Digital Commons Network^™

Maths In Prison, Catherine Byrne, Michael Carr

Articles

I teach maths to all levels in an adult male remand prison in Ireland and am also studying for a PhD in maths in prison education in Technological University Dublin (DIT). This paper describes recent initiatives piloted by maths teachers and school management to increase attendance, engagement and certification in maths. It assesses the effects of the initiatives and looks at future potential in this setting and in others. To set the paper in context, I begin by describing a typical day as a prison maths teacher.

Raman Spectroscopic Analysis Of Oral Squamous Cell Carcinoma And Oral Dysplasia In The High-Wavenumber Region, Hugh Byrne, Luis Felipe Carvalho, Fiona Lyng, Franck Bonnier

Articles

Raman spectroscopy can provide a molecular-level signature of the biochemical composition and structure of cells with excellent spatial resolution and could be useful to monitor changes in composition for early stage and non-invasive cancer diagnosis, both ex-vivo and in vivo. In particular, the fingerprint spectral region (400–1,800 cm^-1) has been shown to be very promising for optical biopsy purposes. However, limitations to discrimination of dysplastic and inflammatory processes based on the fingerprint region still persist. In addition, the Raman spectral signal of dysplastic cells is one important source of misdiagnosis of normal versus pathological tissues. The high wavenumber …

Fatigue Modeling Via Mammalian Auditory System For Prediction Of Noise Induced Hearing Loss, Pengfei Sun, Jun Qin, Kathleen Campbell

Articles

Noise induced hearing loss (NIHL) remains as a severe health problem worldwide. Existing noise metrics and modeling for evaluation of NIHL are limited on prediction of gradually developing NIHL (GDHL) caused by high-level occupational noise. In this study, we proposed two auditory fatigue based models, including equal velocity level (EVL) and complex velocity level (CVL), which combine the high-cycle fatigue theory with the mammalian auditory model, to predict GDHL. The mammalian auditory model is introduced by combining the transfer function of the external-middle ear and the triple-path nonlinear (TRNL) filter to obtain velocities of basilar membrane (BM) in cochlea. The …

Laboratory Scale Optimization Of Alkali Pretreatment For Improvingenzymatic Hydrolysis Of Sweet Sorghum Bagasse, Arosha L. Umagiliyage, Ruplal Choudhary, Yanna Liang, John Haddock, Dennis G. Watson

Articles

Sweet sorghum has been identified as a promising feedstock for biological conversion to fuels as wellas other chemicals. The lignocellulosic stalk of sweet sorghum, called sweet sorghum bagasse (SSB) isa potential source of lignocellulosic biofuel. The primary goal of this study was to determine optimalalkali (lime: Ca(OH)2and lye: NaOH) pretreatment conditions to obtain higher yield of total reducingsugar while reducing the lignin content for biofuel production from SSB. Biomass conversion and ligninremoval were simultaneously optimized through four quadratic models analyzed by response surfacemethodology (RSM). The optimal conditions for lime pretreatment was 1.7% (w/v) lime concentration,6.0% (w/v) SSB loading, 2.4 h …

Improving The Electromechanical Performance Of Dialectric Elastomers Using Silicone Rubber And Dopamine Coated Barium Titanate., Liang Jiang, Tony Betts, David Kennedy, Stephen Jerrams

Articles

In this work, a new soft dielectric elastomer (DE) was fabricated from dopamine coated barium titanate particles and silicone rubber (SR). The results show that the dopamine, in addition to coating the barium titanate (BaTiO3, BT), the coated particles (DP-BT) were highly compatible with SR. In order to achieve a maximum voltage-induced deformation, the minimum secant moduli of DEs were obtained in experimentation at a stretch ratio of approximately 1.6 by applying equi-biaxial tensile strain using the bubble inflation method. Additionally, it was found that the addition of DP-BT into SR led to an increased dielectric constant and decreased dielectric …

Audiovisual Processing Is Abnormal In Parkinson's Disease And Correlates With Freezing Of Gait And Disease Duration, Conor Fearon, John Butler, Louise Newman, Timothy Lynch, Richard B. Reilly

Articles

Background: Sensory and perceptual disturbances progress with disease duration in Parkinson’s disease (PD) and probably contribute to motor deficits such as bradykinesia and gait disturbances, including freezing of gait (FOG). Simple reaction time tests are ideal to explore sensory processing, as they require little cognitive processing. Multisensory integration is the ability of the brain to integrate sensory information from multiple modalities into a single coherent percept, which is crucial for complex motor tasks such as gait. 9 10 11 12 13 Objectives: The aims of this study were to: 1. Assess differences in unisensory (auditory and visual) and multisensory processing …

Investigating The Role Of Shape On The Biological Impact Of Gold Nanoparticles In Vitro, Furong Tian, Hugh Byrne, Joao Conde, Tobias Stoeger, Martin Clift,, Alan Casey, Pablo Del Pino, Beatriz Pelaz, Barbara Rothen-Rutishauser,, Giovani Estrada, Jesús De La Fuente

Articles

Aim: To investigate the influence of gold nanoparticle (GNP) geometry on the biochemical response of Calu-3 epithelial cells.

Materials and Methods: Spherical, triangular and hexagonal GNPs were used. The GNP-cell interaction was assessed via atomic absorption spectroscopy (AAS) and transmission electron microscopy (TEM). The biochemical impact of GNPs was determined over 72hrs at [0.0001-1mg/mL].

Results: At 1mg/mL, hexagonal GNPs reduced Calu-3 viability below 60%, showed increased reactive oxygen species production and higher expression of pro-apoptotic markers. A cell mass burden of 1:2:12 as well as number of GNPs per cell (2:1:3) was observed for spherical:triangular:hexagonal GNPs.

Conclusion:

These findings do …

Determination Of Nanoparticle Localisation Within Subcellular Organelles In Vitro Using Raman Spectroscopy, Esen Efeoglu, Mark Keating, Jennifer Mcintyre, Alan Casey, Hugh Byrne

Articles

Ease of sample preparation, narrow spectral bandwidth and minimal influence from water are features of Raman spectroscopy which make it a powerful, label-free way to study a wide range of biological structures and phenomena. In this context, given the concerns over their toxicology arising from their increased production and use, evaluation of nanoparticle uptake and localisation in biological systems and determination of the mechanisms of subcellular interaction and trafficking can provide long-term solutions for nanotoxicology, and potential strategies for nanomedicine. In this study, Raman spectroscopy is explored to monitor the sequential trafficking of nanoparticles through subcellular organelles in-vitro and to …

Raman Spectroscopy For Screening And Diagnosis Of Cervical Cancer, Fiona Lyng, Damien Traynor, Ines Rm Ramos, Franck Bonnier, Hugh Byrne

Articles

Cervical cancer is the fourth most common cancer in women worldwide and mainly affects younger women. The mortality associated with cervical cancer can be reduced if this disease is detected at the pre-cancer stage. Current gold standard methods include cytopathology, HPV testing and histopathology but these methods are limited in terms of subjectivity, cost and time. There is an unmet clinical need for new methods to aid clinicians in the early detection of cervical pre-cancer. These methods should be objective, rapid and require minimal sample preparation. Raman spectroscopy is a vibrational spectroscopic technique by which incident radiation is used to …

Candels Visual Classifications: Scheme, Data Release, And First Results, Jeyhan S. Kartaltepe, Mark Mozena, Dale Kocevski, Daniel H. Mcintosh, Jennifer Lotz, Eric F. Bell, Sandy Faber, Harry Ferguson, David Koo, Robert Bassett, Maksym Bernyk, Kirsten Blancato, Darren Croton, Tomas Dahlen, Frederic Bournaud, Paolo Cassata, Marco Castellano, Edmond Cheung, Christopher J. Conselice, Duilia F. De Mello, Laura Degroot, Jennifer Donley, Javiera Guedes, Norman Grogin, Nimish Hathi, Matt Hilton, Brett Hollon, Anton Koekemoer, Nick Liu, Ray A. Lucas, Marie Martig, Elizabeth Mcgrath, Conor Mcpartland, Bahram Mobasher, Alice Morlock, Erin O'Leary, Mike Peth, Janine Pforr, Annalisa Pillepich, David Rosario, Emmaris Soto, Amber Straughn, Olivia Telford, Ben Sunnquist, Jonathan Trump, Benjamin Weiner, Stijn Wuyts

Articles

We have undertaken an ambitious program to visually classify all galaxies in the five CANDELS fields down to H < 24.5 involving the dedicated efforts of over 65 individual classifiers. Once completed, we expect to have detailed morphological classifications for over 50,000 galaxies spanning 0 < z < 4 over all the fields, with classifications from 3 to 5 independent classifiers for each galaxy. Here, we present our detailed visual classification scheme, which was designed to cover a wide range of CANDELS science goals. This scheme includes the basic Hubble sequence types, but also includes a detailed look at mergers and interactions, the clumpiness of galaxies, k-corrections, and a variety of other structural properties. In this paper, we focus on the first field to be completed—GOODS-S, which has been classified at various depths. The wide area coverage spanning the full field (wide+deep+ERS) includes 7634 galaxies that have been classified by at least three different people. In the deep area of the field, 2534 galaxies have been classified by at least five different people at three different depths. With this paper, we release to the public all of the visual classifications in GOODS-S along with the Perl/Tk GUI that we developed to classify galaxies. We present our initial results here, including an analysis of our internal consistency and comparisons among multiple classifiers as well as a comparison to the Sérsic index. We find that the level of agreement among classifiers is quite good (>70% across the full magnitude range) and depends on both the galaxy magnitude and the galaxy type, with disks showing the highest level of agreement (>50%) and irregulars the lowest (<10%). A comparison of our classifications with the Sérsic index and rest-frame colors shows a clear separation between disk and spheroid populations. Finally, we explore morphological k-corrections between the V-band and H-band observations and find that a small fraction (84 galaxies in total) are classified as being very different between these two bands. These galaxies typically have very clumpy and extended morphology or are very faint in the V-band.

Bis(Spirolactam) 1,3-Double-Armed Calix[4]Arene Compounds And Their Application As Extractants For The Determination Of Heavy Metal Ions, Fintan Kelleher, Mary Deasy, James Ward, Li Li, Fiona Regan

Articles

A number of double-armed calix[4]arene compounds, with proline-derived spirolactam ligating groups on the lower rim, have been synthesised and investigated as extractants of toxic heavy metal ions from aqueous solution. Pedersen’s extraction technique was employed to determine the capability of these new 1,3-distal derived calix[4]arene spiroalactams to extract selected heavy metal ions (e.g. Pb²⁺, Cd²⁺, Zn²⁺, Cu²⁺, Ni²⁺, Co²⁺) from an aqueous phase into an organic phase. The percentage extraction was calculated using UV-vis spectroscopy. All of the compounds synthesised demonstrated good selectivity for the heavy metals selected …

Free Energies And Minimal States For Scalar Linear Viscoelasticity, Giovambattista Amendola, Mauro Fabrizio, John Murrough Golden

Articles

The concept of a minimal state was introduced in recent decades, based on earlier work by Noll. The property that a given quantity is a functional of the minimal state is of central interest in the present work. Using a standard representation of a free energy associated with a linear memory constitutive relation, a new condition, involving linear functionals, is derived which, if satisfied, ensures that the free energy is a functional of the minimal state. Using this result and recent work on constructing free energy functionals, it is shown that if the kernel of the rate of dissipation functional …

Vibrational Spectroscopic Studies To Elucidate The Structure Of Water At Biological Interfaces, Bahar Bahrani, Luke O'Neill, Hugh Byrne

Articles

In biological systems, water takes up to 80% of the volume inside a cell. This water solubilizes the biological macromolecules such as the DNA, proteins and lipids. Recent advancements have shown that the water at the interface of a lipid membrane is structured, as five layers of structured water have been found at this solvent cage. Steady state Raman spectroscopy of water in lipids was performed in an attempt to elucidate the structure of water at the biological interface. Deuterium oxide (heavy water) was employed to hydrate lipid biomolecules. The heavier deuterium atom shifts the molecular vibrations and renders them …

Determination Of The Polymerisation Rate Of A Low-Toxicity Diacetone Acrylamide-Based Holographic Photopolymer Using Raman Spectroscopy, Dervil Cody, Emilia Mihaylova, Luke O'Neill, Izabela Naydenova

Articles

The polymerisation rate of a low-toxicity Diacetone Acrylamide (DA)-based photopolymer has been measured for the first time using Raman spectroscopy. A value for the polymerisation rate of 0.020 s⁻¹ has been obtained for the DA photopolymer by modelling the polymerisation reaction dynamics as a stretched exponential or Kohlrausch decay function. This is significantly lower than the polymerisation rate of 0.100 s⁻¹ measured for the well known Acrylamide (AA)-based photopolymer composition. The effect of the additive glycerol on the polymerisation rate of the DA-based photopolymer has also been investigated. The inclusion of glycerol is observed to increase the rate …

Age-Related Sexual Dimorphism In Temporal Discrimination And In Adult-Onset Dystonia Suggests Gabaergic Mechanisms, John Butler, Ines M. Beiser, Laura Williams, Eavan Mcgovern, Fiona Molloy, Timothy Lynch, Dan G. Healy, Helena Moore, Richard Walsh, Richard B. Reilly, Sean O'Riordan, Cathal Walsh, Michael Hutchinson

Articles

Background: Adult-onset isolated focal dystonia (AOIFD) presenting in early adult life is more frequent in men, whereas in middle age it is female predominant. Temporal discrimination, an endophenotype of adult-onset idiopathic isolated focal dystonia, shows evidence of sexual dimorphism in healthy participants. Objectives: We assessed the distinctive features of age-related sexual dimorphism of (i) sex ratios in dystonia phenotypes and (ii) sexual dimorphism in temporal discrimination in unaffected relatives of cervical dystonia patients. Methods: We performed (i) a meta-regression analysis of the proportion of men in published cohorts of phenotypes of adult-onset dystonia in relation to their mean age of …

Congruent Visual Speech Enhances Entrainment To Continuous Auditory Speech In Noise-Free Conditions, Michael Crosse, John S. Butler, Edmumd Lalor

Articles

Congruent audiovisual speech enhances our ability to comprehend a speaker, even in noise-free conditions. When incongruent auditory and visual information is presented concurrently, it can hinder a listener’s perception and even cause him or her to perceive information that was not presented in either modality. Efforts to investigate the neural basis of these effects have often focused on the special case of discrete audiovisual syllables that are spatially and temporally congruent, with less work done on the case of natural, continuous speech. Recent electrophysiological studies have demonstrated that cortical response measures to continuous auditory speech can be easily obtained using …

Improving Operator Situational Awareness With Wide Area Geographic Data View Displays Of The Electric Power Grid, Esa M. Rantanen, Limor Hochberg, Diego Klabjan, Mingyang Di

Articles

To reduce clutter on wide-area geographic data view displays of electric power systems, substations in geographically compact areas should be spread out and line overlaps and intersections minimized. Such pat- terns optimized with respect to given constraints can be modeled as a multicommodity flow problem. Due to the size of the developed model, we developed two clustering-based iterative algorithms to decompose the global network into smaller regions and then iteratively solve the subproblem in each region by readjusting some values. Three solutions were selected for experimental evaluation. The experimental results were somewhat inconclusive, due to naïve participants, simple task, and …

Student Educational Background, Perceptions And Expectations Towards Optometry: An Emerging Eye Health Profession Mozambique., James Loughman, Ving Fai Chan, Vanessa Raquel Moodley, Luigi Bilotto, Kovin Naidoo

Articles

Background: The University of Lurio, School of Optometry in Mozambique is a new program in Africa. The school, the first to serve Portuguese-speaking Africa, can act as a template for such initiatives in other African countries and other limited-resource settings around the world. A major challenge facing such programs is the lack of knowledge about the profession, which impacts the recruitment of students and their expectations of the program. This study was conducted to understand students’ pre-enrollment educational background, perceptions and career expectations as an optometrist in Mozambique so as to inform future enrollment and other similar initiatives. Methods: First-year …

Diagnostics Need Not Apply, Rebecca S. Eisenberg

Articles

Diagnostic testing helps caregivers and patients understand a patient's condition, predict future outcomes, select appropriate treatments, and determine whether treatment is working. Improvements in diagnostic testing are essential to bringing about the long-heralded promise of personalized medicine. Yet it seems increasingly clear that most important advances in this type of medical technology lie outside the boundaries of patent-eligible subject matter. The clarity of this conclusion has been obscured by ambiguity in the recent decisions of the Supreme Court concerning patent eligibility. Since its 2010 decision in Bilski v. Kappos, the Court has followed a discipline of limiting judicial exclusions from …

A Structurally Based Analytic Model Of Growth And Biomass Dynamics In Single Species Stands Of Conifers, Robin J. Tausch

Articles

A theoretically based analytic model of plant growth in single species conifer communities based on the species fully occupying a site and fully using the site resources is introduced. Model derivations result in a single equation simultaneously describes changes over both, different site conditions (or resources available), and over time for each variable for each species. Leaf area or biomass, or a related plant community measurement, such as site class, can be used as an indicator of available site resources. Relationships over time (years) are determined by the interaction between a stable foliage biomass in balance with site resources, and …

Computational Analysis And Monte Carlo Simulation Of Wave Propagation, Jun Qin

Articles

No abstract provided.

Explaining Trade Agreements: The Practitioners' Story And The Standard Model, Donald H. Regan

Articles

There are two widely accepted explanations of why politically motivated governments make trade agreements. There is an informal explanation, which I shall call the ′practitioners′ story′, even though it is most economists′ informal view as well. And there is a formal explanation in the economics literature, which I shall call the ′standard model′, referring to the basic structure shared by the Bagwell-Staiger and Grossman-Helpman models. Unfortunately, the practitioners′ story and the standard model contradict each other at every crucial point. For example, in the practitioners′ story, trade agreements are about reducing politically motivated protectionism; and getting an agreement depends on …

Cellular Discrimination Using In Vitro Raman Micro Spectroscopy: The Role Of The Nucleolus, Hugh Byrne

Articles

Raman micro spectroscopy has attracted considerable attention over the last few years to explore its possible clinical applications as a non-invasive powerful label-free in vitro screening tool in cancer diagnosis and monitoring, subcellular analysis of biochemical processes, drug uptake, mode of action and mechanisms of interaction as well as toxicity of, for example, chemotherapeutic agents.

However, in order to evaluate accurately the potential of Raman micro spectroscopy for such applications it is essential to optimise measurement and data processing protocols associated with subcellular analysis. To this end, in vitro differentiation of cell lines is a basic proof of concept for …

Effect Of The Condensation Of Hybrid Organic–Inorganic Sol–Gel Materials On The Optical Properties Of Tripan Blue, Craig Hicks, Muhammad Morshed, Garrett Melia, Killian Barton, Brendan Duffy, Mohamed Oubaha

Articles

The work reported in this paper highlights the effect of sol–gel structures on the optical properties of a typical organic dye (Trypan Blue, TB). Three transition-metal-based hybrid sol–gel materials with different structures and morphologies were developed and characterised by TEM. The optical properties of TB were investigated by incorporating it in the different sol–gel materials and the UV–Visible spectra recorded in both liquid and solid state, in thin-coatings cured at temperatures in the range 100– 150 [1]C. These studies revealed two relevant results. First, the sol–gel morphology plays a critical role in the optical properties of the dye. The effect …

Optimal Choice Of Sample Substrate And Laser Wavelength For Raman Spectroscopic Analysis Of Biological Specimen, Hugh Byrne, Laura Kerr, Bryan M. Hennelly

Articles

Raman spectroscopy is an optical technique based on the inelastic scattering of monochromatic light that can be used to identify

the biomolecular composition of biological cells and tissues. It can be used as both an aid for understanding the etiology

of disease and for accurate clinical diagnostics when combined with multivariate statistical algorithms. This method is nondestructive,potentially non-invasive and can be applied in vitro or in vivo directly or via a fiber optic probe. However, there exists a high degree of variability across experimental protocols, some of which result in large background signals that can often overpower the weak Raman …

A Simple Theory Of Complex Valuation, Anthony Casey, Julia Simon-Kerr

Articles

No abstract provided.

Wheel And Star-Critical Ramsey Numbers For Quadrilateral, Yali Wu, Yongqi Sun, Stanislaw Radziszowski

Articles

The star-critical Ramsey number r∗(H1, H2) is the smallest integer k such that every red/blue coloring of the edges of Kn − K1,n−k−1 contains either a red copy of H1 or a blue copy of H2, where n is the graph Ramsey number R(H1, H2). We study the cases of r∗(C4, Cn) and R(C4, Wn). In particular, we prove that r∗(C4, Cn) = 5 for all n > 4, obtain a general characterization of Ramsey-critical (C4, Wn)-graphs, and establish the exact values of R(C4, Wn) for 9 cases of n between 18 and 44.

On Mikhailov's Reduction Group, Tihomir Valchev

Articles

We present a generalization of the notion of reduction group which allows one to study in a uniform way certain classes of nonlocal $S$-integrable equations like Ablowitz-Musslimani's nonlocal Schr\"odinger equation. Another aspect of the proposed generalization is the possibility to derive in a systematic way solutions to S-integrable equations with prescribed symmetries.

Raman Micro Spectroscopy For In Vitro Drug Screening: Subcellular Localisation And Interactions Of Doxorubicin, Zeineb Farhane, Franck Bonnier, Alan Casey, Hugh Byrne

Articles

Vibrational spectroscopy, including Raman spectroscopy, has been widely used over the last few years to explore potential biomedical applications. Indeed, Raman spectroscopy has been demonstrated to be a powerful non-invasive tool in cancer diagnosis and monitoring. In confocal microscopic mode, the technique is also a molecularly specific analytical tool with optical resolution which has potential applications in subcellular analysis of biochemical processes, and therefore as an in vitro screening tool of the efficacy and mode of action of, for example, chemotherapeutic agents.

In order to demonstrate and explore the potential in this field, established, model chemotherapeutic agents can be valuable. …

Jewish Games For Learning: Renewing Heritage Traditions In The Digital Age, Owen Gottlieb

Articles

Rather than a discontinuity from traditional modes of learning, new explorations of digital and strategic games in Jewish learning are markedly continuous with ancient practices. An explication of the close connections between traditional modes of Jewish learning, interpretive practice, and gaming culture can help to explain how Jews of the Digital Age can adopt and are adapting modern Games for Learning practices for contemporary purposes. The chapter opens by contextualizing a notion of Jewish Games and the field of Games for Learning. Next, the chapter explains the connections between game systems and Jewish traditions. It closes with a case study …