Digital Commons Network^™

Cutinase From Amycolatopsis Mediterannei: Marked Activation And Stabilisation In Deep Eutectic Solvents, Yeqi Tan, Gemma K. Kinsella, Gary T. Henehan, Barry J. Ryan

Articles

Amycolatopsis mediterranei cutinase (AmCut) has potential biocatalytic applications in plastics degradation and ester synthesis. Deep Eutectic Solvents (DES) are next generation biodegradable solvents for biocatalysis. However, the behaviour of cutinase enzymes in DES is little studied. Herein, we examine the effect of selected DES, and their components, on AmCut activity and stability. Low amounts (10% v/v) of DES (choline chloride:glycerol; 1:1 mole ratio) caused striking activation of AmCut (over 2-fold). Further examination showed that the choline chloride component of DES caused the observed activation. This is the first report of activation of a cutinase by a small molecule. At higher …

Profiling Food Festivals By Type, Name And Descriptive Content: A Population Level Study, Muhammet Kesgin, Rajendran S. Murthy, Rick Lagiewski

Articles

Purpose: This research aims to classify and describe food festivals and examine the patterns in food festival naming and festival descriptions in online media. Design: This research represents the first population-level empirical examination of food festivals in the United States using a purpose-built dataset (N=2626). Methodology includes text mining to examine food festival communications. Findings: Food festival size varies across local and regional spheres within the country. Food festivals employ geographical (place-, destination-based) associations in their names. Food festivals’ descriptions and online communications showcase a welcoming environment predominantly emphasizing family-oriented and live entertainment experiences. Food festivals across the country show …

Realising Compact Growth In Dublin; Reviewing Measures Adopted By Local Authorities To Concentrate Development Along The Proposed Metrolink Luas Greenline Transport Corridor, Paul J. Lawlor Mr

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Since 1999, there have been a noticeable evolution in the Irish national and regional planning policy towards concentrating new development within the footprint of existing towns and cities. The approach of ‘realising compact growth’ has numerous benefits including reducing carbon emissions, making more effective and economic use of existing infrastructure, avoiding urban sprawl and helping to achieve more balanced regional development. To enable its achievement, the National Planning Framework (NPF) and the Regional Spatial and Economic Strategies (RSESs) have set ambitious targets for compact urban growth and they include measures that are designed to promote the development of vacant and …

Medicare Coverage Of Aducanumab - Implications For State Budgets, Rachel E. Sachs, Nicholas Bagley

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Aducanumab (Aduhelm), the controversial $56,000-per-year Alzheimer’s disease drug approved by the Food and Drug Administration (FDA) in June 2021, has the potential to cost the federal government many billions of dollars — more, by one estimate, than it spends on agencies such as the Environmental Protection Agency or the National Aeronautics and Space Administration. The drug’s extraordinary price tag helps explain why, soon after its approval, the Centers for Medicare and Medicaid Services (CMS) opened a national coverage determination to decide whether and under what circumstances Medicare would pay for it.1

A Survey Of Machine Learning Techniques For Video Quality Prediction From Quality Of Delivery Metrics, Obinna Izima, Ruairí De Fréin, Ali Malik

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A growing number of video streaming networks are incorporating machine learning (ML) applications. The growth of video streaming services places enormous pressure on network and video content providers who need to proactively maintain high levels of video quality. ML has been applied to predict the quality of video streams. Quality of delivery (QoD) measurements, which capture the end-to-end performances of network services, have been leveraged in video quality prediction. The drive for end-to-end encryption, for privacy and digital rights management, has brought about a lack of visibility for operators who desire insights from video quality metrics. In response, numerous solutions …

A Strategy Model For Workplace Mediation Success, Brian M. Barry Dr

Articles

The article proposes a three-step model to help workplace mediators decide on the optimum strategy for mediating workplace disputes. The model uses a grid – the Workplace Mediation Strategy Grid – which is based on a modified version of a grid Professor Leonard Riskin developed for categorising mediation orientations (Riskin 1994; Riskin 1996). The model asks the mediator to first consider the nature of the workplace dispute based on three facets of the dispute. This guides the mediator to plot a position on the Grid which represents two fundamental aspects of strategy for mediating that dispute: (1) how broadly the …

Beyond The Public Square: Imagining Digital Democracy, Mary Anne Franks

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To create online spaces that do not merely replicate existing hierarchies and reinforce unequal distributions of social, economic, cultural, and political power, we must move beyond the simplistic clich6 of the unregulated public square and commit to the hard work of designing for democracy.

When we say 'public square,' ... we need to ask- who or what is this public? Who owns this space, what makes it public? . . . This is the essence of democracy: the ability to question power, and the power to do so. - Tom Wilkinson

Provenance: An Intermediary-Free Solution For Digital Content Verification, Bilal Yousuf, M. Atif Qureshi, Brendan Spillane, Gary Munnelly, Oisin Carroll, Matthew Runswick, Kirsty Park, Eileen Culloty, Owen Conlan, Jane Suiter

Articles

The threat posed by misinformation and disinformation is one of the defining challenges of the 21st century. Provenance is designed to help combat this threat by warning users when the content they are looking at may be misinformation or disinformation. It is also designed to improve media literacy among its users and ultimately reduce susceptibility to the threat among vulnerable groups within society. The Provenance browser plugin checks the content that users see on the Internet and social media and provides warnings in their browser or social media feed. Unlike similar plugins, which require human experts to provide evaluations and …

Optimization Of Unit Operations For Microencapsulating Ferrous Fumarate During Scale-Up Of Double Fortification Of Salt With Iron And Iodine, Oluwasegun Modupe, Kiruba Krishnaswamy, Yao Olive Li, Levente L. Diosady

Articles

Objectives: This study evaluates factors responsible for the floating of iron premix in double fortified salt (DFS), which initially affected the large-scale implementation of the salt fortification program in India, and provides solutions to the scale-up of the technology.

Materials and Methods: To mitigate this time-sensitive scale-up challenge. First, the iron premix samples were obtained from the industrial scale-up pilot studies in India, evaluated for the impact of the amount of coating material (5 per cent, 7.5 per cent, and 10 per cent (in weight)), type of formulation (soy stearin, SEPIFILM and hydroxypropyl methylcellulose), amount of titanium dioxide (25-35 per …

Problematic Interactions Between Ai And Health Privacy, W. Nicholson Price Ii

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Problematic Interactions Between AI and Health Privacy Nicholson Price, University of Michigan Law SchoolFollow Abstract The interaction of artificial intelligence (AI) and health privacy is a two-way street. Both directions are problematic. This Essay makes two main points. First, the advent of artificial intelligence weakens the legal protections for health privacy by rendering deidentification less reliable and by inferring health information from unprotected data sources. Second, the legal rules that protect health privacy nonetheless detrimentally impact the development of AI used in the health system by introducing multiple sources of bias: collection and sharing of data by a small set …

Towards A Framework For Comparing Functionalities Of Multimorbidity Clinical Decision Support: A Literature-Based Feature Set And Benchmark Cases., Dympna O'Sullivan, William Van Woensel, Szymon Wilk, Samson Tu, Wojtek Michalowski, Samina Abidi, Marc Carrier, Ruth Edry, Irit Hochberg, Stephen Kingwell, Alexandra Kogan, Martin Michalowski, Hugh O'Sullivan, Mor Peleg

Articles

Multimorbidity, the coexistence of two or more health conditions, has become more prevalent as mortality rates in many countries have declined and their populations have aged. Multimorbidity presents significant difficulties for Clinical Decision Support Systems (CDSS), particularly in cases where recommendations from relevant clinical guidelines offer conflicting advice. A number of research groups are developing computer-interpretable guideline (CIG) modeling formalisms that integrate recommendations from multiple Clinical Practice Guidelines (CPGs) for knowledge-based multimorbidity decision support. In this paper we describe work towards the development of a framework for comparing the different approaches to multimorbidity CIG-based clinical decision support (MGCDS). We present …

Professional Caring In Affective Services; The Ambivalence Of Emotional Nurture In Practice, Niall Hanlon

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Emotional nurturance is a fundamental feature of all forms of professional caring. As well as delivering expert social, health, education, practical or personal services, good caregivers possess an other-centred disposition, are emotionally intelligent and relationally skilled, and morally caring. Despite this, the value, role, and status of emotional nurturance in professional care is ambivalent. Drawing on feminist care theory, Hochchild’s emotional labour theory, and Bourdieusian social reproduction theory, as well as diverse empirical studies, this paper identifies how emotion is marginalised and misrecognised and calls for the reappraisal of emotion in professional care work in ways that appreciate tensions, contradictions, …

A Quantitative Evaluation Of Global, Rule-Based Explanations Of Post-Hoc, Model Agnostic Methods, Giulia Vilone, Luca Longo

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Understanding the inferences of data-driven, machine-learned models can be seen as a process that discloses the relationships between their input and output. These relationships consist and can be represented as a set of inference rules. However, the models usually do not explicit these rules to their end-users who, subsequently, perceive them as black-boxes and might not trust their predictions. Therefore, scholars have proposed several methods for extracting rules from data-driven machine-learned models to explain their logic. However, limited work exists on the evaluation and comparison of these methods. This study proposes a novel comparative approach to evaluate and compare the …

Rces: Rapid Cues Exploratory Search Using Taxonomies For Covid-19, Wei Li, Rishi Choudhary, Arjumand Younus, Bruno Ohana, Nicole Baker, Brendan Leen, Muhammad Atif Qureshi

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To assist the COVID-19 focused researchers in life science and healthcare in understanding the pandemic, we present an exploratory information retrieval system called RCES. The system employs a previously developed EVE (Explainable Vector-based Embedding) model using DBpedia and an adopted model using MeSH taxonomies to exploit concept relations related to COVID-19. Various expansion methods are also developed, along with explanations and facets that collectively form rapid cues for a valuable navigational and informed user experience.

Shifting The Eu Taxonomy From Theory To Practice: A Review Of The Literature Highlighting Potential Academic Contributions To Its Adoption, Implementation, And Impact, Dylan Kirby, Sandra Thompson, Cormac H. Macmahon

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The EU Taxonomy seeks to identify those sustainable economic activities, thereby supporting climate change mitigation and adaptation. Recent legislation underpinning the EU Taxonomy, such as the Non-Financial Reporting Directive (NFRD) and the Sustainable Finance Disclosure Regulation (SFDR), highlight the urgency for academic contributions that might shed light on its operationalisation. At this embryonic stage in the Taxonomy’s lifecycle, there is potential for the academic community to contribute to understanding its implications. Hence, we undertake a thematic analysis of predominantly, but not exclusively, professional literature to prioritise potential empirical research or conceptualisations that might offer insights for finance and accounting professionals, …

Property Law For The Ages, Michael C. Pollack, Lior Jacob Strahilevitz

Articles

Within the next forty years, the number of Americans over age sixty-five is projected to nearly double. This seismic demographic shift will necessitate a reckoning in several areas of law and policy, but property law is especially unprepared. Built primarily for young and middle-aged white men, the common law of property has been critiqued for decades for the ways in which it oppresses or simply leaves behind people based on their race, sex, Native heritage, and more. This Article contributes a new focus on property law’s treatment of people based on their advanced age. Burdened by higher relocation costs, more …

Direct Oral Anticoagulants For Stroke Prevention In Patients With Atrial Fibrillation And Bioprosthetic Heart Valves, Vardhmaan Jain, Kirtipa Bhatia, Devika Aggarwal, Agam Bansal, Bharat Narasimhan, Michael J. Hendrickson, Sameer Arora, Michael J. Ricciardi, Arman Qamar

Articles

No abstract provided.

Synergistic Anticancer Response Of Curcumin And Piperine Loaded Lignin-G-P (Nipam-Co-Dmaema) Gold Nanogels Against Glioblastoma Multiforme, Xinyi Zhao, Bilal Javad, Daxing Cui, James Curtin, Furong Tian

Articles

Glioblastoma multiforme (GBM) is the most aggressive and commonly diag- 11 nosed brain cancer and presents a strong resistance to routine chemotherapeutic drugs. 12 The present study involves the synthesis of Lignin-g- p (NIPAM-co-DMAEMA) gold 13 nanogel, loaded with curcumin and piperine to treat GBM. The application has three 14 functions: (1) overcome the limitations of biodistribution, (2) enhance the toxicity of an- 15 ticancer drugs against GBM, (3) identify the uptake pathway. Atom transfer radical 16 polymerization was used to synthesize the Lignin-g-PNIPAM network, crosslinked with 17 the gold nanoparticles (GNPs) to self-assemble into nanogels. The size distribution and …

Enhanced Anticancer Response Of Curcumin- And Piperine-Loaded Lignin-G-P (Nipam-Co-Dmaema) Gold Nanogels Against U-251 Mg Glioblastoma Multiforme, Bilal Javed, Xinyi Zhao, Daxiang Cui, James Curtin, Furong Tian

Articles

Glioblastoma multiforme (GBM) is the most aggressive and commonly diagnosed brain cancer and is highly resistant to routine chemotherapeutic drugs. The present study involves the synthesis of Lignin-g-p (NIPAM-co-DMAEMA) gold nanogel, loaded with curcumin and piperine, to treat GBM. The ongoing study has the application potential to (1) overcome the limitations of drugs biodistribution, (2) enhance the toxicity of anticancer drugs against GBM, and (3) identify the drugs uptake pathway. Atom transfer radical polymerization was used to synthesize the Lignin-g-PNIPAM network, crosslinked with the gold nanoparticles (GNPs) to self-assemble into nanogels. The size distribution and morphological analysis confirmed that the …

Caring For The Souls Of Our Students: The Evolution Of A Community Economic Development Clinic During Turbulent Times, Gowri J. Krishna, Kelly Pfeifer, Dana Thompson

Articles

Community Economic Development (CED) clinicians regularly address issues surrounding economic, racial, and social justice, as those are the core principles motivating their work to promote vibrant, diverse, and sustainable communities. When COVID-19 arrived, and heightened attention to police brutality and racial injustice ensued, CED clinicians focused not only on how to begin to address these issues in their clinics, but on how to discuss these issues more deeply and effectively with their students. This essay highlights the ways in which the pandemic school year influenced significant rethinking of one CED clinic’s operations: first, the pandemic sharpened the clinic’s mission to …

Quantifying Parent Engagement In The Randomized Fuel For Fun Impact Study Identified Design Considerations And Bmi Relationships, Barbara A. Lohse, Leslie Cunningham-Sabo

Articles

Background: Parent participation in children’s health interventions is insufciently defned and measured. This project quantifed parent participation to enable future examination with outcomes in an intervention focused on 4th graders, aged 9–11 years, and their families living in northern Colorado.

Methods: Indices were developed to measure type (Parent Participation Profle; PPP) and intensity (Parent Engage‑ ment Intensity; PEI) of engagement in Fuel for Fun (FFF), an asymmetric school-and family-based intervention for 4th graders. Study arm-specifc participation opportunities were catalogued and summed to calculate the PPP. An algo‑ rithm considered frequency, efort, convenience, and invasiveness of each activity to calculate PEI. …

Teaching Meiosis With The Dna Triangle Framework: A Classroom Activity That Changes How Students Think About Chromosomes, Leslie Kate Wright, Paulina Cortez, Margaret A. Franzen, Dina L. Newman

Articles

Many biology students struggle to learn about the process of meiosis and have particular difficulty understanding the molecular basis of crossing over and the importance of homologous pairing for proper segregation. To help students overcome these challenges, we designed an activity that uses a newly developed Chromosome Connections Kit® from 3-D Molecular Designs to allow learners to explore meiosis at the molecular level. We took a backwards design approach in constructing an effective classroom activity. We developed evidence-based learning objectives and designed a crossing over activity that targets students' misconceptions and key concepts about meiosis. Assessment questions were designed based …

Gpr21 Inhibition Increases Glucose-Uptake In Hepg2 Cells, Gemma K. Kinsella, Stefania Cannito, Valentina Bordano, John C. Stephens, Arianna C. Rosa, Gianluca Miglio, Valeria Guaschino, Valeria Iannaccone, John B.C. Findlay, Elisa Benetti

Articles

GPR21 is a constitutively active, orphan, G-protein-coupled receptor, with in vivo studies suggesting its involvement in the modulation of insulin sensitivity. However, its precise contribution is not fully understood. As the liver is both a major target of insulin signalling and critically involved in glucose metabolism, the aim of this study was to examine the role of GPR21 in the regulation of glucose uptake and production in human hepatocytes. In particular, HepG2 cells, which express GPR21, were adopted as cellular models. Compared with untreated cells, a significant increase in glucose uptake was measured in cells treated with siRNA to downregulate …

Is The Net Investment Income Tax A Treaty Override? Reflections On Toulouse, Reuven S. Avi-Yonah

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In this article, AviYonah examines the U.S. Tax Court's judgment in Toulouse that the denial of foreign tax credits against the net investment income tax imposed by the Affordable Care Act was not a violation of U.S. tax treaties with France and Italy and its implications for whether the base erosion and antiabuse tax is a treaty override.

Special Matters: Filtering Privileged Materials In Federal Prosecutions, Christina Frohock

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This Article reviews the U.S. Department of Justice's toolbox for handling potentially privileged materials, with close attention to the evolution from filter teams to the Special Matters Unit in fraud prosecutions. Significant case opinions from the U.S. Courts of Appeals for the Fourth, Sixth, and Eleventh Circuits reveal the judiciary's diverse views on filter teams. The recent case of United States v. Esformes in the U.S. District Court for the Southern District of Florida, now on appeal to the Eleventh Circuit, illustrates how a filter team can fall short and draw unflattering attention to the Department of Justice. In the …

Why Are You Here? Modeling Illicit Massage Business Location Characteristics With Machine Learning, Anna White, Seth Guikema, Bridgette Carr

Articles

Illicit massage businesses are a venue for sex and labor trafficking in the United States. Though many of their locations are made publicly available through online advertising, little is known about why they choose to locate where they do. In this work, we use inferential modeling to better understand the spatial distribution of illicit massage businesses within the U.S. Based on addresses web-scraped weekly from online advertisements over 6 months, we modeled illicit massage business prevalence at the census tract and county levels. We used publicly available data to characterize census tracts and counties, finding that the state in which …

Funding Global Governance, Kristina B. Daugirdas

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Funding is an oft-overlooked but critically important determinant of what public institutions are able to accomplish. This article focuses on the growing role of earmarked voluntary contributions from member states in funding formal international organizations such as the United Nations and the World Health Organization. Heavy reliance on such funds can erode the multilateral governance of international organizations and poses particular risks for two kinds of undertakings: normative work, such as setting standards and identifying best practices; and evaluating the conduct of member states and holding those states accountable, including through public criticism, when they fall short. International organizations have …

Privacy As The Price Of Drug Access, Laura Karas

Articles

In response to the recent increase in FDA-approved specialty drugs and escalating specialty drug prices, drug companies now offer patient support programs ("PSPs") for eligible patients prescribed a particular pharmaceutical drug. Such programs encompass both financial assistance for the purchase of a specialty drug and behavioral services, including nursing support and injection training, intended to improve drug adherence. Although ostensibly gratuitous, these programs have a steep and underappreciated cost: disclosure of protected health information. In effect, patient support programs compel patients to trade protected health information for drug access. This Article provides the first in-depth examination of the legal and …

Friends And Family Matter Most: A Trend Analysis Of Increasing E-Cigarette Use Among Irish Teenagers And Sociodemographic, Personal, Peer And Familial Associations, Joan Hanafin, Salome Sunday, Luke Clancy

Articles

Background

E-cigarette ever-use and current-use among teenagers has increased worldwide, including in Ireland.

Methods

We use data from two Irish waves (2015, 2019) of the European School Survey Project on Alcohol and other Drugs (ESPAD) to investigate gender and teenage e-cigarette use (n = 3421 16-year-olds). Using chi-square analyses, we report changes in e-cigarette ever-use, current-use, and associated variables. Using multivariable logistic regression, we analyse the increase in e-cigarette use and socio-demographic, personal, peer and familial associations, focusing on gender differences.

Results

E-cigarette ever-use increased from 23% in 2015 to 37% in 2019, and current-use from 10 to …

Increased Smoking And E-Cigarette Use Among Irish Teenagers: A New Threat To Tobacco Free Ireland 2025, Salome Sunday, Joan Hanafin, Luke Clancy

Articles

Introduction

Tobacco Free Ireland is an Irish Government policy which demands that the prevalence of tobacco smoking in Ireland be less than 5% by 2025. From 1995 to 2015, teen smoking decreased from 41% in 1995 to 13.1 % in 2015, and SimSmoke modelling suggested that the 5% 2025 target was achievable in that group (1). But, in 2019, current smoking (smoked in the past 30 days) increased overall from 13.1% in 2015 to 14.4% in 2019, with the increase being greater in boys than girls (16.2%) vs (12.8% ) (2). This threatens the Tobacco Free Ireland endgame and we …