical trial. Patients with MGD who met all criteria were randomly assigned into IPL and sham-IPL group. The stratified blocked randomization was done using the MGD gradeas a stratum by computer-generated assistance. Each patient in IPL group underwent 3 sessions of IPL on day 0, 15 and 45. The other group underwent sham-IPL. Both group received …
Multi-Paths Quest Generation For Structural Analysis, Thongtham Chongmesuk
Multi-Paths Quest Generation For Structural Analysis, Thongtham Chongmesuk
Chulalongkorn University Theses and Dissertations (Chula ETD)
Existing quest generation systems that used quest structures had an important limitation. They were not compatible with dynamic environment games, where player actions may have unforeseen repercussion from chain-reaction, such as locking the quest or preventing it from being completed. In addition, quests generated by such systems were not guaranteed to have multiple completion paths.
In this thesis, action-based-objective quests were replaced with game state-based-objective quests, while retaining the previous grammar rule. Each quest's contents and objectives were filled using Token system and Full Condition State system to ensure the connectivity within the quest's contents and to prevent players from …
Spark Steaming Framework For Large-Scale Multi-Stream Data Analytics, Tanwa Sirisakdiwan
Spark Steaming Framework For Large-Scale Multi-Stream Data Analytics, Tanwa Sirisakdiwan
Chulalongkorn University Theses and Dissertations (Chula ETD)
Real-time streaming applications with multiple heterogeneous data streams have become increasingly popular especially in IoT applications where huge amount of sensors produce large amount of data in the form of data streams. However, many issues still exist, especially in deploying and maintaining these large amounts of data streams. Using Spark Structured Streaming, this research introduces a Spark Streaming framework for multiple heterogeneous data streams which focuses on the ease of deployment and proper scheduling. Our proposed framework is a library that allows the deployment of multiple heterogeneous data stream processing in a single Spark application. Our framework can reduce deployment …
Socio - Economic Determinants Of Teen Pregnancies In Mozambique, Arnaldo Timoteo Mandlate
Socio - Economic Determinants Of Teen Pregnancies In Mozambique, Arnaldo Timoteo Mandlate
Chulalongkorn University Theses and Dissertations (Chula ETD)
Teen pregnancy is considered a worldwide public health issue. According to United Nations Population Fund (2014), Mozambique was reported to be the country with the highest teen pregnancy rate in the Southern Africa region. From 2011 to 2015, the proportion of pregnant teens rose significantly from 38% to 46% (IMASIDA, 2015). Thereby, it is important to study factors leading to teen pregnancy incidence in order to draw policy recommendations in the issue. Previous studies in Mozambique applied a qualitative approach. This study fills the literature gaps using the binary logistic regression with a national cross- sectional dataset provided by IMASIDA-Demographic …