Digital Commons Network^™

Advisors Or Enablers? Bringing Professional Service Providers Into The Guiding Principles’ Fold, Anita Ramasastry

Articles

After a decade, different businesses adhere to the UN Guiding Principles on Business and Human Rights (UNGPs). Some key commercial entities, however, remain largely outside of the UNGPs universe, including professional service providers (PSPs) who are retained by businesses to provide  expert advice and services. These advisors include lawyers, management consultants, architects and others. Some may have specialized units that provide advice on the UNGPs when retained solely for that purpose. But when asked to provide general commercial legal advice, to design a building, or restructure a business, such advisors do not typically appear to apply the UNGPs, to identify …

Visualizing The Impact Of Europe’S Slow Covid-19 Vaccine Rollout, Mathias Beck, Gail Sheppard

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On 31 March 2021, the WHO Regional Office for Europe issued a formal statement of concern regarding the slow vaccine rollout across Europe [1]. The WHO noted that the “Region remains the second most affected by SARS-CoV-2 of all the world’s regions” which was worrying, especially because the more transmissible B.1.1.7 was now dominant in the region [1]. It further contrasted this with the experiences of the UK, by noting that according to data from Public Health England, “COVID-19 vaccines have saved, at the very least, over 6,000 lives among people over 70 since vaccination started in December 2020”. Beyond …

Label-Free Screening Of Biochemical Changes In Macrophage-Like Cells Following Mos2 Exposure Using Raman Micro-Spectroscopy, Caroline Moore, Andrew Harvety, Jonathan N. Coleman, Hugh Byrne, Jennifer Mcintyre

Articles

The emergence of large scale production techniques for 2D particulate materials has dramatically increased their applications potential. Understanding the interactions of biological cells with such particulate material is therefore of paramount importance, both for toxicological assessment and potential biomedical applications. Conventional in-vitro cytological assays commonly record only a single colorimetric end-point, and do not provide an in-depth analysis of how such materials are uptaken and processed within cells. To demonstrate its potential as an alternative, label free approach, confocal Raman micro-spectroscopy has been used to profile the cellular response of macrophage-like immune cells as a result of exposure to a …

Acute Growth Inhibition & Toxicity Analysis Of Nano-Polystyrene Spheres On Raphidocelis Subcapitata, Anthony Reynolds, Michelle Giltrap, Gordon Chambers

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Micro/nano-plastics (MNPs) have been found within many environments and organisms including humans, making them a significant and growing concern. Initial research into the potential detrimental effects these MNPs both from acute and chronic exposure has been ongoing but still requires substantially more data to clarify. This research presents the response of nano-polystyrene (NPS) on Raphidocelis subcapitata, a freshwater alga, under an existing acute toxicity test along with additional analytical techniques to try identifying possible sources of toxicity. R. subcapitata cells were exposed for 72 h to a concentration range of 0–100 mg/l NPS. Growth Inhibition (GI) testing showed the …

Associations Between Home Environment, Children’S And Parents’ Characteristics And Children’S Tv Screen Time Behavior, Carolina Bassu, Clare Corish, John Kearney

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In Ireland, television (TV) screen time is a highly prevalent sedentary behavior among children aged less than five years. Little is known about the influence of parental rules and policies or screen time availability and accessibility within the home on children's TV screen time behaviors. This cross-sectional study aimed to examine the extent to which parents' sociodemographic and sedentary behaviors are associated with children's TV screen time; and to determine the associations between parents' rules and practices, home physical environment and children's daily TV viewing. Three hundred and thirty-two children aged 3-5 years and their parents participated in the study. …

Incoherent Radar Imaging For Breast Cancer Detection And Experimental Validation Against 3d Multimodal Breast Phantoms, Antonio Cuccaro, Angela Dell'aversano, Giuseppe Ruvio, Jacinta Browne, Raffaele Solimene

Articles

: In this paper we consider radar approaches for breast cancer detection. The aim is to give a brief review of the main features of incoherent methods, based on beam-forming and Multiple SIgnal Classification (MUSIC) algorithms, that we have recently developed, and to compare them with classical coherent beam-forming. Those methods have the remarkable advantage of not requiring antenna characterization/compensation, which can be problematic in view of the close (to the breast) proximity set-up usually employed in breast imaging. Moreover, we proceed to an experimental validation of one of the incoherent methods, i.e., the I-MUSIC, using the multimodal breast phantom …

Raman Spectral Cytopathology For Cancer Diagnostic Applications, Damien Traynor, Isha Behl, Declan O'Dea, Franck Bonnier, Siobhan Nicholson, Finbar O'Connell, Aoife Maguire, Stephen Flint, Sheila Galvin, Claire M. Healy, Cara M. Martin, John J. O'Leary, Alison Malkin, Hugh J. Byrne, Fiona M. Lyng

Articles

Raman spectroscopy can provide a rapid, label-free, nondestructive measurement of the chemical fingerprint of a sample and has shown potential for cancer screening and diagnosis. Here we report a protocol for Raman microspectroscopic analysis of different exfoliative cytology samples (cervical, oral and lung), covering sample preparation, spectral acquisition, preprocessing and data analysis. The protocol takes 2 h 20 min for sample preparation, measurement and data preprocessing and up to 8 h for a complete analysis. A key feature of the protocol is that it uses the same sample preparation procedure as commonly used in diagnostic cytology laboratories (i.e., liquid-based cytology …

Developing A Framework For Professional Practice In Applied Performance Analysis, Denise Martin, Peter G. O'Donohoghue, Jonathan Bradley, Denise Mcgrath

Articles

Applied performance analysts are increasingly seen as sports science professionals; however, there is no accepted framework for professional practice. The purpose of this study is to develop and validate a framework for professional practice in applied performance analysis (PA) which identifies the components of practice and the expertise underpinning it.

A six-step framework analysis was conducted: (1) An initial conceptual framework was devised based on well-accepted components of applied practice; (2) A systematic review identified 90 papers relating to applied PA practice; (3) Papers were coded to the initial framework and additional themes recorded; (4) Themes were analysed and synthesised …

Food Industries Wastewater Recycling For Biodiesel Production Through Microalgal Remediation, Divakar Dahiya, Uttam K. Ghosh, Poonam S. Nigam, Amit Jaiswal

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This article is an overview of a biosystem of food-industry wastewater (WW) treatment using microalgae towards circular bioeconomy through biosynthesis of compounds of added-value. Focusing on circular bioeconomy with concern to environmental pollution, the management of water-resource and energy-crisis could be combined; by upgrading conventional WW treatment and simultaneously producing a renewable and sustainable source of energy algal-lipids for biodiesel production. Phyco-remediation of food WW using microalgae has revealed many advantages that can fulfill new demands for the WW treatment. WWs can be valuable resources of micronutrients and organic content (carbon source) for algal cultivation. In this review, prospective routes …

Digital Health’S Impact On Integrated Care, Carer Empowerment And Patient-Centeredness For Persons Living With Dementia, Nicole Gross, Vivienne Byers, Susi Geiger

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E-health or digital health technologies endeavour to connect key stakeholders and thereby lay the foundation for better integrated as well as potentially more patient-centered care. However, despite the promise of empowerment, efficiency and value, digital health has yet to become part of the daily lives of the people who care for persons living with dementia

The Value Of Leadership Practices When There Is No One To Lead: A Nascent Entrepreneurship Context, Lucia Walsh, Bruce Martin

Articles

Although a considerable amount of literature shows how entrepreneurs develop and utilize social capital to create and grow their ventures, there is scant learning on how nascent entrepreneurs with few ties actually create and utilize social capital to help turn their early ideas into ventures. This paper reveals the role of relational leadership in social capital development and shows how it enhances persistence among very early-stage nascent entrepreneurs, even when they have no employees or partners to lead. Learning from our 18-month in-depth case studies of early-stage nascent entrepreneurs in one European country is used to propose a theory of …

Drug Education Best Practice For Health, Community And Youth Workers: A Practical And Accessible Tool-Kit, Clay Darcy

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Objectives Drug education is delivered by a broad spectrum of multi-disciplinary practitioners within the fields of health promotion, drug prevention and treatment, social care, and community and youth work. However, drug education is often misunderstood or conflated with drug information and/or drug prevention. This ambiguity of understanding is problematic and, when coupled with drug education being delivered by practitioners who may not have formal training in drug education, can result in poor delivery, poor participant engagement and poor outcomes. This paper provides conceptual clarity for practitioners on drug education, differentiating it from other approaches to drug issues. Methods The paper …

Developing Non‑Residential Building Stock Archetypes For Lci—A German Case Study Of Office And Administration Buildings, Michael Buschka, Julian Bischoff, Christina Meier-Dotzler, Werner Lang

Articles

To accomplish the national and international climate goals, building renovation and optimisation of their energy and resource efficiency are essential. Thus, reliable information on the building stock (BS) is necessary. Most previous building typologies are focussing on residential buildings and the operational phase. This paper shows the development of a methodology for generating non-residential building (NRB) typologies for life cycle inventory analysis (LCI) of building constructions. Hereby, archetypes of office, administration and department (OAD) buildings are developed, exemplarily for the German NRB stock.

Forward: Teanga, 11(Special Issue 11), Pp. Iii-Xiii, Irene Murtagh, Lorraine Leeson

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Welcome to this special issue of TEANGA, which presents a selection of papers on the linguistics and applied linguistics of Irish Sign Language. This publication is timely, coming in the academic year that celebrates the nineteenth anniversary of the establishment of the Centre for Deaf Studies at Trinity College Dublin (est. 2001), and the year in which when Irish Sign Language Act (2017) is due to formally commence

Infrared Based Saliva Screening Test For Covid-19, Bayden R. Wood, Kamila Kochan, Diana E. Bedolla, Natalia Salazar‐Quiroz, Samantha L. Grimley, David Perezguaita, Matthew J. Baker, Jitraporn Vongsvivut, Mark J. Tobin, Keith R. Bambery, Dale Christensen, Shivani Pasricha, Anthony K. Eden, Aaron Mclean

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Abstract: Severe acute respiratory syndrome coronavirus 2 has resulted in an unprecedented need for diagnostic testing that is critical in controlling the spread of COVID-19. We propose a portable infrared spectrometer with purpose-built transflection accessory for rapid point-of-care detection of COVID-19 markers in saliva. Initially, purified virion particles were characterized with Raman spectroscopy, synchrotron infrared (IR) and AFM-IR. A data set comprising 171 transflection infrared spectra from 29 patients testing positive for SARS-CoV-2 by RT-qPCR and 28 testing negative, was modeled using Monte Carlo Double Cross Validation with 50 randomized test and model sets. The testing sensitivity was 93 % …

In Silico And In Vitro Screening For Potential Anticancer Candidates Targeting Gpr120, Ajay Pal, James Curtin, Gemma K. Kinsella

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The G-protein coupled receptor - GPR120 has recently been implicated as a novel target for colorectal cancer (CRC) and other cancer managements. In this study, a homology model of GPR120S (short isoform) was generated to identify potential anti-cancer compounds targeting the GPR120 receptor using a combined in silico docking-based virtual screening (DBVS), structure-activity relationships (SAR) and in vitro screening approach. SPECS database of synthetic chemical compounds (~350,000) was screened using the developed GPR120S model to identify molecules binding to the orthosteric binding pocket followed by an AutoDock SMINA rigid-flexible docking protocol. The best 13 hit molecules were then tested in …

Ursolic Acid Inhibits Collective Cell Migration And Promotes Jnk-Dependent Lysosomal Associated Cell Death In Gioblastoma Multiforme Cells, Gillian Conway, Diamante Zizyte, Julie Mondala, Zhonglei He, Lorna Lynam, Mathilde Lecourt, Orla L. Howe, James Curtin

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Ursolic acid (UA) is a bioactive compound which has demonstrated therapeutic efficacy in a variety of cancer cell lines. UA activates various signalling pathways in Glioblastoma multiforme (GBM) and offers a promising starting point in drug discovery; however, understanding the relationship between cell death and migration has yet to be elucidated. UA induces a dose dependent cytotoxic response demonstrated by flow cytometry and biochemical cytotoxicity assays. Inhibitor and fluorescent probe studies demonstrate that UA induces a caspase independent, JNK dependent, mechanism of cell death. Migration studies established that UA inhibits GBM collective cell migration in a time dependent manner that …

Fruits And Vegetables In The Management Of Underlying Conditions For Covid-19 High-Risk Groups, Nora Moreb, Ahmed Albandary, Swarna Jaiswal, Amit Jaiswal

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: SARS-CoV-2 or COVID-19 is a novel coronavirus, which is the cause of the current pandemic with 107,411,561 infections and 2,351,195 death worldwide so far. There are multiple symptoms that are linked with the infection of COVID-19 such as coughing, shortness of breath, congestion together with fatigue, fever, loss of taste or smell, headaches, diarrhea, vomiting, and loss of appetite. The lack of or early stage of development of a cure for COVID-19 illness, there is need for insuring the best possible position of health to be able to fight the virus naturally through a robust immune system to limit …

Salmonella, Food Safety And Food Handling Practices, Olugbenga Ehuwa, Amit Jaiswal, Swarna Jaiswal

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: Salmonellosis is the second most reported gastrointestinal disorder in the EU resulting from the consumption of Salmonella-contaminated foods. Symptoms include gastroenteritis, abdominal cramps, bloody diarrhoea, fever, myalgia, headache, nausea and vomiting. In 2018, Salmonella accounted for more than half of the numbers of foodborne outbreak illnesses reported in the EU. Salmonella contamination is mostly associated with produce such as poultry, cattle and their feeds but other products such as dried foods, infant formula, fruit and vegetable products and pets have become important. Efforts aimed at controlling Salmonella are being made. For example, legislation and measures put in place reduced …

A Kitchen At The Heart Of A School–An Investigation Into School Meals In The Republic Of Ireland, Michelle Darmody

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Free school meals provide support to vulnerable families in the Republic of Ireland. Funding is allocated as part of an anti-poverty strategy. An investigation was carried out to discover if the school meal could be used to provide nutritious scratch-cooked food as well as providing opportunities for increased socialisation and pedagogy. Food affects students in a myriad of ways and schools are in a unique position to guide what and how young people eat. This article draws on data from an ethnographic study in an inner city Dublin school.

Doctors Can’T Be Doctors All Of The Time: A Qualitative Study Of How General Practitioners And Medical Students Negotiate Public-Professional And Private-Personal Realms Using Social Media, Megan Marshall, Vikram Niranjan, Eimear Spain, Joe Macdonagh, Jane O'Doherty, Raymond O'Connor, Andrew O'Regan

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The objective of this study is to explore the experiences and perspectives of general practitioners’ and medical students’ use of, and behaviour on, social media and to understand how they negotiate threats to professional and personal life on social media.

A New Epoch For Community Renewable Energy Co-Operatives In Ireland? An Exploration Of The Factors Influencing Their Development, Gerard Doyle

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The paper outlines the capacities required for community groups to successfully establish and maintain renewable energy co-operatives in Ireland. The paper finds that community groups that successfully establish renewable energy co-operatives must possess high levels of resilience, have access to technical expertise, and have appropriate finance. It also highlights how it is crucial that at least one member of each renewable energy co-operative engages with state agencies and the community. Pringle’s (2015) theoretical framework applied in this paper focuses on the capacities required for the successful implementation of community renewable energy projects (which include community renewable energy co-operatives) in rural …

You Can't Lose A Game If You Don't Play The Game: Exploring The Ethics Of Gamification In Education, Dympna O'Sullivan, Ioannis Stavrakakis, Damian Gordon, Andrea Curley, Brendan Tierney, Emma Murphy, Michael Collins, Anna Becevel

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Gamification has been hailed as a meaningful solution to the perennial challenge of sustaining student attention in class. It uses facets of gameplay in an educational context, including things such as points, leaderboards and badges. These are clearly efforts to make the student experience more entertaining and engaging, but nonetheless, they are also clearly digital nudges and attempts to change the students’ behaviours and attitudes to a specific set of concepts, and in which case they must, and should, be subject to the same ethical scrutiny as any other form of persuasion technique, as they may be unintentionally eroding the …

From Overt Threat To Invisible Presence: Discursive Shifts In Representations Of Gender In Menstrual Product Advertising, Valerie Gannon, Olivia Freeman, Rachel Campbell

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The menstrual product brand ‘Always’ and its #LikeAGirl campaign has made headlines for being at the forefront of a menstrual liberation, championing female empowerment and gender equality. This paper utilises a visual discourse analysis approach (Rose, 2016) to explore the discursive shifts in ‘Always’ advertisements over the past four decades. Specifically, the question as to how the construction of menstruation has changed over time in the advertising discourse of the ‘Always’ brand is addressed. Three dominant discourses of menstruation are identified: overt threat, uncontrollable and invisible. These discourses function as strong claims to truth as they reach the everyday life …

Responding To Stigmatization: How To Resist And Overcome The Stigma Of Unemployment, Paul Donnelly, Lucia Garcia-Lorenzo, Lucia Sell-Trujillo

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Organization research on stigma has mostly focused on the stigmatized, limiting the scope for exploring what is possible and lacking recognition of the structural conditions and unequal power relations that create and sustain stigma. Consequently, it overlooks how actors can organize to resist and potentially overcome stigmatization altogether. Addressing this question empirically, we studied the long-term unemployed in Spain using a longitudinal qualitative research design. We develop a typology of responses to stigmatization – getting stuck, getting by, getting out, getting back at and getting organized – that advances our understanding of stigma in several ways. First, our typology captures …

Police Prosecutions And Punitive Instincts, Kate Levine

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This Article makes two contributions to the fields of policing and criminal legal scholarship. First, it sounds a cautionary note about the use of individual prosecutions to remedy police brutality. It argues that the calls for ways to ease the path to more police prosecutions from legal scholars, reformers, and advocates who, at the same time, advocate for a dramatic reduction of the criminal legal system’s footprint, are deeply problematic. It shows that police prosecutions legitimize the criminal legal system while at the same time displaying the same racism and ineffectiveness that have been shown to pervade our prison-backed criminal …

Courts Beyond Judging, Michael C. Pollack

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Across all fifty states, a woefully understudied institution of government is responsible for a broad range of administrative, legislative, law enforcement, and judicial functions. That important institution is the state courts. While the literature has examined the federal courts and federal judges from innumerable angles, study of the state courts as institutions of state government — and not merely as sources of doctrine and resolvers of disputes — has languished. This Article remedies that oversight by drawing attention for the first time to the wide array of roles state courts serve, and by evaluating the suitability of both the allocation …

Defining Who Is An Employee After A.B.5: Trading Uniformity And Simplicity For Expanded Coverage, Edward A. Zelinsky

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My assessment of California’s A.B.5 differs from the evaluation advanced by the advocates and opponents of that legislation: I conclude that A.B.5 made a significant but limited expansion of the coverage of California labor law but at a notable cost. Even as A.B.5 broadened the reach of the Golden State’s labor protections, A.B.5 also made the definition of "employee” more complex and less uniform. Those seeking federal or state legislation like A.B.5 confront the same trade-off under which greater coverage is achieved at the expense of more complexity and less uniformity in the definition of who is an employee. The …

Blockchain Neutrality, Samuel N. Weinstein

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Blockchain technology is transforming how markets work. Blockchains eliminate the need for trusted gatekeepers like banks to execute, verify, and record transactions. In the financial markets, their disruptive potential threatens both Wall Street banks and Silicon Valley venture capitalists. How blockchain technology is regulated will determine whether it encourages or inhibits competition. Some blockchain applications present serious fraud and systemic risks, complicating regulation. This Article explores the antitrust and competition policy challenges blockchain presents and proposes a regulatory strategy, modeled on Internet regulation and net neutrality principles, to unlock blockchain’s competitive potential. It contends that financial regulators should promote blockchain …

New Federalism And Civil Rights Enforcement, Alexander A. Reinert, Joanna C. Schwartz, James E. Pfander

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Calls for change to the infrastructure of civil rights enforcement have grown more insistent in the past several years, attracting support from a wide range of advocates, scholars, and federal, state, and local officials. Much of the attention has focused on federal-level reforms, including proposals to overrule Supreme Court doctrines that stop many civil rights lawsuits in their tracks. But state and local officials share responsibility for the enforcement of civil rights and have underappreciated powers to adopt reforms of their own. This Article evaluates a range of state and local interventions, including the adoption of state law causes of …