Digital Commons Network^™

Promoting Corporate Irresponsibility? Delaware As The Intellectual Property Holding State, Xuan-Thao Nguyen

Articles

This article is about Delaware corporate irresponsibility. Delaware has stealthily become the center of all things intellectual property. As the leader of onshore tax havens since the early 1980s, Delaware attracts multistate corporations to engage in aggressive tax avoidance schemes. Specifically, Delaware has legislatively and methodically attracted the creation of Intellectual Property Holding Companies (IPHCs), enabling companies to avoid paying their share of taxes to sister states on the income generated from the use of Intellectual Property assets. This article traces the rise of Delaware as the intellectual property state and concludes that the benefits Delaware enjoys promote corporate irresponsibility …

The Automated Administrative State: A Crisis Of Legitimacy, Ryan Calo, Danielle Keats Citron

Articles

The legitimacy of the administrative state is premised on our faith in agency expertise. Despite their extra-constitutional structure, administrative agencies have been on firm footing for a long time in reverence to their critical role in governing a complex, evolving society. They are delegated enormous power because they respond expertly and nimbly to evolving conditions. In recent decades, state and federal agencies have embraced a novel mode of operation: automation. Agencies rely more and more on software and algorithms in carrying out their delegated responsibilities. The automated administrative state, however, is demonstrably riddled with concerns. Legal challenges regarding the denial …

Attitudes Towards Ip Present Among Seattle Craft Breweries, Zahr K. Said

Articles

No abstract provided.

An Ensemble Approach For Annotating Source Code Identifiers With Part-Of-Speech Tags, Christian D. Newman,, Michael J. Decker, Reem S. Alsuhaibani, Anthony Peruma, Mohamed Wiem Mkaouer, Satyajit Mohapatra, Tejal Vishnoi, Marcos Zampieri, Timothy Sheldon, Emily Hill

Articles

This paper presents an ensemble part-of-speech tagging approach for source code identifiers. Ensemble tagging is a technique that uses machine-learning and the output from multiple part-of-speech taggers to annotate natural language text at a higher quality than the part-of-speech taggers are able to obtain independently. Our ensemble uses three state-of-the-art part-of-speech taggers: SWUM, POSSE, and Stanford. We study the quality of the ensemble's annotations on five different types of identifier names: function, class, attribute, parameter, and declaration statement at the level of both individual words and full identifier names. We also study and discuss the weaknesses of our tagger to …

The Energy Transition And Mining: Reconciling The Growth Of Renewable Energy With The Need For New Mineral Development, Alexandra B. Klass, Allison J. Mitchell

Articles

Under the Paris Agreement, the global governmental signatories embraced the goal to hold global average temperature increase to “well below 2°C above pre-industrial levels” while “pursuing efforts to limit the temperature increase to 1.5°C above pre-industrial levels.” Almost every country in the world signed on to the Paris Agreement, adopting the prevailing science that anthropocentric greenhouse gas emissions would result in rising global temperatures and catastrophic damages from climate change in the absence of immediate action. In pursuit of this goal, the signatories agreed that all member countries would work together to bring greenhouse gas emissions to zero within the …

From Protecting Water Quality To Protecting States’ Rights: Fifty Years Of Supreme Court Clean Water Act Statutory Interpretation, Stephen M. Johnson

Articles

In 1972, a bipartisan Congress enacted the Clean Water Act “to restore and maintain the chemical, physical, and biological integrity of the Nation’s waters.” Almost fifty years have passed since Congress enacted the law, and during that time, the Supreme Court has played a significant role in the administration and evolution of the law. Since the dawn of the environmental era in the 1970s, the Supreme Court has heard more cases involving the Clean Water Act than any other environmental law. However, the manner in which the Court has analyzed the law has changed substantially over the last half century. …

A Multi‑Level Review Of Engineering Ethics Education: Towards A Socio‑Technical Orientation Of Engineering Education For Ethics, Diana Adela Martin, Eddie Conlon, Brian Bowe

Articles

This paper aims to review the empirical and theoretical research on engineering ethics education, by focusing on the challenges reported in the literature. The analysis is conducted at four levels of the engineering education system. First, the individual level is dedicated to findings about teaching practices reported by instructors. Second, the institutional level brings together findings about the implementation and presence of ethics within engineering programmes. Third, the level of policy situates findings about engineering ethics education in the context of accreditation. Finally, there is the level of the culture of engineering education. The multi-level analysis allows us to address …

Isolation Intervals Of The Real Roots Of The Parametric Cubic Equation, Emil Prodanov

Articles

The isolation intervals of the real roots of the real symbolic monic cubic polynomial $p(x) = x^3 + a x^2 + b x + c$ are found in terms of simple functions of the coefficients of the polynomial (such as: $-a$, $-a/3$, $-c/b$, $\pm \sqrt{-b}$, when $b$ is negative), and the roots of some auxiliary quadratic equations whose coefficients are also simple functions of the coefficients of the cubic. All possible cases are presented with clear and very detailed diagrams. It is very easy to identify which of these diagrams is the relevant one for any given cubic equation and …

A Step Closer To Elastogenesis On Demand; Inducing Mature Elastic Fibre Deposition In A Natural Biomaterial Scaffold, Francisco R. Almeida-González, Arlyng González-Vázquez, Suzanne M. Mithieux, Fergal J. O'Brien, Anthony S. Weiss, Claire Brougham

Articles

Elastic fibres play a key role in bodily functions where fatigue resistance and elastic recovery are necessary while regulating phenotype, proliferation and migration in cells. While in vivo elastic fibres are created at a late foetal stage, a major obstacle in the development of engineered tissue is that human vascular smooth muscle cells (hVSMCs), one of the principal elastogenic cells, are unable to spontaneously promote elastogenesis in vitro. Therefore, the overall aim of this study was to activate elastogenesis in vitro by hVSMCs seeded in fibrin, collagen, glycosaminoglycan (FCG) scaffolds, following the addition of recombinant human tropoelastin. This combination …

Mind The Gap: Exploring The Challenges And Opportunities For Social Enterprise In Vietnam, Paul Umfreville, Christine Bonnin

Articles

Social enterprise is a maturing area of activity within the development sector, and in Vietnam the sector has expanded significantly over the last thirty years, providing social services to communities and individuals experiencing socio-economic exclusion. Initially growing in a legislative vacuum, social enterprise currently appears to be flourishing following recognition by the state. However, the sector now faces new challenges as it matures. With Vietnam’s attainment of middle-income status, the international development funding previously available is now limited and the focus is on capacity and viability. Based on findings from interviews with representatives from a wide range of social enterprises …

Mapping The Light Fantastic At Newgrange, Frank Prendergast, Clare Tuffy, John Lalor, Claire Breen, Sinéad Gargan

Articles

THE WORLD HERITAGE PROPERTY of Brú na Bóinne attracts thousands of visitors from Ireland and around the globe, many drawn by the remarkable winter solstice phenomenon, when the rising sun’s rays illuminate the burial chamber. During 2020 it became clear that public health measures to combat the global pandemic were going to preclude visitor access to the chamber of the Great Mound of Newgrange, including during the annual winter solstice celebrations. When the government agencies OPW and NMS discussed how to manage Newgrange and the solstice during the restrictions, Clare Tuffy, Manager of Visitor Services at Brú na Bóinne, suggested …

Electrohydrodynamic Printing Of A Dielectric Elastomer Actuator And Its Application In Tunable Lenses, Liang Jiang, Yuhao Wang, Xueqin Wang, Fanggang Ning, Shipeng Wen, Yanfen Zhou, Shaojuan Chen, Tony Betts, Stephen Jerrams, Fenglei Zhou

Articles

Optical lenses driven by dielectric elastomer (DE) actuators with tunable focal lengths are presented here. They are inspired by the architecture of the crystalline lens and the ciliary muscle of the human eye and have prompted a growing interest. The most commonly used DEs in tunable lenses have often required highly transparent films and also the need to encapsulate clear liquid silicone to act as the lens. There is a restriction on the properties of the tunable lens imposed by materials limitations. Here, the fabrication of a fully 3D printed tunable lens with an inhomogeneous structure is described. It exhibited …

Hyperspectral Spectroscopy To Detect Different Responses Of Two Soybean (Glycine Max) Cultivars To Charcoal Rot (Macrophomina Phaseolina) Toxin, Ameer H. Al-Ahmadi, Arjun Subedi, Ruplal Choudhary, Ahmad Fakhoury, Dennis G. Watson

Articles

Previous studies have confirmed the potential of hyperspectral spectroscopy (HS) to detect charcoal rot toxin effect on soybean (Glycine max). However, there is no evidence that it can differentiate among difference responses to that effect. This research tested the potential of HS (900–2400 nm) to differentiate different responses to charcoal rot effect caused by the fungal pathogen Macrophomina phaseolina. Known susceptible ‘Pharaoh’ and resistant ‘Spencer’ cultivars of soybean seedlings at the V1 stage were tested, and HS reflectance was measured in each treatment at 0 h (just before toxin treatment), 24 h, and 36 h after toxin …

Title Insurance: Protecting Property At What Price?, Stewart E. Sterk

Articles

The real property recording system is designed to protect purchasers and mortgagees against defects in title. Navigating that system is beyond the capacity of most laymen; historically, purchasers hired lawyers and other professionals to identify and eliminate title risks. Institutional lenders, however, sought more protection than a lawyer's opinion could provide, leading to the development of title insurance. Title insurance, unlike most other insurance, is focused not on risk spreading but on risk elimination. By examining title before issuing a policy, a title insurer minimizes the likelihood of a successful claim by an insured whose title turns out to be …

Respecting Autonomy And Enabling Diversity: The Effect Of Eligibility And Enrollment On Research Data Demographics, Kayte Spector-Bagdady, Shengpu Tang, Sarah Jabbour, Nicholson Price, Ana Bracic, Melissa S. Creary, Sachin Kheterpal, Chad M. Brummett, Jenna Wiens

Articles

Many promising advances in precision health and other Big Data research rely on large data sets to analyze correlations among genetic variants, behavior, environment, and outcomes to improve population health. But these data sets are generally populated with demographically homogeneous cohorts. We conducted a retrospective cohort study of patients at a major academic medical center during 2012–19 to explore how recruitment and enrollment approaches affected the demographic diversity of participants in its research biospecimen and data bank. We found that compared with the overall clinical population, patients who consented to enroll in the research data bank were significantly less diverse …

Clearing Opacity Through Machine Learning, W. Nicholson Price Ii, Arti K. Rai

Articles

Artificial intelligence and machine learning represent powerful tools in many fields, ranging from criminal justice to human biology to climate change. Part of the power of these tools arises from their ability to make predictions and glean useful information about complex real-world systems without the need to understand the workings of those systems.

Rees/Aaee Special Focus On Ethics: Introduction By Guest Editor, Shannon Chance, Shannon Chance

Articles

Today, more than ever, we see the significance of ethics in developing and sustaining the built, social, and natural environments around us. We also recognise the need to develop engineering students’ knowledge, skills, and values regarding engineering, innovation, design, production, and the like. Engineers’ actions can have intended as well as unintended consequences, and we as a community need to become more aware of the outcomes and implications of our work. In response to the many topics presented at the REES 2019, the REEN Board selected ethics as the focus for this special issue and joined with AAEE to publish …

Five-Wave Resonances In Deep Water Gravity Waves: Integrability, Numerical Simulations And Experiments, Dan Lucas, Marc Perlin, Dian-Yong Liu, Shane Walsh, Rossen Ivanov, Miguel D. Bustamante

Articles

In this work we consider the problem of finding the simplest arrangement of resonant deep water gravity waves in one-dimensional propagation, from three perspectives: Theoretical, numerical and experimental. Theoretically this requires using a normal-form Hamiltonian that focuses on 5-wave resonances. The simplest arrangement is based on a triad of wave vectors K₁ + K₂ = K₃ (satisfying specific ratios) along with their negatives, corresponding to a scenario of encountering wave packets, amenable to experiments and numerical simulations. The normal-form equations for these encountering waves in resonance are shown to be non-integrable, but they admit an integrable reduction …

Fabrication And Qualitative Analysis Of An Optical Fibre Efpi-Based Temperature Sensor, Fintan Mcguinness, Aidan Clooney, Mohamed Oubaha, Dinesh Babu Duraibabu, M. Mahmood Ali, Gerald Kilkelly, Emma Tobin, Gabriel Leen

Articles

The following presents a comparison of an extrinsic Fabry–Perot interferometer (EFPI)- based temperature sensor, constructed using a novel diaphragm manufacturing technique, with a reference all-glass EFPI temperature sensor. The novel diaphragm was manufactured using polyvinyl alcohol (PVA). The novel sensor fabrication involved fusing a single-mode fibre (SMF) to a length of fused quartz capillary, which has an inner diameter of 132 µm and a 220 µm outer diameter. The capillary was subsequently polished until the distal face of the capillary extended approximately 60 µm beyond that of the single mode fibre. Upon completion of polishing, the assembly is immersed in …

An Extracellular Lipase From Amycolatopsis Mediterannei Is A Cutinase With Plastic Degrading Activity, Yeqi Tan, Gary T. Henehan, Gemma K. Kinsella, Barry J. Ryan

Articles

An extracellular lipase from Amycolatopsis mediteranei (AML) with potential applications in process biotechnology was recently cloned and examined in this laboratory. In the present study, the 3D structure of AML was elucidated by comparative modelling. AML lacked the ‘lid’ structure observed in most true lipases and shared similarities with plastic degrading enzymes. Modelling and substrate specificity studies showed that AML was a cutinase with a relatively exposed active site and specificity for medium chain fatty acyl moieties.

AML rapidly hydrolysed the aliphatic plastics poly(ε-caprolactone) and poly(1,4-butylene succinate) extended with 1,6-diisocyanatohexane under mild conditions. These plastics are known to be slow …

In Silico And In Vitro Screening For Potential Anticancer Candidates Targeting Gpr120, Ajay Pal, James Curtin, Gemma K. Kinsella

Articles

The G-protein coupled receptor - GPR120 has recently been implicated as a novel target for colorectal cancer (CRC) and other cancer managements. In this study, a homology model of GPR120S (short isoform) was generated to identify potential anti-cancer compounds targeting the GPR120 receptor using a combined in silico docking-based virtual screening (DBVS), structure-activity relationships (SAR) and in vitro screening approach. SPECS database of synthetic chemical compounds (~350,000) was screened using the developed GPR120S model to identify molecules binding to the orthosteric binding pocket followed by an AutoDock SMINA rigid-flexible docking protocol. The best 13 hit molecules were then tested in …

Seaweed Polysaccharide In Food Contact Materials (Active Packaging, Intelligent Packaging, Edible Films, And Coatings), Kalpani Perera, Shubham Sharma, Dileswar Pradhan, Amit Jaiswal, Swarna Jaiswal

Articles

Food contact materials (FCMs) are materials that come in contact with food products such as food packaging which play a significant role in food quality and safety. Plastic, which is a major food packaging material, harms the ecosystem, wildlife, and the environment. As a result, numerous researches have been in progress on alternative polymers, which have similar properties as plastic but are also environmentally friendly (biodegradable). In recent years, the utilization of seaweed polysaccharides has piqued interest due to their biodegradability, non-toxicity, antioxidant capabilities, and excellent film formation ability. However, it has a number of drawbacks such as low tensile …

Seaweeds Polysaccharides In Active Food Packaging: A Review Of Recent Progress, Carina Dietz, Shubham Sharma, Amit Jaiswal, Swarna Jaiswal

Articles

Background

Due to its short lifetime, food packaging leads to a rapid accumulation of plastic in our surroundings and thereby also has a huge impact on environmental pollution. To reduce these effects and create a more sustainable approach towards food packaging, biodegradable and biobased polymers have been developed and are emerging on the market.

Scope and approach

This review provides the current state of research regarding active packaging and the incorporation of seaweed into food packaging. Further, it summarises the resulting consequences of the seaweed incorporation on mechanical, physical, thermal, antioxidant, antimicrobial, and chemical properties, as well as the release …

Distinct Chemistries Define The Diverse Biological Effects Of Plasma Activated Water Generated With Spark And Glow Plasma Discharges, Evanthia Tsoukou, Maxime Delit, Louise Treint, Paula Bourke, Daniela Boehm

Articles

The spread of multidrug-resistant bacteria poses a significant threat to human health. Plasma activated liquids (PAL) could be a promising alternative for microbial decontamination, where different PAL can possess diverse antimicrobial efficacies and cytotoxic profiles, depending on the range and concentration of their reactive chemical species. In this research, the biological activity of plasma activated water (PAW) on different biological targets including both microbiological and mammalian cells was investigated in vitro. The aim was to further an understanding of the specific role of distinct plasma reactive species, which is required to tailor plasma activated liquids for use in applications where …

Biomolecules As Model Indicators Of In Vitro And In Vivo Cold Plasma Safety, Caitlin Heslin, Daniela Boehm, Brendan F. Gilmore, Julianne Megaw, Theresa A. Freeman, Noreen Hickok, Patrick J. Cullen, Paula Bourke

Articles

The potential applications for cold plasma in medicine are extensive, from microbial inactivation and induction of apoptosis in cancer cells to stimulating wound healing and enhancing the blood coagulation cascade. The safe bio-medical application of cold plasma and subsequent effect on complex biological pathways requires precision and a distinct understanding of how physiological redox chemistry is manipulated. Chemical modification of biomolecules such as carbohydrates, proteins, and lipids treated with cold plasma have been characterized, however, the context of how alterations of these molecules affect cell behavior or in vivo functionality has not been determined. Thus, this study examines the cytotoxic …

Inactivation Efficacy Of Atmospheric Air Plasma And Airborne Acoustic Ultrasound Against Bacterial Bioflms, Apurva Patange, Jeremy Simpson, James Curtin, Catherine Burgess, P.J. Cullen, Brijesh Tiwari

Articles

Bioflms are complex microbial communities that present serious contamination risks to our environment and health. In this study, atmospheric air plasma and airborne acoustic ultrasound technology were applied to inactivate Escherichia coli and Listeria innocua bioflms. Both technologies were efcient in controlling, or completely inactivating, the target bacterial bioflms. Viability and metabolic assays, along with microscopy analysis, revealed that atmospheric air plasma and airborne acoustic ultrasound damaged both the bacterial bioflm cells and its structural integrity. Scanning electron microscopy images highlighted the disruption of the bioflms and pore formation in bacterial cells exposed to both the plasma and acoustic treatments. …

Comparing Passenger Satisfaction, Employees’ Perspective And Performance On Quality And Safety Indicators: A Field Study, Luca D’Alonzo, Maria Chiara Leva, Edgardo Bucciarelli

Articles

This paper aims to analyze the impact that different attributes related to a Regional Airport service and the socio-economic factors of the passengers have on the passenger’s overall satisfaction. The study also compared passenger and employee satisfaction in relation to the service offered by the airport, to identify possible critical areas of improvement. An Ordinal Logistic Regression (OLR) approach was used to model how the attributes considered for qualifying airport services and the socio-economic variables impact the predicted variable (i.e., passenger satisfaction). Furthermore, the results were triangulated to include quality and safety performance indicators as an objective anchor point for …

Computational Solutions Based On Bayesian Networks To Hierarchize And To Predict Factors Influencing Gender Fairness In The Transport System: Four Use Cases, Gemma Dolores Molero, Sara Poveda-Reyes, Ashwani Kumar Malviya Ashwani Kumar Malviya, Elena García-Jiménez, Maria Chiara Leva, Francisco Enrique Santarremigia

Articles

: Previous studies have highlighted inequalities and gender differences in the transport system. Some factors or fairness characteristics (FCs) strongly influence gender fairness in the transport system. The difference with previous studies, which focus on general concepts, is the incorporation of level 3 FCs, which are more detailed aspects or measures that can be implemented by companies or infrastructure managers and operators in order to increase fairness and inclusion in each use case. The aim of this paper is to find computational solutions, Bayesian networks, and analytic hierarchy processes capable of hierarchizing level 3 FCs and to predict by simulation …

Cold Plasma For Insect Pest Control: Tribolium Castaneum Mortality And Defense Mechanisms In Response To Treatment, Dana Ziuzina, Robin Van Cleynenbreugel, Paula Bourke

Articles

The insecticidal properties and mechanisms of high-voltage air-based atmospheric cold plasma using a contained dielectric barrier discharge reactor were investigated against Tribolium castaneum as an important bio-contaminant in stored grains spoilage. The mortality of 95.0%–100% for preadult stages can be achieved within seconds of treatment, but longer plasma exposure (5 min) is required to kill adult insects. Cold plasma treatment reduces both the respiration rate and the weight of insects and affects the levels of oxidative stress markers in adult populations. Sufficient toxicity is achievable through plasma process control in air to address the range of insect lifecycle stages that …

Influence Of Molecular Weight Fractionation On The Antimicrobial And Anticancer Properties Of A Fucoidan Rich-Extract From The Macroalgae Fucus Vesiculosus, Eduarda M. Cabral, Julie Mondala, Márcia Oliveira, Joanna Przyborska, Stephen Fitzpatrick, Dilip K. Rai, Saravana Periaswamy Sivagnanam, Marco Garcia-Vaquero, Denis O'Shea, Michael Devereux, Brijesh K. Tiwari, James Curtin

Articles

The objective of this study was to investigate the antimicrobial and anticancer properties of a fucoidan extract and subsequent fractions isolated from the macroalgae Fucus vesiculosus. The fractions obtained (>300 kDa,kDa,kDa,kDa) could inhibit the growth of B. subtilis, E. coli, L. innocua and P. fluorescens when assayed at concentrations between 12,500 and 25,000 ppm. The bacterial growth was monitored by optical density (OD) measurements (600 nm, 24 h) at 30 °C or 37 °C, depending upon on the strain used. The extracted fractions were also tested for cytotoxicity against brain glioblastoma cancer cells using the Alamar Blue assay for …