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The Iris Clinic: A Protocol For A Mixed-Methods Study Evaluating The Management Of Hyperemesis Gravidarum, Eileen O'Brien, Jean Doherty, Sarah Louise Killeen, Melanie Bennett, Lillian Murtagh, Sinead Curran, Suzanne Murphy, Helen Mchale, Lucille Sheehy Jan 2023

The Iris Clinic: A Protocol For A Mixed-Methods Study Evaluating The Management Of Hyperemesis Gravidarum, Eileen O'Brien, Jean Doherty, Sarah Louise Killeen, Melanie Bennett, Lillian Murtagh, Sinead Curran, Suzanne Murphy, Helen Mchale, Lucille Sheehy

Articles

Hyperemesis Gravidarum (HG) is a severe form of nausea and vomiting in pregnancy that affects 0.3–3% of women and has profound nutritional, physical and psychological consequences. Research is lacking regarding the most effective management of the condition. In response to patient feedback, a multidisciplinary HG day-case service (IRIS Clinic) was launched in 2020 at The National Maternity Hospital, Ireland. The clinic provides routine, day-case care in a comfortable space with pre-booked appointments. The MDT involves midwives, dietitians, perinatal mental health, obstetrics and pharmacy, and the nature of the clinic enables peer-to-peer support. As this clinic is the first of its …


Valorisation Of Crustacean And Bivalve Processing Side Streams For Industrial Fast Time-To-Market Products: A Review From The European Union Regulation Perspective, Yang Zou, Marc Heyndrickx, Jane Debode Jane Debode, Katleen Raes, Donatella De Pascale, Patrice Behan, Michelle Giltrap, Christine O'Connor, Runar Gjerp Solstad, Kjersi Lian, Themistoklis Altintzoglou, Ragnhild Dragoy, Nathalie Maria Scheers, Ingrid Undeland, Johan Robbens Jan 2023

Valorisation Of Crustacean And Bivalve Processing Side Streams For Industrial Fast Time-To-Market Products: A Review From The European Union Regulation Perspective, Yang Zou, Marc Heyndrickx, Jane Debode Jane Debode, Katleen Raes, Donatella De Pascale, Patrice Behan, Michelle Giltrap, Christine O'Connor, Runar Gjerp Solstad, Kjersi Lian, Themistoklis Altintzoglou, Ragnhild Dragoy, Nathalie Maria Scheers, Ingrid Undeland, Johan Robbens

Articles

A massive amount of crustaceans and bivalves are consumed each year, leading to millions of tons of processing side streams from the seafood industry. Considering the current trend of (bio)circular and zero-waste food production, crustacean and bivalve processing side streams (CBPS) seem a promising and emerging resource for producing high-value-added products. This paper highlights the general composition of CBPS with high commercial values, namely, protein, lipids, carotenoids, minerals and chitins. The extraction strategies of these fractions, including conventional chemical and environmentally friendly methods, are also discussed. This review presents and summarises CBPS as raw materials for developing fast time-to-market products …


Inclusion4eu: Co-Designing A Framework For Inclusive Software Design And Development, Dympna O'Sullivan, Emma Murphy, Andrea Curley, John Gilligan, Damian Gordon, Anna Becevel, Svetlana Hensman, Mariana Rocha, Claudia Fernandez, Michael Collins, J. Paul Gibson, Gordana Dodig-Crnkovic, Gearoid Kearney, Sarah Boland Jan 2023

Inclusion4eu: Co-Designing A Framework For Inclusive Software Design And Development, Dympna O'Sullivan, Emma Murphy, Andrea Curley, John Gilligan, Damian Gordon, Anna Becevel, Svetlana Hensman, Mariana Rocha, Claudia Fernandez, Michael Collins, J. Paul Gibson, Gordana Dodig-Crnkovic, Gearoid Kearney, Sarah Boland

Articles

Digital technology is now pervasive, however, not all groups have uniformly benefitted from technological changes and some groups have been left behind or digitally excluded. Comprehensive data from the 2017 Current Population Survey shows that older people and persons with disabilities still lag behind in computer and internet access. Furthermore unique ethical, privacy and safety implications exist for the use of technology for older persons and people with disabilities and careful reflection is required to incorporate these aspects, which are not always part of a traditional software lifecycle. In this paper we present the Inclusion4EU project that aims to co-design …


Survey Of Routing Techniques-Based Optimization Of Energy Consumption In Sd-Dcn, Mohammed Nsaif, Gergely Kovásznai, Ali Malik, Ruairí De Fréin Jan 2023

Survey Of Routing Techniques-Based Optimization Of Energy Consumption In Sd-Dcn, Mohammed Nsaif, Gergely Kovásznai, Ali Malik, Ruairí De Fréin

Articles

The increasing power consumption of Data Center Networks (DCN) is becoming a major concern for network operators. The object of this paper is to provide a survey of state-of-the-art methods for reducing energy consumption via (1) enhanced scheduling and (2) enhanced aggregation of traffic flows using Software-Defined Networks (SDN), focusing on the advantages and disadvantages of these approaches. We tackle a gap in the literature for a review of SDN-based energy saving techniques and discuss the limitations of multi-controller solutions in terms of constraints on their performance. The main finding of this survey paper is that the two classes of …


Hierarchy, Race & Gender In Legal Scholarly Networks, Nicholson W. Price, Keerthana Nunna, Jonathan Tietz Jan 2023

Hierarchy, Race & Gender In Legal Scholarly Networks, Nicholson W. Price, Keerthana Nunna, Jonathan Tietz

Articles

A potent myth of legal academic scholarship is that it is mostly meritocratic and mostly solitary. Reality is more complicated. In this Article, we plumb the networks of knowledge co-production in legal academia by analyzing the star footnotes that appear at the beginning of most law review articles. Acknowledgments paint a rich picture of both the currency of scholarly credit and the relationships among scholars. Building on others’ prior work characterizing the potent impact of hierarchy, race, and gender in legal academia more generally, we examine the patterns of scholarly networks and probe the effects of those factors. The landscape …


The Early Years Of Congress’S Anti-Removal Power, Aaron Nielson, Christopher J. Walker Jan 2023

The Early Years Of Congress’S Anti-Removal Power, Aaron Nielson, Christopher J. Walker

Articles

Judges and scholars have long debated whether the Constitution provides the President with a power to remove executive officials. The Constitution, however, undoubtedly gives Congress tools to discourage the President’s use of such power. Perhaps most notably, the Appointments Clause makes it more difficult for the President to remove principal officers—even those whose views are out of the step with the President’s—because the President cannot know whether the Senate will consent to a preferred replacement. This is an example of what we dub Congress’s anti-removal power: Even if the President can remove, a motivated Congress can discourage the President’s use …


A Review On Nanomaterials And Nanohybrids Based Bio-Nanocomposites For Food Packaging, Kalpani Y. Perera, Amit K. Jaiswal, Swarna Jaiswal Dec 2022

A Review On Nanomaterials And Nanohybrids Based Bio-Nanocomposites For Food Packaging, Kalpani Y. Perera, Amit K. Jaiswal, Swarna Jaiswal

Articles

With an increasing demand for a novel, eco-friendly, high-performance packaging material “bio-nanocomposites” has attracted great attention in recent years. The review article aims at to evaluating recent innovation in bio-nanocomposites for food packaging applications. The current trends and research over the last three years of the various bio-nanocomposites including inorganic, organic nanomaterials, and nanohybrids, which are suitable as food packaging materials due to their advanced properties such as high mechanical, thermal, barrier, antimicrobial, and antioxidant are described in detail. In addition, the legislation, migration studies, and SWOT analysis on bio-nanocomposite film have been discussed. It has been observed that the …


Studying With Dyslexia And Achieving In Partnership With It In Higher Education, Keith Murphy Dec 2022

Studying With Dyslexia And Achieving In Partnership With It In Higher Education, Keith Murphy

Articles

According to research by AHEAD (2021), students with specific learning difficulties (SLD) are accessing third level education in greater numbers than ever before. Within the body of research conducted few have focused on the overall experiences of students with dyslexia studying in third level education. The current study addresses this gap in knowledge as it provides an insight into how students with dyslexia, as an SLD, navigate third level education. Ethnography was used as the principal method of research in this project, and 17 participants, ranging in age from 20 years old to mid-40s years old, took part.

The research …


Enhancing The Wettability Of Polyetheretherketone (Peek) Membrane With Ozone For Improving Fuel Cell Performance, Hunter Heineman, Omran Omar, Benjamin Rippel, Ryan Keeley, Michael Mehan, Surendra K. Gupta, Gerald A. Takacs Dec 2022

Enhancing The Wettability Of Polyetheretherketone (Peek) Membrane With Ozone For Improving Fuel Cell Performance, Hunter Heineman, Omran Omar, Benjamin Rippel, Ryan Keeley, Michael Mehan, Surendra K. Gupta, Gerald A. Takacs

Articles

Ozone was reacted with the aromatic membrane polyetheretherketone (PEEK) to form oxidized functional groups on the surface to enhance the attraction and transport of protons in fuel cells. Ozonation of unsaturated C-C sp2 bonds in PEEK formed a primary ozonide which dissociated to primarily produce O=C-O/O=C-OH moieties, and the root mean squared roughness factor (Rq) decreased from 7.4 nm, for the untreated sample, down to 3.1 nm. The oxidation of the surface and decrease in surface roughness made the surface increase in hydrophilicity as observed by the decrease in the water contact angle (CA) from 80.3° for untreated PEEK down …


The Interaction Of Normalisation And Clustering In Sub-Domain Definition For Multi-Source Transfer Learning Based Time Series Anomaly Detection, Matthew Nicholson, Rahul Agrahari, Clare Conran, Haythem Assem, John D. Kelleher Dec 2022

The Interaction Of Normalisation And Clustering In Sub-Domain Definition For Multi-Source Transfer Learning Based Time Series Anomaly Detection, Matthew Nicholson, Rahul Agrahari, Clare Conran, Haythem Assem, John D. Kelleher

Articles

This paper examines how data normalisation and clustering interact in the definition of sub-domains within multi-source transfer learning systems for time series anomaly detection. The paper introduces a distinction between (i) clustering as a primary/direct method for anomaly detection, and (ii) clustering as a method for identifying sub-domains within the source or target datasets. Reporting the results of three sets of experiments, we find that normalisation after feature extraction and before clustering results in the best performance for anomaly detection. Interestingly, we find that in the multi-source transfer learning scenario clustering on the target dataset and identifying subdomains in the …


Cold Plasma Technology In Food Packaging, Kalpani Y. Perera, Jack Prendeville, Amit K. Jaiswal, Swarna Jaiswal Dec 2022

Cold Plasma Technology In Food Packaging, Kalpani Y. Perera, Jack Prendeville, Amit K. Jaiswal, Swarna Jaiswal

Articles

Cold plasma (CP) is an effective strategy to alter the limitations of biopolymer materials for food packaging applications. Biopolymers such as polysaccharides and proteins are known to be sustainable materials with excellent film-forming properties. Bio-based films can be used as an alternative to traditional plastic packaging. There are limitations to biopolymer packaging materials such as hydrophobicity, poor barrier, and thermos-mechanical properties. For this reason, biopolymers must be modified to create a packaging material with the desired applicability. CP is an effective method to enhance the functionality and interfacial features of biopolymers. It etches the film surface allowing for better adhesion …


The Eudemonic And Hedonic Impacts Of Attending Live And Virtual Music And Art Events, Philippa Kirwan, Samantha Morris Dec 2022

The Eudemonic And Hedonic Impacts Of Attending Live And Virtual Music And Art Events, Philippa Kirwan, Samantha Morris

Articles

This paper examines the under-investigated well-being impacts of arts and music events attendance, in both a live and virtual capacity. Using eudaimonia and hedonia as a measure for well-being, three objectives were investigated; 1) Do live arts and music events meet attendees eudemonic and hedonic needs? 2) Do virtual arts and music events meet attendees eudemonic and hedonic needs? 3) How do live and virtual music and art events compare in meeting attendees eudemonic and hedonic needs? The study focused on attendee’s experiences having attended both live and virtual events. Using nine semi-structured interviews this research found that live music …


Determinants Of Innovation Outcomes: The Role Of Institutional Quality, Abhijit Sharma, Cristina Sousa, Richard Woodward Dec 2022

Determinants Of Innovation Outcomes: The Role Of Institutional Quality, Abhijit Sharma, Cristina Sousa, Richard Woodward

Articles

This paper uses unconditional quantile regression analysis to interrogate the effects of institutional quality on innovation outcomes. We assess important determinants of innovation such as property rights (including enforcement of intellectual property rights), human resources within R&D and high-technology exports. Regarding intellectual property rights, while most previous research focuses on patent strength (de jure or book law), we focus on de facto patent enforcement. Using data from the World Bank, the Heritage Foundation and a new patent enforcement index, we construct a panel of fifty countries covering 1998–2017. Our analysis reveals important new insights including the strongly negative impact …


State Digital Services Taxes: A Good And Permissible Idea (Despite What You Might Have Heard), Young Ran (Christine) Kim, Darien Shanske Dec 2022

State Digital Services Taxes: A Good And Permissible Idea (Despite What You Might Have Heard), Young Ran (Christine) Kim, Darien Shanske

Articles

Tax systems have been struggling to adapt to the digitalization of the economy. At the center of the struggles is taxing digital platforms, such as Google or Facebook. These immensely profitable firms have a business model that gives away “free” services, such as searching the web. The service is not really free; it is paid for by having the users watch ads and tender data. Traditional tax systems are not designed to tax such barter transactions, leaving a gap in taxation.

One response, pioneered in Europe, has been the creation of a wholly new tax to target digital platforms: the …


Changes In Depressive Symptoms, Perceived Stres, And Food Security Among Study Participants With Metabolic Syndrome During A Covid-19-Mandated Research Pause, Barbara A. Lohse, Anahi Ramirez, Jenna Hickey, Lisa Bailey-Davis, Betty Drees, Kevin S. Masters, Elizabeth H. Ruder, Nicole Trabold Dec 2022

Changes In Depressive Symptoms, Perceived Stres, And Food Security Among Study Participants With Metabolic Syndrome During A Covid-19-Mandated Research Pause, Barbara A. Lohse, Anahi Ramirez, Jenna Hickey, Lisa Bailey-Davis, Betty Drees, Kevin S. Masters, Elizabeth H. Ruder, Nicole Trabold

Articles

Introduction: This study explored how food security, perceived stress and mental health of persons with metabolic syndrome (MetS) changed in the COVID-19 pandemic.

Methods: An online survey was administered to persons enrolled in a 2-year lifestyle intervention trial to reverse metabolic syndrome at baseline; the survey was repeated during the COVID-19 pandemic. Outcomes were a change in depressive symptoms, perceived stress, and food security as measured by the Patient Health Questionnaire-8, Cohen Stress Scale, and USDA 10-item Food Security Screener. Changes in outcomes were analyzed with measures of association, paired t-test, repeated measures and independent t-test.

Results: Participants (n = …


Using Electronic Medical Record Data To Establish And Monitor The Distribution Of Refractive Errors, Sean Longwill, Michael Moore, Daniel Ian Flitcroft, James Loughman Nov 2022

Using Electronic Medical Record Data To Establish And Monitor The Distribution Of Refractive Errors, Sean Longwill, Michael Moore, Daniel Ian Flitcroft, James Loughman

Articles

Objective

To establish the baseline distribution of refractive errors and associated factors amongst a population that attended primary care optometry clinics.

Design

Retrospective cross sectional cohort study of electronic medical records (EMR).

Methods

Electronic medical record data was extracted from forty optometry clinics, representing a mix of urban and rural areas in Ireland. The analysis was confined to demographic and clinical data gathered over a sixty-month period between 2015 and 2019. Distribution rates were calculated using the absolute and relative frequencies of refractive error in the dataset, stratified for age and gender using the following definitions: high myopia ≤ -6.00 …


Moving From Access To Inclusion By Making Communication A Priority, Sara Schley, Marchetti E. Carol Nov 2022

Moving From Access To Inclusion By Making Communication A Priority, Sara Schley, Marchetti E. Carol

Articles

What does it mean to be a full participant in a faculty-student partnership? We tackled this question by considering disability identity and communication access as pivotal mindsets in facilitating not only pedagogical change in the college classroom, but also student transformation into change agents. Via a series of semester-long FLCs, we used a partnership model to develop strategies aimed at increasing interaction and inclusion in postsecondary courses (Schley et al., 2021). The student partners were all deaf or hard of hearing (DHH), with a diverse set of communication preferences. Faculty partners were also diverse: some were DHH though most were …


An Exploration Of Recent Intelligent Image Analysis Techniques For Visual Pavement Surface Condition Assessment., Waqar Shahid Qureshi, Ibrahim Hassan Syed, Susan Mckeever, David Power, Brian Mulry, Kieran Feighan, Dympna O'Sullivan Nov 2022

An Exploration Of Recent Intelligent Image Analysis Techniques For Visual Pavement Surface Condition Assessment., Waqar Shahid Qureshi, Ibrahim Hassan Syed, Susan Mckeever, David Power, Brian Mulry, Kieran Feighan, Dympna O'Sullivan

Articles

Road pavement condition assessment is essential for maintenance, asset management, and budgeting for pavement infrastructure. Countries allocate a substantial annual budget to maintain and improve local, regional, and national highways. Pavement condition is assessed by measuring several pavement characteristics such as roughness, surface skid resistance, pavement strength, deflection, and visual surface distresses. Visual inspection identifies and quantifies surface distresses, and the condition is assessed using standard rating scales. This paper critically analyzes the research trends in the academic literature, professional practices and current commercial solutions for surface condition ratings by civil authorities. We observe that various surface condition rating systems …


Masculinities And Affective Equality; The Case Of Professional Caring, Niall Hanlon Nov 2022

Masculinities And Affective Equality; The Case Of Professional Caring, Niall Hanlon

Articles

Critical studies of men and masculinities [CSMM] aim to advance gender equality by critiquing and deconstructing male hegemony and hegemonic masculinities. Although the implicit value of gender equality is clear in CSMM generally, the conceptualization of equality is frequently vague, implied, and lacks conceptual definition. The problem is compounded in caring masculinities studies which additionally often lack engagement with critical feminist and other socio-political perspectives on caring. These shortcomings hide the complex interrelation of different dimensions to inequality as they intersect with multiple relational identities. Caring practices are also complex having distinct phases that engage different forms of labour within …


A Review Of Risk Concepts And Models For Predicting The Risk Of Primary Stroke, Elizabeth Hunter, John D. Kelleher Nov 2022

A Review Of Risk Concepts And Models For Predicting The Risk Of Primary Stroke, Elizabeth Hunter, John D. Kelleher

Articles

Predicting an individual's risk of primary stroke is an important tool that can help to lower the burden of stroke for both the individual and society. There are a number of risk models and risk scores in existence but no review or classification designed to help the reader better understand how models differ and the reasoning behind these differences. In this paper we review the existing literature on primary stroke risk prediction models. From our literature review we identify key similarities and differences in the existing models. We find that models can differ in a number of ways, including the …


The Smart Dementia Care Project, Dympna O'Sullivan, Jonathan Turner, Ciaran Nugent, Damon Berry, Michael Wilson, Julie Doyle Nov 2022

The Smart Dementia Care Project, Dympna O'Sullivan, Jonathan Turner, Ciaran Nugent, Damon Berry, Michael Wilson, Julie Doyle

Articles

No abstract provided.


Sodium Alginate, Nanoclay And Curcumin Based Food Packaging Material For Intelligent Food Packaging Applications, Kalpani Y. Perera, Máille Hopkins, Shubham Sharma, Brendan Duffy, Amit K. Jaiswal, Swarna Jaiswal Nov 2022

Sodium Alginate, Nanoclay And Curcumin Based Food Packaging Material For Intelligent Food Packaging Applications, Kalpani Y. Perera, Máille Hopkins, Shubham Sharma, Brendan Duffy, Amit K. Jaiswal, Swarna Jaiswal

Articles

Bionanocomposite food packaging contains materials of biological origin which display high-performance activity when compared to biopolymers and are eco-friendly alternatives to conventional packaging materials. Intelligent packaging monitors the condition of the food or environment surrounding the food and communicates changes to the consumer. This study aimed to develop a bionanocomposite intelligent packaging material by utilising sodium alginate, nanoclay and curcumin. Sodium alginate (2 W/V% SA) film incorporated with 0.3 W/V% curcumin (Cur), glycerol, and nanoclay (NC) in various concentrations (0, 0.5, 1 and 2 W/V %) was prepared using the solvent casting method. The influences of nanoclay and curcumin on …


Open-Source Clinical Machine Learning Models: Critical Appraisal Of Feasibility, Advantages, And Challenges, Keerthi B. Harish, W. Nicholson Price Ii, Yindalon Aphinyanaphongs Nov 2022

Open-Source Clinical Machine Learning Models: Critical Appraisal Of Feasibility, Advantages, And Challenges, Keerthi B. Harish, W. Nicholson Price Ii, Yindalon Aphinyanaphongs

Articles

Machine learning applications promise to augment clinical capabilities and at least 64 models have already been approved by the US Food and Drug Administration. These tools are developed, shared, and used in an environment in which regulations and market forces remain immature. An important consideration when evaluating this environment is the introduction of open-source solutions in which innovations are freely shared; such solutions have long been a facet of digital culture. We discuss the feasibility and implications of open-source machine learning in a health care infrastructure built upon proprietary information. The decreased cost of development as compared to drugs and …


Inclusion And Belonging In Irish Higher Education For Black And Minority Ethnic Students, Fionnuala Darby Nov 2022

Inclusion And Belonging In Irish Higher Education For Black And Minority Ethnic Students, Fionnuala Darby

Articles

Using Critical Race Theory (CRT) as an analytical prism, this study interrogates the sense of belonging and inclusion experienced by Black and Minority Ethnic (BME) students on one higher education campus in Ireland. The most important story told within the study is as simple as it is complicated. The simple part is that the BME students felt that the campus was inclusive and that they experienced a sense of belonging. The complicated part is that the findings are premised in a normative assumption of whiteness as evidenced by numerous and incremental moments of exclusion in the daily experience of microaggressions, …


An Evidence Review Of Behavioural Economics In The Justice Sector, Brian Barry, Lucia Morales, Aiden Carthy Nov 2022

An Evidence Review Of Behavioural Economics In The Justice Sector, Brian Barry, Lucia Morales, Aiden Carthy

Articles

Behavioural economics combines elements of economics and psychology to better understand how and why people behave the way they do in the real world. While behavioural economics originally sought to better understand economic decision-making, it has since grown in scope and application, and it is increasingly used by governments, government departments and other organisations to shape and implement public policies in a range of policy areas. This Review considers the application of behavioural economics theories and concepts (commonly referred to as behavioural insights) to the justice sector in a range of areas of justice policy in different jurisdictions. Areas of …


Cognitive Effort Avoidance In Veterans With Suicide Attempt Histories, James M. Bjork, Chelsea S. Rooney, Lisa K. Straub, David M. N. Garavito, Andrew Westbrook Nov 2022

Cognitive Effort Avoidance In Veterans With Suicide Attempt Histories, James M. Bjork, Chelsea S. Rooney, Lisa K. Straub, David M. N. Garavito, Andrew Westbrook

Articles

Suicide attempts (SA) are increasing in the United States, especially in veterans. Discovering individual cognitive features of the subset of suicide ideators who attempt suicide is critical. Cognitive theories attribute SA to facile schema-based negative interpretations of environmental events. Over-general autobiographical memory and facile solutions in problem solving tasks in SA survivors suggest that aversion to expending cognitive effort may be a neurobehavioral marker of SA risk. In veterans receiving care for mood disorder, we compared cognitive effort discounting and evidence-gathering in a beads task between veterans with (SAHx+; n = 26) versus without (SAHx-; n = 22) a history …


Due Process Alignment In Mass Restructurings, Sergio J. Campos, Samir D. Parikh Nov 2022

Due Process Alignment In Mass Restructurings, Sergio J. Campos, Samir D. Parikh

Articles

Mass tort defendants have recently begun exiting multidistrict litigation by filing for bankruptcy. This new strategy ushers defendants into a far more hospitable forum that offers accelerated resolution of all state and federal claims held by both current and future victims.

Bankruptcy's structural, procedural, and substantive benefits also provide defendants with unique optionality. Bankruptcy's resolution promise is alluring, but the process relies on a very large assumption: that future victims can be compelled to relinquish property rights in their cause of action against the corporate defendant and others without consent or notice. Bankruptcy builds an entire resolution structure on the …


Ignition Improvers For Aqueous Ammonia As Marine Fuel, Alessandro Schönborn, Kang-Ki Lee Nov 2022

Ignition Improvers For Aqueous Ammonia As Marine Fuel, Alessandro Schönborn, Kang-Ki Lee

Articles

The potential of three molecules NH4NO2, H2O2, and O3 to ignite aqueous solutions of ammonia (25% by mass) as fuel, was investigated using chemical kinetic simulations at conditions representative of a two-stroke marine diesel engine. The purpose was to address two of the most prominent issues with making ammonia a practical fuel for marine applications: the difficulty of igniting ammonia, and the safety concerns regarding its volatility and toxicity. The ignition simulations carried out to this end used a two-zone reactor model of the engine, representing the ignition zone into which fuel was injected, and the bulk cylinder gases, respectively. …


Advances In 3d Culture Systems For Therapeutic Discovery And Development In Brain Cancer, Janith Wanigasekara, Patrick J. Cullen, Paula Bourke, Brijesh Tiwari, James F. Curtin Nov 2022

Advances In 3d Culture Systems For Therapeutic Discovery And Development In Brain Cancer, Janith Wanigasekara, Patrick J. Cullen, Paula Bourke, Brijesh Tiwari, James F. Curtin

Articles

This review focuses on recent advances in 3D culture systems that promise more accurate therapeutic models of the glioblastoma multiforme (GBM) tumor microenvironment (TME), such as the unique anatomical, cellular, and molecular features evident in human GBM. The key components of a GBM TME are outlined, including microbiomes, vasculature, extracellular matrix (ECM), infiltrating parenchymal and peripheral immune cells and molecules, and chemical gradients. 3D culture systems are evaluated against 2D culture systems and in vivo animal models. The main 3D culture techniques available are compared, with an emphasis on identifying key gaps in knowledge for the development of suitable platforms …


Just Say No? Shareholder Voting On Securities Class Actions, Albert H. Choi, Stephen J. Choi, Adam C. Pritchard Oct 2022

Just Say No? Shareholder Voting On Securities Class Actions, Albert H. Choi, Stephen J. Choi, Adam C. Pritchard

Articles

The U.S. securities laws allow security-holders to bring a class action suit against a public company and its officers who make materially misleading statements to the market. The class action mechanism allows individual claimants to aggregate their claims. This procedure mitigates the collective action problem among claimants, and also creates potential economies of scale. Despite these efficiencies, the class action mechanism has been criticized for being driven by attorneys and also encouraging nuisance suits. Although various statutory and doctrinal solutions have been proposed and implemented over the years, the concerns over the agency problem and nuisance suits persist. This paper …