Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (1690)
- Engineering (1183)
- Physical Sciences and Mathematics (1117)
- Social and Behavioral Sciences (951)
- Chemical Engineering (511)
-
- Arts and Humanities (469)
- Chemistry (431)
- Life Sciences (410)
- Business (353)
- Economics (336)
- Medical Sciences (335)
- Dentistry (299)
- Veterinary Medicine (280)
- Pharmacy and Pharmaceutical Sciences (274)
- Public Health (272)
- Finance and Financial Management (271)
- Computer Sciences (258)
- Education (241)
- Sociology (177)
- Civil and Environmental Engineering (175)
- Mathematics (158)
- Environmental Sciences (141)
- Law (141)
- Communication (134)
- Communication Technology and New Media (134)
- Mass Communication (134)
- Electrical and Computer Engineering (121)
- Operations Research, Systems Engineering and Industrial Engineering (116)
- English Language and Literature (113)
- Industrial Engineering (113)
Articles 1411 - 1440 of 6471
Full-Text Articles in Entire DC Network
Breast Cancer Characterization Using Artificial Intelligence In Screening And Diagnostic Mammogram Of Thai Women, Jaroonroj Wongnil
Breast Cancer Characterization Using Artificial Intelligence In Screening And Diagnostic Mammogram Of Thai Women, Jaroonroj Wongnil
Chulalongkorn University Theses and Dissertations (Chula ETD)
Breast cancer is a significant health issue in Thailand, necessitating accurate detection and characterization for effective treatment. This thesis focuses on leveraging artificial intelligence techniques to develop breast cancer screening and diagnosis using mammography images of Thai women. Furthermore, detecting and classifying mammography calcifications, crucial indicators of malignant or benign conditions had also been focused using RCNN and YOLOv4 in this study. AlexNet CNN was developed to increase the robustness of the RCNN model. AlexNet was tested with three different datasets, each consisting of 4,000 cropped ROI images. These datasets were divided into an 80% training set and a 20% …
Targeting Bladder Cancer Cells By Cendr Peptides Specifically Recognized Neuropilin-1 Enhances Tumor Killing Efficacy Of Drug-Carrying Nanoparticles, Sotida Kayem
Chulalongkorn University Theses and Dissertations (Chula ETD)
Chemotherapy is still widely used for treating cancers including bladder cancer (BlCa), but it accompanies serious side effects. Therefore, a new targeted therapeutic approach that can precisely target and kill cancer cells but leave normal cells unharmed is required. Nanoparticles are widely studied as a potential tool for carrying out anticancer drugs and targeting cancer cells aiming at increasing the treatment efficiency. In this study, we aimed to fabricate human serum albumin nanoparticles (HSA-NPs), load them with doxorubicin (DOX) and coat them on the particles’ surface with tumor-targeting peptides for selectively targeting BlCa cells. The tumor-targeting peptides used in this …
The Diagnostic Value Of Bispectral Index For Assessing Sleep Quality After Elective Surgery In Intensive Care Unit, Pongpol Sirilaksanamanon
The Diagnostic Value Of Bispectral Index For Assessing Sleep Quality After Elective Surgery In Intensive Care Unit, Pongpol Sirilaksanamanon
Chulalongkorn University Theses and Dissertations (Chula ETD)
Sleep abnormality is common in the intensive care unit (ICU). Monitoring and improving sleep quality may help recovery and improve outcomes from a major illness. Although polysomnography is a gold standard for measuring sleep quality, routine use is impractical due to cost and complexity. This study aimed to investigate the diagnostic accuracy of an alternative monitor, the Bispectral Index (BIS), compared to polysomnography for evaluating the quality of postoperative sleep in the ICU. This was a prospective observational study. Enrolled patients were monitored with both BIS and polysomnography during the first night after surgery. Results: Thirty-three patients were enrolled. The …
Gene-Edited Induced Pluripotent Stem Cell-Derived Macrophages For Enhancing Antibody-Dependent Anti-Cancer Response In Cancer Immunotherapy, Bongkotchanok Danrungcharoen
Gene-Edited Induced Pluripotent Stem Cell-Derived Macrophages For Enhancing Antibody-Dependent Anti-Cancer Response In Cancer Immunotherapy, Bongkotchanok Danrungcharoen
Chulalongkorn University Theses and Dissertations (Chula ETD)
Macrophages are promising for cellular cancer immunotherapy due to their high penetration capability and ability to modulate the tumor microenvironment. They enhance the anti-cancer activity of therapeutic antibodies by mediating antibody-dependent cellular phagocytosis (ADCP) and cytotoxicity. Our study aims to develop engineered macrophages with enhanced antibody-mediated anti-cancer activity from induced pluripotent stem cells (iPSCs), providing a platform for multiple genome edits and scalable manufacturing. We introduced gene modifications into iPSCs using CRISPR-mediated HDR to generate human iPSC-derived macrophages (iMacs). First, we created a human iPSC line containing a mutant CD16 resistant to ADAM17 cleavage using CRISPR-mediated genome editing. Macrophages derived …
Dual Delivery Of Oxygen And Anticancer- Agent By Protein Microparticles To Increase Therapeutic Efficacy In Hepatocellular Carcinoma, Siwanut Pummarin
Dual Delivery Of Oxygen And Anticancer- Agent By Protein Microparticles To Increase Therapeutic Efficacy In Hepatocellular Carcinoma, Siwanut Pummarin
Chulalongkorn University Theses and Dissertations (Chula ETD)
Hepatocellular carcinoma (HCC) largely contributes to the cancer-related death. Chemotherapy is one of the key treatments for advanced HCC. However, severe side effects are still the main issue for the chemotherapeutic use, because the drug kills not only cancer cells, but also the non-cancerous cells. Targeted therapy has been used to increase therapeutic efficacy and simultaneously reduce the side effect. The several drug delivery systems that can carry anticancer agents and specifically deliver the drugs to cancer cells have been developed and tested. Upregulation of p32 expression in HCC has been reported, suggesting that it could be a specific tumor …
Factors Associated With Severity Of Depression And Suicidal Behaviors In University Students, Asara Vasupanrajit
Factors Associated With Severity Of Depression And Suicidal Behaviors In University Students, Asara Vasupanrajit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Depression is a mood disorder that is a significant risk factor for suicidal behaviors (SB). This study aimed to explore the influence of the potential factors of depression, encompassing adverse childhood experiences (ACEs), negative life events (NLEs), rumination, neuroticism, and the immune-inflammatory and nitro-oxidative (IO&NS) biomarkers on the severity of depression and SB among young adults. The effects of IO&NS biomarkers in psychiatric patients with SB were identified through systematic reviews and meta-analyses. A case-control study involving 118 participants was conducted to determine the association between psychological factors, including ACEs, NLEs, rumination, and neuroticism, and the depression phenome using partial …
Immunogenicity And Safety Of The Third Booster Dose With Homologous Or Heterologous Covid-19 Vaccine After Completing Primary Series Of Inactivated Vaccine (Coronavac) Or Adenovirus Vector Vaccine (Azd1222) In Thai Adults, Suvichada Assawakosri
Chulalongkorn University Theses and Dissertations (Chula ETD)
COVID-19 has spread across 200 countries, causing 705 million confirmed cases and 7 million deaths. Several vaccines have been approved by the World Health Organization to prevent the spread of the virus. The Omicron variant has become the predominant strain globally. Although most people have been vaccinated, primary doses of CoronaVac or AZD1222 may not provide adequate protection against the Omicron variants. Studies show that vaccine-induced immunity has declined over time, leading to increase of breakthrough infection cases. A heterologous booster administered after primary vaccination, is hypothesized to enhance the immune response against the newly emerged SARS-CoV-2 variant. This study …
Corneal Nerve Parameters In Prodromal Parkinson's Disease Patients, Sasi Yaisawang
Corneal Nerve Parameters In Prodromal Parkinson's Disease Patients, Sasi Yaisawang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background and Objectives: Peripheral neuropathy often precedes central degeneration and motor decline in Parkinson’s disease (PD). Here, we sought to evaluate corneal nerve parameters as markers of peripheral neuropathy comparing patients with prodromal PD, PD, and healthy controls using confocal microscopy. Methods: We conducted a cross-sectional study involving 53 participants (17 prodromal PD, 18 PD, 18 healthy controls). Prodromal PD was based on predetermined criteria including patients with REM sleep behavior disorder or a first degree relative with PD with 1 of 3 prodromal symptoms including constipation, hyposmia, or depression. Corneal nerve fiber length (CNFL), density (CNFD), branch density (CNBD), …
An Implementation Research Of Hiv Prevention, Testing, And Care Through Community-Based Services Among Msm Population In South Sulawesi, Indonesia, Sudirman Sudirman
An Implementation Research Of Hiv Prevention, Testing, And Care Through Community-Based Services Among Msm Population In South Sulawesi, Indonesia, Sudirman Sudirman
Chulalongkorn University Theses and Dissertations (Chula ETD)
Indonesia is one of the countries with the most rapidly growing HIV epidemics in Asia. Indonesia is also one of the countries that failed to meet the target of 90 UNAIDS by 2020, despite various programs and services that have been issued. In 2015, the WHO recommended the expansion of HIV services beyond the clinical setting, of which community-based service (CBS) is one of the recommendations. This study aims to identify the challenge in HIV prevention, testing, and care and how to improve it by implementing community-based services (CBS) among the MSM population in South Sulawesi, Indonesia. This research is …
The Causal Relationships Of Work-Life Balance, Psychological Well-Being, Burnout, And Related Factors Among Public Secondary School Teachers In Bangkok: A Mixed-Method Research, Gunchanon Khawda
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study is a parallel mixed-method research, consisting of quantitative and qualitative studies. The objective is to examine the causal relationships among work-life balance, psychological well-being, burnout, emotional intelligence, emotion regulation, and psychological capital among public secondary school teachers in Bangkok. The quantitative results revealed that the study comprised 436 teachers, with an average age of 35.12 years old (SD = 9.56). The structural equation modeling analysis found that the model fit the empirical data (Chi-square = 348.89, df = 172, p < 0.001, Chi-square/df = 2.03, RMSEA = 0.05, GFI = 0.93, AGFI = 0.91, CFI = 0.97). Emotional intelligence had a significant positive effect on work-life balance (Beta = 0.43, p = 0.002) and psychological well-being (Beta = 0.29, p = 0.001). Psychological capital also had a significant positive effect on work-life balance (Beta = 0.35, p = 0.03) and psychological well-being (Beta = 0.51, p < 0.001). The qualitative study included in-depth interviews with 6 school administrators and focus group discussions with 20 teachers. The qualitative results demonstrated that school administrators and teachers had a convergent opinion on factors contributing to poor work-life balance, such as workload apart from teaching, urgent work during holidays, the burden of caring for family members, and financial debt. Additionally, factors contributing to teacher burnout, such as excessive workload, disliked assignments, monotonous tasks, and students lacking motivation to study, were identified. The merged results of the quantitative and qualitative studies can be summarized in four topics: (1) Teachers’ good work-life balance affects better psychological well-being and happiness, while poor work-life balance might affect greater burnout; (2) Teachers’ emotional intelligence and psychological capital affect good work-life balance; (3) Teachers’ emotional intelligence and psychological capital might reduce burnout; and (4) Teachers' emotional intelligence and psychological capital positively influence psychological well-being. In conclusion, teachers with high levels of emotional intelligence and psychological capital are likely to have better work-life balance and psychological well-being; in turn, these might reduce their burnout.
ผลของการมีส่วนร่วมในห่วงโซ่การผลิตโลกของอุตสาหกรรมไทยต่อการจัดหาแหล่งวัตถุดิบจากในประเทศ, พิมพรรณ วุฒิพงศ์ประเสริฐ
ผลของการมีส่วนร่วมในห่วงโซ่การผลิตโลกของอุตสาหกรรมไทยต่อการจัดหาแหล่งวัตถุดิบจากในประเทศ, พิมพรรณ วุฒิพงศ์ประเสริฐ
Chulalongkorn University Theses and Dissertations (Chula ETD)
งานศึกษานี้ศึกษาผลของการมีส่วนร่วมในห่วงโซ่การผลิตโลก และผลของการใช้นโยบายส่งเสริมการลงทุนที่มีต่อการจัดหาแหล่งวัตถุดิบในประเทศไทย โดยอาศัยข้อมูลสำมะโนอุตสาหกรรมปี 2555 และปี 2560 ซึ่งแบ่งวิเคราะห์ข้อมูลระดับบริษัทในอุตสาหกรรมเป็น 14 กลุ่มอุตสาหกรรม และใช้ข้อมูลตัวบ่งชี้การมีส่วนร่วมในห่วงโซ่การผลิตโลกระดับอุตสาหกรรม เพื่อพิจารณาผลที่มีต่อการจัดหาแหล่งวัตถุดิบจากในประเทศ จากการศึกษาโดยแบบจำลอง Fixed Effects Model พบว่า การมีส่วนร่วมในห่วงโซ่การผลิตไปข้างหลังและภาพรวมการให้สิทธิประโยชน์จาก BOI มีผลเชิงลบต่อการจัดหาแหล่งวัตถุดิบจากในประเทศ และพบว่าการพิจารณาใช้นโยบายส่งเสริมการลงทุนร่วมกับการมีส่วนร่วมในห่วงโซ่การผลิตไปข้างหลัง หรือการกำหนดเงื่อนไขการให้สิทธิประโยชน์ตามคุณลักษณะเฉพาะของบริษัท เช่น ความเข้มข้นในการใช้ทุน สัดส่วนการร่วมลงทุนหรือถือหุ้นจากต่างประเทศ และสัดส่วนการส่งออกผลผลิตไปจำหน่ายต่างประเทศในระดับสูง ส่งผลเชิงลบต่อการจัดหาแหล่งวัตถุดิบในประเทศอย่างมีนัยสำคัญ อย่างไรก็ดี การให้สิทธิประโยชน์กับบริษัทที่อยู่ในอุตสาหกรรมที่มีระดับการมีส่วนร่วมในห่วงโซ่การผลิตโลกหรือมีผลิตภาพแรงงานสูงมีแนวโน้มจะจัดหาแหล่งวัตถุดิบในประเทศเพิ่มขึ้น ทั้งนี้ ผลการศึกษาพบว่าการใช้นโยบายส่งเสริมการลงทุนมีผลแตกต่างกันตามคุณลักษณะเฉพาะของบริษัทและของอุตสาหกรรมที่เลือกมาวิเคราะห์
Financial Statement Analysis: The Influence Of Yen’S Fluctuations On The Financial Performance Of A Japanese Firm (The Case Study Of Ngk Insulators, Ltd.), Kesinee Chaiyaphet
Financial Statement Analysis: The Influence Of Yen’S Fluctuations On The Financial Performance Of A Japanese Firm (The Case Study Of Ngk Insulators, Ltd.), Kesinee Chaiyaphet
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research explores the analysis of financial ratios to determine the consequences of yen fluctuations on NGK's financial performance. The assessment compares yen fluctuations with NGK's financial ratios over the 25-year period (1998-2022), employing Pearson correlation analysis to know the influence of yen fluctuations on NGK's financial performance. The research seeks to contribute to a deeper understanding of the complex interconnection between yen fluctuations and financial performance, offering insights valuable for managing currency risk in the Japanese financial landscape. According to the findings, yen fluctuations have a remarkable impact on NGK's financial performance across multiple ratios. Moreover, continuous monitoring of …
An Approach To Business Models For Agritourism Business, A Case Study Of Singha Park, Nat Poolsiri
An Approach To Business Models For Agritourism Business, A Case Study Of Singha Park, Nat Poolsiri
Chulalongkorn University Theses and Dissertations (Chula ETD)
Agritourism, blending agriculture and tourism, has emerged as a potent force in fostering rural economies and bridging urban-rural gaps worldwide. Singha Park, formerly Boon Rawd Farm, exemplifies this phenomenon, transforming into a premier agritourism destination in Chiang Rai, Thailand. This research endeavors to develop innovative marketing strategies tailored to Singha Park's unique agritourism offerings. Drawing upon a comprehensive review of relevant literature and Singha Park’s information, this study evaluates Singha Park's performance and proposes strategic marketing approaches to maximize its potential. Singha Park's evolution under the stewardship of Boon Rawd Brewery Company Limited, epitomized by its commitment to sustainability, community …
Strategic Analysis On The Development Of Chinese Fruit Trade, Zijie Zhao
Strategic Analysis On The Development Of Chinese Fruit Trade, Zijie Zhao
Chulalongkorn University Theses and Dissertations (Chula ETD)
China is one of the major players of fruit trade in the world, and the advancement of ‘the Belt and Road’ initiative and implement of RCEP provides new impetus for the sustainable growth of bilateral fruit trade. Based on an analysis of the culture background China, fruit production in China, overview of fruit industry in China and current status of fruit trade China, this study utilizes SWOT and PEST analysis to comprehensively investigate the competitiveness and growth potential of China fruit trade.
Sustainable Strategy: The Case Of Ngk Insulators, Benyapa Benjakul
Sustainable Strategy: The Case Of Ngk Insulators, Benyapa Benjakul
Chulalongkorn University Theses and Dissertations (Chula ETD)
A heightened awareness of environmental sustainability has emerged in recent years, influencing consumer and investor behavior. The concept of sustainability has become a prominent strategic focus within the automotive and auto parts industries. Companies such as NGK Insulators are recognized for their role in supplying environmentally conscious and innovative products to the automotive sector. This study examines NGK Insulators, a Japanese automotive parts manufacturer, and its dedication to environmental sustainability. Emphasizing sustainability as a core principle, NGK Insulators operates under a defined Environmental, Social, and Governance (ESG) strategy. The study portrays NGK Insulators as a company applying its unique ceramic …
Business Strategy Analysis Case Study : Ngk Insulators Company, Phatsumon Chernsiri
Business Strategy Analysis Case Study : Ngk Insulators Company, Phatsumon Chernsiri
Chulalongkorn University Theses and Dissertations (Chula ETD)
The global economic landscape is undergoing a significant transformation, driven by several key factors. One of the most prominent trends is the surging demand for electric vehicles (EVs), fueled by rising oil prices and heightened environmental concerns. This shift poses significant challenges for companies reliant on combustion vehicles and their parts, as they face declining sales and potential market stagnation. To navigate this evolving landscape and ensure their continued success, companies must proactively restructure their business structure and implement effective business management strategies. NGK Insulators has emerged as a case study in successful adaptation, demonstrating consistent sales growth amidst a …
The Factors Of Influencing Strategic Decision-Making And Enhancing Performance For Smes In China's Cultural And Creative Industry, Shuyu Xu
Chulalongkorn University Theses and Dissertations (Chula ETD)
This paper explores the influencing factors in the strategic decision-making process of small and medium-sized enterprises in China's cultural and creative industry through market-oriented theory and resource-based perspectives and analyzes how to help small and medium-sized enterprises in the cultural and creative industry improve their strategic decision-making effectiveness from four aspects: customer orientation, market agility, perception and learning ability. Specifically, this paper interviews managers or owners of six small and medium-sized enterprises in Xi'an, Shaanxi Province, China. After interview analysis, the above four points have a positive impact on improving the effectiveness of strategic decision-making of small and medium-sized enterprises …
Influence Of Brand Factors On Purchase Intentions In Thailand’S Garment Industry In Instagram, Zehong Du
Influence Of Brand Factors On Purchase Intentions In Thailand’S Garment Industry In Instagram, Zehong Du
Chulalongkorn University Theses and Dissertations (Chula ETD)
The rapid growth of social commerce has significantly transformed the landscape of consumer engagement, particularly within Thailand's garment industry. Leveraging Instagram as a pivotal platform, this study examines the impact of brand factors on the purchase intentions of Thai Instagram users. The research delves into how brand awareness, product uniqueness, perceived value, and brand trust collectively shape consumer buying behaviors. Employing a robust research framework, brand awareness and product uniqueness serve as independent variables, while perceived value and brand trust function as mediating variables, ultimately influencing purchase intention. Key findings indicate that brand recognition and product uniqueness markedly enhance perceived …
Determinants Of Vitamin And Mineral Supplement Purchases Among Generation Z, Phakorn Sirisathaworn
Determinants Of Vitamin And Mineral Supplement Purchases Among Generation Z, Phakorn Sirisathaworn
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study investigates the determinants of Vitamin and Mineral Supplement Purchases among Generation Z, focusing on age and income as key factors. A sample of 385 respondents aged 16-27 completed an 18-question survey, categorized by income levels (< 20,000 THB, 20,000 - 40,000 THB, 40,000 - 60,000 THB, 60,000 - 80,000 THB, and above 80,000 THB) for comprehensive analysis. Younger respondents, particularly those aged 16-18, predominantly belong to lower income brackets, reflecting early career or student statuses. Income levels increase with age, peaking among 25-27 year-olds, indicating greater economic capability. Consumption patterns closely align with income, where higher income groups exhibit higher supplement usage. Primary barriers for lower income groups include safety concerns and affordability, while motivations across all income brackets center on health improvement and immune support. Economic disparities influence purchasing behaviors, with lower income groups buying smaller quantities more frequently and higher income groups opting for bulk purchases less often. Preferences for organic ingredients and trusted brands are notable among higher income segments. The study underscores the economic sensitivity of lower income consumers to price changes and the resilience of higher income groups to economic fluctuations. These findings emphasize the role of income in shaping supplement consumption behaviors and suggest implications for targeted marketing and public health initiatives aimed at Generation Z.
The Balance Between Tradition And Innovation Incorporate Strategy, Yiqian Bu
The Balance Between Tradition And Innovation Incorporate Strategy, Yiqian Bu
Chulalongkorn University Theses and Dissertations (Chula ETD)
This article analyzes strategy of Italian family-owned business brand "B". We examine how this family business maintain family heritage while thriving for innovation .In recent years, Their market share has been expanded , The strategic potential of family businesses was recognized by both academics and practitioners, giving rise to further study. This article believes that innovative inheritance of excellent family business values and missions at the corporate strategic level is the key for family businesses to maintain their stable competitiveness in future market competition.
The Impact Of Living Arrangement On The Health Of The Elderly—Based On Clhls 2018, Ludan Cao
The Impact Of Living Arrangement On The Health Of The Elderly—Based On Clhls 2018, Ludan Cao
Chulalongkorn University Theses and Dissertations (Chula ETD)
The rapid demographic shift towards an aging population in China has brought the health status of the elderly to the forefront of state and societal concerns. Concomitant with socioeconomic development, the living arrangements of the elderly have undergone significant transformations, leading to variations in social support structures and, consequently, impacting their physical, mental, and self-reported health outcomes. This study investigates the correlation between living arrangements and the health status of the elderly population in China. Using data from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS), this study empirically examines the impact of solitary living on the health status of …
The Relationship Between Green Bonds And Carbon Productivity In China, Zhenxuan Chen
The Relationship Between Green Bonds And Carbon Productivity In China, Zhenxuan Chen
Chulalongkorn University Theses and Dissertations (Chula ETD)
This paper investigates the impact of green bond issuance on carbon productivity across various regions in China from 2014 to 2022. Utilizing panel data from 30 provinces, the study explores whether green bonds, as financial instruments, contribute to a low-carbon economy by enhancing the ratio of economic output to carbon emissions. Empirical analysis employs a fixed-effects model to account for unobserved heterogeneity and ensure robustness in findings. The results indicate a positive relationship between green bond issuance and carbon productivity, suggesting that regions actively issuing green bonds achieve higher economic efficiency relative to their carbon output. Additionally, the research examines …
Thailand Textile And Garment Industry：International Market Opportunities From An Economic Perspective, Yuanyuan Lu
Thailand Textile And Garment Industry：International Market Opportunities From An Economic Perspective, Yuanyuan Lu
Chulalongkorn University Theses and Dissertations (Chula ETD)
The textile and garment industry is a significant contributor to Thailand's economy, playing a vital role in employment, exports, and industrialization. This study explores the international market opportunities for Thailand's textile and garment sector from an economic perspective. Utilizing frameworks such as Porter's Five Forces, SWOT analysis, and PESTEL analysis, this research identifies the key challenges and opportunities within the industry. The findings reveal that while the industry faces challenges such as rising production costs, labor shortages, and outdated machinery, there are substantial opportunities for growth through technological advancements, sustainable practices, and international partnerships. The study highlights the need for …
Determination Of The Surface Dose Correction Factors For Various Detectors In Proton Scanning Therapy, Pakjira Saruang
Determination Of The Surface Dose Correction Factors For Various Detectors In Proton Scanning Therapy, Pakjira Saruang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Proton therapy delivers tumors doses precisely but concerns about skin toxicity due to energy dispersion beyond the Bragg peak remain. Accurate surface dose measurement is crucial for calculating the radiation dose patients receive. Studying factors that improve measurement accuracy is essential, as current methods are challenging and often inaccurate. This research aims to determine the surface dose correction factors (Scf) for various detectors in spot scanning beam proton therapy and study the effect of surface dose according to various clinical factors. The PTW Advanced Markus, PTW Roos chamber and IBA FC65-G Farmer chamber were utilized to measure the surface dose …
Prognostic Factors For Treatment Outcomes In Epilepsy Patients With Hippocampal Sclerosis In King Chulalongkorn Memorial Hospital, Pharanpong Taemeeyapradit
Prognostic Factors For Treatment Outcomes In Epilepsy Patients With Hippocampal Sclerosis In King Chulalongkorn Memorial Hospital, Pharanpong Taemeeyapradit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Study aimed to identify predictors and develop a guided prediction tool for persistent seizures in a large hippocampal sclerosis (HS) cohort to aid early referral for epilepsy surgery in at-risk patients. Materials and Methods: We studied patients with temporal lobe epilepsy and hippocampal sclerosis (TLE-HS). We evaluated demographic data, seizure characteristics, and MRI findings to identify predictors of persistent seizures. Cumulative incidence function and competing risk analysis were used. A prediction tool for persistent seizures was developed based on significant predictors. Results: Of 568 TLE-HS patients. Five predictors of persistent seizures were identified: seizure frequency >50 times/month, psychiatric comorbidity, …
Effect Of Control Of Fluid Balance On Sleep Apnea In Peritoneal Dialysis With Volume Overload State: A Pre- And Post- Experimental Study, Seelwan Sathitratanacheewin
Effect Of Control Of Fluid Balance On Sleep Apnea In Peritoneal Dialysis With Volume Overload State: A Pre- And Post- Experimental Study, Seelwan Sathitratanacheewin
Chulalongkorn University Theses and Dissertations (Chula ETD)
Sleep apnea is prevalent in end-stage kidney disease (ESKD) patients undergoing peritoneal dialysis (PD). Fluid overload and upper airway edema are suspected contributors, but the impact of fluid balance control on sleep apnea remains unexplored. We conducted a pre- and post-intervention study on 14 stable PD patients with volume overload. All underwent overnight polysomnography (PSG) at baseline. A fluid balance control intervention was implemented. Successful intervention was defined as maintaining actual body weight within 1.5 kg of estimated dry weight and reducing overhydration fluid. The primary outcome was a change in apnea-hypopnea index (AHI) assessed by polysomnography. Ten patients achieved …
The Effect Of High Dose Emblica Officinalis Fruit Powder On Cough Suppression During Advanced Diagnostic Bronchoscopy Compare To Dextromethorphan And Placebo: A Double Blinded Randomized Controlled Trial, Sarocha Phiphitsaengjan
The Effect Of High Dose Emblica Officinalis Fruit Powder On Cough Suppression During Advanced Diagnostic Bronchoscopy Compare To Dextromethorphan And Placebo: A Double Blinded Randomized Controlled Trial, Sarocha Phiphitsaengjan
Chulalongkorn University Theses and Dissertations (Chula ETD)
BACKGROUND Coughing during bronchoscopy related to patient’s discomfort and difficulty performing the procedure. EBUS bronchoscopy was found to be one of significant factors related to cough. Emblica officinalis (EO) is widely used as traditional herb, one of the effects is cough suppression and was found to be dose related. OBJECTIVES To study the efficacy of high-dose EO as oral premedication before EBUS bronchoscopy in cough suppression effect compared to dextromethorphan and placebo. METHODS Patients age 18 - 80 years old underwent EBUS bronchoscopy were randomized into 3 groups to take the drugs as premedication; EO 1500 mg, dextromethorphan (Dx) 60 …
Efficacy Of Lower Dose Of Dexamethasone Premedication In Patient Receiving Docetaxel-Based Chemotherapy In Preventing Hypersensitivity Reaction: A Randomized Controlled Trial, Sitthichai Chanmaniloet
Efficacy Of Lower Dose Of Dexamethasone Premedication In Patient Receiving Docetaxel-Based Chemotherapy In Preventing Hypersensitivity Reaction: A Randomized Controlled Trial, Sitthichai Chanmaniloet
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Infusion of docetaxel carries the risk of hypersensitivity reactions (HSR), prompting the use of dexamethasone (DEXA) premedication to mitigate this risk. However, the appropriate dosage has been a subject of debate. In our study, we investigated the efficacy of a lower dose of DEXA compared to a higher dose in preventing HSR. Method: A non-inferiority crossover randomized controlled trial was conducted. Patients aged 18 years or older receiving docetaxel-based chemotherapy were included, excluding those on concurrent steroid use or with diabetes mellitus. Patients received either a high dose of DEXA (16 mg/day) from the day before docetaxel infusion until …
Sensitivity And Specificity Of Nanopore Sequencing For Detection Of Methicillin-Resistant Staphylococcus Aureus And Methicillin-Resistant Staphylococcus Epidermidis In Blood Culture Sample, Onjira Mangkalamanee
Sensitivity And Specificity Of Nanopore Sequencing For Detection Of Methicillin-Resistant Staphylococcus Aureus And Methicillin-Resistant Staphylococcus Epidermidis In Blood Culture Sample, Onjira Mangkalamanee
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Nanopore sequencing enables rapid DNA/RNA analysis without amplification. Implementing this for point-of-care testing reduces time delays in traditional AST methods, potentially enhancing patient outcomes. We aim to evaluate the performance of Oxford Nanopore Technologies sequencing from positive blood culture for bacterial identification and antimicrobial susceptibility prediction in S. aureus and S. epidermidis by detecting the mecA gene. Methods: We conducted a cross-sectional descriptive study on individuals with positive blood cultures identifying S. aureus and S. epidermidis over a 12-month period from April 2023 to March 2024. Bacterial DNA was extracted from the blood culture specimens, and then sequenced in …
Dosimetric Comparison Of Imrt, Co-Planar Vmat, Non-Coplanar Vmat And Hyperarc For Multiple Brain Metastases Srs, Aksarapak Thawornnittayakul
Dosimetric Comparison Of Imrt, Co-Planar Vmat, Non-Coplanar Vmat And Hyperarc For Multiple Brain Metastases Srs, Aksarapak Thawornnittayakul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Multiple brain metastases patients are typically treated by stereotactic radiosurgery (SRS) or whole brain radiation therapy (WBRT). In addition, there are advanced techniques for treating multiple brain metastases such as 3-dimensional Conformal Radiation Therapy (3D-CRT), Intensity Modulated Radiation Therapy (IMRT), and Volumetric Modulated Arc Therapy (VMAT). A new isocentric VMAT technique called HyperArc was developed for non-coplanar, it is an automated setting for couch angle and collimator angle. This study aims to compare the dosimetric effect for a single isocenter among Intensity Modulated Radiation Therapy, Volumetric Modulated Arc Therapy, and HyperArc for multiple brain metastases stereotactic radiosurgery. For 25 patients …