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Suppressed Intuitions, Large Number Coincidences, And A Mathematical Foundation For Life And Consciousness, Maurice Goodman

Articles

A brief examination of the natural sciences reveals that we are still under the influence of pre Copernican intuitions. These have only been suppresses and not supplanted. This is why we appeal to such things as large number coincidences in the hope that the mathematics, which unlike us does not suffer from naive beliefs, will lead us in the right direction. However, we need to be extremely careful as it is easy to create these coincidences and over interpret their significance. In the 1980’s work on these coincidences did lead to a mathematical formulism which seems to have relevance in …

Biofilm Microbial Community Structure In An Urban Lake Utilizing Reclaimed Water, Tianzhi Wang, Yunkai Li, Tingwu Xu, Naiyang Wu, Mingchao Liang, Paul Hynds

Articles

Analyses of biofilm community structure may potentially be employed for aquatic ecosystem health assessment, however, to date, biofilm diversity within urban lakes using reclaimed water has not been examined. Accordingly, the microbial community diversity and structure of biofilms from the surface of multiple matrices with varying roughness (0.1, 1.0 and 10.0 μm) were characterized using a suite of molecular techniques including scanning electron microscopy, genetic fingerprinting and phospholipid-derived fatty acid analyses. Samples were largely comprised of inorganic particles, algae and numerous bacterial species; 12 phospholipid-derived fatty acid (PLFA) types were identified, significantly less than typically associated with sewage. Both growth …

Resolving The Policy Paradox: The Case Of Biofuel Production In Ireland, Alan Gilmer, Mark J. Mcgarrity, Vivienne Byers

Articles

Purpose – The purpose of this paper is to determine the status of policy design and policy implementation in the biofuel sector in Ireland. The focus of the work addresses the overarching operational context of the biofuel sector in Ireland and the role of different actors in shaping and resolving inconsistencies in policy outlook and practice. Design/methodology/approach – This study used a qualitative research approach involving a series of semi-structured interviews with members of the relevant sub-groups concerned. This study sought to address two questions – whether current or proposed policy is likely to affect consumption of indigenous biofuel feedstocks …

Predicting Asthma Exacerbations Employing Remotely Monitored Adherence, Isabelle Killane, Imran Sulaiman, Elaine Mac Hale, Aoife Breathnach, Terrence Taylor, Martin Holmes, Richard B Reilly, Richard W Costello

Articles

This Letter investigated the efficacy of a decision-support system, designed for respiratory medicine, at predicting asthma exacerbations in a multi-site longitudinal randomised control trial. Adherence to inhaler medication was acquired over 3 months from patients with asthma employing a dose counter and a remote monitoring adherence device which recorded participant's inhaler use: n = 184 (23,656 audio files), 61% women, age (mean ± sd) 49.3 ± 16.4. Data on occurrence of exacerbations was collected at three clinical visits, 1 month apart. The relative risk of an asthma exacerbation for those with good and poor adherence was examined employing a univariate …

Controlling Microbial Safety Challenges Of Meat Using High Voltage Atmospheric Cold Plasma, Lu Han, Dana Ziuzina, Caitlin Marie Heslin, Daniela Boehm, Apurva Patange, David Millan-Sango, Vasilis Valdramidis, Patrick J. Cullen, Paula Bourke

Articles

Atmospheric cold plasma (ACP) is a non-thermal technology, effective against a wide range of pathogenic microorganisms. Inactivation efficacy results from plasma generated reactive species. These may interact with any organic components in a test matrix including the target microorganism, thus food components may exert a protective effect against the antimicrobial mode of action. The effect of an in-package high voltage ACP process applied in conjunction with common meat processing MAP gas compositions as well as bacteria type and meat model media composition have been investigated to determine the applicability of this technology for decontamination of safety challenges associated with meat …

Environmental Influences On Elite Sport Athletes Well Being: From Gold, Silver, And Bronze To Blue Green And Gold, Aoife Donnelly, Tadhg Macintyre, Nollaig O'Sullivan, Giles Warrington, Andrew Harrison, Eric Igou, Marc Jones, Chris Gidlow, Noel Brick, Ian Lahart, Andrew Lane

Articles

This paper considers the environmental impact on well-being and performance in elite athletes during Olympic competition. The benefits of exercising in natural environments are recognized, but less is known about the effects on performance and health in elite athletes. Although some Olympic events take place in natural environments, the majority occur in the host city, usually a large densely populated area where low exposure to natural environments is compounded by exposure to high levels of air, water, and noise pollution in the ambient environment. By combining methods and expertise from diverse but inter-related disciplines including environmental psychology, exercise physiology, biomechanics, …

Human Factors At The Core Of Total Safety Management: The Need To Establish A Common Operational Picture, Maria Chiara Leva, Tom Kontogiannis, Nora Balfe, Micaela Demichela, Emmanuel Plot

Articles

The Total Operations Management for Safety Critical Activities (TOSCA) project is aimed at developing a safety management framework that integrates best practices, tools and methods for functional analysis, risk assessment, interactive emergency scenarios analysis, performance monitoring, design review, training and knowledge management. The TOSCA approach is described by a T-model based around a central ‘Common Operational Picture’ (COP) that holds information regarding the operational system, and is used to support risk assessment and management. The information held in the COP may be represented in different ways but should be accessible to all stakeholders in order to analyse and communicate risk, …

Cytotoxic And Mutagenic Potential Of Solutions Exposed To Cold Atmospheric Plasma, Daniela Boehm, Caitlin Heslin, P.J. Cullen, Paula Bourke

Articles

The exposure of aqueous solutions to atmospheric plasmas results in the generation of relatively long-lived secondary products such as hydrogen peroxide which are biologically active and have demonstrated anti-microbial and cytotoxic activity. The use of plasma-activated solutions in applications such as microbial decontamination or anti-cancer treatments requires not only adequate performance on target cells but also a safe operating window regarding the impact on surrounding tissues. Furthermore the generation of plasma-activated fluids needs to be considered as a by-stander effect of subjecting tissue to plasma discharges. Cytotoxicity and mutagenicity assays using mammalian cell lines were used to elucidate the effects …

Characterization Of Dielectric Barrier Discharge Atmospheric Air Plasma Treated Chitosan Films, Shashi Pankaj, Carmen Bueno-Ferrer, Luke O'Neill, B.K. Tiwari, Paula Bourke, Patrick J. Cullen

Articles

Dielectric barrier discharge (DBD) plasma is a novel non-thermal food decontamination technology. The effects of DBD plasma on the surface topography, chemical composition and crystal structure, film hydrophilicity, water vapor permeability and oxygen permeability of chitosan films have been examined. DBD plasma treatment increased the surface roughness of chitosan films with emergence of sharp protuberances. X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy spectra confirm a significant increase in the oxygen containing groups in the chitosan film after plasma treatment. Significant increase in the film hydrophilicity was observed after plasma treatment. X-ray diffraction results showed that DBD plasma treatment do …

Evaluation Of Plasma, High-Pressure And Ultrasound Processing On The Stability Of Fructooligosaccharides, Elenilson Alves Filho, Patrick J. Cullen, Jesus Maria Frias, Paula Bourke, Brijesh Tiwari, Edy Brito, Sueli Rodrigues, Fabiano Fernandes

Articles

Fructooligosaccharides (FOS) are among the main carbohydrates with prebiotic activity, and they are the most applied functional carbohydrate ingredient in the food industry. FOS are known to hydrolyse when subjected to thermal processing, thus partially losing its functional properties. In this study, we evaluate whether three nonthermal technologies are suitable for processing FOS regarding its stability after processing. FOS were subjected to ultrasound, high-pressure processing (HPP) and atmospheric cold plasma (ACP). The FOS solution, 70 g L−1, was set at a concentration recommended for human intake. The treatments were carried out at operating conditions usually used for microbial inactivation in …

Artemisinin Production By Plant Hairy Root Cultures In Gas- And Liquid-Phase Bioreactors, Nivedita Patra, Ashok K. Srivastava

Articles

Key message

Alternative biotechnological protocol for large-scale artemisinin production was established. It featured enhanced growth and artemisinin production by cultivation of hairy roots in nutrient mist bioreactor (NMB) coupled with novel cultivation strategies.

Artemisinin is used for the treatment of cerebral malaria. Presently, its main source is from seasonal plant Artemisia annua. This study featured investigation of growth and artemisinin production by A. annua hairy roots (induced by Agrobacterium rhizogenes-mediated genetic transformation of explants) in three bioreactor configurations—bubble column reactor, NMB and modified NMB particularly to establish their suitability for commercial production. It was observed that cultivation of …

The Neural Dynamics Of Somatosensory Processing And Adaptation Across Childhood: A High-Density Electrical Mapping Study, Neha Uppal, John J. Foxe, John Butler, Frantzy Acluche, Sophie Molholm

Articles

Young children are often hyperreactive to somatosensory inputs hardly noticed by adults, as exemplified by irritation to seams or labels in clothing. The neurodevelopmental mechanisms underlying changes in sensory reactivity are not well understood. Based on the idea that neurodevelopmental changes in somatosensory processing and/or changes in sensory adaptation might underlie developmental differences in somatosensory reactivity, high-density electroencephalography was used to examine how the nervous system responds and adapts to repeated vibrotactile stimulation over childhood. Participants aged 6–18 yr old were presented with 50-ms vibrotactile stimuli to the right wrist over the median nerve at 5 blocked interstimulus intervals (ranging …

Relationship Between Individualized Training Impulse And Aerobic Fitness Measures In Hurling Players Across A Training Period, Shane Malone, Kieran Collins

Articles

The current study examined the association between individual internal training load (individualized training impulse, iTRIMP) and aerobic fitness variables in male hurling players. Twenty hurling players (age, 25.5 ± 3.2 years; height, 178.9 ± 3.2 cm; body mass, 78.5 ± 4.5 kg) performed treadmill testing for V[Combining Dot Above]O2max, running economy (RE), and the speed at blood lactate concentrations of 2 mmol·L (S2) and 4 mmol·L (S4) on separate occasions before and after an 8-week training period. The Yo-Yo intermittent recovery (Yo-YoIR1, Yo-YoIR2) test performance were also assessed before and after the training period. Individualized training impulse was calculated using …

Energy-Saving Occupant Behaviour In Offices: Change Strategies, Mark Mulville, Keith Jones, Gesche Huebner, Joanne Powell-Grieg

Articles

As regulated energy consumption in buildings is reduced, the proportional importance of unregulated energy consumption increases. Reducing unregulated energy use in the commercial office requires an understanding of the factors that influence workplace behaviour. To date these factors have been assumed to be similar to those that influence behaviour in the home. However, the social dynamics of the workplace are different to those in the home. This study examines the degree to which theories of behaviour change generated largely in a domestic building setting could be used as the basis for designing interventions to reduce unregulated energy consumption in the …

Interactive Learning: Developing An Esimulation Portal Framework, Ayman Tobail, John Crowe, Amr Arisha

Articles

The emerging eLearning paradigm is becoming increasingly used in many academic disciplines. The concept acknowledges learning processes that no longer deploy only traditional teaching methods. It can be argued that today’s third level education students are part of a new virtual era where the blackboard has been replaced by the interactive whiteboard, so more interactive and virtually orientated teaching aids are required to assist in the transition from traditional learning to eLearning. The key objective of this paper is to propose a simulation-based learning framework that integrates web-based simulation and a web content management hierarchy model. Using the highly complex …

The Acute:Chonic Workload Ratio In Relation To Injury Risk In Professional Soccer, Shane Malone, Adam Owen, Matt Newton, Bruno Mendes, Kieran Collins, Tim Gabbett

Articles

Forty-eight professional soccer players (mean ± SD age of 25.3 ± 3.1 yr) from two elite European teams were involved within a one season study. Players completed a test of intermittent-aerobic capacity (Yo-YoIR1) to assess player’s injury risk in relation to intermittent aerobic capacity. Weekly workload measures and time loss injuries were recorded during the entire period. Rolling weekly sums and week-to-week changes in workload were measured, allowing for the calculation of the acute:chronic workload ratio, which was calculated by dividing the acute (1-weekly) and chronic (4-weekly) workloads. All derived workload measures were modelled against injury data using logistic regression. …

The Integration Of Internal And External Training Load Metrics In Hurling, Shane Malone, Dominic Doran, Ibrahim Akubat Ibrahim Akubat, Kieran Collins

Articles

The current study aimed to assess the relationship between the hurling player’s fitness profile and integrated training load (TL) metrics. Twenty-five hurling players performed treadmill testing for VO2max, the speed at blood lactate concentrations of 2 mmol•L-1 (vLT) and 4 mmol•L-1 (vOBLA) and the heart rate-blood lactate profile for calculation of individual training impulse (iTRIMP). The total distance (TD; m), high speed distance (HSD; m) and sprint distance (SD; m) covered were measured using GPS technology (4-Hz, VX Sport, Lower Hutt, New Zealand) which allowed for the measurement of the external TL. The external TL was divided by the internal …

Linocin And Ompw Are Involved In Attachment Of The Cystic Fibrosis-Associated Pathogen Burkholderia Cepacia Complex To Lung Epithelial Cells And Protect Mice Against Infection, Siobhan Mcclean, Marc Healy, Cassandra Collins, Stephen Carberry, Luke O'Shaughnessy, Ruth Dennehy, Aine Adams Aine Adams, Helen Kennelly, Jennifer Corbett, Fiona Carty, Laura Ann Cahill, Máire Callaghan, Karen English, Bernard P. Mahon, Sean Doyle, Minu Shinoy

Articles

Burkholderia cepacia complex (Bcc) causes chronic opportunistic lung infections in people with cystic fibrosis (CF) resulting in a gradual lung function decline and, ultimately, patient death. Bcc is a complex of eighteen species and is rarely eradicated once a patient is colonised, therefore vaccination may represent a better therapeutic option. We developed a new proteomics approach to identify bacterial proteins that are involved in attachment of Bcc to lung epithelial cells. Fourteen proteins were reproducibly identified by 2-DE from four Bcc strains, representative of two Bcc species: B. cenocepacia, the most virulent and B. multivorans, the most frequently acquired. Seven …

Injury Scheme Claims In Gaelic Games: A Review Of 2007-2014, Mark Roe, Catherine Blake, Conor Gissane, Kieran Collins

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Context: Gaelic games (Gaelic football and hurling) are indigenous Irish sports with increasing global participation in recent years. Limited information is available on longitudinal injury trends. Reviews of insurance claims can reveal the economic burden of injury and guide cost-effective injury-prevention programs.

Iron Acquisition In The Cystic Fibrosis Lung And Potential For Novel Therapeutic Strategies, Jean Tyrrell, Máire Callaghan

Articles

Iron acquisition is vital to microbial survival and is implicated in the virulence of many of the pathogens that reside in the cystic fibrosis (CF) lung. The multifaceted nature of iron acquisition by both bacterial and fungal pathogens encompasses a range of conserved and species-specific mechanisms, including secretion of iron-binding siderophores, utilization of siderophores from other species, release of iron from host iron-binding proteins and haemoproteins, and ferrous iron uptake. Pathogens adapt and deploy specific systems depending on iron availability, bioavailability of the iron pool, stage of infection and presence of competing pathogens. Understanding the dynamics of pathogen iron acquisition …

Effects Of Various Concentrations Of Carbohydrate Mouth Rinse On Cycling Performance In A Fed State, Simon Devenney, Kieran Collins, Marcus Shortall

Articles

The objective of this study was to identify the effects of mouth rinsing with a 6% and 16% carbohydrate solution (CHO) on time trial performance when compared to a 0% control (PLA) when in a fed state. Twelve recreationally active males underwent three trials by which they had to complete a set workload (600 ± 65 W) in a fed state. Throughout each trial, participants rinsed their mouths with a 25 ml bolus of a 0% PLA, 6% or 16% CHO (maltodextrin) for every 12.5% of work completed. Rating of perceived exertion (RPE) and heart rate were recorded every 12.5% …

The Running Performance And Estimated Energy Cost Of Hurling Specific Small-Sided Games, Shane Malone, Kieran Collins, Dominic Doran

Articles

The current study examined the extent to which pitch dimensions can influence the physical and estimated energetic demands of hurling small-sided games. Training data (n = 990) were collected from 24 (age 25.5 ± 3.2 years; height 178.9 ± 3.2 cm; body mass 78.5 ± 4.5 kg) hurling players using 4-Hz global positioning system technology (VX Sport, Lower Hutt, New Zealand). Total distance (m), high-speed running distance (m; ≥ 17 km/h), very high-speed running distance (m; ≥ 22 km/h), total accelerations (n), acceleration distance (m), peak and mean velocity (km/h) were considered. In addition changes in velocity …

Yo-Yo Intermittent Recovery Test Performance In Subelite Gaelic Football Players From Under Thirteen To Senior Age Groups, Mark Roe, Shane Malone

Articles

Gaelic football is indigenous to Ireland and has similar locomotion profiles to soccer and Australian Football. Given the increasing attention on long-term player development, investigations into age-related variation in Yo-YoIR1 performance may provide useful information in talent identification, programme design, and player monitoring. Therefore, the aim of this study was to evaluate Yo-YoIR1 performance across Gaelic football age groups. Male participants (n = 355) were recruited from division one, Gaelic football teams. Participants were allocated to one of seven groups according to respective age groups from under 13 (U13), under 14, under 15 (U15), under 16 (U16), minor, under 21 …

Current And Emerging Therapies For The Treatment Of Cystic Fibrosis Or Mitigation Of Its Symptoms, Mark P. Murphy, Emma M. Caraher

Articles

Clinical presentation of the chronic, heritable condition cystic fibrosis (CF) is complex, with a diverse range of symptoms often affecting multiple organs with varying severity. The primary source of morbidity and mortality is due to progressive destruction of the airways attributable to chronic inflammation arising from microbial colonisation. Antimicrobial therapy combined with practises to remove obstructive mucopurulent deposits form the cornerstone of current therapy. However, new treatment options are emerging which offer, for the first time, the opportunity to effect remission from the underlying cause of CF. Here, we discuss these therapies, their mechanisms of action, and their successes and …

An Analysis Of Folic Acid Supplementation In Women Presenting For Antenatal Care, Shona Cawley, Laura Mullaney, Aoife Mckeating, Maria Farren, Daniel Mccartney, Michael Turner

Articles

Background: Neural tube defects (NTDs) are major congenital malformations that are potentially preventable if the woman takes periconceptional folic acid (FA) supplements. A recent report found that NTD incidence had increased in Ireland. This study examined the usage of FA supplementation in women presenting for antenatal care in a maternity hospital.

A New Educational Mobile Devices Platform For Social Inclusion In Tanzania, Fredrick Mtenzi

Articles

Abstract— It is evident that advances in technology has led to improvement in societal wellbeing. In this paper we demonstrate how mobile phones are used in providing reliable and quality education to students in disadvantaged areas of Tanzania. The main contribution is on leveraging on the success that Tanzania has had on using mobile banking to the un-banked population. These lessons are adapted to the education sector, where clever/smart integration of existing disruptive technologies such as mobile phones and social networks are be used to provide access to high quality educational contents. Further, the paper shows how educational content can …

Overview Of Fiber Optic Sensor Technologies For Strain/Temperature Sensing Applications In Composite Materials, Manjusha Ramakrishnan, Ginu Rajan, Yuliya Semenova, Gerald Farrell

Articles

This paper provides an overview of the different types of fiber optic sensors (FOS) that can be used with composite materials and also their compatibility with and suitability for embedding inside a composite material. An overview of the different types of FOS used for strain/temperature sensing in composite materials is presented. Recent trends, and future challenges for FOS technology for condition monitoring in smart composite materials are also discussed. This comprehensive review provides essential information for the smart materials industry in selecting of appropriate types of FOS in accordance with end-user requirements.

Long-Term Drainage Reduces Co2 Uptake And Increases Co2 Emission On A Siberian Floodplain Due To Shifts In Vegetation Community And Soil Thermal Characteristics, Min Jung Kwon, Martin Heimann, Olaf Kolle, Kristina Luus, Edward A. G. Schuur, Nikita Zimov, Sergey A. Zimov, Mathias Göckede

Articles

Abstract. With increasing air temperatures and changing precipitation patterns forecast for the Arctic over the coming decades, the thawing of ice-rich permafrost is expected to increasingly alter hydrological conditions by creating mosaics of wetter and drier areas. The objective of this study is to investigate how 10 years of lowered water table depths of wet floodplain ecosystems would affect CO2 fluxes measured using a closed chamber system, focusing on the role of long-term changes in soil thermal characteristics and vegetation community structure. Drainage diminishes the heat capacity and thermal conductivity of organic soil, leading to warmer soil temperatures in shallow …

Transparency And The Supreme Court—Can Employers Refuse To Disclose How Much They Pay For Health Care?, Nicholas Bagley, Christopher Koller

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For decades, the prices that hospitals and physicians charge private insurers have been treated as trade secrets. Even though inflated prices are an enormous reason why health care is so much more expensive in the United States than in other countries, we have only a hazy picture of what those prices actually are.

Tbx2 Represses Pten In Rhabdomyosarcoma And Skeletal Muscle., B Zhu, M Zhang, E M Williams, C Keller, A Mansoor, J K Davie

Articles

Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children that shares many features of developing skeletal muscle. TBX2, a T-box family member, is highly upregulated in tumor cells of both major RMS subtypes where it functions as an oncogene. TBX2 is a repressor that is often overexpressed in cancer cells and functions in bypassing cell growth control, including the repression of the cell cycle regulators p14 and p21. We have found that TBX2 directly represses the tumor-suppressor phosphatase and tensin homolog (PTEN) in both RMS and normal muscle. Exogenous expression of TBX2 in normal muscle cells downregulates PTEN, …