Digital Commons Network^™

Synthesis, Characterisation And Dna Intercalation Studies Of Regioisomers Of Ruthenium (Ii) Polypyridyl Complexes, Laura Perdisatt, Samar Moqadasi, Luke O'Neill, Gary Hessman, Alessandra Ghion, Muhammad Qasim Mushtaq Warraich, Alan Casey, Christine O'Connor

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Regioisomers of the functional group of the main ligand (L) on a series of [Ru(phen)2L]2+and [Ru(bpy)2L]2+ complexes, where phen is 1,10 phenanthroline and bpy is 2,2′-bipyridine, were synthesised to investigate the interaction with deoxyribonucleic acid (DNA) as potential therapeutics. UV–Vis binding titrations, thermal denaturation and circular dichroism were used to evaluate their interaction with DNA. The conclusions indicated the significance of the auxiliary ligand; especially 1,10-phenanthroline has on the binding constants (Kb). The systematic variation of auxiliary ligand(phen or bpy), and polypyridyl ligand (4-(1H-Imidazo[4,5-f][1,10]phenanthrolin-2-yl)benzonitrile (CPIP), 2-(4-formylphenyl)imidazo[4,5-f] [1,10] phenanthroline (FPIP), 2-(4-bromophenyl)imidazo[4,5-f][1,10]phenanthroline (BPIP) and 2-(4-nitrophenyl)imidazo[4,5-f] [1,10] phenanthroline (NPIP), split in terms of …

It’S Not All About Price: Factors Associated With Roll-Your-Own Tobacco Use Among Young People - A Qualitative Study, Elizabeth Breslin, Joan Hanafin, Luke Clancy

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Background: Smoking prevalence in Ireland is falling in all age groups, but the prevalence of roll-your-own (RYO) tobacco use is rising among young people. This qualitative study aims to explore and understand the factors associated with young people's use of RYO products. Methods: Semi-structured individual and focus group interviews were conducted with young people aged 16-22 years. Participants were recruited from a higher education institution and youth organisations working with early school leavers across Dublin. In total, there were 62 participants in the study, consisting of 22 individual interviews and eight focus group interviews with 40 participants. Categoric and thematic …

European Power Markets–A Journey Towards Efficiency, Lucia Morales, Jim Hanly

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The liberalization process of European electricity markets has been a work in progress since early reforms beginning in the 1990's. A key goal of these reforms was to enable increased integration and attendant efficiency within these markets. In this paper, we analyse three major European electricity markets - (APXUK, NordPool and Phelix) – before and after the 2009/72/EC Directive was introduced, to examine the extent to which those markets are efficient and whether they have become more integrated. We find little evidence of significant long run relationships between the different markets. We also find that the NordPool and Phelix markets …

A Fresh Start To Bankruptcy Exemptions, Gary E. Sullivan

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Bankruptcy has broadly failed to deliver "fresh starts" to debtors Too often debtors return to states of financial distress following bankruptcy Although bankruptcy delivers a clean slate through the discharge of debts the efficacy of a fresh start depends on a second factor property exemptions While discharge frees a debtor from her existing debts property exemptions determine what property the debtor retains upon exiting bankruptcy For many debtors insufficient and suboptimal property exemption laws undermine fresh starts In fact under current bankruptcy law each state can reject federal bankruptcy exemptions by opting out Bankrupt debtors in "optout" states are forced …

Why Exempting Negligent Doctors May Reduce Suicide: An Empirical Analysis, J. Shahar Dillbary, Griffin Edwards, Fredrick E. Vars

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This article is the first to empirically analyze the impact of tort liability on suicide Counterintuitively our analysis shows that suicide rates increase when potential tort liability is expanded to include psychiatrists "” the very defendants who would seem best able to prevent suicide Using a 50state panel regression for 1981 to 2013 we find that states that would hold psychiatrists but not other doctors liable for malpractice resulting in a suicide experienced a 128 increase in suicides The effect is even stronger 168 when we include controls We do not believe this is because suicide prevention doesn't work Rather …

The Origins (And Fragility) Of Judicial Independence, Tara Leigh Grove

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The federal judiciary today takes certain things for granted Political actors will not attempt to remove Article III judges outside the impeachment process they will not obstruct federal court orders and they will not tinker with the Supreme Court's size in order to pack it with likeminded Justices And yet a closer look reveals that these "selfevident truths" of judicial independence are neither selfevident nor necessary implications of our constitutional text structure and history This Article demonstrates that many government officials once viewed these courtcurbing measures as not only constitutionally permissible but also desirable and politically viable methods of "checking" …

Access To Justice, Rationality And Personal Jurisdiction, Adam N. Steinman

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No abstract provided.

The Failure Of Sorry: An Empirical Evaluation Of Apology Laws, Health Care, And Medical Malpractice, Benjamin J. Mcmichael

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No abstract provided.

Violent Videos: Criminal Defense In A Digital Age, Amy F. Kimpel

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No abstract provided.

Developing Deaf Students Fraction Skills Requires Understanding Magnitude And Whole Number Division, Keith Mousley, Ronald R. Kelly

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Research has shown that fraction magnitude and whole number division are important precursors to learning and understanding fractions. Deaf and hard-of-hearing (DHH) students are consistently challenged with learning fractions from K-12 through college. Sixty DHH college students were tested for both their understanding of magnitude between two fractions and their ability to calculate whole number division. The results showed that both understanding the magnitude between two fractions and whole number division are significantly associated with accurately calculating arithmetic functions of fractions with like denominators and different denominators that required them to add, subtract, multiply, and divide two fractions. Understanding fraction …

Measurements Of Radiation Pressure Owing To The Grating Momentum, Ying-Ju Lucy Chu, Eric M. Jansson, Grover A. Swartzlander

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The radiation pressure force on a nearly single-order diffraction grating was measured for a transmission grating near the Littrow angles at wavelengths of 808 and 447 nm. The component of force parallel to the grating agreed well with our prediction, being proportional to the product of the grating order and the ratio of the wavelength and grating period. The normal component of force varied with the incident angle, vanishing near the Littrow angle as expected. The measurements verify a correspondence between the Fourier grating momentum and the mechanical momentum. This Letter provides opportunities for in-space fly-by-light sailcraft as well as …

Female Students View The Knowledge Of Foreign Languages As More Important For Careers In Tourism Than Male Students?, Nikolina Božinović, Joško Sindik

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The proficiency in multiple foreign languages is a basic assumption for successful communication in tourism. Tourism and mobility have a significant and important role, where intercultural contacts contribute to the development of intercultural dialogue. This paper attempts to explore gender differences in the perceptions of students from the Rochester Institute of Technology, RIT Croatia regarding the importance of knowing various foreign languages in tourism. The results obtained could help in raising the awareness of the importance of the role of learning and teaching foreign languages, with potential effects in developing and promoting tourism in Croatia. The key research finding is …

Identifying A Novel Role For Fractalkine (Cx3cl1) In Memory Cd8(+) T Cell Accumulation In The Omentum Of Obesity-Associated Cancer Patients, Melissa J. Conroy, Stephen G. Maher, Ashanty M. Ashanty, Suzanne Doyle, Emma K. Foley, John V. Reynolds, Aideen Long, Joanne Lysaght

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The omentum is enriched with pro-inflammatory effector memory CD8+ T cells in patients with the obesity-associated malignancy, esophagogastric adenocarcinoma (EAC) and we have identified the chemokine macrophage inflammatory protein-1alpha as a key player in their active migration to this inflamed tissue. More recently, others have established that subsets of memory CD8+ T cells can be classified based on their surface expression of CX3CR1; the specific receptor for the inflammatory chemokine fractalkine. CD8+ T cells expressing intermediate levels (CX3CR1INT) are defined as peripheral memory, those expressing the highest levels (CX3CR1HI) are effector memory/terminally differentiated and those lacking CX3CR1 (CX3CR1NEG) are classified …

Current And Future Technologies For Microbiological Decontamination Of Cereal Grains, Agatha Los, Dana Ziuzina, Paula Bourke

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Cereal grains are the most important staple foods for mankind worldwide. The constantly increasing annual production and yield is matched by demand for cereals, which is expected to increase drastically along with the global population growth. A critical food safety and quality issue is to minimize the microbiological contamination of grains as it affects cereals both quantitatively and qualitatively. Microorganisms present in cereals can affect the safety, quality, and functional properties of grains. Some molds have the potential to produce harmful mycotoxins and pose a serious health risk for consumers. Therefore, it is essential to reduce cereal grain contamination to …

Patient Experiences Of A Physiotherapy-Led Multidisciplinary Rehabilitative Intervention After Successful Treatment For Oesophago-Gastric Cancer, Annemarie Bennett, L. O'Neill, D. Connolly, E. M. Guinan, L. Boland, Suzanne Doyle, J. O'Sullivan, J. V. Reynolds, J. Hussey

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Purpose To qualitatively explore the perceived impact of a 12-week rehabilitative intervention for oesophago-gastric cancer survivors on their physical, mental and social wellbeing. Methods Of the 21 participants who completed the intervention, 19 took part in a semi-structured focus group interview. Four audio-taped focus groups were held, ranging in size from two to eight participants. Focus groups were transcribed and analysed using a descriptive qualitative approach. Results At recruitment, participants were 23.5 ± 15.2 months post-surgery and all had suboptimal fitness levels. Participants reported improvements in their physical capacity and ability to carry out activities of daily living during the …

Assessment Of The Disinfection Capacity And Eco-Toxicological Impact Of Atmospheric Cold Plasma For Treatment Of Food Industry Effluents, Apurva Patange, Daniela Boehm, Michelle Giltrap, Peng Lu, Patrick J. Cullen, Paula Bourke

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Generation of wastewater is one of the main environmental sustainability issues across food sector industries. The constituents of food process effluents are often complex and require high energy and processing for regulatory compliance. Wastewater streams are the subject of microbiological and chemical criteria, and can have a significant eco-toxicological impact on the aquatic life. Thus, innovative treatment approaches are required to mitigate environmental impact in an energy efficient manner. Here, dielectric barrier discharge atmospheric cold plasma (ACP) was evaluated for control of key microbial indicators encountered in food industry effluent. This study also investigated the eco-toxicological impact of cold plasma …

The Role Of Choice In Weight Loss Strategies: A Systematic Review And Meta-Analysis, Jill. M. Leavy, P. M. Clifton, Jennifer B. Keogh

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Effective strategies to achieve weight loss and long-term weight loss maintenance have proved to be elusive. This systematic review and meta-analysis aims to explore whether the choice of weight loss strategy is associated with greater weight loss. An electronic search was conducted using the MEDLINE (Medical Literature Analysis and Retrieval System Online, or MEDLARS Online), EMBASE (Excerpta Medica database), CINAHL (Cumulative Index to Nursing and Allied Health Literature), and PsycINFO (Database of Abstracts of Literature in the Field of Psychology, produced by the American Psychological Association and distributed on the association’s APA PsycNET) databases for clinical trials and randomized controlled …

Quantifying Excess Deaths Related To Heatwaves Under Climate Change Scenarios: A Multicountry Time Series Modelling Study, Yuming Guo, Antonio Gasparrini, Shanshan Li, Francesco Sera, Ana Maria Vicedo-Cabrera, Micheline De Sousa Zanotti Stagliorio Coêlho, Paulo Hilário Nascimento Nascimento Saldiva, Éric Lavigne, Benjawan Tawatsupa, Kornwipa Punnasiri, Ala Overcenco, Patricia Matus Correa, Nicolas Valdes Ortega, Haidong Kan, Samuel Osorio, Jouni J.K. Jaakkola, Niilo R.I. Ryti, Patrick J. Goodman, Ariana Zeka, Paola Michelozzi, Matteo Scortichini, Masahiro Hashizume, Honda, Yasushi Honda, Yasushi, Xerxes T. Seposo, Ho Young Kim, Aurelio Tobías, Carmen Iñiguez Fernández, Bertil Forsberg, Daniel Oudin Åström, Guo, Yue Leon Guo, Yue Leon, Bing Yu Chen, Antonella Zanobetti, Joel D. Schwartz, Tranngoc Ngoc Dang, Dung Do Van, Michelle L. Bell, Ben G. Armstrong, Ebi, Kristie L. Ebi, Kristie L., Shilu Tong

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Background: Heatwaves are a critical public health problem. There will be an increase in the frequency and severity of heatwaves under changing climate. However, evidence about the impacts of climate change on heatwave-related mortality at a global scale is limited. Methods and findings: We collected historical daily time series of mean temperature and mortality for all causes or nonexternal causes, in periods ranging from January 1, 1984, to December 31, 2015, in 412 communities within 20 countries/regions. We estimated heatwave–mortality associations through a two-stage time series design. Current and future daily mean temperature series were projected under four scenarios of …

Temperature-Related Mortality Impacts Under And Beyond Paris Agreement Climate Change Scenarios, Ana Maria Vicedo-Cabrera, Yuming Guo, Francesco Sera, Veronika Huber, Carl Friedrich Schleussner, Dann Mitchell, Shilu Tong, Micheline De Sousa Zanotti Stagliorio Coelho, Paulo Hilário Nascimento Nascimento Saldiva, Éric Lavigne, Patricia Matus Correa, Nicolas Valdes Ortega, Haidong Kan, Samuel Osorio, Jan Kyselý, Aleš Urban, Jouni J.K. Jaakkola, Niilo R.I. Ryti, Mathilde Pascal, Patrick J. Goodman, Ariana Zeka, Paola Michelozzi, Matteo Scortichini, Masahiro Hashizume, Yasushi Honda, Magali Hurtado-Díaz, Julio Gonzalez Cruz, Xerxes T. Seposo, Ho Kim, Aurelio Tobías, Carmen Iñiguez Fernández, Bertil Forsberg, Daniel Oudin Åström, Martina S. Ragettli, Martin Röösli, Yueleon Guo, Chang-Fu Wu, Antonella Zanobetti, Joel D. Schwartz, Michelle L. Bell, Tranngoc Ngoc Dang, Dung Do Van, C. Heaviside, Sotiris Vardoulakis, Shakoor Hajat, Andrew Haines, London School Of Hygiene & Tropical Medicine, London, United Kingdom London School Of Hygiene & Tropical Medicine, London, United Kingdom, Ben G. Armstrong, Kristie L. Ebi, Antonio Gasparrini

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The Paris Agreement binds all nations to undertake ambitious efforts to combat climate change, with the commitment to Bhold warming well below 2 °C in global mean temperature (GMT), relative to pre-industrial levels, and to pursue efforts to limit warming to 1.5 °C^. The 1.5 °C limit constitutes an ambitious goal for which greater evidence on its benefits for health would help guide policy and potentially increase the motivation for action. Here we contribute to this gap with an assessment on the potential health benefits, in terms of reductions in temperature-related mortality, derived from the compliance to the agreed temperature …

Carcinogenesis In Prostate Cancer: The Role Of Long Non-Coding Rnas, John Aird, Anne-Marie Baird, Marvin C.J Lim, Ray Mcdermott, Stephen P. Finn, Steven G. Gray

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LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion of growth suppressors, induction of angiogenesis and resistance to apoptosis. LncRNAs have been reported to play a role in prostate cancer, particularly in regulating the androgen receptor signalling pathway. In this review article, we summarise the role of 34 lncRNAs in prostate cancer with a particular focus on their role in the androgen receptor signalling pathway and the epithelial to mesenchymal transition pathway.

Comparison At The First Prenatal Visit Of The Maternal Dietary Intakes Of Smokers With Non-Smokers In A Large Maternity Hospital: A Cross-Sectional Study, Emer G. O'Malley, Shona Cawley, Ciara M.E. Reynolds, Rachel A.K. Kennedy, Anne Molloy, Michael Turner

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Using detailed dietary and supplement questionnaires in early pregnancy, we compared the dietary intakes of micronutrients and macronutrients at the first prenatal visit of women who reported continuing to smoke during pregnancy with the intakes of women who were non-smokers.

Maternal Anaemia And Folate Intake In Early Pregnancy, E.G. O'Malley, Shona Cawley, R.A.K. Kennedy, C.M.E. Reynolds, A. Molloy, M.J. Turner

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The World Health Organization recommends that women take 400 µg of folate supplementation daily throughout pregnancy. We examined the relationship between total folate intake from the diet and supplements at the first prenatal visit and haematological indices at this visit and subsequently.

Raman Spectroscopic Analysis Of High Molecular Weight Proteins In Solution - Considerations For Sample Analysis And Data Pre-Processing, Drishya Rajan Parachalil, Brenda B. Brankin, Jennifer Mcintyre, Hugh Byrne

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This study explores the potential of Raman spectroscopy, coupled with multivariate regression techniques and a protein separation technique (ion exchange chromatography), to quantitatively monitor diagnostically relevant changes in high molecular weight proteins in liquid plasma. Measurement protocols to detect the imbalances in plasma proteins as an indicator of various diseases using Raman spectroscopy are optimised, such that strategic clinical applications for early stage disease diagnostics can be evaluated. In a simulated plasma protein mixture, concentrations of two proteins of identified diagnostic potential (albumin and fibrinogen) were systematically varied within physiologically relevant ranges. Scattering from the poorly soluble fibrinogen fraction is …

Awareness And Prevalence Of Human Milk Sharing And Selling In The United States, Elizabeth O'Sullivan, Sheelagh R. Geraghty, Kathleen Maher Rasmussen

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There are limited data available about the prevalence of human milk (HM) sharing and selling in the general population. We aimed to describe attitudes toward HM selling among participants in a qualitative‐interview study and prevalence of HM sharing and selling among a national sample of U.S. mothers. Mothers (n = 41) in our qualitative‐interview study felt that sharing or donating HM was more common than selling; none had ever purchased or sold HM. Three themes related to HM selling emerged from this work: questioning the motives of those selling HM, HM selling limits access to HM to those with money, …

Infant Feeding Practices In China And Ireland - Ireland Chinese Mother, Qianling Zhou, Katherine Younger, John Kearney

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Introduction: Migration to another country may induce changes in infant feeding practices especially where such practices differ considerably between the two countries. This study was undertaken to compare the infant feeding practices between Chinese mothers who gave birth in Ireland (CMI) with immigrant Chinese mothers who gave birth in China (CMC), and to examine the factors that influence these practices. Methods: A cross-sectional self-administrated survey was conducted among a convenience sample of 322 Chinese mothers living in Ireland. Data were obtained from mailed questionnaires. Infant feeding practices between CMC and CMI were compared by Chi-square or independent sample t-test. Binary …

The Potential Of Cold Plasma For Safe And Sustainable Food Production, Paula Bourke, Dana Ziuzina, Daniela Boehm, Patrick J. Cullen, Kevin Keener

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In-package decontamination of foods using cold plasma has advanced this technology as a unit process for fresh foods decontamination and shelf-life extension.

Chemical residues of agricultural pesticides of varying structure can be degraded to safe or less-toxic structures using cold plasma.

Cold-plasma-mediated control of contaminants, along with the promotion of seed germination and plant growth, offers alternatives to current pesticides and fertilizers for agriculture.

Controlling plasma reactive species formulations in dry and liquid delivery formats advances the potential for understanding and successful translation to multiple points along the agriculture and food sectors.

Employing predictive microbiology, process optimization tools and a …

Haemagglutinin-Neuraminidase From Hpiv3 Mediates Human Nk Regulation Of T Cell Proliferation Via Nkp44 And Nkp46, Samantha Mcquaid, Sinead Loughran, Patrick Power, Paula Maguire, Dermot Walls, Maria Grazia Cusi, Claes Orvell, Patricia Johnson

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HPIV3 is a respiratory virus causing airway diseases, including pneumonia, croup, and bronchiolitis, during infancy and childhood. Currently there is no effective vaccine or anti-viral therapy for this virus. Studies have suggested that poor T cell proliferation following HPIV3 infection is responsible for impaired immunological memory associated with this virus. We have previously demonstrated that NK cells mediate regulation of T cell proliferation during HPIV3 infection. Here we add to these studies by demonstrating that the regulation of T cell proliferation during HPIV3 infection is mediated via NK receptors NKp44 and NKp46 and involves the surface glycoprotein haemagglutinin-neuraminidase but not …

Exploring The Association Of Urban Or Rural County Status And Environmental, Nutrition- And Lifestyle-Related Resources With The Efficacy Of Snap-Ed (Supplemental Nutrition Assistance Program-Education) To Improve Food Security, Rebecca L. Rivera, Jennifer Dunne, Melissa K. Maulding, Qi Wang, Dennis A. Savaiano, Sharon M. Nickols-Richardson, Heather A. Eicher-Miller

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Public Health Nutrition

Anti-Biofilm Activity Of Antibody Directed Against Surface Antigen Complement Receptor 3-Related Protein-Comparison Of Candida Albicans And Candida Dubliniensis, Jaroslava Chupáčová, Elisa Borghi, Giulia Morace, Agata Los, Helena Bujdáková

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Candida species (spp.) are a part of the normal human microbiota. Candida dubliniensis mostly colonizes the oral cavity and/or respiratory tract (Mahelová and Růžička 2017), especially in HIV-infected individuals (Coleman et al.1997; Sullivan et al.2004; Wahab et al.2014), while Candida albicans is a common inhabitant of the gastrointestinal tract, urogenital tract and oral cavity (Sardi et al.2013; Höfs, Mogavero and Hube 2016). Candidiasis is the most common global fungal infection (Sardi et al.2013). Candida albicans has been isolated in more than 50% of candidiasis; however, the number of non-albicans spp. able to cause serious candidiasis has increased in recent years …

Blunted Serum 25(Oh)D Response To Vitamin D3 Supplementation In Children With Autism, Conor Kerley, Basil Elnazir, Peter Greally, David Coghlan

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Introduction: Data suggest a potential role for vitamin D in autism spectrum disorder (ASD) prevention and treatment. It is likely that the serum response to vitamin D supplementation contributes to its effectiveness. Multiple factors affect serum vitamin D 25(OH)D response to supplementation.

Methods: We conducted post-hoc analysis of two double-blind, randomized, placebo-controlled trials (RCT) of vitamin D3 supplementation, one RCT involving children with ASD and another involving children with asthma. Both trials were conducted in the same geographic location (Dublin, Ireland, 53°N), conducted over Winter season and utilized the same vitamin D3 dose (2000 IU/day).

Results: We …