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การแปรของวัจนลีลากับการประกอบสร้างอัตลักษณ์ของอินฟลูเอนเซอร์ชาวไทย: กรณีศึกษาไพรวัลย์ วรรณบุตร, กันตวัฒน์ ก้องวิญญู
การแปรของวัจนลีลากับการประกอบสร้างอัตลักษณ์ของอินฟลูเอนเซอร์ชาวไทย: กรณีศึกษาไพรวัลย์ วรรณบุตร, กันตวัฒน์ ก้องวิญญู
Chulalongkorn University Theses and Dissertations (Chula ETD)
วิทยานิพนธ์ฉบับนี้มีวัตถุประสงค์เพื่อศึกษาการแปรของวัจนลีลาที่ไพรวัลย์ วรรณบุตร หรือแพรรี่ อินฟลูเอนเซอร์ชาวไทยใช้ ซึ่งในอดีตเป็นพระภิกษุ ต่อมาได้ลาสิกขา แสดงออกว่าเป็นผู้มีความหลากหลายทางเพศ และมีชื่อเสียงต่อไปบนสื่อสังคม โดยวิเคราะห์ข้อมูลจากการถ่ายทอดสดบนเฟซบุ๊กในช่วงเวลาที่มีการเปลี่ยนผ่านด้านเพศสภาวะจากการแสดงออกเป็นชายไปสู่การแสดงออกเป็นหญิง คือ ปี 2565 มีวัตถุประสงค์เพื่อศึกษาการแปรทางศัพท์และเสียงที่ไพรวัลย์ วรรณบุตรใช้ในช่วงเวลาที่มีการแสดงตัวตนที่แตกต่างกัน และเพื่อวิเคราะห์ความเชื่อมโยงระหว่างลักษณะทางภาษากับการประกอบสร้างอัตลักษณ์ของไพรวัลย์ วรรณบุตร ผลการศึกษา ด้านการแปรทางศัพท์ 4 ตัวแปร ได้แก่ คำอ้างถึงตนเอง คำเรียกขาน อนุภาคลงท้าย และวงศัพท์ พบว่าแพรรี่ใช้ตัวแปรศัพท์แตกต่างกัน โดยมีการแปรที่เป็นไปตามเพศสภาวะ คือ คำอ้างถึงตนเองและอนุภาคลงท้าย ในช่วงที่ 1 พบการใช้คำอ้างถึงตนเองแสดงความเป็นชายสูงสุด ทว่าพบการใช้อนุภาคลงท้ายแสดงความเป็นชายพอ ๆ กับที่ไม่ระบุเพศ ในช่วงที่ 3 พบการใช้คำอ้างถึงตนเองและอนุภาคลงท้ายแสดงความเป็นหญิงสูงสุด ในช่วงที่ 2 พบการใช้คำอ้างถึงตนเองและอนุภาคลงท้ายแสดงความเป็นชายลดลงจากช่วงที่ 1 ส่วนคำเรียกขานและวงศัพท์ ไม่มีการแปรที่เป็นไปตามเพศสภาวะ มีแต่การแปรที่เป็นไปตามสถานการณ์การสื่อสาร โดยคำเรียกขานที่แพรรี่ใช้มากที่สุดในแต่ละช่วงนั้นเป็นคำที่ต่างกัน คือ “พี่” ในช่วงที่ 1 “คุณ” ในช่วงที่ 2 “มึง” ในช่วงที่ 3 ขณะที่วงศัพท์นั้น ศัพท์ทางพุทธศาสนาถูกใช้เพื่อแสดงทีท่าเชิงความรู้โดยตลอด ไม่เพียงเท่านั้น ยังแสดงทีท่าเชิงอำนาจ ทีท่าเชิงความหนักแน่น และทีท่าเชิงความรู้สึก ด้านการแปรทางเสียง 3 ตัวแปร ได้แก่ ระดับเสียงโดยรวม ความแปรปรวนระดับเสียง และพิสัยระดับเสียง ก็พบว่าแพรรี่ใช้ตัวแปรเสียงแตกต่างกัน แต่ไม่มีทิศทางที่เป็นไปตามเพศสภาวะ คือ ตัวแปรทางเสียงข้างต้นมีค่าสูงที่สุดเมื่อแพรรี่แสดงความเป็นชาย ในจำนวนนี้ มีเพียงระดับเสียงโดยรวมเท่านั้นที่สูงขึ้นอย่างมีนัยสำคัญทางสถิติ ภายหลังจากการเปลี่ยนผ่านสภาวะทางเพศกระทั่งแสดงความเป็นหญิง ส่วนความแปรปรวนและพิสัยระดับเสียงนั้น สูงและกว้างขึ้นแต่ไม่มีนัยสำคัญทางสถิติ มิเพียงแต่ทีท่าข้างต้น การแปรทางศัพท์และเสียงยังแสดงให้เห็นทีท่าอื่น ๆ อีก คือ ทีท่าความสนิทสนม และทีท่าความอ่อนน้อม รวมเป็น 6 ทีท่า โดยที่ทีท่ารวมกันบ่งชี้บุคลิกได้ 2 บุคลิก คือ บุคลิกของผู้มีการศึกษา และบุคลิกของผู้ขายสินค้า ผลการศึกษาแสดงให้เห็นว่า อัตลักษณ์ของแพรรี่ไม่ได้เป็นสิ่งตายตัว ยากที่จะสรุปได้ เพราะเป็นสิ่งที่สามารถประกอบสร้างได้อย่างต่อเนื่องผ่านการใช้คำและเสียงพูด โดยขึ้นอยู่กับช่วงเวลา เพศสภาวะ …
Challenging Homogenization: Identity In The Design Concepts Of Contemporary High-Rise Architecture In Bangkok, Chalaka Wijenayake
Challenging Homogenization: Identity In The Design Concepts Of Contemporary High-Rise Architecture In Bangkok, Chalaka Wijenayake
Chulalongkorn University Theses and Dissertations (Chula ETD)
The dominance of high-rise architecture in globalized urban landscapes has arguably raised concerns about the homogenization of cities and the decline of local identity. As vertical structures become essential components of contemporary metropolises, they pose unique challenges in negotiating cultural and contextual relevance. While often critiqued for their perceived detachment from place, some high-rises attempt to assert localized identities without reverting to superficial mimicry. This research engages with these tensions by analyzing five high-rise buildings in Bangkok—a vibrant, cosmopolitan, and non-Western urban setting—through the lens of Critical Regionalism, despite its known limitations when applied to large-scale architecture. The study examines …
The Dynamics Of The Chana Community Network Movement: Strategic Shifts, Impacts, And Reflections On Thailand's Political Landscape, Abdullah Yuhannan
The Dynamics Of The Chana Community Network Movement: Strategic Shifts, Impacts, And Reflections On Thailand's Political Landscape, Abdullah Yuhannan
Chulalongkorn University Theses and Dissertations (Chula ETD)
This dissertation examines the dynamics of the Chana Community Movement, one of Thailand’s most enduring grassroots movements. Originating in the early 1990s with opposition to illegal commercial fishing, the movement has evolved to resist the Chana Industrial Estate Project. The research addresses key questions concerning factors sustaining the movement, tactical adaptations, societal impacts, and its reflection of Thailand’s contemporary political landscape. The study employs a qualitative research methodology, combining document analysis, in-depth interviews, and participant observation, alongside analytical frameworks derived from political struggle studies and social movement theories for comprehensive analysis. The findings reveal that the Chana Community Movement succeeded …
Understanding Pluriversal Ontology: The Cases Of Three Alternative Agriculture Communities In Sisaket Province, Northeastern, Thailand, Thita Ornin
Chulalongkorn University Theses and Dissertations (Chula ETD)
In reaction to the global development paradigm, the concept of Pluriverse has played a pivotal role in exploring alternatives to development, aiming to foster a world that accommodates multiple worlding with the goals to facilitate various approaches to collective well-being, moving away from anthropocentric, linear growth within the modern capitalist development. This thesis seeks to understand alternative agriculture cases in the Northeast of Thailand through the Pluriversal ontology conceptual framework and to determine its usefulness through the following proposed framework; (1) alternative agricultural development discourse analysis, (2) friction and assimilation with modernity and (3) post-development values. Taken an inspiration from …
Negotiating Identities: A Transformation Of Thai-Muslim In The Baan Somdej Mosque Community (Bangkok), Vinissa Kattiya-Aree
Negotiating Identities: A Transformation Of Thai-Muslim In The Baan Somdej Mosque Community (Bangkok), Vinissa Kattiya-Aree
Chulalongkorn University Theses and Dissertations (Chula ETD)
Thailand is home to more than 6 million Muslims, making Thai-Muslim the largest religious minority group. Thai – Muslim communities have long been a part of Thai society, participating in all levels of society, from economics to politics. Despite much research written on the Thai Muslim population and communities, the Bangkok Muslim communities remain understudied. This research hopes to expand the existing research on Muslims in Thailand and offer an interdisciplinary explanation focusing on international development and anthropological aspects of the transformation of a Thai Muslim community. This thesis presents a case study of the Muslims of the Baan Somdej …
Thailand's Never-Ending Pesticide Debate: Contested Future Sociotechnical Imaginaries Through A Relational Co-Productionist Lens, Henriette Erawan Kamphorst
Thailand's Never-Ending Pesticide Debate: Contested Future Sociotechnical Imaginaries Through A Relational Co-Productionist Lens, Henriette Erawan Kamphorst
Chulalongkorn University Theses and Dissertations (Chula ETD)
Since the introduction of the Green Revolution, the use of agrochemicals in Thai farming has sparked repeated contentious debates among local policy elites, addressing issues such as consumer health, farmer livelihoods, and environmental degradation. In 2019, this subject re-emerged on the policy agenda with the proposed ban of three key agrochemicals: Chlorpyrifos, Paraquat, and Glyphosate. In order to understand why the pesticide issue has remained on policy actors’ agendas for so long and still continues to be subject to ongoing debate, this research takes on a new perspective by adopting a relational co-productionist approach in the construction of contesting sociotechnical …
Esthetic Evaluation Of Implant Restoration In Esthetic Zone: A Long-Term Follow-Up, Harit Muangmore
Esthetic Evaluation Of Implant Restoration In Esthetic Zone: A Long-Term Follow-Up, Harit Muangmore
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: This study aimed to evaluate the correlation between esthetic outcomes of single-tooth implant restorations (STIRs) in the anterior maxilla, assessed by the Pink Esthetic Score (PES), White Esthetic Score (WES), and the newly introduced Esthetic Sustainable Criteria (ESC), over two follow-up periods: 5 years and 10 years. Materials and Methods: A cross-sectional retrospective study was conducted involving 22 patients treated with STIRs at the Faculty of Dentistry, Chulalongkorn University, from January 2009 to December 2024. Patient demographics, treatment protocols, and follow-up assessments were collected at both 5 and 10 years. PES and WES were utilized to evaluate esthetic outcomes, …
แนวทางการเสริมสร้างความเป็นพลเมืองตื่นรู้บนฐานการเรียนรู้ด้วยการบริการสังคม, บุญญาภา ปานลักษณ์
แนวทางการเสริมสร้างความเป็นพลเมืองตื่นรู้บนฐานการเรียนรู้ด้วยการบริการสังคม, บุญญาภา ปานลักษณ์
Chulalongkorn University Theses and Dissertations (Chula ETD)
การวิจัยครั้งนี้มีวัตถุประสงค์ของการวิจัย 3 ข้อ คือ 1) ศึกษาและพัฒนาเครื่องมือวัดความเป็นพลเมือง ตื่นรู้ 2) ศึกษารูปแบบการจัดการศึกษาที่ส่งผลให้ผู้เรียนมีความเป็นพลเมืองตื่นรู้ และ 3) นำเสนอแนวทางการเสริมสร้างความเป็นพลเมืองตื่นรู้บนฐานการเรียนรู้ด้วยการบริการสังคมโดยใช้ระเบียบวิธีวิจัยแบบผสมผสาน (mixed method research) ประเภท การวิจัยแบบขั้นตอนเชิงอธิบายตามลำดับ (explanatory sequential design) ประชากรที่ใช้ในการวิจัย คือ นักเรียนชั้นมัธยมศึกษาปีที่ 1-3 กลุ่มตัวอย่างได้จากการเลือกแบบเจาะจง จำนวน 456 คน ผู้ให้ข้อมูลสำคัญ (key informants) ประกอบด้วย 4 กลุ่ม ได้แก่ (1) ผู้บริหารสถานศึกษา (2) ครู (3) นักเรียน และ (4) ผู้มีส่วนเกี่ยวข้องกับการจัดการศึกษาของโรงเรียนที่ได้รับรางวัลจากการประกวดโครงการสร้างสำนึกพลเมือง (project citizens) จำนวน 3 แห่ง และ ผู้ทรงคุณวุฒิพิจารณาร่างแนวทางการเสริมสร้างความเป็นพลเมืองตื่นรู้บนฐานการเรียนรู้ด้วยการบริการสังคม จำนวน 10 ท่าน เครื่องมือที่ใช้ในการวิจัย มีแบบสอบถาม แบบสัมภาษณ์กึ่งโครงสร้าง และแบบประเมินร่างแนวทาง สถิติที่ใช้ในการวิจัย คือ ค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน และการวิเคราะห์เนื้อหา ตลอดจนการวิเคราะห์องค์ประกอบเชิงยืนยัน (CFA) ผลการวิจัยพบว่า1) เครื่องมือวัดความเป็นพลเมืองตื่นรู้ที่สร้างขึ้นตามตัวชี้วัดความเป็นพลเมืองตื่นรู้ ประกอบด้วย 14 ตัวชี้วัด จากองค์ประกอบ 3 ด้าน ได้แก่ (1) ด้านความรู้ จำนวน 4 ตัวชี้วัด (2) ด้านทักษะ จำนวน 6 ตัวชี้วัด และ (3) ด้านเจตคติ และค่านิยม จำนวน 4 ตัวชี้วัด เป็นแบบวัดชนิดมาตราส่วนประเมินค่า (rating scale) 5 ระดับ จำนวน 66 ข้อ ที่มีค่าดัชนีความสอดคล้อง …
Mixed-Reality Learning Environment In Studio-Based Learning To Enhance Creative Problem-Solving For Architecture, Thadharphut Limapornvanitr
Mixed-Reality Learning Environment In Studio-Based Learning To Enhance Creative Problem-Solving For Architecture, Thadharphut Limapornvanitr
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research and development aim to 1) address the factor structure of creative problem-solving skills for undergraduate architecture students in Thailand. 2) identify what technology-fostered, mixed-reality learning environment for studio-based design learning could enhance the creative problem-solving of undergraduate architecture students in Thailand. 3) design and develop a mixed-reality learning environment in studio-based learning to enhance creative problem-solving for architecture. 4) define mixed-reality learning environments in studio-based learning to enhance creative problem-solving for architecture. Samples are a multistage random sampling of 655 undergraduate architecture students in Thailand. Three experts in the first phase validated the self-evaluation form. Nineteen undergraduate students …
Demographic Profile And Clinical Characteristics Of Fuchs Endothelial Corneal Dystrophy In Thai Patients: A Retrospective Cohort In A Tertiary Referral Center, Trakanta Wannapanich
Demographic Profile And Clinical Characteristics Of Fuchs Endothelial Corneal Dystrophy In Thai Patients: A Retrospective Cohort In A Tertiary Referral Center, Trakanta Wannapanich
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: This study aimed to describe the demographic profiles, clinical characteristics, and the 5-year clinical course of Fuchs endothelial corneal dystrophy (FECD) in Thai patients. Secondary objectives included identifying the risk factors associated with corneal transplantation and evaluating surgical trends, particularly the types of corneal transplantation performed. Methods: This retrospective cohort study analyzed clinical data from 900 Thai patients (1,743 eyes) diagnosed with FECD. Demographic information, clinical characteristics, and follow-up data over five years were collected. Statistical methods, including logistic regression, were used to identify factors predicting corneal transplantation. Results: The mean age of the cohort was 63.84 ± 11.89 …
Epigenetic Regulation Of Cancer Testis Antigens In Hepatocellular Carcinoma, Rinrada Klankajorn
Epigenetic Regulation Of Cancer Testis Antigens In Hepatocellular Carcinoma, Rinrada Klankajorn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Hepatocellular carcinoma (HCC) represents one of the most common causes of cancer-related death worldwide, with few available treatment options. Cancer-testis antigens (CTAs), notably from the MAGE gene family, have opened new possibilities for improving immunotherapy in HCC due to their tumor-specific expression and high immunogenicity. However, the mechanisms regulating MAGE gene expression are largely unknown. This study explored mechanisms controlling the expression of MAGE-A3 and MAGE-C2. We utilized HCC organoid cultures derived from patient HCC tissues known to represent cancer epigenetic status more accurately than cell lines to study the MAGE gene family expression patterns and promoter methylation patterns. Our …
Acute Toxicity Study Of Canine Mesenchymal Stem Cell (Msc)-Derived Exosome Preparation For Drug Registration, Anatcha Thongsit
Acute Toxicity Study Of Canine Mesenchymal Stem Cell (Msc)-Derived Exosome Preparation For Drug Registration, Anatcha Thongsit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Exosomes, spherical vesicles secreted by cells containing diverse biomolecules, are gaining attention in veterinary medicine. Mesenchymal stem cell (MSC)-derived exosomes show promise for treating animal diseases. However, their safety profile, particularly the acute toxicity of canine MSC-derived exosomes, has yet to be adequately explored. This study evaluates the acute toxicity of canine MSC-derived exosomes on rat systemic health, adhering to ISO 10993-11 guidelines for systemic toxicity testing to support veterinary drug registration and development. The study tested acute toxicity in five female Sprague Dawley rats by administering exosomes at a concentration of 1×109 particles/mL via intravenous injection into the tail …
Comparative Electron Microscopy Analysis Of Internal Limiting Membrane And Epiretinal Membrane Ultrastructure From Pars Plana Vitrectomy, Thananop Pothikamjorn
Comparative Electron Microscopy Analysis Of Internal Limiting Membrane And Epiretinal Membrane Ultrastructure From Pars Plana Vitrectomy, Thananop Pothikamjorn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Histopathological difference and biomarkers related between the internal limiting membrane (ILM) in eyes with and without epiretinal membrane (ERM) remains unknown. This study characterizes the ultrastructural and histopathological features of the internal limiting membrane (ILM) in eyes with and without epiretinal membrane (ERM) undergoing vitrectomy.Methods: ILM specimens were intraoperatively collected and analyzed using light microscopy (LM) to assess nuclei counts, and transmission electron microscopy (TEM) to evaluate vacuolization, specimen consistency, cell types and other ultrastructural features. One eye per participant was included. Histopathological features were compared between ILM with and without ERM, as well as between idiopathic and secondary …
Incidence, Risk Factors, And Outcome Of Anti-Tuberculosis Drug-Induced Hepatotoxicity In People With And Without Hiv In Thailand And The Philippines, Ryan Christopher Atuel
Incidence, Risk Factors, And Outcome Of Anti-Tuberculosis Drug-Induced Hepatotoxicity In People With And Without Hiv In Thailand And The Philippines, Ryan Christopher Atuel
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Anti-tuberculosis drug-induced hepatotoxicity (DIH) is a common complication among people living with HIV (PLWH), potentially leading to treatment interruptions. Objective: To determine the incidence of DIH and identify risk factors in Thai and Filipino PLWH on tuberculosis (TB) treatment, compared with those with TB mono-infection. Materials and Methods: We conducted a cohort study of Thai and Filipino adults with active TB using retrospective data from Thailand (2000–2024) and prospective data from the Philippines (2024). Eligible participants had AST/ALT results at TB treatment initiation and follow-up. DIH was defined as AST or ALT ≥3 times the upper limit of normal. …
Expression Optimization And Characterization Of Plant-Produced Human Interleukin-15, Chalatorn Charnsatabut
Expression Optimization And Characterization Of Plant-Produced Human Interleukin-15, Chalatorn Charnsatabut
Chulalongkorn University Theses and Dissertations (Chula ETD)
Human interleukin-15 (hIL-15) is a cytokine that plays a crucial role in immune responses like T cell proliferation, activation, and prolongation of natural killer (NK) cells. This cytokine also impacts the cell proliferation of human adult low calcium temperature (HaCaT) keratinocytes which can lead to the wound-healing effect. This study aimed to optimize the expression and characterize the recombinant hIL-15 in Nicotiana benthamiana with the Agrobacterium-mediated transient expression system. The hIL-15 gene was fused with the Fc domain from the IgG1 antibody for purification. The expression cassette was optimized for sub-cellular targeting and agroinfiltration. The transiently expressed hIL-15-Fc was purified …
Molecular Mechanism Of Lusianthridin On Platelet Aggregation Inhibition And Endothelial Cell Protection, Fozia -
Chulalongkorn University Theses and Dissertations (Chula ETD)
Lusianthridin (LST), a bioactive compound isolated from Dendrobium venustum, exhibits notable vasoprotective properties. This study aimed to elucidate the underlying molecular mechanisms of LST by evaluating its effects on platelet function and endothelial cell activation in vitro. In human platelets, LST significantly inhibited collagen-induced aggregation, an effect associated with elevated phosphorylation of vasodilator-stimulated phosphoprotein (VASP) and suppression of Akt phosphorylation. In EA.hy926 endothelial cells, LST attenuated tumor necrosis factor-alpha (TNF-α)-induced endothelial dysfunction by reducing nitric oxide (NO) production and suppressing the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6) and interleukin-1β (IL-1β). Mechanistic investigations revealed that LST inhibited key inflammatory signaling …
Predicting The Eq-5d-5l Utility Scores From The Impact Of Vision Impairment (Ivi) Questionnaire In Thai Patients, Emilia Audrey Tunmas Pasenggong
Predicting The Eq-5d-5l Utility Scores From The Impact Of Vision Impairment (Ivi) Questionnaire In Thai Patients, Emilia Audrey Tunmas Pasenggong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives : (1) This study aims to predict the EQ-5D-5L utility scores from the impact of vision impairment (IVI) questionnaire in Thai patients using mapping techniques. (2) To investigate the association between sociodemographic and clinical variables with the EQ-5D-5L index scores. Methods : This is a secondary data analysis. A total of 499 patients with multiple levels of visual impairment were recruited from King Chulalongkorn Memorial Hospital Thailand between February and July 2022. Ordinary least square (OLS), Tobit, Censored least absolute deviation (CLAD), and Adjusted limited dependent variable mixture model (ALDVMM) regression models were used to map the IVI questionnaire …
Development Of Granule Product Containing Curcuminoid Extract And Hyaluronic Acid Derivative For Oral Administration, Natkhanang Boonpetcharat
Development Of Granule Product Containing Curcuminoid Extract And Hyaluronic Acid Derivative For Oral Administration, Natkhanang Boonpetcharat
Chulalongkorn University Theses and Dissertations (Chula ETD)
Curcumin is widely recognized for its various pharmacological properties, including antioxidant, anti-inflammatory, and anti-tumor activities. Nevertheless, the development of curcumin as a therapeutic agent is impeded by its limited oral bioavailability, which stems from its chemical instability, poor aqueous solubility, and rapid degradation. This study aimed to develop granule formulations incorporating hyaluronic acid graft poly(N-isopropylacrylamide) or HA-g-pNIPAM to enhance dissolution and protect curcumin from degradation. Three formulations were developed: F10 (HA-g-pNIPAM physically mixed with curcumin), F10 Encap (curcumin encapsulated within HA-g-pNIPAM), and F11 (curcumin granules without HA-g-pNIPAM). The stability results showed that F10 Encap effectively maintained curcumin content throughout the …
The Effect Of Stilbene Derivatives On Modulation Of P-Gp Efflux Transporter, Shahnila Mukhtar
The Effect Of Stilbene Derivatives On Modulation Of P-Gp Efflux Transporter, Shahnila Mukhtar
Chulalongkorn University Theses and Dissertations (Chula ETD)
Drug efflux by transporters of the ATP-binding cassette (ABC) family such as P-glycoprotein is the earliest and most well-studied multidrug resistant (MDR) mechanism. Overexpression of ATP-binding cassette transporters can decrease the effectiveness of chemotherapy by pumping anti-cancer drugs out of cancer cells. This study was to predict the best-fit of certain stilbenoids isolated from Thai orchids as a specific P-gp moderator, using the molecular docking approach to compare and specify the binding interaction between each stilbenoids and the P-gp binding domains. Furthermore, the in vitro substrate uptake assays of eight stilbenoids with phenanthrene core structure were conducted for assessing their …
Factors Contributing To Self-Medication And Quality Of Life Of Myanmar Immigrants In The Covid-19 Pandemic Situation, Su Myat Thin
Factors Contributing To Self-Medication And Quality Of Life Of Myanmar Immigrants In The Covid-19 Pandemic Situation, Su Myat Thin
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Due to numerous difficulties in accessing necessary healthcare and standard medication, immigrants might be more likely to rely on self-medication to solve health problems they suffered. Although it might provide immediate relief, it could also bring some risks such as adverse drug reactions, antimicrobial resistance progression, drug side effects, and toxicity. This study aimed to identify the healthcare service accessibility and self-medication of immigrants in Thailand for COVID-19. Additionally, this study also aimed to evaluate the effect of immigrants’ COVID-19 perception on their self-medication uses and quality of life. This study had two phases in which the first phase …
The Effect Of Artogomezianone On Apoptosis Induction In Non-Small-Cell Lung Cancer, Worawich Somboonvoravong
The Effect Of Artogomezianone On Apoptosis Induction In Non-Small-Cell Lung Cancer, Worawich Somboonvoravong
Chulalongkorn University Theses and Dissertations (Chula ETD)
NSCLC severity is driven by dysregulation of the EGFR/PI3K/Akt pathway, promoting tumor growth and drug resistance. Hyperactive EGFR/PI3K/Akt signaling results in aggressive tumors and poor outcomes, further worsened by resistance to EGFR inhibitors. Targeting this pathway could inhibit tumor growth and resistance. artogomezianone, a compound derived from Artocarpus gomezianus, has shown considerable anti-cancer efficacy, mainly by inducing apoptosis and decreasing the proliferation of several cancers. This study investigated artogomezianone’s effects on the EGFR/PI3K/Akt pathway. Cytotoxic and apoptotic effects were assessed using MTT assay and Hoechst 33342/PI double staining, with confirmation by Western blot analysis. Protein levels and binding affinity were …
Effect Of An Mrna Vaccine On Liver-Associated Macrophages And The Immunogenicity Of Ag85b-Mrna Vaccine Against Tuberculosis, Chitsuda Pongma
Effect Of An Mrna Vaccine On Liver-Associated Macrophages And The Immunogenicity Of Ag85b-Mrna Vaccine Against Tuberculosis, Chitsuda Pongma
Chulalongkorn University Theses and Dissertations (Chula ETD)
A new vaccine technology based on the delivery of mRNA has gained widespread acceptance due to the COVID-19 pandemic. The delivery of mRNA formulated with lipid nanoparticles (LNPs) elicits a robust immune response, activating both humoral and cell-mediated response. Depending on the LNP formula, mRNA encoding proteins can be detected in the liver upon intramuscular (IM) administration in mice. Thus, an mRNA vaccine present novel platform for new vaccines for infection diseases, including tuberculosis (TB). This study proposed two major goals to investigate the impact of an mRNA vaccine on innate immune cells in the liver and the use of …
Roles Of Reactants And Catalysts For Suzuki C-C Cross-Coupling Reaction Using Molecular Volcano Plots And Big-Data Analysis, Kwanchanok Kaewkwan
Roles Of Reactants And Catalysts For Suzuki C-C Cross-Coupling Reaction Using Molecular Volcano Plots And Big-Data Analysis, Kwanchanok Kaewkwan
Chulalongkorn University Theses and Dissertations (Chula ETD)
The Suzuki carbon–carbon cross-coupling reaction is a well-known method for forming carbon–carbon bonds, catalyzed by transition metal complexes. Molecular volcano plots have been used to predict promising catalysts. While previous studies focused mainly on thermodynamic insight, with limited focus on kinetics, this work examines the influence of catalysts and reactants on catalytic activity by incorporating kinetic energy profiles. DFT calculations were performed to evaluate free energies of catalytic states, establish linear scaling relationships, and construct volcano plots. This study employed nickel and palladium complexes with five different ligands as catalysts, reacting with twenty-five substrates. Results show that catalysts have a …
Immune Signaling And Pathogenesis Of Enterocytozoon Hepatopenaei Infection In Pacific White Shrimp Litopenaeus Vannamei, Nutthapon Sangklai
Immune Signaling And Pathogenesis Of Enterocytozoon Hepatopenaei Infection In Pacific White Shrimp Litopenaeus Vannamei, Nutthapon Sangklai
Chulalongkorn University Theses and Dissertations (Chula ETD)
Enterocytozoon hepatopenaei (EHP) is an intracellular microsporidian parasite causing hepatopancreatic microsporidiosis (HPM), a disease that impairs the digestion and nutrients absorption of shrimp and leads to growth retardation and size variation. Our studies aim to comprehensively investigate the host’s immune responses to the EHP infection and the pathogenesis of the parasite. It was found that genes in Toll and JAK/STAT pathways, as well as antimicrobial peptides, were highly upregulated upon the EHP infection. Importantly, suppression of the JAK/STAT pathways resulted in a significant reduction of the c-type lysozyme (LvLyz-c) expression and the elevation of EHP copy numbers. These indicate a …
Development Of Biosensors For Detection Of Human Papillomavirus Type 16 Dna, Panon Tungkunaruk
Development Of Biosensors For Detection Of Human Papillomavirus Type 16 Dna, Panon Tungkunaruk
Chulalongkorn University Theses and Dissertations (Chula ETD)
This dissertation aims to develop two unconventional methods for the detection of a high-risk, cancer-causing human papillomavirus type 16 (HPV16) on miniaturized platforms for point-of-care testing (POCT). The first part focuses on a direct detection of HPV16 double-stranded DNA (dsDNA) using the non-self-pairing pyrrolidinyl peptide nucleic acid (acpcPNA) pair on a paper-based substrate coupled with fluorescence and electrochemical dual detections using a DNA-binding dye in a single device. The acpcPNA pair can perform double duplex invasion into dsDNA by hybridizing with each strand of DNA in the same region without the requirement of denaturing dsDNA to single-stranded DNA (ssDNA) before …
Health Impact Assessment From Fine Particulate Matter Pm10 And Pm2.5 In Thailand, Phawichsak Prapassornpitaya
Health Impact Assessment From Fine Particulate Matter Pm10 And Pm2.5 In Thailand, Phawichsak Prapassornpitaya
Chulalongkorn University Theses and Dissertations (Chula ETD)
The rapid urbanization and industrial sector have caused significant air quality problems. In particular, the concentration of fine particulate matter (PM10,PM2.5) is an assessment of the impact of fine particulate matter. Health The main objective of this study was to compare PM10 and PM2.5 levels and temporal trends from 2015 to 2019, and to develop a model to forecast particulate matter concentrations using multiple linear regression analysis. Multiple Linear Regression (MLR) to assess the association between particulate matter exposure and daily hospital visit for respiratory diseases. (ICD-10: J00-J99) and identify vulnerable populations. In the research, PM10 and PM2.5 air quality …
Molecular Dynamics Investigation Of Fluorine-Free Electrolytes For Sodium-Ion Batteries, Phitchapa Ausamanwet Zijdemans
Molecular Dynamics Investigation Of Fluorine-Free Electrolytes For Sodium-Ion Batteries, Phitchapa Ausamanwet Zijdemans
Chulalongkorn University Theses and Dissertations (Chula ETD)
Sodium-ion batteries (SIBs) are a promising alternative to lithium-ion batteries due to the abundance and low cost of sodium. However, conventional SIB electrolytes often rely on fluorine-based salts, contributing to the formation of persistent and environmentally harmful per- and polyfluoroalkyl substances (PFAs). This study employs molecular dynamics (MD) simulations to investigates the properties of fluorine-free electrolytes for SIBs, focusing on the solvation structure and dynamics of sodium ions (Na+) in bulk electrolytes and at the inner solid electrolyte interphase (SEI) for SIBs. Sodium perchlorate (NaClO4) at a concentration of 1 M was examined in glyme solvents with varying chain lengths, …
Development Of Electrochemical Sensor Based On Molecularly Imprinted Polymer For Determination Of Roxarsone, Pitranan Kunthanasap
Development Of Electrochemical Sensor Based On Molecularly Imprinted Polymer For Determination Of Roxarsone, Pitranan Kunthanasap
Chulalongkorn University Theses and Dissertations (Chula ETD)
Roxarsone (ROX), a growth enhancer in poultry and swine, has the potential to improve weight gain and prevent coccidiosis. Excessive use of ROX may lead to its accumulation in animal tissues, potentially contaminating food products and posing health risks to humans through consumption. This research aims to develop an electrochemical sensor based on a magnetic screen-printed graphene electrode (mSPGE) modified with a highly selective molecularly imprinted polymer (MIP) for the determination of ROX with enhanced sensitivity and selectivity. Typically, an applied magnetic field at the mSPGE could accelerate mass transport at the electrode surface through the magnetohydrodynamic (MHD) effect, leading …
Flow Accelerated Corrosion In Economizer Tubes Of A Heat Recovery Steam Generator Using Computational Fluid Dynamics, Phuris Khunphakdee
Flow Accelerated Corrosion In Economizer Tubes Of A Heat Recovery Steam Generator Using Computational Fluid Dynamics, Phuris Khunphakdee
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study investigates the effects of operating and harp design parameters on flow accelerated corrosion (FAC) using CFD, based on a real case from a modern heat recovery steam generator (HRSG) where severe FAC occurred in an economizer harp after six years of service. Preliminary investigation found that contributions for this case include the construction material, which is carbon steel, the operating temperature range that close to FAC favourable temperature (150 °C), reduced water and disturbed flow geometry. Comparison of shear stress and wall thickness profiles confirmed that FAC is mass transfer dominated, driven by flow acceleration and recirculation near …
Aza-Piancatelli And Friedel-Crafts Reactions Under Microdroplet Conditions, Phanomsak Yukhet
Aza-Piancatelli And Friedel-Crafts Reactions Under Microdroplet Conditions, Phanomsak Yukhet
Chulalongkorn University Theses and Dissertations (Chula ETD)
The development of sustainable, catalyst-free synthetic methodologies represents a significant advance in modern organic chemistry, which offers environmentally benign alternatives to conventional protocols that often rely on metal catalysts or harsh reagents. This dissertation presents two complementary studies to explore and establish novel catalyst-free synthetic strategies in both microdroplet and bulk solution phases and highlight their potential applications, mechanistic features, and practical limitations. The first part of this work investigates the rearrangement of furfural with secondary amines to yield 4,5-diaminosubstituted cyclopentenones (4,5-DCPs) within the unique reaction environment of electrospray-generated charged microdroplets. The reaction is proposed to proceed via a Stenhouse …