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1,10-Phenanthroline-5,6-Dione-Based Compounds Are Effective In Disturbing Crucial Physiological Events Of Phialophora Verrucosa, Marcela Queiroz Granato, Diego De Souza Goncalves, Sergio Henrique Seabra, Malachy Mccann, Michael Devereux, Andre Luis De Souza Dos Santos, Lucimar Ferreira Kneipp

Articles

Phialophora verrucosa is a dematiaceous fungus able to cause chromoblastomycosis, phaeohyphomycosis and mycetoma. All these fungal diseases are extremely difficult to treat and often refractory to the current therapeutic approaches. Therefore, there is an urgent necessity to develop new antifungal agents to combat these mycoses. In this context, the aim of the present work was to investigate the effect of 1,10-phenanthroline-5,6-dione (phendione) and its metal-based derivatives [Ag(phendione)2]ClO4 = ([Ag(phendione)2]+) and [Cu(phendione)3](ClO4)2.4H2O = ([Cu(phendione)3]2+) on crucial physiological events of P. verrucosa conidial cells. Using the CLSI protocol, we have shown that phendione, [Ag(phendione)2]+ and [Cu(phendione)3]2+ were able to inhibit fungal proliferation, …

Pilot Evaluation Of An Online Weight Management Programme, Shona Cawley, S. Farrell, D. G. Byrne, M. J. Turner, B. Clune, Daniel Mccartney

Articles

This intervention examined the efficacy of a six-week online weight loss programme. Student and staff of a third level institution (n=183) were recruited to the programme which provided individualised dietary advice for weight loss. Eighty-five participants (mean age 29.7 years, mean BMI 28.9kg/m2, 33% male) met the minimum inclusion criterion of logging on to the study website at least twice.

Controlled Cytotoxicity Of Plasma Treated Water Formulated By Open-Air Hybrid Mode Discharge, Peng Lu, Daniela Boehm, Paula Bourke, Patrick J. Cullen

Articles

Plasma‐activated liquids (PAL) attract increasing interest with demonstrated biological effects. Plasma exposure in air produces stable aqueous reactive species which can serve as chemical diagnostics of PAL systems. Here, we tailor aqueous reactive species inside plasma‐activated water (PAW) through treating water with AC air spark and glow discharges in contact with water. Chemical probing demonstrated species specificity between two types of PAW. Spark discharge PAW contains urn:x-wiley:14381656:media:ppap201600207:ppap201600207-math-0006 and urn:x-wiley:14381656:media:ppap201600207:ppap201600207-math-0007, while urn:x-wiley:14381656:media:ppap201600207:ppap201600207-math-0008and urn:x-wiley:14381656:media:ppap201600207:ppap201600207-math-0009 are generated in glow discharge PAW. Species formation in different PAWs have been discussed in terms of discharge mechanisms and liquid phase chemistry process. Species specificity can provide …

Exploring Smoking, Mental Health And Smoking-Related Disease In A Nationally Representative Sample Of Older Adults In Ireland: A Retrospective Secondary Analysis, Annette Burns, Judith Strawbridge, Luke Clancy, Frank Doyle

Articles

Objective

Smoking is the leading preventable cause of death among individuals with mental health difficulties (MHD). The aim of the current study was to determine the impact of smoking on the physical health of older adults with MHD in Ireland and to explore the extent to which smoking mediated or moderated associations between MHD and smoking-related diseases.

Methods

Cross-sectional analysis of a nationally representative sample of 8175 community-dwelling adults aged 50 and over from The Irish Longitudinal Study on Ageing (TILDA) was undertaken. Multivariate adjusted logistic regression models were used to assess the association between MHD, smoking (current/past/never) and smoking-related …

Determination Of Sphingosine-1-Phosphate In Human Plasma Using Liquid Chromatography Coupled With Q-Tof Mass Spectrometry, Emmanuel Egom, Ross Fitzgerald, Rebecca Canning, Rebabonye B. Pharithi, Colin Murphy, Vincent Maher

Articles

Evidence suggests that high-density lipoprotein (HDL) components distinct from cholesterol, such as sphingosine-1-phosphate (S1P), may account for the anti-atherothrombotic effects attributed to this lipoprotein. The current method for the determination of plasma levels of S1P as well as levels associated with HDL particles is still cumbersome an assay method to be worldwide practical. Recently, a simplified protocol based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the sensitive and specific quantification of plasma levels of S1P with good accuracy has been reported. This work utilized a triple quadrupole (QqQ)-based LC-MS/MS system. Here we adapt that method for the determination of plasma …

Sarcopenia: Prevalence, And Impact On Operative And Oncologic Outcomes In The Multimodal Management Of Locally Advanced Esophageal Cancer, Jessie Elliott, Suzanne Doyle, Conor Murphy, Sinead King, Emer Guinan, Peter Beddy, Narayanasamy Ravi, John Reynolds

Articles

Objective: The aim of this article was to study the prevalence and significance of sarcopenia in the multimodal management of locally advanced esophageal cancer (LAEC), and to assess its independent impact on operative and oncologic outcomes.

Summary of background data: Sarcopenia in cancer may confer negative outcomes, but its prevalence and impact on modern multimodal regimens for LAEC have not been systematically studied.

Methods: Two hundred fifty-two consecutive patients were studied. Lean body mass (LBM), skeletal muscle index (SMI), and fat mass (FM) were determined pre-treatment, preoperatively, and 1 year postoperatively. Sarcopenia was defined by computed tomography (CT) at L3 …

The "Eyes" Have It?-Intra- And Inter-Observer Reproducibility Of The Pd-L1 Companion Diagnostic Assay, Steven G. Gray, Mark Wright, Stephen Finn

Articles

No abstract available.

Antibacterial Properties Of F-Doped Zno Visible Light Photocatalyst, Joanna Podporska-Carroll, Adam Myles, Brid Quilty, Declan Mccormack, Rachel Fagan, Steven Hinder, Dionysios D. Dionysiou, Suresh Pillai

Articles

Nanocrystalline ZnO photocatalysts were prepared by a sol–gel method and modified with fluorine to improve their photocatalytic anti-bacterial activity in visible light. Pathogenic bacteria such as Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) were employed to evaluate the antimicrobial properties of synthesized materials. The interaction with biological systems was assessed by analysis of the antibacterial properties of bacteria suspended in 2% (w/w) powder solutions. The F-doping was found to be effective against S. aureus (99.99% antibacterial activity) and E. coli (99.87% antibacterial activity) when irradiated with visible light. Production of reactive oxygen species is one of the major factors that …

An Ionic Liquid Based Sensor For Diclofenac Determination In Water, Emma Brennan, Pauline Futvoie, John Cassidy, Benjamin Schazmann

Articles

This paper details a miniaturised, solid state ion-selective electrode selective for diclofenac. The sensor comprises a novel ionic liquid electroactive material – an imidazolium–diclofenac ion associate. The ion associate is present in a plasticised poly(vinyl chloride) (PVC) membrane on planar carbon electrodes, with an intermediate poly(3,4-ethylenedioxythiophene) layer. The sensitivity and selectivity of the sensor were determined using chronopotentiometric methods. In response to diclofenac, a slope of −53.3 ± 3.6 mV/dec was observed. A limit of detection of 2.90 × 10−3 g L−1 is reported, with a linear range of 3.18 × 10−3 g L−1 to 3.18 g L−1. …

A Review Of The Recommendations Governing Quality Assurance Of Ultrasound Systems Used For Guidance In Prostate Brachytherapy, Andrea Jane Doyle, Deirdre King, Jacinta Browne

Articles

Ultrasound guided brachytherapy for the treatment of prostate cancer has become a routine treatment option, due to many benefits including patient recovery and dose localisation [1]; however it is not clear whether the standards which govern the image quality for these systems are adequate. Upon review of the recommended standards for ultrasound systems used in prostate brachytherapy procedures, the recommended tests do not appear to be specific to the clinical application of ultrasound guided prostate brachytherapy. Rather they are generic and similar to those recommended for other clinical applications such as general abdominal scanning [2]. Furthermore, there is growing evidence …

Broadband Acoustic Measurement Of The Agar-Based Tissue Mimicking Material: A Longitudinal Study, A. Rabell-Montiel, Jacinta Browne, S. D. Pye, T. A. Anderson, C. Moran

Articles

Commercially available ultrasound quality assurance test phantoms rely on the long-term acoustic stability of the tissue-mimicking-material (TMM). Measurement of the acoustic properties of the TMM can be technically challenging, and it is important to ensure its stability. The standard technique is to film-wrap samples of TMM and to measure the acoustic properties in a water bath. In this study, a modified technique was proposed whereby the samples of TMM are measured in a preserving fluid that is intended to maintain their characteristics. The acoustic properties were evaluated using a broadband pulse-echo substitution technique over the frequency range 4.5–50 MHz at …

Raman Spectroscopy For Cytopathology Of Exfoliated Cervical Cells, Fiona Lyng, Ir Ramos, Aidan Meade, O. Ibrahim, M. Mcmenamin, M. Mckenna, A. Malkin

Articles

No abstract provided.

Evaluation Of The Effect Of Plasma Treatment Frequency On The Activation Of Polymer Particles, Hisham Abourayana, Vladimir Milosavljevic, Peter Dobbyn, Denis Dowling

Articles

This study investigates the influence of treatment frequency (1–150 kHz) on the atmospheric plasma activation of both silicone and polyethylene terephthalate (PET) particles. These polymer particles with diameters in the range 3–5 mm, were treated using either helium or helium/oxygen gas mixtures, in a barrel atmospheric plasma system. The level of polymer particles activation was monitored using water contact angle measurements. The effect of plasma treatment frequency on barrel heating was monitored using an infrared thermographic camera, the maximum barrel temperature after 15 min treatment was found to be 98 °C at a frequency of 130 kHz. Optical emission spectroscopy …

The Nature Of Sequential Innovation, Christopher Buccafusco, Stefan Bechtold, Christopher Jon Sprigman

Articles

When creators and innovators take up a new task, they face a world of existing creative works, inventions, and ideas, some of which are governed by intellectual property (IP) rights. This presents a choice: Should the creator pay to license those rights? Or, alternatively, should the creator undertake to innovate around them? Our Article formulates this “build on/build around decision” as the fundamental feature of sequential creativity, and it maps a number of factors—some legal, some contextual—that affect how creators are likely to decide between building on existing IP or building around it. Importantly, creators are influenced by more than …

Functionality Screens, Christopher Buccafusco, Mark A. Lemley

Articles

Among intellectual property (IP) doctrines, only utility patents should protect function. Utility patents offer strong rights that place constraints on competition, but they only arise when inventors can demonstrate substantial novelty after a costly examination. Copyrights, trademarks, and design patents are much easier to obtain than utility patents, and they often last much longer. Accordingly, to prevent claimants from obtaining “backdoor patents,” the other IP doctrines must screen out functionality. As yet, however, courts and scholars have paid little systematic attention to the ways in which these functionality screens operate across and within IP law.We have four tasks in this …

How Strange The Change From Major To Minor, Peter Goodrich

Articles

No abstract provided.

An Equal Rights Amendment For The Twenty-First Century: Bringing Global Constitutionalism Home, Julie C. Suk

Articles

The last few years have seen a renewed push to constitutionalize sex equality in the United States. A generation after the federal Equal Rights Amendment (ERA) failed to be ratified by the requisite number of states, the ERA is on the platform of the 2017 Women's March on Washington. Oregon added a sex equality guarantee to its state constitution in 2014, joining 22 state constitutions and most constitutions around the world. Feminist coalitions, Hollywood celebrities, and members of Congress are vocally endorsing an ERA revival. Why is an ERA desired now, when judges have interpreted the Fourteenth Amendment to prohibit …

Fingerprints And Miscarriages Of Justice: "Other" Types Of Error And A Post-Conviction Right To Database Searching, Simon A. Cole, Barry Scheck

Articles

The article examines the role of fingerprint evidence in wrongful convictions and exonerations, focusing on errors beyond erroneous individualizations, such as missed exclusions and inconclusive results. It introduces a framework for categorizing fingerprint errors and advocates for increased access to post-conviction Automated Fingerprint Identification System (AFIS) searches to reduce miscarriages of justice. The authors argue that while DNA database searching is widely recognized as a tool for exonerations, fingerprint database searching remains underutilized despite its potential to uncover innocence. They propose expanding legal access to fingerprint evidence to align with the principles of truth, justice, and science.

Forecasting Peak-Day Consumption For Year-Ahead Management Of Natural Gas Networks, Ronan Oliver, Aidan Duffy, Bernard Enright, Rodger O'Connor

Articles

Security of supply is at the forefront of energy policy in the EU and elsewhere. This paper develops a methodology to forecast peak-day gas consumption for the consideration of gas transmission system operators. It is developed for the domestic and small-to-medium enterprise (SME) gas market, based on a review of current practice. From this assessment, a climate-adjusted network degree day (NDDCA) variable is developed to estimate the weather-dependent gas consumption of such markets. We show that solar radiation significantly affects gas consumption and should be considered in consumption models. The study also quantifies the difference in capacity required under alternative …

Optimising The Performance Of Cement-Based Batteries, Aimee Byrne, Shane Barry, Niall Holmes Dr., Brian Norton

Articles

The development of a battery using different cement-based electrolytes to provide a low but potentially sustainable source of electricity is described. The current, voltage, and lifespan of batteries produced using different electrolyte additives, copper plate cathodes, and (usually) aluminium plate anodes were compared to identify the optimum design, components, and proportions to increase power output and longevity. Parameters examined include water/cement ratio, anode to cathode surface area ratio, electrode material, electrode spacing, and the effect of sand, aggregate, salts, carbon black, silica fume, and sodium silicate on the electrolyte. The results indicate that the greatest and longest lasting power can …

Thermal Inactivation Analysis Of Water-Related Pathogens In Domestic Hot Water Systems, Liam Mccarton, Sean O'Hogain

Articles

This study aims to investigate whether hot water systems supplied with harvested rainwater present an increased risk to health over hot water systems supplied with potable mains water. It reviews previous studies investigating the health effects of utilising rainwater within domestic systems. The main risk to public health of mains-supplied hot water systems is the operation, maintenance, age, location and temperature of the system. Rainwater-harvesting systems contain an inherent water treatment train consisting of flocculation, settlement, sorption and bioreaction, and stored rainwater quality improves as metal and chemical contaminants settle to form sludge. Laboratory experiments were conducted using a variety …

Review: Epidemiological Evidence Of Groundwater Contribution To Global Enteric Disease, 1948–2015, Heather Murphy, Morgan Prioleau, Mark Borchardt, Paul Hynds

Articles

Globally, approximately 2.2 billion people rely on groundwater for daily consumption. It is widely accepted that groundwater is more pristine than surface water but while this assumption is frequently the case, groundwater is not ubiquitously free of contaminants; accordingly, this presumption can result in an unfounded and potentially hazardous sense of security among owners, operators and users. The current paper presents a review of published literature providing epidemiological evidence of the contribution of groundwater to global human enteric infection. An emphasis is placed on enteric pathogens transmitted via the faecal-oral route, and specifically those associated with acute gastrointestinal illness (AGI). …

Evaluation Of Levels Of Antibiotic Resistance In Groundwater-Derived E. Coli Isolates In The Midwest Of Ireland And Elucidation Of Potential Predictors Of Resistance, Jean O'Dwyer, Paul Hynds, Matthieu Pot, Catherine Adley, Michael Ryan

Articles

Antibiotic-resistant (pathogenic and non-pathogenic) organisms and genes are now acknowledged as significant emerging aquatic contaminants with potentially adverse human and ecological health impacts, and thus require monitoring. This study is the first to investigate levels of resistance among Irish groundwater (private wells) samples; Escherichia coli isolates were examined against a panel of commonly prescribed human and veterinary therapeutic antibiotics, followed by determination of the causative factors of resistance. Overall, 42 confirmed E. coli isolates were recovered from a groundwater-sampling cohort. Resistance to the human panel of antibiotics was moderate; nine (21.4%) E. coli isolates demonstrated resistance to one or more …

Geospatial Drivers Of The Groundwater Δ18o Isoscape In A Temperate Maritime Climate (Republic Of Ireland), S. Regan, R. Goodhue, O. Naughton, Paul Hynds

Articles

In recent years, the concept of “isoscapes” has been used to describe spatiotemporal stable isotope distributions within natural environments including groundwater systems at multiple scales. This study presents an updated groundwater δ18O isoscape for the Republic of Ireland and describes the climatic and geological drivers influencing 18O composition. In all, 142 geographically and geologically representative groundwater installations were sampled and analysed, in addition to 35 samples from six nested boreholes. Geospatially, Irish groundwater exhibits high δ18O values in southern and western coastal regions, becoming progressively depleted inland before reaching lowest measured values along the eastern coast, equating to a national …

An Overview Of Dissolved Organic Carbon In Groundwater And Implications For Drinking Water Safety, S. Regan, Paul Hynds, R. Flynn

Articles

Dissolved organic carbon (DOC) is composed of a diverse array of compounds, predominantly humic substances, and is a near ubiquitous component of natural groundwater, notwithstanding climatic extremes such as arid and hyper-arid settings. Despite being a frequently measured parameter of groundwater quality, the complexity of DOC composition and reaction behaviour means that links between concentration and human health risk are difficult to quantify and few examples are reported in the literature. Measured concentrations from natural/unpolluted groundwater are typically below 4 mg C/l, whilst concentrations above these levels generally indicate anthropogenic influences and/or contamination issues and can potentially compromise water safety. …

Stochastic Modelling For Levy Distributed Systems, Jonathan Blackledge, T Raja Rani

Articles

The purpose of this paper is to examine a range of results that can be derived from Einstein’s evolution equation focusing on (but not in an exclusive sense) the effect of introducing a L´evy distribution. In this context, we examine the derivation (as derived from the Einstein’s evolution equation) of the classical and fractional diffusion equations, the classical and generalised Kolmogorov-Feller equations, the evolution of self-affine stochastic fields through the fractional diffusion equation and the fractional Schr¨odinger equation, the fractional Poisson equation (for the time independent case), and, a derivation of the Lyapunov exponent. In this way, we provide a …

Information Hiding With Data Diffusion Using Convolutional Encoding For Super-Encryption, Jonathan Blackledge, Paul Tobin, J. Myeza, C.M. Adolfo

Articles

The unification of data encryption with information hiding methods continues to receive significant attention because of the importance of protecting encrypted information by making it covert. This is because one of the principal limitations in any cryptographic system is that encrypted data flags the potential importance of the data (i.e. the plaintext information that has been encrypted) possibly leading to the launch of an attack which may or may not be successful. Information hiding overcomes this limitation by making the data (which may be the plaintext or the encrypted plaintext) imperceptible, the security of the hidden information being compromised if …

Aphonic: Adaptive Thresholding For Noise Cancellation In Smart Mobile Environments, Ruairí De Fréin

Articles

We propose a signal-channel, adaptive threshold selection technique for binary mask construction, namely APHONIC, (AdaPtive tHreshOlding for NoIse Cancellation) for smart mobile environments. Using this mask, we introduce two noise cancellation techniques that perform robustly in the presence of real-world interfering signals that are typically encountered by mobile users: a violin busker, a subway and busy city square sounds. We demonstrate that when the power of the time-frequency components of the voice of a mobile user does not significantly overlap with the components of the interference signal, the threshold learning and noise cancellation techniques significantly improve the Signal-to-Interference Ratio (SIR) …

Magnetic Field Sensing Using Whispering Gallery Modes In A Cylindrical Microresonator Infilitrated With Ferronematic Liquid Crystal, Aseel Mahmood, Vishnu Kavungal, Sudad S. Ahmed, Peter Kopcansky, Vlasta Zavisova, Gerald Farrell, Yuliya Semenova

Articles

An all-fiber magnetic field sensor based on whispering-gallery modes (WGM) in a fiber micro-resonator infiltrated with ferronematic liquid crystal is proposed and experimentally demonstrated. The cylindrical microresonator is formed by a 1 cm-long section of a photonic crystal fiber infiltrated with ferronematic materials. Both ferronematics suspensions are prepared based on the nematic liquid crystal 1-(trans-4-Hexylcyclohexyl)-4-isothiocyanatobenzene (6CHBT) doped with rod-like magnetic particles in the first case and with spherical magnetic particles in the second case. WGMs are excited in the fiber microresonator by evanescent light coupling using a tapered fiber with a micron-size diameter. The Q-factor of the microresonator determined from …

Enhanced Network Voltage Management (Nvm) Techniques Under The Proliferation Of Rooftop Solar Pv Installation In Low Voltage Distribution Network (Lvdn), Shivananda Pukhrem, Malabika Basu, Michael Conlon, Keith Sunderland

Articles

Proliferation of rooftop solar PV distributed generator (PVDG) installation in low voltage distribution network (LVDN) imposes voltage fluctuation challenges that are a threat to distribution system operators. Reactive power control (RPC) methods are insufficient in isolation to combat the overvoltage fluctuations manifested in LVDN with significant grid-tied PVDG installations. Whereas active power curtailment (APC) control can alleviate the voltage fluctuation in such situations and it is achieved at the cost of reduced active power injection. This paper explores how deficiencies in both RPC and APC as separate approaches can be mitigated by suitably combining RPC and APC algorithms. Strategies combining …