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Full-Text Articles in Entire DC Network
Code Review Practices For Refactoring Changes: An Empirical Study On Openstack, Mohamed Wiem Mkaouer, Eman Abdullah Alomar, Moatz Chouchen, Ali Ouni
Code Review Practices For Refactoring Changes: An Empirical Study On Openstack, Mohamed Wiem Mkaouer, Eman Abdullah Alomar, Moatz Chouchen, Ali Ouni
Articles
Modern code review is a widely used technique employed in both industrial and open-source projects to improve software quality, share knowledge, and ensure adherence to coding standards and guidelines. During code review, developers may discuss refactoring activities before merging code changes in the code base. To date, code review has been extensively studied to explore its general challenges, best practices and outcomes, and socio-technical aspects. However, little is known about how refactoring is being reviewed and what developers care about when they review refactored code. Hence, in this work, we present a quantitative and qualitative study to understand what are …
From Zero To Thrive: A Model Of Cross-System And Cross-Sector Relational Health To Promote Early Childhood Development Across The Child-Serving Ecosystem, Alison L. Miller, Sara F. Stein, Rebeccah Sokol, Rachel Varisco, Phoebe Trout, Megan M. Julian, Julie Ribaudo, Joshua B. Kay, Natasha V. Pilkauskas, Nicole Gardner-Neblett, Todd I. Herrenkohl, Kara Zivin, Maria Muzik, Katherine L. Rosenblum
From Zero To Thrive: A Model Of Cross-System And Cross-Sector Relational Health To Promote Early Childhood Development Across The Child-Serving Ecosystem, Alison L. Miller, Sara F. Stein, Rebeccah Sokol, Rachel Varisco, Phoebe Trout, Megan M. Julian, Julie Ribaudo, Joshua B. Kay, Natasha V. Pilkauskas, Nicole Gardner-Neblett, Todd I. Herrenkohl, Kara Zivin, Maria Muzik, Katherine L. Rosenblum
Articles
Early relational health between caregivers and children is foundational for child health and well-being. Children and caregivers are also embedded within multiple systems and sectors, or a “child-serving ecosystem”, that shapes child development. Although the COVID-19 pandemic has made this embeddedness abundantly clear, systems remain siloed and lack coordination. Fostering relational health amongst layers of this ecosystem may be a way to systematically support young children and families who are facing adversity. We integrate theory, examples, and empirical findings to develop a conceptual model informed by infant mental health and public health frameworks that illustrates how relational health across the …
Combining Pharmacokinetics And Vibrational Spectroscopy: Mcr-Als Hard-And-Soft Modelling Of Drug Uptake In Vitro Using Tailored Kinetic Constraints, David Perez-Guaita, Guillermo Quintas, Zeineb Farhane, Roma Tauler, Hugh Byrne
Combining Pharmacokinetics And Vibrational Spectroscopy: Mcr-Als Hard-And-Soft Modelling Of Drug Uptake In Vitro Using Tailored Kinetic Constraints, David Perez-Guaita, Guillermo Quintas, Zeineb Farhane, Roma Tauler, Hugh Byrne
Articles
Raman microspectroscopy is a label-free technique which is very suited for the investigation of pharmacokinetics of cellular uptake, mechanisms of interaction, and efficacies of drugs in vitro. However, the complexity of the spectra makes the identification of spectral patterns associated with the drug and subsequent cellular responses difficult. Indeed, multivariate methods that relate spectral features to the inoculation time do not normally take into account the kinetics involved, and important theoretical information which could assist in the elucidation of the relevant spectral signatures is excluded. Here, we propose the integration of kinetic equations in the modelling of drug uptake and …
Estimating The Analytical Performance Of Raman Spectroscopy For Quantification Of Active Ingredients In Human Stratum Corneum, Hichem Kichou, Emilie Munnier, Yuri Dancik, Kamilia Kemel, Hugh Byrne, Ali Tfayli, Dominique Bertrand, Martin Soucé, Igor Chourpa, Franck Bonnier
Estimating The Analytical Performance Of Raman Spectroscopy For Quantification Of Active Ingredients In Human Stratum Corneum, Hichem Kichou, Emilie Munnier, Yuri Dancik, Kamilia Kemel, Hugh Byrne, Ali Tfayli, Dominique Bertrand, Martin Soucé, Igor Chourpa, Franck Bonnier
Articles
Confocal Raman microscopy (CRM) has become a versatile technique that can be applied routinely to monitor skin penetration of active molecules. In the present study, CRM coupled to multivariate analysis (namely PLSR—partial least squares regression) is used for the quantitative measurement of an active ingredient (AI) applied to isolated (ex vivo) human stratum corneum (SC), using systematically varied doses of resorcinol, as model compound, and the performance is quantified according to key figures of merit defined by regulatory bodies (ICH, FDA, and EMA). A methodology is thus demonstrated to establish the limit of detection (LOD), precision, accuracy, sensitivity (SEN), and …
Controlling Unequal Surface Energy Results Caused By Test Liquids: The Case Of Uv/O3 Treated Pet, Bilge N. Altay, Paul D. Fleming, Md Arifur Rahman, Alexandra Pekarovicova, Bruce Myers, Cem Aydemir, Arif Karademir
Controlling Unequal Surface Energy Results Caused By Test Liquids: The Case Of Uv/O3 Treated Pet, Bilge N. Altay, Paul D. Fleming, Md Arifur Rahman, Alexandra Pekarovicova, Bruce Myers, Cem Aydemir, Arif Karademir
Articles
Ultraviolet/ozone (UV/O3) treatment has been reported to be an effective method to modify properties such as wettability, adhesion or adsorption of plastic surfaces. The change in the surface is measured by contact angle analysis, which employs liquids and their surface tensions (ST) to estimate the surface energy (SE). We found two different practices in the scientific community: (1) the majority of researchers adopted the ST value of liquids from the literature, while (2) other researchers conducted real-time measurements in the lab under ambient conditions prior to SE estimation. To the best of our knowledge, there is no study that compares …
Controlling Unequal Surface Energy Results Caused By Test Liquids: The Case Of Uv/O3 Treated Pet, Bilge N. Altay, Paul D. Fleming, Md Arifur Rahman, Alexandra Pekarovicova, Bruce Myers, Cem Aydemir, Arif Karademir
Controlling Unequal Surface Energy Results Caused By Test Liquids: The Case Of Uv/O3 Treated Pet, Bilge N. Altay, Paul D. Fleming, Md Arifur Rahman, Alexandra Pekarovicova, Bruce Myers, Cem Aydemir, Arif Karademir
Articles
Ultraviolet/ozone (UV/O3) treatment has been reported to be an effective method to modify properties such as wettability, adhesion or adsorption of plastic surfaces. The change in the surface is measured by contact angle analysis, which employs liquids and their surface tensions (ST) to estimate the surface energy (SE). We found two different practices in the scientific community: (1) the majority of researchers adopted the ST value of liquids from the literature, while (2) other researchers conducted real-time measurements in the lab under ambient conditions prior to SE estimation. To the best of our knowledge, there is no study that compares …
In The Garden: Capacities That Contribute To Community Groups Establishing Community Gardens,, Gerard Doyle
In The Garden: Capacities That Contribute To Community Groups Establishing Community Gardens,, Gerard Doyle
Articles
Based on case studies in Dublin, Ireland, this paper examines the motives for individuals to establish community gardens therein. The paper also outlines the capacities required for community groups to successfully establish and sustain community gardens in Ireland. These capacities include the involvement of individuals with a range of expertise, the presence of supportive community groups/organisations and state agencies, and access to resources, including land. The research findings, detailed in this paper, indicate that community gardens in urban settings encounter a number of challenges, including the absence of a mechanism for community groups to access land. The article provides a …
Active Leisure And Ageing In Rural Ireland: Exploring Perceptions And Motivations To Facilitate And Promote Meaningful Physical Activity, Angie Hartnett, Catherine Gorman
Active Leisure And Ageing In Rural Ireland: Exploring Perceptions And Motivations To Facilitate And Promote Meaningful Physical Activity, Angie Hartnett, Catherine Gorman
Articles
The life expectancy of the world population is increasing and the art of aging well is of global interest (European Commission, n.d.). In Ireland, the number of people over the age of 60 will increase from 1.1 million currently, to 2.44 million by 2041, constituting nearly one third of its total population (Institute of Public Health, 2018). Despite the benefits of regular physical activity (pa), particularly with the frail (≥65 years and requiring a walking aid), rates of participation remain low (Colley et al., 2011). Health concerns raised, such as smoking and weight issues, are more prevalent in this cohort …
Lawyering The Presidency, Deborah Pearlstein
Lawyering The Presidency, Deborah Pearlstein
Articles
Among its many profound effects on American life, the Trump presidency has triggered a surge of interest in the project of law reform to better check the exercise of presidential power. Yet these reform efforts arise against a wholly unsettled debate about the function and effectiveness of existing checks, perhaps none more so than the role of executive branch legal counsel. With courts often deferential, and Congress hamstrung by partisan polarization, scholars have drawn on the experiences of executive branch lawyers to assess whether counsel functions as part of an “internal separation of powers” form of constraint. Yet while these …
Disaggregating Slavery And The Slave Trade, Jocelyn Getgen Kestenbaum
Disaggregating Slavery And The Slave Trade, Jocelyn Getgen Kestenbaum
Articles
International law prohibits slavery and the slave trade as peremptory norms, customary international law prohibitions and crimes, humanitarian law prohibitions, and non-derogable human rights. Human rights bodies, however, focus on human trafficking, even when slavery and the slave trade—and not human trafficking—are enumerated within their mandates. International human rights law has conflated human trafficking with slavery and the slave trade. Consequently, human trafficking has subsumed the slave trade and, at times, slavery prohibitions, increasing perpetrator impunity for slavery and the slave trade abuses and denying full expressive justice to survivors.
This Article disaggregates slavery from the slave trade and slavery …
Is Bitcoin Prudent? Is Art Diversified? Offering Alternative Investments To 401(K) Participants, Edward A. Zelinsky
Is Bitcoin Prudent? Is Art Diversified? Offering Alternative Investments To 401(K) Participants, Edward A. Zelinsky
Articles
Whether 401(k) plans’ investment menus should feature “alternative” investments is a fact-driven inquiry applying ERISA’s fiduciary standards of prudence, loyalty, and diversification. Central to this fact-driven inquiry is whether the alternative investment class in question is broadly accepted by investors in general and by professional defined benefit trustees in particular. A similarly salient concern when making this inquiry is the financial unsophistication of many, perhaps most, 401(k) participants. Accounting for these considerations, this Article concludes that REITs, private equity funds, and hedge funds can, with limits, today be offered as investment choices to 401(k) participants, but that cryptocurrencies (including Bitcoin), …
The Progressive Love Affair With The Carceral State, Kate Levine
The Progressive Love Affair With The Carceral State, Kate Levine
Articles
A Review of The Feminist War on Crime: The Unexpected Role of Women’s Liberation in Mass Incarceration. By Aya Gruber.
Vacuum Uv (Vuv) Photo-Oxidation Of Polyethersulfone (Pes), Sarah Oakes, Ryan Keeley, Hunter Heineman, Tom Allston, Joel Shertok, Michael Mehan, Gregory K. Thompson, Gerald A. Takacs
Vacuum Uv (Vuv) Photo-Oxidation Of Polyethersulfone (Pes), Sarah Oakes, Ryan Keeley, Hunter Heineman, Tom Allston, Joel Shertok, Michael Mehan, Gregory K. Thompson, Gerald A. Takacs
Articles
International need for water quality is placing a high demand on separation technology to develop advanced oxidative processes for polyethersulfone (PES) membranes to help improve water purification. Therefore, VUV photo-oxidation with a low pressure Ar plasma was studied to improve the hydrophilicity of PES by flowing oxygen over the surface during treatment. X-ray photoelectron spectroscopy (XPS) detected a decrease in the C at% (4.4 ± 1.7 at%), increase in O at% (3.7 ± 1.0 at%), and a constant S at% (5.4 ± 0.2 at%). Curve fitting of the XPS spectra showed a decrease in sp2 C-C aromatic group bonding, and …
Judicial Impartiality In The Judicial Council Act 2019: Challenges And Opportunities, Brian M. Barry Dr
Judicial Impartiality In The Judicial Council Act 2019: Challenges And Opportunities, Brian M. Barry Dr
Articles
The Judicial Council is tasked with promoting and maintaining high standards of judicial conduct. The Judicial Council Act 2019 identifies judicial impartiality as a principle of judicial conduct that Irish judges are required to uphold and exemplify. Despite its ubiquity, judicial impartiality is perhaps under-explained and under-examined.
This article considers the nature and scope of judicial impartiality in contemporary Irish judging. It argues that the Judicial Council ought to take a proactive, multi-faceted approach to promote and maintain judicial impartiality, to address contemporary challenges that the Irish judiciary face including increasingly sophisticated empirical research into judicial performance, the proliferation of …
Big Data Analysis Of Vision Screening Standards Used To Evaluate Fitness To Drive, Michael Moore, John Butler, Daniel Ian Flitcroft, James Loughman
Big Data Analysis Of Vision Screening Standards Used To Evaluate Fitness To Drive, Michael Moore, John Butler, Daniel Ian Flitcroft, James Loughman
Articles
Purpose: Visual acuity (VA) assessment is the most commonly performed vision screening method for drivers. The standards and repeat assessment intervals used, however, are arbitrary, lack an evidence base and are highly variable across different countries. This study utilizes the power of Big Data to provide evidence-based recommendations for standardized driver vision screening.
Methods: Anonymized electronic medical record data were gathered from 40 Irish optometry practices comprising 81,184 unique patients. A Kaplan-Meier Survival (KMS) analysis was used to determine the effect of increasing age and time since screening on the likelihood of passing the VA standard for driving. A logistic …
Detecting Iot Attacks Using An Ensemble Machine Learning Model, Vikas Tomar, Sachin Sharma
Detecting Iot Attacks Using An Ensemble Machine Learning Model, Vikas Tomar, Sachin Sharma
Articles
Malicious attacks are becoming more prevalent due to the growing use of Internet of Things (IoT) devices in homes, offices, transportation, healthcare, and other locations. By incorporating fog computing into IoT, attacks can be detected in a short amount of time, as the distance between IoT devices and fog devices is smaller than the distance between IoT devices and the cloud. Machine learning is frequently used for the detection of attacks due to the huge amount of data available from IoT devices. However, the problem is that fog devices may not have enough resources, such as processing power and memory, …
Technological Efforts, Firm Ownership And Productivity: A Study Of Information Technology Service Firms In India, Asmita Goswami, K. Narayanan
Technological Efforts, Firm Ownership And Productivity: A Study Of Information Technology Service Firms In India, Asmita Goswami, K. Narayanan
Articles
The article presents differences in firm-level total factor productivity in the information technology (IT) service firms in India over the period 2000–2016. It is an attempt to study whether technological efforts contribute to productivity differences in the firms in conjunction with several other firm specific characteristics. Controlling for endogeneity in inputs, the estimation of productivity through semi-parametric techniques indicates considerable heterogeneity in productivity across firm types. Technological efforts of firms have a significant impact on the productivity of IT firms. Both embodied technology imports and in-house R&D contribute to higher productivity. While the Indian firms are observed to be more …
Assessment Of Consumer Protection Act 2019 To Support Tobacco Control In India, Ashok R. Patil
Assessment Of Consumer Protection Act 2019 To Support Tobacco Control In India, Ashok R. Patil
Articles
The use of tobacco products has been clearly established to cause significant medical and economic harm. While specific tobacco control legislation has been enacted in the form of the COTPA 2003, it is important to examine if other legislations can be utilised for regulation of tobacco consumption. One such legislation is the Consumer Protection Act 2019, which significantly expands the rights of consumers and protection given to them in terms of product safety and product quality. Accordingly, this paper provides an in-depth analysis of the Consumer Protection Act 2019 and the scope of utilising this legislation and the jurisprudence on …
Including Autistic Teens In Libraries, Aisling Smith
Including Autistic Teens In Libraries, Aisling Smith
Articles
This article discusses the needs of autistic teenagers with low support needs and how best to cultivate and promote inclusivity in libraries to better serve this vulnerable sector of the community. Librarians should endeavour to understand the difficulties they encounter and how to minimize factors that might exacerbate these issues if autistic adolescents are to feel welcome and accepted.
Towards An Ethical Framework For The Design And Development Of Inclusive Home-Based Smart Technology For Smart Spaces For Older Adults And People With Disabilities, Emma Murphy, Julie Doyle, Ioannis Stavrakakis, Damian Gordon, Brian Keegan, Dympna O'Sullivan
Towards An Ethical Framework For The Design And Development Of Inclusive Home-Based Smart Technology For Smart Spaces For Older Adults And People With Disabilities, Emma Murphy, Julie Doyle, Ioannis Stavrakakis, Damian Gordon, Brian Keegan, Dympna O'Sullivan
Articles
Unique ethical, privacy and safety implications arise for people who are reliant on home-based smart technology due to health conditions or disabilities. As a result we need to carefully reflect on our approaches to ethical issues over the life cycle of smart home technology design and the wider living context for end users and relevant stakeholders. In this position paper we highlight a need for a reflective, inclusive ethical framework for the design of inclusive smart spaces. We present key ethical considerations in the design, development and deployment of smart home-based technology for older adults and people with disabilities. We …
Age Specific Models To Capture The Change In Risk Factor Contribution By Age To Short Term Primary Ischemic Stroke Risk, Elizabeth Hunter, John D. Kelleher
Age Specific Models To Capture The Change In Risk Factor Contribution By Age To Short Term Primary Ischemic Stroke Risk, Elizabeth Hunter, John D. Kelleher
Articles
Age is one of the most important risk factors when it comes to stroke risk prediction. However, including age as a risk factor in a stroke prediction model can give rise to a number of difficulties. Age often dominates the risk score, and also not all risk factors contribute proportionally to stroke risk by age. In this study we investigate a number of common stroke risk factors, using Framingham heart study data from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center to determine if they appear to contribute proportionally by age to a stroke risk score. As we …
How Is Immigrant Entrepreneurial Opportunity Formation Influenced By Interactions Between Home And Host Countries?, Kingsley C. Njoku, Thomas M. Cooney
How Is Immigrant Entrepreneurial Opportunity Formation Influenced By Interactions Between Home And Host Countries?, Kingsley C. Njoku, Thomas M. Cooney
Articles
This study examined how the entrepreneurial opportunity formation process among different ethnic groups was influenced by their origins and the cultural values accustomed to them. Using a qualitative phenomenological approach, data was collected from 20 participants (five each from four different ethnic groups) using an in-depth interview technique. The study found that the interactions between an immigrant's home and host environments can take different forms (i.e., enablers and threats) which will influence their career choices in diverse ways. The study model framework showed that participants are influenced distinctly subject to their ethnic backgrounds and the nature of their interactions with …
In Vitro Toxicological Evaluation Of Mesoporous Silica Microparticles Functionalised 1 With Carvacrol And Thymol, Cristina Fuentes, Ana Fuentes, Hugh Byrne, José Barat, María José Ruiz
In Vitro Toxicological Evaluation Of Mesoporous Silica Microparticles Functionalised 1 With Carvacrol And Thymol, Cristina Fuentes, Ana Fuentes, Hugh Byrne, José Barat, María José Ruiz
Articles
The cytotoxicity of carvacrol- and thymol- functionalised mesoporous silica microparticles (MCM-41) was assessed in the human hepatocarcinoma cell line (HepG2). Cell viability, lactate dehydrogenase (LDH) activity, reactive oxygen species (ROS) production, mitochondrial membrane potential (ΔΨm), lipid peroxidation (LPO) and apoptosis/necrosis analysis were used as endpoints. Results showed that both materials induced cytotoxicity in a time and concentration-dependent manner, being more cytotoxic than free essential oil components and bare MCM-41. This effect was caused by the cell-particle interactions and not from degradation products released to the culture media, as demonstrated in the extract dilution assays. LDH release was seen to be …
Extracellular Secretion Of A Cutinase With Polyester-Degrading Potential By E. Coli Using A Novel Signal Peptide From Amycolatopsis Mediterranei, Yeqi Tan, Gemma K. Kinsella, Gary T. Henehan, Barry J. Ryan
Extracellular Secretion Of A Cutinase With Polyester-Degrading Potential By E. Coli Using A Novel Signal Peptide From Amycolatopsis Mediterranei, Yeqi Tan, Gemma K. Kinsella, Gary T. Henehan, Barry J. Ryan
Articles
Recent studies in this laboratory showed that an extracellular cutinase from A. mediterranei (AmCut) was able to degrade the plastics polycaprolactone and polybutylene succinate. Such plastics can be slow to degrade in soils due to a lack of efficient polyester degrading organisms. AmCut also showed potential for the biocatalytic synthesis of esters by reverse hydrolysis.
The gene for AmCut has an upstream leader sequence whose transcript is not present in the purified enzyme. In this study, we show using predictive modelling, that this sequence codes for an N-terminal signal peptide that directs transmembrane expression via the Sec secretion pathway.
E. …
Detecting Patches On Road Pavement Images Acquired With 3d Laser Sensors Using Object Detection And Deep Learning, Syed Ibrahim Hassan, Dympna O'Sullivan, Susan Mckeever, Kieran Feighan, David Power, Ray Mcgowan
Detecting Patches On Road Pavement Images Acquired With 3d Laser Sensors Using Object Detection And Deep Learning, Syed Ibrahim Hassan, Dympna O'Sullivan, Susan Mckeever, Kieran Feighan, David Power, Ray Mcgowan
Articles
Regular pavement inspections are key to good road maintenance and road defect corrections. Advanced pavement inspection systems such as LCMS (Laser Crack Measurement System) can automatically detect the presence of different defects using 3D lasers. However, such systems still require manual involvement to complete the detection of pavement defects. This paper proposes an automatic patch detection system using object detection technique. To our knowledge, this is the first time state-of-the-art object detection models Faster RCNN, and SSD MobileNet-V2 have been used to detect patches inside images acquired by LCMS. Results show that the object detection model can successfully detect patches …
The Meld Model: The Holy Grail Of Indian Corporate Jurisprudence, Rahul Singh
The Meld Model: The Holy Grail Of Indian Corporate Jurisprudence, Rahul Singh
Articles
Is a model of a theory of Indian corporate jurisprudence effable? This paper posits that jurisprudence of Indian corporate law is desirable and possible. Given the relative nascence of the Companies Act 2013, Insolvency and Bankruptcy Code 2016 and the Competition Act 2002, this paper undergirds the possibility of jurisprudence through modelling-the meld model-which is, jurisprudentially speaking, a synthesis between 'exclusive legal positivism' and 'law and economics'. The paper instantiates the utility and desirability of the meld model through test suites - i.e. select case laws in the context of company, competition and insolvency laws. With the help of test …
Improving Interpreters’ Normative Ethics Discourse By Imparting Principled-Reasoning Through Case Analysis, Robyn K. Dean, Robert Q. Pollard Jr.
Improving Interpreters’ Normative Ethics Discourse By Imparting Principled-Reasoning Through Case Analysis, Robyn K. Dean, Robert Q. Pollard Jr.
Articles
The vocabulary available to community interpreters regarding professional ethics is typically limited to a set of prohibitions—what interpreters should not do. These prohibitions are disproportionately more prevalent in ethical documents and discourse than guidance on what interpreters should do. Both types of guidance are examples of normative ethical messages. However, when interpreters are asked to justify decisions which lead to them taking action rather than refraining from action, they are left with insufficient vocabulary to do so. Without a broader normative vocabulary allowing conversation regarding action-taking, interpreters tend to rely on unhelpful, non-normative language such as metaphors which fail to …
Effects Of Religiosity And Travel Desire On Covid-19 Vaccination Intentions, Muhammet Kesgin, Ali Selcuk Can, Dogan Gursoy, Yuksel Ekinci, Khaled Aldawodi
Effects Of Religiosity And Travel Desire On Covid-19 Vaccination Intentions, Muhammet Kesgin, Ali Selcuk Can, Dogan Gursoy, Yuksel Ekinci, Khaled Aldawodi
Articles
Despite the deadly consequences of the COVID-19 pandemic, vaccine hesitation remains a threat to public health and international travel. This study tests the effect of Muslim religiosity on belief-based attitudes (i.e., subjective norms, perceived behavioural control) and travel desire as a proxy for COVID-19 vaccination intentions. The structural model was tested using PLS-SEM with the data collected via a self-administrated survey between April and June 2021 in Saudi Arabia (N=759). Results reveal that travel desire along with belief-based attitudes influence COVID-19 vaccination intentions. Intrinsic religiosity influences individuals’ subjective norms, directly and perceived behavioural control and COVID-19 vaccination intentions indirectly through …
Refactoring For Reuse: An Empirical Study, Eman Abdullah Alomar, Tianjia Wang, Vaibhavi Raut, Mohamed Wiem Mkaouer, Christian D. Newman, Ali Ouni
Refactoring For Reuse: An Empirical Study, Eman Abdullah Alomar, Tianjia Wang, Vaibhavi Raut, Mohamed Wiem Mkaouer, Christian D. Newman, Ali Ouni
Articles
Refactoring is the de-facto practice to optimize software health. While several studies propose refactoring strategies to optimize software design through applying design patterns and removing design defects, little is known about how developers actually refactor their code to improve its reuse. Therefore, we extract, from 1,828 open source projects, a set of refactorings that were intended to improve the software reusability. We analyze the impact of reusability refactorings on the state-of-the-art reusability metrics, and we compare the distribution of reusability refactoring types, with the distribution of the remaining mainstream refactorings. Overall, we found that the distribution of refactoring types, applied …
Plasma Induced Reactive Oxygen Species-Dependent Cytotoxicity In Glioblastoma 3d Tumourspheres, Janith Wanigasekara, Carlos Barcia, Patrick J. Cullen, Brijesh Tiwari, James F. Curtin
Plasma Induced Reactive Oxygen Species-Dependent Cytotoxicity In Glioblastoma 3d Tumourspheres, Janith Wanigasekara, Carlos Barcia, Patrick J. Cullen, Brijesh Tiwari, James F. Curtin
Articles
The aim of this study was to determine the effects of a pin‐to‐plate cold atmospheric plasma (CAP) on U‐251 MG three‐dimensional (3D) glioblastoma spheroids under different conditions. 3D tumorspheres showed higher resistance to the CAP treatment compared to 2D monolayer cells. A single CAP treatment was able to induce cytotoxicity, while multiple CAP treatments augmented this effect. CAP was also able to induce cytotoxicity throughout the tumoursphere, and we identified that reactive oxygen species(ROS) plays a major role, while H2O2plays a partial role in CAP‐induced cytotoxicity in tumour-spheres. We conclude that ROS‐dependent cytotoxicity is induced uniformly throughout glioblastoma and epidermoid …