Digital Commons Network^™

Recent Applications Of Chemical Imaging To Pharmaceutical Process Monitoring And Quality Control, A. A. Gowen, Colm O'Donnell, Patrick J. Cullen, S. Bell

Articles

Chemical Imaging (CI) is an emerging platform technology that integrates conventional imaging and spectroscopy to attain both spatial and spectral information from an object. Vibrational spectroscopic methods, such as Near Infrared (NIR) and Raman spectroscopy, combined with imaging are particularly useful for analysis of biological/pharmaceutical forms. The rapid, non-destructive and non-invasive features of CI mark its potential suitability as a process analytical tool for the pharmaceutical industry, for both process monitoring and quality control in the many stages of drug production. This paper provides an overview of CI principles, instrumentation and analysis. Recent applications of Raman and NIR-CI to pharmaceutical …

Real-Time Plasma Controlled Chemistry In A Two-Frequency, Confined Plasma Etcher, Vladimir Milosavljevic, Albert R. Ellingboe, Cezar Gaman, John V. Ringwood

Articles

The physics issues of developing model-based control of plasma etching are presented. A novel methodology for incorporating real-time model-based control of plasma processing systems is developed. The methodology is developed for control of two dependent variables (ion flux and chemical densities) by two independent controls (27 MHz power and O2flow). A phenomenological physics model of the nonlinear coupling between the independent controls and the dependent variables of the plasma is presented. By using a design of experiment, the functional dependencies of the response surface are determined. In conjunction with the physical model, the dependencies are used to deconvolve the sensor …

Nonequilibrium And Effect Of Gas Mixtures In An Atmospheric Microplasma, Davide Mariotti

Articles

The gas and effective electron temperatures have been estimated for atmospheric microplasma by means of optical emission spectroscopy. The results have shown that the microplasma exhibits nonequilibrium and, as its size is reduced, the two temperatures depart from each other, enhancing the nonequilibrium characteristic. The effect of methane and oxygen concentrations has also been studied, showing that gas mixtures have an important effect on the microplasma state.

Resolving Conflict In Non-Ideal, Complex Systems: Solutions For The Law-Science Breakdown In Environmental And Natural Resource Law, Barbara Cosens

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In 2006, the U.S. Supreme Court decided a consolidated case concerning the scope of the U.S. Army Corps of Engineers' jurisdiction to require permits for dredge and fill of wetlands under section 404 of the Clean Water Act, issuing a plurality, two concurrences, and two dissents. Each opinion has a solid legal foundation, yet none truly makes sense if the science of the resource in question is considered. The opinions in Rapanos v. United States illuminate the struggle at the law-science interface. The problem is not due to either a failure in legal reasoning or a failure in scientific methodology …

Cyberspace Or Face-To-Face: The Teachable Moment And Changing Reference Mediums., Christina M. Desai, Stephanie J. Graves

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This article considers the teaching role of reference librarians by studying the teachable moment in reference transactions, and users’ response to that instruction. An empirical study of instruction was conducted in both virtual and traditional reference milieus, examining the following three services: IM (Instant Messaging), chat, and face-to-face reference. The authors used the same criteria in separate studies of all three services to determine if librarians provided analogous levels of instruction and what factors influenced the likelihood of instruction. Methodology employed included transcript analysis, observation, and patron surveys. Findings indicated that patrons wanted instruction in their reference transactions, regardless of …

Teaching Ip From An Entrepreneurial Counseling And Transactional Perspective, Sean M. O'Connor

Articles

The traditional law school appellate case method is not well-suited to teaching students either the substance and process of counseling entrepreneurial clients or helping such clients create IP strategies that effectively advance their business vision. This Article describes the author’s creation of new courses and clinics to advance teaching IP in the emerging field of entrepreneurship and innovation law

What Do We Talk About When We Talk About Mass Torts?, Anthony J. Sebok

Articles

The article examines the challenges posed by mass torts, particularly the impact of temporal dispersal and latency of injuries, which create significant uncertainties in settlement values. Nagareda critiques the traditional approaches to mass torts—focusing on procedure, substance, and ethics—and proposes a shift toward an administrative framework. He argues that leveraging the self-interest of plaintiffs' lawyers through a fee redistribution mechanism could address settlement dysfunctions, particularly the disparity between present and future claimants. However, the article questions whether this proposal adequately addresses the broader issues in mass tort litigation, especially in immature torts.

Treg Depletion Inhibits Efficacy Of Cancer Immunotherapy: Implications For Clinical Trials., James Curtin, Marianela Candolfi, Tamer Fakhouri, Chunyan Liu, Anderson Alden, Matthew Edwards, Pedro Lowenstein, Maria Castro

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BACKGROUND: Regulatory T lymphocytes (Treg) infiltrate human glioblastoma (GBM); are involved in tumor progression and correlate with tumor grade. Transient elimination of Tregs using CD25 depleting antibodies (PC61) has been found to mediate GBM regression in preclinical models of brain tumors. Clinical trials that combine Treg depletion with tumor vaccination are underway to determine whether transient Treg depletion can enhance anti-tumor immune responses and improve long term survival in cancer patients. FINDINGS: Using a syngeneic intracrabial glioblastoma (GBM) mouse model we show that systemic depletion of Tregs 15 days after tumor implantation using PC61 resulted in a decrease in Tregs …

Motorists Will Have To Pay For The Cost Of Congestion, Thomas Power

Articles

The available road space (the scarce resource) is currently allocated by one’s willingness to sit in traffic jams. The costs incurred in sitting in traffic jams benefits no one – it is pure deadweight loss. The solution is to get the motorist to pay the social cost (marginal congestion cost). By pricing the cost of this traffic congestion in euro, this money could be collected and put to good use, perhaps on improving public transport.

Design Of A Multiple Component Geometric Breast Phantom, Karl G. Baum, Kevin Mcnamara, María Helguera

Articles

The quality and realism of simulated images is currently limited by the quality of the digital phantoms used for the simulations. The transition from simple raster based phantoms to more detailed geometric (mesh) based phantoms has the potential to increase the usefulness of the simulated data. A preliminary breast phantom which contains 12 distinct tissue classes along with the tissue properties necessary for the simulation of dynamic positron emission tomography scans was created (activity and attenuation). The phantom contains multiple components which can be separately manipulated, utilizing geometric transformations, to represent populations or a single individual being imaged in multiple …

Turning The Gene Tap Off; Implications Of Regulating Gene Expression For Cancer Therapeutics, James Curtin, Marianela Candolfi, Weidong Xiong, Pedro Lowenstein, Maria Castro

Articles

Cancer poses a tremendous therapeutic challenge worldwide, highlighting the critical need for developing novel therapeutics. A promising cancer treatment modality is gene therapy, which is a form of molecular medicine designed to introduce into target cells genetic material with therapeutic intent. Anticancer gene therapy strategies currently used in preclinical models, and in some cases in the clinic, include proapoptotic genes, oncolytic/replicative vectors, conditional cytotoxic approaches, inhibition of angiogenesis, inhibition of growth factor signaling, inactivation of oncogenes, inhibition of tumor invasion and stimulation of the immune system. The translation of these novel therapeutic modalities from the preclinical setting to the clinic …

A Visual Indication Of Environmental Humidity Using A Colour Changing Hologram Recorded In A Self-Developing Photopolymer, Izabela Naydenova, Raghavendra Jallapuram, Vincent Toal, Suzanne Martin

Articles

A reflection hologram for visual indication of environmental humidity has been studied. The hologram is recorded in a self-developing photopolymer and changes colour when exposed to a change in humidity and is fully reversible. The range of colour change, reversibility and the response time of the hologram have been studied in a controlled humidity environment. Fully reversible holograms with response times from few seconds to tens of minutes have been designed. Extremely sensitive bright visual humidity indicators, capable of dramatic colour change within a few seconds of breathing on them are demonstrated.

Review And Analysis Of An Energy Efficiency Incentive Program For Commercial Buildings, James A. Mathias, Justin M. Harrell, Marian Tetzlaff

Articles

A program with 13 participants provided reimbursement for improvements to decrease energy use largely in commercial and not-for-profit buildings but also in two government buildings. Electricity and natural gas savings were determined by modeling the energy use by accounting for changes in weather for the 12 months previous to the improvements, and then predicting energy use for the 12 months immediately after the improvements using the same model.

The threshold for verifiable energy savings resulting from building improvements was a maximum uncertainty of 50% at the 68% confidence level. Improvements involving original furnace or air conditioner replacement resulted in significant …

Throttle Icing: Understanding The Icing Mechanism And Effects Of Various Throttle Features, Julie M. Galante-Fox, Donald E. Jarvis, Robert D. Garrick

Articles

Some Electronic Throttle Control (ETC) Air Control Valves (ACV) on automotive internal combustion engines are susceptible to icing of the throttle valve. Ice formation can result in an increase in torque required to open or close the valve. Laboratory studies were conducted to improve the understanding of throttle valve icing on electronic throttle control valves with both aluminum and composite (plastic) bodies over various bore sizes (4 cylinder to 8 cylinder engines). Study results indicated that ice compression at the bore and valve gap, not ice adhesion, is the major contributor to the ETC-ACV icing phenomenon. In addition, testing of …

Nanotechnology In Education: Top-Down And Bottom-Up Approach, Davide Mariotti, Micheal Jackson, Elaine Lewis

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Innovative ideas and approaches for integrating nanotechnology in education are introduced and discussed. Global information and ease of access to scientific information has been considered, as one ofthe factors that may be affecting the way nanotechnology should be introduced in scholarly curricula. Two grand designs have been identified: the first relies on the redistribution of nanotechnology concepts among the existing courses/disciplines and the second promotes nanotechnology as a stand-alone discipline. Overall, it is discussed that whatever curriculum design is chosen, education of high-tech subjects has to combine a top-down with a bottom-up approach. The first serves to convey industry needs …

Mechanism Analysis Using Implicit Constraints, George Sutherland

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This paper introduces an approach to kinematic and dynamic mechanisms analysis where one or more joints are modeled using joint component relative displacements that approximate real joint behavior. This approach allows for the simultaneous nonrecursive solution for both mechanism kinematic parameters and selected dynamic joint reaction forces. Also, for closed loop mechanisms, the approach eliminates the need for forming explicit loop closure constraint equations, so that the dynamic equations of motion (derived using either the Newtonian or Lagrangian method) have a simplified unconstrained form. The key element underlying the approach is the formation of axioms (for the standard mechanism joint …

Lattices In Finite Real Reflection Groups, Colum Watt, Thomas Brady

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For a finite real reflection group, $W$, with Coxeter element $\gamma$ we give a uniform proof that the closed interval, $[I, \gamma]$ forms a lattice in the partial order on $W$ induced by reflection length. The proof involves the construction of a simplicial complex which can be embedded in the type W simplicial generalised associahedron.

Eu's Military Ambitions Clear: Lisbon Treaty Analysis, Tom Clonan

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Many of those who oppose the Lisbon Treaty cite its European Security and Defence Policy (ESDP) and Common Security and Foreign Policy (CSFP) provisions as cause for concern in terms of how they might impact on Irish neutrality or serve to create a pan-European army to rival NATO. Those clauses of the Lisbon Treaty which address security and defence issues are worthy of debate, and may cause concern in some quarters. They do not however impact directly on Irish neutrality. Nor do they amount to a charter for the creation of a standing European army. Much of what the Lisbon …

Russia Fires Shot Across Bows Of Eu, Us And Nato, Tom Clonan

Articles

As both houses of the Russian parliament call upon President Medvedev to support Abkhazia and South Ossetia’s right to self determination, Russian military commanders would appear to be consolidating a so-called ‘buffer zone’ within Georgia proper. According to Moscow, a battalion of 272 Russian troops will occupy eight ‘forward’ positions up to 15km within Georgia proper along its borders with Abkhazia and South Ossetia. A further 250 Russian troops are set to be deployed to the rear of these positions to perform ‘logistics, engineering and support’ functions. As Russia consolidates its foothold in Georgia, serious questions arise as to the …

Influence Of Fiber Manufacturing Tolerances On The Spectral Response Of A Bend Loss Based All-Fiber Edge Filter, Pengfei Wang, Gerald Farrell, Yuliya Semenova, Ginu Rajan

Articles

It is shown that manufacturing tolerances of the fiber parameters bend radius and NA significantly influence the fiber bend loss performance and spectral response of a fiber-based edge filter. A theoretical model, validated by experimental results, is used to determine the changes in key spectral parameters for an edge filter, resulting from changes within their manufacturing tolerance range, for both the bend radius and NA. Finally is shown that bend-radius tuning during fabrication of such filters is a means of mitigating the effect of manufacturing variations.

Group Velocity Dispersion Reduction In Fibre-Based Slow-Light Systems Via Stimulated Brillouin Scattering, Ronny Henker, A. Wiatrek, K. U. Lauterbach, Max Ammann, Andreas Schwarzbacher, Thomas Schneider

Articles

Presented are theoretical investigations and simulations of a reduction of the group velocity dispersion (GVD) in slow-light systems by an optimisation of the gain spectrum of the stimulated Brillouin scattering (SBS). A comparison between a natural Brillouin gain spectrum and a broadened Brillouin gain spectrum with and without two additional losses at its wings is demonstrated. The focus of the theoretical examination was set on the superposition of a gain and two losses with an equal magnitude. Therefore, a low GVD and a high group index change could be achieved and hence, a small pulse distortion and a high time …

In Silico Comparison Of Transcript Abundances During Arabidopsis Thaliana And Glycine Max Resistance To Fusarium Virguliforme, Jiazheng Yuan, Mengxia Zhu, David A. Lightfoot, M Javed Iqbal, Jack Y. Yang, Khalid Meksem

Articles

Background
Sudden death syndrome (SDS) of soybean (Glycine max L. Merr.) is an economically important disease, caused by the semi-biotrophic fungus Fusarium solani f. sp. glycines, recently renamed Fusarium virguliforme (Fv). Due to the complexity and length of the soybean-Fusarium interaction, the molecular mechanisms underlying plant resistance and susceptibility to the pathogen are not fully understood. F. virguliforme has a very wide host range for the ability to cause root rot and a very narrow host range for the ability to cause a leaf scorch. Arabidopsis thaliana is a host for many types of phytopathogens including bacteria, fungi, viruses and …

Extended Nonnegative Tensor Factorisation Models For Musical Sound Source Separation, Derry Fitzgerald, Matt Cranitch, Eugene Coyle

Articles

Recently, shift-invariant tensor factorisation algorithms have been proposed for the purposes of sound souce separation of pitched musical instruments. However, in practice, existing alogorithsm require the use of log-frequency spectrograms to allow shift invariance in frequency which causes problems when attempting to resynthesise the separated sources. Further, it is difficult to impose harmonicity constraints on the recovered basis functions. This paper proposes a new additive synthesis-based approach which allows the use of linear-frequency spectrograms as well as imposing strict harmonic constraints, resulting in an improved model. Futher, these additional constraints allow the addition of a source filter model to the …

Technology-Aided Participative Methods In Environmental Assessment: An International Perspective, Ainhoa Gonzalez, Alan Gilmer, Ronan Foley, John Sweeney, John Fry

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Provisions for citizen involvement in the assessment of potential environmental effects of certain plans, programmes and projects are present in current legislation. An international survey revealed that public participation is common practice in European and some other countries worldwide. However, a number of issues are observed to affect public involvement in EIA/SEA processes and expert opinion differs when evaluating the effectiveness of existing participative methods. Results suggest that technology-aided methods can improve traditional participation processes. In particular, GIS has the potential to increase community knowledge and enhance involvement by communicating information more effectively. Variable accessibility to technology and data quality …

Career Choices And Career Advancement: Chinese American Librarians In The 21st Century, Ruan Lian, Jian Anna Xiong

Articles

There is an increasing need to understand Chinese American librarians as one of the largest ethnic librarian groups in American library communities and a renewed interest to demonstrate a critical role they play in the Library and Information Science profession. This paper documents some strategies Chinese American librarians have adopted to meet the challenges and barriers they face. It is hoped that this study will encourage Chinese American librarians to develop methods for analyzing their careers so as to reach higher career goals.

Bankruptcy's Undiscovered Country, Douglas G. Baird

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No abstract provided.

A Reader's Companion To Against Prediction: A Reply To Ariela Gross, Yoram Margalioth, And Yoav Sapir On Economic Modeling, Selective Incapacitation, Governmentality, And Race, Bernard E. Harcourt

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From parole prediction instruments and violent sexual predator scores to racial profiling on the highways, instruments to predict future dangerousness, drug-courier profiles, and IRS computer algorithms to detect tax evaders, the rise of actuarial methods in the field of crime and punishment presents a number of challenging issues at the intersection of economic theory, sociology, history, race studies, criminology, social theory, and law. The three review articles of Against Prediction: Profiling, Policing, and Punishing in an Actuarial Age by Ariela Gross, Yoram Margalioth, and Yoav Sapir, raise these challenges in their very best light. Ranging from the heights of poststructuralist …

Originalism's Expiration Date, Adam M. Samaha

Articles

The Constitution of the United States declares itself supreme law, but even the amended document is ancient. By 2008, the predicted age of a randomly selected word in this text reached 178 years. The judiciary, for its part, might not interpret the text until decades after ratification. For Article V amendments, the average lag between ratification and Supreme Court interpretation has been about 40 years. The question is how these features of our supreme law might influence the choice of interpretive method and, ultimately, constitutional decision-making. In particular, some scholars indicate that originalism may be a strong force in adjudication …

Competition And Privacy In Web 2.0 And The Cloud, Randal C. Picker

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No abstract provided.

Privacy Versus Antidiscrimination, Lior Strahilevitz

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No abstract provided.