Digital Commons Network^™

“The Very Essence Of French Cinema”(?): Jacques Feyder’S Return To France, 1944–1948, Barry Nevin

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No abstract provided.

Reflections On Post-Bailout Policy Analysis In Ireland, Mary Murphy, John Hogan

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This short article reflects on observations from the forthcoming volume Policy Analysis in Ireland, edited by Hogan & Murphy. The volume forms part of the International Library of Policy Analysis series, which covers more than twenty countries, published by Policy Press and edited by Michael Howlett and Iris Geva-May. While various themes emerge from the Irish volume, this article focuses on only one core question: whether and how the 2008 economic crisis contracted and expanded the capacity for policy analysis in Ireland. The troika of the International Monetary Fund, European Central Bank and the European Commission are associated with policy …

Entrepreneuring After 50: The Liminal Identity Transitions Of Older Emergent Entrepreneurs, Lucia Garcia-Lorenzo, Lucia Sell-Trujillo, Paul Donnelly

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Entrepreneurship has been proposed as a solution to extending working lives. However, little is known about how older (50+) entrepreneurs manage their personal transitions into entrepreneurship. In this paper, we propose to use a liminal identity work perspective to explore the identity paradoxes that older entrepreneurs experience during their transition into entrepreneurship and how they manage it. We use a qualitative study conducted over 14 months in the United Kingdom. Our analysis shows how older entrepreneurs confront identity paradoxes, interruptions and identity polarization in their attempts to shift from older identities and activity patterns into new ones. The entrepreneurs who …

Gender-Related Differences In Flood Risk Perception And Behaviours Among Private Groundwater Users In The Republic Of Ireland, Cillian P. Mcdowell, Luisa Andrade, Eoin O'Neill, Kevin O'Malley, Jean O'Dwyer, Paul Hynds

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Extreme weather events including flooding can have severe personal, infrastructural, and economic consequences, with recent evidence pointing to surface flooding as a pathway for the microbial contamination of private groundwater supplies. There is a pressing need for increasingly focused information and awareness campaigns to highlight the risks posed by extreme weather events and appropriate subsequent post-event actions. To date, little is known about the presence, directionality or magnitude of gender-related differences regarding flood risk awareness and behaviour among private groundwater users, a particularly susceptible sub-population due to an overarching paucity of infrastructural regulation across many regions. The current study investigated …

The Viability Of Organic Dyes In Luminescent Down-Shifting Layers For The Enhancement Of Si Solar Cell Efficiency, Aaron Glenn, Conor Mcloughlin, Hind Ahmed, Hoda Akbari, Subhash Chandra, Sarah Mccormack

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The main energy losses in solar cells are related to spectral losses where high energy photons are not used efficiently, and energy is lost via thermalization which reduces the solar cell’s overall efficiency. A way to tackle this is to introduce a luminescent down-shifting layer (LDS) to convert these high energy photons into a lower energy bracket helping the solar cell to absorb them and thus generating a greater power output. In this paper, lumogen dye Violet 570 has been used as LDS coated films of 10μm and 60μm placed on top of Si solar cells. The dye was incorporated …

Contamination Of Domestic Groundwater Systems By Verotoxigenic Escherichia Coli (Vtec), 2003–2019: A Global Scoping Review, C. Chique, Paul Hynds, L.P. Burke, D. Morris, M.P. Ryan, J. O'Dwyer

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Verocytotoxin-producing E. coli (VTEC) are important agents of diarrhoeal disease in humans globally. As a noted waterborne disease, emphasis has been given to the study VTEC in surface waters, readily susceptible to microbial contamination. Conversely, the status of VTEC in potable groundwater sources, generally regarded as a “safe” drinking-water supply remains largely understudied. As such, this investigation presents the first scoping review seeking to determine the global prevalence of VTEC in groundwater supply sources intended for human consumption. Twenty-three peer-reviewed studies were identified and included for data extraction. Groundwater sample and supply detection rates (estimated 0.6 and 1.3%, respectively) indicate …

Investigation Of The Chemical Composition Of Plasma-Treated Water By Midiplexc And Its Antimicrobial Effect On L. Monocytogenes And Pseudomonas Fluorescens Monospecies Suspension Cultures, Oliver Handorf, Harald Below, Uta Schnabel, Katharina Riedel

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Plasma -generated compounds conceived by microwave -induced plasma (MidiPLexc) were physicochemically investigated in their molecular compositions. Therefore, plasma -treated water (PTW) was generated by treatment with the MidiPLexc within a 1 l glass bottle for a pre -treatment time of 100 s, 300 s and 900 s. The PTW was further investigated in its composition of reactive oxygen/nitrogen species. For this purpose, the hydrogen peroxide (H2O2) concentration of the PTW was determined electrochemically using chronoamperometry, and the anionic components were determined using ion chromatography. As a result, H2O2 concentrations of up to 720 mg l−1 , nitrite concentrations of 1600 …

Analysis Of A Large Spatiotemporal Groundwater Quality Dataset, Ontario 2010–2017: Informing Human Health Risk Assessment And Testing Guidance For Private Drinking Water Wells, Tessa Latchmore, Paul Hynds, R. Stephen Brown, Corinne Schuster-Wallace, Sarah Dickson-Anderson, Kevin Mcdermott, Anna Majury

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Approximately 1.5 million individuals in Ontario are supplied by private water wells (private groundwater supplies). Unlike municipal supplies, private well water quality remains unregulated, with owners responsible for testing, treating, and maintaining their own water supplies. The primary goal of this study was to assess the effect of repeat sampling of private well water in Ontario and investigate the efficacy of geographically- and/or temporally specific testing recommendations and health risk assessments. The current study combines the Well Water Information System Dataset and the Well Water Testing Dataset from 2010 to 2017, inclusive. These two large existing province-wide datasets collated over …

Knowledge And Behavioural Interventions To Reduce Human Health Risk From Private Groundwater Systems: A Global Review And Pooled Analysis Based On Development Status, S. Mooney, C. P. Mcdowell, J. O'Dwyer, P. D. Hynds

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Groundwater contamination constitutes a significant health risk for private well users residing in rural areas. As the responsibility to safeguard rural private domestic groundwater typically rests with non-expert homeowners, interventions promoting risk mitigation and awareness represent the most viable means of preventing supply contamination. However, no global review or pooled analyses of these interventions has been undertaken to date. The current study sought to identify and quantify the performance of private well interventions from 1990 to 2018 via a global systematised review and pooled analysis. The PICO (Population-Intervention-Comparison-Outcome) approach was employed for literature identification. Relevant studies were statistically analysed across …

Risk Communication Approaches For Preventing Private Groundwater Contamination In The Republic Of Ireland: A Mixed-Methods Study Of Multidisciplinary Expert Opinion, S. Mooney, J. O'Dwyer, Paul Hynds

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The mechanisms of private-well groundwater contamination are uniquely complex, necessitating a multisector communicative approach to risk management, premised on behaviour promotion. In countries such as the Republic of Ireland (ROI), characterised by oftentimes high groundwater contamination risk and concurrently limited user awareness, incorporation of multidisciplinary, ‘expert-based’ knowledge may facilitate design of evidence-based, practical interventions. Expert interviews represent an efficient form of expert consultation, enabling ease of access to niche information and comparison of procedure, but remain under-utilised within the groundwater management literature. In response, the current study elicited opinion from 50 experts across four broad categories (communications, engineering/science, policy, and …

Covid-19: A Simple Curve Approximation Tool, Jane Courtney

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In the current COVID-19 pandemic, much focus is put on ‘flattening the curve’. This ‘curve’ refers to the cases versus time graph, which shows the rise of a disease to its peak before descending. The aim in a pandemic is to flatten this curve by reducing the peak and spreading out the timeline. However, the models used to predict this curve are often not clearly outlined, no model parameters are given, and models are not tested against real data. This lack of detail makes it difficult to recreate the curve from these models. What is much needed is a simple …

Cognitive Performance In Midlife Type 2 Diabetes: Results Form The Enbind Study, A. H. Dyer, L. Mckenna, G. Gamage, N. M. Bourke, Isabelle Killane, M. Widdowson, C. P. Woods, J. Gibney, R. Reilly, D. O'Neill, S. P. Kennelly

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Aims: To establish the impact of uncomplicated type 2 diabetes on cognitive and neuropsychological performance in midlife. Methods: We performed a cross-sectional study of middle-aged adults with uncomplicated type 2 diabetes and a cohort of healthy control participants. General cognition was assessed using the Montreal Cognitive Assessment test and neuropsychological assessment was undertaken using a detailed neuropsychological assessment battery. Results: A total of 152 participants (102 with type 2 diabetes and 50 controls) were recruited (mean age 52 ± 8 years, 51% women). Participants with midlife type 2 diabetes were more than twice as likely to make an error on …

Entrepreneurial Process Studies Using Insider Action Research: Opportunities & Challenges For Entrepreneurship Scholarship, Kisito Futonge Nzembayie, Anthony Paul Buckley

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This paper examines the opportunities and challenges of adopting Insider Action Research (IAR) in entrepreneurial process studies. It employs a critical reflexive and narrative approach in examining our own lived experience in a real-time digital entrepreneurial journey spanning three years while triangulating it with experiential knowledge in another role as dissertation supervisors. Our live case illustrates that IAR, when it combines reflective practice, cooperative inquiry and design science, represents a suitable but under-exploited methodology for entrepreneurship scholarship. We build on this knowledge to offer a model for incorporating this methodology in entrepreneurship research and education. Consequently, we contribute towards responding …

What Do Professional Drivers Think About Their Profession? An Examination Of Factors Contributing To The Driver Shortage, Chao Ji Hyland, Declan Allen

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A shortage of qualified and available professional drivers in the Freight, Transport, Distribution and Logistics (FTDL) sector is becoming an area of increasing concern in Ireland, and across the European mainland. This paper applies a two-stage research approach to address the issues causing the driver shortage and to analyse contributing factors. The findings reveal that remuneration and salaries are detrimental to recruitment and retention. While driver wellbeing in terms of physical and mental health is a major issue, little support is provided for training and education. There is a relationship between a driver’s age group and job satisfaction, and between …

Incentivizing And Re-Engaging Lapsed Health Club Members, Teresa Hurley, Corinne Faure, Seamus Kelly

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Purpose – This quantitative research paper examined factors influencing re-engagement intentions and re-engagement behavior of lapsed health club members and identified which sales promotion incentives are most effective in re-engaging this lapsed member market. While previous studies examined reengagement intentions and re-engagement behavior in isolation, no research could be located which examined both simultaneously and the impact of promotion incentives in the health and fitness industry.

Design/methodology/approach – Study A (mail survey) examined re-engagement intentions of one hundred lapsed members of a medium size suburban health club. Study B (an experimental field study) measured actual true re-engagement behavior using price …

Stakeholder Engagement And The Future Of Irish Public–Private Partnerships, Gail Sheppard, Matthias Beck

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Building on recent works that stress the importance of stakeholder engagement in partnerships, we propose a novel benchmarking framework for the evaluation of public–private partnerships. This framework describes mutuality and the preservation of organisational identity as the ideal characteristics of partnerships because they, in turn, encourage stakeholder support for public–private partnerships. Applying this framework to infrastructure public–private partnerships in Ireland, we note that mutual accountability has been weakened following the financial crisis. Meanwhile, con-sultation with clients such as key public–private partnership stakeholders, which would help articulate organisational identities, remains patchy across the education, justice
and health public–private partnership that we …

The Relationship Between Financial Distress And Well-Being: Exploring The Role Of Self-Employment, Jenny Berrill, Damien Cassells, Martha O’Hagan-Luff, André Van Stel

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No abstract provided.

Optimising Subjective Anterior Eye Grading Precision, Marta Vianya-Estopa, Manbir Nagra, Arnold Cochrane Arnold Cochrane, Neil Retallic Neil Retallic, Dean Dunning, Louise Terry Louise Terry, Aoife Lloyd, James Wolffsohn

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To establish the optimum grading increment which ensured parity between practitioners while maximising clinical precision.

Data Mining Raman Microspectroscopic Responses Of Cells To Drugs In Vitro Using Multivariate Curve Resolution-Alternating Least Squares, David Perezguaita, Guillermo Quintas, Zeineb Farhane, Roma Tauler, Hugh Byrne

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Raman microspectroscopy is gaining popularity for the analysis of time-dependent biological processes such as drug uptake and cellular response. It is a label-free technique which acquires signals from a large variety of components, including cell biomolecules and exogenous compounds such as drugs and nanoparticles, and is commonly employed for in vitro analysis of cells and cell populations with no labelling or staining required. By monitoring the changes to the Raman spectra of the cell as a result of a perturbing agent (e.g. exposure to a drug or toxic agent), one can study the associated changes in cell biochemistry involved in …

Potential Of Raman Spectroscopy For The Analysis Of Plasma/Serum In The Liquid State: Recent Advances, Drishya Rajan Parachalil, Jennifer Mcintyre, Hugh Byrne

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There is compelling evidence in the literature to support the application of Raman spectroscopy for analysis of bodily fluids in their native liquid state. Naturally, the strategies described in the literature for Raman spectroscopic analysis of liquid samples have advantages and disadvantages. Herein, recent advances in the analysis of plasma/serum in the liquid state are reviewed. The potential advantages of Raman analysis in the liquid form over the commonly employed infrared absorption analysis in the dried droplet form are initially highlighted. Improvements in measurement protocols based on inverted microscopic geometries, clinically adaptable substrates, data preprocessing and analysis, and applications for …

Atr-Ir Spectroscopy For Rapid Quantification Of Water Content In Deep Eutectic Solvents, Suha Elderderi, Charlotte Leman-Loubiére, Laura Wills, Sandra Henry, Dominique Bertrand, Hugh Byrne, Igor Chourpa, Cécile Enguehard-Gueiffier, Emilie Munnier, Abdalla A. Elbashir, Leslie Boudesocque-Delaye, Franck Bonnier

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Natural Deep Eutectic solvents (NADES) are green, ionic solutions prepared by mixing vegetal cellular constituents. They are renewable and biodegradable solvents composed of hydrogen bonded donor and acceptor compounds. NADES have a wide range of applications, mainly as solvents for extraction of plants, biocatalysis, and nanoparticle synthesis. Water content is very critical, impacting significantly on NADES properties. Therefore, controlling H2O concentration appears essential for optimal use of NADES. In the present study, Attenuated Total Reflectance – infrared spectroscopy (ATR-IR) coupled to multivariate analysis, namely Partial Least Square s regression (PLSR), was investigated as a rapid, label free and cost-effective tool …

Exploiting Fourier Transform Infrared And Raman Microspectroscopies On Cancer Stem Cells From Oral Squamous Cells Carcinoma: New Evidence Of Acquired Csplatin Chemoresistance, Valentina Notarstefano, Simona Sabbatini, Chiaro Pro, Alessia Belloni, Giulia Orilisi, Corrado Rubini, Hugh Byrne, Lisa Vaccari, Elisabetta Giorgini

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Oral Squamous Cells Carcinoma (OSCC) is characterised by the risk of recurrence and the onset of a refractoriness response to chemotherapy drugs. These phenomena have been recently related to a subpopulation of Cancer Stem Cells (CSCs), which have either an innate or acquired drug resistance, triggered by chemotherapy treatments. In this light, to precisely target chemotherapy regimens, it is essential to improve knowledge on CSCs, with a particular focus on their molecular features. In this work, a subpopulation of CSCs, isolated by tumour sphere formation from primary OSCC cells, were treated with cisplatin for 16, 24 and 48 hours and …

Ireland, Broadcasting And The Spectrum Wars, Kenneth W Murphy

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This paper offers an overview and evaluation of Ireland’s changing media landscape through the prism of the recent policy contestation surrounding the future use of the UHF spectrum and it’s implications for the medium of television broadcasting. The article brings into focus current policy and governance developments and their interplay with market and technological change and how they are shaping a small open European state’s adaptation to the increasingly complex national/global hybrid media ecosystem. It examines the contexts surrounding the competition for spectrum resources and its implications for the role of free to air broadcasting and mobile broadband technologies in …

Creating Bespoke Note By Note Dishes And Drinks Inspired By Traditional Foods, Roisin Burke, Pauline Danaher, David Hurley

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No abstract provided.

Bioactive Indanes: Development And Validation Of An Lc-Ms/Ms Bioanalytical Method For The Determination Of Ph46a, A New Potential Anti-Inflammatory Agent, In Dog And Rat Plasma And Its Application To A Pharmacokinetic Study In Dog, Gaia Scalabrino, Tao Zhang, Neil Frankish, Helen Sheridan

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A new chemical entity, which is a chiral indane dimer, PH46A, has been developed by our research group. As a clinical candidate. PH46A has recently completed Phase I clinical studies in man. Previously, during its pre-clinical development, in in vivo pre-clinical studies PH46A showed potent anti-inflammatory properties, which can be targeted at a range of diseases, including inflammatory bowel disease (IBD). To support the pre-clinical development of this drug candidate, we developed a LC MS/MS method for determining PH46 (the acid form of PH46A salt) in both dog and rat plasma using Compound 1 as internal standard (IS). Those species …

Bioactive Indanes: Insight Into The Bioactivity Of Iindane Dimers Related To The Lead Anti‐Inflammatory Molecule Ph46a, Kit Chan, Neil Frankish, Tao Zhang, Abdulilah Ece, Aoife Cannon, Jacintha O’Sullivan, Helen Sheridan

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Objectives PH46A (1) demonstrates significant anti-inflammatory activity in phenotypic models but its mechanism and site of action have been elusive. Current study focused on the bioactivity of PH46 (2) and related novel indane dimers (6-10) to investigate the impact of changes in substitution and stereochemistry at the C-1 and C-2 positions of the PH46 (2) scaffold.

Methods Cytotoxicity profiles of compounds were established using THP-1 macrophages and SW480 cells. Effects of the compounds were then evaluated at 10 μM using 5-lipoxygenase (LOX) and 15-LOX enzymes, and 5-LOX binding was evaluated in silico against NDGA, nitric oxide (NO) released from LPS-induced …

From Nature To Medicinal Chemistry: Anti-Cancer Activity Of Novel Indane Scaffolds, Tao Zhang, Vilmar Bandero-Filho, Kit Chan, Lorraine O’Driscoll, Neil Frankish, Helen Sheridan

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No abstract provided.

Drug Discovery: Novel Indane Scaffolds With Anticancer Activity, Vilmar Bandero, Tao Zhang, Kit Chan, Lorraine O’Driscoll, Claire Corcoran, Neil Frankish, Helen Sheridan

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No abstract provided.

Novel Mast Cell-Stabilising Amine Derivatives Of 3,4 Dihydronaphthalen-1(2h)-One And 6,7,8,9-Tetrahydro-5h-Benzo[7]Annulen-5-One, James W. Barlow, Tao Zhang, Orla Woods, Adam J. Byrne, John J. Walsh

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In an investigation of 4-amino-3,4-dihydronaphthalen-1(2H)-ones as novel modulators of allergic and inflammatory phenomena, we have investigated a series of cyclic analogues. Tertiary amines of structural types 9, 10, 20 and 21 were synthesised and evaluated for mast cell stabilising activity. In vitro and in vivo studies showed that of these compounds, the cyclohexenylamino derivatives of tetralone and benzosuberone of series 20 and 21 exhibited interesting activity both in vitro and in vivo.

Mast Cell Stabilisers, Tao Zhang, Deirdre Frances Finn, James William Barlow, John Jarlath Walsh

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Mast cells play a critical role in type 1 hypersensitivity reactions. Indeed, mast cell mediators are implicated in many different conditions including allergic rhinitis, conjunctivitis, asthma, psoriasis, mastocytosis and the progression of many different cancers. Thus, there is intense interest in the development of agents which prevent mast cell mediator release or which inhibit the actions of such mediators once released into the environment of the cell. Much progress into the design of new agents has been made since the initial discovery of the mast cell stabilising properties of khellin from Ammi visnaga and the clinical approval of cromolyn sodium. …