Digital Commons Network^™

Altered Neurotransmission Prior To Cognitive Decline In Aβpp/Ps1 Mice, A Model Of Alzheimer's Disease, Kevin N. Hascup, Erin R. Hascup

Articles

Indirect evidence supports altered glutamate signaling with Alzheimer's disease, however, it is not known if glutamate neurotransmission is impacted prior to cognitive decline. We examined cognition and glutamate neurotransmission in 2-4 month AβPP/PS1, an Alzheimer's disease model, and age-matched control mice. There were no differences in learning and memory as assessed by Morris water maze. However, in vivo electrochemical measures of potassium-evoked glutamate release in the CA1, but not the CA3 or dentate, was significantly elevated in AβPP/PS1 mice. These data support changes in the glutamatergic system that precedes cognitive decline in a mouse model of Alzheimer's disease.

The Contribution Of Phonological Knowledge, Memory, And Language Background To Reading Comprehension In Deaf Populations, Elizabeth A. Hirshorn, Matthew W G Dye, Peter Hauser, Ted R. Supalla

Articles

While reading is challenging for many deaf individuals, some become proficient readers. Little is known about the component processes that support reading comprehension in these individuals. Speech-based phonological knowledge is one of the strongest predictors of reading comprehension in hearing individuals, yet its role in deaf readers is controversial. This could reflect the highly varied language backgrounds among deaf readers as well as the difficulty of disentangling the relative contribution of phonological versus orthographic knowledge of spoken language, in our case ‘English,’ in this population. Here we assessed the impact of language experience on reading comprehension in deaf readers by …

Ecological Perspectives And Children’S Use Of The Internet: Exploring Micro To Macro Level Analysis, Brian O'Neill

Articles

Age-old debates on children’s encounters with media technologies reveal a long, fractured and contentious tradition within communication and media studies. Despite the fact there have been studies of e ects of media use by children since the earliest days of broadcasting, the subject remains under-theorised, poorly represented in the literature and not widely understood in media policy debates. Old debates have intensi ed in relation to the study of children and the internet. Pitted between alarmist accounts of risks, excessive use and harmful e ects on the one hand and the many accounts about „digital natives” and the transformational power …

First Steps In Developing Cement-Based Batteries To Power Cathodic Protection Of Embedded Steel In Concrete, Niall Holmes, Aimee Byrne, Brian Norton

Articles

This paper presents the first steps in developing innovative cement-based batteries to power cathodic protection in reinforced concrete structures. Initial electrical outputs of 1.55V and 23mA have been found to be sufficient to polarise prescribed corrosion currents of 20mA per m2 of embedded steel. Cathodic protection is a well-developed and powerful technique to limit the effects of steel reinforcement corrosion. However, as it requires an electrical supply day and night, it is often powered by non-environmentally friendly diesel generators or connected to the electrical grid. This paper focuses on increasing the ionic conductivity of the solution in the cement pores, …

Energy Savings Across Eu Domestic Building Stock By Optimizing Hydraulic Distribution In Domestic Space Heating Systems, Ciara Ahern, Brian Norton

Articles

The objective of this work is to quantify the resultant savings across the EU from the optimization of existing system components in domestic space heating distribution systems to maintain comfort levels. Heat energy savings are shown to range from 1% to 19% depending on dwelling type, age, location and initial specific heat energy consumption.

Raman Micro-Spectroscopy For Rapid Screening Of Oral Squamous Cell Carcinoma, Luis Felipe Carvalho, Franck Bonnier, Kate O'Callaghan, Jeff O'Sullivan, Stephen Flint, Hugh Byrne, Fiona Lyng

Articles

Raman spectroscopy can provide a molecular-level fingerprint of the biochemical composition and structure of cells with excellent spatial resolution and could be useful to monitor changes in composition for dysplasia and early, non-invasive cancer diagnosis (carcinoma in situ), both ex-vivo and in vivo. In this study, we demonstrate this potential by collecting Raman spectra of nucleoli, nuclei and cytoplasm from oral epithelial cancer (SCC- 4) and dysplastic (pre-cancerous, DOK) cell lines and from normal oral epithelial primary cell cultures, in vitro, which were then analysed by principal component analysis (PCA) as a multivariate statistical method to discriminate the spectra. Results …

Investigation Into The Electromechanical Properties Of Dielectric Elastomers Subjected To Pre-Stressing, Liang Jiang, Tony Betts, David Kennedy, Stephen Jerrams

Articles

Dielectric elastomers (DEs) are being exploited for biological applications such as artificial blood pumps, biomi-metic grippers and biomimetic robots. Generally, polyacrylate and silicone rubber (SR)are the most widely use materials for fabricating DEsinterms of mixing with other polymers or compounding them with highly dielectric particles. Furthermore, pre-stretch offers an effective approach to increasing actuated strain and dielectric strength and eliminating pull-ininstability.

In Vitro Evaluation Of The Cytotoxicity Of A Folate-Modified Β-Cyclodextrin As A New Anti-Cancer Drug Delivery System, Zlata Tofzikovskaya, Alan Casey, Orla L. Howe, Christine O'Connor, Mary Mcnamara

Articles

Many chemotherapeutic drugs are therapeutically non-selective and do not distinguish between healthy cells and tumour cells which can result in severe side effects and toxicity. Drug delivery systems can be used to target specific cells and therefore may eliminate many of the side effects, increasing drug efficiency and efficacy, and controlling drug release. One possible strategy for targeted drug delivery is to use unique molecular markers such as folate receptors in cancer cells. In this work the cytotoxicity of a novel cyclodextrin-folate conjugate, 6-deoxy-6-[(1-(-2amino)ethylamino)folate-β-cyclodextrin (CDEnFA) was studied using the MTT assay and the MCF-7 (Breast), HeLa (Cervical), A549 (Lung cancer) …

Visqol: An Objective Speech Quality Model, Andrew Hines, J. Skoglund, A. C. Kokaram, N. Harte

Articles

This paper presents an objective speech quality model, ViSQOL, the Virtual Speech Quality Objective Listener. It is a signal-based, full-reference, intrusive metric that models human speech quality perception using a spectro-temporal measure of similarity between a reference and a test speech signal. The metric has been particularly designed to be robust for quality issues associated with Voice over IP (VoIP) transmission. This paper describes the algorithm and compares the quality predictions with the ITU-T standard metrics PESQ and POLQA for common problems in VoIP: clock drift, associated time warping, and playout delays. The results indicate that ViSQOL and POLQA significantly …

Knowledge Sharing In Organisations: A Bayesian Analysis Of The Role Of Reciprocity And Formal Structure, Alberto Caimo, Alessandro Lomi

Articles

We examine the conditions under which knowledge embedded in advice relations is likely to reach across intraorganizational boundaries and be shared between distant organizational members. We emphasize boundary-crossing relations because activities of knowledge transfer and sharing across subunit boundaries are systematically related to desirable organizational outcomes. Our main objective is to understand how organizational and social processes interact to sustain the transfer of knowledge carried by advice relations. Using original fieldwork and data that we have collected on members of the top management team in a multiunit industrial group, we show that knowledge embedded in task advice relations is unlikely …

Effects Of The 2002-2020 National Spatial Strategy (Nss) On Ireland's Settlement Growth, Its Cities And On Other Gateways And Hubs, Brian Hughes

Articles

No abstract provided.

Dit-Topcon Internship Experience, Audrey Martin, Abigail Iversen

Articles

The Technological University Dublin (DIT: http://www.dit.ie/) is one of the largest Higher Education Institutes in Ireland, with 20,000 students registered and over 2000 members of staff. It has been providing technological higher education for over one hundred and twenty years encompassing the full spectrum of Third Level programmes. During that time the Institute's alumni have played important roles in technical and scientific innovation, economic and social development and culture and education both in Ireland and internationally.

The CEO of Topcon Positioning Systems Inc., Ray O’Connor is a DIT School of Surveying alumnus and in October 2013 Ray visited his …

Thinking Outside The Box: Promoting Learning Through Emotional And Social Skills Development, Aiden Carthy, Sinead Mcgilloway

Articles

The European Qualifications Framework provides a useful insight into the kinds of outcomes and abiliti es that are promotedacross the EU. However, beyond arguably vague references to concepts such as ‘integrity’ and ‘autonomy’, this frameworkmakes no reference to the development of students’social and emotional competencies. Based on initial research findings inan Irish context, and when considered against the backdrop of a convincing literature on the importance of emotionalintelligence in academic attainment, there would appear to be considerable scope to modify this framework in order to accommodate more specific reference to the development of emotional and social skills. This paper addresses …

A Response To The Ipcc Fifth Assessment, Jessica Owley, Sarah J. Adams-Schoen, Deepa Badrinarayana,, Cinnamon Carlarne, Robin Kundis Craig, John C. Dernbach, Keith H. Hirokawa, Alexandra B. Klass, Katrina Fischer Kuh, Stephen R. Miller, Shannon Roesler, Jonathan Rosenbloom, Inara Scott, David Takacs

Articles

No abstract provided.

The Case For Categorical Nonenforcement, Leigh Osofsky

Articles

No abstract provided.

Commentary: Exploiting Mixed Speech, Caroline Mala Corbin

Articles

The Supreme Court has been taking advantage of mixed speech—that is, speech that is both private and governmental—to characterize challenged speech in a way that ultimately permits the government to sponsor Christian speech. In Pleasant Grove City v. Summum, a free speech case where the government accepted a Christian Ten Commandments monument but rejected a Summum Seven Aphorisms monument, the Court held that privately donated monuments displayed in public parks were government speech as opposed to private speech and therefore not subject to free speech limits on viewpoint discrimination. In Town of Greece v. Galloway, an establishment case …

Speech Or Conduct? The Free Speech Claims Of Wedding Vendors, Caroline Mala Corbin

Articles

No abstract provided.

Corporate Religious Liberty, Caroline Mala Corbin

Articles

No abstract provided.

Self-Defense Against Robots And Drones, A. Michael Froomkin, P. Zak Colangelo

Articles

Robots can pose-or can appear to pose-a threat to life, property, and privacy. May a landowner legally shoot down a trespassing drone? Can she hold a trespassing autonomous car as security against damage done or further torts? Is the fear that a drone may be operated by a paparazzo or Peeping Tom sufficient grounds to disable or interfere with it? How hard may you shove if the office robot rolls over your foot? This Article addresses all those issues and one more. what rules and standards we could put into place to make the resolution of those questions easier and …

Dark Money In Motion: Mapping Issues Along The Money Trail, Frances R. Hill

Articles

No abstract provided.

From Anonymity To Identification, A. Michael Froomkin

Articles

This article examines whether anonymity online has a future. In the early days of the Internet, strong cryptography, anonymous remailers, and a relative lack of surveillance created an environment conducive to anonymous communication. Today, the outlook for online anonymity is poor. Several forces combine against it: ideologies that hold that anonymity is dangerous, or that identifying evil-doers is more important than ensuring a safe mechanism for unpopular speech; the profitability of identification in commerce; government surveillance; the influence of intellectual property interests and in requiring hardware and other tools that enforce identification; and the law at both national and supranational …

Representing Interdisciplinarity, Kunal Parker

Articles

No abstract provided.

Recklessness As A State Of Mind In 10(B) Cases: The Civil-Criminal Dialectic, Patricia S. Abril, Ann M. Olazabal

Articles

No abstract provided.

Adapting Conservation Easements To Climate Change, Adena R. Rissman, Jessica Owley, M. Rebecca Shaw, Barton (Buzz) Thompson

Articles

No abstract provided.

Regulating Mass Surveillance As Privacy Pollution: Learning From Environmental Impact Statements, A. Michael Froomkin

Articles

Encroachments on privacy through mass surveillance greatly resemble the pollution crisis in that they can be understood as imposing an externality on the surveilled. This Article argues that this resemblance also suggests a solution: requiring those conducting mass surveillance in and through public spaces to disclose their plans publicly via an updated form of environmental impact statement, thus requiring an impact analysis and triggering a more informed public conversation about privacy. The Article first explains how mass surveillance is polluting public privacy and surveys the limited and inadequate doctrinal tools available to respond to mass surveillance technologies. Then, it provides …

Identity And Narrative: Turning Oppression Into Client Empowerment In Social Security Disability Cases, Jonel Newman

Articles

No abstract provided.

Buying Teams, Andres Sawicki

Articles

No abstract provided.

Latcrit Praxis @ Xx: Toward Equal Justice In Law, Education And Society, Tayyab Mahmud, Athena Mutua, Francisco Valdes

Articles

No abstract provided.

Disclosing Disclosure's Defects: Addressing Corporate Irresponsibility For Human Rights Impacts, Marcia Narine

Articles

Although many people believe that the role of business is to maximize shareholder value, corporate executives and board members can no longer ignore their companies' human rights impacts on other stakeholders. Over the past four years, the role and responsibility of non-state actors such as multinationals has come under increased scrutiny. In 2011, the United Nations Human Rights Council unanimously endorsed the "UN Guiding Principles on Business and Human Rights," which outline the State duty to protect human rights, the corporate responsibility to respect human rights, and both the State and corporations' duties to provide remedies to parties. The Guiding …

Clear And Simple Deportation Rules For Crimes: Why We Need Them And Why It's Hard To Get Them, Rebecca Sharpless

Articles

In Padilla v. Kentucky, the U.S. Supreme Court held that defense attorneys have a Sixth Amendment duty to advise noncitizen clients of the "clear" immigration consequences of a proposed plea agreement. This Article argues that the Court's reference to clarity denotes predictability, not simplicity, and that defense attorneys must advise their clients of predictable immigration consequences, even if they are difficult to ascertain. The scope of this duty has broadened as the U.S. Supreme Court has made the crime-related deportation rules more determinate, although many rules remain complex. A legislative move to a regime of simple deportation rules would …