Digital Commons Network^™

Ireland's Tidal Energy Resource: An Assessment Of A Site In The Bulls Mouth And The Shannon Estuary Using Measured Data, Fergal O'Rourke, Fergal Boyle, Anthony Reynolds

Articles

The issues associated with Ireland’s over reliance on fossil fuels to meet energy demands have sparked an interest in renewable energy. Renewable energy resources typically are intermittent and vary significantly in energy intensity. Tidal energy however has the advantage of predictability over large time scales and high power densities. A study of Ireland's tidal-current-energy resource has identified several viable sites. As part of this resource assessment, Acoustic Doppler Current Profilers were installed at two locations along Ireland's west coast, at a site in the Bulls Mouth and the Shannon Estuary. The Acoustic Doppler Current Profilers measured tidal current speed and …

A Quantitative Analysis Of The Impact Of Wind Energy Penetration On Electricity Prices In Ireland, Micheal O'Flaherty, Niall Riordan, Noel O'Neill, Ciara Ahern

Articles

The maturity of wind technology combined with availability of suitable sites means Ireland is on course to generate 40% of its electricity from the wind by 2020.This work sets out to quantify, to what degree, if any, increased wind penetration translates into reduced wholesale and retail prices for electricity. The consensus from the literature is that increasing wind penetration reduces wholesale electricity prices, but views vary as to what degree this translates into reduced retail prices for the consumer.

This work demonstrates the effect of wind energy penetration on the price of electricity in Ireland using quantitative data from the …

Cmos-Compatible 2-Bit Optical Spectral Quantization Scheme Using A Silicon-Nanocrystal-Based Horizontal Slot Waveguide, Zhe Khang, Jinhui Yuan, Gerald Farrell, Chongxiu Yu, Feng Li, Hwa Yaw Tam, P. K.A. Wai

Articles

All-optical analog-to-digital converters based on the third-order nonlinear effects in silicon waveguide are a promising candidate to overcome the limitation of electronic devices and are suitable for photonic integration. In this paper, a 2-bit optical spectral quantization scheme for on-chip all-optical analog-to-digital conversion is proposed. The proposed scheme is realized by filtering the broadened and split spectrum induced by the self-phase modulation effect in a silicon horizontal slot waveguide filled with silicon-nanocrystal. Nonlinear coefficient as high as 8708 W21 /m is obtained because of the tight mode confinement of the horizontal slot waveguide and the high nonlinear refractive index of …

Enhanced Broadband Parametric Wavelength Conversion In Silicon Waveguide With The Multi-Period Grating, Xianting Zhang, Jinhui Yuan, Jiaziu Zou, Boyuan Jin, Xinzhu Sang, Qiang Wu, Chongxiu Yu, Gerald Farrell

Articles

No abstract provided.

A Review Of Psychometric Data Analysis And Applications In Modelling Of Academic Achievement In Tertiary Education, Geraldine Gray, Colm Mcguinness, Philip Owende, Aiden Carthy

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Increasing college participation rates, and diversity in student population, is posing a challenge to colleges in their attempts to facilitate learners achieve their full academic potential. Learning analytics is an evolving discipline with capability for educational data analysis that could enable better understanding of learning process, and therefore mitigate these challenges. The outcome from such data analysis will be dependent on the range, type, and quality of available data and the type of analysis performed. This study reviewed factors that could be used to predict academic performance, but which are currently not systematically measured in tertiary education. It focused on …

Comparison Of Semi-Automated And Manual Measurements Of Carotid Intima-Media Thickening, Oscar Mac Ananey, G Mellotte, V Maher

Articles

Carotid intima-media thickening (CIMT) is a marker of both arteriosclerotic and atherosclerotic risks. Technological advances have semiautomated CIMT image acquisition and quantification. Studies comparing manual and automated methods have yielded conflicting results possibly due to plaque inclusion in measurements. Low atherosclerotic risk subjects (n = 126) were recruited to minimise the effect of focal atherosclerotic lesions on CIMT variability. CIMT was assessed by high-resolution B-mode ultrasound (Philips HDX7E, Phillips, UK) images of the common carotid artery using both manual and semiautomated methods (QLAB, Phillips, UK). Intraclass correlation coefficient (ICC) and the mean differences of paired measurements (Bland-Altman method) were used …

Increased Expression Of Phosphorylated Fadd In Anaplastic Large Cell And Other T-Cell Lymphomas, Suketu Patel, Derek Murphy, Eugenia Haralambieva, Zainalabideen A. Abdulla, Kah Keng Wong, Hong Chen, Edith Gould, Giovanna Roncador, Chris S.R. Hatton, Amanda P. Anderson, Alison H. Banham, Karen Pulford

Articles

FAS-associated protein with death domain (FADD) is a major adaptor protein involved in extrinsic apoptosis, embryogenesis, and lymphocyte homeostasis. Although abnormalities of the FADD/death receptor apoptotic pathways have been established in tumorigenesis, fewer studies have analyzed the expression and role of phosphorylated FADD (pFADD). Our identification of FADD as a lymphoma-associated autoantigen in T-cell lymphoma patients raises the possibility that pFADD, with its correlation with cell cycle, may possess role(s) in human T-cell lymphoma development. This immunohistochemical study investigated pFADD protein expression in a range of normal tissues and lymphomas, particularly T-cell lymphomas that require improved therapies. Whereas pFADD was …

Btk Regulated Macrophage Polarization In Response To Lipopolysaccharide, Joan Ní Gabhann, Emily Hams, Siobhán Smith, Claire Wynne, Jennifer C. Byrne, Kiva Brennan, Shaun Spence, Adrien Kissenpfennig

Articles

Bacterial Lipopolysaccharide (LPS) is a strong inducer of inflammation and does so by inducing polarization of macrophages to the classic inflammatory M1 population. Given the role of Btk as a critical signal transducer downstream of TLR4, we investigated its role in M1/M2 induction. In Btk deficient (Btk^−\−) mice we observed markedly reduced recruitment of M1 macrophages following intraperitoneal administration of LPS. Ex vivo analysis demonstrated an impaired ability of Btk^−/− macrophages to polarize into M1 macrophages, instead showing enhanced induction of immunosuppressive M2-associated markers in response to M1 polarizing stimuli, a finding accompanied by reduced phosphorylation …

Pilot Data On Brain-To-Blood Efflux Of B-Amyloid Peptides In Man, Steve Meaney, Maura Heverin, Ingemar Bjorkhem,, Dorotea Religa, John Wahren, Ulf Diczfalusy

Articles

• Alzheimer’s disease (AD) is the most common cause of dementia and affects nearly 40,000 individuals in Ireland. • The b-amyloid peptide (Ab) plays a key role in the pathogenesis of the AD and the presence of Ab plaques in the brain is diagnostic. •The hypothesis posits that Ab deposition is a critical factor in the disease process and that production and clearance of Ab are key drivers of the disease1. •Flux of Ab from the brain is believed to contribute to the overall level of Ab within in brain2 and antibody mediated brain-to-blood efflux has been observed in animal …

Ethnic Variation In Breastfeeding And Complementary Feeding In The Republic Of Ireland, Patricia Castro, Richard Layte, John Kearney

Articles

Early nutrition plays a pivotal role in long-term health. The World Health Organization (WHO) recommends exclusive breastfeeding during the first six months of life, with the gradual introduction of solids after this period. However, studies in the Republic of Ireland (ROI) have shown poor compliance with guidelines. The ROI continues to have one of the lowest breastfeeding rates worldwide. Our objective was to analyse differences in breastfeeding and complimentary feeding behaviours between Irish and non-Irish mothers residing in the ROI, as well as the role of acculturation on these behaviours, using the national longitudinal study, Growing Up in Ireland (GUI). …

Trim68 Negatively Regulates Ifn-B Production By Degrading Trk Fused Gene, A Novel Driver Of Ifn-B Downstream Of Anti-Viral Detection Systems, Claire Wynne, Elisa Lazzari, Siobhan Smith, Eoghan Mccarthy, Joan Ni Gabhann, Lara Kallai, Rowan Higgs, Sally Ann Cryan, Christine Byron, Caroline Jefferies

Articles

In recent years members of the tripartite motif-containing (TRIM) family of E3 ubiquitin ligases have been shown to both positively and negatively regulate viral defence and as such are emerging as compelling targets for modulating the anti-viral immune response. In this study we identify TRIM68, a close homologue of TRIM21, as a novel regulator of Toll-like receptor (TLR)- and RIG-I-like receptor (RLR)-driven type I IFN production. Proteomic analysis of TRIM68-containing complexes identified TRK-fused gene (TFG) as a potential TRIM68 target. Overexpression of TRIM68 and TFG confirmed their ability to associate, with TLR3 stimulation appearing to enhance the interaction. TFG is …

Getting Started With Research " Beginning: Defining A Research Question And Preparing A Research Plan, Jacinta Browne

Articles

Research is the lifeblood of medicine with innovations being made in the different technologies used to diagnose and / or screen for the presence of disease or to deliver treatments with higher efficacy. Scientific publication is the network of vessels which delivers the lifeblood. The outputs of research provides us with tomorrows medicine. In this series of articles we will be discussing the different aspects of carrying out research from the conception of the research idea to publication in a peer reviewed journal with the cycle repeating again with new research ideas emerging from the research conducted.

Getting Started With Research " Writing-Up The Results Of Your Research", Jacinta Browne

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This paper gives an overview of the considerations and practical aspects of writing-up the results of your research which may be of interest to those beginning their research career or simply carrying out a research project for the first time as part of an academic qualification. It outlines practical steps for both writing-up the results of your research as an academic report and thereafter disseminating your results more widely as a peer-reviewed scientific publication.

Getting Started With Research "Carrying Out Your Research Project", Jacinta Browne

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This paper gives an overview of the considerations and practical aspects of carrying out a research project which may be of use to those beginning their research career or simply carrying out a research project for the first time as part of an academic qualification. It outlines practical steps for consideration in the day to day management of a research project and highlights areas which require particular consideration for a project to be completed successfully.

Investigation Of The Sensitivity To Humidity Of An Acrylamide-Based Photopolymer Containing N-Phenylglycine As A Photoinitiator, Tatsiana Mikulchyk, Suzanne Martin, Izabela Naydenova

Articles

Sensitivity of holographic recording materials to the relative humidity (RH) of the environment often restricts their use in fabrication of holographic optical elements and other applications. It is important to develop materials with little or no sensitivity to humidity. In this paper the humidity response of transmission gratings recorded in an acrylamide-based photopolymer containing N-phenylglycine (NPG) as a photoinitiator is studied at RH = 20 – 90 %. The hologram is found to be completely insensitive to humidity at RH below 70 % and its diffraction efficiency remains constant. A decrease in diffraction efficiency is observed at RH = 80 …

Holographic Sensors: Three-Dimensional Analyte-Sensitive Nanostructures And Their Applications, Ali K. Yetisen, Izabela Naydenova, Fernando Da Cruz Vasconcellos, Jeffrey Blyth, Christopher R. R. Lowe

Articles

Holographic sensors are analytical devices that systematically diffract narrow-band light in the ultraviolet to near-infrared range for application in the detection and quantification of analytes and/or physical parameters. They can be functionalized with analyte-responsive materials to construct highly sensitive optical sensors for use in testing, where a visual readout, fast turnaround time, and reversibility are needed. Holography allows fabrication of disposable sensors that are lightweight for miniaturization and multiplexing purposes.3 Holographic sensors offer three capabilities on a single analytical device: (i) label-free analyte-responsive polymer, (ii) real-time, reversible quantification of the external stimuli, and (iii) three-dimensional visual image display.

Socioeconomic Differentials In The Immediate Mortality Effects Of The National Irish Smoking Ban, Patrick J. Goodman, Sericea Stallings-Smith, Ariana Zeka, Z. Kabir, Luke Clancy

Articles

Background: Consistent evidence has demonstrated that smoking ban policies save lives, but impacts on health inequalities are uncertain as few studies have assessed post-ban effects by socioeconomic status (SES) and findings have been inconsistent. The aim of this study was to assess the effects of the national Irish smoking ban on ischemic heart disease (IHD), stroke, and chronic obstructive pulmonary disease (COPD) mortality by discrete and composite SES indicators to determine impacts on inequalities. Methods: Census data were used to assign frequencies of structural and material SES indicators to 34 local authorities across Ireland with a 2000–2010 study period. Discrete …

An Audit Of A Hospital-Based Doppler Ultrasound Quality Control Protocol Using A Commercial String Doppler Phantom, S. Cournane, Andrew Fagan, Jacinta Browne

Articles

Results from a four-year audit of a Doppler quality assurance (QA) program using a commercially available Doppler string phantom are presented. The suitability of the phantom was firstly determined and modifications were made to improve the reliability and quality of the measurements. QA of Doppler ultrasound equipment is very important as data obtained from these systems is used in patient management. It was found that if the braided-silk filament of the Doppler phantom was exchanged with an O-ring rubber filament and the velocity range below 50cm/s was avoided for Doppler quality control (QC) measurements, then the Maximum Velocity Accuracy (MVA) …

The Utility Of Deformable Image Registration For Small Artery Visualisation In Contrast-Enhanced Whole Body Mr Angiography, Daniel Foley, Jacinta Browne, Xiahai Zhuang, Barry Sheane, Dearbhail O'Driscoll, Daniel Cannon, Niall Sheehy, James Meaney, Andrew Fagan

Articles

Purpose;

An investigation was carried out into the effect of three image registration techniques on the diagnostic image quality of contrast-enhanced magnetic resonance angiography (CE-MRA) images.

Methods Whole-body CE-MRA data from the lower legs of 27 patients recruited onto a study of asymptomatic atherosclerosis were processed using three deformable image registration algorithms. The resultant diagnostic image quality was evaluated qualitatively in a clinical evaluation by four expert observers, and quantitatively by measuring contrast-to-noise ratios and volumes of blood vessels, and assessing the techniques’ ability to correct for varying degrees of motion.

Results The first registration algorithm (‘AIR’) introduced significant stenosis-mimicking …

Reducing Visual Deficits Caused By Refractive Errors In School And Preschool Children: Results Of A Pilot School Program In The Andean Region Of Apurimac, Peru, Sergio Latorre-Arteaga, Diana Gil-Gonzalez, Olga Enciso, Aoife Phelan, Angel Garcia-Munoz, Johannes Kohler

Articles

Background

Refractive error is defined as the inability of the eye to bring parallel rays of light into focus on the retina, resulting in nearsightedness (myopia), farsightedness (Hyperopia) or astigmatism. Uncorrected refractive error in children is associated with increased morbidity and reduced educational opportunities. Vision screening (VS) is a method for identifying children with visual impairment or eye conditions likely to lead to visual impairment.

Objective

To analyze the utility of vision screening conducted by teachers and to contribute to a better estimation of the prevalence of childhood refractive errors in Apurimac, Peru.

Design

A pilot vision screening program in …

Economic Valuation Of The Mortality Benefits Of A Regulation On So2 In 20 European Cities, Olivier Chanel, Susann Henschel, Patrick J. Goodman, Antonis Analitis, Richard W. Atkinson, Alain Le Tertre, Ariana Zeka, Sylivia Medina

Articles

Background: Since the 1970s, legislation has led to progress in tackling several air pollutants. We quantify the annual monetary benefits resulting from reductions in mortality from the year 2000 onwards following the implementation of three European Commission regulations to reduce the sulphur content in liquid fuels for vehicles. Methods: We first compute premature deaths attributable to these implementations for 20 European cities in the Aphekom project by using a two-stage health impact assessment method. We then justify our choice to only consider mortality effects as short-term effects. We rely on European studies when selecting the central value of …

Acoustic Properties Of Concrete Panels With Crumb Rubber As A Fine Aggregate Replacement, Niall Holmes, Alex Browne, Christopher Montague

Articles

This paper presents the acoustic performance of small scale crumb rubber concrete (CRC) panels in terms of the sound absorbance and insulation at low (63, 125, 250 & 500 Hz) and high (1000, 2000, 4000 and 5000 Hz) frequencies. Acoustic tests were conducted with differing levels of fine aggregate replacement with crumb rubber (7.5 and 15%) with four different grades following freezing and heating. Analysis of the workability, compressive strength and density are also presented. The results found that CRC performed well in terms of sound absorbance particularly with higher proportions (15% here) and grades of crumb rubber. As an …

Longitudinal Shear Resistance Of Composite Slabs Containing Crumb Rubber In Concrete Toppings, Niall Holmes, Kevin Dunne, John O'Donnell

Articles

This paper investigates the behaviour and longitudinal shear capacity of metal deck composite slabs with the inclusion of crumb rubber in the concrete toppings. The ability of the slabs to act compositely is governed by the shear interaction between the concrete topping and the profiled steel deck. Results here show that crumb rubber concrete (CRC) improve the overall shear bond capacity between the steel deck and topping following an experimental study on full scale loading tests in accordance with Eurocode 4. The results confirm that composite slabs incorporating crumb rubber had no effect on the longitudinal shear resistance with similar …

A Review Of The Hl-93 Bridge Traffic Load Model Using An Extensive Wim Database, Cathal Leahy, Eugene J. Obrien, Bernard Enright, Donya Hajializadeh

Articles

HL-93, the current bridge traffic load model used in the United States, is examined here. Weigh-in-motion from 17 sites in 16 states, and containing 74 million truck records, is used to assess the level of consistency in the characteristic load effects implied by the HL-93 model. The load effects of bending moment and shear force are considered on single-lane and two-lane same-direction slab and girder bridges with a range of spans. It is found that the ratio of WIM-implied to HL-93 load effect varies considerably from one load effect to another. An alternative model is proposed which achieves improvements in …

Antimicrobial Properties Of Vertically Aligned Nano-Tubular Copper, Kafil Razeeb, Joanna Podporska-Carroll, Mamun Jamal, Maksudul Hassan, Michael Nolan, Declan Mccormack, Brid Quilty, Simon Newcombe, Suresh Pillai

Articles

In this work, the antimicrobial properties of vertically aligned nano-tubular Cu arrays (NT-Cu) fabricated via a template-based electrodeposition approach were investigated. The NT-Cu display good bactericidal activity against S.aureus and bacteriostatic properties against E.coli, S.sonnei, S.enterica and C.albicans. In contrast, Cu-foil electrodeposited from the same solution shows low biological activity against the same microorganisms. The antimicrobial activity of NT-Cu depends on both the type of microorganism and exposure time. After 6 hours of exposure, over 99.99% (log red = 4.43) of S.aureus population was inactivated, whereas, for E.coli, S.sonnei, S.enterica and C.albicans it was 97.8, 94.2, 89.9, and 90.3%, respectively.

New Insights Into The Mechanism Of Visible Light Photocatalysis, Suresh Pillai, Swagata Banerjee, Polycarpos Falaras, Kevin O'Shea, John A. Byrne, Dionysios D. Dionysiou

Articles

ABSTRACT: In recent years, the area of developing visible-lightactive photocatalysts based on titanium dioxide has been enormously investigated due to its wide range of applications in energy and environment related fields. Various strategies have been designed to efficiently utilize the solar radiation and to enhance the efficiency of photocatalytic processes. Building on the fundamental strategies to improve the visible light activity of TiO2-based photocatalysts, this Perspective aims to give an insight into many contemporary developments in the field of visible-light-active photocatalysis. Various examples of advanced TiO2 composites have been discussed in relation to their visible light induced photoconversion efficiency, dynamics …

Photocatalytic Activity Indicator Inks For Probing A Wide Range Of Surfaces, Suresh Pillai, Andrew Mills, James Hepburn, David Hazafy, Christopher O'Rourke, Nathan Wells, Josef Krysa, Michal Baudys, Martin Zlamal, Hana Bartkova, Claire E. Hill, Kim R. Winn, Morten E. Simonsen, Erik G. Sogaard, Swagata Banerjee, Rachel Fagan

Articles

Three photocatalyst inks based on the redox dyes, Resazurin (Rz), Basic Blue 66 (BB66) and Acid Violet 7 (AV7, are used to assess the photocatalytic activities of a variety of different materials, such as commercial paint, tiles and glass and laboratory made samples of sol-gel coated glass and paint, which collectively exhibit a wide range of activities that cannot currently be probed by any one of the existing ISO tests. Unlike the ISO tests, the ink tests are fast (typically < 10 min), simple to employ and inexpensive. Previous work indicates that the Rz ink test at least correlates linearly with other photocatalytic tests such as the photomineralisation of stearic acid. The average time to bleach 90% of the key RGB colour component of the ink (red for Rz and BB66 inks) and green for AV7 ink) is determined, ttb(90), for eight samples of each of the different materials tested. Five laboratories conducted the tests and the results revealed an average repeatability and reproducibility of: ca. 11% and ca 21%, respectively, which compare well with those reported for the current ISO tests. Additional work on commercial self-cleaning glass using an Rz ink showed that the change in the red component of the RGB image of the ink correlated linearly with that of the change of absorbance (at 608 nm) (as measured using UV/Vis spectroscopy) and the change in the a* component of the Lab colour analysis of the ink, as measured using diffuse reflectance spectroscopy. As a consequence, all three methods generate the same ttb(90). The advantages of the RGB digital image analysis method are discussed briefly.

The Association Of Cold Weather And All-Cause And Cause-Specific Mortality In The Island Of Ireland Between 1984 And 2007, Ariana Zeka, Stephen Browne, Helen Mcavoy, Patrick Goodman

Articles

Background: This study aimed to assess the relationship between cold temperature and daily mortality in the Republic of Ireland (ROI) and Northern Ireland (NI), and to explore any differences in the population responses between the two jurisdictions. Methods: A time-stratified case-crossover approach was used to examine this relationship in two adult national populations, between 1984 and 2007. Daily mortality risk was examined in association with exposure to daily maximum temperatures on the same day and up to 6 weeks preceding death, during the winter (December-February) and an extended cold period (October-March), using distributed lag models. Model stratification by age and …

Children’S Rights Online: Challenges, Dilemmas And Emerging Directions, Sonia Livingstone, Brian O'Neill

Articles

Although it is widely held that a more inclusive and trusted internet can support a competitive knowledge economy, a digitally skilled labour force, civic participation and a pluralistic media sector, governments and regulators have tended to avoid intervening directly to achieve these aims, believing that industry is best positioned to respond to the fast pace of change in information and communication technologies (ICT).This reflects a wider policy shift away from top-down government measures towards flexible, dispersed and indirect forms of governance, encompassing industry self-regulation as well as elements of cooperation or co-regulation with relevant state agencies.

The Role Of E-Portfolios In Finance Studies: A Cross-Country Study., Lucia Morales, Amparo Soler-Dominguez Dr., Valentina Tarkovska

Articles

This study explores the use of ePortfolios as an efficient assessment tool to support students pursuing a Business degree, where Finance is a major component. We conducted an analysis on the role of ePortfolios in Higher Education at Technological University Dublin (Republic of Ireland) and at Universitat Jaume I (Spain) for undergraduate studies. Our findings suggest that ePortfolios could be used to facilitate and enhance students self-regulated learning experiences where the role of the instructor is fundamental at early stages—to ensure that the learning process comply with basic academic standards—and diminishes as students become familiar with their course requirements, the …