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Using Drawings To Understand Perceptions Of Civic Engagement Across Disciplines: ‘Seeing Is Understanding’, Sharon Feeney, John Hogan
Using Drawings To Understand Perceptions Of Civic Engagement Across Disciplines: ‘Seeing Is Understanding’, Sharon Feeney, John Hogan
Articles
In this article, we wish to investigate if disciplinary differences exist among students when considering the topic of civic engagement. We use freehand drawing to create a learning environment in the classroom wherein students can seek to develop meaningful associations with civic engagement. The drawings examined here, produced by three different class groups, provide insights into how young adults perceive their society and their place in it, and thus communicate their understanding of civic engagement. Freehand drawing, in bypassing cognitive verbal processing routes, leads students to produce clearer and more holistic images. It allows them to put into visuals a …
From Dreaming To Believing: A Review Of Consumer Engagement Behaviours With Brands’ Social Media Content Across The Holiday Travel Process, Dean Creevey, Etain Kidney, Glenn Mehta
From Dreaming To Believing: A Review Of Consumer Engagement Behaviours With Brands’ Social Media Content Across The Holiday Travel Process, Dean Creevey, Etain Kidney, Glenn Mehta
Articles
This paper reviews social media user engagement behaviours with brands and proposes a new stage within the travel process. Specifically, the pre-trip stage is examined and investigation into a two sub-stage split is proposed; pre-purchase and post-purchase. Dubbed the Believing phase, this paper calls for research into the patterns of engagement behaviour towards hotel brands’ content at this currently under-researched stage. Current social media-focussed research examines influence on purchasing decisions of users, social media usage on-site, and post-trip evaluation. There remains a conceptual gap highlighting the behavioural patterns of users during the period between initial purchase and subsequent departure.
The Effect Of Atmospheric Cold Plasma On Bacterial Stress Responses And Virulence Using Listeria Monocytogenes Knockout Mutants, Apurva Patange, Conor O'Byrne, Daniela Boehm, Patrick J. Cullen, Kevin Keener, Paula Bourke
The Effect Of Atmospheric Cold Plasma On Bacterial Stress Responses And Virulence Using Listeria Monocytogenes Knockout Mutants, Apurva Patange, Conor O'Byrne, Daniela Boehm, Patrick J. Cullen, Kevin Keener, Paula Bourke
Articles
Listeria monocytogenes is an opportunistic intracellular pathogen commonly associated with serious 16 infections and multiple food-borne outbreaks. In this study, we investigated the influence of 17 atmospheric cold plasma (80 kV, 50 Hz) on L. monocytogenes (EGD-e) and its knockout mutants of 18 sigB, rsbR, prfA, gadD and lmo0799 genes at different treatment time intervals. Further, to ascertain if 19 sub-lethal environmental stress conditions could influence L. monocytogenes survival and growth 20 responses, atmospheric cold plasma (ACP) resistance was evaluated for the cultures exposed to cold 21 (4°C) or acid (pH 4) stress for 1 h. The results demonstrate that …
Direct Analysis Of Calcium In Liquid Infant Formula Via Laser-Induced Breakdown Spectroscopy (Libs), Xavier Cama-Moncunill, Maria Markiewicz-Keszycka, Patrick J. Cullen, Carl Sullivan, Maria Piedad Casado-Gavalda
Direct Analysis Of Calcium In Liquid Infant Formula Via Laser-Induced Breakdown Spectroscopy (Libs), Xavier Cama-Moncunill, Maria Markiewicz-Keszycka, Patrick J. Cullen, Carl Sullivan, Maria Piedad Casado-Gavalda
Articles
The present work illustrates the potential of laser-induced breakdown spectroscopy (LIBS) for the direct analysis of liquid food products. The aim of the experiment was to predict calcium content in ready-to-feed infant formula. The analysis was performed by a LIBS system coupled to a liquid sample chamber with a rotatory wheel that presents the liquid to the laser beam as a thin film. Multivariate analysis with partial least squares regression (PLSR) was performed to correlate LIBS spectral data to reference calcium contents. The obtained PLSR model exhibited a good fit and linearity, as indicated by the coefficients of determination for …
Targeting Lipoprotein Biogenesis: Considerations Towards Antimicrobials, Toufic El Arnaout, Tewfic Soulimane
Targeting Lipoprotein Biogenesis: Considerations Towards Antimicrobials, Toufic El Arnaout, Tewfic Soulimane
Articles
Decades have passed without approval of a new antibiotic class. Several companies have recently halted related discovery efforts because of multiple obstacles. One promising route under research is to target the lipoprotein maturation pathway in light of major recent findings and the virulence roles of lipoproteins. To support the future design of selective drugs, considerations and priority-setting are established for the main lipoprotein processing enzymes (Lgt, LspA, and Lnt) based on microbiology, biochemistry, structural biology, chemical design, and pharmacology. Although not all bacterial species will be similarly impacted by drug candidates, several advantages make LspA a top target to pursue …
Investigation Of Mechanisms Involved In Germination Enhancement Of Wheat (Triticum Aestivum) By Cold Plasma: Effects On Seed Surface Chemistry And Characteristics, Agata Los, Dana Ziuzina, Daniela Boehm, Patrick J. Cullen, Paula Bourke
Investigation Of Mechanisms Involved In Germination Enhancement Of Wheat (Triticum Aestivum) By Cold Plasma: Effects On Seed Surface Chemistry And Characteristics, Agata Los, Dana Ziuzina, Daniela Boehm, Patrick J. Cullen, Paula Bourke
Articles
Recent reports indicate that atmospheric cold plasma (ACP) treatment of seeds can enhance their germination, however, the mechanisms of action are not yet entirely clear. In the present work, we report on the effects of plasma treatment on wheat seed germination and seedling growth. Additionally, changes in the surface chemistry and characteristics of the wheat seeds exposed to plasma were investigated. Treatments of 30–60 s significantly enhanced the germination rate and showed positive effects on seedling growth. ACP resulted in changes of seed surface and chemical characteristics including water uptake and contact angle values. Changes in seed pH and total …
Thermostable Phytase In Feed And Fuel Industries, Ushasree Mrudula Vasudevan, Amit Jaiswal, Shyam Krishna, Ashok Pandey
Thermostable Phytase In Feed And Fuel Industries, Ushasree Mrudula Vasudevan, Amit Jaiswal, Shyam Krishna, Ashok Pandey
Articles
Phytase with wide ranging biochemical properties has long been utilized in a multitude of industries, even so, thermostability plays a crucial factor in choosing the right phytase in a few of the sectors. Mesophilic phytases are not considered to be a viable option in the feed industry owing to its limited stability in the required feed processing temperature. In the recent past, inclusion of thermostable phytase in fuel ethanol production from starch based raw material has been demonstrated with economic benefits. Therefore, considerable emphasis has been placed on using complementary approaches such as mining of extremophilic microbial wealth, encapsulation and …
Nanostructured Materials For Food Applications: Spectroscopy, Microscopy And Physical Properties, Shubham Sharma, Swana Jaiswal, Brendan Duffy, Amit Jaiswal
Nanostructured Materials For Food Applications: Spectroscopy, Microscopy And Physical Properties, Shubham Sharma, Swana Jaiswal, Brendan Duffy, Amit Jaiswal
Articles
Nanotechnology deals with the matter of atomic or molecular scale. Other factors that define the character of a nanoparticle are its physical and chemical properties, such as surface area, surface charge, hydrophobicity of the surface, the thermal stability of the nanoparticle, and its antimicrobial activity. A nanoparticle is usually characterized by using microscopic and spectroscopic techniques. Microscopic techniques are used to characterize the size, shape, and location of the nanoparticle by producing an image of the individual nanoparticle. Several techniques, such as scanning electron microscopy (SEM), transmission electron microscopy/high resolution transmission electron microscopy (TEM/HRTEM), atomic force microscopy (AFM) and scanning …
Improving Enzymatic Hydrolysis Of Brewer Spent Grain With Nonthermal Plasma, Rajeev Ravindran, Chaitanya Sarangapani, Swarna Jaiswal, Peng Lu, Patrick J. Cullen, Paula Bourke, Amit Jaiswal
Improving Enzymatic Hydrolysis Of Brewer Spent Grain With Nonthermal Plasma, Rajeev Ravindran, Chaitanya Sarangapani, Swarna Jaiswal, Peng Lu, Patrick J. Cullen, Paula Bourke, Amit Jaiswal
Articles
In this study, a new pre-treatment method based on novel non-thermal plasma technology was developed to improve the enzymatic hydrolysis of brewer’s spent grain (BSG) and subsequent bioethanol production. A submerged dielectric barrier discharge plasma reactor system was applied for this purpose. Pre-treatments were performed by taking into account variables including; voltages (22 kV, 25 kV and 28 kV), solvent (acid, alkali and water) and time (5, 10, 15 min). The resulting treated biomass was subjected to enzymatic hydrolysis. A 2.14-fold increase in yield of the reducing sugar was achieved post hydrolysis when the biomass was treated in water for …
Exploring How Age Influences Sensory Perception, Thirst And Hunger During The Consumption Of Oral Nutritional Supplements Using The Check-All-That-Apply Methodology, Emma Regan, Graham O'Neill, Scott C. Hutchings, Dolores O'Riordan
Exploring How Age Influences Sensory Perception, Thirst And Hunger During The Consumption Of Oral Nutritional Supplements Using The Check-All-That-Apply Methodology, Emma Regan, Graham O'Neill, Scott C. Hutchings, Dolores O'Riordan
Articles
The Check-all-that-apply (CATA) method has been widely used for the sensory characterisation of many different foods and beverages. However, this methodology has been rarely used with older adults. The aim of this study was to measure the effectiveness of the CATA methodology to investigate the differences in sensory perception of Oral Nutritional Supplements (ONS) between younger and community dwelling older adults over successive sips of a full volume of two ONS. The study also sought to measure the effects of ONS on thirst, hunger and fullness. 160 participants (eighty aged over 65 and eighty aged 18-35) evaluated two ONS over …
Compact Broadband Triple-Ring Five-Port Reflectometer For Microwave Brain Imaging Applications, Toufiq Md Hossain, Mohd Faizal Jamlos, Mohd Aminudin Jamlos, Ping Jack Shoh, Siti Zuraidah Ibrahim, Muammar Mohamad Isa, Dominque M.M.-P. Schreurs, Adam Narbudowicz, Mohd Fairusham Ghazali
Compact Broadband Triple-Ring Five-Port Reflectometer For Microwave Brain Imaging Applications, Toufiq Md Hossain, Mohd Faizal Jamlos, Mohd Aminudin Jamlos, Ping Jack Shoh, Siti Zuraidah Ibrahim, Muammar Mohamad Isa, Dominque M.M.-P. Schreurs, Adam Narbudowicz, Mohd Fairusham Ghazali
Articles
The broadband five-port refectometer (FPR) is proposed using a triple-ring based technique. The design introduces a tapering in the inter-ring transmission lines (TLs), which provides additional degrees of freedom for optimization and contributes to increased bandwidth. The miniaturization strategy allows incorporating the third ring without signifcant size increase. In addition, a method for expressing the effective physical dimension of a planar symmetric FPR is also presented in an easily comprehensible way, which can be implemented for other symmetric planar junctions with more than four ports. The proposed design comprises three concentric rings with phase-shifting arrangements between the inter-ring TLs and …
Craft Beer And The Rising Tide Effect: An Empirical Study Of Sharing And Collaboration Among Seattle’S Craft Breweries, Zahr K. Said
Craft Beer And The Rising Tide Effect: An Empirical Study Of Sharing And Collaboration Among Seattle’S Craft Breweries, Zahr K. Said
Articles
This qualitative empirical research project studies Seattle’s craft brewing industry as a thriving entrepreneurial ecosystem that displays widespread collaboration and innovation. Drawing on data collected in 22 face-to-face formal interviews conducted with industry participants, the Article explores the community’s attitudes, practices, and norms with respect to collaboration and intellectual property (IP). It joins a growing body of qualitative empirical IP scholarship that maps misalignments between law and practice “on the ground,” seeking to offer a more accurate and pluralistic account of an innovative industry. The craft brewing community in Seattle cooperates extensively while continuing to compete actively for consumers. In …
Persistence Pays Off: Paying Attention To What The Lstm Gating Mechanism Persists, John D. Kelleher, Giancarlo Salton
Persistence Pays Off: Paying Attention To What The Lstm Gating Mechanism Persists, John D. Kelleher, Giancarlo Salton
Articles
Language Models (LMs) are important components in several Natural Language Processing systems. Recurrent Neural Network LMs composed of LSTM units, especially those augmented with an external memory, have achieved state-of-the-art results. However, these models still struggle to process long sequences which are more likely to contain long-distance dependencies because of information fading and a bias towards more recent information. In this paper we demonstrate an effective mechanism for retrieving information in a memory augmented LSTM LM based on attending to information in memory in proportion to the number of timesteps the LSTM gating mechanism persisted the information.
Double Deadbeat Plus Repetitive Control Scheme For Microgrid System, Sreedhar Madichetty, Malabika Basu, Sukumar Mishra, Josep M. Guerrero
Double Deadbeat Plus Repetitive Control Scheme For Microgrid System, Sreedhar Madichetty, Malabika Basu, Sukumar Mishra, Josep M. Guerrero
Articles
Parallel connection of converters is a convenient choice when system capacity is to be increased. Parallel-connected voltage source converters, especially neutral point clamped converters, are one of the best choices for its range. However, with the parallel connectivity, the converter possesses a circulating current in its legs, which consequently threatens the safe operation of the system. To alleviate this circulating current problem, in this paper, a double deadbeat (DD) plus repetitive control (RC) scheme is proposed. The RC scheme is employed to mitigate the circulating currents and the DD loop control scheme is employed to achieve a high operating bandwidth …
Developing Gold Nanoparticles-Conjugated Aflatoxin B1 Antifungal Strips, Tobiloba Sojinrin, Kangze Liu, Kan Wang, Daxiang Cui, Hugh Byrne, James Curtin, Furong Tian
Developing Gold Nanoparticles-Conjugated Aflatoxin B1 Antifungal Strips, Tobiloba Sojinrin, Kangze Liu, Kan Wang, Daxiang Cui, Hugh Byrne, James Curtin, Furong Tian
Articles
Lateral flow immunochromatographic assays are a powerful diagnostic tool for point-of-care tests, based on their simplicity, specificity, and sensitivity. In this study, a rapid and sensitive gold nanoparticle (AuNP) immunochromatographic strip is produced for detecting aflatoxin B1 (AFB1) in suspicious fungi-contaminated food samples. The 10 nm AuNPs were encompassed by bovine serum albumin (BSA) and AFB1 antibody. Thin-layer chromatography, gel electrophoresis and nuclear magnetic resonance spectroscopy were employed for analysing the chemical complexes. Various concentrations of AFB1 antigen (0–16 ng/mL) were tested with AFB1 antibody–BSA–AuNPs (conjugated AuNPs) and then analysed by scanning electron microscopy, ultraviolet–visible spectroscopy, and Zetasizer. The results …
Bigger Versus Similar: Selecting A Background Corpus For First Story Detection Based On Distributional Similarity, Fei Wang, Robert J. Ross, John D. Kelleher
Bigger Versus Similar: Selecting A Background Corpus For First Story Detection Based On Distributional Similarity, Fei Wang, Robert J. Ross, John D. Kelleher
Articles
The current state of the art for First Story Detection (FSD) are nearest neighbourbased models with traditional term vector representations; however, one challenge faced by FSD models is that the document representation is usually defined by the vocabulary and term frequency from a background corpus. Consequently, the ideal background corpus should arguably be both large-scale to ensure adequate term coverage, and similar to the target domain in terms of the language distribution. However, given these two factors cannot always be mutually satisfied, in this paper we examine whether the distributional similarity of common terms is more important than the scale …
Large-Scale Green Supplier Selection Approach Under A Q-Rung Interval-Valued Orthopair Fuzzy Environment, Limei Liu, Wenzhi Cao, Biao Shi, Ming Tang
Large-Scale Green Supplier Selection Approach Under A Q-Rung Interval-Valued Orthopair Fuzzy Environment, Limei Liu, Wenzhi Cao, Biao Shi, Ming Tang
Articles
As enterprises pay more and more attention to environmental issues, the green supply chain management (GSCM) mode has been extensively utilized to guarantee profit and sustainable development. Greensupplierselection(GSS),whichisakeysegmentofGSCM,hasbeeninvestigated to put forward plenty of GSS approaches.
The "Invisible Hand" Of Peer Review: The Implications Of Author-Referee Networks On Peer Review In A Scholarly Journal, Pierpaolo Dondio, Niccolo Casnici, Nigel Gilbert, Francisco Grimaldo, Flaminio Squazzoni
The "Invisible Hand" Of Peer Review: The Implications Of Author-Referee Networks On Peer Review In A Scholarly Journal, Pierpaolo Dondio, Niccolo Casnici, Nigel Gilbert, Francisco Grimaldo, Flaminio Squazzoni
Articles
Peer review is not only a quality screening mechanism for scholarly journals. It also connects authors and referees either directly or indirectly. This means that their positions in the network structure of the community could influence the process, while peer review could in turn influence subsequent networking and collaboration. This paper aims to map these complex network implications by looking at 2232 author/referee couples in an interdisciplinary journal that uses double blind peer review. By reconstructing temporal co-authorship networks, we found that referees tended to recommend more positively submissions by authors who were within three steps in their collaboration network. …
Languages For Different Health Information Readers: Multitrait-Multimethod Content Analysis Of Cochrane Systematic Reviews Textual Summary Formats, Jasna Karačić, Pierpaolo Dondio, Ivan Buljan, Darko Hren, Ana Marušić
Languages For Different Health Information Readers: Multitrait-Multimethod Content Analysis Of Cochrane Systematic Reviews Textual Summary Formats, Jasna Karačić, Pierpaolo Dondio, Ivan Buljan, Darko Hren, Ana Marušić
Articles
Background: Although subjective expressions and linguistic fluency have been shown as important factors in processing and interpreting textual facts, analyses of these traits in textual health information for different audiences are lacking. We analyzed the readability and linguistic psychological and emotional characteristics of different textual summary formats of Cochrane systematic reviews. Methods: We performed a multitrait-multimethod cross-sectional study of Press releases available at Cochrane web site (n= 162) and corresponding Scientific abstracts (n= 158), Cochrane Clinical Answers (n= 35) and Plain language summaries in English (n= 156), French (n= 101), German (n= 41) and Croatian (n=156). We used SMOG index …
Cs1: How Will They Do? How Can We Help? A Decade Of Research And Practice, Keith Quille, Susan Bergin
Cs1: How Will They Do? How Can We Help? A Decade Of Research And Practice, Keith Quille, Susan Bergin
Articles
Background and Context: Computer Science attrition rates (in the western world) are very concerning, with a large number of students failing to progress each year. It is well acknowledged that a significant factor of this attrition, is the students’ difficulty to master the introductory programming module, often referred to as CS1.
Objective: The objective of this article is to describe the evolution of a prediction model named PreSS (Predict Student Success) over a 13-year period (2005–2018).
Method: This article ties together, the PreSS prediction model; pilot studies; a longitudinal, multi-institutional re-validation and replication …
Getting Past The Imperial Presidency, Deborah Pearlstein
Getting Past The Imperial Presidency, Deborah Pearlstein
Articles
In an age in which the “imperial presidency” seems to have reached its apex, perhaps most alarmingly surrounding the use of military force, conventional wisdom remains fixed that constitutional and international law play a negligible role in constraining executive branch decision-making in this realm. Yet as this Article explains, the factual case that supports the conventional view, based largely on highly selected incidents of presidential behavior, is meaningless in any standard empirical sense. Indeed, the canonical listing of presidential decisions to use force without prior authorization feeds a compliance-centered focus on the study of legal constraint rooted in long-since abandoned …
Abolish Ice . . . And Then What?, Peter L. Markowitz
Abolish Ice . . . And Then What?, Peter L. Markowitz
Articles
In recent years, activists and then politicians began calling for the abolition of the United States’s interior immigration-enforcement agency: U.S. Immigration and Customs Enforcement (ICE). Many people have misinterpreted the call to “Abolish ICE” as merely a spontaneous rhetorical device used to express outrage at the current Administration’s brutal immigration policies. In fact, abolishing ICE is the natural extension of years of thoughtful organizing by a loose coalition of grassroots immigrant-rights groups. These organizations are serious, not only about their literal goal to eliminate the agency, but also about not replacing it with another dedicated agency of immigration police. Accordingly, …
Commercial Speech Protection As Consumer Protection, Felix T. Wu
Commercial Speech Protection As Consumer Protection, Felix T. Wu
Articles
The Supreme Court has long said that “the extension of First Amendment protection to commercial speech is justified principally by the value to consumers of the information such speech provides.” In other words, consumers—the recipients or listeners of commercial speech—are the ones the doctrine is meant to protect. In previous work, I explored the implications of taking this view seriously in three contexts: compelled speech, speech among commercial entities, and unwanted marketing. In each of those contexts, adopting a listener-oriented approach leads to the conclusion that many forms of commercial speech regulation should receive far less First Amendment scrutiny than …
The Role Of Previous Discourse In Identifying Public Textual Cyberbullying, Aurelia Power, Anthony Keane, Brian Nolan, Brian O'Neill
The Role Of Previous Discourse In Identifying Public Textual Cyberbullying, Aurelia Power, Anthony Keane, Brian Nolan, Brian O'Neill
Articles
In this paper we investigate the contribution of previous discourse in identifying elements that are key to detecting public textual cyberbullying. Based on the analysis of our dataset, we first discuss the missing cyberbullying elements and the grammatical structures representative of discourse-dependent cyberbullying discourse. Then we identify four types of discourse dependent cyberbullying constructions: (1) fully inferable constructions, (2) personal marker and cyberbullying link inferable constructions, (3) dysphemistic element and cyberbullying link inferable constructions, and (4) dysphemistic element inferable constructions. Finally, we formalise a framework to resolve the missing cyberbullying elements that proposes several resolution algorithms. The resolution algorithms target …
Antebellum And Postbellum Testamentary Transfers In Three Kentucky Counties Symposium: Empirical Analysis Of Wealth Transfer Law, Alberto B. Lopez
Antebellum And Postbellum Testamentary Transfers In Three Kentucky Counties Symposium: Empirical Analysis Of Wealth Transfer Law, Alberto B. Lopez
Articles
This Article analyzes wills and inventories probated in three Kentucky counties, Boone, Woodford, and Wayne Counties, between 186 and 187. The results of the study show that married women in the three counties generally did not execute wills during the sample period, which is an expected result given the testamentary limitations imposed upon married women by Kentucky law. Despite dual encumbrances imposed by common and statutory law during the sample period, legislative and judicial action before, during, and after the sampled decade illustrates the advance of women's property rights in Kentucky. The Kentucky General Assembly passed a number of private …
Exploring Subcellular Responses Of Prostate Cancer Cells To X-Ray Exposure By Raman Mapping, Maciej Roman, Agnieszka Panek, Hugh Byrne, Tomasz P Wrobel, Esen Efeoglu, Czeslawa Paluszkiewicz, Wojciech Maria Kwiatek
Exploring Subcellular Responses Of Prostate Cancer Cells To X-Ray Exposure By Raman Mapping, Maciej Roman, Agnieszka Panek, Hugh Byrne, Tomasz P Wrobel, Esen Efeoglu, Czeslawa Paluszkiewicz, Wojciech Maria Kwiatek
Articles
Understanding the response of cancer cells to ionising radiation is a crucial step in modern radiotherapy. Raman microspectroscopy, together with Partial Least Squares Regression (PLSR) analysis has been shown to be a powerful tool for monitoring biochemical changes of irradiated cells on the subcellular level. However, to date, the majority of Raman studies have been performed using a single spectrum per cell, giving a limited view of the total biochemical response of the cell. In the current study, Raman mapping of the whole cell area was undertaken to ensure a more comprehensive understanding of the changes induced by X-ray radiation. …
Graphene Nanoflake Uptake Mediated By Scavenger Receptors, Fatima Alnasser, Valentina Castagnola, Luca Boselli, Margarita Esquivel-Gaon, Esen Efeoglu, Jennifer Mcintyre, Hugh Byrne, Kenneth A. Dawson
Graphene Nanoflake Uptake Mediated By Scavenger Receptors, Fatima Alnasser, Valentina Castagnola, Luca Boselli, Margarita Esquivel-Gaon, Esen Efeoglu, Jennifer Mcintyre, Hugh Byrne, Kenneth A. Dawson
Articles
The biological interactions of graphene have been extensively investigated over the last 10 years. However, very little is known about graphene interactions with the cell surface and how the graphene internalization process is driven and mediated by specific recognition sites at the interface with the cell. In this work, we propose a methodology to investigate direct molecular correlations between the biomolecular corona of graphene and specific cell receptors, showing that key protein recognition motifs, presented on the nanomaterial surface, can engage selectively with specific cell receptors. We consider the case of apolipoprotein A-I, found to be very abundant in the …
Analysis Of Bodily Fluids Using Vibrational Spectroscopy: A Direct Comparison Of Raman Scattering And Infrared Absorption Techniques For The Case Of Glucose In Blood Serum, Drishya Prachalil, Clément Bruno, Franck Bonnier, Helen Blasco, Igor Chourpa, Matthew Baker, Jennifer Mcintyre, Hugh Byrne
Analysis Of Bodily Fluids Using Vibrational Spectroscopy: A Direct Comparison Of Raman Scattering And Infrared Absorption Techniques For The Case Of Glucose In Blood Serum, Drishya Prachalil, Clément Bruno, Franck Bonnier, Helen Blasco, Igor Chourpa, Matthew Baker, Jennifer Mcintyre, Hugh Byrne
Articles
Analysis of biomarkers present in the blood stream can potentially deliver crucial information on patient health and indicate the presence of numerous pathologies. The potential of vibrational spectroscopic analysis of human serum for diagnostic purposes has been widely investigated and, in recent times, infrared absorption spectroscopy, coupled with ultra-filtration and multivariate analysis techniques, has attracted increasing attention, both clinical and commercial. However, such methods commonly employ a drying step, which may hinder the clinical work flow and thus hamper their clinical deployment. As an alternative, this study explores the use of Raman spectroscopy, similarly coupled with ultra-filtration and multivariate analysis …
Improved Performance Of Near Infrared Excitation Raman Spectroscopy Using Reflective Thin-Film Gold On Glass Substrates For Cytology Samples, Sinead Barton, Kevin O'Dwyer, Marion Butler, Hugh Byrne, Luke O'Neill, Bryan M. Hennelly
Improved Performance Of Near Infrared Excitation Raman Spectroscopy Using Reflective Thin-Film Gold On Glass Substrates For Cytology Samples, Sinead Barton, Kevin O'Dwyer, Marion Butler, Hugh Byrne, Luke O'Neill, Bryan M. Hennelly
Articles
Confocal near-infrared Raman spectroscopy has been shown to have applications in the area of clinical biology. A source wavelength in the near infrared is preferred over visible wavelengths for inspecting biological samples due to superior wave number resolution and reduced photo damage. However, these excitation sources have a number of drawbacks when compared to lasers in the visible wavelength region, including the requirement to use expensive highly pure crystal substrates such as Raman grade calcium fluoride as well as long acquisition times due to the lower Raman scattering efficiency. This paper investigates the use of a reflective substrate comprising a …
Numerically Modelling Time And Dose Dependent Cytotoxicity, Hugh Byrne, Marcus A. Maher
Numerically Modelling Time And Dose Dependent Cytotoxicity, Hugh Byrne, Marcus A. Maher
Articles
Dose-response curves are fundamental tools of in vitro toxicology, extensively employed in toxicant or drug screening. They are expressed by a variety of end-points and assays, measured at different time-points in a choice of cell-lines, but are typically quantified only using the mean concentration for 50% response (e.g. drug efficacy or pathway inhibition) as an indicator of overall effect. However, the response is the result of a complex and dynamic cascade of events which occur between the initial exposure and the measured end-point, and the characteristic rates of the contributing stages govern the dose response and ultimately the measured characteristic …