Digital Commons Network^™

The Quest For A Sustainable Future And The Dawn Of A New Journal At Michigan Law, David M. Uhlmann

Articles

When I joined the faculty of the University of Michigan Law School in 2007, the first assignment I gave students in my Environmental Law and Policy class was John McPhee's Encounters with the Archdruid. It must have seemed like a curious choice to them, particularly coming from a professor who just three months earlier had been the Chief of the Environmental Crimes Section at the U.S. Department of Justice. The book was not a dramatic tale of courtroom battles. In fact, the book was not even about the law, and the clash of environmental values it depicted pre-dated the environmental …

Apologies As Intellectual Property Remedies: Lessons From China, Xuan-Thao Nguyen

Articles

It is a frequent refrain that “the world is shrinking.” In this same vein, the global influence of China is clearly rising. Chinese businesses are becoming more prominent in the global market, and as such, the influence and effect of Chinese law is likewise gaining in import. Chinese intellectual property law is no different.

One notable aspect of Chinese intellectual property law is the availability of apology as a remedy. Despite a culture that places a high value on apology, and considerable legal scholarship and precedent regarding apology as remedy, many in the United States scoff at the notion of …

Feeling At Home: Learning, Law, Cognitive Science, And Narrative, Lea B. Vaughn

Articles

What is the "how and why" of law's affinity for narrative? In order to explain why the use of stories is such an effective teaching and presentation strategy in the law, this paper will consider theories and accounts from cognitive as well as evolutionary psychology, neuroscience, and, briefly, cultural anthropology. This account seeks to address "how" narrative helps us learn and use the law as well as "why" we are so compelled to use stories in teaching and in practice.

Brain science, simplified here, suggests that the first task is to grab someone's attention. Emotionally charged events are more likely …

A Call For Standards: An Overview Of The Current Status And Need For Guardian Standards Of Conduct And Codes Of Ethics, Karen E. Boxx, Terry W. Hammond

Articles

The role of trust in guardianships is rarely discussed, perhaps because of the assumption that court supervision of guardians reduces their power to act in any way other than trustworthy. However, as the number of persons needing guardianship protection increases while the resources available to courts to finance supervision decreases, the role of guardian is starting to become a more conventional fiduciary relationship complete with a hallmark downside-lack of supervision. Because of this trend, the concept of delineated standards for performance of a guardian's duties has taken on critical importance.

The 2001 Wingspan Conference, the second national conference on guardianship …

Comparison Of Micro- And Nanoscale Fe+3-Containing (Hematite) Particles For Their Toxicological Properties In Human Lung Cells In Vitro, Kunal Bhattacharya, Eik Hoffmann, Roel Schins, Jens Boertz, Eva-Maria Prantl, Gerrit Alink, Hugh Byrne, Thomas Kuhlbusch, Qamar Rahman, Hartmut Wiggers, Christof Schulz, Elke Dopp

Articles

The specific properties of nanoscale particles, large surface-to-mass ratio and highly reactive surfaces, have increased their commercial application in many fields. However, the same properties are also important for the interaction and bio-accumulation of the non-/biodegradable nanoscale particles in a biological system and are a cause for concern. Hematite (α-Fe2O3), being a mineral form of Fe(III) oxide, is one of the most used iron oxides besides magnetite. The aim of our study was the characterization and comparison of biophysical reactivity and toxicological effects of α-Fe2O3 nano- (d < 100 nm) and microscale (d < 5 μm) particles in human lung cells. Our study demonstrates that the surface reactivity of nanoscale α-Fe2O3 differs to that of microscale particles with respect to the state of agglomeration, radical formation potential, and cellular toxicity. The presence of proteins in culture medium and agglomeration were found to affect the catalytic properties of the hematite nano- and microscale particles. Both the nano- and microscale α-Fe2O3 particles were actively taken up by human lung cells in vitro, although, they were not found in the nuclei and mitochondria. …

Impaired Cleanance And Enhanced Pulmonary Inflammatory/Fibrotic Response To Carbon Nanotubes In Myeloperoxidase-Deficient Mice, Anna A. Shvedova, Alexandr A. Kapralov, Wei Hong Feng, Elena R. Kisin, Ashley R. Murray, Robert R. Mercer, Claudette M. St. Croix, Megan A. Lang, Simon C. Watkins, Nagarjun V. Konduru, Brett L. Allen, Jennifer Conroy, Gregg P. Kotchey, Bashir M. Mohamed, Aidan Meade, Yuri Volkov, Alexander Star, Bengt Fadeel, Valerian E. Kagan

Articles

Advancement of biomedical applications of carbonaceous nanomaterials is hampered by their biopersistence and pro-inflammatory action in vivo. Here, we used myeloperoxidase knockout B6.129X1-MPO (MPO k/o) mice and showed that oxidation and clearance of single walled carbon nanotubes (SWCNT) from the lungs of these animals after pharyngeal aspiration was markedly less effective whereas the inflammatory response was more robust than in wild-type C57Bl/6 mice. Our results provide direct evidence for the participation of MPO – one of the key-orchestrators of inflammatory response – in the in vivo pulmonary oxidative biodegradation of SWCNT and suggest new ways to control the biopersistence …

Effects Of Four Commercially Available Fxa Proteins On The Fluorogenic Anti-Fxa Assay When Monitoring Unfractionated Heparin, Vanessa Castro-Lopez, Brian Murray, Leanne F. Harris, James S. O'Donnell, Anthony J. Killard

Articles

Four commercially available Factor Xa (FXa) reagents were evaluated in a fluorogenic anti-FXa assay. The four reagents - of which three were of human origin and the fourth was bovine - were compared in terms of the resulting assay dynamic ranges, lag times, CV and R2 values, sum of squares as well as their sensitivity to unfractionated heparin (UFH) within the therapeutic range of 0-1.2 U mL-1. Based on a balance of performance characteristics, an optimum reagent was selected which had the best combination of all parameters. The best performing serine endopeptidase in the fluorogenic anti-FXa assay was found to …

Giving Voice To Rachel Carson: Putting Science Into Environmental Law, William H. Rodgers, Jr.

Articles

Certainly, the most pressing issue of modern times is to develop a body of environmental law (that includes climate change) that is highly responsive to science. Without demeaning the many distinctions between the exercise of science and the practice of law, let me cut to the chase and declare that science is mostly about the “pursuit of truth” and law is mostly about “who wins.” Anybody who doubts this proposition should examine the radical differences between the “Supreme Court of Science” in the United States and the Supreme Court of Law.

The Supreme Court of Science, the National Research Council, …

Shaken Baby Syndrome, Abusive Head Trauma, And Actual Innocence: Getting It Right, Keith A. Findley, Patrick D. Barnes, David A. Moran, Waney Squier

Articles

In the past decade, the existence of shaken baby syndrome (SBS) has been called into serious question by biomechanical studies, the medical and legal literature, and the media. As a result of these questions, SBS has been renamed abusive head trauma (AHT). This is, however, primarily a terminological shift: like SBS, AHT refers to the two-part hypothesis that one can reliably diagnose shaking or abuse from three internal findings (subdural hemorrhage, retinal hemorrhage, and encephalopathy) and that one can identify the perpetrator based on the onset of symptoms. Over the past decade, we have learned that this hypothesis fits poorly …

Work-Family Conflict And The Pipeline To Power: Lessons From European Gender Quotas, Julie C. Suk

Articles

The article examines the persistent gender disparities at the top of the legal profession, attributing them to work-family conflict and the disproportionate impact of caregiving responsibilities on women. It explores European gender quotas as a potential solution, arguing that such measures address the legitimacy and effectiveness of institutions by ensuring gender parity in leadership positions. While acknowledging the challenges in implementing quotas in the U.S., the analysis suggests that European approaches offer valuable insights for addressing the "leaky pipeline" and advancing gender equality in the legal profession.

The Moral Dimension Of Employment Dispute Resolution, Theodore J. St. Antoine

Articles

Dispute resolution may be viewed from the perspective of economics or negotiation or contract law or game theory or even military strategy. In this Article, I should like to consider employment dispute resolution in particular from the perspective of morality. I do not necessarily mean "morality" in any religious sense. By "morality" here I mean a concern about the inherent dignity and worth of every human being and the way each one should be treated by society. Some persons who best exemplify that attitude would style themselves secular humanists. Nonetheless, over the centuries religions across the globe have played a …

Support Of Non-Biological Children In Jewish Law, J. David Bleich

Articles

Adoption as a legal institution is unknown in Jewish law. Suppression of parental identity, as generally occurs in closed adoption, is banned “lest the earth become filled with licentiousness” (Leviticus 19:29). Rabbinic tradition interprets that verse as expressing concern regarding the possibility of a future incestuous marriage. Nevertheless, raising an orphan in one’s home is regarded as highly meritorious. However, binding obligations of support and maintenance can be undertaken only by means of contract. Such a contract in favor of a stepchild may be verbal if entered into at the time of marriage. Otherwise, a formal kinyan, i.e., one of …

Wisdom Of The Ages Or Dead-Hand Control? Patentable Subject Matter For Diagnostic Methods After In Re Bilski, Rebecca S. Eisenberg

Articles

In 1980, the Supreme Court gave a reassuring signal to the then-nascent biotechnology industry about the availability of patent protection for the fruits of its research when it upheld the patentability of a genetically modified living organism in Diamond v. Chakrabarty. Twenty-five years later, the Court seemed poised to reexamine the limits of patentable subject matter for advances in the life sciences when it granted certiorari in Laboratory Corporation v. Metabolite. But the Federal Circuit had not addressed the patentable subject matter issue in Laboratory Corporation, and the Court ultimately dismissed the certiorari p etition as improvidently granted. Five years …

Assessment Of Morphological Variation In Irish Brassica Oleracea Species, Mohamed El-Esawi, Paula Bourke, Kieran Germaine, Renee Malone

Articles

This study aimed at assessing the morphological variation in 25 accessions of an Irish collection of Brassica oleracea using 44 morphological traits. The morphological traits showed a pronounced variation among accessions. Vegetative preflowering and maturity traits revealed higher variation than seedling traits. Of the 44 morphological descriptors used, 28 were significantly different and proved useful in examining diversity and differentiating among accessions studied. Principal component analysis (PCA) showed variation among accessions, where 87.24% of the total variation in the morphological data was separated on the first five components, indicating a high degree of correlation among traits studied. Cluster analysis grouped …

The Biodiversity Of Thermoduric Bacteria Isolated From Whey, Joseph Meade, Seamus Fanning, Kevinia Mcgill, Ciara Walsh

Articles

Thermoduric gram-positive bacteria are indigenous in milk, cheese, whey and other dairy products. They are capable of surviving heat processes and can result in quality defects and a shortened product shelf life. In Ireland, premium products such as whey protein concentrate (WPC) are often adversely affected by these microorganisms, particularly during the winter months.A high bacterial count in the WPC can result in the product being sold at a lower grade, with an overall loss of revenue for the manufacturer. This study recovered thermoduric bacterial isolates (n = 140) from an Irish WPC process during the months of November–February.Using molecular …

Antimicrobial, Antioxidant And Free Radical-Scavenging Capacity Of Brown Seaweed Himanthalia Elongata From Western Coast Of Ireland, Gaurav Rajauria, Amit Jaiswal, Nissreen Abu-Ghannam, Shilpi Gupta

Articles

Water,methanol and mixtures (20–80%) thereof have been used for the extraction of phenolic compounds from Irish brown seaweed Himanthalia elongata for studying its antimicrobial and antioxidant properties.The 60%methanolic extract exhibited significantly (P < 0.05) the highest value of yield (6.8 6 0.24%), total phenol (286.0 6 4.61 mg gallic acid equivalents/g), flavonoid (109.8 6 2.68 mg quercetin equivalents/g) and condensed tannin content (35.6 6 1.03 mgcatechin equivalents/ g). Antimicrobial activity of 60% methanolic extract tested from disc diffusion and broth dilution methods was effective against various food spoilage and pathogenic bacteria studied.The same extract exhibited statistically highest reducing power and antioxidant capacity againstDPPHradical,metal ions, lipid peroxides and hydrogen peroxide radicals. The UV-visible spectroscopy showed absorption maxima at 205 and 260 nm and the presence of hydroxyl group (3,431 cm-1) and an aromatic ring (around 1,465, 1,505 and 1,624 cm-1) in Fourier Transform Infrared spectroscopy, suggested the presence of phenolic compounds in the extract.

The Impact Of Delactosed Whey Permeat Treatment On Shelf-Life And Antioxidant Contents Of Strawberries, Catherine Barry-Ryan, Lubna Ahmed, Ana Belen Martin-Diana, Daniel. Rico

Articles

The aim of this study was to investigate the effect of delactosed whey permeate (DWP) 27 treatment on antioxidant and physico-chemical properties of strawberries. Fresh strawberries 28 treated with 3 % DWP were analyzed for different quality, nutritional and microbiological 29 markers during 10 days of storage at 5 °C. The results showed that DWP treatment 30 significantly reduced incidences of decay (70 %) and numbers of total aerobic counts (~1.4 31 Log10 CFU/g) and yeast and moulds (~1.8 Log10 CFU/g). DWP treatment also inhibited the 32 loss of firmness (15 %) and maintained significantly (p

A Laboratory Inter-Comparison Of The Importance Of Serum Serotonin Levels In The Measurement Of A Range Of Radiation-Induced Bystander Effects: Overview Of Study And Results Presentation., Fiona Lyng, C. Mothersill, F. Antonelli, V. Dini, M. Kämäräinen,, B. Schilling-Tóth

Articles

No abstract provided.

Should Any Workplace Be Exempt From Smoke-Free Law: The Irish Experience, M. Mccaffrey, Patrick J. Goodman, A. Gavigan, C. Kenny, C. Hogg, L. Byrne, J. Mcloughlin, Luke Clancy

Articles

Background.

In 2004, the Irish Government introduced national legislation banning smoking in workplaces; with exemptions for “a place of residence”. This paper summarises three Irish studies of exempted premises; prisons, psychiatric hospitals and nursing homes. Methods. PM2.5 and nicotine were measured in nursing homes and psychiatric hospitals, in addition to ultrafine particles in the hospitals. In the prisons, officers (n = 30) completed exhaled breath Carbon Monoxide (CO) measurements. Questionnaires determined officers’ opinion on introducing smoking prohibitions in prisons. Nursing home smoking policies were examined and questionnaires completed by staff regarding workplace secondhand smoke (SHS) exposure. Findings. Ultrafine particle concentrations …

The Effects Of Fatty Desposits On The Accuracy Of The Fibroscan Liver Transient Elastography Ultrasound System, S. Cournane, Jacinta Browne, Andrew Fagan

Articles

A new generation of ultrasound transient elastography (TE) systems have emerged which exploit the well-known correlation between the liver’s pathological and mechanical properties through measurements of the Young’s elastic modulus; however, little work has been carried out to examine the effect that fatty deposits may have on the TE measurement accuracy. An investigation was carried out on the effects on the measurement accuracy of a transient elastography ultrasound system, the Fibroscan®, caused by overlaying fat layers of varying thickness on healthy liver-mimicking phantoms, simulating in vivo conditions for obese patients. Furthermore, a steatosis effect similar to that in non-alcoholic fatty …

The Emerging Role Of Acyl-Coa Thioesterases And Acyltransferases In Regulating Peroxisomal Lipid Metabolism, Mary Hunt, Marina Siponen, Stefan Alexson

Articles

The importance of peroxisomes in lipid metabolism is now well established and peroxisomes contain approximately 60 enzymes involved in these lipid metabolic pathways. Several acyl-CoA thioesterase enzymes (ACOTs) have been identified in peroxisomes that catalyze the hydrolysis of acyl-CoAs (short-, medium-, long- and very long-chain), bile acid-CoAs, and methyl branched-CoAs, to the free fatty acid and coenzyme A. A number of acyltransferase enzymes, which are structurally and functionally related to ACOTs, have also been identified in peroxisomes, which conjugate (or amidate) bile acid-CoAs and acyl-CoAs to amino acids, resulting in the production of amidated bile acids and fatty acids. The …

Analysis Of Human Skin Tissue By Raman Microspectroscopy: Dealing With The Background, Franck Bonnier, Syed Mehmood Ali, Peter Knief, Helen Lambkin, Kathleen Flynn, Vincent Mcdonagh, Claragh Healy, Thomas Lee, Fiona Lyng, Hugh Byrne

Articles

Raman microspectroscopy is widely used for molecular characterisation of tissue samples. Nevertheless, when working in vitro on tissue sections, the presence of a broad background to the spectra remains problematic and its removal requires advanced methods for pre-processing of the data. To date, research efforts have been primarily devoted to development of techniques of statistical analysis to extract the relevant information contained in the spectra. However, few attempts have been made to understand the origin of the background and to improve the protocols used for the collection of Raman spectra that could lead to the reduction or elimination of the …

Statistical Optimization Of Blanching Time And Temperature Of Irish York Cabbage Using Desirability Function, Amit Jaiswal, Nissreen Abu-Ghannam, Shilpi Gupta

Articles

The effect of different heat treatments, as a means of preprocessing, on the phytochemicals present in Irish York cabbage was studied. A comparison of blanching (by immersing in water) and microwaving (using water as a medium) indicated that microwaving is detrimental to the phytochemicals present in cabbage. To achieve a blanching time and temperature combination that would result in minimal loss of phytochemicals, central composite design that integrates a desirability approach was used. A second-order polynomial equation was developed, indicating the effect of the blanching time and temperature on the total phenol content (TPC), total flavonoid content (TFC) and 2,2-diphenyl-1-picrylhydrazyl …

When Is A Difference Really Different? Learners' Discrimination Of Linguistic Contrasts In American Sign Language, Joseph Bochner, Karen Christie, Peter Hauser

Articles

Learners’ ability to recognize linguistic contrasts in American Sign Language (ASL)was investigated using a paired-comparison discrimination task. Minimal pairs containing contrasts in five linguistic categories (i.e., the formational parameters of movement, handshape, orientation, and location in ASL phonology, and a category comprised of contrasts in complex morphology) were presented in sentence contexts to a sample of 127 hearing learners at beginning and intermediate levels of proficiency and 10 Deaf native signers. Participants’ responses were analyzed to determine the relative difficulty of the linguistic categories and the effect of proficiency level on performance. The results indicated that movement contrasts were the …

Location Effect On Heritability Estimates Of Yield Traits In Mungbean Derived From F2 Populations, Hidayat Ullah, Iftikhar Hussain Khalil, Ltafullah, Hayat Badshah, Durre Shahwar, David A. Lightfoot

Articles

Heritability and genetic advance were estimated in four F₂ mungbean populations (Ramzan×ML-5, NM- 92×NM-1919, NM-1919×ML-5 and ML-5×NM-51) at two locations (Peshawar and Swat) of Khyber Pakhtunkhwa province, Pakistan, during 2008. Combined analysis exhibited highly significant differences among the genotypes and locations for pods plant^-1, pod length, seeds pod^-1, 1000-seed weight and seed yield. Similarly, genotype-by-location interaction was highly significant for pods plant^-1 and 1000-seed weight. Averaged over five parents and four F₂ populations, means for clusters plant^-1, pods plant^-1, pod length, seeds pod^-1, 1000-seed weight and seed …

Sex, Privacy And Public Health In A Casual Encounters Culture, Mary D. Fan

Articles

The regulation of sex and disease is a cultural and political flashpoint and recurring challenge that law's antiquated arsenal has been hard- pressed to effectively address. Compelling data demonstrate the need for attention—for example, one in four women aged fourteen to nineteen is infected with at least one sexually transmitted disease ("STD"); managing STDs costs an estimated $15.9 billion annually; and syphilis, once near eradication, is on the rise again, as are the rates of HIV diagnosis among people aged fifteen to twenty-four. Public health officials on the front lines have called for paradigm changes to tackle the enormous challenge. …

Performance Of Coiled Tube Ultraviolet Reactors To Inactivate Escherichia Coli W1485 And Bacillus Cereus Endospores In Raw Cow Milk And Commercially Processed Skimmed Cow Milk, Ruplal Choudhary, Srinivasaro Bandla, Dennis G. Watson, John Haddock, Amer Abughazaleh, Bhaskar Battacharya

Articles

Two coiled tube reactors were designed to investigate the influence of Reynolds number (Re) and diameter of fluid carrying tube on UV-C inactivation of Escherichia coli W1485 and Bacillus cereus endospores in raw cow milk (RCM) and skimmed cow milk (SCM) at room temperature. UV reactors were constructed using perfluoroalkoxy (PFA) tubing having internal diameters of 1.6 and 3.2 mm and each had a residence time of 11.3 s. Four levels of Re were tested for each milk type, each tube size and each bacteria type. Inactivation efficiency increased as the Re increased in both the reactors for both types …

Understanding The Molecular Information Contained In Principal Component Analysis Of Vibrational Spectra Of Biological Systems, Franck Bonnier, Hugh Byrne

Articles

K-means clustering followed by Principal Component Analysis (PCA) is employed to analyse Raman spectroscopic maps of single biological cells. K-means clustering successfully identifies regions of cellular cytoplasm, nucleus and nucleoli, but the mean spectra do not differentiate their biochemical composition. The loadings of the principal components identified by PCA shed further light on the spectral basis for differentiation but they are complex and, as the number of spectra per cluster is imbalanced, particularly in the case of the nucleoli, the loadings under-represent the basis for differentiation of some cellular regions. Analysis of pure bio-molecules, both structurally and spectrally distinct, in …

Climate Change And The Conservation Of Archaeological Sites: A Review Of Impacts Theory, Caithleen Daly

Articles

This article identifies the current state of knowledge in the literature regarding the possible impacts of future climatic change on archaeological sites and ensembles. Drawing on the literature review a matrix of potential impacts is collated to provide a simplified overview. This theoretical ‘menu’ is then tested by applying it to a vulnerability assessment of the World Heritage site of Skellig Michael in Ireland. The case study results reveal some knowledge gaps, particularly in regard to the impacts of climate change on buried archaeological remains.

Phenomenological Study Of Postgraduate Researchers' Experiences Of Nanoscience And Nanotechnology Research, Deepa Chari, Paul Irving, Robert Howard, Brian Bowe

Articles

Over the past few decades, scientific disciplines have changed significantly with the introduction of new and complex aspects of interdisciplinary research, particularly in the area of nanoscience and nanotechnology (N&N). The current attempts to develop science education programmes in N&N area to adopt these complex changes however are mainly focussed towards the core scientific knowledge, and, not much attention has been paid to identify the attributes knowledge, skills and competences necessary to successfully undertake N&N research. Identification of these attributes is important so that the core scientific knowledge can be embedded in the curricula more effectively. Also, to work successfully …