Digital Commons Network^™

Evolutionary Paths To Macrolide Resistance In A Neisseria Commensal Converge On Ribosomal Genes Through Short Sequence Duplications, Jordan C. Raisman, Michael A. Fiore, Lucille Tomin, Joseph K. O. Adjei, Virginia X. Aswad, Jonathan Chu, Christina J. Domondon, Ben A. Donahue, Claudia A. Masciotti, Connor G. Mcgrath, Jo Melita, Paul A. Podbielski, Madelyn R. Schreiner, Lauren J. Trumpore, Peter C. Wengert, Emalee A. Wrightstone, André O. Hudson, Crista B. Wadsworth

Articles

Neisseria commensals are an indisputable source of resistance for their pathogenic relatives. However, the evolutionary paths commensal species take to reduced susceptibility in this genus have been relatively underexplored. Here, we leverage in vitro selection as a powerful screen to identify the genetic adaptations that produce azithromycin resistance (� 2 μg/mL) in the Neisseria commensal, N. elongata. Across multiple lineages (n = 7/16), we find mutations that reduce susceptibility to azithromycin converge on the locus encoding the 50S ribosomal L34 protein (rpmH) and the intergenic region proximal to the 30S ribosomal S3 protein (rpsC) through short tandem duplication events. Interestingly, …

The Constitutional Guarantee Of Criminal Justice Transparency, Aliza Plener Cover

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This Article identifies and explores a transparency guarantee that permeates the Constitution's criminal procedure provisions. This guarantee protects multiple dimensions of transparency - which I categorize as participatory, informational, and corporal--through overlapping structural safeguards and individual rights, and through protections afforded to both the public and the accused. Despite the strength and pervasiveness of the overarching transparency guarantee, the discrete provisions from which it is derived are often peripheral in today's criminal justice system, which is dominated by plea bargaining and incarceration rather than trials and public-square punishment. And, because the constitutional transparency protections are viewed in clause-bound isolation, modern …

Vaccine Diplomacy Game: The Race For Soft Power, Isaac Antwiboasiako

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This article examines the motivations and dynamics of the donors and suppliers of the covid-19 vaccines to the global south countries in the context of public diplomacy to wield soft power. Thus, it investigates how the West and East use the vaccines as a public diplomacy tool to influence public opinion in other nations or continents in order to either enhance their global image and reputation or exert some form of international influence or have new allies. The article argues that covid-19 vaccines are a soft power asset; therefore, the manufacturing nations may use them to shape their target foreign …

The Stoic Litigator, Leonard M. Niehoff

Articles

A variety of events over the past several years have renewed my conversations with some reliable old friends. And I mean very old. I refer here to the Stoic philosophers, most of whom did their thinking and writing around the turn of the Common Era.

The Stoics took their name from the central square of Athens, the Stoa Poikile, where Zeno is generally credited with founding the school in the early part of the third century BCE. Various philosophers over the next five centuries identified themselves as Stoics, so the label takes in lots of personalities and lots of territory. …

Willard Hurst, Technological Changes, And The Transformation Of American Public Law, William J. Novak

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As Sociobiologist E.O. Wilson once famously framed the “problem of humanity”: “We have paleolithic emotions; medieval institutions; and god-like technology.” America’s greatest philosopher John Dewey similarly placed this yawning gap between rapidly expanding technological change and slowly evolving human emotions and institutions at the heart of what he called The Public and Its Problems. Indeed, Dewey traced the origins of the modern American state as well as what he termed “the Great Society” to the new and modern technologies in production and commerce and steam and electricity that “resulted in a social revolution.” Without warning, Dewey argued, traditional local communities …

Reallocating Redevelopment Risk, Michael C. Pollack

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Scores of cities across the country face devastating financial crises, and the COVID-19 pandemic has brought even more to the brink. But economically distressed municipalities have few places to turn for help. Saddled by rising unemployment, weak tax bases, and state law limitations on deficit spending and debt assumption, they generally cannot spend their way out. And as conditions deteriorate, mobile capital and labor move to greener pastures, further hollowing out the cities they leave behind. With state and federal lifelines tenuous at best, offers by large developers to redevelop an area of the city can thus appear to be …

1d Conditional Generative Adversarial Network For Spectrum-To-Spectrum Translation Of Simulated Chemical Reflectance Signatures, Cara Murphy, John Kerekes

Articles

The classification of trace chemical residues through active spectroscopic sensing is challenging due to the lack of physics-based models that can accurately predict spectra. To overcome this challenge, we leveraged the field of domain adaptation to translate data from the simulated to the measured domain for training a classifier. We developed the first 1D conditional generative adversarial network (GAN) to perform spectrum-to-spectrum translation of reflectance signatures. We applied the 1D conditional GAN to a library of simulated spectra and quantified the improvement in classification accuracy on real data using the translated spectra for training the classifier. Using the GAN-translated library, …

1d Conditional Generative Adversarial Network For Spectrum-To-Spectrum Translation Of Simulated Chemical Reflectance Signatures, Cara P. Murphy, John Kerekes

Articles

The classifcaton of trace chemical residues through actve spectroscopic sensing is challenging due to the lack of physics-based models that can accurately predict spectra. To overcome this challenge, we leveraged the feld of domain adaptaton to translate data from the simulated to the measured domain for training a classifer. We developed the frst 1D conditonal generatve adversarial network (GAN) to perform spectrum-to-spectrum translaton of refectance signatures. We applied the 1D conditonal GAN to a library of simulated spectra and quantfed the improvement in classifcaton accuracy on real data using the translated spectra for training the classifer. Using the GAN-translated library, …

Physics-Guided Neural Network For Predicting Chemical Signatures, Cara Murphy, John Kerekes

Articles

Achieving high classification accuracy on trace chemical residues in active spectroscopic sensing is challenging due to the limited amount of training data available to the classifier. Such classifiers often rely on physics-based models for generating training data though these models are not always accurate when compared to measured data. To overcome this challenge, we developed a physics-guided neural network (PGNN) for predicting chemical reflectance for a set of parameterized inputs that is more accurate than the state-of-the-art physics-based signature model for chemical residues. After training the PGNN, we use it to generate a library of predicted spectra for training a …

Decolonial Feminist Theory: Embracing The Gendered Colonial Difference In Management And Organisation Studies, Jennifer Manning

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Feminist theories in management and organization studies, each with their own ontological and epistemological assumptions, offer critical perspectives of the status quo to challenge our idea of progress in the discipline, yet there is limited engagement with ideas, theories, or practices from the lived experiences of Global South women. Decolonial feminism engages with debates pertaining to coloniality/ modernity and indigenous identity and gender in Latin America, while providing a space for the voices and lived experiences of marginalized, non‐Western(ised) women. Positioned in the context of Guatemalan Maya women and deploying critical insights from decolonial feminists, I unpack how the discourse …

Statebuilding In The Peace Agreements Of Sudan And South Sudan, Gene Carolan

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This article presents a retrospective analysis of the principal peace agreements to emanate from the North–South conflict in Sudan and the civil war in South Sudan. In doing so, it argues that statebuilding practices dating back to the inception of the Sudanese state continue to inform and undermine contemporary efforts to resolve the conflicts in both countries. The article makes a unique contribution by linking the legacy of peace agreements in Sudan and South Sudan to the crises of governance that plague both countries today. In doing so, it seeks to further the discussion on statebuilding as part of a …

Latin American Film, Mirna Vohnsen

Articles

The scholarship on Latin American film in 2019 speaks of the rich and diverse critical studies that are being conducted in the field. This year the studies encompass a wide range of topics, like the role of Netflix in the production, distribution and consumption of Latin American films; the contention between national cinemas and transnationalism; and the re-examination of films made in the last century. Although publications showcasing the cinemas of Argentina, Mexico and Cuba continue to dominate the field, two special issues have been published shedding light on lesser-studied cinemas, Studies in Spanish and Latin American Cinemas has dedicated …

Third Parties With Benefits, Casey E. Faucon

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No abstract provided.

Cr Cybermar As A Solution Path Towards Cybersecurity Soundness In Maritime Logistics Domain, Monica Canepa, Fabio Ballini, Dimitrios Dalaklis, Seyedvahid Vakili, Luis Miguel Colmenares Hernandez

Articles

Cybersecurity is now considered as one of the main challenges for the maritime sector. At the same time, the maritime transport industry remains one of the most relevant and driving sectors for the global economy in terms of both the number and operations of active companies, and infrastructure and investments, thanks to the policies pushed to attract the latter. Maritime information systems, whether on board ships or in ports, are numerous, built with standard components available on the market and in many cases designed without factoring in well the ever-growing cyber risk. Digital infrastructure has become essential in operating and …

The Right To Benefit From Big Data As A Public Resource, Mary D. Fan

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The information that we reveal from interactions online and with electronic devices has massive value—for both private profit and public benefit, such as improving health, safety, and even commute times. Who owns the lucrative big data that we generate through the everyday necessity of interacting with technology? Calls for legal regulation regarding how companies use our data have spurred laws and proposals framed by the predominant lens of individual privacy and the right to control and delete data about oneself. By focusing on individual control over droplets of personal data, the major consumer privacy regimes overlook the important question of …

The Pure Theory Of Law Is A Hole In The Ozone Layer, Peter Goodrich

Articles

The article critiques the Pure Theory of Law, arguing that it is inadequate and detached from the dynamic and creative aspects of legal practice. The author advocates for a reimagined legal theory that integrates critical perspectives, embodiment, and a connection to the natural world, emphasizing the need for adaptability and responsiveness over static dogma.

Practical Model For Improved Classification Of Trace Chemical Residues On Surfaces In Active Spectroscopic Measurements, Cara P. Murphy, John P. Kerekes, Derek A. Wood, Anish K. Goyal

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No abstract provided.

Practical Model For Improved Classification Of Trace Chemical Residues On Surfaces In Active Spectroscopic Measurements, Cara P. Murphy, John Kerekes, Derek Wood, Anish Goyal

Articles

Trace chemical detection and classification in stand-off reflection-based spectro- scopic data is challenging due to the variability of measured data and the lack of physics-based models that can accurately predict spectra. Most available models assume that the chemical takes the form of spherical particles or uniform thin films. A more realistic chemical presentation that could be encountered is that of a nonuniform chemical film that is deposited after evaporation of the solvent that contained the chemical. We present an improved signature model for this type of solid film. The proposed model, called sparse transfer matrix, includes a log-normal distribution of …

Designing Analog Learning Games: Genre Affordances, Limitations And Multi-Game Approaches, Owen Gottlieb, Ian Schreiber

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This chapter explores what the authors discovered about analog games and game design during the many iterative processes that have led to the Lost & Found series, and how they found certain constraints and affordances (that which an artifact assists, promotes or allows) provided by the boardgame genre. Some findings were counter-intuitive. What choices would allow for the modeling of complex systems, such as legal and economic systems? What choices would allow for gameplay within the time of a class-period? What mechanics could promote discussions of tradeoff decisions? If players are expending too much cognition on arithmetic strategizing, could that …

Sport Diplomacy And Uk Soft Power: The Case Of Mount Everest, Richard Woodward

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Sport is widely acknowledged as an important contributor to the United Kingdom’s soft power resources. This article aims to broaden and deepen our understanding of sport and soft power in the United Kingdom through a case study of British expeditions to, and the eventual conquest of, Mount Everest. Based on original archival research, the article demonstrates that British state institutions intervened systematically and strategically to expedite, and massage the story of, the ascent of Everest to burnish British prestige and present a favourable image to the world. In doing so, the article provides evidence that sport has been intrinsic to …

Innovation In A Legal Vacuum: The Uncertain Legal Landscape For Shared Micro-Mobility, David Pimentel

Articles

The last few years have seen an explosion in the number and size shared of micro-mobility systems (“SMMS”) across the United States. Some of these systems have seen extraordinary success and the potential benefit of these systems to communities is considerable. However, SMMS have repeatedly ran into legal barriers that either prevent their implementation entirely, confuse and dissuade potential users, or otherwise limit SMMS’s potential positive impact. This paper reflects a detailed study of state laws relating to SMMS and the platforms commonly used in these systems. The study uncovered many inconsistencies with micro-mobility laws across the country. Currently, many …

Zealous Administration: The Deportation Bureaucracy, Geoffrey Heeren

Articles

An agency's culture shapes its lawmaking. Under certain conditions, agency culture dominates decision-making so strongly that it mutes the influence of those factors that administrative law scholars have traditionally focused on including presidential will, judicial oversight, internal resistance, and public opinion. We call this undertheorized phenomenon "zealous administration." The immigration enforcement bureaucracy has vast discretion to remove unauthorized immigrants from the United States. Current immigration policies-such as indiscriminate deportation, family separation, and harsh detention-represent the most prominent example of zealous administration in the federal government. This Article focuses on that bureaucracy to plumb the causes and effects of zealous administration …

Constitutionalism In Unexpected Places, Farah Peterson

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No abstract provided.

Constitutional Rights In The Machine Learning State, Aziz Huq

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No abstract provided.

Civil Procedure And Economic Inequality, Maureen Carroll

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How well do procedural doctrines attend to present-day economic inequality? This Essay examines that question through the lens of three doctrinal areas: the “irreparable harm” prong of the preliminary injunction standard, the requirement that discovery must be proportional to the needs of the case, and the due process rights of class members in actions for injunctive relief. It concludes that in each of those areas, courts and commentators could do more to take economic inequality into account.

Article Ii Vests Executive Power, Not The Royal Prerogative, Julian Davis Mortenson

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Article II of the United States Constitution vests “the executive power” in the President. For more than two hundred years, advocates of presidential power have claimed that this phrase was originally understood to include a bundle of national security and foreign affairs authorities. Their efforts have been highly successful. Among constitutional originalists, this so-called “Vesting Clause Thesis” is now conventional wisdom. But it is also demonstrably wrong. Based on an exhaustive review of the eighteenth-century bookshelf, this Article shows that the ordinary meaning of “executive power” referred unambiguously to a single, discrete, and potent authority: the power to execute law. …

Whistleblowing In The Irish Military: The Cost Of Exposing Bullying And Sexual Harassment, John Hogan, Sharon Feeney, Grace Flynn

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Whistleblowing has gained increasing media attention over the past 40 years, as incidents of abuse and wrongdoing associated with businesses, religious institutions, the media and politics have come to light. In this article, we investigate the consequences of a military whistleblower’s actions for both himself and the military institution that he was a part of. The case concerns former army officer Dr. Tom Clonan and his findings concerning the bullying and sexual harassment of female personnel in the Irish Defence Forces at the turn of the century. As these revelations came to light over 17 years ago we are able …

International Law And Political Philosophy: Uncovering New Linkages, Steven R. Ratner

Articles

The legal regime regulating cross-border investment gives key rights to foreign investors and places significant duties on states hosting that investment. It also raises distinctive moral questions due to its potential to constrain a state’s ability to manage its economy and protect its people. Yet international investment law remains virtually untouched as a subject of philosophical inquiry. The questions of international political morality surrounding investment rules can be mapped through the lens of two critiques of the law – that it systemically takes advantage of the global South and that it constrains the policy choices of states hosting investment. Each …

Human Rights Conditions: What We Know And Why It Matters, David Weissbrodt, Patrick Finnegan

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No abstract provided.

Wicked Crypto, Alan Rozenshtein

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No abstract provided.