Digital Commons Network^™

Third Parties With Benefits, Casey E. Faucon

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No abstract provided.

(Im)Mutable Race?, Deepa Das Acevedo

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No abstract provided.

Collaborations In Environmental Initiatives For An Effective Gover- Nance Of Social-Ecological Systems: What The Scientific Literature Suggests., Elena Andriollo, Alberto Caimo, Laura Secco, Elena Pisani

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Moving from the scientific literature on evaluation of environmental projects and programs, this study identifies how and under which conditions collaborations are considered effective for adaptive gover- nance of SES. The method adopted is a systematic literature review based on the quantitative and qualitative analysis of 56 articles selected through specific queries on the SCOPUS database and published from 2004 to 2020. Results of the quantitative analysis underline conditions able to make collaborations effective for adaptive governance of SES: the importance of transdisciplinary research tackling both environmental and social sciences, the perceived urgency of stakeholders to tackle environmental challenges and …

Silver(I) And Copper(Ii) Complexes Of 1,10-Phenanthroline-5,6-Dione Against Phialophora Verrucosa: A Focus On The Interaction With Human Macrophages And Galleria Mellonella Larvae, Marcela Q. Granato, Thaís P. Mello Thaís P. Mello, Renata S Nascimento, Marcos D. Pereira, Thabatta L.S.A. Rosa, Maria C.V. Pessolani, Malachy Mccann Malachy Mccann, Michael Devereux, Marta H. Branquinha

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Phialophora verrucosa is a dematiaceous fungus that causes mainly chromoblastomycosis, but also disseminated infections such as phaeohyphomycosis and mycetoma. These diseases are extremely hard to treat and often refractory to current antifungal therapies. In this work, we have evaluated the effect of 1,10-phenanthroline-5,6-dione (phendione) and its metal-based complexes, [Ag (phendione)2]ClO4 and [Cu(phendione)3](ClO4)2.4H2O, against P. verrucosa, focusing on (i) conidial viability when combined with amphotericin B (AmB); (ii) biofilm formation and disarticulation events; (iii) in vitro interaction with human macrophages; and (iv) in vivo infection of Galleria mellonella larvae. The combination of AmB with each of the test compounds promoted …

Food Contact Surfaces: Challenges, Legislation And Solutions, Shubham Sharma, Amit Jaiswal, Brendan Duffy, Swarna Jaiswal

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Food contact surfaces (FCSs) include all surfaces that may come in contact with the food during production, processing, and packaging. Food processing industries encounter several challenges due to its microbial interaction with the FCSs, such as cross-contamination of pathogenic microorganisms or allergens in food, formation of biofilm, biodeterioration of food contact surface leads to food with reduced shelf-life and quality. A legal EU framework provides the fundamental postulates for the safety and inertness of all Food Contact Materials (FCMs). Legislations have an important role in providing regulatory guidance on the quality assurance systems and verifying their implementation as a means …

Addressing Health Literacy For Improved Outcomes: A Focus On Pregnancy, S.L. Killeen, I. Brown, A.A. Geraghty, F.M. Mcauliffe

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Health literacy influences how messages are received and understood by patient or population groups. In Europe, incomprehension of health information is common, affecting the ability of many individuals to make informed decisions about their health. In addition, incomprehension of health information may impact the effectiveness of interventions and subsequently, health outcomes. In this article, we illustrate the importance of health literacy in the context of maternity services, a time during which, health interventions affect both maternal and child health. Through this, we suggest that health literacy should be recognised in healthcare settings as a tool to facilitate behaviour change. To …

The Role Of Demographic And Clinical Characteristics On Risk Of Covid-19 Related Infection And Mortality, A. O'Shea, M. Youssef, M. Connolly, A. Al Lawati, S.I. Shah, S. Walsh, D. Mccartney, J. Faul

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Since the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) which causes Covid-19, global health systems have struggled to cope with the rising number of related infections, acute admissions and mortalities. Poorer clinical outcomes have been observed amongst older patients with Covid-19 and males, and in those who are obese or who have darker skin(1) . Additionally, poorer outcomes including increased mortality have been associated with low vitamin D status(2,3) . The current observational study aimed to elucidate the association between patient demographic, anthropometric, clinical and biometric characteristics and Covid-19 disease severity and mortality.

Advancing Our Understanding Of Corneal Herpes Simplex Virus-1 Immune Evasion Mechanisms And Future Therapeutics, Emily Greenam, Sophie Gallagher, Rana Khalil, Conor C. Murphy, Joan Ní Gabhann-Dromgoole

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Herpes stromal keratitis (HSK) is a disease that commonly affects the cornea and external eye and is caused by Herpes Simplex Virus type 1 (HSV-1). This virus infects approximately 66% of people worldwide; however, only a small portion of these people will develop symptoms in their lifetime. There is no cure or vaccine available for HSV-1; however, there are treatments available that aim to control the inflammation caused by the virus and prevent its recurrence. While these treatments are beneficial to those suffering with HSK, there is a need for more effective treatments to minimise the need for topical steroids, …

Associations Between Home Environment, Children’S And Parents’ Characteristics And Children’S Tv Screen Time Behavior, Carolina Bassu, Clare Corish, John Kearney

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In Ireland, television (TV) screen time is a highly prevalent sedentary behavior among children aged less than five years. Little is known about the influence of parental rules and policies or screen time availability and accessibility within the home on children's TV screen time behaviors. This cross-sectional study aimed to examine the extent to which parents' sociodemographic and sedentary behaviors are associated with children's TV screen time; and to determine the associations between parents' rules and practices, home physical environment and children's daily TV viewing. Three hundred and thirty-two children aged 3-5 years and their parents participated in the study. …

Inactivation Efficacy Of Atmospheric Air Plasma And Airborne Acoustic Ultrasound Against Bacterial Bioflms, Apurva Patange, Jeremy Simpson, James Curtin, Catherine Burgess, P.J. Cullen, Brijesh Tiwari

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Bioflms are complex microbial communities that present serious contamination risks to our environment and health. In this study, atmospheric air plasma and airborne acoustic ultrasound technology were applied to inactivate Escherichia coli and Listeria innocua bioflms. Both technologies were efcient in controlling, or completely inactivating, the target bacterial bioflms. Viability and metabolic assays, along with microscopy analysis, revealed that atmospheric air plasma and airborne acoustic ultrasound damaged both the bacterial bioflm cells and its structural integrity. Scanning electron microscopy images highlighted the disruption of the bioflms and pore formation in bacterial cells exposed to both the plasma and acoustic treatments. …

Salmonella, Food Safety And Food Handling Practices, Olugbenga Ehuwa, Amit Jaiswal, Swarna Jaiswal

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: Salmonellosis is the second most reported gastrointestinal disorder in the EU resulting from the consumption of Salmonella-contaminated foods. Symptoms include gastroenteritis, abdominal cramps, bloody diarrhoea, fever, myalgia, headache, nausea and vomiting. In 2018, Salmonella accounted for more than half of the numbers of foodborne outbreak illnesses reported in the EU. Salmonella contamination is mostly associated with produce such as poultry, cattle and their feeds but other products such as dried foods, infant formula, fruit and vegetable products and pets have become important. Efforts aimed at controlling Salmonella are being made. For example, legislation and measures put in place reduced …

Distinct Chemistries Define The Diverse Biological Effects Of Plasma Activated Water Generated With Spark And Glow Plasma Discharges, Evanthia Tsoukou, Maxime Delit, Louise Treint, Paula Bourke, Daniela Boehm

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The spread of multidrug-resistant bacteria poses a significant threat to human health. Plasma activated liquids (PAL) could be a promising alternative for microbial decontamination, where different PAL can possess diverse antimicrobial efficacies and cytotoxic profiles, depending on the range and concentration of their reactive chemical species. In this research, the biological activity of plasma activated water (PAW) on different biological targets including both microbiological and mammalian cells was investigated in vitro. The aim was to further an understanding of the specific role of distinct plasma reactive species, which is required to tailor plasma activated liquids for use in applications where …

Influence Of Molecular Weight Fractionation On The Antimicrobial And Anticancer Properties Of A Fucoidan Rich-Extract From The Macroalgae Fucus Vesiculosus, Eduarda M. Cabral, Julie Mondala, Márcia Oliveira, Joanna Przyborska, Stephen Fitzpatrick, Dilip K. Rai, Saravana Periaswamy Sivagnanam, Marco Garcia-Vaquero, Denis O'Shea, Michael Devereux, Brijesh K. Tiwari, James Curtin

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The objective of this study was to investigate the antimicrobial and anticancer properties of a fucoidan extract and subsequent fractions isolated from the macroalgae Fucus vesiculosus. The fractions obtained (>300 kDa,kDa,kDa,kDa) could inhibit the growth of B. subtilis, E. coli, L. innocua and P. fluorescens when assayed at concentrations between 12,500 and 25,000 ppm. The bacterial growth was monitored by optical density (OD) measurements (600 nm, 24 h) at 30 °C or 37 °C, depending upon on the strain used. The extracted fractions were also tested for cytotoxicity against brain glioblastoma cancer cells using the Alamar Blue assay for …

Cold Plasma For Insect Pest Control: Tribolium Castaneum Mortality And Defense Mechanisms In Response To Treatment, Dana Ziuzina, Robin Van Cleynenbreugel, Paula Bourke

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The insecticidal properties and mechanisms of high-voltage air-based atmospheric cold plasma using a contained dielectric barrier discharge reactor were investigated against Tribolium castaneum as an important bio-contaminant in stored grains spoilage. The mortality of 95.0%–100% for preadult stages can be achieved within seconds of treatment, but longer plasma exposure (5 min) is required to kill adult insects. Cold plasma treatment reduces both the respiration rate and the weight of insects and affects the levels of oxidative stress markers in adult populations. Sufficient toxicity is achievable through plasma process control in air to address the range of insect lifecycle stages that …

Plasma-Treated Water Affects Listeria Monocytogenes Vitality And Biofilm Structure, Oliver Handorf

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Plasma-generated compounds (PGCs) such as plasma-processed air (PPA) or plasma-treated water (PTW) offer an increasingly important alternative for the control of microorganisms in hard-to-reach areas found in several industrial applications including the food industry. To this end, we studied the antimicrobial capacity of PTW on the vitality and biofilm formation of Listeria monocytogenes, a common foodborne pathogen.

Ruthenium-Centred Btp Glycoclusters As Inhibitors For Pseudomonas Aeruginosa Biofilm Formation, Ciaran O'Reilly, Salvador Blasco, Bina Parekh, Helen Collins, Gordon Cooke, Thorfinnur Gunnlaugsson, Joseph P. Byrne

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No abstract provided.

Fabrication And Qualitative Analysis Of An Optical Fibre Efpi-Based Temperature Sensor, Fintan Mcguinness, Aidan Clooney, Mohamed Oubaha, Dinesh Babu Duraibabu, M. Mahmood Ali, Gerald Kilkelly, Emma Tobin, Gabriel Leen

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The following presents a comparison of an extrinsic Fabry–Perot interferometer (EFPI)- based temperature sensor, constructed using a novel diaphragm manufacturing technique, with a reference all-glass EFPI temperature sensor. The novel diaphragm was manufactured using polyvinyl alcohol (PVA). The novel sensor fabrication involved fusing a single-mode fibre (SMF) to a length of fused quartz capillary, which has an inner diameter of 132 µm and a 220 µm outer diameter. The capillary was subsequently polished until the distal face of the capillary extended approximately 60 µm beyond that of the single mode fibre. Upon completion of polishing, the assembly is immersed in …

Here You Have To Be Mixing: Collaborative Learning On An Engineering Program In Ireland As Experienced By A Group Of Young Middle Eastern Women, Shannon Chance, Bill Williams

Articles

This research project uses grounded theory to analyze interviews conducted with eight women from Oman and Kuwait. Members of the sample group were studying together at an institute of technology in Dublin, Ireland. The paper reports patterns in 15 interviews collected in the years 2014, 2015, 2016, and 2017 to provide a longitudinal overview of the experience of the learners. During the coding process, three major themes emerged having to do with the experience of learning with others and/or learning in groups. The first theme involved communication within the group and the group's approaches to working together. The second identified …

Feature Fusion Of Raman Chemical Imaging And Digital Histopathology Using Machine Learning For Prostate Cancer Detection, Trevor Doherty, Susan Mckeever, Nebras Al-Attar, Tiarnán Murphy, Claudia Aura, Arman Rahman, Amanda O'Neill,, Stephen P. Finn, Elaine Kay, William M. Gallagher, William G. Watson, Aoife Gowen, Patrick Jackman

Articles

The diagnosis of prostate cancer is challenging due to the heterogeneity of its presentations, leading to the over diagnosis and treatment of non-clinically important disease. Accurate diagnosis can directly benefit a patient’s quality of life and prognosis. Towards addressing this issue, we present a learning model for the automatic identification of prostate cancer. While many prostate cancer studies have adopted Raman spectroscopy approaches, none have utilised the combination of Raman Chemical Imaging (RCI) and other imaging modalities. This study uses multimodal images formed from stained Digital Histopathology (DP) and unstained RCI. The approach was developed and tested on a set …

Socio-Economic Factors Associated With The Incidence Of Shiga-Toxin Producing Escherichia Coli (Stec) Enteritis And Cryptosporidiosis In The Republic Of Ireland, 2008–2017, Eiimear Cleary, Martin Boudou, Coilín Oscar Óhaiseadha, Patricia Garvey, Paul Mckeown, Jean O'Dwyer, Paul Hynds

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The Republic of Ireland (ROI) currently reports the highest incidence rates of Shiga-toxin producing Escherichia coli (STEC) enteritis and cryptosporidiosis in Europe, with the spatial distribution of both infections exhibiting a clear urban/rural divide. To date, no investigation of the role of socio-demographic profile on the incidence of either infection in the ROI has been undertaken. The current study employed bivariate analyses and Random Forest classification to identify associations between individual components of a national deprivation index and spatially aggregated cases of STEC enteritis and cryptosporidiosis. Classification accuracies ranged from 78.2% (STEC, urban) to 90.6% (cryptosporidiosis, rural). STEC incidence was …

Clearing Opacity Through Machine Learning, W. Nicholson Price Ii, Arti K. Rai

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Artificial intelligence and machine learning represent powerful tools in many fields, ranging from criminal justice to human biology to climate change. Part of the power of these tools arises from their ability to make predictions and glean useful information about complex real-world systems without the need to understand the workings of those systems.

Climate-Induced Human Displacement And Conservation Lands, Jessica Owley

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As climate change leads to both internal displacement and mass migrations, we need not only new places for people to live but also new locations for infrastructure projects and other public needs. Some of the most attractive areas for these new land uses are currently unoccupied land, including land set aside for conservation. Numerous laws restrict the availability and possible uses of public conservation land. Individual agreements and property restrictions encumber private conservation land, varying in the ease with which the restrictions can be modified. For example, privately protected areas in the United States are often encumbered with perpetual conservation …

From Overt Threat To Invisible Presence: Discursive Shifts In Representations Of Gender In Menstrual Product Advertising, Valerie Gannon, Olivia Freeman, Rachel Campbell

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The menstrual product brand ‘Always’ and its #LikeAGirl campaign has made headlines for being at the forefront of a menstrual liberation, championing female empowerment and gender equality. This paper utilises a visual discourse analysis approach (Rose, 2016) to explore the discursive shifts in ‘Always’ advertisements over the past four decades. Specifically, the question as to how the construction of menstruation has changed over time in the advertising discourse of the ‘Always’ brand is addressed. Three dominant discourses of menstruation are identified: overt threat, uncontrollable and invisible. These discourses function as strong claims to truth as they reach the everyday life …

The Law Of Emerging Adults, Clare Ryan

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Law tends to divide people into two groups based on age: children and adults. The age of majority provides a bright line between two quite different legal regimes. Minority is characterized by dependency, parental control, incapacity, and diminished responsibility. Adulthood is characterized by autonomy, capacity, and financial and legal responsibility. Over the course of the twentieth century, evolving understandings of adolescence in law and culture produced a staged process of increasing liberty and responsibility up to the age of majority. After eighteen, however, the presumption of adulthood remains strong. Today, a combination of psychological and social factors has extended the …

Unintended Legislative Inertia, Mirit Eyal-Cohen

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Institutional and political forces create strong inertial pressures that make updating legislation a difficult task. As a result, laws often stagnate, leading to the continued existence of obsolete rules and policies that serve long-forgotten purposes. Recognizing this inertial power, legislatures over the last few decades have increasingly relied on a perceived solution -- temporary legislation. In theory, this measure avoids inertia by requiring legislators to choose to extend a law deliberately.

This Article argues that temporary legislation is a double-edged sword. While some temporary laws ultimately expire, many perpetuate through cycles of extension and reauthorization. Temporary legislation often creates its …

Raman Spectral Cytopathology For Cancer Diagnostic Applications, Damien Traynor, Isha Behl, Declan O'Dea, Franck Bonnier, Siobhan Nicholson, Finbar O'Connell, Aoife Maguire, Stephen Flint, Sheila Galvin, Claire M. Healy, Cara M. Martin, John J. O'Leary, Alison Malkin, Hugh J. Byrne, Fiona M. Lyng

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Raman spectroscopy can provide a rapid, label-free, nondestructive measurement of the chemical fingerprint of a sample and has shown potential for cancer screening and diagnosis. Here we report a protocol for Raman microspectroscopic analysis of different exfoliative cytology samples (cervical, oral and lung), covering sample preparation, spectral acquisition, preprocessing and data analysis. The protocol takes 2 h 20 min for sample preparation, measurement and data preprocessing and up to 8 h for a complete analysis. A key feature of the protocol is that it uses the same sample preparation procedure as commonly used in diagnostic cytology laboratories (i.e., liquid-based cytology …

Geocoding Cryptosporidiosis Cases In Ireland (2008–2017)—Development Of A Reliable, Reproducible, Multiphase Geocoding Methodology, Lisa Domegan, Patricia Garvey, Paul Mckeown, Howard Johnson, Paul Hynds, Jean O'Dwyer, Coilín Óhaiseadha

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Background: Geocoding (the process of converting a text address into spatial data) quality may affect geospatial epidemiological study findings. No national standards for best geocoding practice exist in Ireland. Irish postcodes (Eircodes) are not routinely recorded for infectious disease notifications and > 35% of dwellings have non-unique addresses. This may result in incomplete geocoding and introduce systematic errors into studies.

Aims: This study aimed to develop a reliable and reproducible methodology to geocode cryptosporidiosis notifications to fine-resolution spatial units (Census 2016 Small Areas), to enhance data validity and completeness, thus improving geospatial epidemiological studies.

Methods: A protocol was devised to utilise …

Cantilever-Based Sensor Utilizing A Diffractive Optical Element With High Sensitivity To Relative Humidity, Catherine M. Grogan, Faolan Radford Mcgovern, Rory Staines, George Amarandei, Izabela Naydenova

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High-sensitivity and simple, low-cost readout are desirable features for sensors independent of the application area. Micro-cantilever sensors use the deflection induced by the analyte presence to achieve high-sensitivity but possess complex electronic readouts. Current holographic sensors probe the analyte presence by measuring changes in their optical properties, have a simpler low-cost readout, but their sensitivity can be further improved. Here, the two working principles were combined to obtain a new hybrid sensor with enhanced sensitivity. The diffractive element, a holographically patterned thin photopolymer layer, was placed on a polymer (polydimethylsiloxane) layer forming a bi-layer macro-cantilever. The different responses of the …

Raman Spectroscopy Is Sensitive To Biochemical Changes Related To Various Cartilage Injuries, Rubina Shaikh, Ervin Nippolainen, Vesa Virtanen, Jari Torniainen, Lassi Rieppo, Simo Saarakkala, Isaac O. Afara, Juha Töyräs

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Raman spectroscopy is promising in vivo tool in various biomedical applications; moreover, in recent years, its use for characterizing articular cartilage degeneration has been developing. It has also shown potential for scoring the severity of cartilage lesions, which could be useful in determining the optimal treatment strategy during cartilage repair surgery. However, the effect of different cartilage injury types on Raman spectra is unknown. This study aims to investigate the potential of Raman spectroscopy for detecting changes in cartilage due to different injury types. Artificial injuries were induced in cartilage samples using established mechanical and enzymatic approaches to mimic trauma-induced …

An Assessment Of Contamination Fingerprinting Techniques For Determining The Impact Of Domestic Wastewater Treatment Systems On Private Well Supplies, Chris Fennell, Bruce Misstear, David O'Connell, Donata Dubber, Patrice Behan, Martin Danaher, Mary Moloney, Laurence Gill

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Private wells in Ireland and elsewhere have been shown to be prone to microbial contamination with the main suspected sources being practices associated with agriculture and domestic wastewater treatment systems (DWWTS). While the microbial quality of private well water is commonly assessed using faecal indicator bacteria, such as Escherichia coli, such organisms are not usually source-specific, and hence cannot definitively conclude the exact origin of the contamination. This research assessed a range of different chemical contamination fingerprinting techniques (ionic ratios, artificial sweeteners, caffeine, fluorescent whitening compounds, faecal sterol profiles and pharmaceuticals) as to their use to apportion contamination of private …