Digital Commons Network^™

Identification Of Flexural Rigidity In A Kirchhoff Plates Model Using A Convex Objective And Continuous Newton Method, Baasansuren Jadamba, Akhtar A. Khan, Raphael Kahler, F. Raciti, B. Winkler

Articles

This work provides a detailed theoretical and numerical study of the inverse problem of identifying flexural rigidity in Kirchhoff plate models. From a mathematical standpoint, this inverse problem requires estimating a variable coefficient in a fourth-order boundary value problem.This inverse problem and related estimation problems associated with general plates and shellmodels have been investigated by numerous researchers through an optimization framework using the output least-squares (OLSs) formulation. OLS yields a nonconvex framework and hence it is suitable for investigating only the local behavior of the solution. In this work, we propose a new convex framework for the inverse problem of …

Knowledge Sharing In Organisations: A Bayesian Analysis Of The Role Of Reciprocity And Formal Structure, Alberto Caimo, Alessandro Lomi

Articles

We examine the conditions under which knowledge embedded in advice relations is likely to reach across intraorganizational boundaries and be shared between distant organizational members. We emphasize boundary-crossing relations because activities of knowledge transfer and sharing across subunit boundaries are systematically related to desirable organizational outcomes. Our main objective is to understand how organizational and social processes interact to sustain the transfer of knowledge carried by advice relations. Using original fieldwork and data that we have collected on members of the top management team in a multiunit industrial group, we show that knowledge embedded in task advice relations is unlikely …

Dit-Topcon Internship Experience, Audrey Martin, Abigail Iversen

Articles

The Technological University Dublin (DIT: http://www.dit.ie/) is one of the largest Higher Education Institutes in Ireland, with 20,000 students registered and over 2000 members of staff. It has been providing technological higher education for over one hundred and twenty years encompassing the full spectrum of Third Level programmes. During that time the Institute's alumni have played important roles in technical and scientific innovation, economic and social development and culture and education both in Ireland and internationally.

The CEO of Topcon Positioning Systems Inc., Ray O’Connor is a DIT School of Surveying alumnus and in October 2013 Ray visited his …

A Class Of High-Order Runge-Kutta-Chebyshev Stability Polynomials, Stephen O'Sullivan

Articles

The analytic form of a new class of factorized Runge-Kutta-Chebyshev (FRKC) stability polynomials of arbitrary order N is presented. Roots of FRKC stability polynomials of degree L = MN are used to construct explicit schemes comprising L forward Euler stages with internal stability ensured through a sequencing algorithm which limits the internal amplification factors to ~ L². The associated stability domain scales as M² along the real axis. Marginally stable real-valued points on the interior of the stability domain are removed via a prescribed damping procedure. By construction, FRKC schemes meet all linear order conditions; for nonlinear …

A Hamiltonian Approach To Wave-Current Interactions In Two-Layer Fluids, Adrian Constantin, Rossen Ivanov

Articles

We provide a Hamiltonian formulation for the governing equations describing the two-dimensional nonlinear interaction between coupled surfacewaves, internalwaves, and an underlying current with piecewise constant vorticity, in a two-layered fluid overlying a flat bed. This Hamiltonian structure is a starting point for the derivation of simpler models, which can be obtained systematically by expanding the Hamiltonian in dimensionless parameters. These enable an in-depth study of the coupling between the surface and internal waves, and how both these wave systems interact with the background current.

Will Oscillating Wave Surge Converters Survive Tsunamis?, Laura Cooke, P. Christodoulides, E. Renzi, T. Stefanakis, F. Dias

Articles

With an increasing emphasis on renewable energy resources, wave power technology is becoming one of the realistic solutions. However, the 2011 tsunami in Japan was a harsh reminder of the ferocity of the ocean. It is known that tsunamis are nearly undetectable in the open ocean but as the wave approaches the shore its energy is compressed, creating large destructive waves. The question posed here is whether an oscillating wave surge converter (OWSC) could withstand the force of an incoming tsunami. Several tools are used to provide an answer: an analytical 3D model developed within the framework of linear theory, …

Postgraduate Researchers Who Teach: How Can National Policy And The Structured Phd Centralise This Forgotten Tribe And Celebrate Their Skills In Tackling Some Of The Current Challenges In Irish Higher Education?, Barry Ryan

Articles

Some of the current challenges faced by Higher Education Institutes (HEIs) include financial constraints imposed by the economic downturn, the requirement to ‘teach more with less’, and the use of the knowledge based economy to drive economic stabilisation and recovery. HEIs have adopted a number of approaches to address these drivers of change including centralising the postgraduate research student who teaches. The role of these postgraduate research students is one that is not often highlighted within the fabric of the HEI; however, these transient researchers play two key roles: full-time researchers and novice educators. Centralising and celebrating the research skills …

Algebraic And Numerical Exploration Of Free Energies For Materials With Memory, John Murrough Golden, Giovambattista Amendola, Mauro Fabrizio

Articles

Abstract. We study the forms of a range of free energy functionals for materials with memory for two types of strain history, namely sinusoidal and ex- ponential behaviours. The work deals with discrete spectrum materials, which are those with relaxation functions given by sums of decaying exponentials.

Integrating Emerging Cryptographic Engineering Research And Security Education, Mehran Mozaffari Kermani, Reza Azarderakhsh

Articles

Unlike traditional embedded systems such as secure smart cards, emerging secure deeply embedded systems, e.g., implantable and wearable medical devices, have larger “attack surface”. A security breach in such systems which are embedded deeply in human bodies or objects would be life-threatening, for which adopting traditional solutions might not be practical due to tight constraints of these often-battery-powered systems. Unfortunately, although emerging cryptographic engineering research mechanisms have started solving this critical problem, university education (at both graduate and undergraduate level) lags comparably. One of the pivotal reasons for such a lag is the multi-disciplinary nature of the emerging security bottlenecks …

Communication: Analytic Continuation Of The Virial Series Through The Critical Point Using Parametric Approximants, Nathaniel S. Barlow, Andrew J. Schultz, Steven J. Weinstein, David A. Kofke

Articles

The mathematical structure imposed by the thermodynamic critical point motivates an approximant that synthesizes two theoretically sound equations of state: the parametric and the virial. The former is constructed to describe the critical region, incorporating all scaling laws; the latter is an expansion about zero density, developed from molecular considerations. The approximant is shown to yield an equation of state capable of accurately describing properties over a large portion of the thermodynamic parameter space, far greater than that covered by each treatment alone.

Taxation And Surveillance: An Agenda, Michael Hatfield

Articles

Among government agencies, the IRS likely has the surest legal claim to the most information about the most Americans: their hobbies, religious affiliations, reading activities, travel, and medical information are all potentially tax relevant. Privacy scholars have studied the arrival of Big Data, the internet-of-things, and the cooperation of private companies with the government in surveillance, but neither privacy nor tax scholars have considered how these technological advances should impact the U.S. tax system. As government agencies and private companies increasingly pursue what has been described as the “growing gush of data,” the use of these technologies in tax administration …

Push, Pull, And Spill: A Transdisciplinary Case Study In Municipal Open Government, Jan Whittington, Ryan Calo, Mike Simon, Jesse Woo, Meg Young, Perter Schmiedeskamp

Articles

Municipal open data raises hopes and concerns. The activities of cities produce a wide array of data, data that is vastly enriched by ubiquitous computing. Municipal data is opened as it is pushed to, pulled by, and spilled to the public through online portals, requests for public records, and releases by cities and their vendors, contractors, and partners. By opening data, cities hope to raise public trust and prompt innovation. Municipal data, however, is often about the people who live, work, and travel in the city. By opening data, cities raise concern for privacy and social justice.

This article presents …

Robotics And The Lessons Of Cyberlaw, Ryan Calo

Articles

Two decades of analysis have produced a rich set of insights as to how the law should apply to the Internet’s peculiar characteristics. But, in the meantime, technology has not stood still. The same public and private institutions that developed the Internet, from the armed forces to search engines, have initiated a significant shift toward developing robotics and artificial intelligence.

This Article is the first to examine what the introduction of a new, equally transformative technology means for cyberlaw and policy. Robotics has a different set of essential qualities than the Internet and accordingly will raise distinct legal issues. Robotics …

The Lost "Art" Of The Patent System, Sean M. O'Connor

Articles

Patent systems emerged in the early modern period of the West to incentivize development and dissemination of skills-based artisanal innovations. This approach appears to have been adopted by the Framers in drafting the Intellectual Property Clause.

Only later, in the Industrial Revolution, did ‘‘science’’ and ‘‘technology’’ begin to displace ‘‘art’’ as the perceived object of the U.S. patent system. This was in large part because of the emergence of the concept of ‘‘technology’’ itself as science-based innovation in artisanal and mechanized production.

The loss of an ‘‘art’’-based concept of the patent system is arguably causing some of the confusion over …

A Quantum Theory Of Consciousness May Require A Paradigm Shift In Biology, Maurice Goodman

Articles

It is often assumed that the known physical laws form a closed system and are complete. It is also assumed that biological theories require no additional principles that are fundamental other than those we already know. Assumptions such as these are acting as a barrier to progress in biological theories and an understanding of consciousness. This paper examines the unexplained inconsistencies among fundamental particles and forces and the fundamental gaps in our knowledge of biology and the cell in particular that may impact on such progress. Also, the laws of quantum mechanics are examined and found to be grossly incomplete. …

Recruitment And Selection Strategies In Optometric Education Towards Addressing Human Resource Disparities In Sub-Saharan Africa, Vanessa Moodley, James Loughman, Kovin S. Naidoo

Articles

The dire need for eye care services and a dearth of human resources (HR) in sub-Saharan Africa motivated the setting up of new optometry programmes. However, to make a meaningful impact, geographical, gender, economic and educational disparities must additionally be addressed. A qualitative study utilizing purposive sampling to select academic leadership and students from optometry programmes in sub-Saharan Africa was conducted. Individual and focus group interviews produced data that were coded and analysed using a deductive thematic analysis approach. The themes that emerged as contributing to disparities in access through recruitment and selection were institutional barriers (student intake numbers, programme …

Dual Targeted Immunotherapy Via In Vivo Delivery Of Bio-Hybrid Rnai-Peptide Nanoparticles To Tumour-Associated Macrophages And Cancer Cells, Joao Conde, Chenchen Bao, Yeqi Tan, Daxiang Cui, Elazier Edelman, Helena Azevedo, Hugh Byrne, Natalie Artzi, Furong Tian

Articles

Lung cancer is associated with very poor prognosis and considered one of the leading causes of death worldwide. Here, we present highly potent and selective bio-hybrid RNAi-peptide nanoparticles that can induce specific and long-lasting gene therapy in inflammatory tumour associated macrophages (TAMs), via an immune modulation of the tumour milieu combined with tumour suppressor effects. Our data prove that passive gene silencing can be achieved in cancer cells using regular RNAi NPs. When combined with M2 peptide-based targeted immunotherapy that immuno-modulates TAMs cell-population, a synergistic effect and long-lived tumour eradication can be observed along with increased mice survival. Treatment with …

The Contribution Of Non-Thermal And Advanced Oxidation Technologies Towards Dissipation Of Pesticide Residues, N. Misra

Articles

Background

The use of pesticides has stabilised the food production to a great extent and their usage cannot be avoided anymore. Nevertheless, common food processing operations always allowed dissipating pesticide residues in foods to some extent. Within the food science community and the food processing sector, non-thermal food technologies are being researched and commercialised at a great pace over the past three decades.

Scope and Approach

In this review we provide a critical analysis of the literature pertinent to the fate of pesticide residues during non-thermal processing of solid and liquid foods. We also identify the opportunities for further development …

Computational Development Of Selective Nnos Inhibitors: Binding Modes And Pharmacokinetic Considerations, Adam Curtin, Gemma K. Kinsella, John Stephens

Articles

Abstract: Neuronal nitric oxide synthase (nNOS) produces the key signalling mediator nitric oxide, (NO). This gaseous, free radical molecule modulates a vast array of biological processes, from vascular pressure to immune responses and neurological signalling cascades. Overproduction of NO has been implicated in conditions including Alzheimer’s disease, Parkinson’s disease and schizophrenia. Inhibition of nNOS therefore offers a potential therapeutic approach for treatment of these conditions. This endeavour is made more complex by the fact that there are two other isoforms of nitric oxide synthase (NOS), endothelial NOS (eNOS) and inducible NOS (iNOS). The selectivity of nNOS inhibitors is therefore a …

A Mathematical Model Of Meat Cooking Based On Polymer-Solvent Analogy, M. Chapwanya, Nissreen Misra

Articles

Mathematical modelling of transport phenomena in food processes is vital to understand the process dynamics. In this work, we study the process of double sided cooking of meat by developing a mathematical model for the simultaneous heat and mass transfer. The constitutive equations for the heat and mass transport are based on Fourier conduction, and the Flory–Huggins theory respectively, formulated for a two-phase transport inside a porous medium. We investigate a reduced one-dimensional case to verify the model, by applying appropriate boundary conditions. The results of the simulation agree well with experimental findings reported in literature. Finally, we comment upon …

On The Dynamics Of Internal Waves Interacting With The Equatorial Undercurrent, Alan Compelli, Rossen Ivanov

Articles

The interaction of the nonlinear internal waves with a nonuniform current with a specific form, characteristic for the equatorial undercurrent, is studied. The current has no vorticity in the layer, where the internal wave motion takes place. We show that the nonzero vorticity that might be occuring in other layers of the current does not affect the wave motion. The equations of motion are formulated as a Hamiltonian system.

Hamiltonian Approach To Internal Wave-Current Interactions In A Two-Media Fluid With A Rigid Lid, Alan Compelli, Rossen Ivanov

Articles

We examine a two-media 2-dimensional fluid system consisting of a lower medium bounded underneath by a flatbed and an upper medium with a free surface with wind generated surface waves but considered bounded above by a lid by an assumption that surface waves have negligible amplitude. An internal wave driven by gravity which propagates in the positive x-direction acts as a free common interface between the media. The current is such that it is zero at the flatbed but a negative constant, due to an assumption that surface winds blow in the negative x-direction, at the lid. We are concerned …

Identification Of Key Proteins In Human Epithelial Cells Responding To Bystander Signals From Irradiated Trout Skin, Hayley Furlong, Richard Smith, Jiaxi Wang, Colin Seymour, Carmel Mothersill, Orla L. Howe

Articles

Radiation-induced bystander signaling has been found to occur in live rainbow trout fish (Oncorhynchus mykiss). This article reports identification of key proteomic changes in a bystander reporter cell line (HaCaT) grown in low-dose irradiated tissue-conditioned media (ITCM) from rainbow trout fish. In vitro explant cultures were generated from the skin of fish previously exposed to low doses (0.1 and 0.5 Gy) of X-ray radiation in vivo. The ITCM was harvested from all donor explant cultures and placed on recipient HaCaT cells to observe any change in protein expression caused by the bystander signals. Proteomic methods using 2-dimensional (2D) gel electrophoresis …

Patent Scope And Enablement In Rapidly Developing Arts, Alan L. Durham

Articles

The claims of a patent and its enabling disclosure must be commensurate in scope However because of the openended nature of most patent claims in fields of rapidlydeveloping technology it is almost inevitable that before the patent has expired the claims will read on embodiments that the specification does not teach The current law on scope enablement is the source of much confusion Because enablement must be judged from a filingdate perspective some cases dismiss later advancements eg a newlydiscovered species within a claimed genus as irrelevant Other cases in contrast hold patent claims invalid because they exceed the scope …

Disambiguating Company Names In Microblog Text Using Clustering For Online Reputation Management, Fernando Perez-Tellez, John Cardiff, Paolo Rosso, David Pinto

Articles

Twitter is used by millions of users to publish brief messages (tweets) with the purpose of sharing experiences and/or opinions about a product or service. There is a clear need for systems that can mine these messages in order to derive information about the collective thinking of twitterers (e.g. for opinion or sentiment analysis). Tweet analysis is a very important task because comments, opinions, suggestions, complaints etc. can be used for marketing strategies or for determining information on a company’s reputation. For this purpose, it is necessary to automatically establish whether a tweet refers to a company or not, when …

A System Dynamics View Of The Acute Bed Blockage Problem In The Irish Healthcare System, Waleed Abo Hamad, Wael Rashwan, Amr Arisha

Articles

Global population ageing is creating immense pressures on hospitals and other healthcare services, compromising their abilities to meet the growing demand from elderly patients. Current demand–supply gaps result in prolonged waiting times in emergency departments (EDs), and several studies have focused on improving ED performance. However, the overcrowding in EDs generally stems from delayed patient flows to inpatient wards – which are congested with inpatients waiting for beds in post-acute facilities. This problem of bed blocking in acute hospitals causes substantial cost burdens on hospitals. This study presents a system dynamics methodology to model the dynamic flow of elderly patients …

The Case For Categorical Nonenforcement, Leigh Osofsky

Articles

No abstract provided.

Diffractive Optical Elements With A Large Angle Of Operation Recorded In Acrylamide Based Photopolymer On Flexible Substrates, Hoda Akbari, Izabela Naydenova, Lina Persechini, Sean Garner, Pat Cimo, Suzanne Martin

Articles

A holographic device characterised by a large angular range of operation is under development. The aim of this study is to increase the angular working range of the diffractive lens by stacking three layers of high efficiency optical elements on top of each other so that light is collected (and focussed) from a broader range of angles. The angular range of each individual lens element is important, and work has already been done in an acrylamide-based photosensitive polymer to broaden the angular range of individual elements using holographic recording at a low spatial frequency.This paper reports new results on the …

Antimicrobial Properties Of Nano-Silver: A Cautionary Approach To Ionic Interference, Kate Sheehy, Alan Casey, Anna Murphy, Gordon Chambers

Articles

Hypothesis: Metallic nanoparticles such as nano-silver have found many applications as alternative antimicrobials in recent years. However methods for determining their proposed antimicrobial activity have received little attention to date. The disk diffusion assay is commonly used as a demonstration of antimicrobial properties and is a regular feature in synthetic nanoparticle papers. The aim of this study was to assess its effectiveness in demonstrating the ‘‘nanoparticle specific’’ antimicrobial properties in the absence of ionic contributions from unreacted reducing agents and or impurities. Experiments: The disk diffusion assay was carried out on a range of silver nanoparticles, both in-house synthesised and …

Competitive Evaluation Of Data Mining Algorithms For Use In Cassification Of Leukocyte Subtypes With Raman Microspectroscopy, Adrian Maguire, I. Vega-Carrascal, Jane Bryant, Lisa White, Orla Howe, Fiona Lyng, Aidan Meade

Articles

Raman microspectroscopy has been investigated for some time for use in label-free cell sorting devices. These approaches require coupling of the Raman spectrometer to complex data mining algorithms for identification of cellular subtypes such as the leukocyte subpopulations of lymphocytes and monocytes. In this study, three distinct multivariate classification approaches, (PCA-LDA, SVMs and Random Forests) are developed and tested on their ability to classify the cellular subtype in extracted peripheral blood mononuclear cells (T-cell lymphocytes from myeloid cells), and are evaluated in terms of their respective classification performance. A strategy for optimisation of each of the classification algorithm is presented …