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Deep Reinforcement Learning For Electricity Energy Trading On Non-Sharing Information Scenario, Nat Uthayansuthi
Deep Reinforcement Learning For Electricity Energy Trading On Non-Sharing Information Scenario, Nat Uthayansuthi
Chulalongkorn University Theses and Dissertations (Chula ETD)
In this research, we explore an optimized model for peer-to-peer (P2P) energy trading within microgrids that addresses the gap in previous research, which often assumed mandatory sharing of private information among prosumers. Our model-based multi-agent deep reinforcement learning framework includes several key components: an LSTM for the policy model, ; the Temporal Fusion Transformer (TFT) for predicting 24h-ahead net load consumption, adept at handling multivariate time series data; the inclusion of the Global Horizontal Index (GHI) to account for solar irradiance to the model; and a clustering technique to segment the dataset of 300 households from the Ausgrid dataset in …
Multi-Material Proportional Topology Optimization Using Adaptive Quadtree Sbfe Framework, Natchanon Chantab
Multi-Material Proportional Topology Optimization Using Adaptive Quadtree Sbfe Framework, Natchanon Chantab
Chulalongkorn University Theses and Dissertations (Chula ETD)
This thesis presents a novel approach to multi-material Proportional Topology Optimization (PTO) by integrating an automatic image-based quadtree element (2D) structure with the Scaled Boundary Finite Element framework (SBFE). Our method minimizes compliance or maximizes mechanical stiffness of multi-material structures while adhering to volume fraction constraints for each material. Design variables, proportionally weighted from 0 to 1, correspond to compliance values in optimization loops without sensitivity values. Additionally, a material interpolation scheme spatially separates material behaviors. An adaptive quadtree algorithm captures local area element details, reducing memory usage, solution times, and improving numerical accuracy. Implemented in finite element analysis using …
Development Of Technetium-99m Labeled Psma For Spect Prostate Cancer Imaging, Kalapaphuk Tachatumvitoon
Development Of Technetium-99m Labeled Psma For Spect Prostate Cancer Imaging, Kalapaphuk Tachatumvitoon
Chulalongkorn University Theses and Dissertations (Chula ETD)
Technetium-99m (Tc-99m) is the most employed radionuclide in nuclear imaging diagnosis because of its ideal physiochemical properties and ready availability. It particularly suitable for Single Photon Emission Computed Tomography (SPECT), leading to cost-effective compared to other radionuclides. This study consists of two aims to expand the utilization of Tc-99m radiopharmaceutical for prostate cancer which is one of the highest incidence rates and mortality cancer among men. Currently, Tc-99m radiopharmaceutical for SPECT diagnosis is not clinically available for prostate cancer. Firstly, the new formulation for Tc-99m complexation with PSMA-617, a current ligand for radionuclide therapy of prostate cancer with lutetium-177 (Lu-177), …
Comparative Assessment Of Environmental And Post- Occupancy Evaluation Of Green Buildings Vs Conventional Buildings, Wint Thiri Marn
Comparative Assessment Of Environmental And Post- Occupancy Evaluation Of Green Buildings Vs Conventional Buildings, Wint Thiri Marn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Due to increasing office space demand and rising rental rates, stakeholders seek cost-effective alternatives that align with sustainability goals. Therefore, green building offers an extensive solution particularly in growing office building rental rates and the need for cost-effective options that are consistent with environmentally conscious goals. Using the IPCC standard, the study assessed emissions across Scope 1 (refrigerant fugitive emissions) and Scope 1 emission from (Wastewater treatment system), Scope 2 (energy consumption emissions), and Scope 3 (emissions from water consumption, and waste generation). Scope 1 emissions are found to vary due to the usage of water-based fire-retardant systems, but they …
Sustainable Toughening Of Polylactic Acid With Ultra-Fine Fully Vulcanized Powdered Natural Rubber, Reza Gholami
Sustainable Toughening Of Polylactic Acid With Ultra-Fine Fully Vulcanized Powdered Natural Rubber, Reza Gholami
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study investigated the sustainable toughening of polylactic acid (PLA) by incorporating ultra-fine fully vulcanized powdered natural rubber graft-copolymerized with poly-styrene-co-acrylonitrile (UFPNR-SAN). We investigated the effect of the styrene-to-acrylonitrile ratio (ST:AN) used during the grafting process on the final UFPNR-SAN compatibility with PLA. The ST:AN ratio was systematically varied during the grafting reaction to prepare UFPNR-SAN with a range of different surface energies. The ST:AN ratio of 4:1 resulted in higher compatibility of UFPNR-SAN with the PLA matrix among other ratios. This could be explained by the desirable interfacial interactions and better dispersion shown by the contact angle measurements and …
Real-Time Polyp Analysis On Endoscopic Images Using Deep Learning Approach: Detection, Characterization And Size Estimation, Phanukorn Sunthornwetchapong
Real-Time Polyp Analysis On Endoscopic Images Using Deep Learning Approach: Detection, Characterization And Size Estimation, Phanukorn Sunthornwetchapong
Chulalongkorn University Theses and Dissertations (Chula ETD)
As medical devices advance, doctors adopt endoscopes to perform endoscopes for gastrointestinal disease screenings. For colonoscopy, skills such as polyp detection, polyp characterisation, and polyp size estimation needed to be practised while screening patients. This work aims to develop a deep learning model for performing polyp detection, characterisation, and size estimation to assist fellow doctors in these tasks. To maximise usability in assisting fellow doctors, the model must be able to perform in a real-time fashion. The work utilises existing object detection models for performing size estimation tasks. With the problems of data imbalances, we use depth information but without …
Shape Memory Polymer Based On Copolybenzoxazines: Effects Of Chain Length Of Aliphatic Monoamines On Shape Memory Performance, Attachai Sriwattana
Shape Memory Polymer Based On Copolybenzoxazines: Effects Of Chain Length Of Aliphatic Monoamines On Shape Memory Performance, Attachai Sriwattana
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research was successful in completely synthesizing benzoxazine copolymers for shape memory polymers (SMPs) by mixing bisphenol A-aniline (BA-a) and bisphenol A-aliphatic monoamines of various chain lengths (BA-aMAs). Our studies have shown that shorter chain lengths will provide higher crosslinking densities, which play an important role in promoting the stiffness of the polymer, resulting in a higher shape-fixity ratio (Rf). While longer chains result in a lower crosslinking density and a larger free volume, thus promoting a higher shape-recovery ratio (Rr), Therefore, selecting the appropriate aliphatic monoamine chain length is crucial. From the study of this work, it was found …
Implementing The Circular Economy Concept In Construction Supply Chain Management Of Modular Steel Projects, Thet Htar San
Implementing The Circular Economy Concept In Construction Supply Chain Management Of Modular Steel Projects, Thet Htar San
Chulalongkorn University Theses and Dissertations (Chula ETD)
The circular economy is a modern economic model where the value of products, materials, and resources is maintained in the economy as long as possible, whereas the generation of waste is minimized. The current linear take-make-dispose model prevalent in construction supply chain management is increasingly unsustainable, marked by significant resource wastage and environmental impacts. The conventional linear supply chain models in modular steel construction contribute to unsustainable resource utilization and environmental impacts. This research explores the transition from linear to circular supply chain models. We identify key actors, potential barriers, and opportunities for implementing circular economy practices in modular steel …
Stability Analysis Of Cellular Steel Plane Frames, Voraphol Horsangchai
Stability Analysis Of Cellular Steel Plane Frames, Voraphol Horsangchai
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research presents a comprehensive investigation of the global stability of cellular steel columns, beam-columns, and frames. For the cellular steel columns, the existing equation for predicting the elastic buckling load is improved to account for the local bending deformation of the web posts. Subsequently, the column strength equation is analytically developed from the energy approach. The second-order inelastic analysis is performed using 3D finite element (FE) models and validated against the experimental results. The validated FE models are then employed to assess the developed column strength curve and examine the influence of initial imperfections on the critical strength of …
Single Image Super Resolution Using Deep Attention Network, Jagrati Talreja
Single Image Super Resolution Using Deep Attention Network, Jagrati Talreja
Chulalongkorn University Theses and Dissertations (Chula ETD)
This thesis introduces two innovative frameworks for Single Image Super Resolution (SISR) that enhances image quality while optimizing computational efficiency. The motivation for this research is driven by the need to overcome the limitations of current SISR techniques like capturing long-range dependencies, enhancing multi-scale feature learning, mitigating over-smoothing, and managing computational demands. The choice to incorporate attention mechanisms in both frameworks is motivated by their proven ability to allow the model to focus on the most relevant parts of the image, thereby improving the reconstruction of high-resolution details from low-resolution inputs. By integrating attention mechanisms with inception blocks, the proposed …
Effects Of A Therapeutic Lifestyle Modification Intervention On Cardio-Metabolic Health, Sexual Functioning, And Health-Related Quality Of Life In Perimenopausal Chinese Women: A Randomized Controlled Trial, Yuru Wang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: Our study aimed to explore the effects of a therapeutic lifestyle modification (TLM) intervention on cardiometabolic health, sexual functioning, and health-related quality of life in perimenopausal Chinese women. Methods: This was a 12-week, two-parallel arm, randomized controlled trial conducted in the First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming City, China. Ninety-four eligible perimenopausal women aged between 40 and 55 years were randomly assigned to either a TLM intervention or usual care at a 1:1 ratio. Menopause-specific quality of life (MENQOL), female sexual function index (FSFI), pelvic floor muscle strength (PFMS), and composite cardiometabolic biomarkers were evaluated …
Comparison Of The Effects Of Dynamic Seat Cushion At Low Back And Buttocks On The Number Of Postural Shifts And Body Perceived Discomfort In Office Workers, Narumon Roynarin
Comparison Of The Effects Of Dynamic Seat Cushion At Low Back And Buttocks On The Number Of Postural Shifts And Body Perceived Discomfort In Office Workers, Narumon Roynarin
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study compared the number of postural shifts and body perceived discomfort while leaning and sitting on air-filled seat cushion for 1-hour in healthy office workers. Sixty office workers typed a standard text at a computer workstation for an hour in three sitting conditions: leaning on a seat cushion placing behind the low back, sitting on a seat cushion placing under the buttocks, and sitting without a seat cushion (a control condition). The number of postural shifts, average pressure (AP), peak pressure (PP), and frequency of sitting posture were collected using a seat pressure mat device. Body perceived discomfort at …
Blended Program And Its Impact On Knowledge, Attitude And Help-Seeking Intention Of Conflict-Related Sexual Violence Among Internally Displaced People In Northern Myanmar Camps: A Quasi-Experimental Study, Chit Pyae Pyae Han
Chulalongkorn University Theses and Dissertations (Chula ETD)
Introduction As a result of several military coups and internal armed conflicts, Myanmar has the longest history of civilian wars in the world. Human rights violations, gender-based violence, and sexual violence have become more widespread as a result of extensive conflicts and humanitarian crises. The United Nations is concerned about the detrimental consequences of sexual violence in military situations. A community-based program designed to prevent sexual violence is crucial in mitigating risk factors and enhancing protective factors Methods The two-group quasi-experimental study evaluated the impact of a community-based program to prevent sexual violence and examined the experiences of survivors among …
Effects Of A Game On A Smartphone (“Pilotgold”)To Prevent Non-Specific Neck Pain Among Office Workers:A 6-Month Cluster-Randomised Controlled Trial, Natchanon Intipanya
Effects Of A Game On A Smartphone (“Pilotgold”)To Prevent Non-Specific Neck Pain Among Office Workers:A 6-Month Cluster-Randomised Controlled Trial, Natchanon Intipanya
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: To evaluate the effects of a smartphone game for active neck movement exercise on perceived neck discomfort, new onset neck pain, and active cervical range of motion (ROM) among high-risk office workers. Methods: A 6-month prospective cluster-randomized controlled trial was conducted involving 100 healthy but high-risk office workers from nine organizations. They were randomly assigned at the cluster level into either the intervention group (n = 50), who received a smartphone game to play twice a day on workdays for 6 months, or the control group (n = 50), who received a placebo seat pad to use while sitting. …
Role Of Grb2 Intracellular Localization In Progesterone Receptor Positive Breast Cancer, Nattamolphan Wittayavimol
Role Of Grb2 Intracellular Localization In Progesterone Receptor Positive Breast Cancer, Nattamolphan Wittayavimol
Chulalongkorn University Theses and Dissertations (Chula ETD)
Progesterone receptor (PR) extranuclear signaling mediates mainly through PR polyproline domain (PPD) interaction with SH3 domain of cytoplasmic signaling molecules. PR-PPD interfered with Grb2-SOS binding through SH3 interaction resulting in decreased cell proliferation and correlates with a good prognosis in PR positive breast cancer. Grb2 is a key adaptor molecule and expressed in both nucleus and cytoplasm. We hypothesized that change in Grb2 localization alters PR transcription resulting in better clinical outcomes in PR positive breast cancer. BT-474 breast cancer cells expressing inducible Grb2-SV402x (nuclear Grb2, nuGrb2) or Grb2-MYR (membrane Grb2, memGrb2) were constructed. MemGrb2-BT-474 showed higher levels of PR …
Knowledge, Attitude And Practice Of Human Papilloma Virus Vaccination Among Reproductive Age Women In Mandalay City, Myanmar: A Cross-Sectional Study, Kyi Thu
Chulalongkorn University Theses and Dissertations (Chula ETD)
Cervical cancer is the fourth most common type of cancer among women all over the world. HPV infection, the most sexually transmitted viral infection, is responsible for about 95% of cases of cervical cancer. The study aims to investigate the association between socio-demographic characteristics, knowledge level, and attitude level toward the practice of HPV vaccination among reproductive age women in Mandalay City, Myanmar. The cross-sectional study was conducted in May 2024 among reproductive age women in Mandalay City in Myanmar. The study used an online, standard questionnaire. Descriptive statistics, simple logistic regression, and multiple logistics regression models were used for …
Roles Of Progesterone Signaling On Dna Repair And Cell Survival In Ovarian Cancer Cells, Pattarasiri Rangsrikitphoti
Roles Of Progesterone Signaling On Dna Repair And Cell Survival In Ovarian Cancer Cells, Pattarasiri Rangsrikitphoti
Chulalongkorn University Theses and Dissertations (Chula ETD)
Every year over 300,000 women worldwide are diagnosed with ovarian cancer and half of these patients die from this disease. The symptoms of ovarian cancer are very general and often confused with other common female diseases making ovarian cancer a challenging disease to diagnose and treat. Platinum-based chemotherapy, including cisplatin, stands as the first-line treatment for ovarian cancer. However, chemotherapy resistance remains a continuing problem, contributing to a high mortality rate. Progesterone receptor (PR) signaling has been implicated in various aspects of ovarian cancer biology. Clinical studies show a positive correlation between PR expression, improved patient survival and cisplatin response, …
Perception Of Academic Stress And Family Relationship On Mental Well-Being Among Pharmacy Students At Chulalongkorn University In Thailand: A Cross-Sectional Survey Study, Chompunoot Prasongpol
Perception Of Academic Stress And Family Relationship On Mental Well-Being Among Pharmacy Students At Chulalongkorn University In Thailand: A Cross-Sectional Survey Study, Chompunoot Prasongpol
Chulalongkorn University Theses and Dissertations (Chula ETD)
University students' mental health and well-being have gained more global attention due to their increasing influence on health and societal issues. The cross-sectional study, conducted in May 2024 among undergraduate Chulalongkorn University pharmacy students in Thailand, aims to investigate the proportion of mental well-being levels and determine the relationship between general characteristics, perceptions of academic stress, and family relationships toward mental well-being levels among pharmacy students at Chulalongkorn University. The study used an online, self-administered questionnaire. Descriptive statistics, simple logistic regression, and multiple logistic regression models were employed for data analysis. Out of 289 pharmacy students, 199 were predominantly female …
Knowledge Attitude And Practice Of Who Mental Health Guidelines For Non-Specialist Primary Healthcare Providers In Wuhua District, Kunming, People's Republic Of China: A Cross-Sectional Study, Liesha Luohe
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: The 'Healthy China 2030' policy emphasizes the importance of mental healthcare at the primary healthcare level. Globally, primary healthcare(PHC) service delivery is considered the most effective approach for managing mental health (MH) disorders. The WHO’s mental health gap intervention guide version 2 (mhGAP-IG.v2), is a decision support tool for non-specialists for the assessment, management, and follow-up of mental, neurological, and substance use disorders. However, no studies have assessed primary healthcare providers’ (HCPs) knowledge, attitudes, and practices on MH services in the western part of China. Objectives: To determine the PHC providers’ characteristics and MH service provision level in Wuhua …
Ultrasound-Assisted Extraction Of Cannabis Sativa And Biological Activities Assessments For Dermatological Application, Pannita Kongtananeti
Ultrasound-Assisted Extraction Of Cannabis Sativa And Biological Activities Assessments For Dermatological Application, Pannita Kongtananeti
Chulalongkorn University Theses and Dissertations (Chula ETD)
Cannabis sativa L. is a medicinal plant that has long been used in Thai traditional medicine and is still widely used today, with many uses in pharmaceuticals, including the treatment of skin infections. It contains a complex mixture of secondary metabolites, including cannabinoids and non-cannabinoid-type constituents, especially detla-9-tetrahydrocannabinol (THC), cannabidiol (CBD), and terpenes. However, fewer studies of cannabis have been reported regarding its anti-aging potential by investigating tyrosinase inhibition activity. In this study, ultrasound-assisted extraction (UAE) of 5 different parts of Cannabis sativa L., the determination of bioactive compounds using GC–MS/MS and the assessment of their biological properties related to …
Associated Factors With Suicide Mortality In Thailand:A Mediating Roles Of Urban And Rural Areas, Kajohnsak Tangkwampien
Associated Factors With Suicide Mortality In Thailand:A Mediating Roles Of Urban And Rural Areas, Kajohnsak Tangkwampien
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Suicide is a global public health problem that affects individuals, families, and communities. The World Health Organization (WHO) estimates that more than 700,000 people die by suicide worldwide each year. Despite the significance of this issue, important factors like rural and urban settings, which have different definitions in each country and result in specific contextual effects on suicide, are overlooked. Objectives: To understand the role of living in urban and rural as mediator on the associated factors (socio-demographic factors, mental and physical problems, effect from COVID-19, economic factors, relationship problems, history of self-harm, and warning signs, method of suicide) …
Association Between Greenness And Environmental Parameters Exposure And Depression Among Residents In Bangkok, Thailand: An Ecological Longitudinal Study, Wilaipak Nilsalai
Association Between Greenness And Environmental Parameters Exposure And Depression Among Residents In Bangkok, Thailand: An Ecological Longitudinal Study, Wilaipak Nilsalai
Chulalongkorn University Theses and Dissertations (Chula ETD)
Depression and mental health issues are on the rise, and it is hypothesized that environmental factors may play a role in the development of these diseases. Greenness is one of the potential factors, and this study aims to investigate the relationship between living in greener areas and depression incidence in Bangkok. This is an ecological longitudinal study using secondary data documented between 2018 and 2020, utilizing data on depression (ICD-10 F32, F33), environmental parameters (PM2.5 (µg/m3), temperature (ºC), relative humidity (RH; %), and demographic variables (population density, number of communities, number of hospitals, number of healthcare centers, and divorce rate) …
Effectiveness Of Facebook Breastfeeding Support Group On Exclusive Breastfeeding Among Myanmar Migrant Mothers In Samut Sakhon Province, Thailand: A Randomized Controlled Trial, Zayar Lynn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Given the widespread popularity of mobile health technology nowadays, conducting health education and behaviour change intervention through Facebook groups is a simple and efficient way to promote exclusive breastfeeding. However, limited studies have been investigating its effectiveness. This study aimed to assess the effectiveness of Facebook Breastfeeding Support Group on exclusive breastfeeding among Myanmar migrant mothers in Samut Sakhon Province, Thailand. A 2-arm, parallel-group, randomized controlled trial was conducted with 198 pregnant mothers between 28th and 34th weeks of gestation at the Antenatal Care clinic of Samut Sakhon Hospital. The intervention group (n=99) received breastfeeding related information and experience sharing …
Application Of Machine Learning In Assessing Spatial Distribution Patterns Of Soil Microplastics: A Case Study Of The Bang Pakong Watershed, Thailand, Ugochukwu Ihezukwu
Application Of Machine Learning In Assessing Spatial Distribution Patterns Of Soil Microplastics: A Case Study Of The Bang Pakong Watershed, Thailand, Ugochukwu Ihezukwu
Chulalongkorn University Theses and Dissertations (Chula ETD)
Microplastics (MPs) are persistent environmental pollutants introduced through various factors. Understanding the spatial distribution characteristics of MPs is crucial for developing effective mitigation strategies. However, the relationship between MPs and their covariables remains largely unexplored. In this study, we investigated the abundance of MPs in 40 soil samples from different land-use types in the Bang Pakong Watershed and assessed the applicability of machine learning models for predicting the spatial distribution patterns of soil MPs. The samples were divided into three categories: 1.2 µm-500 µm, 500 µm-1 mm, and 1-2 mm. They were analyzed using ZnCl2 density separation, H2O2 digestion process, …
Electrophysiological Characteristics Of A Novel Scn5a Mutation (I239v Or M1487k) In The Cardiac Voltage-Gated Sodium Channel, Vichaya Auvichayapat
Electrophysiological Characteristics Of A Novel Scn5a Mutation (I239v Or M1487k) In The Cardiac Voltage-Gated Sodium Channel, Vichaya Auvichayapat
Chulalongkorn University Theses and Dissertations (Chula ETD)
Cardiac voltage-gated sodium channels (NaV1.5) are essential to generate sodium current (INa) and regulate cardiac electrical conduction. Mutations in NaV1.5 can lead to cardiac disorders such as Brugada syndrome and Long QT Syndrome type 3 (LQTS3), potentially resulting in sudden cardiac death. Mutations p.I239V and p.M1487K have been identified in LQTS3 patients. The p.I239V mutation was found in a patient with mild symptoms and in family members who experienced sudden cardiac death, while the p.M1487K mutation is associated with more severe symptoms. This study aims to investigate the impact of these mutations on INa from NaV1.5 activities, which could cause …
Superconductivity In 2d Janus Monolayers And Bilayers, M Munib Ul Hassan Noor Ul Taqi
Superconductivity In 2d Janus Monolayers And Bilayers, M Munib Ul Hassan Noor Ul Taqi
Chulalongkorn University Theses and Dissertations (Chula ETD)
Janus transition metal dichalcogenides (J-TMDCs) is a new class of materials which shares the same honey-comb structure as graphene and conventional transition metal dichalcogenides (TMDCs) in monolayer. They have versatile physical and chemical properties which mainly feature out from their broken out of plane symmetry. This asymmetry results in an intrinsic electric field orthogonal to their plan. The presence of an intrinsic electric field gives rise to many novel properties like the Rashba effect, increased charge carrier concentration, Schottky barrier, excitons, and superconductivity. Also, they exist in multiple structural phases like, 2H, 1T, 1T' with the electrical properties shifting from …
Viral Rna M6a Methylome Profilingusing Nanopore Direct Rna Sequencing, Thada Sukprasong
Viral Rna M6a Methylome Profilingusing Nanopore Direct Rna Sequencing, Thada Sukprasong
Chulalongkorn University Theses and Dissertations (Chula ETD)
N6-methyladenosine (m6A) modification is the most common RNA modification in eukaryotic mRNAs and viruses, playing a pivotal role in gene regulation. Currently, nanopore sequencing has emerged as a technique capable of identifying m6A positions by observing differences in ionic currents between wild-type and METTL3-knockout samples. This method sequences native RNA strands directly, bypassing reverse transcription. The xPore program compares the ionic currents from both samples to determine m6A positions and their modification rates. However, obtaining METTL3-knockout RNAs is not always achievable. To address this limitation, m6Anet predicts m6A positions and provides the probability of m6A sites using only wild-type RNA. …
Metabolomic Analysis Of Lungs From Breast Cancer Metastatic Mice Models Treated With Thai Traditional Medical Formulary, Kotchanipa Rukruam
Metabolomic Analysis Of Lungs From Breast Cancer Metastatic Mice Models Treated With Thai Traditional Medical Formulary, Kotchanipa Rukruam
Chulalongkorn University Theses and Dissertations (Chula ETD)
Triple-negative breast cancer (TNBC) is a highly invasive subtype, leading to lung metastasis in 40% of patients with TNBC metastasis. Lung metastases significantly reduce median survival compared to other breast cancer types. Hence, there are efforts to investigate TNBC treatments, including modern and alternative therapies. The Thai traditional medical formulary (TTMF) is broadly used as an alternative treatment for Thai cancer patients. However, there are no studies on metabolic changes after treatment in advanced TNBC. Additionally, obtaining metabolites from biological samples is challenging due to the lack of a universal protocol for metabolite extraction. Consequently, this thesis aimed to first …
Inhibition Of Chondrocyte Apoptosis Via Fas/Fasl System In Knee Osteoarthritis Patients, Ousakorn Kamenkit
Inhibition Of Chondrocyte Apoptosis Via Fas/Fasl System In Knee Osteoarthritis Patients, Ousakorn Kamenkit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Osteoarthritis (OA) is a degenerative rheumatic disease characterized by articular cartilage degeneration. This articular cartilage degradation is positively correlated with chondrocyte apoptosis. The Fas/Fas ligand (FasL) system is part of the extrinsic apoptosis pathway that regulates cell death through the binding of Fas on target cells to FasL on effector cells. Although Fas+ chondrocytes have been identified and the Fas/FasL system has been implicated in this apoptotic process, the apoptosis through chondrocyte-to-FasL+ cell interaction remains unclear. Therefore, this study aims to investigate Fas/FasL-mediated chondrocyte apoptosis focusing on cell-to-cell interactions. In our study, we conducted ex vivo experiments using flow cytometry …
Value-Added Natural Fiber As A Biocompatible Substrate For Chemical Sensor Applications, Wisarttra Phamonpon
Value-Added Natural Fiber As A Biocompatible Substrate For Chemical Sensor Applications, Wisarttra Phamonpon
Chulalongkorn University Theses and Dissertations (Chula ETD)
This dissertation focuses on the improvement and value added of natural fiber extracted from the UHT milk carton waste, and raw silk cocoon to fabricate the biocompatible substrate for chemical sensors, principally in colorimetric and electrochemical sensors, which is allocated in 3 main parts. Initially, the background studying of the surface modification and the function of natural fiber based chemical sensor for food quality control and clinical diagnosis will be explained in a review article. Subsequently, the development of recycled cellulose from UHT milk carton waste as a novel substrate of dual lactate sensor for milk spoilage indication will be …