Digital Commons Network^™

Cold Atmospheric Plasma Induces Atp-Dependent Endocytosis Of Nanoparticles And Synergistic U373mg Cancer Cell Death, Zhonglei He, Kangze Liu, Eline Manaloto, Alan Casey, George P. Cribaro, Hugh Byrne, Furong Tian, Carlos Barcia, Gillian Conway, Patrick J. Cullen, James Curtin

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Gold nanoparticles (AuNP) have potential as both diagnostic and therapeutic vehicles. However, selective targeting and uptake in cancer cells remains challenging. Cold atmospheric plasma (CAP) can be combined with AuNP to achieve synergistic anti-cancer cytotoxicity. To explore synergistic mechanisms, we demonstrate both rate of AuNP uptake and total amount accumulated in U373MG Glioblastoma multiforme (GBM) cells are signifcantly increased when exposed to 75kV CAP generated by dielectric barrier discharge. No signifcant changes in the physical parameters of AuNP were caused by CAP but active transport mechanisms were stimulated in cells. Unlike many other biological efects of CAP, long-lived reactive species …

Preparation And Physical Properties Of Functional Barium Carbonate Nanostructures By A Facile Composite-Hydroxide-Mediated Route, Tauseef Shahid, Muhammad Arfan, Aurang Zeb, Tayyaba Bibi, Taj Muhammad Khan

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In recent years, nanotechnology has given birth to numerous nanomaterials due to their increased use in various sectors of research and development. To produce these nanomaterials, nanotechnology further has opened several rooms for the potential novel methods. Composite-hydroxide-mediated (CHM) method is one of the recent chemical synthesis routes that have gained considerable importance in research due to their effortlessness and versatile nature, covering a broad range of nanomaterials to prepare.

Interdisciplinary Teaching And Learning Within Molecular Gastronomy Education: Does It Benefit Students?, Roisin Burke, Pauline Danaher

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Since the creation of Molecular Gastronomy (MG) as a scientific discipline in 1988 a variety of higher education modules and programmes in that discipline have developed around the world. At the Technological University Dublin, MG has been taught using an interdisciplinary approach since the academic year 2012/2013. A Culinary Science lecturer and a Culinary Arts lecturer work in synergy and teach an interdisciplinary group of Food Science (FS) and Culinary Arts (CA) students. The students’ work is assessed, in each academic year, using summative methods i.e. written exam and a project assignment. In the academic year 2016/2017 the assignment reports …

The Living Anti-Injunction Act, Daniel Hemel

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No abstract provided.

Impact Of Supplemental Oxygen On Obstructive Sleep Apnea Of Infants, Piyush Das, R Kashyap, S Kotagal

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Abstract: Treatment options may be limited for infants with obstructive sleep apnea when there is no surgically correctable upper airway lesion. We therefore evaluated, retrospectively, the efficacy of low-flow oxygen as a therapeutic option for infant obstructive sleep apnea. We reviewed the medical charts of 23 infants who had undergone a therapeutic trial of low-flow oxygen during polysomnography. Split-night polysomnography was used in 21/23 subjects while 2/23 had undergone two separate, full-night polysomnography sleep architecture and respiratory findings on the baseline polysomnogram segment that was obtained in room air were compared with the segment on low-flow oxygen (0.25–1 L/min). Wilcoxon …

Courts’ Limited Ability To Protect Constitutional Rights, Adam S. Chilton, Mila Versteeg

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No abstract provided.

Using Intellectual Property Law To Promote Human Flourishing For Market Women, J. Janewa Osei-Tutu

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No abstract provided.

Are Medicaid Work Requirements Legal?, Nicholas Bagley

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On January 12, 2018, the Centers for Medicare & Medicaid Services (CMS) approved a waiver allowing Kentucky to impose a work requirement on some nondisabled Medicaid beneficiaries. Similar waivers are sure to follow. Supporters see work requirements as a spur to force the idle poor to work; opponents see the requirements as a covert means of withholding medical care from vulnerable people. Setting the policy debate aside, however, are work requirements legal?

Two Deans Answer The Law School Wellness Questions They Hear The Most, Janet Stearns, David B. Jaffe

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No abstract provided.

The Fortification Of Inequality: Constitutional Doctrine And The Political Economy, Kate Andrias

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As Parts I and II of this Essay elaborate, the examination yields three observations of relevance to constitutional law more generally: First, judge-made constitutional doctrine, though by no means the primary cause of rising inequality, has played an important role in reinforcing and exacerbating it. Judges have acquiesced to legislatively structured economic inequality, while also restricting the ability of legislatures to remedy it. Second, while economic inequality has become a cause célèbre only in the last few years, much of the constitutional doctrine that has contributed to its flourishing is longstanding. Moreover, for several decades, even the Court’s more liberal …

Liberal Constitutionalism And Economic Inequality, Rosalind Dixon, Julie Suk

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Economic inequality is rising in democracies across the world and poses a clear threat to both the stability and legitimacy of liberal constitutional models. Can liberal constitutionalism respond to this threat? Or are there inherent limits to the liberal model that prevent an effective response? This Essay explores these questions by surveying the range of possible structural and rights-based constitutional responses to economic inequality, as well as possible obstacles to these responsesincluding problems of definition, leveling up versus down, unintended or counterproductive consequences, and institutional path dependence.

Numerical Evaluation Of Microwave Thermal Ablation To Treat Small Adrenocortical Masses, G. Ruvio, J. Eaton-Evans, A. Shahzad, M. O’Halloran

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In this paper microwave thermal ablation is numerically evaluated in the context of a treatment for Conn’s Syndrome. This condition is caused by a benign shallow tumour in the cortex of adrenal gland. The modelling and design of microwave applicator to deliver thermal ablation to the adrenal gland requires accurate tissue characterisation. Measuring the dielectric properties of the constituent tissues in the adrenal gland, i.e. cortex and medulla, enables more accurate numerical modelling for electromagnetic and thermal simulations. This study presents an anatomically and dielectrically realistic numerical model of the adrenal gland, and investigates the feasibility of applying controlled heating …

Liminal Entrepreneuring: The Creative Practices Of Nascent Necessity Entrepreneurs, Lucia Garcia-Lorenzo, Paul Donnelly, Lucia Sell-Trujillo, J. Miguel Imas

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This paper contributes to creative entrepreneurship studies through exploring ‘liminal entrepreneuring’, i.e., the organization-creation entrepreneurial practices and narratives of individuals living in precarious conditions. Drawing on a processual approach to entrepreneurship and Turner’s liminality concept, we study the transition from un(der)employment to entrepreneurship of 50 nascent necessity entrepreneurs (NNEs) in Spain, the United Kingdom, and Ireland. The paper asks how these agents develop creative entrepreneuring practices in their efforts to overcome their condition of ‘necessity’. The analysis shows how, in their everyday liminal entrepreneuring, NNEs disassemble their identities and social positions, experiment with new relationships and alternative visions of themselves, …

Is Qualified Immunity Unlawful?, William Baude

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No abstract provided.

Cleaner Fuels For Ships Provide Public Health Benefits With Climate Tradeoffs, Mikhail Sofiev, James J. Winebrake, Lasse Johansson, Edward W. Carr, Marje Prank, Joana Soares, Julius Vira, Jukka-Pekka Jalkanen, James J. Corbett

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We evaluate public health and climate impacts of low-sulphur fuels in global shipping. Using high-resolution emissions inventories, integrated atmospheric models, and health risk functions, we assess ship-related PM 2.5 pollution impacts in 2020 with and without the use of low-sulphur fuels. Cleaner marine fuels will reduce ship-related premature mortality and morbidity by 34 and 54%, respectively, representing a ~ 2.6% global reduction in PM 2.5 cardiovascular and lung cancer deaths and a ~3.6% global reduction in childhood asthma. Despite these reductions, low-sulphur marine fuels will still account for ~250k deaths and ~6.4 M childhood asthma cases annually, and more stringent …

Partitioning Of Adipose Lipid Metabolism By Altered Expression And Function Of Ppar Isoforms After Bariatric Surgery, C Jahansouz, H Xu, A V. Hertzel, Kristin Ewing

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BACKGROUND:

Bariatric surgery remains the most effective treatment for reducing adiposity and eliminating type 2 diabetes; however, the mechanism(s) responsible have remained elusive. Peroxisome proliferator-activated receptors (PPAR) encompass a family of nuclear hormone receptors that upon activation exert control of lipid metabolism, glucose regulation and inflammation. Their role in adipose tissue following bariatric surgery remains undefined.

RESULTS:

Within 7 days, bariatric surgery acutely drives a change in the activity and expression of PPARγ and PPARδ in subcutaneous adipose tissue thereby attenuating lipid storage, increasing lipolysis and potentiating lipid oxidation. This unique metabolic alteration leads to changes in downstream PPARγ/δ targets …

How To Lose A Constitutional Democracy, Aziz Huq, Tom Ginsburg

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No abstract provided.

Innovative Contracting For Pharmaceuticals And Medicaid’S Best-Price Rule, Nicholas Bagley

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In recent years, drug manufacturers and private payers have expressed interest in novel pricing models that more closely link a drug’s price to its value. Indication-based pricing, outcome-based pricing, drug licenses, and drug mortgages have all been discussed as alternatives to paying strictly for volume. Manufacturers and payers have complained, however, that Medicaid’s “best-price rule” inhibits their ability to enter into these newpricing arrangements. This article examines the best-price rule and assesses to what extent, if any, it might frustrate the goal of paying for value. We conclude that the best-price rule is not as serious a problem as it …

Towards A Digital Earth: Using Archetypes To Enable Knowledge Interoperability Within Geo-Observational Sensor Systems Design, Paul Stacey, Damon Berry

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Earth System Science (ESS) observational data are often inadequately semantically enriched by geo-observational information systems in order to capture the true meaning of the associated data sets. Data models underpinning these information systems are often too rigid in their data representation to allow for the ever-changing and evolving nature of ESS domain concepts. This impoverished approach to observational data representation reduces the ability of multi-disciplinary practitioners to share information in a computable way.

Object oriented techniques typically employed to model data in a complex domain (with evolving domain concepts) can unnecessarily exclude domain specialists from the design process, invariably leading …

Economic Analysis In Labor Regulation, Hiba Hafiz

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No abstract provided.

Institutional Loyalties In Constitutional Law, Aziz Huq, David Fontana

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No abstract provided.

Investigation Of Temperature Response Of Photopolymer Material Used For Holographic Sensor, Muhammad Irfan Dr, Tatsiana Mikulchyk Dr, Suzanne Martin Dr, Izabela Naydenova Prof

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Recently, functionalised photopolymer has emerged as a versatile recording material in the field of optical holography due to its novel characteristics and potential use in the development of holographic based sensors, and optical elements. This work describes the temperature response of a newly developed photopolymer, containing of a monomer Nisopropylacrylamide (NIPA) which under photopolymerisation forms a temperature sensitive polymer - Poly(Nisopropylacrylamide) (PNIPA). The photonic sensor was developed by holographic recording of volume phase transmission gratings in a self-processing NIPA-based polymer with a 532 nm laser beam. A 633 nm probe beam was used to monitor real time diffraction efficiency (DE) …

''It’S A Win-Win Situation” – Intergenerational Learning In Preschool And Elder Care Settings: An Irish Perspective, Carmel Gallagher, Anne Fitzpatrick

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This paper explores the level and sustainability of intergenerational practice in early years and elder care settings in Ireland. The paper is based on a small-scale research study involving interviews with sta in ve organizations and builds on ndings from previous research conducted for the TOY project (http://www.toyproject.net). The paper examines the pedagogies involved as well as the community context of intergenerational practice in early years and elder care settings. The ndings highlight that sustainable intergenerational practice is facilitated by strong pedagogies that support active and relational learning across the life course and by being embedded in robust community networks.

Carefree Masculinities In Ireland: Gender Conservatism And Neo-Liberalism, Niall Hanlon

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No abstract provided.

Social Care Students’ Learning In The Practice Placement In Ireland, Fiona Mcsweeney, David Williams

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The practice placement is a central component of social care education, being seen as where students develop their practice skills, self-awareness and apply theoretical knowledge. This research reports on social care students’ experiences of their practice placements, in particular how learning was achieved and what helped learning. An interpretivist approach was used in line with the acceptance of the individuality of students’ experiences. A volunteer sample of seventeen students were interviewed individually at the end of their final year in college. The interview transcripts were thematically analysed. Four themes were identified: the need for a balance between autonomy and doing …

A High-Temperature Humidity Sensor Based On A Singlemode-Side Polished Multimode-Singlemode Fiber Structure, Xianfan Wang, Ke Tian, Libo Yuan, Elfed Lewis, Gerald Farrell, Pengfei Wang

Articles

A relative humidity (RH) sensor based on a simple singlemode-side polished multimode-singlemode (SSPMS) fiber hybrid structure is investigated, which is capable of working over a relatively high-temperature range, at which many RH sensors based on moisture sensitive material coatings cannot operate. The beam propagation method is used to analyze the light transmission characteristics within the side polished multimode fiber (SPMMF) structure. Experimental results show that the SPMMF surface roughness has a significant influence on the sensor's humidity sensing performance, as a result of the adsorption and desorption of water molecules along the side polished surface. A higher surface roughness results …

The Run Of Ourselves: Shame, Guilt And Confession In Post-Celtic Tiger Irish Media, Marcus Free, Clare Scully

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This article examines the emergence of the themes of shame and guilt in Irish print and broadcast media in the wake of Ireland’s 2008 economic collapse. It considers how the potential search for explanation of the crisis as a manifestation of unregulated banking and development sectors was displaced onto a confessional discursive pattern in which emphasis was placed on rampant borrowing and consumption as reflective of collective narcissism and acquisitive greed. Hence the logic that ‘hubris’ led inevitably to a national fall from grace and the corresponding resurgence of postcolonial shame; and the interplay between cultural nationalist and neoliberal discourses …

Developing Meaningful Higher Education Evaluation Systems: Putting China In Context, Ellen Hazelkorn, Lu Liu

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This paper firstly reviews how issues of accountability and transparency have become some of the key drivers of government policy over recent years. It finds that the drive for greater higher education accountability and transparency has encouraged the growth of an international evaluation industry. It secondly discusses issues related to different types of policy and evaluation instruments across Europe, as well as the importance of rankings. It finds that traditional approaches have relied on collegiality, expert judgment, and peer review, and there is a growing focus on indicator-led systems in the belief that indicators are value-free and statistically robust so …

The Roles Of Social Entrepreneurs In Rural Destination Development, Ziene Mottiar, Karla Boluk, Carol Kline

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This paper examines the relevance of social entrepreneurs in our consideration of rural destination development, which represents an important tool for rural revitalization. While many peripheral rural areas face significant challenges in terms of sustaining communities and attracting tourists, it is often social entrepreneurs, as much as traditional entrepreneurs, who are involved in developing new ideas, products and activities, as well as envisioning a future for the area. This study, which is based on cross-case analysis resulting from nine semi-structured interviews carried out in rural areas in Ireland, South Africa and USA, identifies key roles that social entrepreneurs play in …

Interculturalism In Higher Education In Ireland: An Analysis From A Strategy, Policy And Practice Perspective, Brid Ni Chonaill

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Education is instrumental in preparing students to participate in increasingly diverse Irish, European and global societies, with higher education having a part to play in the process. Issues around migration and cultural diversity have gained less attention in the higher education sector in Ireland than at primary and post primary level with a few notable exceptions. Higher education is regarded as having a “critical role” to play in terms of “enriching Ireland’s cultural life, nurturing our understanding of our own national identity and that of other cultures and belief systems” [1]. Influenced by developments at European Union level, the approach …