Digital Commons Network^™

Fairness For Transactional Events, Edward Amsden, Matthew Fluet

Articles

Transactional events are a recent concurrency abstraction that combines first-class synchronous message-passing events with all-or-nothing transactions. Transactional events provide both a sequencing combinator, which permits the description of behaviors in which multiple potential synchronization actions (including communications between threads) either all occur in sequence or none of them occur, and a nondeterministic choice combinator, which permits the description of behaviors in which exactly one of a set of potential synchronization actions occurs. While prior work gave a semantics and an implementation for transactional events, it provided no guarantees about which of the many non-deterministic executions might be exhibited by a …

Development And Validation Of A Novel Reporter Assay For Human Papillomavirus Type 16 Late Gene Expression, Beatrice Orru, Ciaran Cunniffe, Fergus Ryan, Stefan Schwartz

Articles

To facilitate the investigations of HPV-16 late gene expression HPV-16 reporter plasmids were generated using previously described sub-genomic HPV-16 plasmids, named pBEL and pBELM, that, similar to the full viral genome, produce primarily HPV-16 early mRNAs and very little, if any, late mRNAs in cervical cancer cells. The HPV-16 late L1 gene was replaced by the chloramphenicol acetyltransferase (CAT) reporter gene, or green fluorescent protein (GFP), preceded by the poliovirus internal ribosome entry site (IRES). Results show that the reporter genes mimic the expression of L1 from these plasmids. For example, overexpression of adenovirus E4orf4 protein (E4orf4), polypyrimidine tract binding …

Defects In Acute Rsponses To Tlr4 In Btk-Deficient Mice Result In Impaired Dendritic Cell-Induced Ifn-Γ Production By Natural Killer Cells, Joan Ní Gabhann, Shaun Spence, Claire Wynne, Siobhán Smith, Jennifer C. Byrne, Barbara Coffey, Kevin Stacey, Adrien Kissenpfennig, James A. Johnston, Caroline A. Jefferies

Articles

This study defines a critical role for Btk in regulating TLR4-induced crosstalk between antigen presenting cells (APCs) and natural killer (NK) cells. Reduced levels of IL-12, IL- 18 and IFN-γ were observed in Btk-deficient mice and ex vivo generated macrophages and dendritic cells (DCs) following acute LPS administration, whilst enhanced IL-10 production was observed. In addition, upregulation of activation markers and antigen presentation molecules on APCs was also impaired in the absence of Btk. APCs, by virtue of their ability to produce IL-12 and IL-18, are strong inducers of NK-derived IFN-γ. Co-culture experiments demonstrate that Btk-deficient DCs were unable to …

Bi-Lateral Changes To Hippocampal Cholesterol Levels During Epileptogenesis And In Chronic Epilepsy Following Focal-Onset Status Epilepticus In Mice, Steve Meaney, Maura Heverin, Tobias Engel, Eva Jimenez-Mateosa, Reza Al-Aaudia, David Henshall

Articles

Brain cholesterol homeostasis has been shown to be disrupted in neurodegenerative conditions such as Alzheimer's and Huntington's diseases. Investigations in animal models of seizure-induced brain injury suggest that brain cholesterol levels are altered by prolonged seizures (status epilepticus) and are a feature of the pathophysiology of temporal lobe epilepsy. The present study measured hippocampal sterol levels in a model of unilateral hippocampal injury triggered by focal-onset status epilepticus, and in chronically epileptic mice. Status epilepticus was induced by intra-amygdala microinjection of kainic acid and ipsilateral and contralateral hippocampus analyzed. No significant changes were found for ipsilateral or contralateral hippocampal levels …

Water At Room Temperature As A Solvent For The Extraction Of Apple Pomace Phenolic Compounds, Sofia Reis, Dilip Rai, Nissreen Abu-Ghannam

Articles

A fractionation method was used for the extraction of phenolic compounds from apple pomace (AP) involving a first extraction with water and subsequent extractions of the same residue with two different organic solvents. The water extracts obtained presented high amounts of phenolic compounds with high antioxidant capacity however, the second and third extractions of the same residue still extracted considerable amounts of remaining phenolic compounds with significant antioxidant capacities. Liquid chromatography – electrospray ionization mass spectrometry (LC-ESI/MS) studies showed water to be a good solvent to extract hydroxycinnamic acids, flavonols, flavanols, dihydrochalcones and flavones present in the AP. However, water …

Comparison Of Micro- And Nanoscale Fe+3-Containing (Hematite) Particles For Their Toxicological Properties In Human Lung Cells In Vitro, Kunal Bhattacharya, Eik Hoffmann, Roel Schins, Jens Boertz, Eva-Maria Prantl, Gerrit Alink, Hugh Byrne, Thomas Kuhlbusch, Qamar Rahman, Hartmut Wiggers, Christof Schulz, Elke Dopp

Articles

The specific properties of nanoscale particles, large surface-to-mass ratio and highly reactive surfaces, have increased their commercial application in many fields. However, the same properties are also important for the interaction and bio-accumulation of the non-/biodegradable nanoscale particles in a biological system and are a cause for concern. Hematite (α-Fe2O3), being a mineral form of Fe(III) oxide, is one of the most used iron oxides besides magnetite. The aim of our study was the characterization and comparison of biophysical reactivity and toxicological effects of α-Fe2O3 nano- (d < 100 nm) and microscale (d < 5 μm) particles in human lung cells. Our study demonstrates that the surface reactivity of nanoscale α-Fe2O3 differs to that of microscale particles with respect to the state of agglomeration, radical formation potential, and cellular toxicity. The presence of proteins in culture medium and agglomeration were found to affect the catalytic properties of the hematite nano- and microscale particles. Both the nano- and microscale α-Fe2O3 particles were actively taken up by human lung cells in vitro, although, they were not found in the nuclei and mitochondria. …

China’S ‘Attitude’ Toward Human Rights: Reading Hungdah Chiu In The Era Of The Iraq War, Dongsheng Zang

Articles

China observers in the United States generally share two observations on China today: that China has made impressive progress in economic development in the past three decades, and that China has maintained a poor human rights record since the 1989 Tiananmen Massacre. On the economic front, China overtook Japan and became the second largest economy in 2010. In a joint study with China's Development Research Center of the State Council, the World Bank recently predicted that even if the Chinese economy grows a third as slowly in the future, it will outstrip the United States in terms of overall GDP …

Taxing Facebook Code: Debugging The Tax Code And Software, Xuan-Thao Nguyen, Jeffrey A. Maine

Articles

This article sets out to analyze both intellectual property laws and tax systems as applied to computer software. It analyzes software within intellectual property's established doctrinal framework, a difficult task due to the fact that software can encompass some combination of the traits of copyrights, trade dress, patents, and trade secrets. It then examines both the federal and state tax systems governing software. It shows that fitting software within current tax schemes presents unique challenges, as software contains both tangible and intangible elements, is subject to varying intellectual property protections, and can be delivered through various media. The article argues …

Legal Ethics And Federal Taxes, 1945-1965: Patriotism, Duties, And Advice, Michael Hatfield

Articles

This article is devoted to exploring the legal ethics writings by tax lawyers in a pivotal period of income tax history: 1945-1965, the first two decades of the federal income tax as we now know it. Although the income tax began in 1913, it was World War II that created the modem mass income tax: in 1939 there were 3.9 million individual income tax taxpayers but by 1945 there were 42.6 million. This period was also one of significant progress in the administration of the income tax: the Internal Revenue Code was re-organized in 1954 and, following widespread corruption scandals, …

Negotiating Jurisdiction: Retroceding State Authority Over Indian Country Granted By Public Law 280, Robert T. Anderson

Articles

This Article canvasses the jurisdictional rules applicable in American Indian tribal territories-"Indian country." The focus is on a federal law passed in the 1950s, which granted some states a measure of jurisdiction over Indian country without tribal consent. The law is an aberration. Since the adoption of the Constitution, federal law preempted state authority over Indians in their territory. The federal law permitting some state jurisdiction, Public Law 280, is a relic of a policy repudiated by every President and Congress since 1970. States have authority to surrender, or retrocede, the authority granted by Public Law 280, but Indian tribal …

The Structural Exceptionalism Of Bankruptcy Administration, Rafael I. Pardo, Kathryn A. Watts

Articles

The current system of administration of the Bankruptcy Code is highly anomalous. It stands as one of the few major federal civil statutory regimes administered almost exclusively through adjudication in the courts—not through a federal regulatory agency. This means that rather than fitting bankruptcy into a regulatory model, the U.S. Congress has chosen to give the courts primary interpretive authority in the field of bankruptcy, delegating to courts the power to engage in residual policymaking.

Although scholars have noted some narrow aspects of the structural exceptionalism of bankruptcy administration, Congress’s decision to locate responsibility for bankruptcy policymaking almost exclusively with …

Fostering The Business Of Innovation: The Untold Story Of Bowers V. Baystate Technologies, Robert W. Gomulkiewicz

Articles

Perhaps the law review literature does not need another article on the Federal Circuit’s case [320 F.3d 1317 (Fed. Cir. 2003, cert denied, 123 S.Ct. 2588 (2003)]. That case has received more than its share of attention from commentators, all criticizing Judge Rader’s majority opinion and most extolling the virtues of Judge Dyk’s dissent. Despite the storm of scholarly criticism, however, courts have followed Judge Rader’s opinion.

This Article tells the untold story of why courts have been wise to do so. The Article explains how commentators have argued that federal intellectual property law should have preempted Bowers’ claims …

Proving Corporate Criminal Liability For Negligence In Vessel Management And Operations: An Allision-Oil Spill Case Study, Craig H. Allen

Articles

Maritime policy analysts often invoke the "vessel safety net" metaphor to explain the independent, but overlapping, risk management roles and responsibilities of the vessel master and crew, owner and charterer, operating company, classification society, flag state and port states. Oil spills from the 2002 M/T Prestige break up off the coast of Galicia, Spain, the 2007 M/V Cosco Busan bridge allision in San Francisco Bay and the 2010 Deepwater Horizon debacle in the Gulf of Mexico, among others, demonstrate that any or all of the components of that safety net may come under scrutiny following a marine casualty, possibly leading …

Giving Voice To Rachel Carson: Putting Science Into Environmental Law, William H. Rodgers, Jr.

Articles

Certainly, the most pressing issue of modern times is to develop a body of environmental law (that includes climate change) that is highly responsive to science. Without demeaning the many distinctions between the exercise of science and the practice of law, let me cut to the chase and declare that science is mostly about the “pursuit of truth” and law is mostly about “who wins.” Anybody who doubts this proposition should examine the radical differences between the “Supreme Court of Science” in the United States and the Supreme Court of Law.

The Supreme Court of Science, the National Research Council, …

Serious Flaw Of Employee Invention Ownership Under The Bayh-Dole Act In Stanford V. Roche: Finding The Missing Piece Of The Puzzle In The German Employee Invention Act, Toshiko Takenaka

Articles

This article argues that the current Bayh-Dole Act is incomplete because the Act fails to provide a mechanism for contractors to secure the ownership of federally funded inventions from their employees. Part I of this Article discusses this flaw in the current Bayh-Dole Act, highlighted by Stanford v. Roche, and argues that a historical accident resulted in this flaw due to Congress's failure to pass a series of bills based on the German EIA. Passages in the Bayh-Dole Act suggest that the Act assumes a transfer by operation of law to secure the ownership of federally funded inventions through …

Concrete Private Interest In Regulatory Enforcement: Tradable Environmental Resource Rights As A Basis For Standing, Danieli Evans

Articles

This Note proposes a novel solution to standing problems faced by environmental plaintifs seeking to enforce, or to compel agencies to enforce, environmental regulation. It argues that environmental plaintifs should be able to obtain standing to bring an Administrative Procedure Act (APA) review action or a citizen suit based on ownership of private tradable environmental resource rights, created by increasingly popular environmental privatization programs. These rights should operate as a basis for standing even for plaintifs who would otherwise be unable to meet standing requirements of individual injury, causation, and redressability. Relying on tradable rights to environmental resources as a …

Irish Education And The Financial Crisis, Deirdre Lillis, John Morgan

Articles

Regardless of economic fortunes, investment in education remains a constant in terms of its perceived value to Ireland and it is seen as critical to the economic recovery of the country. Ireland has one of the highest educational participation rates in the world, is considered to have the ‘most employable’ graduates in Europe and produces more graduates per 1000 inhabitants than any other European country. The degree to which the financial crisis has impacted Irish education is explored here.

Evaluating The Benefits Of Octree-Based Indexing For Lidar Data, Abu Saleh Mohammad Mosa, Bianca Schoen-Phelan, Michela Bertolotto, Debra Laefer

Articles

Very large true three-dimensional (3D) point datasets, as opposed to the previously common 2.5D data sets, are progressively more common nowadays, such as from Light Detection and Ranging (LiDAR). Increasingly, attempts are made to exploit these 3D point data sets beyond mere visualization. However, current Spatial Information Systems provide only limited 3D support. Even commercial systems advertising in-built, 3D data types provide only minimal functionality. Particularly, there is no effective means of indexing large 3D point datasets, which is crucial for efficient analysis and engineering usage. Also many datasets are information rich (e.g. contain color or some other associated semantic …

Analogues Of The Epoxy Resin Monomer Diglycidyl Ether Of Bisphenol F: Effects On Contact Allergenic Potency And Cytotoxicity, Niamh O'Boyle, Tamara Delaine, Kristina Luthman, Andreas Natsch, Ann-Therese Karlberg

Articles

Diglycidyl ethers of bisphenol A (DGEBA) and bisphenol F (DGEBF) are widely used as components in epoxy resin thermosetting products. They are known to cause occupational and non-occupational allergic contact dermatitis. The aim of this study is to investigate analogues of DGEBF with regard to contact allergy and cytotoxicity. A comprehensive knowledge of the structural features that contribute to the allergenic and cytotoxic effects of DGEBF will guide the development of future novel epoxy resin systems with reduced health hazards for those coming into contact with them. It was found that the allergenic effects of DGEBF were dependent on its …

Synthesis, Characterisation And Photo-Stability Of A Folate-Modified Β-Cyclodextrin As A Functional Food Additive., Zlata Tofzikovskaya, Christine O'Connor, Mary Mcnamara

Articles

A novel two-step synthetic route was developed and gave the mono-substituted derivative 6-deoxy-6-[(1-(2-amino)ethylamino)folate]-b-cyclodextrin (CDEnFA) with high yield (60 %). Elemental analysis, mass spectrometry, ¹H and ¹³C NMR, FTIR and Raman spectroscopies demonstrated the successful synthesis of the γ isomer only with no evidence of the presence of other isomers or free folic acid. Electronic absorption spectroscopy was used to study the photochemical properties of CDEnFA and showed that in both the solid state and aqueous solution CDEnFA is considerably more photo-stable than free folic acid.

On Projection-Invariant Subgroups Of Abelian P-Groups, Brendan Goldsmith

Articles

A subgroup P of an Abelian p-group G is said to be projection-invariant in G if Pf is contained in P for all idempotent endomorphisms f. Clearly fully invariant subgroups are projection invariant, but the converse is not true in general. Hausen and Megibben have shown that in many familiar situations these two concepts coincide. In a different direction, the authors have previously introduced the notions of socle-regular and strongly socle-regular groups by focussing on the socles of fully invariant and characteristic subgroups of p-groups. In the present work the authors examine the socles of projection-invariant subgroups of Abelian p-groups.

The Generalised Zakharov-Shabat System And The Gauge Group Action, Georgi Grahovski

Articles

The generalized Zakharov–Shabat systems with complex-valued non-regular Cartan elements and the systems studied by Caudrey, Beals and Coifman (CBC systems) and their gauge equivalent are studied. This study includes: the properties of fundamental analytical solutions (FAS) for the gauge-equivalent to CBC systems and the minimal set of scattering data; the description of the class of nonlinear evolutionary equations, solvable by the inverse scattering method, and the recursion operator, related to such systems; the hierarchies of Hamiltonian structures. The results are illustrated on the example of the multi-component nonlinear Schr¨odinger (MNLS) equations and the corresponding gauge-equivalent multi-component Heisenberg ferromagnetic (MHF) type …

The Emerging Role Of Acyl-Coa Thioesterases And Acyltransferases In Regulating Peroxisomal Lipid Metabolism, Mary Hunt, Marina Siponen, Stefan Alexson

Articles

The importance of peroxisomes in lipid metabolism is now well established and peroxisomes contain approximately 60 enzymes involved in these lipid metabolic pathways. Several acyl-CoA thioesterase enzymes (ACOTs) have been identified in peroxisomes that catalyze the hydrolysis of acyl-CoAs (short-, medium-, long- and very long-chain), bile acid-CoAs, and methyl branched-CoAs, to the free fatty acid and coenzyme A. A number of acyltransferase enzymes, which are structurally and functionally related to ACOTs, have also been identified in peroxisomes, which conjugate (or amidate) bile acid-CoAs and acyl-CoAs to amino acids, resulting in the production of amidated bile acids and fatty acids. The …

Computation Of The Stochastic Volatility And Levy Index Using The Kolmogorov-Feller Equation With Applications To Carbon Price Data Analysis, Jonathan Blackledge, Marc Lamphiere, Afshin Panahi

Articles

We derive new algorithms for computing time variations in the Stochastic Volatility and the L´evy index using a standard financial price model and a Green’s function solution to the Kolmogorov-Feller equation. A principal condition upon which the algorithms are based is the Phase Only Condition which allows the Power Spectral Density Function of a financial time series (specifically the log price differences) to be taken to be a constant. The paper is composed of four component parts: (i) the Stochastic Volatility is derived and studied numerically; (ii) the Kolmogorov-Feller equation is studied and solved to provide a model for the …

Development And Evaluation Of A Desktop Vr System For Electrical Services Engineers, Martin Barrett, Jonathan Blackledge

Articles

This paper presents a prototype desktop virtual reality model, developed to enhance electrical safety and design in the built environment. The model presented has the potential to be used as an educational tool for third level students, an industry design tool or as a virtual electrical safety manual for the general public. A description of the development of the virtual reality model is presented along with the applications that were developed within the model. Subsequently, a case study is carried out to evaluate the users’ attitudes toward VR learning environments and also the usability of the prototype model developed. Based …

Stochastic Volatility Analysis Using The Generalised Kolmogorov-Feller Equation, Jonathan Blackledge, Marc Lamphiere, Kieran Murphy, Shaun Overton, Afshin Panahi

Articles

We consider an approach to analysing the Stochastic Volatility of a financial time series using the Generalised Kolmogorov-Feller Equation (GKFE). After reviewing the computation of the Stochastic Volatility using a phase only condition, a Green’s function solution to the GKFE equation is derived which depends upon the ‘memory function’ used to construct the GKFE. Using the Mittag-Leffler memory function, we derive an expression for the Impulse Response Function associated with a short time window of data which is then used to derive an algorithm for computing a new index using a standard moving window process. It is shown that application …

Simulation And Analysis Of Stochastic Signals Using The Kolmogorov-Feller Equation, Jonathan Blackledge, Marc Lamphiere, Kieran Murphy, Shaun Overton, Afshin Panahi

Articles

We consider a Green's function solution to the Classical Kolmogorov- Feller Equation which requires an iterative approach for which a sufficient convergence condition is derived. The solution obtained is applied to the simulation of signals whose spectral properties are determined by a Characteristic Function of the form j k j��q; q > 0 where k is the spatial frequency and q is the 'Fourier Dimension'. Using example macroeconomic financial time series (FTSE Close-of-Day and the Dow Jones Industrial Average), correlations are observed to exist between q and long term trends in the series using a standard moving window process. This result …

Analysis Of Wind Velocity Signals For Estimating The Wave Power Density Of Ireland's Coastal Resource, Jonathan Blackledge, Eugene Dermot Coyle Professor, Derek Kearney, Ronan Mcguirk

Articles

The aim of this paper is to report on a possible correlation between the Lévy index for the wind velocity and the mean Energy Density of sea surface waves in the same location. The result is based on data obtained from six buoys located around the coast of Ireland and maintained by the Marine Institute of Ireland. These buoys provide signals on the wind velocity, wave height and wave period as well as other data on an hourly interval. Using this data, we consider the relationship between a stochastic model for the time variations in wave height that, in turn, …

Evaluation Of A Prototype Desktop Virtual Reality Model Developed To Enhance Electrical Safety And Design In The Built Environment, Martin Barrett, Jonathan Blackledge

Articles

The use of Desktop Virtual Reality (VR) systems for enhancing electrical safety and engineering design is a novel prospect for both practicing and student electrical services engineers. This innovative approach, which can be readily accessed via the World Wide Web, constitutes a marked shift in conventional learning and design techniques to a more immersive, interactive and intuitive working and learning environment. This paper initially identifies the unique characteristics of desktop web based VR technologies and highlights the educational affordances offered by working in such an environment. Subsequently, using a prototype model titled ‘Virtual Electrical Services’, a case study is carried …

A Teaching Practice Review Of The Use Of Multiple-Choice Questions For Formative And Summative Assessment Of Student Work On Advanced Undergraduate And Postgraduate Modules In Engineering, Aidan O'Dwyer

Articles

This paper reflects on, reports on and evaluates the use of multiple-choice questions, in both formative and summative assessment modes, on control engineering modules taken by advanced undergraduate and postgraduate engineering students, over four academic years. The material covered by the modules is analytical in nature. The rationale for examining the assessment strategy was the poor performance by students in a closed book traditional terminal examination on one of the advanced undergraduate modules over some years. The change in assessment strategy has improved student learning, as measured by assessment data; student feedback on the assessment methods is broadly positive. The …