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The Effect Of 1’ Acetoxychavicol Acetate On Cell Proliferation, Metastasis, And Angiogenesis In Human Endocrine-Resistant Breast Cancer Cells, Nalinee Pradubyat
The Effect Of 1’ Acetoxychavicol Acetate On Cell Proliferation, Metastasis, And Angiogenesis In Human Endocrine-Resistant Breast Cancer Cells, Nalinee Pradubyat
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Oestrogen receptor (ER)-positive breast cancer patients have a good prognosis, but 30% of these developed resistance through hyperactivation of PI3K/AKT, ERK1/2, and NFκB, which interconnected with ER signalling. In this study, the effects of 1’ acetoxychavicol acetate (ACA), a plant-metabolite acetate ester compound with an NF-kB inhibitory activity, were investigated in a panel of endocrine-resistant breast cancer cells. Methods: Plant material was purified by chromatographic methods and followed by structural identification using nuclear magnetic resonance and mass spectroscopy. In vitro and in vivo antiproliferative effects of ACA were studied in MCF7/LCC2 and MCF7/LCC9 endocrine-resistant cells using the MTT assay …
Enhanced Propagation Yield Of Influenza Viruses For Vaccine Production Through Cellular Micrornas Regulation, Suthat Saengchoowong
Enhanced Propagation Yield Of Influenza Viruses For Vaccine Production Through Cellular Micrornas Regulation, Suthat Saengchoowong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Annual influenza vaccination aims to prevent influenza virus infection thus reduce the incidence of infection and disease in humans. Nowadays, Madin–Darby canine kidney (MDCK) cell culture-based system has been approved as an alternative for influenza vaccine production. Although cellular microRNAs may play an important role in controlling the replication of viruses, the interaction between human seasonal influenza viruses and host microRNAs has not been investigated in this permissive cell line. The primary objective of this study is to improve the yield of seasonal influenza virus (i.e. vaccine virus) production via manipulation of the host microRNAs. MDCK cells were infected with …
Angiogenic Effect Of Salt-Leached Thai Silk Fibroin Scaffolds With Human Adipose-Derived Stem Cells, Tanapong Watchararot
Angiogenic Effect Of Salt-Leached Thai Silk Fibroin Scaffolds With Human Adipose-Derived Stem Cells, Tanapong Watchararot
Chulalongkorn University Theses and Dissertations (Chula ETD)
Angiogenesis plays important role in tissue regeneration. Biomaterials that allow and promote angiogenesis are thus beneficial. Silk fibroin (SF) scaffolds are good candidates for angiogenesis activation because of the biodegradability, biocompatibility, and interaction of extracellular matrices. Human adipose-derived stem cells (ADSCs) are also promising for tissue regeneration. This study thus aims to investigate the angiogenic potential of SF scaffolds with/without ADSCs on chick chorioallantoic membrane (CAM). Firstly, the SF scaffolds were fabricated with a porosity of 77.34 ± 16.96% and a pore diameter of 513.95 µm. Then, ADSCs were seeded on SF scaffolds (SF-ADSC scaffolds) and placed on CAM on …
Antioxidant And Antibacterial Agents From Parmotrema Dilatatum (Vainio) Hale, Knema Angustifolia (Roxb.) Warb. And Persicaria Odorata Lour, Asshaima Paramita Devi
Antioxidant And Antibacterial Agents From Parmotrema Dilatatum (Vainio) Hale, Knema Angustifolia (Roxb.) Warb. And Persicaria Odorata Lour, Asshaima Paramita Devi
Chulalongkorn University Theses and Dissertations (Chula ETD)
In the search of antioxidant and antibacterial agents, the extracts and isolated compounds from lichen Parmotrema dilatatum, Knema angustifolia full name, Persicaria odorata and Mansonia gagei. were examined. Nine compounds were isolated from lichen P. dilatatum including (E)-2,4-dihydroxy-6-methyl-3-(3-oxobut-1-en-1-yl)benzoate (PD.1), hopane-16ß,22-diol (PD.2), methyl orsellinate (PD.3), methyl haemmatomate (PD.4), methyl ß-orcinolcarboxylate (PD.5), 2-hydroxy-4-methoxy-3,6-dimethylbenzoic acid (PD.6), atranol (PD.7), atranorin (PD.8) and lecanorin (PD.9). The dichloromethane and acetone fractions, and atranol (PD.7) gave excellent activities as antioxidants. While in tyrosinase activity the dichloromethane fraction and atranorin (PD.8) showed the highest inhibition. For α-glucosidase inhibition activity, the methanol fraction and methyl haemmatommate (PD.4) revealed the …
Screening And Identification Of Probiotic Lactic Acid Bacteria From Plant Samplesd, Ratthanatda Nuhwa
Screening And Identification Of Probiotic Lactic Acid Bacteria From Plant Samplesd, Ratthanatda Nuhwa
Chulalongkorn University Theses and Dissertations (Chula ETD)
Seventy lactic acid bacteria (LAB) were isolated from flowers (17 strains), 3 tree barks (7 strains), one fruit (2 strains), ten fermented tea leaves (31 strains) and two silage (13 strains). They were identified as Lactobacillus pentosus (12 strains), L. plantarum subsp. plantarum (9 strains), L. paracasei subsp. tolerans (5 strains), L. brevis (1 strain), L. silagincola (1 strain), L. kunkeei (1 strain), and L. formosensis (1 strain), Enterococcus durans (3 strains), E. lactis (2 strains), E. faecalis (1 strain), E. faecium (1 strain), E. gallinarum (1 strain) and E. gilvus (1 strain), Pediococcus acidilactici (1 strain) and P. pentosaceus …
Development Of Oxidase Enzyme And Non-Enzyme Based Biosensors For Lactate And Creatinine Detection, Siraprapa Boobphahom
Development Of Oxidase Enzyme And Non-Enzyme Based Biosensors For Lactate And Creatinine Detection, Siraprapa Boobphahom
Chulalongkorn University Theses and Dissertations (Chula ETD)
This dissertation focused on the development of electrochemical sensors based on metal oxides and graphene modified electrodes for clinical applications, which is divided into two parts. The first part is development of a biosensor based on lactate oxidase (LOx) immobilized on titanium dioxide sol (TiO2 sol)/graphene nanocomposite modified nickel (Ni) foam electrode for enzymatic electrochemical detection of lactate via hydrogen peroxide (H2O2) detection. A TiO2/graphene nanocomposite was simply synthesized by hydrolysis and coated on Ni foam electrode to develop a novel electrode in biosensor. The results showed that the well intercalation of TiO2 sol within graphene film covered on the …
B2c Online Dispute Resolution (Odr) Legal Frameworkfor Myanmar, Nwe Ni Htun
B2c Online Dispute Resolution (Odr) Legal Frameworkfor Myanmar, Nwe Ni Htun
Chulalongkorn University Theses and Dissertations (Chula ETD)
This thesis examines the applicability of ODR mechanism for consumer disputes in Myanmar especially cross-border disputes. The paper consists of introduction; three main parts and a conclusion. The effect is the appearance of ODR and understanding of what is meant by ODR, how it works and why ODR is needed for consumer. It concludes the review of ODR by both information and communication technology (ICT) and legal view. The paper focuses on case study analysis and compares the legal framework; institutions based on the problem analysis form each case of ODR in the EU and Myanmar. Moreover why use ODR …
Challenges Of Excise Tax Reform In Myanmar : Illegal Alcohol Market And Method Of Charging On Alcoholic Beverages, Ngu Wah Maung
Challenges Of Excise Tax Reform In Myanmar : Illegal Alcohol Market And Method Of Charging On Alcoholic Beverages, Ngu Wah Maung
Chulalongkorn University Theses and Dissertations (Chula ETD)
Myanmar excise tax system is started from the British colonial regime. Excise tax system of Myanmar is complex and different from the other country. Myanmar excise tax system was reformed in several times. Before 2016, alcohol tax was collected as commercial tax. In 2016, the Specific Goods Tax Law was enacted and excise tax for alcoholic beverages has been named as specific goods tax under this law. According to this law excise tax was collected as specific goods tax. Reducing the alcohol consumption is one of the purposes of this law. This thesis analyses weaknesses of Myanmar excise tax system …
Development Of Bioplastic Blown Films To Be Used As A Packaging For Dried Banana, Apinya Wongthanaroj
Development Of Bioplastic Blown Films To Be Used As A Packaging For Dried Banana, Apinya Wongthanaroj
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research aimed to study effects of poly(butylene adipate-co-terephthalate) (PBAT) contents on properties of polylactic acid / poly(hydroxybutyrate-co-hydroxyvalerate) / poly (butylene adipate-co-terephthalate) (PLA/PHBV/PBAT) blends to be used as a packaging for solar-dried bananas. The blend of PLA and PHBV (PLA/PHBV) was fixed at weight ratio of 80/20 while the PBAT content was varied from 0-30 wt%. The films were prepared by melt compounding and blown film extrusion. It was found that the addition of PBAT decreased barrier properties of PLA/PHBV film. Gas barrier which is oxygen transmission rate (OTR) and water vapor transmission rate (WVTR) increased with increasing of PBAT …
Study Of Co2 And Bi-Reforming Of Methane On Modified Nickel-Based Catalysts, Nichakorn Buasuk
Study Of Co2 And Bi-Reforming Of Methane On Modified Nickel-Based Catalysts, Nichakorn Buasuk
Chulalongkorn University Theses and Dissertations (Chula ETD)
Nowadays, several currently operated industrial factories significantly increase the rate of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) far higher than those that should be normally. Therefore, various mitigation ways to reduce carbon dioxide and methane are increasingly important. The prevailing methods are dry reforming of methane and bi-reforming of methane. Therefore, this research involves the study of the catalytic activity and coke resistance on the Ni-based catalysts with and without a promoter. The activity tests on the dry reforming of methane reaction and bi-reforming of methane reaction were performed in a fixed-bed reactor under atmospheric pressure at …
Development And Characterization Of Natural Rubber-Cellulose Sponge, Nuttapon Suppanucroa
Development And Characterization Of Natural Rubber-Cellulose Sponge, Nuttapon Suppanucroa
Chulalongkorn University Theses and Dissertations (Chula ETD)
Natural rubber (NR) sponges are a renewable biopolymer material derived from milky sap (latex) from rubber trees. In this study, composite sponges of natural rubber and cellulose (NR-C) with various compositions were synthesized. The Dunlop process was employed to prepare the NR-C sponges in various contents of cellulose fibers as reinforcing agent. The cellulose fibers were extracted from the pulp of eucalyptus trees and sodium alginate (SA) was used as dispersing agent. The aim of this work was to develop a green composite sponge with highly porous, flexible, and hydrophilic properties. The effects of cellulose loading on mechanical performance of …
Molecular Dynamics Simulation Of Phenolic Compound Adsorption On Amine-Functionalized Carbon Nanotubes, Nutapong Tanatananon
Molecular Dynamics Simulation Of Phenolic Compound Adsorption On Amine-Functionalized Carbon Nanotubes, Nutapong Tanatananon
Chulalongkorn University Theses and Dissertations (Chula ETD)
The interactions between green tea phenolic compounds, including (−)-epigallocatechin gallate (EGCG) and (−)-epigallocatechin (EGC), and various amine groups functionalized on carbon nanotube (CNT) were studied by all-atom molecular dynamics (MD) simulations. The amine functional groups: ethylenediamine (EDA), triethylenetetramine (TETA), and melamine (MA) were considered in this study. Simulated results showed that amine molecular structure grafted on CNT surface affected diffusion and adsorption of EGCG and EGC. The EDA-functionalized CNT (EDA/CNT) provided a strong adsorption affinity to EGCG and EGC with their bicyclic segments located within the EDA layer. It is because the functionalized-EDA structure was well-defined and given empty site …
Chemical Constituents Of Knema Angustifolia Stem And Biological Activities, Dung Le Thi Kim
Chemical Constituents Of Knema Angustifolia Stem And Biological Activities, Dung Le Thi Kim
Chulalongkorn University Theses and Dissertations (Chula ETD)
The medicinal plant Knema angustifolia has been used in Thai folk medicine for the treatment of various diseases, especially related to body tonic or blood tonic agent. Chemical data on this plant are scarce. A novel para-benzoquinone, angustiquinone (3), along with ten known compounds, rapanone (1), embelin (2), quercetin (4), kaempferol (5), bergenin (6), 11-O-acetyl bergenin (7), catechin (8), isovanillic acid (9), protocatechuic acid (10) and gallic acid (11) were isolated from the n-hexane and EtOAc extracts of the stems of K. angustifolia. Their structures were unambiguously elucidated using extensive 1D and 2D NMR analyses, high-resolution mass spectrometry along with …
Development Of Portable Electrochemical Sensors For Determination Of Heavy Metals, Nitrogen Oxides And Thiocyanate Ion, Kingkan Pungjunun
Development Of Portable Electrochemical Sensors For Determination Of Heavy Metals, Nitrogen Oxides And Thiocyanate Ion, Kingkan Pungjunun
Chulalongkorn University Theses and Dissertations (Chula ETD)
This dissertation focused on the development of portable electrochemical sensors using the paper-based analytical device (ePAD) for the determination of the important compounds/biomarkers in various applications. Considering the target applications, this dissertation can be divided into three main parts including food safety application, environmental analysis and clinical application, respectively. In the first part, two sub-sections relating to the detection of heavy metals contaminated in food will be discussed. For the first sub-section, an ePAD coupled with a boron-doped diamond electrode was developed for the determination of total arsenic. The device was performed using the origami paper device for the preparation …
Synthesis Of Chalcone Derivatives As Ampk Activators, Duy Vu Nguyen
Synthesis Of Chalcone Derivatives As Ampk Activators, Duy Vu Nguyen
Chulalongkorn University Theses and Dissertations (Chula ETD)
Diabetes and diabetic nephropathy are two noticeable disorders in modern life. Chalcones are considered as a feasible candidate for these medication disorders due to the capability to activate AMPK relating to these two diseases. A series of chalcones with A-ring possessing 2'-hydroxy-, 3',4',5'-trimethoxyacetophenones or other types and B-ring decorated with mono-, di-, trisubstitution were accomplished by Claisen–Schmidt, etherification and hydrogenation reactions in almost moderate to high yield. 3-Methoxy group was found to be the best substituent for the activity in case of monosubstitution on B-ring. 3,4-Dimethoxy and 3,4-methylenedioxy groups on B-ring (63 and 65) enhanced the activity of disubstituted chalcones …
Development Of Sensing Platforms Using Bulk Optode Technique For Detection Of Silver And Mercury Ions, Manoon Phichi
Development Of Sensing Platforms Using Bulk Optode Technique For Detection Of Silver And Mercury Ions, Manoon Phichi
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research described new analytical devices for Ag+ and Hg2+ detection using bulk optode technique. The optode containing 25,27-di(benzothiazolyl)-26,28-hydroxycalix[4]arene (CU1) as an ion-selective ionophore, chromoionophore XIV as a lipophilic pH indicator, and KTpClPB as an ion-exchanger was prepared and used as a sensing agent in the proposed devices. The optode sensors responded to Ag+ and Hg2+ by changing the color from blue to yellow. The colorimetric-based detection was carried out by using the proposed paper-based analytical device. A simple fabrication method was performed by simply dropping the cocktail onto the filter paper, and the detection method was easily performed by …
Chemical Constituents From The Stems Of Garcinia Cylindrocarpa And The Stem Bark Of Garcinia Picrorhiza And Garcinia Tetrandra, Edwin Risky Sukandar
Chemical Constituents From The Stems Of Garcinia Cylindrocarpa And The Stem Bark Of Garcinia Picrorhiza And Garcinia Tetrandra, Edwin Risky Sukandar
Chulalongkorn University Theses and Dissertations (Chula ETD)
Aiming to discover novel bioactive secondary metabolites from genus Garcinia, we performed phytochemical and biological investigations of three Garcinia species collected from Indonesia. A series of chromatographic techniques and spectroscopic data analysis were used to isolate and characterize the Garcinia phytochemicals. The cytotoxicity of the isolated compounds was evaluated against five human cancer cell lines (HeLa S3, Hep G2, HT-29, MCF-7, and KB) using MTT assay. Four new xanthones, cylindroxanthones D–G, and two new biphenyls, cylindrobiphenyls A and B, together with 28 known compounds were successfully isolated from G. cylindrocarpa stems. From the stem bark of G. tetrandra, nine new …
Development Of Biosensor Using Pyrrolidinyl Pna For Screening Of Hepatitis C Virus Dna, Narathorn Nisab
Development Of Biosensor Using Pyrrolidinyl Pna For Screening Of Hepatitis C Virus Dna, Narathorn Nisab
Chulalongkorn University Theses and Dissertations (Chula ETD)
In this work, a new paper-based analytical device (PAD) that relied on fluorescence measurement was developed for label-free detection of hepatitis C virus (HCV) DNA. Pyrrolidinyl peptide nucleic acid (acpcPNA) was covalently modified onto the patterned cellulose paper to act as a specific probe for capturing the HCV DNA target according to Watson−Crick base-paring rules. The single-stranded (ssDNA)-specific dye which can be electrostatically attached to the surface-bound DNA was employed as the signaling element for the fluorescence-based detection via a smartphone gadget and an iOS application. To acquire the optimal sensitivity, several experimental parameters, namely acpcPNA probe concentration, hybridization time, …
Chemical Constituents And Antibacterial Activity Of Rhizomes From Globba Schomburgkii Hook.F., Naruemon Suekaew
Chemical Constituents And Antibacterial Activity Of Rhizomes From Globba Schomburgkii Hook.F., Naruemon Suekaew
Chulalongkorn University Theses and Dissertations (Chula ETD)
Globba schomburgkii Hook.f. rhizomes were extracted with dichloromethane and fractionated using column chromatography to obtain 10 fractions (FA-FJ). The most active fractions, FE and FG, were further fractionated to give seven and thirteen sub-fractions, respectively. The fractions and sub-fractions were tested for antibacterial activity using 96-well plate microdilution method. The antibacterial activity of several sub-fractions (such as FE.B, FE.C, FE.D, FG.D, FG.G, and FG.H) were higher than that of the crude extract. Chemical compositions of all fractions and sub-fractions were analyzed by gas chromatography hyphenated with mass spectrometry (GC-MS), revealing 167 compounds identified according to match between the experimental MS …
Detection Of Nitrite By Thread-Based And Paper-Based Devices By Modified Griess Reagent, Pitcha Singhaphan
Detection Of Nitrite By Thread-Based And Paper-Based Devices By Modified Griess Reagent, Pitcha Singhaphan
Chulalongkorn University Theses and Dissertations (Chula ETD)
New thread-based and paper-based devices for the determination of nitrite ions based on modified Griess reagent were developed. The surface of the materials was chemically modified with p-aminobenzoyl moiety and chromotropic acid was used as a coupling reagent. The functionalization of the materials was confirmed by Raman spectroscopy. By using the thread-based device, the detection of nitrite was achieved by measuring the color band length. The optimum concentration of chromotropic acid was 5 mM in 0.10 M sulfuric acid mixed with 0.2 M citric acid. The working range was from 50 to 1,000 µM with a sample volume of 15 …
Detection Of Cyanide Ions Using Chemosensing Ensembles Under Indicator Displacement Assays, Ratanakorn Teerasarunyanon
Detection Of Cyanide Ions Using Chemosensing Ensembles Under Indicator Displacement Assays, Ratanakorn Teerasarunyanon
Chulalongkorn University Theses and Dissertations (Chula ETD)
Anion recognition is an attractive area of research in recent decades as anions play an important role in a wide range of chemical, biological, and environmental processes. This dissertation reports three projects dedicated to anion recognition with applications in fluoride and cyanide sensing. The first project of the dissertation describes the chemistry of two novel anthracene derivatives bearing one and two dimesitylboryl substituents (compounds 1 and 2, respectively) for the complexation of anions. All investigations provide insights into the electronic structure and effect of fluoride and cyanide binding. The results demonstrate that these boranes have a high affinity for fluoride …
Development Of Paper-Based Colorimetric Sensor For Determination Of Human Papillomavirus Dna, Sarida Naorungroj
Development Of Paper-Based Colorimetric Sensor For Determination Of Human Papillomavirus Dna, Sarida Naorungroj
Chulalongkorn University Theses and Dissertations (Chula ETD)
In this work, a paper-based analytical device (PAD) based on colorimetric assay using pyrrolidinyl peptide nucleic acid (acpcPNA) probe was developed as a sensor for the detection of Human papillomavirus (HPV) DNA. Dextrin-stabilized gold nanoparticles (d-AuNPs) was employed as a colorimetric reagent. The aggregation of d-AuNPs can be induced by positively charged acpcPNA generating a distinctive color change. After the hybridization of acpcPNA and DNA target, the residual acpcPNA probe can cause different degrees of the d-AuNPs aggregation, resulting in the detectable color change. The different color change before and after the introduction of the DNA target as a function …
Development Of Fluorinated Rhodacyanine Analogues For Anti-Leishmaniasis, Thitiya Lasing
Development Of Fluorinated Rhodacyanine Analogues For Anti-Leishmaniasis, Thitiya Lasing
Chulalongkorn University Theses and Dissertations (Chula ETD)
Recently, fluorinated rhodacyanine has been disclosed as a highly effective agent against Leishmania donovani; it was shown that replacement of hydrogen with a fluorine atom on a benzothiazole unit significantly enhanced the anti-leishmanial activity. However, the role of the fluorine substituent in this analogue has not yet been clarified and mechanism of actions remains unclear. In this research, fifteen novel and three known fluorine-containing rhodacyanine analogues (10c, and 11a-11q) were synthesized and tested the anti-leishmanial activity against promastigote and axenic amastigote stages of L. martiniquensis and L. orientalis, the indigenous Leishmania species of Thailand. The SAR knowledge of this series …
Synthesis Of Coumarins As Carbonic Anhydrase Ii And Α-Glucosidase Inhibitors, Truc Phan Thi Hong
Synthesis Of Coumarins As Carbonic Anhydrase Ii And Α-Glucosidase Inhibitors, Truc Phan Thi Hong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Coumarins have been occupied an important position in medicinal chemistry. In this research, umbelliferone derivatives were evaluated for inhibitory activity of two enzymes, namely carbonic anhydrase II (CA II) and α-glucosidase. First, ether, brominated ether and ester derivatives of umbelliferone were synthesized, characterized and tested for CA II inhibitory activity. However, the inhibition data could not be used to make the exact conclusion about structure-activity relationship owing to their unrepeatable results. For the second part, thirty-four derivatives of umbelliferone (ether, brominated ether, ester, sulfonamide and sulfonate derivatives) were synthesized and explored for anti-α-glucosidase activity. It was disclosed that anti-α-glucosidase activity …
Development Of Paper-Based 3d Cell Culture Devices And Real-Time Biosensing Applications, Naricha Pupinyo
Development Of Paper-Based 3d Cell Culture Devices And Real-Time Biosensing Applications, Naricha Pupinyo
Chulalongkorn University Theses and Dissertations (Chula ETD)
Due to its micro fibrous pores, paper has gained traction in the use as a scaffold for 3D cell culture. To study melanoma mechanism, screening the amount of melanin production and invasion study are major keys for drug development. In this work, we developed paper-based devices for culturing melanoma cells. Through the development process, we obtained the optimal parameters, which were applied for 3 different projects; 1) Anti-melanogenic effect screening, 2) Impedance-based E-screen assay, and 3) A membrane insert for real-time invasion assay. As a result of melanin production from melanocytes, the cells can be easily observed after a few …
Effects And Mechanisms Of Caesalpinia Mimosoides Leaf Extract On Oxidative Stress Resistance And Anti-Aging Activity In Caenorhabditis Elegans And Neurite Outgrowth Activity In Neuro2a Cells, Panthakarn Rangsinth
Effects And Mechanisms Of Caesalpinia Mimosoides Leaf Extract On Oxidative Stress Resistance And Anti-Aging Activity In Caenorhabditis Elegans And Neurite Outgrowth Activity In Neuro2a Cells, Panthakarn Rangsinth
Chulalongkorn University Theses and Dissertations (Chula ETD)
World’s population of older people is rising, dietary supplements promoting healthy lifespan are needed. Moreover, Alzheimer’s disease (AD), an age-related degenerative disease, becomes a public health problem in aging society. Recent reports using cell culture models of AD suggest that amyloid precursor protein (APP), a protein causally related to AD, plays an important role as an inhibitor of neurite outgrowth. Medicinal herbs with neurite outgrowth stimulatory effect may help to prevent and cure AD. Moreover, studies suggest that dietary supplements from plant sources act in preventive nutrition, since they provide antioxidant action against oxidative stress, promote healthspan and prolong lifespan. …
Population Pharmacokinetics Of Nicotine In Thai Smokers, Kathy Moe San
Population Pharmacokinetics Of Nicotine In Thai Smokers, Kathy Moe San
Chulalongkorn University Theses and Dissertations (Chula ETD)
Despite the popularity of nicotine gum in Thailand, population pharmacokinetics of nicotine gum in Thai population has not been investigated yet. This study aimed to develop a population pharmacokinetic model to quantify the effects of genetic and nongenetic factors to nicotine pharmacokinetics after administration of nicotine gum to adult Thai smokers. A population pharmacokinetic analysis was performed using secondary data collected from a previous clinical trial assessing cytochrome P450 2A6 (CYP2A6) genotypes in Thai smokers. Eighteen healthy adult smokers were included in the study. Blood samples were collected at pre-dose, and 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4.5, and …
Qualitative Analysis Of Optic Nerve Head Peripapillary Microvasculature In Healthy Eyes Using Optical Coherence Tomography Angiography, Sittikorn Laojaroenwanit
Qualitative Analysis Of Optic Nerve Head Peripapillary Microvasculature In Healthy Eyes Using Optical Coherence Tomography Angiography, Sittikorn Laojaroenwanit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Primary objective: To evaluate optic nerve head microvasculature/radial peripapillary capillaries (RPCs) in healthy adult eyes using swept-source optical coherence tomography angiography Secondary objectives: To evaluate macular microvascular network in healthy adult eyes using swept-source optical coherence tomography angiography Design: Cross-sectional study Participants: 224 eyes of 112 healthy adult volunteers at eye clinic of King Chulalongkorn Memorial Hospital. Method: En face 3x3-mm OCTA at macular area, 6x6-mm OCTA at optic nerve head and high-definition horizontal lines 16-mm scans crossing the fovea and optic disc were acquired using the SS-OCTA Plex Elite 9000. To evaluate RPCs density, the images were binarized and …
An Affordable Immunohistochemical Approach To Estimate The Prevalence Of Braf V600e Mutation In Papillary Thyroid Cancer Patients Of King Chulalongkorn Memorial Hospital, Thailand., Sonam Choden
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Papillary thyroid carcinoma (PTC) accounts for the majority of diagnoses of thyroid carcinoma. BRAFV600E mutation is the most common genetic alteration in PTC, which has diagnostic and prognostic significance. The rate of BRAFV600E mutation in PTC from Thailand has not been reported. Our purpose was to estimate the prevalence of BRAF mutation in a large institutional series using an affordable approach, which combined mutation-specific immunohistochemistry (IHC) with VE1 antibody and tissue microarray (TMA). Methods: A total of 476 PTC cases plotted on TMA were employed for determining the mutation status in this study. The cancer tissue of initial 100 …
Predictive Factors For Invasive Fungal Rhinosinusitis In Diabetic Patients, Thwe Phyo Kan Nyunt
Predictive Factors For Invasive Fungal Rhinosinusitis In Diabetic Patients, Thwe Phyo Kan Nyunt
Chulalongkorn University Theses and Dissertations (Chula ETD)
ภูมิหลัง ผู้ป่วยเบาหวานมีโอกาสที่จะเกิดโรคไซนัสอักสบจากเชื้อราชนิดรุกรานได้ง่ายกว่าผู้ป่วยปกติ ซึ่งอัตราการเสียชีวิตจากโรคนี้ในผู้ป่วยเบาหวานมีความหลากหลายค่อนข้างสูงในแต่ละการศึษา วัตถุประสงค์ เพื่อศึกษาปัจจัยที่จะทำนายอัตราการรอดชีวิตของผู้ป่วยเบาหวานที่เกิดโรคไซนัสอักสบจากเชื้อราชนิดรุกราน วิธีการศึกษา การศึกษาแบบย้อนหลังนี้ได้จัดทำในโรงพยาบาลระดับตติยภูมิ 4 แห่ง ในประเทศไทย, มาเลเซีย และเมียนมาร์ โดยเก็บรวบรวมข้อมูลในผู้ป่วยเบาหวานที่เกิดโรคไซนัสอักสบจากเชื้อราชนิดรุกราน ตั้งแต่ปี ค.ศ. 2008 ถึง ค.ศ.2019 ผลที่ต้องการศึกษาคืออัตราการรอดชีวิต ปัจจัยทำนายที่นำมาวิเคราะห์ ได้แก่ อายุ, ระดับฮีโมโกลบินเอวันซีในเลือด, ภาวะเลือดเป็นกรดคีโต, ระดับเม็ดเลือดขาว, ภาวะน้ำตาลในเลือดสูง, ระยะเวลาที่เป็นโรคเบาหวาน, การใช้ยารักษาเบาหวานในปัจจุบัน, ระดับครีเอทีนีนในเลือด, และการกระจายของโรคไซนัสอักสบจากเชื้อราชนิดรุกรานเข้าไปที่ตา, คาเวอร์นัสไซนัส และโพรงสมอง ผลการศึกษา มีการเก็บรวบรวมข้อมูลในผู้ป่วยเบาหวานที่เกิดโรคไซนัสอักสบจากเชื้อราชนิดรุกราน 65 ราย (อายุเฉลี่ย 57.9±13.4 ปี, เพศชาย 60%) ผลพบว่า อัตราการเสียชีวิตอยู่ที่ 21.5 % โดยพบว่าการกระจายของโรคไซนัสอักสบจากเชื้อราชนิดรุกรานเข้าคาเวอร์นัส ไซนัส (hazard ratio 5.1, 95% CI [1.4–18.2], p=0.01) และโพรงสมอง (hazard ratio 3.4, 95% CI [1.1–11.3], p=0.05) เป็นปัจจัยทำนายอัตราการเสียชีวิต ส่วนการรักษาเบาหวานเป็นปัจจัยที่ลดความเสี่ยงของการเสียชีวิต (hazard ratio 0.2, 95% CI [0.1–0.9], p=0.03) ด้านอัตราการรอดชีวิตในระยะเวลา 6 เดือนในผู้ป่วยที่มีการกระจายของโรคไซนัสอักสบจากเชื้อราชนิดรุกรานเข้าไปและไม่เข้าไปที่คาเวอร์นัสไซนัสอยู่ที่ 51.4% และ 83.6% ตามลำดับ, (p <0.01), เข้าไปและไม่เข้าไปที่โพรงสมองอยู่ที่ 53.3% และ 88.9% ตามลำดับ, (p <0.01) และมีการใช้ยารักษาเบาหวานและไม่มีการใช้ยารักษาเบาหวานอยู่ที่ 82.3% และ 57.5% ตามลำดับ, (p =0.05) สรุป การกระจายของโรคไซนัสอักสบจากเชื้อราชนิดรุกรานเข้าไปที่คาเวอร์นัสไซนัสและโพรงสมองเพิ่มความเสี่ยงต่อการเสียชีวิตในผู้ป่วยเบาหวาน การรอดชีวิตมีความสัมพันธ์กับการใช้ยารักษาเบาหวานในปัจจุบัน