Digital Commons Network^™

Upscaling Of Apple By-Product By Utilising Apple Seed Protein As A Novel Wall Material For Encapsulation Of Chlorogenic Acid As Model Bioactive Compound, Asir Gani, Zanoor Ul Ashraf, Asima Shah, Azza Silotry Naik, Idrees Ahmed Wani, Adil Gani

Articles

Encapsulation is a versatile technique used to protect sensitive bioactive compounds under gastrointestinal conditions. In this study, nanoencapsulation of chlorogenic acid into the apple seed protein matrix was performed using the green technique ultrasonication to protect it from harsh gastric conditions and increase its biological activity and bioavailability upon digestion. Both nano (Nano-Chl) and native capsules (NT-Chl) were characterised by particle size, charge, structure, and morphology. The encapsulation efficiency, release behaviour, antioxidant and antidiabetic properties were also evaluated. The experimental results show that the particle size of the NT-Chl and Nano- Chl was found in the range of 1.4m to …

Modulation Of Gut Microbiota By Bioactive Compounds For Prevention And Management Of Type 2 Diabetes, Basista Rabina Sharma, Swarna Jaiswal, P.V. Ravindra

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Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic activities, and play a vital role in the production of functional metabolites from dietary substances. Dysbiosis of GM has been linked to the onset of T2DM and can be altered to attain eubiosis by intervention with various nutritional bioactive compounds such as polyphenols, prebiotics, and probiotics. This review presents an overview of the evidence and underlying mechanisms by which bioactive …

Impact Of Dry, Particle-Size Fractionation On Protein And Amino Acid Content Of Three Seaweed Species, Laura Healy, Xianglu Zhu, Milica Pojic, Mahesa Poojary, James Curtin, Uma Tiwari, Carl Sullivan, Brijesh K. Tiwari

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Market demand for “clean and green” food products is increasing, and so there is growing opportunity for the seaweed aquaculture industry to take a position as a key food producer in this area. In this study, in order to investigate the impact of dry fractionation on seaweed protein qualities, dried and milled seaweed powder from three seaweed species was sieved into 6 fractions (F1 to F6) of different particle size from >710 μm toμm. True protein, total protein and amino acid profiles were analyzed to evaluate the protein content and quality of three brown seaweed species commercially harvested in Ireland; …

Use Of Hydrothermal Carbonization And Cold Atmospheric Plasma For Surface Modification Of Brewer’S Spent Grain And Activated Carbon, Krystian Krochmalny, Halina Pawlak-Kruczek, Norbert Skoczylas, Mateusz Kudasik, Aleksandra Gajda, Renata Gnatowska, Monika Serafin-Tkaczuk, Tomasz Czapka, Amit Jaiswal, A. Vishwajeet, Amit Arora, Tomasz Hardy, Mateusz Jackowski, Michał Ostrycharczyk, Łukasz Nied´Zwiecki

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This paper presents results that show the effect of hydrothermal carbonization and subsequent cold plasma jet treatment with helium and argon on the structure and sorption properties of a material—spent brewery grain. Treatment of activated carbon, with a cold atmospheric plasma jet, was used comparatively. The effect of activation on the pore structure of the materials was carried out by the volumetric method at low pressure (N2, 77 K). The specific surface area as well as the total pore volume, average pore size, and pore size distribution were determined using different theoretical models. A high improvement in the sorption capacity …

Cook Like A Boss Online: An Adapted Intervention During The Covid-19 Pandemic That Effectively Improved Children’S Perceived Cooking Competence, Movement Competence And Wellbeing, Lynsey Hollywood, Johann Issartel, David Gaul, Amanda Mccloat, Elaine Mooney, Clare Elizabeth Collins, Fiona Lavelle

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The COVID-19 pandemic has further exacerbated physical inactivity, poor dietary intake and reduced mental wellbeing, contributing factors to non-communicable diseases in children. Cooking interventions are proposed as having a positive influence on children’s diet quality. Motor skills have been highlighted as essential for performance of cooking skills, and this movement may contribute to wellbeing. Additionally, perceived competence is a motivator for behaviour performance and thus important for understanding intervention effectiveness. Therefore, this research aimed to assess the effectiveness of an adapted virtual theory-based cooking intervention on perceived cooking competence, perceived movement competence and wellbeing.

Application Of Climate-Smart Forestry – Forest Manager Response To The Relevance Of European Definition And Indicators, Euan Bowditch, Giovanni Santopuoli, Boyżdar Neroj, Jan Svetlik Jan Svetlik, Mark Tominlson, Vivien Pohl, Admir Avdagić, Miren Del Rio, Tzetvan Zlatanov Tzetvan Zlatanov, Höhn Maria, Gabriela Jamnická, Yusuf Serengil, Murat Sarginci, Sigríður Júlía Brynleifsdóttir, Jerzy Lesinki, João C. Azevedo

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Climate change impacts are an increasing threat to forests and current approaches to management. In 2020, Climate-smart Forestry (CSF) definition and set of indicators was published. This study further developed this work by testing the definition and indicators through a forest manager survey across fifteen member European countries. The survey covered topic areas of demographics, climate change impacts, definition and indicators assessment, as well as knowledge and communication. Overall, forest managers considered the threat of climate change to their forests as high or critical and 62% found the CSF definition clear and concise; however, the minority suggested greater simplification or …

Cell Death Induced In Glioblastoma Cells By Plasma-Activated-Liquids (Pal) Is Primarily Mediated By Membrane Lipid Peroxidation And Not Ros Influx, Sebnem Gunes, Zhonglei He, Evanthia Tsoukou, Sing Wei Ng, Daniela Boehm, Beatriz Pinheiro, Paula Bourke, Renee Malone, Patrick J. Cullen, Wenxin Wang, James Curtin

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Since first identified in 1879, plasma, the fourth state of matter, has been developed and utilised in many fields. Nonthermal atmospheric plasma, also known as cold plasma, can be applied to liquids, where plasma reactive species such as reactive Oxygen and Nitrogen species and their effects can be retained and mediated through plasma-activated liquids (PAL). In the medical field, PAL is considered promising for wound treatment, sterilisation and cancer therapy due to its rich and relatively long-lived reactive species components. This study sought to identify any potential antagonistic effect between antioxidative intracellularly accumulated platinum nanoparticles (PtNPs) and PAL. We found …

Data Driven Bayesian Network To Predict Critical Alarm, Joseph Mietkiewicz, Anders Madsen

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Modern industrial plants rely on alarm systems to ensure their safe and effective functioning. Alarms give the operator knowledge about the current state of the industrial plants. Trip alarms indicating a trip event indicate the shutdown of systems. Trip events in power plants can be costly and critical for the running of the operation.This paper demonstrates how trips events based on an alarm log from an offshore gas production can be reliably predicted using a Bayesian network. If a trip event is reliably predicted and the main cause of it is identified, it will allow the operator to prevent it. …

Improvement Of The Fine Tuning Algorithm, Joseph Mietkiewicz, Anders Madsen

Articles

Khalil El Hindi has developed a fine-tuning algorithm to
improve the classification accuracy of the Naive Bayes. His algorithm optimizes the conditional probability tables of the Naive Bayes after the
training phase. The values of the probabilities of a variable are modified if it causes misclassification of a training instance. The algorithm out-performs in many cases the Naive Bayes. We analyze the performance
of the algorithm, discussed its issues, and compare it to a modified algorithm. The new algorithm simplifies the formula used in the fine-tuning algorithm and uses a more efficient scoring metric, the Brier score, to
fine-tune the …

Development Of Modular And Adaptive Laboratory Set-Up For Neuroergonomic And Human-Robot Interaction Research, Marija Savkovic, Carlo Caiazzo, Marko Djapan, Arso M. Vukic´ Evi, Milos Pusica, Ivan Macˇ Užic

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The industry increasingly insists on academic cooperation to solve the identified problems such as workers' performance, wellbeing, job satisfaction, and injuries. It causes an unsafe and unpleasant working environment that directly impacts the quality of the product, workers' productivity, and effectiveness. This study aimed to give a specialized solution for tests and explore possible solutions to the given problem in neuroergonomics and human-robot interaction. The designed modular and adaptive laboratory model of the industrial assembly workstation represents the laboratory infrastructure for conducting advanced research in the field of ergonomics, neuroergonomics, and human-robot interaction. It meets the operator's anatomical, anthropometric, physiological, …

Intragovernmental Speech And Sanction, Katherine A. Shaw

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This Essay, prepared as part of a symposium on Professor Helen Norton’s The Government’s Speech and the Constitution, asks what role, if any, we should understand the Constitution to play in mediating disputes over speech between and among government entities. Focusing on the examples of impeachment and censure, the piece considers scenarios in which one arm of government takes action in response to the speech of another arm or entity of government, exploring what role the Constitution should play in shaping or constraining those responses.

Taking Misappropriation Seriously: State Common Law Disgorgement Actions For Insider Trading, Jeanne L. Schroeder

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In two recent cases, Kokesh v. SEC, and Liu v. SEC, the U.S. Supreme Court cut back substantially on one of the Securities and Exchange Commission’s most important enforcement powers. This is the ability to seek disgorgement from persons who violate the federal securities laws, depriving them of their ill-gotten gains.

Previously, the Supreme Court had developed a largely property-based theory of insider trading. Why is insider trading evil? Because material nonpublic information is property that the trader has fraudulently obtained and must not use for his own purposes

In this article I bring these thoughts together. I …

What War Did To The Academy, What The Academy Did To War: A 20-Year Retrospective On The Effects Of The Post-9/11 Wars, Deborah Pearlstein

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The history of the legal academy’s impact on the way states fight wars is hardly one of unmixed glory. It was a law professor moonlighting for President Lincoln who authored “Instructions for the Government of Armies of the United States in the Field” during the Civil War, a code still recognized worldwide today for having laid critical groundwork for the modern law of war. It was likewise a law professor whose work came to serve as both theoretical and practical justification for the sweeping powers of the Nazi state. So it should perhaps be unsurprising that, two decades of engagement …

Pandemic Rules: Covid-19 And The Prison Litigation Reform Act’S Exhaustion Requirement, Betsy Ginsberg, Margo Schlanger

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For over twenty-five years, the Prison Litigation Reform Act (PLRA) has undermined the constitutional rights of incarcerated people. For people behind bars and their allies, the PLRA makes civil rights cases harder to bring and harder to win—regardless of merit. We have seen the result in the wave of litigation relating to the COVID-19 pandemic. Beginning March 2020, incarcerated people facing a high risk of infection because of their incarceration, and a high risk of harm because of their medical status, began to bring lawsuits seeking changes to the policies and practices augmenting the danger to them. Time and again, …

Supported Decision-Making: Potential And Challenges For Older Persons, Morgan K. Whitlatch, Rebekah Diller

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In recent years, supported decision-making (SDM) has gained traction as a recognized alternative to guardianship for persons with disabilities in the United States. To date, SDM has not been as widely recognized as an alternative for older people, particularly those struggling with cognitive decline. This paper explores some of the obstacles that have prevented SDM from being used more broadly by older people, identifies ways of surmounting some of those obstacles, and makes recommendations for ways that SDM can be used in the aging context.

Credit Scoring Duality, Pamela Foohey, Sara Sternberg Greene

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Credit scoring is central to people’s financial growth and prosperity or financial decline and stagnation. People with a good credit score and accompanying credit report can buy opportunities to advance economically. The benefits they reap from their attractiveness to lenders and employers helps feed their future success. In contrast, people with a fair or poor credit score become stuck in cycle of high interest rates and costly loan terms, large required down payments, and denied applications for rentals, cell phone plans, and employment. Employers, service providers, lenders, and alternative financial service providers have begun to use alternative credit scoring models, …

Remote Justice & Domestic Violence: Process Pluralism Lessons From The Pandemic, Andrea K. Schneider, Heather Hlavka, Sameena Mulla, Erin Schubert, Aleksandra J. Snowden

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Domestic violence procedures, like so many court processes around the world, were forced to go online and remote during the pandemic. The impact was dramatic—there were fewer restraining order petitions filed in the first place and an even lower amount granted. In short, domestic violence survivors, among the most vulnerable in our court system, were even more challenged in the last two years. Like many court systems, Milwaukee will never go back to being fully in-person for all procedures in conjunction with domestic violence. The evolving hybrid choices could provide additional access to justice, or these processes could create additional …

Dynamic Pricing Algorithms, Consumer Harm, And Regulatory Response, Alexander Mackay, Samuel Weinstein

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Pricing algorithms are rapidly transforming markets, from ride-sharing, to air travel, to online retail. Regulators and scholars have watched this development with a wary eye. Their focus so far has been on the potential for pricing algorithms to facilitate explicit and tacit collusion. This Article argues that the policy challenges pricing algorithms pose are far broader than collusive conduct. It demonstrates that algorithmic pricing can lead to higher prices for consumers in competitive markets and even in the absence of collusion. This consumer harm can be initiated by a single firm employing a superior pricing algorithm. Higher prices arise from …

Tax Harmony: The Promise And Pitfalls Of The Global Minimum Tax, Reuven Avi-Yonah, Young Ran (Christine) Kim

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The rise of globalization has become a double-edged sword for countries seeking to implement a beneficial tax policy. On one hand, there are increased opportunities for attracting foreign capital and the benefits that increased jobs and tax revenue brings to a society. However, there is also much more tax competition among countries to attract foreign capital and investment. As tax competition has grown, effective corporate tax rates have continued to be cut, creating a “race-to-the-bottom” issue.

In 2021, 137 countries forming the OECD/G20 Inclusive Framework on BEPS passed a major milestone in reforming international tax by successfully introducing the framework …

Steering Loan Modifications Post-Pandemic, Pamela Foohey, Dalie Jimenez, Christopher K. Odinet

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As part of federal and state relief programs created during the COVID-19 pandemic, many American households received pauses on their largest debts, particularly on mortgages and student loans. Others may have come to agreements with their lenders, likewise pausing or altering payment on other debts, such as auto loans and credit cards. This relief allowed households to allocate their savings and income to necessary expenses, like groceries, utilities, and medicine. But forbearance does not equal forgiveness. At the end of the various relief periods and moratoria, people will have to resume paying all their debts, the amounts of which may …

Law's Duct Tape? Using Public Nuisance To Fix The Holes In Administrative Law, Anthony J. Sebok

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No abstract provided.

What’S Going On? An Overview Of Diversity, Equity, And Inclusion Dispute Resolution Initiatives In New York, Robyn Weinstein, Michelle Lavrichenko

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Leaders in the dispute resolution profession in New York State have been working to implement various fellowships, mentorship programs, scholarships, and other initiatives aimed at increasing diversity, equity, and inclusion in the field of dispute resolution. This article will provide an overview of the current ADR-related diversity, equity, and inclusion initiatives throughout New York and introduce you to five individuals participating in DEI ADR fellowships and mentorship programs across the state.

Fluctuating Temperature Modifies Heat-Mortality Association Around The Globe, Yao Wu, Bo Wen, Shanshan Li, Antonio Gasparrini, Shilu Tong, Ala Overcenco, Aleš Urban, Alexandra Schneider, Alireza Entezari, Ana Maria Vicedo-Cabrera, Antonella Zanobetti, Antonis Analitis, Ariana Zeka, Aurelio Tobias, Barrack Alahmad, Ben Armstrong, Bertil Forsberg, Carmen Íñiguez, Caroline Ameling, César De La Cruz Valencia, Chrisofer Åström, Danny Houthuijs, Do Van Dung, Dominic Royé, Ene Indermitte, Eric Lavigne, Fatemeh Mayvaneh, Fiorella Acquaotta, Francesca De’Donato, Francesco Sera, Gabriel Carrasco-Escobar, Haidong Kan, Hans Orru, Ho Kim, Iulian-Horia Holobaca, Jan Kyselý, Joana Madureira, Joel Schwartz, Klea Katsouyanni, Magali Hurtado-Diaz, Martina S. Ragettli, Masahiro Hashizume, Mathilde Pascal, Micheline De Sousa Zanotti Stagliorio Coélho, Noah Scovronick, Paola Michelozzi, Patrick J. Goodman, Paulo Hilario Nascimento Saldiva, Rosana Abrutzky, Samuel Osorio, Tran Ngoc Dang, Valentina Colistro, Veronika Huber, Whanhee Lee, Xerxes Seposo, Yasushi Honda, Michelle L. Bell, Yuming Guo

Articles

Studies have investigated the effects of heat and temperature variability (TV) on mortality. However, few assessed whether TV modifies the heat-mortality association. Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries. TV was calculated as the standard deviation of the average of the same and previous days’ minimum and maximum temperatures. We used location-specific quasi-Poisson regression models with an interaction term between the cross-basis term for mean temperature and quartiles of TV to obtain heat-mortality associations under each quartile of TV, and then pooled estimates at the country, regional, and global …

Investigation Of The Suitability Of A Commercial Radiation Sensor For Pretherapy Dosimetry Of Radioiodine Treatment Patients, Janet O'Callaghan, Dervil Cody, Jennie Cody

Articles

Radioiodine (I-131) therapy is routinely used to treat conditions of the thyroid. Dosimetry planning in advance of I-131 therapy has been shown to improve patient treatment outcomes. However, this pretherapy dosimetry step requires multiple outpatient appointments and is not feasible for patients living at greater distances. Here, the feasibility of a commercially available smartphone-operated radiation sensor (Smart Geiger Pro, Technonia) for at-home patient pretherapy dosimetry has been investigated. The influence of both treatment-specific parameters (radioisotope activity, gamma photon energy, patient size) and external factors (sensor placement and motion) on the ability of the radiation sensor to accurately quantify radiation dose …

Preprocessing Strategies For Sparse Infrared Spectroscopy: A Case Study On Cartilage Diagnostics, Valeria Tafintseva, Tiril Aurora Lintvedt, Johanne Heitmann Solheim, Boris Zimmermann, Hafeez Ur Rehman, Vesa Virtanen, Rubina Shaikh, Ervin Nippolainen, Isaac Afara, Simo Saarakkala, Lassi Rieppo, Patrick Krebs, Polina Fomina, Boris Mizaikoff, Achim Kohler

Articles

The aim of the study was to optimize preprocessing of sparse infrared spectral data. The sparse data were obtained by reducing broadband Fourier transform infrared attenuated total re-flectance spectra of bovine and human cartilage, as well as of simulated spectral data, comprising several thousand spectral variables into datasets comprising only seven spectral variables. Different preprocessing approaches were compared, including simple baseline correction and normalization procedures, and model-based preprocessing, such as multiplicative signal correction (MSC). The optimal preprocessing was selected based on the quality of classification models established by partial least squares discriminant analysis for discriminating healthy and damaged cartilage samples. …

Infrared Spectroscopy Is Suitable For Objective Assessment Of Articular Cartilage Health, V. Virtanen, V. Tafintseva, R. Shaikh, E. Nippolainen, J. Haas, I. O. Afara, J. Töyräs, H. Kröger, J. Solheim, B. Zimmermann, A. Kohler, B. Mizaikoff, M. Finnilä, L. Rieppo, S. Saarakkala

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Objective: To evaluate the feasibility of Fourier transform infrared attenuated total reflectance (FTIR-ATR) spectroscopy to detect cartilage degradation due to osteoarthritis and to validate the methodology with osteochondral human cartilage samples for future development towards clinical use. Design: Cylindrical (d ​= ​4 ​mm) osteochondral samples (n ​= ​349) were prepared from nine human cadavers and measured with FTIR-ATR spectroscopy. Afterwards, the samples were assessed with Osteoarthritis Research Society International (OARSI) osteoarthritis cartilage histopathology assessment system and divided into two groups: 1) healthy (OARSI 0–2) and 2) osteoarthritic (OARSI 2.5–6). The classification was done with partial least squares discriminant analysis model …

Classification Of Cytological Samples From Oral Potentially Malignant Lesions Through Raman Spectroscopy: A Pilot Study, Isha Behl, Genecy Calado, Anika Vishwakarma, Damien Traynor, Stephen Flint, Sheila Galvin, Claire M. Healy, Marina Leite Pimentel, Alison Malkin, Hugh J. Byrne, Fiona M. Lyng

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The potential of Raman microspectroscopy of exfoliated cells has been demonstrated for oral cancer diagnosis. In this study, brush biopsies were collected from the buccal mucosa/tongue of healthy donors (n = 31) and from oral mucosal dysplastic lesions (n = 31 patients). Raman spectra were acquired and subjected to partial least squares-discriminant analysis (PLS-DA). The patient samples could be differentiated from healthy donor samples with 96% sensitivity and 95% specificity. Furthermore, PLS-DA models were developed based on cytopathological and histopathological assessment. Low and high grade dysplasia could be discriminated with 64% sensitivity and 65% specificity based on cytopathological assessment, while …

Synthesis Of Fast Curing, Water-Resistant And Photopolymerizable Glass For Recording Of Holographic Structures By One- And Two-Photon Lithography, Tatsiana Mikulchyk, Mohamed Oubaha, Alicja Kaworek, Brendan Duffy, Markus Lunzer, Aleksandr Ovsianikov, Sabad-E Gul, Izabela Naydenova, Dervil Cody

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Advancements in hybrid sol-gel technology have provided a new class of holographic materials as photopolymerizable glasses. Recently, a number of photosensitive glass compositions with high dynamic range and high spatial resolution have been reported and their excellent capability for volume holography has been demonstrated. Nevertheless, challenges remain, particularly in relation to the processing time and environmental stability of these materials, that strongly affect the performance and durability of the fabricated holograms. State-of-the-art photopolymerizable glasses possess long curing times (few days) required to achieve thick films, thus limiting the industrial implementation of this technology and its commercial viability. This article presents …

Improving The Holographic Recording Characteristics Of A Water-Resistant Photosensitive Sol–Gel For Use In Volume Holographic Optical Elements, Brian Rogers, Tatsiana Mikulchyk, Mohamed Oubaha, Dervil Cody, Suzanne Martin, Izabela Naydenova

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Continual improvements to holographic recording materials make the development of volume holographic optical elements increasingly more attainable for applications where highly efficient, lightweight diffractive optical elements can replace conventional optics. A fast-curing, water resistant photosensitive sol–gel capable of volume holographic recording has recently drawn attention for its extreme environmental and physical robustness, in particular its water/moisture and scratch resistance. However, to date, the refractive index modulation has been limited. While water-resistant properties are invaluable in the face of the weathering which many practical systems for outdoor applications will endure, high refractive index modulation is also important in order to facilitate …

Characterisation Of Holographic Recording In Environmentally Stable Photopolymerisable Glass, Tatsiana Mikulchyk, Pamela Stoeva, Alicja Kaworek, Mohamed Oubaha, Brian Rogers, Suzanne Martin, Dervil Cody, Izabela Naydenova

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Photopolymerisable glasses are holographic recording materials which provide good recording capability, improved dimensional stability, and negligible shrinkage. Recently, a novel photopolymerisable hybrid sol-gel (PHSG) for holographic recording of volume gratings has been reported. The PHSG has significantly improved gelation time and high water resistance, both of which make it an attractive material for mass production of holographic optical elements (HOEs) with no sensitivity to ambient humidity. In order to achieve full control over the performance of the material and further improve its properties, a study of grating formation under holographic patterning is essential. This paper reports characterisation of the grating …