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Development Of Parkinson’S Glove For Detection And Suppression Of Hand Tremor At Rest Among The Tremor-Dominant Parkinson’S Disease Patients With Medically Intractable Tremor., Onanong Jitkritsadakul Jan 2017

Development Of Parkinson’S Glove For Detection And Suppression Of Hand Tremor At Rest Among The Tremor-Dominant Parkinson’S Disease Patients With Medically Intractable Tremor., Onanong Jitkritsadakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this study were to determine the efficacy of an electrical muscle stimulation (EMS) as a treatment for drug resistant tremor in PD patients by identifying of the most suitable stimulation protocols for tremor reduction and to seek out for the best location for placement of the surface electrodes (phase 1) and developing the Parkinson's glove and test for its efficacy in suppression of hand tremor at rest among the tremor-dominant Parkinson's disease patients with medically intractable tremor (phase 2). From phase 1 study, 34 PD patients with classic resting tremor was recruited. The suitable stimulation protocol and …


Factors Influencing On Nursing Care Quality Perceived By Professional Nurses In Government Hospitals, Kingdom Of Cambodia, Virya Koy Jan 2017

Factors Influencing On Nursing Care Quality Perceived By Professional Nurses In Government Hospitals, Kingdom Of Cambodia, Virya Koy

Chulalongkorn University Theses and Dissertations (Chula ETD)

This descriptive cross-sectional research design for causal modeling aimed to examine factors influencing on nursing care quality in government hospitals, Cambodia. The conceptual framework were modified from the Nurse Work Environment, Nurse Staffing, and Outcome Model and empirical studies. A multi-stage sampling was used for data collection, which conducted from October 2016 to April 2017. Three hundred and seventy five RNs represented twelve tertiary general hospitals were invited for the study. All of participants completed five questionnaires, including demographic data and nurse staffing, nurse practice environment, nursing work index, Copenhagen burnout inventory, Index work satisfaction, and Cambodian nursing care quality …


Effect Of Curcumin On The Expression Of Wound Healing-Related Genes In Human Gingival Fibroblasts, Auspreeya Rujirachotiwat Jan 2017

Effect Of Curcumin On The Expression Of Wound Healing-Related Genes In Human Gingival Fibroblasts, Auspreeya Rujirachotiwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study investigated the effect of curcumin on the expression of wound healing-related genes including transforming growth factor beta 1 (TGF-β1), transforming growth factor beta receptor type I (TGFβR I), transforming growth factor beta receptor type II (TGFβR II) and vascular endothelial growth factor (VEGF) in human gingival fibroblasts. The cytotoxicity of curcumin was determined by MTT assay. Then, cells were treated with non-cytotoxic concentrations of curcumin for 24 hours and the level of gene expression was determined by quantitative polymerase chain reaction (qPCR). Curcumin at 0.1-20 µM caused no significant change in cell viability while higher concentrations of curcumin …


Factors Associated With Dental Caries Experience In Thai Preschool Children With Cerebral Palsy Attending Non-Governmental Rehabilitation Centers, Kullanant Pansrimangkorn Jan 2017

Factors Associated With Dental Caries Experience In Thai Preschool Children With Cerebral Palsy Attending Non-Governmental Rehabilitation Centers, Kullanant Pansrimangkorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: To investigate factors associated with dental caries experience in preschool children with cerebral palsy attending physical therapy programs in non-governmental rehabilitation centers in Bangkok. Materials and Methods: This research is a cross sectional study of 60 children with cerebral palsy, aged 3-6 years, mean age 5.01 ± 1.23 years old. Dental caries experience was determined by dmfs index, numbers of surfaces of dental caries, extracted tooth, and filled tooth. The other variables were collected including: dental plaque index (OHI-S), type of cerebral palsy, frequency of carbohydrate intake events, dietary consistency, assisting with toothbrushing, and frequency of toothbrushing. Multiple linear …


Mechanism And Performance Of Solid Non-Particulate Soil (Waxy Solid) Removal From Fabrics, Jarussri Chanwattanakit Jan 2017

Mechanism And Performance Of Solid Non-Particulate Soil (Waxy Solid) Removal From Fabrics, Jarussri Chanwattanakit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Methyl palmitate or palmictic acid methyl ester was used as both a model solid fat and an oily soil was removed from cotton and polyester above and below the melting point. Surfactants studied were extended surfactants (C12,13-4PO-SO4Na , C12,14-10PO-2EO-SO4Na and C12,14-16PO-2EO-SO4Na), alcohol ethoxylate (EO9), sodium dodecyl sulfate (SDS), methyl ester sulfonate (MES), methyl ester ethoxylate (MEE), and mixed surfactants between extended surfactant (C12,13-4PO-SO4Na) and sodium mono- and dimethyl naphthalene sulfonate (SMDNS). Above the melting point (~30 ºC) of methyl palmitate, the maximum oily soil removal was found to correlate well with the lowest dynamic interfacial tension (IFT) with increasing washing …


Development Of Poly(Aryleneethynylene)S Synthesis And Application As Fluorescent Sensor, Nopparat Thavornsin Jan 2017

Development Of Poly(Aryleneethynylene)S Synthesis And Application As Fluorescent Sensor, Nopparat Thavornsin

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this research, we focus on preparation and sensor application of poly(aryleneethynylene)s. Our work is divided into two parts. The first study relates to the utilization of salicylaldimine-functionalized poly(m-phenyleneethynylene) as a turn-on chemosensor for ferric ion (Fe3+). The second part is the preparation of highly pure poly(aryleneethtnylene)s using Pd/CaCO3 as a heterogeneous catalyst. In the first part, a new turn-on fluorescent probe for ferric ion based on poly(m-phenyleneethynylene salicylaldimine) (PPE-IM) is developed. The preparation of PPE-IM involves post-polymerization functionalization of corresponding polymeric amine, PPE-AM, via condensation with salicylaldehyde. Degree of polymerization of both PPE-AM and PPE-IM are 17 with polydispersity …


Use Of Anionic Surfactant In Regeneration Of Spent Activated Carbon, Buch Kallapadee Jan 2017

Use Of Anionic Surfactant In Regeneration Of Spent Activated Carbon, Buch Kallapadee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Surfactant-enhanced carbon regeneration (SECR) is a regeneration process that utilizes surfactant solution to dissolve adsorbed organic from spent activated carbon. Sodium dodecyl sulfate (SDS) and methyl ester sulfonate (MES) are anionic surfactants that are used in this investigation. The study is done in 3 steps: sample characterization, regeneration and water flushing step. The proximate analysis of spent activate carbon contains 27.5% moisture, 27.2% volatile matter content, 10% total ash content. The spent activated carbon also contains 18.4% benzene. In regeneration step, the benzene removal by SDS and MES solution were compared. The effect of concentration, solution flow rate and temperature …


Conversion Of Palm Fatty Acid Distillate To Biojet Fuel Over Ni/Hy-Pditioz Core-Shell Catalyst, Chanakran Homla-Or Jan 2017

Conversion Of Palm Fatty Acid Distillate To Biojet Fuel Over Ni/Hy-Pditioz Core-Shell Catalyst, Chanakran Homla-Or

Chulalongkorn University Theses and Dissertations (Chula ETD)

Generally, jet fuel is obtained from the refining of petroleum feedstock in order to powering the aircrafts, hence the world is more confronting a problem with increasing air pollution emission. Therefore, biojet fuel is introduced as an alternative way to solve the problem. Biojet fuel can be derived from bio-based feedstock such as palm fatty acid distillate or PFAD. Which is converted via the deoxygenation reaction in order to remove oxygenated compounds, carboxylic and carbonyl groups in the fatty acid molecules then followed by hydrocracking and hydroisomerization reaction. The heterogeneous catalyst is used to convert PFAD into saturated paraffins in …


Analysis Of Biomarkers In Crude Oils, Processed Oils, And Spilled Oils, Pornpetch Hattakijvilai Jan 2017

Analysis Of Biomarkers In Crude Oils, Processed Oils, And Spilled Oils, Pornpetch Hattakijvilai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Oil spills in marine are commonly come from crude oils, fuel oils and lubricating oils by accidental leakages or purposeful discharges to the surroundings. As crude oil and fuel oil which refined from the heavy fraction of crude oil have similar physical properties especially if they were weathering, it is difficult to differentiate that the spill has the origin from crude oil or fuel oil. In this study, five crude oils, two fuel oils, one fresh and one used lube oil that are typically used in Thailand were investigated. All crude oils, fuel oils, and used lube oil were weathered …


Toxicity Of Silver, Silver-Copper And Silver-Tin Nanoparticles In Thp-1 Cell Line And Thp-1 Differentiated Macrophage Cells, Patamaporn Monprasit Jan 2017

Toxicity Of Silver, Silver-Copper And Silver-Tin Nanoparticles In Thp-1 Cell Line And Thp-1 Differentiated Macrophage Cells, Patamaporn Monprasit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Silver nanoparticles (AgNPs) and nanoparticles in the form of silver-metal alloy, such as silver-copper (AgCuNPs) and silver-tin (AgSnNPs) have been applied in various industries and medical applications. To assess effects of these nanoparticles on human immune system, this study aimed to assess toxicity of AgNPs, AgCuNPs and AgSnNPs on human monocytes, THP-1 cells, and THP-1 differentiated macrophage cells. The nanoparticles were characterized and assessed for cytotoxicity and generation of intracellular ROS. Effects of the nanoparticles on the release of cytokines (TNF-α, IL-1β and IL-8) were also assessed. The results demonstrated no significant cytotoxicity of silver and silver-metal nanoparticles at the …


Enhancing H2s Sensing Response Of Calcium Copper Titanate Thin Films By Adding Ag Compounds, Aukrit Natkaeo Jan 2017

Enhancing H2s Sensing Response Of Calcium Copper Titanate Thin Films By Adding Ag Compounds, Aukrit Natkaeo

Chulalongkorn University Theses and Dissertations (Chula ETD)

Ag-doped CaCu3Ti4O12 (CCTO) thin films with different doping concentrations were prepared by a sol-gel technique. Films were grown by depositing four layers of CCTO on alumina substrates followed by sputtering Au/Cr interdigitated electrodes to fabricate gas sensors. The films were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX) Raman spectroscopy and X-ray photoemission spectroscopy (XPS). The films have predominantly the perovskite CCTO crystal phase with very small amount of TiO2 secondary phases. In this thesis, both undoped CCTO and Ag-doped CCTO thin films were tested for selective sensing to H2S gas relative …


Subjective And Objective Outcomes On Denture Adhesive Usage Among Complete Denture Wearers, Budsara Thongyoi Jan 2017

Subjective And Objective Outcomes On Denture Adhesive Usage Among Complete Denture Wearers, Budsara Thongyoi

Chulalongkorn University Theses and Dissertations (Chula ETD)

The propose of this clinical study was to evaluate the subjective and objective assessment factors affecting decision of complete denture wearers to use or not use denture adhesive. Sixty-six fully edentulous using upper and lower conventional complete dentures (aged 53 to 83 years) were recruited in this study. (1) Condition of denture-supporting tissue (ACP classification), (2) denture quality (CU-modified kapur criteria), (3) patients' satisfaction in prostheses and (4) oral impact on daily performances (OIDP) were evaluated as baseline (T0). All participants were assigned to use denture adhesive (Polident®, Ireland) for 1 month period and made decision by themselves to continue …


The Synthesis, Modification And Application Of Silica Nanoparticles In Polymethyl Methacrylate Denture Base, Pornpot Jiangkongkho Jan 2017

The Synthesis, Modification And Application Of Silica Nanoparticles In Polymethyl Methacrylate Denture Base, Pornpot Jiangkongkho

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to investigate amount of γ-methacryloxypropyltrimethoxysilane (MPS) silanized on experimental nanosilica particles (NPs), amount of NPs and amount of MPS silanized NP on flexural strength (FS), flexural modulus (FM), and fracture toughness (FT) of NP reinforced polymethymethacrylate (PMMA). The chemisorbed amount of MPS was determined using elemental analysis. Six groups (n=8) were prepared with chemisorbed amount and mixed with PMMA-monomer to make 0.25, 0.5, 1, 5, 10 and 15% (w/w) of NP reinforced PMMA. PMMA without NP served as control. Seven groups (n=8) were prepared with 1% of NPs silanized with 0, 0.061, 0.123, 0.246, 0.493, 0.987, and …


Factors Influencing Quality Of Life Among Elderly Population With Type 2 Diabetes Mellitus: A Clinic Based Cross Sectional Study In Kathmandu Valley, Kriti Adhikari Jan 2017

Factors Influencing Quality Of Life Among Elderly Population With Type 2 Diabetes Mellitus: A Clinic Based Cross Sectional Study In Kathmandu Valley, Kriti Adhikari

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Diabetes is one of the four priority non communicable disease whose worldwide prevalence is at an increasing trend and is accompanied by deterioration of quality of life especially that of the elderly population. Several factors contribute to influence quality of life among the elderly; therefore, this study aims to identify the factors that influence quality of life among elderly population of Kathmandu valley, Nepal Methods: A cross sectional survey was conducted among random sample of 310 elderly diabetic patients visiting diabetic clinic of Kathmandu Diabetes and Thyroid center in Kathmandu valley, Nepal. Translated Nepali version of WHOQOL BREF was …


การพัฒนาโมเดลวินิจฉัยความเข้าใจในการอ่านภาษาไทยของนักเรียนชั้นประถมศึกษาปีที่ 6 : การประยุกต์ใช้โมเดลฟิวชัน, ธนิยา เยาดำ Jan 2017

การพัฒนาโมเดลวินิจฉัยความเข้าใจในการอ่านภาษาไทยของนักเรียนชั้นประถมศึกษาปีที่ 6 : การประยุกต์ใช้โมเดลฟิวชัน, ธนิยา เยาดำ

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อ 1) พัฒนาทักษะความเข้าใจในการอ่านภาษาไทยของนักเรียนชั้นประถมศึกษาปีที่ 6 2) พัฒนาแบบทดสอบความเข้าใจในการอ่านภาษาไทยของนักเรียนชั้นประถมศึกษาปีที่ 6 3) ตรวจสอบคุณภาพแบบทดสอบความเข้าใจในการอ่านภาษาไทยของนักเรียนชั้นประถมศึกษาปีที่ 6 และ 4) วินิจฉัยความเข้าใจในการอ่านภาษาไทยของนักเรียนชั้นประถมศึกษาปีที่ 6 โดยใช้โมเดลฟิวชัน กลุ่มตัวอย่าง ประกอบด้วย (1) ผู้เชี่ยวชาญ 17 คน เพื่อพัฒนาทักษะความเข้าใจในการอ่าน (2) นักเรียนชั้นประถมศึกษาปีที่ 6 จำนวน 818 คน เพื่อวินิจฉัยความเข้าใจในการอ่าน เครื่องมือมี 3 ฉบับ คือ แบบสอบถาม 2 ฉบับ สำหรับผู้เชี่ยวชาญเป็นสอบถามเกี่ยวกับทักษะความเข้าใจในการอ่าน โดยชุดที่ 1 เป็นแบบสอบถามปลายเปิด ชุดที่ 2 เป็นแบบสอบถามปลายปิด และแบบทดสอบความเข้าใจในการอ่านภาษาไทย 1 ฉบับ สำหรับนักเรียน วิเคราะห์ข้อมูลโดยใช้สถิติเชิงบรรยาย ได้แก่ ร้อยละ ค่าเฉลี่ย และส่วนเบี่ยงเบนมาตรฐาน วิเคราะห์ทักษะความเข้าใจในการอ่านภาษาไทย หาฉันทามติด้วยค่ามัธยฐาน ผลต่างของมัธยฐานกับฐานนิยม และพิสัยระหว่างควอไทล์ วิเคราะห์โมเดลวินิจฉัยความเข้าใจในการอ่านโดยใช้โมเดลฟิวชัน ผลการวิจัยพบว่า ความเข้าใจในการอ่านภาษาไทยมี 7 ทักษะ ดังนี้ 1) การบอกความหมายของคำศัพท์โดยไม่อาศัยบริบท 2) การบอกความหมายของคำศัพท์โดยอาศัยบริบท 3) การจับใจความรองโดยไม่อาศัยบริบท 4) การจับใจความรองโดยอาศัยบริบท 5) การจับใจความหลักโดยไม่อาศัยบริบท 6) การจับใจความหลักโดยอาศัยบริบท และ 7) การตีความ ทักษะความเข้าใจในการอ่านภาษาไทย 7 ทักษะ ผู้เชี่ยวชาญมีความคิดเห็นเป็นฉันทามติในระดับมากที่สุด (Md=5.00, |Md-Mo|=0, IR=0) แบบทดสอบความเข้าใจในการอ่านภาษาไทยของนักเรียนชั้นประถมศึกษาปีที่ 6 ที่ครอบคลุมทั้ง 7 ทักษะ มีจำนวนข้อสอบ 23 ข้อ เป็นแบบทดสอบแบบอิงสถานการณ์ รูปแบบข้อสอบเป็นแบบเลือกตอบ 4 ตัวเลือก คุณภาพของข้อสอบจากการวิเคราะห์ด้วยโปรแกรม MULTILOG มีค่าความยากง่าย (b) …


Effects Of Ratio Of Oxygen Partial Pressure To Propane Partial Pressure And Temperature On Non-Faradaic Electrochemical Modification Of Catalytic Activity (Nemca) Of Propane Oxidation On Pt-Ysz, Sareerat Thongsrigate Jan 2017

Effects Of Ratio Of Oxygen Partial Pressure To Propane Partial Pressure And Temperature On Non-Faradaic Electrochemical Modification Of Catalytic Activity (Nemca) Of Propane Oxidation On Pt-Ysz, Sareerat Thongsrigate

Chulalongkorn University Theses and Dissertations (Chula ETD)

The effects of electrochemical promotion of catalysis (EPOC) or non-faradaic electrochemical modification of catalytic activity (NEMCA) of sputtered-Pt catalyst on Y2O3-stabilized-ZrO2 (YSZ) disk, an O2- conductor, were studied with the catalytic reaction of propane oxidation, which was chosen to model the combustion of residual hydrocarbons in catalytic converters. In electrochemical promotion, the catalyst was electrochemically promoted by applying electric current or potential between the Pt and Au electrodes of YSZ disk. Catalytic performances were studied under the ratio of oxygen partial pressure to propane partial pressure difference of 1 to 5 and partial pressure of propane was 1 kPa, in …


Chemical Constituents From The Roots Of Calophyllum Calaba L., Fuengfa Laopian Jan 2017

Chemical Constituents From The Roots Of Calophyllum Calaba L., Fuengfa Laopian

Chulalongkorn University Theses and Dissertations (Chula ETD)

Phytochemical investigation of the CH2Cl2 extract from the roots of C. calaba let to the isolation of three new xanthone derivatives, namely calaxanthones A-C (1-3), along with twenty nine known xanthones (4-32). The structures of all isolated compounds were fully characterized using spectroscopic data (1D and 2D NMR) as well as comparison with the previous literature data. Moreover, all isolated compounds were assessed for their in vitro cytotoxicity against the KB, HeLa S-3, HT29, MCF-7 and HepG2 human cancer cell lines. The tested compounds mostly showed moderate to inactive against these five cell lines, except compounds 3 showed potent cytotoxicity …


Optimum Patch Design For Repairing Cracked Steel Plates Using Genetic Algorithm, Bach Kim Do Jan 2017

Optimum Patch Design For Repairing Cracked Steel Plates Using Genetic Algorithm, Bach Kim Do

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research presents a design optimization process that combines the finite element (FE) method, genetic programming (GP), and optimization solvers, i.e., genetic algorithm (GA) and nonlinear programming, for double-sided fiber-reinforced polymer (FRP) patches used to repair center-cracked steel plates under tension fatigue. An optimization statement is to minimize the patch volume and reduce the stress intensity factor (SIF) range at crack tips below the fatigue threshold range. A detailed three-dimensional (3D) FE model of patch-repaired cracked plates is developed to compute SIF. A total of 864 FE models of patch-repaired cracked plates with different combinations of design parameters are then …


In Silico Screening Of Chalcones Against Epstein-Barr Nuclear Antigen 1 Protein In Epstein-Barr Virus (Ebv), Nitchakan Darai Jan 2017

In Silico Screening Of Chalcones Against Epstein-Barr Nuclear Antigen 1 Protein In Epstein-Barr Virus (Ebv), Nitchakan Darai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Epstein-Barr Nuclear Antigen 1 (EBNA1), a crucial protein encoded by the Epstein-Barr virus (EBV), plays an important role in the replication and transcriptional regulator of EBV virus latent gene expression. Therefore, it is associated with several diseases especially human malignancies. The previous studies have demonstrated that chalcone derivatives can potentially inhibit the EBV virus. In this study, a series of designed chalcones were in silico screened toward EBNA1 using molecular docking. The docking results show that the interaction energies of 3a, 3b, 3d, 4g and 4h are better than those of the known anti-EBV agents, 1335528, 2122620 and 4-hydroxyderricin. The …


Synthesis And Characterization Of Cross-Linked Polyimide Film Using Tolylene Diisocyanate, Sirichai Reeyakad Jan 2017

Synthesis And Characterization Of Cross-Linked Polyimide Film Using Tolylene Diisocyanate, Sirichai Reeyakad

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cross-linked polyimide films were synthesized by the reaction between diisocyanate groups and hydroxyl functional groups in polyimide structure, which was confirmed by IR. During the thermal treatment of the cross-linked polyimide, the thermal labile component (CO₂) in the urethane segments was decomposed which might generate pores in the film. The presence of the pores was confirmed from the dielectric constant of the film. The dielectric constant of the films decreased with the increase of TDI loading. By comparing the properties of the films, the PI50-C1.0 exhibited optimum mechanical and good dielectric properties. The cross-linked structure was also confirmed by DMA. …


Role Of Assurance On The Enhancement Of Value-Relevance Of Corporate Social Responsibility Disclosure, Pimolwan Chayapornkul Jan 2017

Role Of Assurance On The Enhancement Of Value-Relevance Of Corporate Social Responsibility Disclosure, Pimolwan Chayapornkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Investors have become increasingly aware that annual financial reporting alone cannot provide all salient information about a firm. The non-financial information such as CSR information is also important and useful. However, the disclosure of non-financial information, especially the separate CSR report, is voluntary. In addition, the assurance for CSR reporting is also currently the firm's voluntary. Therefore, this research aims to investigate whether the disclosure of CSR represents the value-relevant information for investors and to investigate whether the assurance of CSR disclosure also represents the value-relevant information. Unlike prior studies which focused on the availability of assurance statement, this research …


Effects And Mechanisms Of Porcine Reproductive And Respiratory Syndrome Virus (Prrsv) Type 1 And Type 2 On The Permeability And Viability Of Porcine Endometrial Epithelial Cells, Dran Rukarcheep Jan 2017

Effects And Mechanisms Of Porcine Reproductive And Respiratory Syndrome Virus (Prrsv) Type 1 And Type 2 On The Permeability And Viability Of Porcine Endometrial Epithelial Cells, Dran Rukarcheep

Chulalongkorn University Theses and Dissertations (Chula ETD)

Both PRRSV types 1 and 2 revealed the sign of reproductive disorders associated with a lesion at implantation sites. Impairment of maternal glandular endometrium cell integrity and function by PRRSV infection may impact a proper nourishing fetus. This research was aimed to examine the effects of PRRSV type 1 and type 2 directly on the viability and barrier function of the endometrium using porcine glandular endometrial epithelial cell culture (PEG). The comparison of the route and the strain of PRRSV infection coinciding with their virulent in reproductive epithelia were considered. PEG cells isolated from the 4-6 months old PRRSV-free-herd gilts …


Potentials Of Ivabradine To Improve Cardiac Function In Dogs With Naturally Occurring, Asymptomatic Degenerative Mitral Valve Disease, Prapawadee Pirintr Jan 2017

Potentials Of Ivabradine To Improve Cardiac Function In Dogs With Naturally Occurring, Asymptomatic Degenerative Mitral Valve Disease, Prapawadee Pirintr

Chulalongkorn University Theses and Dissertations (Chula ETD)

The main hypothesis of the present study is that ivabradine (1.0 mg/kg, orally, twice daily) can reduce heart rate (HR), myocardial oxygen consumption (MVO2) and improve cardiac function in dogs with degenerative mitral valve disease (DMVD) partly due to a reduction of cardiomyocyte apoptosis. In order to test the hypothesis, this study was divided into three parts. The first part aimed to determine the appropriate single oral dose of ivabradine for reduction of HR and MVO2 as assessed by rate-pressure product (RPP= HR x systolic blood pressure). Once the appropriate dose was achieved, the second part was conducted to investigate …


The Joint Effects Of Management Incentives And Perceived Locus Of Causality On Management Earnings Forecast Disclosures, Kanjana Phonsumlissakul Jan 2017

The Joint Effects Of Management Incentives And Perceived Locus Of Causality On Management Earnings Forecast Disclosures, Kanjana Phonsumlissakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study investigates the effect of management incentives (directive and transparency) and locus of causality (internal and external) on the willingness of managers to disclose management earnings forecast reports and the accuracy of management's earnings forecast information. The experimental findings show that managers with directive incentives are less likely to disclose the earnings forecast and provide less accurate information to market participants than managers with transparency incentives, for both point and range forecast forms. In addition, locus of causality contributes to the accuracy of management earnings forecast information when the forecasts suggest underperformance, but the findings reveal no significant differences …


Role Of Assurance On The Enhancement Of Value-Relevance Of Corporate Social Responsibility Disclosure, Pimolwan Chayapornkul Jan 2017

Role Of Assurance On The Enhancement Of Value-Relevance Of Corporate Social Responsibility Disclosure, Pimolwan Chayapornkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Investors have become increasingly aware that annual financial reporting alone cannot provide all salient information about a firm. The non-financial information such as CSR information is also important and useful. However, the disclosure of non-financial information, especially the separate CSR report, is voluntary. In addition, the assurance for CSR reporting is also currently the firm's voluntary. Therefore, this research aims to investigate whether the disclosure of CSR represents the value-relevant information for investors and to investigate whether the assurance of CSR disclosure also represents the value-relevant information. Unlike prior studies which focused on the availability of assurance statement, this research …


Potentials Of Ivabradine To Improve Cardiac Function In Dogs With Naturally Occurring, Asymptomatic Degenerative Mitral Valve Disease, Prapawadee Pirintr Jan 2017

Potentials Of Ivabradine To Improve Cardiac Function In Dogs With Naturally Occurring, Asymptomatic Degenerative Mitral Valve Disease, Prapawadee Pirintr

Chulalongkorn University Theses and Dissertations (Chula ETD)

The main hypothesis of the present study is that ivabradine (1.0 mg/kg, orally, twice daily) can reduce heart rate (HR), myocardial oxygen consumption (MVO2) and improve cardiac function in dogs with degenerative mitral valve disease (DMVD) partly due to a reduction of cardiomyocyte apoptosis. In order to test the hypothesis, this study was divided into three parts. The first part aimed to determine the appropriate single oral dose of ivabradine for reduction of HR and MVO2 as assessed by rate-pressure product (RPP= HR x systolic blood pressure). Once the appropriate dose was achieved, the second part was conducted to investigate …


Effects Of Short-Term Growth Hormone Administration On Plasma Leptin Levels In Normal And Diet-Induced Obesity Rats, Sutharinee Likitnukul Jan 2017

Effects Of Short-Term Growth Hormone Administration On Plasma Leptin Levels In Normal And Diet-Induced Obesity Rats, Sutharinee Likitnukul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Obesity has related to the alteration of hormonal profiles, i.e. growth hormone (GH), insulin and leptin. Because of the pleiotropic mechanisms of GH, it plays important roles both in the pathophysiological mechanisms and the therapeutic hormonal supplementation, which probably affected plasma leptin. The present research aimed firstly to demonstrate the effect of short-term GH administration on plasma leptin in 3 conditions; basal, meal-induced and fasting condition, from the rats with different adipose tissue mass. Secondly, to investigate short-term effect of GH on insulin sensitivity and body adiposity in control, diet resistant (DR) and diet-induced obesity (DIO) rats. In this regard, …


The Protective Effect Of Hydroxyxanthone On The Leakiness Of Intestinal Epithelia By The Proinflammatory Cytokine Related To Bacterial Endotoxin, Wannaporn Chayalak Jan 2017

The Protective Effect Of Hydroxyxanthone On The Leakiness Of Intestinal Epithelia By The Proinflammatory Cytokine Related To Bacterial Endotoxin, Wannaporn Chayalak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Leaky gut characterized as decreased transepithelial electrical resistance and increased paracellular permeability to macromolecules is associated with several fatal diseases including sepsis. Pro-inflammatory cytokine IL-1β is a critical mediator of underlying mechanism through activation of myosin light chain kinase pathway. Blocking the inducible phosphorylated myosin light chain (p-MLC) indicates the successful treatment. Xanthones predominantly found in mangosteen (Garcinia mangostana) has been indicated as a potent anti-inflammatory action. Hydroxyxanthones (HDX), the major natural xanthones, have been recently synthesized in various forms. This study aimed to examine and screen the action of various forms of synthetic HDXs, in preventing the increased paracellular …


Pulmonary Lesion Texture Classification From Endobronchialultrasonogram Using Texture Analysis, Banphatree Khomkham Jan 2017

Pulmonary Lesion Texture Classification From Endobronchialultrasonogram Using Texture Analysis, Banphatree Khomkham

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research aims to develop a method to help distinguish the appearance of pulmonary lesions from a high-frequency sound (Endobronchial Ultrasound—EBUS) image. According to medical information, the appearance of smooth or rough texture of a lesion can significantly indicate that it is malignant or benign. In this study, the features that are used in the classification are divided into 3 groups: group 1 consists of 22 standard features, group 2 consists of the proposed features extracted from the weighted sum of the upper and lower GLCM which consists 12 features, and group 3 is the combination of group 1 and …


Mathematical Models For Treatment Time Of Pathogenic Infection In Blood After Antibiotics Administration, Panit Suavansri Jan 2017

Mathematical Models For Treatment Time Of Pathogenic Infection In Blood After Antibiotics Administration, Panit Suavansri

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective in this thesis is to create a mathematical model to predict the period of time needed to clear out the pathogens from the bloodstream after the patient receives certain antibiotics. The result will lead to the time where the drug administration can be terminated. This research is to compute the densities of bacteria and malaria in bloodstream at any given time and to compare this level with the actual results of the patient's blood sampling, which was sent to the laboratory for investigation. The laboratory process of the blood sampling will usually take more than 2-3 days to …