Digital Commons Network^™

Β-Glucosidase From Streptomyces Griseus: Ester Hydrolysis And Alkyl Glucoside Synthesis In The Presence Of Deep Eutectic Solvents, Albert Uhoraningoga, Gemma K. Kinsella, Gary T. Henehan, Barry J. Ryan

Articles

Deep Eutectic Solvents (DES) are ionic liquid analogs that have attracted considerable attention as green solvents for biocatalytic transformations. The use of DES as part of a ‘solvent engineering’ approach to enhance enzyme stability holds great promise since they are biodegradeable, relatively inexpensive and environmentally safe media for enzyme reactions. However, the behaviour of specific enzymes in such solvents is complex; some enzymes are inhibited in DES, while others appear to be activated.

Glucosidases are among the most widely used enzymes for commercial chemoenzymatic synthesis. In particular, their application in the synthesis of biodegradable alkyl glucosides by reverse hydrolysis is …

Temperature-Sensitive Holograms With Switchable Memory, Muhammad Irfan Dr, Suzanne Martin Dr, Izabela Naydenova Prof

Articles

Abstract

Herein, the dynamics and reversibility of temperature-induced changes in volume phase holographic gratings (VPHGs) recorded in the low-toxicity self-processing photopolymer poly(N-isopropyl acrylamide) (poly-NIPA) are reported on. Transmission and reflection gratings are exposed to temperatures ranging 8–60 °C to study the effect of temperature on their properties. First, the role of the photopolymer chemical composition is investigated by comparing layers containing NIPA with those containing acrylamide (AA) and measuring the normalized diffraction efficiency (DE) at 60 °C; higher thermal sensitivity is observed for poly-NIPA gratings (24% drop) versus low sensitivity for AA gratings (2% increase). The impact of …

An Lpc Pole Processing Method For Enhancing The Identification Of Dominant Spectral Features, Jin Xu, Mark Davis, Ruairí De Fréin

Articles

This paper proposes a new time-resolved spectral analysis method based on a modification to the linear predictive coding (LPC) method for enhancing the identification of the dominant frequencies of a signal. The method described here is based on a z-plane analysis of the LPC poles. These poles are used to produce a series of reduced order filter transfer functions which can accurately identify and estimate the frequency of the dominant spectral features. The standard LPC method has been shown to suffer from a sensitivity to noise and its performance is dependent on the filter order. The proposed method can …

Internet Of Medical Things (Iomt): Overview, Emerging Technologies, And Case Studies, Sahshanu Razdan, Sachin Sharma

Articles

No abstract provided.

Unveiling Women’S Needs And Expectations As Users Of Bike Sharing Services: The H2020 Diamond Project, Andrea Gorrini, Rawad Choubassi, Federico Messa, Wafaa Saleh, Augustus Ababio-Donkor, Maria Chiara Leva, Lorraine D'Arcy, Francesco Fabbri, David Laniado, Pablo Aragon

Articles

Within the objectives of the H2020 DIAMOND project, the paper investigates women’s needs and expectations as users of the bike-sharing service managed by Syndicat Mixte Autolib et Velib Métropole in the territory of Paris Region-Petite Couronne (France). The paper presents a thematic literature review focused on gender inclusion in bike-sharing schemes. The proposed methodological approach is based on (i) Geographic Information Systems for the analysis of geolocated open datasets related to land, sociodemographic and mobility characteristics of the areas surrounding each docking stations. This was aimed at identifying a short list of suitable bike-sharing docking stations, which were further characterized …

U-251mg Spheroid Generation Using A Scaffold Based Method Protocol, Lara Carroll, Brijesh K. Tiwari, James F. Curtin, Janith Wanigasekara

Articles

3D cell culture is a technique that is used to grow cells in vitro that will mimic an in vivo environment. 3D cell models are a helpful learning tool for researchers to better understand disease mechanisms and to explore different therapeutic properties of drugs. 3D cell cultures can be developed using patient derived cancer cells. Once they have been grown, these 3D cells can be used to screen for small molecule drugs or for genetic modification in for analysis of disease pathways or to predict drug treatments toxicity or efficacy. 3D cell cultures are a big step towards the more …

Mining And Managing Big Data Refactoring For Design Improvement: Are We There Yet?, Eman Abdullah Alomar, Mohamed Wiem Mkaouer, Ali Ouni

Articles

Refactoring is a set of code changes applied to improve the internal structure of a program, without altering its external behavior. With the rise of continuous integration and the awareness of the necessity of managing technical debt, refactoring has become even more popular in recent software builds. Recent studies indicate that developers often perform refactorings. If we consider all refactorings performed across all projects, this consists of the refactoring knowledge that represents a rich source of information that can be useful for both developers and practitioners to better understand how refactoring is being applied in practice. However, mining, processing, and …

Refactoring Practices In The Context Of Modern Code Review: An Industrial Case Study At Xerox, Eman Abdullah Alomar, Hussein Alrubaye, Mohamed Wiem Mkaouer, Ali Ouni, Marouane Kessentini

Articles

Modern code review is a common and essential 2 practice employed in both industrial and open-source projects 3 to improve software quality, share knowledge, and ensure con4 formance with coding standards. During code review, developers 5 may inspect and discuss various changes including refactoring 6 activities before merging code changes in the code base. To date, 7 code review has been extensively studied to explore its general 8 challenges, best practices and outcomes, and socio-technical 9 aspects. However, little is known about how refactoring activities 10 are being reviewed, perceived, and practiced. 11 This study aims to reveal insights into …

Finding The Needle In A Haystack: On The Automatic Identification Of Accessibility User Reviews, Eman Abdullah Alomar, Wajdi Aljedaani, Murtaza Tamjeed, Mohamed Wiem Mkaouer, Yasime Elglaly

Articles

In recent years, mobile accessibility has become an important trend with the goal of allowing all users the possibility of using any app without many limitations. User reviews include insights that are useful for app evolution. However, with the increase in the amount of received reviews, manually analyzing them is tedious and time-consuming, especially when searching for accessibility reviews. The goal of this paper is to support the automated identification of accessibility in user reviews, to help technology professionals in prioritizing their handling, and thus, creating more inclusive apps. Particularly, we design a model that takes as input accessibility user …

A Systematic Review Of Urban Navigation Systems For Visually Impaired People, Fatmaelzahraa Eltaher Ph.D, Ayman Taha, Jane Courtney, Susan Mckeever

Articles

Blind and Visually impaired people (BVIP) face a range of practical difficulties when undertaking outdoor journeys as pedestrians. Over the past decade, a variety of assistive devices have been researched and developed to help BVIP navigate more safely and independently. In~addition, research in overlapping domains are addressing the problem of automatic environment interpretation using computer vision and machine learning, particularly deep learning, approaches. Our aim in this article is to present a comprehensive review of research directly in, or relevant to, assistive outdoor navigation for BVIP. We breakdown the navigation area into a series of navigation phases and tasks. We …

Using Colorthink And Online Teaching, Robert Chung

Articles

The author taught many years of color reproduction-related courses to college students in print media and graphic communication programs. He used to think that hands-on lab assignment was only possible in-person in laboratory settings. His recent online teaching experiences proved him wrong. This document describes a lab assignment, Using ColorThink, in an online course, administered by Wuhan University, in the summer of 2020. Due to the coronavirus pandemic, no one was on campus. All eleven students were spread out across many provinces in China. As an adjunct instructor, located in North America, the author was able to connect with his …

The Role Of Rejuvenators In Embedded Damage Healing For Asphalt Pavement, Shi Xu, Xueyan Liu, Amir Tabakovic, P Lin, Y Zhang, S Nahar, B J. Lommerts, Erik Schlangen

Articles

Rejuvenator encapsulation technique showed great potential for extrinsic asphalt pavement damage healing. Once the capsules are embedded within asphalt pavement, the healing is activated on-demand via progressing microcrack. When the microcrack encounters the capsule, the fracture energy at the tip opens the capsule and releases the rejuvenator. Then the released rejuvenator wets the crack surfaces, diffuses into and softens the aged bitumen, allowing two broken edges to come in the contact, preventing further asphalt pavement deterioration. The quality and speed of the damage repair process strongly depend on the quality of rejuvenator, thus it is important to choose a proper …

Digital Gatekeepers, Thomas E. Kadri

Articles

If in William Blackstone's time we might have thought of a person's home as their castle, in Mark Zuckerberg's time we might say that their website is too.  Under cyber-trespass laws like the Computer Fraud and Abuse Act, courts have treated online platforms as digital gatekeepers--as property owners that may permit and restrict access to websites much like landowners may do with private land in the real world. If platforms withhold their consent through words or inference, cyber-trespass laws let them enforce their preferences about who may access their services and gather information from the internet. Concerned about reputations and …

Pathways To Institutional Transformation At Hbcus: Recommendations From Hbcu Black Women Stem Faculty, Anna Lee, Maya Corneille, Karen T. Jackson, Bahby Banks, Sherrice Allen

Articles

Black women STEM faculty at historically Black colleges and universities (HBCUs) experience many barriers to promotion, tenure, and the attainment of leadership positions. Institutional transformation is essential in addressing these inequities. However, there is a lack of literature that addresses the pathways for institutional transformation at HBCUs. The purpose of this paper is to share Black women STEM faculty from HBCUs recommendations for institutional transformation. Inter-views were conducted with fifteen Black women STEM faculty at HBCUs. Find-ings revealed several themes including the need for: (1) institutional accountability and oversight, (2) investment in the representation of Black women in faculty and …

Virtual Network Function Embedding Under Nodal Outage Using Deep Q-Learning, Swarna Bindu Chetty, Hamed Ahmadi, Sachin Sharma, Avishek Nag

Articles

With the emergence of various types of applications such as delay-sensitive applications, future communication networks are expected to be increasingly complex and dynamic. Network Function Virtualization (NFV) provides the necessary support towards efficient management of such complex networks, by virtualizing network functions and placing them on shared commodity servers. However, one of the critical issues in NFV is the resource allocation for the highly complex services; moreover, this problem is classified as an NP-Hard problem. To solve this problem, our work investigates the potential of Deep Reinforcement Learning (DRL) as a swift yet accurate approach (as compared to integer linear …

The Prospect Of Microwave Heating: Towards A Faster And Deeper Crack Healing In Asphalt Pavement, Shi Xu, Xueyan Liu, Amir Tabakovic, Erik Schlangen

Articles

Microwave heating has been shown to be an effective method of heating asphalt concrete and in turn healing the damage. As such, microwave heating holds great potential in rapid (1–3 min) and effective damage healing, resulting in improvement in the service life, safety, and sustainability of asphalt pavement. This study focused on the microwave healing effect on porous asphalt concrete. Steel wool fibres were incorporated into porous asphalt to improve the microwave heating efficiency, and the optimum microwave heating time was determined. Afterwards, the microwave healing efficiency was evaluated using a semi–circular bending and healing programme. The results show that …

Identifying Predictors Of Peripheral Intravenous Catheter Failure Using A Novel Combination Of Clinical And Ultrasonographic Assessments, Amit Bahl, Steven Johnson, Nicholas Mielke, Patrick Karabon

Articles

No abstract provided.

Towards A Blockchain Assisted Patient Owned System For Electronic Health Records, Tomilayo Fatokun, Avishek Nag, Sachin Sharma

Articles

Security and privacy of patients’ data is a major concern in the healthcare industry. In this paper, we propose a system that activates robust security and privacy of patients’ medical records as well as enables interoperability and data exchange between the different healthcare providers. The work proposes the shift from patient’s electronic health records being managed and controlled by the healthcare industry to a patient-centric application where patients are in control of their data. The aim of this research is to build an Electronic Healthcare Record (EHR) system that is layered on the Ethereum blockchain platform and smart contract in …

Diagnostics Of A Large Volume Pin-To-Plate Atmospheric Plasma Source For The Study Of Plasma Species Interactions With Cancer Cell Cultures, Laurence Scally, Chaitanya Sarangapani, Brijesh Tiwari, Renee Malone, Hugh Byrne, James Curtin, P.J. Cullen

Articles

A large gap pin-to-plate, atmospheric pressure plasma reactor is demonstrated as means of in vitro study of plasma species interactions with cell cultures. By employing optical emission and optical absorption spectroscopy, we report that the pin-to-pate plasma array had an optimal discharge frequency for cell death of 1000 Hz in ambient air for the target cancer cell line; human glioblastoma multiform (U-251MG). The detected plasma chemistry contained reactive oxygen and nitrogen species including OH, N₂, N₂⁺, and O₃. We show that, by varying the plasma discharge frequency, the plasma chemistry can be tailored …

Acknowledgements As A Window Into Legal Academia, Jonathan Tietz, W. Nicholson Price Ii

Articles

Legal scholarship in the United States is an oddity—an institution built on student editorship, a lack of peer review, and a dramatically high proportion of solo authorship. It is often argued that this makes legal scholarship fundamentally different from scholarship in other fields, which is largely peer-reviewed by academics. We use acknowledgments in biographical footnotes from law review articles to probe the nature of legal knowledge co-production and de facto peer review in the legal literature. Using a survey and a textual analysis of about thirty thousand law review articles from 2008 to 2017, we examined the nature of knowledge …

Antitrust Antitextualism, Daniel A. Crane

Articles

Judges and scholars frequently describe antitrust as a common-law system predicated on open-textured statutes, but that description fails to capture a historically persistent phenomenon:judicial disregard of the plain meaning of the statutory texts and manifest purposes of Congress. This pattern of judicial nullification is not evenly distributed: when the courts have deviated from the plain meaning or congressional purpose, they have uniformly done so to limit the reach of antitrust liability or curtail the labor exemption to the benefit of industrial interests. This phenomenon cannot be explained solely or even primarily as a tug-of-war between a progressive Congress and conservative …

Delegation At The Founding, Julian Davis Mortenson, Nicholas Bagley

Articles

This article refutes the claim that the Constitution was originally understood to contain a nondelegation doctrine. The founding generation didn’t share anything remotely approaching a belief that the constitutional settlement imposed restrictions on the delegation of legislative power---let alone by empowering the judiciary to police legalized limits. To the contrary, the overwhelming majority of Founders didn’t see anything wrong with delegations as a matter of legal theory. The formal account just wasn’t that complicated: Any particular use of coercive rulemaking authority could readily be characterized as the exercise of either executive or legislative power, and was thus formally valid regardless …

Deployment And Control Of Adaptive Building Facades For Energy Generation, Thermal Insulation, Ventilation And Daylighting: A Review, Hani Alkhatib, Philippe Lemarchand, Brian Norton, Dominic O'Sullivan

Articles

A major objective in the design and operation of buildings is to maintain occupant comfort without incurring significant energy use. Particularly in narrower-plan buildings, the thermophysical properties and behaviour of their façades are often an important determinant of internal conditions. Building facades have been, and are being, developed to adapt their heat and mass transfer characteristics to changes in weather conditions, number of occupants and occupant’s requirements and preferences. Both the wall and window elements of a facade can be engineered to (i) harness solar energy for photovoltaic electricity generation, heating, inducing ventilation and daylighting (ii) provide varying levels of …

Impact Of Dynamic Sub-Populations Within Grafted Chains On The Protein Binding And Colloidal Stability Of Pegylated Nanoparticles, Delyan Hristov, Hender Lopez, Yannick Ortin, Kate O'Sullivan, Kenneth A. Dawson, Dermot F. Brougham

Articles

Polyethylene glycol grafting has played a central role in preparing the surfaces of nano-probes for biological interaction, to extend blood circulation times and to modulate protein recognition and cellular uptake. However, the role of PEG graft dynamics and conformation in determining surface recognition processes is poorly understood primarily due to the absence of a microscopic picture of the surface presentation of the polymer. Here a detailed NMR analysis reveals three types of dynamic ethylene glycol units on PEG-grafted SiO2 nanoparticles (NPs) of the type commonly evaluated as long-circulating theranostic nano-probes; a narrow fraction with fast dynamics associated with the chain …

Noncompete Agreements In The U.S. Labor Force, Evan P. Starr, J.J. Prescott, Norman D. Bishara

Articles

Using nationally representative survey data on 11,505 labor force participants, we examine the use and implementation of noncompete agreements and the employee outcomes associated with these provisions. Approximately 18 percent of labor force participants are bound by noncompetes, with 38 percent having agreed to at least one in the past. Noncompetes are more likely to be found in high-skill, high-paying jobs, but they are also common in low-skill, low-paying jobs and in states where noncompetes are unenforceable. Only 10 percent of employees negotiate over their noncompetes, and about one-third of employees are presented with noncompetes after having already accepted job …

The International Convention For The Safety Of Life At Sea: Highlighting Interrelations Of Measures Towards Effective Risk Mitigation, Anish Joseph, Dimitrios Dalaklis

Articles

Safety is often described as freedom from unacceptable risk. The International Maritime Organization (IMO) since its establishment has consistently been working towards mitigation of risks at sea by implementing measures through specific legal Instruments. The IMO’s principle Instrument with this focus is the International Convention for the Safety of Life at Sea, 1974, as amended (SOLAS). By identifying and examining a wide range of risks that must be addressed in order to ensure the safe operations of ships at sea, the chapters of SOLAS provide the necessary mitigation measures. This paper goes on to discusses three specific risks among those …

Review Of Current Healthcare Waste Management Methods And Their Effect On Global Health, Anushree Priyadarshini, Christina Kenny

Articles

Healthcare is a rapidly growing industry as medical treatments become more sophisticated, more in demand due to increasing incidence of chronic disease and more widely available worldwide. This booming industry is also creating more waste than ever before and, as such, there is a growing need to treat and dispose of this waste. Healthcare waste (HCW) disposal includes a multitude of disposal methods, including incineration, landfilling and chemical treatments. These rudimentary methods and their growing use present their own problems that negatively impact both the environ- ment and, in turn, damage public health, thus contributing to a global healthcare crisis. …

Synergies In Scholarship At The Research Teaching Nexus, Deirdre Mcquillan

Articles

Survey instrument for examining research synergies in scholarship at the research teaching nexus

The Effect Of Pressure Fluctuations On The Shapes Of Thinning Liquid Curtains, Bridget M. Torsey, Steven J. Weinstein, David S. Ross, Nathaniel S. Barlow

Articles

We consider the time-dependent response of a gravitationally thinning inviscid liquid sheet (a coating curtain) leaving a vertical slot to sinusoidal ambient pressure disturbances. The theoretical investigation employs the hyperbolic partial differential equation developed by Weinstein et al. (Phys. Fluids, vol. 9, issue 12, 1997, pp. 3625–3636). The response of the curtain is characterized by the slot Weber number, We0=ρqV/2σ" role="presentation" style="box-sizing: border-box; margin: 0px; padding: 0px; border: 0px; font-variant: inherit; font-stretch: inherit; line-height: normal; font-family: inherit; vertical-align: baseline; display: inline-table; word-spacing: normal; overflow-wrap: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; position: …

Examining The Modelling Capabilities Of Defeasible Argumentation And Non-Monotonic Fuzzy Reasoning, Luca Longo, Lucas Rizzo, Pierpaolo Dondio

Articles

Knowledge-representation and reasoning methods have been extensively researched within Artificial Intelligence. Among these, argumentation has emerged as an ideal paradigm for inference under uncertainty with conflicting knowledge. Its value has been predominantly demonstrated via analyses of the topological structure of graphs of arguments and its formal properties. However, limited research exists on the examination and comparison of its inferential capacity in real-world modelling tasks and against other knowledge-representation and non-monotonic reasoning methods. This study is focused on a novel comparison between defeasible argumentation and non-monotonic fuzzy reasoning when applied to the representation of the ill-defined construct of human mental workload …