Digital Commons Network^™

An Enhanced Spring-Particle Model For Red Blood Cell Structural Mechanics: Application To The Stomatocyte–Discocyte– Echinocyte Transformation, Mingzhu Chen, Fergal Boyle

Articles

Red blood cells (RBCs) are the most abundant cellular element suspended in blood. Together with the usual biconcave-shaped RBCs, i.e., discocytes, unusual-shaped RBCs are also observed under physiological and experimental conditions, e.g., stomatocytes and echinocytes. Stomatocytes and echinocytes are formed from discocytes and in addition can revert back to being discocytes; this shape change is known as the stomatocyte–discocyte–echinocyte (SDE) transformation. To-date, limited research has been conducted on the numerical prediction of the full SDE transformation. Spring- particle RBC (SP-RBC) models are commonly used to numerically predict RBC mechanics and rheology. However, these models are incapable of predicting the full …

The Potential Of Atmospheric Air Cold Plasma For Control Of Bacterial Contaminants Relevant To Cereal Grain Production, Agata Los, Dana Ziuzina, Daniela Boehm, Patrick J. Cullen, Paula Bourke

Articles

The aim of this work was to investigate the efficacy of dielectric barrier discharge atmospheric cold plasma (DBD ACP) against bacteria associated with grains quality and safety. ACP inactivation efficacy was tested against biofilms formed by different strains of E. coli, Bacillus and Lactobacillus in grain model media and against B. atrophaeus endospores either in grain media or attached on abiotic surfaces. Effects were dependent on bacterial strain, media composition and mode of ACP exposure. ACP treatment for 5min reduced E. coli spp., B. subtilis and Lactobacillus spp. biofilms by >3 log10, whereas insignificant reductions were achieved for B. atrophaeus. …

Industry Lobbying And "Interest Blind" Access Norms At International Organizations, Melissa J. Durkee

Articles

The standard approach of international organizations (IOs) makes no formal distinctions between nonprofit private sector associations, known as trade or industry groups, and public interest groups like Amnesty International or Greenpeace. After all, these groups are all organized as nonprofits; they may all be characterized as nongovernmental organizations representing the interests of their memberships; and the groups all seek to advance the agendas of members by offering ideas and expertise to international officials or bodies—classic lobbying activity. Thus, most IOs offer accreditation and access to both private sector and public interest groups on equal terms, without differentiating between them. I …

Justice Visualized: Courts And The Body Camera Revolution, Mary D. Fan

Articles

What really happened? For centuries, courts have been magisterially blind, cloistered far away from the contested events that they adjudicate, relying primarily on testimony to get the story—or competing stories. Whether oral or written, this testimony is profoundly human, with all the passions, partisanship and imperfections of human perception.

Now a revolution is coming. Across the nation, police departments are deploying body cameras. Analyzing body camera policies from police departments across the nation, the article reveals an unfolding future where much of the main staple events of criminal procedure law will be recorded. Much of the current focus is on …

The Vested Rights Doctrine: How A Shield Against Injustice Became A Sword For Opportunistic Developers, Steve P. Calandrillo, Chryssa Deliganis, Christina Elles

Articles

In an era of pioneering environmental and land use laws, savvy developers are using the “vested rights” doctrine to circumvent and undermine critical public health, safety, and environmental regulations. This controversy pits two legitimate interests against each other: On the one hand, local governments must have the power to pass land use laws and regulations in the public interest to protect their community’s health, safety, welfare, and environment. On the other, developers who rely on the laws in existence at the time their project is approved should be protected from subsequent changes to the law that could increase transactional costs …

Standards Of Review In Law And Sports: How Instant Replay's Asymmetric Burdens Subvert Accuracy And Justice, Steve P. Calandrillo, Joseph Davison

Articles

A fundamental tension exists in both law and sports: on one hand, adjudicators must “get the decision right” in order to provide fairness to the parties involved, but on the other, they must issue speedy and certain rulings to avoid delaying justice. The certainty principle dictates that courts follow stare decisis in the law even if they believe that an earlier decision was wrong. However, it is often the case that there is a need to reverse earlier decisions or the law itself in order to make the correct call on appeal.

Both law and sports are constantly balancing the …

Regulating Cumulative Risk, Sanne H. Knudsen

Articles

This Article proceeds in four parts. Part I describes how cumulative risk assessments tackle the real-world exposure problems that lie at the heart of public health. It shows how risk science has evolved and why policy, not science, lags behind. Part II then examines why key public health concerns cannot be answered through information disclosure or consumer choice models alone.

Having established that regulatory drivers are needed, Part III begins to examine how to move forward. It does so by looking backward and examining how TSCA and FIFRA have failed historically to provide this critical public health focus despite room …

Quantification Of Rubidium As A Trace Element In Beef Using Laser Induced Breakdown Spectroscopy, Yash Dixit, Maria Piedad Casado-Gavalda, Raquel Cama-Moncunill, Xavier Cama-Moncunill, Patrick J. Cullen, Carl Sullivan

Articles

This study evaluates the potential of laser induced breakdown spectroscopy (LIBS) coupled with chemometrics to develop a quantification model for rubidium (Rb) in minced beef. A LIBSCAN 150 system was used to collect LIBS spectra of minced beef samples. Beef liver was used to spike the Rb levels in minced beef. All samples were dried, powdered and pelleted using a hydraulic press. Measurements were conducted by scanning 100 different locations with an automated XYZ sample chamber. Partial least squares regression (PLSR) was used to develop the calibration model, yielding a calibration coefficient of determination (Rc2) of 0.99 and a root …

Facilitating Smart Haccp Strategies With Process Analytical Technology, Fintan Moran, Carl Sullivan, Kevin Keener, Patrick J. Cullen

Articles

The critical feature to any food management system, be it safety or quality focused, is timely and accurate product and process data. The HACCP framework is one of a systematic preventive approach that addresses hazards as a means of prevention rather than finished product inspection. The PAT initiative is a framework which also aims to change product assurance from end-product testing to preventive control through timely measurements of critical product and process parameters. The continued emergence of sensitive yet affordable sensors capable of direct measurement of biological, chemical and physical risks associated with foods during production, processing or over their …

Preferences Of Women For Web-Based Nutritional Information In Pregnancy, Rachel Ak Kennedy, Laura Mullaney, C.M.E. Reynolds, Shona Cawley, Daniel Mccartney, M.J. Turner

Articles

Objectives During pregnancy, women are increasingly turning to web-based resources for information. This study examined the use of web-based nutritional information by women during pregnancy and explored their preferences. Study design Cross-sectional observational study. Methods Women were enrolled at their convenience from a large maternity hospital. Clinical and sociodemographic details were collected and women's use of web-based resources was assessed using a detailed questionnaire. Results Of the 101 women, 41.6% were nulliparous and the mean age was 33.1 years (19–47 years). All women had internet access and only 3% did not own a smartphone. Women derived pregnancy-related nutritional information from …

Assessment Of Mental Workload: A Comparison Of Machine Learning Methods And Subjective Assessment Techniques, Karim Moustafa, Saturnino Luz, Luca Longo

Articles

Mental workload (MWL) measurement is a complex multidisciplinary research field. In the last 50 years of research endeavour, MWL measurement has mainly produced theory-driven models. Some of the reasons for justifying this trend includes the omnipresent uncertainty about how to define the construct of MWL and the limited use of datadriven research methodologies. This work presents novel research focused on the investigation of the capability of a selection of supervised Machine Learning (ML) classification techniques to produce data-driven computational models of MWL for the prediction of objective performance. These are then compared to two state-of-the-art subjective techniques for the assessment …

Improved Protocols For Pre-Processing Raman Spectra Of Formalin Fixed Paraffin Preserved Tissue Sections, Hugh Byrne, Fiona Lyng, Ola Ibrahim, Adrian Maguire, Aidan Meade, Steven Flint, M. Toner

Articles

Although formalin fixed paraffin preserved (FFPP) tissues are a major resource for retrospective studies of disease progression, their use in vibrational spectroscopy studies has been undermined by issues of contributions of substrate and paraffin wax which persist in the spectra and can compromise spectral analysis. Recognising the microcrystalline nature of the wax in the tissue, which are inhomogeneously oriented with respect to the polarisation of the Raman source laser, in this study, we have developed a novel method for removing the paraffin wax contributions to the spectra using matrices of multiple wax spectra. FFPP tissue sections from the oral mucosa …

Development Of Methodology For Raman Microspectroscopic Analysis Of Oral Exfoliated Cells, Hugh Byrne, Fiona Lyng, Alison Malkin, Ola Ibrahim, Genecy Calado, Steven Flint, Isha Behl

Articles

Oral squamous cell carcinoma ranks as the 15th most common cancer worldwide. The present study was undertaken to standardise a protocol for the analysis of oral exfoliated cells using Raman microspectroscopy. For this purpose, samples were obtained from two different sites, based on prevalence of disease (ventral side of the tongue and buccal mucosa). Different oral rinsing agents were employed and it was concluded that non-alcoholic mouthwash adequately removes food debris. Samples were collected using various collection tools and compared. It was observed that endo-cervical brushes yielded cells from deeper layers of the epithelium. Furthermore, monolayer formation of cells was …

Heat Wave And Mortality: A Multicountry, Multicommunitystudy, Y. Guo, A. Gasparrini, B.G. Armstrong, B Tawatsupa, A. Tobias, E. Lavinge, M. De Sousa Zanotti Stagliorio Coelho, X. Pan, H. Kim, M. Hashizume, Y. Honda, Y. Leon Guo, C. Wu, A. Zanobetti, J. D. Schwartz, M. L. Bell, M. Scortichini, P. Michelozzi, K. Punnasiri, S. Li, L. Tian, S. D. Osorio Garcia, X. Seposo, A. Overcenco, A. Zeka, P. J. Goodman, T. N. Dang, D. V. Dung, F. Mayvaneh, P. H. Nascimento Saldiva, G. Williams, S. Tong

Articles

Heat waves of all definitions had significant cumulative associations with mortality in all countries, but varied by community. The higher the temperature threshold used to define heat waves, the higher heat wave associations on mortality. However, heat wave duration did not modify the impacts. The association between heat waves and mortality appeared acutely and lasted for 3 and 4 d. Heat waves had higher associations with mortality in moderate cold and moderate hot areas than cold and hot areas. There were no added effects of heat waves on mortality in all countries/regions, except for Brazil, Moldova, and Taiwan. Heat waves …

Pilot Evaluation Of An Online Weight Management Programme, Shona Cawley, S. Farrell, D. G. Byrne, M. J. Turner, B. Clune, Daniel Mccartney

Articles

This intervention examined the efficacy of a six-week online weight loss programme. Student and staff of a third level institution (n=183) were recruited to the programme which provided individualised dietary advice for weight loss. Eighty-five participants (mean age 29.7 years, mean BMI 28.9kg/m2, 33% male) met the minimum inclusion criterion of logging on to the study website at least twice.

Controlled Cytotoxicity Of Plasma Treated Water Formulated By Open-Air Hybrid Mode Discharge, Peng Lu, Daniela Boehm, Paula Bourke, Patrick J. Cullen

Articles

Plasma‐activated liquids (PAL) attract increasing interest with demonstrated biological effects. Plasma exposure in air produces stable aqueous reactive species which can serve as chemical diagnostics of PAL systems. Here, we tailor aqueous reactive species inside plasma‐activated water (PAW) through treating water with AC air spark and glow discharges in contact with water. Chemical probing demonstrated species specificity between two types of PAW. Spark discharge PAW contains urn:x-wiley:14381656:media:ppap201600207:ppap201600207-math-0006 and urn:x-wiley:14381656:media:ppap201600207:ppap201600207-math-0007, while urn:x-wiley:14381656:media:ppap201600207:ppap201600207-math-0008and urn:x-wiley:14381656:media:ppap201600207:ppap201600207-math-0009 are generated in glow discharge PAW. Species formation in different PAWs have been discussed in terms of discharge mechanisms and liquid phase chemistry process. Species specificity can provide …

Exploring Smoking, Mental Health And Smoking-Related Disease In A Nationally Representative Sample Of Older Adults In Ireland: A Retrospective Secondary Analysis, Annette Burns, Judith Strawbridge, Luke Clancy, Frank Doyle

Articles

Objective

Smoking is the leading preventable cause of death among individuals with mental health difficulties (MHD). The aim of the current study was to determine the impact of smoking on the physical health of older adults with MHD in Ireland and to explore the extent to which smoking mediated or moderated associations between MHD and smoking-related diseases.

Methods

Cross-sectional analysis of a nationally representative sample of 8175 community-dwelling adults aged 50 and over from The Irish Longitudinal Study on Ageing (TILDA) was undertaken. Multivariate adjusted logistic regression models were used to assess the association between MHD, smoking (current/past/never) and smoking-related …

Sarcopenia: Prevalence, And Impact On Operative And Oncologic Outcomes In The Multimodal Management Of Locally Advanced Esophageal Cancer, Jessie Elliott, Suzanne Doyle, Conor Murphy, Sinead King, Emer Guinan, Peter Beddy, Narayanasamy Ravi, John Reynolds

Articles

Objective: The aim of this article was to study the prevalence and significance of sarcopenia in the multimodal management of locally advanced esophageal cancer (LAEC), and to assess its independent impact on operative and oncologic outcomes.

Summary of background data: Sarcopenia in cancer may confer negative outcomes, but its prevalence and impact on modern multimodal regimens for LAEC have not been systematically studied.

Methods: Two hundred fifty-two consecutive patients were studied. Lean body mass (LBM), skeletal muscle index (SMI), and fat mass (FM) were determined pre-treatment, preoperatively, and 1 year postoperatively. Sarcopenia was defined by computed tomography (CT) at L3 …

Raman Spectroscopy For Cytopathology Of Exfoliated Cervical Cells, Fiona Lyng, Ir Ramos, Aidan Meade, O. Ibrahim, M. Mcmenamin, M. Mckenna, A. Malkin

Articles

No abstract provided.

The Nature Of Sequential Innovation, Christopher Buccafusco, Stefan Bechtold, Christopher Jon Sprigman

Articles

When creators and innovators take up a new task, they face a world of existing creative works, inventions, and ideas, some of which are governed by intellectual property (IP) rights. This presents a choice: Should the creator pay to license those rights? Or, alternatively, should the creator undertake to innovate around them? Our Article formulates this “build on/build around decision” as the fundamental feature of sequential creativity, and it maps a number of factors—some legal, some contextual—that affect how creators are likely to decide between building on existing IP or building around it. Importantly, creators are influenced by more than …

How Strange The Change From Major To Minor, Peter Goodrich

Articles

No abstract provided.

An Equal Rights Amendment For The Twenty-First Century: Bringing Global Constitutionalism Home, Julie C. Suk

Articles

The last few years have seen a renewed push to constitutionalize sex equality in the United States. A generation after the federal Equal Rights Amendment (ERA) failed to be ratified by the requisite number of states, the ERA is on the platform of the 2017 Women's March on Washington. Oregon added a sex equality guarantee to its state constitution in 2014, joining 22 state constitutions and most constitutions around the world. Feminist coalitions, Hollywood celebrities, and members of Congress are vocally endorsing an ERA revival. Why is an ERA desired now, when judges have interpreted the Fourteenth Amendment to prohibit …

Thermal Inactivation Analysis Of Water-Related Pathogens In Domestic Hot Water Systems, Liam Mccarton, Sean O'Hogain

Articles

This study aims to investigate whether hot water systems supplied with harvested rainwater present an increased risk to health over hot water systems supplied with potable mains water. It reviews previous studies investigating the health effects of utilising rainwater within domestic systems. The main risk to public health of mains-supplied hot water systems is the operation, maintenance, age, location and temperature of the system. Rainwater-harvesting systems contain an inherent water treatment train consisting of flocculation, settlement, sorption and bioreaction, and stored rainwater quality improves as metal and chemical contaminants settle to form sludge. Laboratory experiments were conducted using a variety …

Review: Epidemiological Evidence Of Groundwater Contribution To Global Enteric Disease, 1948–2015, Heather Murphy, Morgan Prioleau, Mark Borchardt, Paul Hynds

Articles

Globally, approximately 2.2 billion people rely on groundwater for daily consumption. It is widely accepted that groundwater is more pristine than surface water but while this assumption is frequently the case, groundwater is not ubiquitously free of contaminants; accordingly, this presumption can result in an unfounded and potentially hazardous sense of security among owners, operators and users. The current paper presents a review of published literature providing epidemiological evidence of the contribution of groundwater to global human enteric infection. An emphasis is placed on enteric pathogens transmitted via the faecal-oral route, and specifically those associated with acute gastrointestinal illness (AGI). …

Evaluation Of Levels Of Antibiotic Resistance In Groundwater-Derived E. Coli Isolates In The Midwest Of Ireland And Elucidation Of Potential Predictors Of Resistance, Jean O'Dwyer, Paul Hynds, Matthieu Pot, Catherine Adley, Michael Ryan

Articles

Antibiotic-resistant (pathogenic and non-pathogenic) organisms and genes are now acknowledged as significant emerging aquatic contaminants with potentially adverse human and ecological health impacts, and thus require monitoring. This study is the first to investigate levels of resistance among Irish groundwater (private wells) samples; Escherichia coli isolates were examined against a panel of commonly prescribed human and veterinary therapeutic antibiotics, followed by determination of the causative factors of resistance. Overall, 42 confirmed E. coli isolates were recovered from a groundwater-sampling cohort. Resistance to the human panel of antibiotics was moderate; nine (21.4%) E. coli isolates demonstrated resistance to one or more …

Geospatial Drivers Of The Groundwater Δ18o Isoscape In A Temperate Maritime Climate (Republic Of Ireland), S. Regan, R. Goodhue, O. Naughton, Paul Hynds

Articles

In recent years, the concept of “isoscapes” has been used to describe spatiotemporal stable isotope distributions within natural environments including groundwater systems at multiple scales. This study presents an updated groundwater δ18O isoscape for the Republic of Ireland and describes the climatic and geological drivers influencing 18O composition. In all, 142 geographically and geologically representative groundwater installations were sampled and analysed, in addition to 35 samples from six nested boreholes. Geospatially, Irish groundwater exhibits high δ18O values in southern and western coastal regions, becoming progressively depleted inland before reaching lowest measured values along the eastern coast, equating to a national …

An Overview Of Dissolved Organic Carbon In Groundwater And Implications For Drinking Water Safety, S. Regan, Paul Hynds, R. Flynn

Articles

Dissolved organic carbon (DOC) is composed of a diverse array of compounds, predominantly humic substances, and is a near ubiquitous component of natural groundwater, notwithstanding climatic extremes such as arid and hyper-arid settings. Despite being a frequently measured parameter of groundwater quality, the complexity of DOC composition and reaction behaviour means that links between concentration and human health risk are difficult to quantify and few examples are reported in the literature. Measured concentrations from natural/unpolluted groundwater are typically below 4 mg C/l, whilst concentrations above these levels generally indicate anthropogenic influences and/or contamination issues and can potentially compromise water safety. …

3d Printing Aids Acetabular Reconstruction In Complex Revision Hip Arthroplasty, Andrew J. Hughes, Cathal Debuitleir, Philip Soden, Brian O'Donnchada, Anthony Tansey, Ali Abdulkarim, Colm Mcmahon, Conor J. Hurson

Articles

Revision hip arthroplasty requires comprehensive appreciation of abnormal bony anatomy. Advances in radiology and manufacturing technology have made three-dimensional (3D) representation of osseous anatomy obtainable, which provide visual and tactile feedback. Such life-size 3D models were manufactured from computed tomography scans of three hip joints in two patients. The first patient had undergone multiple previous hip arthroplasties for bilateral hip infections, resulting in right-sided pelvic discontinuity and a severe left-sided posterosuperior acetabular deficiency. The second patient had a first-stage revision for infection and recurrent dislocations. Specific metal reduction protocols were used to reduce artefact. The images were imported into Materialise …

N-Isopropylacrylamide-Based Photopolymer For Holographic Recording Of Thermosensitive Transmission And Reflection Grating, Tatsiana Mikulchyk, Suzanne Martin, Izabela Naydenova

Articles

In recent years, functionalized photopolymer systems capable of holographic recording are in great demand due to their potential use in the development of holographic sensors. This work presents a newly developed Nisopropylacrylamide(NIPA)-based photopolymer for holographic recording in reflection and transmission modes. The optimized composition of the material is found to reach refractive index modulation of up to 5  10-3 and 1.6  10-3 after recording in transmission and reflection mode, respectively. In addition to fulfilling the requirements for holographic recording materials, the NIPA-based photopolymer is sensitive to temperature and has lower toxicity than acrylamide-based photopolymers. Possible application of the …

Humidity And Temperature Induced Changes In The Diffraction Efficiency And The Bragg Angle Of Slanted Photopolymer-Based Holographic Gratings, Tatsiana Mikulchyk, James Walshe, Dervil Cody, Suzanne Martin, Izabela Naydenova

Articles

This work explores the humidity and temperature response of volume phase slanted gratings recorded in photopolymers with varied chemical composition. Acrylamide and diacetone acrylamide were used as monomers and triethanolamine and N-phenylglycine were used as photoinitiators. The study demonstrates that the response of photopolymer-based holographic gratings to relative humidity (RH) and temperature (T) can be tuned by alteration of the photopolymer composition.Humidity and temperature response of the holograms has been characterized by recording Bragg selectivity curves of transmission gratings and by monitoring the position of the maximum intensity in the spectral response of reflection gratings. Investigation of the humidity response …