Digital Commons Network^™

Enhancing The Visibility Of Vernier Effect In A Tri-Microfiber Coupler Fiber Loop Interferometer For Ultrasensitive Refractive Index And Temperature Sensing, Fangfang Wei, Dejun Liu, Zhe Wang, Zhuochen Wang, Gerald Farrell, Qiang Wu, Gang-Ding Peng, Yuliya Semenova

Articles

In this paper a Vernier effect based sensor is analyzed and demonstrated experimentally in a tri-microfiber coupler (Tri-MFC) and polarization-maintaining fiber (PMF) loop interferometer (Tri-MFC-PMF) to provide ultrasensitive refractive index and temperature sensing. The main novelty of this work is an analysis of parameters of the proposed Tri-MFC-PMF with the objective of determining the conditions leading to a strong Vernier effect. It has been identified by simulation that the Vernier effect is a primary factor in the design of Tri-MFC-PMF loop sensing structure for sensitivity enhancement. It is furthermore demonstrated experimentally that enhancing the visibility of the Vernier spectrum in …

Safety Of Vitamin D2 Mushroom Powder As A Novel Food Pursuant To Regulation (Eu) 2015/2283, John Kearney, Dominique Turck, Jacqueline Castenmiller, Stefaan De Henauw

Articles

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on vitamin D2 mushroom powder as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is an ingredient produced from Agaricus bisporus mushrooms that have been exposed to ultraviolet (UV) light to induce the conversion of provitamin D2 (ergosterol) to vitamin D2 (ergocalciferol). The NF contains concentrations of vitamin D provided by vitamin D2 in the ranges of 1,000–1,300 lg/g. The information provided on the manufacturing process, composition and specifications of the NF …

Numbers, Patrick Barry

Articles

Numbers can be numbing. Depend too much on them to make your case, pitch your product, or tell your story, and you risk losing your audience. This essay offers a way to way to use numbers—both large and small—in a manner that is at once more compelling and more concrete.

Riluzole Attenuates Glutamatergic Tone And Cognitive Decline In Aβpp/Ps1 Mice., Kevin N Hascup, Caleigh A Findley, Jesse Britz, Nahayo Esperant-Hilaire, Sarah O Broderick, Kristin Delfino, Shelley Tischkau, Andrzej Bartke, Erin R Hascup

Articles

We have previously demonstrated hippocampal hyperglutamatergic signaling occurs prior to plaque accumulation in AβPP/PS1 mice. Here, we evaluate 2-Amino-6-(trifluoromethoxy) benzothiazole (riluzole) as an early intervention strategy for Alzheimer's disease (AD), aimed at restoring glutamate neurotransmission prior to substantial Beta amyloid (Aβ) plaque accumulation and cognitive decline. Male AβPP/PS1 mice, a model of progressive cerebral amyloidosis, were treated with riluzole from 2-6 months of age. Morris water maze, in vivo electrochemistry, and immunofluorescence were performed to assess cognition, glutamatergic neurotransmission, and pathology, respectively, at 12 months. Four months of prodromal riluzole treatment in AβPP/PS1 mice resulted in long-lasting procognitive effects and …

Assessment And Evaluation Of Student Learning Through A Project-Based Assignment On Note By Note Cooking, Roisin Burke, Pauline Danaher

Articles

Many innovative teaching and learning methods are used in higher level education including projectbased learning (PBL). Since 2012 a PBL assignment project has been undertaken by master students of the Advanced Molecular Gastronomy module at Technological University Dublin (TU Dublin). The aim is to stimulate student learning and creativity by using Note by Note cooking in a PBL assignment while at the same time complying with the requirements of the annual International Note by Note contest which is held in Paris, France. Direct and indirect assessment methods were used to assign individual grades and to gather student feedback about the …

Investigation Of Surrogate Biomarkers Associated With Macular Pigment Status In A Group Of Older Irish Adults, Grainne Scanlon, John S. Butler, Daniel Mccartney, Ekaterina Lostutova, Rose Anne Kenny, James Loughman

Articles

SIGNIFICANCE: Macular pigment (MP) confers potent antioxidant and anti-inflammatory effects at the macula; however, its optical density in the eye is not routinely measured in clinical practice.

PURPOSE: This study explored a range of surrogate biomarkers including anthropometric, clinical, and plasma measures that may be associated with lower MP optical density (MPOD).

METHODS: Two thousand five hundred ninety-four subjects completed a full MP assessment as part of wave 1 of The Irish Longitudinal Study of Aging. Macular pigment optical density was measured using customized heterochromatic flicker photometry. Clinical (blood pressure), plasma (lipoproteins, inflammatory markers), and anthropometric (waist, hip, height, weight) …

Children’S Ethno-National Flag Categories In Three Divided Societies, Edona Maloku, Jocelyn B. Dautel, Ana Tomovska Misoska, Laura K. Taylor

Articles

Flags are conceptual representations that can prime nationalism and allegiance to one’s group. Investigating children’s understanding of conflict-related ethno-national flags in divided societies sheds light on the development of national categories. We explored the development of children’s awareness of, and preferences for, ethno-national flags in Northern Ireland, Kosovo, and the Republic of North Macedonia. Children displayed early categorization of, and ingroup preferences for, ethno-national flags. By middle-childhood, children’s conflict-related social categories shaped systematic predictions about other’s group-based preferences for flags. Children of minority-status groups demonstrated more accurate flag categorization and were more likely to accurately infer others’ flag preferences. While …

High Seas Governance: Gaps And Challenges, Bernard H. Oxman

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No abstract provided.

Isolation And Characterization Of A Novel Thermo-Solvent-Stable Lipase From Pseudomonas Brenneri And Its Application In Biodiesel Synthesis, Priyanka Priyanka, Gemma K. Kinsella, Gary T. Henehan, Barry J. Ryan

Articles

Pseudomonads are one of the most studied species of bacteria as they display remarkable metabolic and physiological versatility. This enables them to colonize a wide variety of terrestrial and aquatic habitats, generating biotechnologically interesting enzymes. Here, the partial purification and characterization of a novel, extracellularly-produced, lipase from Pseudomonas brenneri is described. The partially purified lipase was active over a broad pH range (5.0–9.0) and was stable at 70 °C for 45 min. The lipase displayed significant stability, and in some cases activation, in the presence of organic solvents with log P≥2.0. Such stability characteristics indicated that this lipase could potentially …

Exploration Of The Neisseria Resistome Reveals Resistance Mechanisms In Commensals That May Be Acquired By N. Gonorrhoeae Through Horizontal Gene Transfer, Michael A. Fiore, Jordan C. Raisman, Narayan H. Wong, André O. Hudson, Crista B. Wadsworth

Articles

Nonpathogenic Neisseria transfer mutations encoding antibiotic resistance to their pathogenic relative Neisseria gonorrhoeae. However, the resistance genotypes and subsequent phenotypes of nonpathogens within the genus have been described infrequently. Here, we characterize the minimum inhibitory concentrations (MICs) of a panel of Neisseria (n = 26)—including several commensal species—to a suite of diverse antibiotics. We furthermore use whole genome sequencing and the Comprehensive Antibiotic Resistance Database Resistance Gene Identifier (RGI) platform to predict putative resistance-encoding mutations. Resistant isolates to all tested antimicrobials including penicillin (n = 5/26), ceftriaxone (n = 2/26), cefixime (n = 3/26), tetracycline (n = 10/26), azithromycin (n …

A Synthesis Of The Effects Of Cheatgrass Invasion On Us Great Basin Carbon Storage, R. Chelsea Nagy, Emily J. Fusco, Jennifer K. Balch, John T. Finn, Adam Mahood, Jenica M. Allen, Bethany A. Bradley

Articles

1. Non-native, invasive Bromus tectorum (cheatgrass) is pervasive in sagebrush ecosystems in the Great Basin ecoregion of the western United States, competing with native plants and promoting more frequent fires. As a result, cheatgrass invasion likely alters carbon (C) storage in the region. Many studies have measured C pools in one or more common vegetation types: native sagebrush, invaded sagebrush and cheatgrass-dominated (often burned) sites, but these results have yet to be synthesized.
2. We performed a literature review to identify studies assessing the consequences of invasion on C storage in above-ground biomass (AGB), below-ground biomass (BGB), litter, organic soil and total …

Practical Model For Improved Classification Of Trace Chemical Residues On Surfaces In Active Spectroscopic Measurements, Cara P. Murphy, John P. Kerekes, Derek A. Wood, Anish K. Goyal

Articles

No abstract provided.

Practical Model For Improved Classification Of Trace Chemical Residues On Surfaces In Active Spectroscopic Measurements, Cara P. Murphy, John Kerekes, Derek Wood, Anish Goyal

Articles

Trace chemical detection and classification in stand-off reflection-based spectro- scopic data is challenging due to the variability of measured data and the lack of physics-based models that can accurately predict spectra. Most available models assume that the chemical takes the form of spherical particles or uniform thin films. A more realistic chemical presentation that could be encountered is that of a nonuniform chemical film that is deposited after evaporation of the solvent that contained the chemical. We present an improved signature model for this type of solid film. The proposed model, called sparse transfer matrix, includes a log-normal distribution of …

Legitimacy And Agency Implementation Of Title Ix, Samuel R. Bagenstos

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Title IX of the Education Amendments of 1972 prohibits sex discrimination by programs receiving federal education funding. Primary responsibility for administering that statute lies in the Office for Civil Rights of the Department of Education (OCR). Because Title IX involves a subject that remains highly controversial in our polity (sex roles and interactions among the sexes more generally), and because it targets a highly sensitive area (education), OCR’s administration of the statute has long drawn criticism. The critics have not merely noted disagreements with the legal and policy decisions of the agency, however. Rather, they have attacked the agency’s decisions …

An Online Interactive Video Vignette That Helps Students Learn Key Concepts Of Fermentation And Respiration, Jean A. Cardinale, Dina L. Newman, L. Kate Wright

Articles

Topics related to energy transformation and metabolism are important parts of an undergraduate biology curriculum, but these are also topics that students traditionally struggle with. To address this, we have created a short online Interactive Video Vignette (IVV) called To Ferment or Not to Ferment: That is the Question. This IVV is designed to help students learn important ideas related to cellular respiration and metabolism. Students in various courses across four institutions were assigned the IVV as an out-of-class preinstruction homework assignment. To test the effectiveness of this IVV on student learning, we collected and analyzed data from questions embedded …

Treatment Longevity And Changes In Surface Fuel Loads After Pinyon–Juniper Mastication, Samuel S. Wozniak, Eva K. Strand, Timothy R. Johnson, April Hulet, Bruce A. Roundy, Kert Young

Articles

In the Intermountain West, land managers masticate pinyon pine (Pinus spp.) and juniper (Juniperus spp.) trees that have encroached sagebrush steppe communities to reduce canopy fuels, alter potential fire behavior, and promote growth of understory grasses, forbs, and shrubs. At three study sites in Utah, 45 sampling plots spanning a range of tree cover from 5% to 50% were masticated. We measured surface fuel load components three times over a 10‐yr period. We also measured tree cover, density, and height as indicators of treatment longevity. Changes in these variables were analyzed across the range of pre‐treatment tree cover …

Characterization And Antimicrobial Activity Of Biodegradable Active Packaging Enriched With Clove And Thyme Essential Oil For Food Packaging Application, Shubham Sharma, Sandra Barkauskaite, Brendan Duffy, Amit Jaiswal, Swarna Jaiswal

Articles

Bioactive packaging contains natural antimicrobial agents, which inhibit the growth of microorganisms and increase the food shelf life. Solvent casting method was used to prepare the Poly (lactide)-Poly (butylene adipate-co-terephthalate) (PLA-PBAT) film incorporated with the thyme oil and clove oil in various concentrations (1 wt%, 5 wt% and 10 wt%). The clove oil composite films depicted less green and more yellow as compared to thyme oil composite films. Clove oil composite film has shown an 80% increase in the UV blocking efficiency. The tensile strength (TS) of thyme oil and clove oil composite film decreases from 1.35 MPs (control film) …

Multi‑View Clustering For Multi‑Omics Data Using Unifed Embedding, Mohammed Hasanuzzaman, Sayantan Mitra, Sriparna Saha

Articles

In real world applications, data sets are often comprised of multiple views, which provide consensus and complementary information to each other. Embedding learning is an effective strategy for nearest neighbour search and dimensionality reduction in large data sets. This paper attempts to learn a unified probability distribution of the points across different views and generates a unified embedding in a low-dimensional space to optimally preserve neighbourhood identity. Probability distributions generated for each point for each view are combined by conflation method to create a single unified distribution. The goal is to approximate this unified distribution as much as possible when …

Interactive Video Vignettes (Ivvs) To Help Students Learn Genetics Concepts, Dina L. Newman, Jean Cardinale, L Kate Wright

Articles

any video resources exist to teach Mendelian genetics, but most consist of passive delivery of information rather than active construction of knowledge by users. We have created two interactive video vignettes (IVVs) that can be used together or separately to introduce students to core concepts of genetics, using principles of active learning (e.g., elicit-confront-resolve, directed feedback, reflection). These online resources are free and can be assigned as homework for students to complete outside of class. Each IVV features a realistic scenario of undergraduate students investigating genetic phenomena by collecting and analyzing data. During the IVVs, the user is integrated into …

Does Sars-Cov-2 Infection Cause Chronic Neurological Complications?, Erin R Hascup, Kevin N Hascup

Articles

The current pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has created an unparalleled health crisis. Besides the acute respiratory infection, CoVs are neuroinvasive causing additional inflammation and neurodegeneration. This is likely also true of SARS-CoV-2 given reports of neurological manifestations in coronavirus disease 2019 (COVID-19) positive patients. Older adults > 65 years of age constitute a high-risk group prone to severe infection and death. Despite the higher mortality rate, a majority of cases are expected to recover and survive from this viral outbreak. But, the long-term consequences of SARS-CoV-2 neuroinfection are unknown. We discuss these potential chronic changes to …

Living With Machines. Ethical Implications And Imaginative Agency As Local Tactics Of Dwelling And Resistance In Everyday Interactions With Artificial Intelligence, Ester Toribio-Roura

Articles

With the widespread of the Internet of things (IoT), algorithms are increasingly managing our everyday life. From navigating our way in cities to keeping track of our health, artificial intelligence has been beneficial to us in many ways. However, its algorithms can also be detrimental as a consequence of biased human programming. The result is that while technological progress delivers more and more human-like artificial intelligence, humans become dehumanised and therefore, disempowered in their everyday interactions with artificial intelligence.The solution(s) is not single-handed and calls for combined interventions at the macro and micro levels. Whilst reviewing recent top-down developments on …

"I Learned That I Am Loved": Older Adults And Undergraduate Students Mutually Benefit From An Interprofessional Service-Learning Health Promotion Program., Britteny M. Howell, Leslie C. Redmond, Samantha Wanner

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No abstract provided.

Towards Refining Alzheimer's Disease Into Overlapping Subgroups, Erin R. Hascup, Kevin N Hascup

Articles

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by progressive anterograde amnesia, cerebral atrophy, and eventual death. Current treatment has limited efficacy and cannot decelerate the disease progression. Clinical trials targeting the removal of the neuropathological hallmarks of AD, including accu- mulation of amyloid plaques or neurofibrillary tangles, have failed to modify disease progression. Without new or innovative hypotheses, AD is poised to become a public health crisis within this decade. We present an alternative hypothesis—that AD is the result of multiple interrelated causalities. The intention of this manuscript is to initiate a discussion regarding these multiple causalities and …

Coeliac Disease Pathogenesis: The Uncertainties Of A Well-Known Immune Mediated Disorder, Greg Byrne, Margaret Dunne, Con Feighery, Fernando Chirdo

Articles

Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive immune system in response to gluten peptides. Despite detailed knowledge of these adaptive immune mechanisms, the complete series of pathogenic events responsible for development of the tissue lesion remains less certain. This review contributes to the field by discussing additional mechanisms which may also contribute to pathogenesis. These include the production of cytokines such as interleukin-15 by intestinal epithelial cells and local antigen presenting cells as …

Covid-19, Single-Sourced Diagnostic Tests, And Innovation Policy, Deb Chaarushena, Osman Moneer, Nicholson W. Price Ii

Articles

At the heart of the United States, disastrous response to the Covid-19 pandemic is a failure of diagnostic testing. That something so fundamental to medical care could be so botched evokes incredulity. From primary care offices to critical care settings, every patient encounter begins with a diagnostic workup. Diagnostic testing tools are key parts of the physician’s toolkit, and confirmatory testing is essential. But in the greatest public health challenge of the 21st century, the failures of diagnostic testing have been laid entirely bare.

What's Left Of The Affordable Care Act?, Helen Levy, Andrew Ying, Nicholas Bagley

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We assess the progress of the Affordable Care Act a decade after it became law. Although most of it remains intact, some parts have been repealed and others have not been implemented as expected. We review how and why the law has aged. Legal challenges have done less damage than is commonly appreciated, with the exception of the Supreme Court case that thwarted full expansion of Medicaid. Most of the important changes have other sources. Some parts were born to fail. Others were dismantled in response to interest-group pressure. Still others have failed to thrive for any number of reasons. …

Enzymatic In-Situ Transesterification Of Neutral Lipids From Simulated Wastewater Cultured Chlorella Emersonii And Pseudokirchneriella Subcapitata To Sustainably Produce Fatty Acid Methyl Esters, Priyanka Priyanka, Gemma K. Kinsella, Gary Henehan, Barry J. Ryan

Articles

Alternative, more sustainable and environmentally positive, sources of energy are one of the current global challenges. One approach to achieving more sustainable sources of energy is to use waste from one system as a raw material for energy production, following the circular biosystem philosophy. This study successfully adopted this approach whereby microalgae strains Chlorella emersonii and Pseudokirchneriella subcapitata were bioprospected and metabolically engineered in simulated wastewater supplemented with glucose to produce neutral lipids. Using a two-step cultivation approach neutral lipid content was enhanced in Chlorella emersonii and Pseudokirchneriella subcapitata biomass. Via in-situ transesterification, these neutral lipids were subsequently bioconverted to …

Transgender Labour Market Outcomes: Evidence From The Us, Klavs Ciprikis, Damien Cassells, Jenny Berrill

Articles

Alternative labour market outcomes for men and women have been studied extensively in past literature. However, existing studies fail to directly compare labour market differences between transgender and non-transgender people. We utilize data from the 2015 Behavioral Risk Factor Surveillance Sys- tem in the United States to examine employment and wage differentials between transgender persons and non- transgender people using the Fairlie decomposition method of 2005. Our findings suggest that transgender people are less likely than non-transgender people to be employed, and are more likely than non-transgender people to receive lower wages. While some of the difference in employment and …

Questions Concerning Attention And Stiegler’S Therapeutics, Noel Fitzpatrick

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The article sets out to develop the concept of attention as a key aspect to building the possible therapeutics that Bernard Stiegler’s recent works have pointed to (The Automatic Society, 2016, The Neganthropocene, 2018 and Qu’appelle-t-on Panser, 2018). The therapeutic aspect of pharmacology takes place through processes that are neganthropic; therefore, which attempt to counteract the entropic nature of digital technologies where there is flattening out to the measurable and the calculable of Big Data. The most obvious examples of this flattening out can be seen in relation to the use of natural language processing technologies for …

Minds Without Spines: Evolutionarily Inclusive Animal Ethics., Irina Mikhalevich, Russell Powell

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Invertebrate animals are frequently lumped into a single category and denied welfare protections despite their considerable cognitive, behavioral, and evolutionary diversity. Some ethical and policy inroads have been made for cephalopod molluscs and crustaceans, but the vast majority of arthropods, including the insects, remain excluded from moral consideration. We argue that this exclusion is unwarranted given the existing evidence. Anachronistic readings of evolution, which view invertebrates as lower in the scala naturae, continue to influence public policy and common morality. The assumption that small brains are unlikely to support cognition or sentience likewise persists, despite growing evidence that arthropods have …