Digital Commons Network^™

Michelot Yogogombaye V. Republic Of Senegal, Charles C. Jalloh

Articles

No abstract provided.

Strategies For The Elimination Of Matrix Effects In The Lc-Ms/Ms Analysis Of The Lipophilic Toxins Okadaic Acid And Azaspiracid-1 In Molluscan Shellfish, Jane Kilcoyne, Elie Fux

Articles

Considerable efforts are being made worldwide to replace in vivo assays with instrumental methods of analysis for the monitoring of marine biotoxins in shellfish. Analysis of these compounds by the preferred technique of LC-MS/MS is challenged by matrix effects associated with shellfish tissue components. In methods validation, assessment of matrix interferences is imperative to ensure the accuracy of analytical results. We evaluated matrix interferences in the analysis of okadaic acid (OA) and azaspiracid 1 (AZA1) in mollucscan shellfish by using a conventional acidic method on electrospray triple stage quadrapole (TSQ) and hybrid quadrupole time of flight (QToF) instruments, with matrix …

Least-Cost Control Of Agricultural Nutrient Contributions To The Gulf Of Mexico Hypoxic Zone, Sergey Rabotyagov, Todd Campbell, Manoj Jha, Philip W Gassman, Jeffrey Arnold, Lyubov Kurkalova, Silvia Secchi, Hongli Feng, Catherine L Kling

Articles

In 2008, the hypoxic zone in the Gulf of Mexico, measuring 20 720 km2, was one of the two largest reported since measurement of the zone began in 1985. The extent of the hypoxic zone is related to nitrogen and phosphorous loadings originating on agricultural fields in the upper Midwest. This study combines the tools of evolutionary computation with a water quality model and cost data to develop a trade-off frontier for the Upper Mississippi River Basin specifying the least cost of achieving nutrient reductions and the location of the agricultural conservation practices needed. The frontier allows policymakers and stakeholders …

Hunting In The Shadows For Savings: Reevaluating Standing Orders, Roger L. Cross

Articles

Standing orders are remnants of an early period of library acquisition, and while they can provide a useful service in limited cases most have outlived that usefulness and should be cancelled. In a period of restricted funding and increased digital reliance the need for standing orders has diminished; indeed often the standing orders received are no longer relevant to an institution's mission. However, identifying standing orders is complicated by the nature of their classification as a serial rather than a book or monograph. This paper aims to describe the various types of standing orders and how to identify them.

State Fiscal Policies And Transitory Income Fluctuations, James R. Hines Jr.

Articles

State and local expenditure and tax revenue respond less to the business cycle than do federal spending and revenue, thereby reducing the countercyclicality of total government expenditure and revenue. This paper considers forces responsible for the cyclical pattern of state expenditure and revenue. Annual fluctuations in state personal income are associated with small changes in state spending and significant changes in tax receipts; receipt of federal grants is associated with greater state spending. Tax collections, and to a lesser degree expenditure, of larger states are more closely associated with annual income fluctuations than are the tax collections and expenditure of …

Traveling Concepts: Substantive Equality On The Road, Susanne Baer

Articles

Ideas travel. Even legal concepts migrate on the globe. However, it is a contested issue whether migration is a good idea. We may enjoy traveling ourselves, but many people in the world of law are somewhat worried if we take legal baggage along. Some claim that legal baggage never arrives at its destination and challenge the very possibility of what some call a legal transplant. Others claim that we already live in transnational legal contexts, while still others claim that migration occurs, and that modifies each legal concept on the road in rather significant ways, which may render the project …

The Deepwater Horizon Oil Spill: Potential Insurance Coverage Implications, Lynn K. Neuner, W. Nicholson Price

Articles

More than 300 lawsuits have already been filed in Louisiana, Florida, Texas, Mississippi, and Alabama against BP and other corporations involved in the Deepwater Horizon oil spill, including Transocean, Halliburton, and Cameron, with thousands more anticipated. This article briefly addresses the contours of the coverage lawsuit already filed against BP and other coverage disputes we may see in the future.

3dq: Threat Dome Visibility Querying On Mobile Devices, James Carswell, Keith Gardiner, Junjun Yin

Articles

3DQ (Three Dimensional Query) is our mobile spatial interaction (MSI) prototype for location and orientation aware mobile devices (i.e. today's sensor enabled smartphones). The prototype tailors a military style threat dome query calculation using MSI with hidden query removal functionality for reducing “information overload” on these off-the-shelf devices. The effect gives a more accurate and expected query result for Location-Based Services (LBS) applications by returning information on only those objects visible within a user’s 3D field-of-view. Our standardised XML based request/response design enables any mobile device, regardless of operating system and/or programming language, to access the 3DQ web-service interfaces.

The Redemption Puzzle, Reuven S. Avi-Yonah

Articles

After the adoption of partial integration in 2003, there has been only a modest rise in dividends, but a sixfold increase in redemptions. This article argues that the explanation for that lies in the different treatment of dividends and capital gains to foreign shareholders and that Congress should respond by making sections 302 and 304 inapplicable to foreign shareholders.

Mechanistic Studies Of In Vitro Cytotoxicity Of Poly(Amidoamine) Dendrimers In Mammalian Cells, Sourav Prasanna Mukherjee, Fiona Lyng, Amaya Garcia, Maria Davoren, Hugh Byrne

Articles

Poly(amidoamine) (PAMAM) dendrimer nanoparticles have been demonstrated to elicit a well defined cytotoxicological response from mammalian cell lines, the response increasing systematically with dendrimer generation and number of surface amino groups. In this work, using generation G4, G5, and G6 dendrimers, this systematic response is furthermore demonstrated for the generation of reactive oxygen species, lysosomal activity, and the onset of apoptosis and levels of DNA damage. The results are consistent with a pathway of localisation of PAMAM dendrimers in the mitochondria leading to ROS production causing oxidative stress, apoptosis and DNA damage. ROS production is co-located in the mitochondria, and …

Influence Of Hybrid Organic–Inorganic Sol–Gel Matrices On The Photophysics Of Amino-Functionalized Uv-Sensitizers, Mohamed Oubaha, R. Copperwhite, Catherine Boothman, A. Ovsianikov, R. Kiyan, V. Purlys, M. O'Sullivan, Colette Mcdonagh, B. Chichkov, R. Gadonas, B.D. Maccraith

Articles

Recent interest in photolithographic processes employing single and two-photon absorption processes have afforded advanced opportunities to fabricate both planar and three-dimensional microstructures. The fabrication of such structures is dependent on the local polymerization of the organic moieties using photoinitiating molecules, and a key parameter to consider is the dependency of the photoreactivity of these initiators on the matrices in which they are dispersed. To our knowledge, there has been no comprehensive investigation reported on the photoreactivity dependency of commercially available photoinitiators inserted within hybrid sol–gel materials. The aim of this paper is to highlight and explain the influence of the …

Inverse Scattering Transform For The Degasperis–Procesi Equation, Adrian Constantin, Rossen Ivanov, Jonatan Lenells

Articles

We develop the Inverse Scattering Transform (IST) method for the Degasperis- Procesi equation. The spectral problem is an sl(3) Zakharov-Shabat problem with constant boundary conditions and finite reduction group. The basic aspects of the IST such as the construction of fundamental analytic solutions, the formulation of a Riemann-Hilbert problem, and the implementation of the dressing method are presented.

A Monocular Marker-Free Gait Measurement System, Jane Courtney, Annraoi M. De Paor

Articles

This paper presents a new, user-friendly, portable motion capture and gait analysis system for capturing and analyzing human gait, designed as a telemedicine tool to monitor remotely the progress of patients through treatment. The system requires minimal user input and simple single-camera filming (which can be acquired from a basic webcam) making it very accessible to nontechnical, nonclinical personnel. This system can allow gait studies to acquire a much larger data set and allow trained gait analysts to focus their skills on the interpretation phase of gait analysis. The design uses a novel motion capture method derived from spatiotemporal segmentation …

Payback: The 1920/1921 Agib Sltu Strike In The Dublin Building Industry, John Hogan

Articles

In late 1920 a strike began in the building industry in Dublin that was to last until June of the following year. It effectively shut down building sites all across the city. The primary protagonists involved in the dispute were the Ancient Guild of Incorporated Brick and Stonelayers Trade Union (AGIBSLTU) and the building employers association, the Dublin Building Trades Employers’ Association (DBTEA). Both of these bodies had fought a bitterly contested lockout 15 years before, which had almost destroyed the union. In 1920, by dint of wider economic circumstances, and a belligerent determination, the union was to have the …

Barley For Brewing: Characteristic Changes During Malting, Brewing And Applications Of Its By-Products, Mahesh Gupta, Nissreen Abu-Ghannam, Eimear Gallaghar

Articles

Barley is the basic raw material for brewing. Its chemical composition, brewing, and technological indices are highly determinative for the beer quality and the economical efficiency of the brewing process. Barley is rich in protein, carbohydrates, dietary fibers, minerals, and vitamins. The presence of non starch polysaccharides as mixed linkage (1-3),(1-4)-β-D-glucans and arabinoxylans together with the enzymes are responsible for barley modification. Malting is a complex process that involves many enzymes; important ones are α-amylase, β-amylase, α-glucosidase, and limit dextrinase. During the process of malting and brewing, the by-products left after separation of the wort are rich in protein, fibers, …

Welfare As Happiness, Jonathan Masur, John Bronsteen, Christopher Buccafusco

Articles

No abstract provided.

Implementing The 2005 American Heart Association Guidelines, Including Use Of The Impedance Threshold Device, Improves Hospital Discharge Rate After In-Hospital Cardiac Arrest, K Thigpen, Scott Davis, Roberta Basol, Peggy Lange, Sandeep Jain, John Olsen, Bernard Erickson, Timothy Schuchard

Articles

OBJECTIVE:

To determine the impact of the 2005 American Heart Association cardiopulmonary resuscitation (CPR) guidelines, including use of an impedance threshold device (ITD), on survival after in-hospital cardiac arrest.

METHODS:

Two community hospitals that tracked outcomes after in-hospital cardiac arrest pooled and compared their hospital discharge rate before and after implementing the 2005 American Heart Association CPR guidelines (including ITD) in standardized protocols. In CPR we used the proper ventilation rate, allowed full chest-wall recoil, conducted continuous CPR following intubation, and used an ITD. We compared historical control data from a 12-month period at St Cloud Hospital, St Cloud, Minnesota, …

Study Of The Efficacy, Biodistribution, And Safety Profile Of Therapeutic Gutless Adenovirus Vectors As A Prelude To A Phase I Clinical Trial For Glioblastoma, Akm Ghulam Muhammad, Mariana Puntel, Marianela Candolfi, A Salem, Kader Yagiz, C Farrokhi, Kurt Kroeger, Weidong Xiong, James Curtin, Chunyan Liu, K Lawrence, Niyati Bondale, Jonathan Lerner, G Baker, David Foulad, Robert Pechnick, Donna Palmer, Philip Ng, Pedro Lowenstein, Maria Castro

Articles

Glioblastoma multiforme (GBM) is the most common and most aggressive primary brain tumor in humans. Systemic immunity against gene therapy vectors has been shown to hamper therapeutic efficacy; however, helper-dependent high-capacity adenovirus (HC-Ad) vectors elicit sustained transgene expression, even in the presence of systemic anti-adenoviral immunity. We engineered HC-Ads encoding the conditional cytotoxic herpes simplex type 1 thymidine kinase (TK) and the immunostimulatory cytokine fms-like tyrosine kinase ligand 3 (Flt3L). Flt3L expression is under the control of the regulatable Tet-ON system. In anticipation of a phase I clinical trial for GBM, we assessed the therapeutic efficacy, biodistribution, and clinical and …

Letter To The Editor, Charlotte Johnston Molloy, Clare Corish, John Kearney, Noirin Hayes, Corina Glennon Slattery

Articles

No abstract provided.

The Curious Matter Of Time And Space: A Conversation Between Michael Warren And Noel J. Brady, Noel Brady

Articles

Interview between Michael Warren (Artist/Sculptor) and Noel J Brady, with specific discussion on the issue of gravity and presence.

A Suggested Building Block Geometry Without Continuous Radial Joints Of Possible Relevance For Particle Detectors, Jim Mcgovern

Articles

A geometry for concentrc shells or tubes, built-up from a single rhombohedral block type, is described. Continuous radial joints are avoided.

Effect Of Hydrothermal Processing On Colour, Antioxidant And Free Radical Scavenging Capacities Of Edible Irish Brown Seaweeds, Gaurav Rajauria, Amit Jaiswal, Nissreen Abu-Ghannam, Shilpi Gupta

Articles

The effect of heat processing on change in colour (ΔE), level of bioactive compounds and overall antioxidant capacity in raw and heat processed Irish brown seaweeds was investigated. Raw seaweeds were heated at 85, 95, 100, 110 and 121 °C for 15 min in an autoclave and the samples were extracted with 60% methanol. Total phenol (TPC), total tannin (TTC), DPPH• scavenging and metal chelating ability (FIC) were significantly higher (p < 0.05) at 85 °C while the value of ΔE, total flavonoid (TFC), total sugar (TSC), lipid peroxidation and H2O2 scavenging capacity were higher at 95 °C, as compared to raw seaweeds, in all the species studied. Results showed that heat treatment affects not only the content of bioactive compounds in seaweeds but also beneficial biological activity associated with these compounds which can suggest new processing for the application of seaweeds extract as nutraceutical.

Handle With Care, Ellen Hazelkorn

Articles

This article discusses the impact of rankings on higher education.

What Can Post-Catholic Ireland Learn From France?, Eamon Maher

Articles

Material reproduced by kind permission of Doctrine and Life.

False Dichotomies, Facts And Values, And The Snares Of Objectivism: Planning For Leisure From An Experiential Perspective?, Ross Neville

Articles

Despite the fact that the experiential perspective has had a profound impact on the way we view leisure behaviour, experiential matters have been renounced for being overtly subjective. As a corollary, experiential matters have been castigated for their inability to offer concrete criteria for leisure policy and the provisions of services. This paper argues that this dismissal of experiential matters is based on an overinflated dichotomy – the fact/value dichotomy – and that, by valorising objectivist approaches to managing leisure resources, experiential matters have become nothing more than a policy-making faux pas. The paper argues that while experiential matters bring …

Poldowski Rediscovered, David Mooney

Articles

This is a brief magazine article, commissioned to celebrate the 75th anniversary of the death of Poldowski. It contains a biographical sketch and a description of compositions.

Rethinking Trust Law Reform: How Prudent Is Modern Prudent Investor Doctrine?, Stewart E. Sterk

Articles

During the 1990s, modern portfolio theory provided the theoretical foundation for significant reforms in trust investment doctrine-reforms that freed trustees from a legal regime in which they faced potential liability for making "speculative" investments. The reforms enabled trustees to pursue investment policies that protected beneficiaries against inflation risk. But the reforms worked too well; they encouraged trustees to invest a higher percentage of trust assets in equities just in time for a decade that has seen two precipitous stock market declines. Although no sensible investment strategy would have avoided losses during these periods of market turmoil, the doctrinal reforms endorsed …

The Hydra, Carl E. Schneider

Articles

Almost nobody favors long consent forms for prospective research subjects. Almost everybody thinks they interfere with informed consent's purpose-good decisions. Nevertheless, almost everybody believes consent forms have long been getting longer. Years ago, Paul Appelbaum lamented the "tendency to cram ever more information into consent forms." Weeks ago, Ilene Albala and her colleagues (one of them Appelbaum) reported in IRE: Ethics & Human Research that the length of one institutional review board's forms "increased roughly linearly by an average of 1.5 pages per decade. In the 1970s, the average consent form was less than one page long and often only …

Validated Real-Time Energy Models For Small-Scale Grid-Connected Pv-Systems, Lacour Ayompe, Aidan Duffy, Sarah Mccormack, Michael Conlon

Articles

This paper presents validated real-time energy models for small-scale grid-connected PV-systems suitable for domestic application. The models were used to predict real-time AC power output from a PV system in Dublin, Ireland using 30-min intervals of measured performance data between April 2009 and March 2010. Statistical analysis of the predicted results and measured data highlight possible sources of errors and the limitations and/or adequacy of existing models, to describe the temperature and efficiency of PV-cells and consequently, the accuracy of power prediction models. PV-system AC output power predictions using empirical models for PV-cell temperature and efficiency prediction showed lower percentage …

Looking Beyond Full Relationship Recognition For Couples Regardless Of Sex: Abolition, Alternatives, And/Or Functionalism, Edward D. Stein

Articles

In the context of recent accomplishments in the quest for full marriage equality for same-sex couples, this article considers three proposals for reform to the law of adult domestic relations: (i) the abolition of the legal institution of marriage; (ii) the development of a broad “menu” of alternative forms of relationship recognition in addition to marriage; and (iii) the embracing of a functionalist approach to relationship recognition whereby relationships that share significant functional attributes with marriages are, in certain ways, given the same legal treatment as marriages. The article contends that advocates and theoreticians should strive for more than just …