Digital Commons Network^™

Enhanced Fractional Adaptive Processing Paradigm For Power Signal Estimation, Naveed Ishtiaq Chaudhary, Zeshan Aslam Khan, Muhammad Asif Zahoor Raja, Iqra Ishtiaq Chaudhary

Articles

Fractional calculus tools have been exploited to effectively model variety of engineering, physics and applied sciences problems. The concept of fractional derivative has been incorporated in the optimization process of least mean square (LMS) iterative adaptive method. This study exploits the recently introduced enhanced fractional derivative based LMS (EFDLMS) for parameter estimation of power signal formed by the combination of different sinusoids. The EFDLMS addresses the issue of fractional extreme points and provides faster convergence speed. The performance of EFDLMS is evaluated in detail by taking different levels of noise in the composite sinusoidal signal as well as considering various …

Three-Dimensional (3d) In Vitro Cell Culture Protocols To Enhance Glioblastoma Research, Janith Wanigasekara, Lara Carroll, Patrick J. Cullen, Brijesh K. Tiwari, James Curtin

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Three-dimensional (3D) cell culture models can help bridge the gap between in vitro cell cultures and in vivo responses by more accurately simulating the natural in vivo environment, shape, tissue stiffness, stressors, gradients and cellular response while avoiding the costs and ethical concerns associated with animal models. The inclusion of the third dimension in 3D cell culture influences the spatial organization of cell surface receptors that interact with other cells and imposes physical restrictions on cells in compared to Two-dimensional (2D) cell cultures. Spheroids’ distinctive cyto-architecture mimics in vivo cellular structure, gene expression, metabolism, proliferation, oxygenation, nutrition absorption, waste excretion, …

Monitoring And Modelling The Glutamine Metabolic Pathway: A Review And Future Perspectives, Zohreh Mirveis, Paul Cahill, Nitin Patel, Hugh Byrne

Articles

In this review, the contribution of NMR to the metabolomics field will be discussed—particularly as it relates to cancer and drug metabolism research. An overview of the typical NMR metabolomic experiment will be presented while emphasizing important caveats ranging from experimental design to data interpretation.

Enhanced Gene Transfection Efficacy And Safety Through Granular Hydrogel Mediated Gene Delivery Process, Jing Zhang, Zhonglei He, Yinghao Li, Yu Shen, Guanfu Wu, Laura Power, Rijian Song, Ming Zeng, Xianqing Wang, Irene Lara Sáez, Sigen A, Qian Xu, James Curtin, Ziyi Yu, Wenxin Wang

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Although gene therapy has made great achievements in both laboratory research and clinical translation, there are still challenges such as limited control of drug pharmacokinetics, acute toxicity, poor tissue retention, insufficient efficacy, and inconsistent clinical translation. Herein, a gene therapy gel is formulated by directly redispersing polyplex nanoparticles into granular hydrogels without any gelation pre-treatment, which provides great convenience for storage, dosing and administration. In vitro studies have shown that use of granular hydrogels can regulate the gene drug release, reduce dose dependent toxicity and help improve transfection efficacy. Moreover, the developed gene therapy gel is easy to operate and …

Numeracy-Meets: An Innovative Professional Development Model For Adult Numeracy Practitioners In Ireland, Mark Prendergast, Annette Forster, Niamh O'Meara, Kathy O'Sullivan, Fiona Faulkner

Articles

Despite the clear and obvious need for adults to be proficient in numeracy, international studies suggest that many continue to struggle in this area. In Ireland, one of the main challenges continues to be the availability of effective adult numeracy education. This is a diverse sector, and little is known about the varied provision of adult numeracy courses and of those who teach on them. Recent research has highlighted an unmet demand for the professional development of adult numeracy practitioners with many looking for opportunities to network and further develop their practice. This study aimed to design, implement and evaluate …

Assessing Authentically – Learnings From Marketing Educators, S. Montano, L. Gill-Simmen, D. Lee, Lucia Walsh, Deirdre Duffy Dr, N. Newman

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This paper demonstrates the importance and role of authentic assessments, that replicate industry practice, within Higher Education marketing programmes. We answer the call from employers, that students need to gain much-needed employability skills, and we illustrate how such assessments can be created to enable the development of employability skills. We provide an overview of four case studies, to illustrate different forms of authentic assessments, the theory which was used to underpin the designs, the skills developed during the assessments, and the outcomes of the assessments. As we emerge from the COVID-19 pandemic, which forced a move to online assessments, it …

Machine-Learning-Based Head Impact Subtyping Based On The Spectral Densities Of The Measurable Head Kinematics, Xianghao Zhan, Yiheng Li, Yuzhe Liu, Nicholas J. Cecchi, Samuel J. Raymond, Zhou Zhou, Hossein Vahid Alizadeh, Jesse Ruan, Saeed Barbat, Stephen Tiernan, Olivier Gevaert, Michael M. Zeineh, Gerald A. Grant, David B. Camarillo

Articles

Traumatic brain injury can be caused by head impacts, but many brain injury risk estimation models are not equally accurate across the variety of impacts that patients may undergo and the characteristics of different types of impacts are not well studied. We investigated the spectral characteristics of different head impact types with kinematics classification. Methods: Data was analyzed from 3,262 head impacts from lab reconstruction, American football, mixed martial arts, and publicly available car crash data. A random forest classifier with spectral densities of linear acceleration and angular velocity was built to classify head impact types (e.g., football, car crash, …

Tio2-Mwcnt Nanohybrid: Cytotoxicity, Protein Corona Formation And Cellular Internalisation In Rtg-2 Fish Cell Line, Gabriela Helena Da Silva, Lidiane Silva Franqui, Marcelo A. De Farias, Vera Lucia S.S. De Castro, Hugh Byrne, Diego S.T. Martinez, Regina T.R. Monteiro, Alan Casey

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Titanium dioxide nanoparticles-multiwalled carbon nanotubes (TiO2-MWCNT) nanohydrid has an enhanced photocatalytic activity across the visible light with promising applications in environmental remediation, solar energy devices and antimicrobial technologies. However, it is necessary to evaluate the toxicological effects of TiO2-MWCNT towards safe and sustainable development of nanohybrids. In this work, we studied the cytotoxicity, protein corona formation and cellular internalisation of TiO2-MWCNT on fibroblasts derived from gonadal rainbow trout tissue (RTG-2) for the first time. This nanohydrid did not show any toxicity effect on RTG-2 cells up to 100 mg L-1 after 24 h of exposure as monitored by alamar blue, …

Know An Emotion By The Company It Keeps: Word Embeddings From Reddit/Coronavirus, Alejandro García-Rudolph, David Sanchez-Pinsach, Dietmar Frey, Eloy Opisso, Katryna Cisek, John Kelleher

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Social media is a crucial communication tool (e.g., with 430 million monthly active users in online forums such as Reddit), being an objective of Natural Language Processing (NLP) techniques. One of them (word embeddings) is based on the quotation, “You shall know a word by the company it keeps,” highlighting the importance of context in NLP. Meanwhile, “Context is everything in Emotion Research.” Therefore, we aimed to train a model (W2V) for generating word associations (also known as embeddings) using a popular Coronavirus Reddit forum, validate them using public evidence and apply them to the discovery of context for specific …

Rapid Detection Of Sars-Cov-2 Nucleocapsid Protein By A Label-Free Biosensor Based On Optical Fiber Cylindrical Micro-Resonator, Ru-Lei Xia, Bin Liu, Yingying Hu, Juan Liu, Yue Fu, Xing-Dao He, Ping Lu, Yingying Hu, Gerald Farrell

Articles

The current global outbreak of coronavirus (COVID-19) continues to be a severe threat to human health. Rapid, low-cost, and accurate antigen detection methods are very important for disease diagnosis. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) nucleocapsid protein (N-Protein) is often used as the diagnostic and screening for coronavirus detection. To this end, we propose and experimentally validate a highly sensitive whispering gallery mode (WGM) optical cylindrical micro-resonator (CMR) for bio immunoassay detection. To study the biokinetic process of immunoassay, the surface of the WGM micro-resonator is functionalized with N-Protein monoclonal antibody (N-Protein-m Ab), which led to the specific detection …

Comparative Simulations Of An Electrochromic Glazing And A Roller Blind As Controlled By Seven Different Algorithms, Hani Alkhatib, Philippe Lemarchand, Brian Norton, Dympna O'Sullivan

Articles

The use of roller blind as a surrogate for a switchable glazing in a dynamic building environmental simulation is investigated. Seven different control algorithms were applied to simulations of both operations of the blind and of the switchable glazing. The configurations compared were an electrochromic glazing and a roller blind, the controllers used were rule-based, proportional-integral-derivative (PID), anti-windup PID (a PID) and a model predictive controller (MPC). Particular case studies were examined in the weather conditions of Dublin, Ireland to make comparisons of simulated energy savings and occupancy daylight comfort from the use of electrochromic glazing or a roller blind …

Hmm, You Seem Confused! Tracking Interlocutor Confusion For Situated Task-Oriented Hri, Na Li, Robert J. Ross

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Our research seeks to develop a long-lasting and high-quality en- gagement between the user and the social robot, which in turn requires a more sophisticated alignment of the user and the system than is currently commonly available. Close monitoring of inter- locutors’ states, and we argue their confusion state in particular, and adjusting dialogue policies based on this state of confusion is needed for successful joint activity. In this paper, we present an ini- tial study of a human-robot conversation scenarios using a Pepper robot to investigate the confusion states of users. A Wizard-of-Oz (WoZ) HRI experiment is illustrated in …

Deregulation: Too Big For One Branch, But Maybe Not For Two, Stephen M. Johnson

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When President Trump took office in 2017, he pursued a deregulatory agenda that exceeded even that of President Reagan. Environmental rules and policies were a major target of the Administration. The President deployed a mix of traditional tools, such as executive orders, guidance documents and policies, and rulemaking to suspend or reverse longstanding regulations and policies of the Environmental Protection Agency (EPA), the Department of the Interior, and other environmental agencies. The Administration also utilized the Congressional Review Act as it had not been used before and aggressively sought abeyances in litigation challenging disfavored rules and policies to advance its …

Ar/Vr Teaching-Learning Experiences In Higher Education Institutions (Hei): A Systematic Literature Review, Belen Bermejo, Carlos Juiz, David Cortes, Jeroen Oskam, Teemu Moilanen, Jouko Loijas, Praneschen Govender, Jenniifer Hussey, Alexander Lennart Schmidt, Ralf Burbach, Daniel King, Colin O'Connor, David Dunlea

Articles

During the last few years, learning techniques have changed, both in basic education and in higher education. This change has been accompanied by new technologies such as Augmented Reality (AR) and Virtual Reality (AR). The combination of these technologies in education has allowed a greater immersion, positively affecting the learning and teaching processes. In addition, since the COVID-19 pandemic, this trend has been growing due to the diversity of the different fields of application of these technologies, such as heterogeneity in their combination and their different experiences. It is necessary to review the state of the art to determine the …

Virtual Industry Visits, Cian Farrell

Articles

Cian Farrell of Technological University Dublin describes a virtual educational approach trialled during the Covid-19 pandemic to engage students during a period of remote learning and educate them on industry processes and practices. Virtual industry visits saw students receive online briefings and tours of manufacturing plants and construction sites from industry representatives to complement their taught modules. The virtual visits have continued since Covid restrictions eased as part of a hybrid approach to learning that increases student exposure to real-life projects. The initiative won the Institution of Structural Engineers Excellence in Structural Engineering Education Award in 2022.

Feature Papers In Optical Sensors 2022, Vittorio M. N. Passaro, Yuliya Semenova, Benjamin Miller

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Today, optical sensors are the subject of a very significant number of studies and applications. Many well-established technologies, including free-space optics, integrated photonics, and fiber optics approaches, have been developed in recent decades to fabricate and develop increasingly more efficient optical sensors for applications ranging from industrial control to monitoring the environment, biomedical use, and even as part of the Internet of Things.

Deactivation Effects Of Tb3+ On Ho3+ Emission In Fluoroindate Glasses For 3.9 Μm Laser Applications, Zhi Zhang, Zhuowei Cheng, Ruicong Wang, Shunbin Wang, Gerald Farrell, Shijie Jia, Pengfei Wang

Articles

A series of Ho3+/Tb3+ co-doped fluoroindate glasses with good thermal stability have been synthesized to study the deactivation effects of Tb3+ on the Ho3+: 3.9 μm emission. Efficient 3.9 μm emission enhancement is obtained under excitation by an 888 nm laser diode (LD). The Judd-Ofelt (J-O) intensity parameters and radiative properties are calculated to evaluate the spectroscopic properties. Possible energy transfer processes resulting in emission reinforcement are discussed. A higher spontaneous transition probability and larger peak emission cross section are achieved with the inclusion of Tb3+. This analysis supports the conclusion that Ho3+/Tb3+ co-doped fluoroindate glass is a potentially useful …

High-Sensitivity Vector Bend Sensor Based On A Fiber Directional Coupler Inscribed By A Femtosecond Laser, Ke Tian, Mingyuan Zhang, Chuanzhein Zhao, Huibin Li, Shilong Li, Yuxuan Jiang, Gerald Farrell, Pengfei Wang

Articles

In this Letter, we demonstrate a high-sensitivity vector bend sensor based on a fiber directional coupler. The fiber directional coupler is composed of two parallel waveguides inscribed within a no-core fiber (NCF) by a femtosecond laser. Since the two written waveguides have closely matched refractive indices and geometries, the transmission spectrum of the fiber directional coupler possesses periodic resonant dips. Such a fiber directional coupler exhibits a good bending-dependent spectral shift response due to its asymmetric structure. Experimental results show that bending sensitivities of -97.11 nm/m-1 and 58.22 nm/m-1 are achieved for the 0° and 180° orientations in the curvature …

Efficient 2075-Nm Laser Emission From Ho3+-Doped Fluorotellurite Glass In A Compact All-Fiber Structure, Liyuan Wang, Xiaotong Zhao, Nian Lv, Niannian Xu, Zhenrui Li, Gerald Farrell, Shunbin Wang, Pengfei Wang

Articles

In this Letter, we report an Ho3+-doped fluorotellurite glass all-fiber laser at 2075 nm. The gain fiber is pumped in-band with a 1976-nm fiber laser and connected by fusion splicing. A high-quality fusion splicing point with a loss of < 0.1 dB was obtained by finely adjusting the splicing power and offset. In addition, by optimizing the writing parameters, a third-order fiber Bragg grating (FBG) with a reflectivity of 98% was achieved at 2075 nm using the femtosecond laser direct-writing method. Using the FBG as the laser cavity mirror and a relatively short 28-cm-long home-made Ho3+-doped fluorotellurite fiber as the laser medium, a laser with a maximum unsaturated output power of 7.33 W was obtained, and the corresponding slope efficiency was as high as 93.4%. The first, to the best of our knowledge, demonstration of the fluorotellurite glass all-fiber ∼2.1-µm laser presented in this work may pave the way for a high-power 2.1-µm fiber laser with a compact structure.

An “Essential” Solution: Reworking The Essential Facilities Doctrine To Address Big Tech’S Harm To The Marketplace Of Ideas, Kaleb Byars

Articles

Google’s mission statement is undoubtedly altruistic. The Internet overflows with information, and users could not navigate the Internet if an entity did not logically organize that information. On the other hand, should democratic societies accept the convenience that Google and the other Big Tech firms provide if that convenience impairs the marketplace of ideas? Big Tech censorship is at the forefront of current news and congressional consideration. At both ends of the political spectrum, parties agree

Big Tech censorship harms the marketplace of ideas. Republican congresspersons argue Big Tech supports liberal ideas and censors conservative voices, websites, and advertisements. Democratic …

Forecasting Covid-19 Cases Using Dynamic Time Warping And Incremental Machine Learning Methods, Luis Miralles-Pechuán, Ankit Kumar, Andres L. Suarez-Cetrulo

Articles

The investment of time and resources for developing better strategies is key to dealing with future pandemics. In this work, we recreated the situation of COVID-19 across the year 2020, when the pandemic started spreading worldwide. We conducted experiments to predict the coronavirus cases for the 50 countries with the most cases during 2020. We compared the performance of state-of-the-art machine learning algorithms, such as long-short-term memory networks, against that of online incremental machine learning algorithms. To find the best strategy, we performed experiments to test three different approaches. In the first approach (single-country), we trained each model using data …

Imi—Nonpathological Human Ocular Tissue Changes With Axial Myopia, Jost B. Jonus, Richard F. Spaide, Lisa A. Ostrin, Nicola S. Logan, Daniel Ian Flitcroft, Songhomitra Panda-Jonas

Articles

In axial myopia, the eye changes from a spherical shape to a prolate ellipsoid, photoreceptor, and retinal pigment epithelium cell density and total retinal thickness decrease, most marked in the retroequatorial region, followed by the equator. The choroid and sclera are thin, most markedly at the posterior pole and least markedly at the ora serrata. The sclera undergoes alterations in fibroblast activity, changes in extracellular matrix content, and remodeling. Bruch’s membrane (BM) thickness is unrelated to axial length, although the BM volume increases. In moderate myopia, the BM opening shifts, usually toward the fovea, leading to the BM overhanging into …

Modification Of Hyaluronic Acid To Enable Click Chemistry Photo-Crosslinking Of Hydrogels With Tailorable Degradation Profiles, Ciara Buckley

Articles

Hyaluronic acid (HA) is a naturally occurring mucopolysaccharide that, due to its inherent bioactivity and extracellular matrix-like structure, has the potential to be utilised extensively in tissue engineering. However, this glycosaminoglycan lacks the properties required for cellular adhesion and photo-crosslinking by UV light, which significantly hinders this polymers applicability. This research presents a method for modifying hyaluronic acid via thiolation and methacrylation to generate a novel photo-crosslinkable polymer with improved physicochemical properties, biocompatibility and the potential to customize biodegradability according to the ratio of monomers used. A decrease in stiffness proportional to increasing thiol concentration was observed when testing the …

The Use Of Transport Time Scales As Indicators Of Pollution Persistence In A Macro-Tidal Setting, Guanghai Gao, John J. O'Sullivan, Aisling Corkery, Zeinab Bedri, Gregory M.P. O'Hare, Wim G. Meijer

Articles

An understanding of water exchange processes is essential for assessing water quality management issues in coastal bays. This paper evaluates the impact of water exchange processes on pollution persistence in a macro-tidal semi-closed coastal bay through two transport time scales (TTS), namely residence time and exposure time. The numerical model was calibrated against field-measured data for various tidal conditions. Simulated current speeds and directions were shown to agree well with the field data. By considering different release scenarios of a conservative tracer by the refinement of an integrated hydrodynamic and solute transport model (the EFDC), the two TTS were used …

Thermoelectric Properties Of Cement Composite Analogues From First Principles Calculations, Esther Orisakwe, Conrad S.N. Johnston, Ruchita Jani, Xiaolo Liu, Lorenzo Stella, Jorge Kohanoff's, Niall Holmes Dr., Brian Norton, Ming Qu, Hongxi Yin, Kazuaki Yazawa

Articles

Buildings are responsible for a considerable fraction of the energy wasted globally every year, and as a result, excess carbon emissions. While heat is lost directly in colder months and climates, resulting in increased heating loads, in hot climates cooling and ventilation is required. One avenue towards improving the energy efficiency of buildings is to integrate thermoelectric devices and materials within the fabric of the building to exploit the temperature gradient between the inside and outside to do useful work. Cement-based materials are ubiquitous in modern buildings and present an interesting opportunity to be functionalized. We present a systematic investigation …

Recent Advances In Whiskey Analysis For Authentication, Discrimination, And Quality Control, Chioke A. Okolo, Kieran N. Kilcawley, Christine O'Connor

Articles

In order to safeguard authentic whiskey products from fraudulent or counterfeit practices, high throughput solutions that provide robust, rapid, and reliable solutions are required. The implementation of some analytical strategies is quite challenging or costly in routine analysis. Qualitative screening of whiskey products has been explored, but due to the nonspecificity of the chemical compounds, a more quantitative confirmatory technique is required to validate the result of the whiskey analysis. Hence, combining analytical and chemometric methods has been fundamental in whiskey sample differentiation and classification. A comprehensive update on the most relevant and current analytical techniques, including spectroscopic, chromatographic, and …

Characterisation Of Cartilage Damage Via Fusing Mid-Infrared, Near-Infrared, And Raman Spectroscopic Data, Rubina Shaikh Dr, Valeria Tafintseva, Ervin Nippolainen, Vesa Virtanen, Johanne Solheim, Boris Zimmermann, Simo Saarakkala, Juhu Toyras, Achim Kohler, Isaac O. Afara

Articles

Mid-infrared spectroscopy (MIR), near-infrared spectroscopy (NIR), and Raman spectroscopy are all well-established analytical techniques in biomedical applications. Since they provide complementary chemical information, we aimed to determine whether combining them amplifies their strengths and mitigates their weaknesses. This study investigates the feasibility of the fusion of MIR, NIR, and Raman spectroscopic data for characterising articular cartilage integrity. Osteochondral specimens from bovine patellae were subjected to mechanical and enzymatic damage, and then MIR, NIR, and Raman data were acquired from the damaged and control specimens. We assessed the capacity of individual spectroscopic methods to classify the samples into damage or control …

Review Of The International Play Policies And Their Contribution To Supporting A Child's Right To Play, Fiona Armstrong, David Gaul

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Play is recognised as a fundamental children's right protected by the United Nations Convention on the Rights of the Child. Despite legal and constitutional requirements for ensuring children's right to play, there are few international policies dedicated to play. This paper seeks to use a critical discourse analysis lens to compare the current international policies dedicated to play and identify examples of good practice and perceived barriers to the successful development and implementation of play policies.

Effect Of Operating Parameters On Performance Of Finger Millet Pearling Machine, Ranjit Powar, Vijay Aware, Prasad Chavan, Amit K. Jaiswal

Articles

The effect of operational parameters such as feed rate (FR), drum speed (DS), and concave clearance (CC) was studied on the performance of a pearling drum. The pearling drum consists of pearling cylinder, pearling sieve, concave, and outer casing of the drum. The response surface method with CCRD experimental design was used to study the effect of operational parameters on pearling drum. The considered levels for optimizing operational parameters viz., FR, DS, and CC were 40–80 kg/h, 5– 10 m/s, and 3–15 mm, respectively. The maximum pearling efficiency (PE) and minimum grain damage (GD) were found to be 98.40%, and …

Achieving Strong Chemical Interface And Superior Energy-Saving Capability At The Crosslinks Of Rubber Composites Containing Graphene Oxide Using Thiol-Vinyl Click Chemistry, Rui Zhang, Jiaye Li, Zongchao Xu, Stephen Jerrams, Shui Hu, Li Lui, Shipeng Wen, Liqun Zhang

Articles

Rapidly developments in international transportation inevitably lead to an increase in the consumption of energy and resources. Minimizing the rolling resistance of tires in this scenario is a pressing challenge. To lower the rolling resistance of tires, enhancing the interaction between fillers and rubber molecules while improving the dispersion of fillers are required to reduce the internal mutual friction and viscous loss of rubber composites. In this study, graphene oxide (GO) was modified using γ-mercaptopropyltrimethoxysilane (MPTMS) with thiol groups. A modified GO/natural rubber (MGO/NR) masterbatch with a fine dispersion of MGO was then introduced into solution-polymerized styrene butadiene rubber (SSBR) …