Digital Commons Network^™

Structural Dependence Of The In Vitro Cytotoxicity, Oxidative Stress And Uptake Mechanisms Of Poly(Propylene Imine) Dendritic Nanoparticles, Humza Khalid, Sourav Prasanna Mukherjee, Luke O'Neill, Hugh Byrne

Articles

The in vitro cytotoxic and intracellular oxidative stress responses to exposure to poly (propylene imine) (PPI) dendritic nanoparticles of increasing generation (number of repeated branching cycles) (G0-G4) were assessed in an immortal non-cancerous human keratinocyte cell-line (HaCaT). Confocal fluorescence microscopy with organelle staining was used to explore the uptake and intracellular trafficking mechanisms. A generation and dose dependent cytotoxic response was observed, increasing according to generation and therefore number of surface amino groups. A comparison of the cytotoxic response of G4 PPI and the related G4 Poly (amido amine) dendrimer indicates that the PPI with the same number of surface …

Quality Markers Of Functional Tomato Juice With Added Apple Phenolic Antioxidants, Laura Massini, Daniel Rico, Ana Belen Martin-Diana, Catherine Barry-Ryan

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The natural approach to food stabilisation is at the forefront of research on plant compounds for food use. Matrix interactions and stability studies of the incorporated foods are necessary prior to further food processing. In this study, apple peel phenolic fractionated based on acidity (flavonoids and phenolic acids) were added to a commercial bottled tomato juice. The juice was left open i.e. air in the headspace at 4°C for 4 days to assess its physical-chemical quality, and for 10 days for the microbiological analysis. Quality markers were analysed (colour and turbidity) and showed that apple peel phenolics, particularly procyanidins, could …

Wellness International Network V. Sharif: Minimizing The Jurisdictional Impact Of Stern Through Consent Of Bankruptcy Litigants, Ishaq Kundawala

Articles

Without conducting an official poll, it can safely be said that a majority of lawyers, judges, and scholars agree the nature and scope of bankruptcy jurisdiction is quite confusing and at times uncertain. There has always been—and perhaps always will be—a tug-of-war between the legislative and judicial branches of government over the proper scope of bankruptcy jurisdiction, with one side expanding the reach of bankruptcy jurisdiction legislatively and the other side limiting that reach judicially. This poses a classic separation of powers struggle between the two branches, which has certainly played out in recent bankruptcy jurisprudence.

When Congress created the …

Iron Acquisition In The Cystic Fibrosis Lung And Potential For Novel Therapeutic Strategies, Jean Tyrrell, Máire Callaghan

Articles

Iron acquisition is vital to microbial survival and is implicated in the virulence of many of the pathogens that reside in the cystic fibrosis (CF) lung. The multifaceted nature of iron acquisition by both bacterial and fungal pathogens encompasses a range of conserved and species-specific mechanisms, including secretion of iron-binding siderophores, utilization of siderophores from other species, release of iron from host iron-binding proteins and haemoproteins, and ferrous iron uptake. Pathogens adapt and deploy specific systems depending on iron availability, bioavailability of the iron pool, stage of infection and presence of competing pathogens. Understanding the dynamics of pathogen iron acquisition …

Yo-Yo Intermittent Recovery Test Performance In Subelite Gaelic Football Players From Under Thirteen To Senior Age Groups, Mark Roe, Shane Malone

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Gaelic football is indigenous to Ireland and has similar locomotion profiles to soccer and Australian Football. Given the increasing attention on long-term player development, investigations into age-related variation in Yo-YoIR1 performance may provide useful information in talent identification, programme design, and player monitoring. Therefore, the aim of this study was to evaluate Yo-YoIR1 performance across Gaelic football age groups. Male participants (n = 355) were recruited from division one, Gaelic football teams. Participants were allocated to one of seven groups according to respective age groups from under 13 (U13), under 14, under 15 (U15), under 16 (U16), minor, under 21 …

Biofilm Growth Kinetics And Nutrient (N/P) Adsorption In An Urban Lake Using Reclaimed Water: A Quantitative Baseline For Ecological Health Assessment, Tianzhi Wang, Zhenci Wu, Yunkai Li, Mingchao Liang, Zhenhua Wang, Paul Hynds

Articles

Reclaimed wastewater reuse represents an effective method for partial resolution of increasing urban water shortages; however, reclaimed water may be characterized by significant contaminant loading, potentially affecting receiving ecosystem (and potentially human) health. The current study examined biofilm growth and nutrient adsorption in Olympic Lake (Beijing), the largest artificial urban lake in the world supplied exclusively by reclaimed wastewater. Findings indicate that solid particulate, extracellular polymeric substance (EPS) and metal oxide (Al, Fe, Mn) constituent masses adhere to a bacterial growth curve during biofilm formation and growth. Peak values were observed after ≈30 days, arrived at dynamic stability after ≈50days …

Biofilm Microbial Community Structure In An Urban Lake Utilizing Reclaimed Water, Tianzhi Wang, Yunkai Li, Tingwu Xu, Naiyang Wu, Mingchao Liang, Paul Hynds

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Analyses of biofilm community structure may potentially be employed for aquatic ecosystem health assessment, however, to date, biofilm diversity within urban lakes using reclaimed water has not been examined. Accordingly, the microbial community diversity and structure of biofilms from the surface of multiple matrices with varying roughness (0.1, 1.0 and 10.0 μm) were characterized using a suite of molecular techniques including scanning electron microscopy, genetic fingerprinting and phospholipid-derived fatty acid analyses. Samples were largely comprised of inorganic particles, algae and numerous bacterial species; 12 phospholipid-derived fatty acid (PLFA) types were identified, significantly less than typically associated with sewage. Both growth …

Campus Sexual Assault Adjudication: Why Universities Should Reject The Dear Colleague Letter, Tamara Rice Lave

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No abstract provided.

Physical And Oxidative Stability Of Functional Olive Oil-In-Water Emulsions Formulated Using Olive Mill Wastewater And Whey Proteins, Nicola Caporaso, Alessandro Genovese, Roisin Burke, Catherine Barry-Ryan, Raffaele Sacchi

Articles

The present paper reports on the use of phenolic extracts from olive mill wastewater (OMW) in model olive oil-in-water (O/W) emulsions to study their effect on their physical and chemical stability. Spray-dried OMW polyphenols were added to a model 20% olive O/W emulsion stabilized with whey protein isolate (WPI) and xanthan gum, in phosphate buffer solution at pH 7. The emulsions were characterised under accelerated storage conditions (40 °C) up to 30 days. Physical stability was evaluated by analysing the creaming rate, mean particle size distribution and mean droplet size, viscosity and rheological properties, while chemical stability was assessed through …

Effect Of Olive Mill Wastewater Phenolic Extract, Whey Protein Isolate And Xanthan Gum On The Behaviour Of Olive O/W Emulsions Using Response Surface Methodology., Nicola Caporaso, Alessandro Genovese, Roisin Burke, Catherine Barry-Ryan, Raffaele Sacchi

Articles

Spray-dried polyphenols extracted from olive mill wastewater (OMW) were used to formulate 20% olive oil-in-water (O/W) emulsions stabilised with whey protein isolate (WPI) and xanthan gum at pH 7. The effects of olive biophenol extract (0.9-4.4 mM), whey protein isolate (0.13-0.5 %) and xanthan gum (0.06-0.2 %) on the physical stability (creaming index), viscosity, emulsion droplet size and distribution, primary and secondary oxidation products were assessed over accelerated storage of emulsions. Response surface methodology (RSM) was applied for experimental design using three-factor central composite design (CCD) with 3 central points. The effects of OMW phenolics, WPI and xanthan gum were …

The Running Performance And Estimated Energy Cost Of Hurling Specific Small-Sided Games, Shane Malone, Kieran Collins, Dominic Doran

Articles

The current study examined the extent to which pitch dimensions can influence the physical and estimated energetic demands of hurling small-sided games. Training data (n = 990) were collected from 24 (age 25.5 ± 3.2 years; height 178.9 ± 3.2 cm; body mass 78.5 ± 4.5 kg) hurling players using 4-Hz global positioning system technology (VX Sport, Lower Hutt, New Zealand). Total distance (m), high-speed running distance (m; ≥ 17 km/h), very high-speed running distance (m; ≥ 22 km/h), total accelerations (n), acceleration distance (m), peak and mean velocity (km/h) were considered. In addition changes in velocity …

Effects Of Various Concentrations Of Carbohydrate Mouth Rinse On Cycling Performance In A Fed State, Simon Devenney, Kieran Collins, Marcus Shortall

Articles

The objective of this study was to identify the effects of mouth rinsing with a 6% and 16% carbohydrate solution (CHO) on time trial performance when compared to a 0% control (PLA) when in a fed state. Twelve recreationally active males underwent three trials by which they had to complete a set workload (600 ± 65 W) in a fed state. Throughout each trial, participants rinsed their mouths with a 25 ml bolus of a 0% PLA, 6% or 16% CHO (maltodextrin) for every 12.5% of work completed. Rating of perceived exertion (RPE) and heart rate were recorded every 12.5% …

Can Sport Be ‘Un-Political’?, Ansgar Thiel, Anna Vilanova, Martin Toms, Lone Friis Thing, Paddy Dolan

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Sports officials often claim that sport has to be ‘un-political’. This argument is most notably made in two contexts: Firstly, when the decision of awarding Olympic Games or World Championships to nations that struggle with human right issues is justified by the IOC or other international sporting federations. Secondly, when athletes express their concern over social injustices with symbolic gestures of protest in sports-specific contexts.

Anti-Incarcerative Remedies For Illegal Conditions Of Confinement, Margo Schlanger

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Opposition to mass incarceration has entered the mainstream. But except in a few states, mass decarceration has not, so far, followed: By the end of 2014 (the last data available), nationwide prison population had shrunk only 3% off its (2009) peak. Jail population, similarly, was down just 5% from its (2008) peak. All told, our current incarceration rate - 7 per 1,000 population - is the same as in 2002, and four times the level in 1970, when American incarceration rates began their rise. Our bloated prisoner population includes many groups of prisoners who are especially likely to face grievous …

Evaluation Of Plasma, High-Pressure And Ultrasound Processing On The Stability Of Fructooligosaccharides, Elenilson Alves Filho, Patrick J. Cullen, Jesus Maria Frias, Paula Bourke, Brijesh Tiwari, Edy Brito, Sueli Rodrigues, Fabiano Fernandes

Articles

Fructooligosaccharides (FOS) are among the main carbohydrates with prebiotic activity, and they are the most applied functional carbohydrate ingredient in the food industry. FOS are known to hydrolyse when subjected to thermal processing, thus partially losing its functional properties. In this study, we evaluate whether three nonthermal technologies are suitable for processing FOS regarding its stability after processing. FOS were subjected to ultrasound, high-pressure processing (HPP) and atmospheric cold plasma (ACP). The FOS solution, 70 g L−1, was set at a concentration recommended for human intake. The treatments were carried out at operating conditions usually used for microbial inactivation in …

Reentering Survivors: Invisible At The Intersection Of The Criminal Legal System And The Domestic Violence Movement, Courtney K. Cross

Articles

Like all returning citizens, women coming home after incarceration face significant challenges to successful reentry. In addition to the collateral consequences of their criminal convictions, reentering women also encounter uniquely gendered obstacles. This Article explores one such obstacle: the relationship between women's reentry and domestic violence. Women on probation or parole who are also experiencing domestic violence too often fall into a blind spot in which the structure of community supervision pressures them to remain in unsafe homes and also punishes them when the abuse they endure interferes with their ability to comply with the conditions of their release. Because …

The Tribes Of Maycomb County: The Continuing Quest To Transcend Our Differences, Steven H. Hobbs

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No abstract provided.

Fructose Acute Effects On Glucose, Insulin, And Triglyceride After A Solid Meal Compared With Sucralose And Sucrose In A Randomized Crossover Study, Clare Gallagher, J.B. Keogh, Eva Pedersen, Peter M. Clifton

Articles

Fructose, which is a sweetener with a low glycemic index, has been shown to elevate postprandial triglyceride compared with glucose. There are limited data on the effect of fructose in a solid mixed meal containing starch and protein.We determined the effects of sucrose, fructose, and sucralose on triglyceride, glucose, and insulin in an acute study in healthy, overweight, and obese individuals.The study had a randomized crossover design. Twenty-seven participants with a mean age of 44 y and a mean body mass index (in kg/m(2)) of 26 completed the study. Fructose (52 g), sucrose (65 g), and sucralose (0.1 g) were …

Views Of Fathers In Ireland On The Experience And Challenges Of Having A Breast-Feeding Partner, Annemarie Bennett, Daniel Mccartney, John Kearney

Articles

Objective this study investigated the relationship between fathers and breast feeding in Ireland.

Design and method a cross-sectional semi-quantitative questionnaire with closed-ended and open-ended questions was posted to 1398 men with an Irish partner who had given birth 4–7 months previously. Fathers who specified that their partner breast fed their last or only child were questioned about their: influence on the breast feeding decision; ability to assist with breast feeding challenges; preferred type of information on breast feeding; perceived advantages and disadvantages to breast feeding; and views on breastfeeding in public. Data from closed-ended questions on breast feeding were presented …

Relationship Between Fasting Plasma Glucose Levels And Maternal Food Group And Macronutrient Intakes In Pregnancy, Laura Mullaney, Aisling Brennan, Shona Cawley, Amy C. O'Higgins, Daniel Mccartney, Michael J. Turner

Articles

Aim Increased maternal body mass index (BMI) has been consistently associated with elevated blood glucose levels during pregnancy. Studies to date investigating the relationship between maternal blood glucose levels and dietary intake have shown mixed results. We investigated the association between maternal fasting plasma glucose (FPG) levels and food group and macronutrient intakes in the first trimester of pregnancy, after adjustment for maternal bodyweight.

Methods Women were recruited after sonographic confirmation of an ongoing singleton pregnancy in the first trimester. Dietary information was collected using the validated Willett Food Frequency Questionnaire. Maternal height and weight were measured and BMI calculated. …

Parallel Profiles Of Inflammatory And Effector Memory T Cells In Visceral Fat And Liver Of Obesity-Associated Cancer Patients, Melissa Conroy, Karen Galvin, Suzanne Doyle, Maria Kavanagh, Ann-Marie Mongan, Aoife Cannon, Gillian Moore, John Reynolds, Joanne Lysaght

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In the midst of a worsening obesity epidemic, the incidence of obesity-associated morbidities, including cancer, diabetes, cardiac and liver disease is increasing. Insights into mechanisms underlying pathological obesity-associated inflammation are lacking. Both the omentum, the principal component of visceral fat, and liver of obese individuals are sites of excessive inflammation, but to date the T cell profiles of both compartments have not been assessed or compared in a patient cohort with obesity-associated disease. We have previously identified that omentum is enriched with inflammatory cytokines, chemokines and T cells. Here, we compared the inflammatory profile of T cells in the omentum …

Use Of A Web-Based Dietary Assessment Tool In Early Pregnancy, Laura Mullaney, Amy C. O'Higgins, Shona Cawley, R. Kennedy, Daniel Mccartney, M.J. Turner

Articles

Background Maternal diet is critical to fetal development and lifelong health outcomes. In this context, dietary quality indices in pregnancy should be explicitly underpinned by data correlating food intake patterns with nutrient intakes known to be important for gestation.

Aims Our aim was to assess the correlation between dietary quality scores derived from a novel online dietary assessment tool (DAT) and nutrient intake data derived from the previously validated Willett Food Frequency Questionnaire (WFFQ).

Methods 524 women completed the validated semiquantitive WFFQ and online DAT questionnaire in their first trimester. Spearman correlation and Kruskal–Wallis tests were used to test associations …

Potassium Intake, Bioavailability, Hypertension, And Glucose Control, Michael S. Stone, Lisa Martyn, Connie M. Weaver

Articles

Potassium is an essential nutrient. It is the most abundant cation in intracellular fluid where it plays a key role in maintaining cell function. The gradient of potassium across the cell membrane determines cellular membrane potential, which is maintained in large part by the ubiquitous ion channel the sodium-potassium (Na+-K+) ATPase pump. Approximately 90% of potassium consumed (60-100 mEq) is lost in the urine, with the other 10% excreted in the stool, and a very small amount lost in sweat. Little is known about the bioavailability of potassium, especially from dietary sources. Less is understood on how bioavailability may affect …

An Analysis Of Folic Acid Supplementation In Women Presenting For Antenatal Care, Shona Cawley, Laura Mullaney, Aoife Mckeating, Maria Farren, Daniel Mccartney, Michael Turner

Articles

Background: Neural tube defects (NTDs) are major congenital malformations that are potentially preventable if the woman takes periconceptional folic acid (FA) supplements. A recent report found that NTD incidence had increased in Ireland. This study examined the usage of FA supplementation in women presenting for antenatal care in a maternity hospital.

Controlling Microbial Safety Challenges Of Meat Using High Voltage Atmospheric Cold Plasma, Lu Han, Dana Ziuzina, Caitlin Marie Heslin, Daniela Boehm, Apurva Patange, David Millan-Sango, Vasilis Valdramidis, Patrick J. Cullen, Paula Bourke

Articles

Atmospheric cold plasma (ACP) is a non-thermal technology, effective against a wide range of pathogenic microorganisms. Inactivation efficacy results from plasma generated reactive species. These may interact with any organic components in a test matrix including the target microorganism, thus food components may exert a protective effect against the antimicrobial mode of action. The effect of an in-package high voltage ACP process applied in conjunction with common meat processing MAP gas compositions as well as bacteria type and meat model media composition have been investigated to determine the applicability of this technology for decontamination of safety challenges associated with meat …

Resolving The Policy Paradox: The Case Of Biofuel Production In Ireland, Alan Gilmer, Mark J. Mcgarrity, Vivienne Byers

Articles

Purpose – The purpose of this paper is to determine the status of policy design and policy implementation in the biofuel sector in Ireland. The focus of the work addresses the overarching operational context of the biofuel sector in Ireland and the role of different actors in shaping and resolving inconsistencies in policy outlook and practice. Design/methodology/approach – This study used a qualitative research approach involving a series of semi-structured interviews with members of the relevant sub-groups concerned. This study sought to address two questions – whether current or proposed policy is likely to affect consumption of indigenous biofuel feedstocks …

Fatigue Modeling Via Mammalian Auditory System For Prediction Of Noise Induced Hearing Loss, Pengfei Sun, Jun Qin, Kathleen Campbell

Articles

Noise induced hearing loss (NIHL) remains as a severe health problem worldwide. Existing noise metrics and modeling for evaluation of NIHL are limited on prediction of gradually developing NIHL (GDHL) caused by high-level occupational noise. In this study, we proposed two auditory fatigue based models, including equal velocity level (EVL) and complex velocity level (CVL), which combine the high-cycle fatigue theory with the mammalian auditory model, to predict GDHL. The mammalian auditory model is introduced by combining the transfer function of the external-middle ear and the triple-path nonlinear (TRNL) filter to obtain velocities of basilar membrane (BM) in cochlea. The …

New Theory Proven Of Disease And New Ideas And New Methods For Medical Science For Vaccinations, Cures And Treatments Of Diseases, Stephen Smith

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Abstract This research paper for medical science is applying new original further science aimed at curing the Ebola virus and adding to research for the vaccination, curing and treatment of diseases. This research approach achieves the construction of own research from accumulating answers to set goals finding answers to analysis of information of factors associated to disease research and this research adds to medical development needs as observed by actions reported from sources in the news media and from sources in general medical science literature. New theories are presented that apply to medical science involving disease function, new case types, …

Applications And Comparison Of Continuous Wavelets Transforms On Analysis Of A-Wave Impulse Noise, Jun Qin, Pengfei Sun

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Noise induced hearing loss (NIHL) is a serious occupational related health problem worldwide. The A-wave impulse noise could cause severe hearing loss, and characteristics of such kind of impulse noise in the joint time-frequency (T-F) domain are critical for evaluation of auditory hazard level. This study focuses on the analysis of A-wave impulse noise in the T-F domain using continual wavelet transforms. Three different wavelets, referring to Morlet, Mexican hat, and Meyer wavelets, were investigated and compared based on theoretical analysis and applications to experimental generated A-wave impulse noise signals. The underlying theory of continuous wavelet transform was given and …

Student Educational Background, Perceptions And Expectations Towards Optometry: An Emerging Eye Health Profession Mozambique., James Loughman, Ving Fai Chan, Vanessa Raquel Moodley, Luigi Bilotto, Kovin Naidoo

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Background: The University of Lurio, School of Optometry in Mozambique is a new program in Africa. The school, the first to serve Portuguese-speaking Africa, can act as a template for such initiatives in other African countries and other limited-resource settings around the world. A major challenge facing such programs is the lack of knowledge about the profession, which impacts the recruitment of students and their expectations of the program. This study was conducted to understand students’ pre-enrollment educational background, perceptions and career expectations as an optometrist in Mozambique so as to inform future enrollment and other similar initiatives. Methods: First-year …