Digital Commons Network^™

Lightgwas: A Novel Machine Learning Procedure For Genome-Wide Association Study, Ambrozio Bruno, Luca Longo, Lucas Rizzo

Articles

This paper proposes a novel machine learning procedure for genome-wide association study (GWAS), named LightGWAS. It is based on the LightGBM framework, in addition to being a single, resilient, autonomous and scalable solution to address common limitations of GWAS implementations found in the literature. These include reliance on massive manual quality control steps and specific GWAS methods for each type of dataset morphology and size. Through this research, LightGWAS has been contrasted against PLINK2, one of the current state-of-the-art for GWAS implementations based on general linear model with support to firth regularisation. The mean differences measured upon standard classification metrics, …

A Conceptual Model To Explain Dark Matter And Dark Energy, Jonathan Blackledge

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This paper considers a conceptual model that attempts to explain ‘Dark Matter’ and‘Dark Energy’. The model is based on considering a gravitational field to be the result of a mass (aHiggs field) scattering pre-existing cosmic background space-time waves or ‘Uber-waves’. The term‘Uber’ is used to denote an outstanding or supreme example of a particular kind of gravitationalwave with cosmic-scale wavelengths that are far in excess of those associated with the gravitationalwaves generated by accelerating masses. Such waves are taken to be the very lowest frequencycomponents associated with the spectrum of space-time waves generated by the ‘Big Bang’ andare supported by …

Exploring The Potential Of Defeasible Argumentation For Quantitative Inferences In Real-World Contexts: An Assessment Of Computational Trust, Lucas Rizzo, Pierpaolo Dondio, Luca Longo

Articles

Argumentation has recently shown appealing properties for inference under uncertainty and conflicting knowledge. However, there is a lack of studies focused on the examination of its capacity of exploiting real-world knowledge bases for performing quantitative, case-by-case inferences. This study performs an analysis of the inferential capacity of a set of argument-based models, designed by a human reasoner, for the problem of trust assessment. Precisely, these models are exploited using data from Wikipedia, and are aimed at inferring the trustworthiness of its editors. A comparison against non-deductive approaches revealed that these models were superior according to values inferred to recognised trustworthy …

Brightness Matching In Optical See-Through Augmented Reality, Michael Murdoch

Articles

A visual experiment using a beam-splitter-based optical see-through augmented reality (OST-AR) setup tested the effect of the size and alignment of AR overlays with a brightness-matching task using physical cubes. Results indicate that more luminance is required whenARoverlays are oversized with respect to the cubes, showing that observers discount theARoverlay to a greater extent when it is more obviously a transparent layer. This is not explained by conventional color appearance modeling but supports an AR-specific model based on foreground-background discounting. The findings and model will help determine parameters for creating convincingARmanipulation of realworld objects.

The Behavioral Effects Of (Unenforceable) Contracts, Evan Starr, Jj Prescott, Norman Bishara

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Do contracts influence behavior independent of the law governing their enforceability? We explore this question in the context of employment noncompetes using nationally representative data for 11,500 labor force participants. We show that noncompetes are associated with reductions in employee mobility and changes in the direction of that mobility (i.e., toward noncompetitors) in both states that do and do not enforce noncompetes. Decomposing mobility into job offer generation and acceptance, we detect no evidence of differences in job search, recruitment, or offer activity associated with noncompetes. Rather, we find that employees with noncompetes—even in states that do not enforce them—frequently …

Towards An Urban Disability Agenda, Samuel R. Bagenstos

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The overwhelming majority of Americans with disabilities live in metropolitan areas. Yet those areas continue to contain significant barriers that keep disabled people from fully participating in city life. Although political and social debate has periodically turned its attention to urban issues or problems — or even the so-called “urban crisis” — during the past several decades, it has too rarely attended to the issues of disability access. When political debate has focused on disability issues, it has tended to address them in a nationally uniform way, without paying attention to the particular concerns of disabled people in cities. Even …

The Executive Branch Anticanon, Deborah Pearlstein

Articles

Donald Trump’s presidency has given rise to a raft of concerns not just about the wisdom of particular policy decisions but also about the prospect that executive actions might have troubling longer term “precedential” effects. While critics tend to leave undefined what “precedent” in this context means, existing constitutional structures provide multiple mechanisms by which presidential practice can influence future executive branch conduct: judicial actors rely on practice as gloss on constitutional meaning, executive branch officials rely on past practice in guiding institutional norms of behavior, and elected officials outside the executive branch and the people themselves draw on past …

A Hybrid Agent-Based And Equation Based Model For The Spread Of Infectious Diseases, Elizabeth Hunter, Brian Mac Namee, John D. Kelleher

Articles

Both agent-based models and equation-based models can be used to model the spread of an infectious disease. Equation-based models have been shown to capture the overall dynamics of a disease outbreak while agent-based models are able to capture heterogeneous characteristics of agents that drive the spread of an outbreak. However, agent-based models are computationally intensive. To capture the advantages of both the equation-based and agent-based models, we create a hybrid model where the disease component of the hybrid model switches between agent-based and equation-based. The switch is determined using the number of agents infected. We first test the model at …

Riluzole Attenuates Glutamatergic Tone And Cognitive Decline In Aβpp/Ps1 Mice., Kevin N Hascup, Caleigh A Findley, Jesse Britz, Nahayo Esperant-Hilaire, Sarah O Broderick, Kristin Delfino, Shelley Tischkau, Andrzej Bartke, Erin R Hascup

Articles

We have previously demonstrated hippocampal hyperglutamatergic signaling occurs prior to plaque accumulation in AβPP/PS1 mice. Here, we evaluate 2-Amino-6-(trifluoromethoxy) benzothiazole (riluzole) as an early intervention strategy for Alzheimer's disease (AD), aimed at restoring glutamate neurotransmission prior to substantial Beta amyloid (Aβ) plaque accumulation and cognitive decline. Male AβPP/PS1 mice, a model of progressive cerebral amyloidosis, were treated with riluzole from 2-6 months of age. Morris water maze, in vivo electrochemistry, and immunofluorescence were performed to assess cognition, glutamatergic neurotransmission, and pathology, respectively, at 12 months. Four months of prodromal riluzole treatment in AβPP/PS1 mice resulted in long-lasting procognitive effects and …

Comparing Variable Importance In Prediction Of Silence Behaviours Between Random Forest And Conditional Inference Forest Models., Stephen Barrett Dr, Geraldine Gray Dr, Colm Mcguinness Dr, Michael Knoll Dr.

Articles

This paper explores variable importance metrics of Conditional Inference Trees (CIT) and classical Classification And Regression Trees (CART) based Random Forests. The paper compares both algorithms variable importance rankings and highlights why CIT should be used when dealing with data with different levels of aggregation. The models analysed explored the role of cultural factors at individual and societal level when predicting Organisational Silence behaviours.

Assessment And Evaluation Of Student Learning Through A Project-Based Assignment On Note By Note Cooking, Roisin Burke, Pauline Danaher

Articles

Many innovative teaching and learning methods are used in higher level education including projectbased learning (PBL). Since 2012 a PBL assignment project has been undertaken by master students of the Advanced Molecular Gastronomy module at Technological University Dublin (TU Dublin). The aim is to stimulate student learning and creativity by using Note by Note cooking in a PBL assignment while at the same time complying with the requirements of the annual International Note by Note contest which is held in Paris, France. Direct and indirect assessment methods were used to assign individual grades and to gather student feedback about the …

Investigation Of Surrogate Biomarkers Associated With Macular Pigment Status In A Group Of Older Irish Adults, Grainne Scanlon, John S. Butler, Daniel Mccartney, Ekaterina Lostutova, Rose Anne Kenny, James Loughman

Articles

SIGNIFICANCE: Macular pigment (MP) confers potent antioxidant and anti-inflammatory effects at the macula; however, its optical density in the eye is not routinely measured in clinical practice.

PURPOSE: This study explored a range of surrogate biomarkers including anthropometric, clinical, and plasma measures that may be associated with lower MP optical density (MPOD).

METHODS: Two thousand five hundred ninety-four subjects completed a full MP assessment as part of wave 1 of The Irish Longitudinal Study of Aging. Macular pigment optical density was measured using customized heterochromatic flicker photometry. Clinical (blood pressure), plasma (lipoproteins, inflammatory markers), and anthropometric (waist, hip, height, weight) …

An Examination Of Enhanced Atmospheric Methane Detection Methods For Predicting Performance Of A Novel Multiband Uncooled Radiometer Imager, Cody M. Webber, John P. Kerekes

Articles

To evaluate the potential for a new uncooled infrared radiometer imager to detect enhanced atmospheric levels of methane, three different analysis methods were examined. A single-pixel brightness temperature to noise-equivalent delta temperature (NEdT) comparison study performed using data simulated from MODTRAN6 revealed that a single thermal band centered on the 7.68 µm methane feature leads to a detectable brightness temperature difference exceeding the sensor noise level for a plume of about 17 ppm at ambient atmospheric temperature compared to an ambient plume with no enhanced methane present. Application of a normalized differential methane index method, a novel approach for methane …

An Examination Of Enhanced Atmospheric Methane Detection Methods For Predicting Performance Of A Novel Multiband Uncooled Radiometer Imager, Cody M. Webber, John Kerekes

Articles

To evaluate the potential for a new uncooled infrared radiometer imager to detect enhanced atmospheric levels of methane, three different analysis methods were examined. A single-pixel brightness temperature to noise-equivalent delta temperature (NEdT) comparison study performed using data simulated from MODTRAN6 revealed that a single thermal band centered on the 7.68 µm methane feature leads to a detectable brightness temperature difference exceeding the sensor noise level for a plume of about 17 ppm at ambient atmospheric temperature compared to an ambient plume with no enhanced methane present. Application of a normalized differential methane index method, a novel approach for methane …

Study On The Influence Of Road Geometry On Vehicle Lateral Instability, Yanna Yin, Huiying Wen, Lu Sun, Wei Hou

Articles

According to the accident analysis of vehicles in the curve, the skidding, rollover, and lateral drift of vehicles are determined as means to evaluate the lateral stability of vehicles. -e utility truck of rear-wheel drive (RWD) is researched, which is high accident rate. Human-vehicle-road simulation models are established by CarSim. -rough the orthogonal experiment method, the effects of different road geometries, speed, and interaction factors between road geometries on vehicle lateral stability are studied. In this paper, skidding risk of the vehicle is characterized by the Side-way Force Coefficient (SFC). Rollover risk of the vehicle is characterized by lateral acceleration …

Aesthetics, Culture, Power Critical Deaf Pedagogy And Asl Video-Publications As Resistance-To-Audism In Deaf Education And Research, Michael E. Skyer, Laura Cochell

Articles

From a critical pedagogy standpoint, we examined a bilingual (American Sign Language [ASL] and English) video-publication titled “Seizing Academic Power.” The video-publication explores interactions of power and knowledge in deaf education and research and proposes tools to subvert ableism and deficit ideologies within them. By centralizing multiple visuospatial modalities, the video-publication’s medium is also its message. Qualitative data were produced and analyzed via structured coding cycles then interpreted through two theoretical frameworks focused on culture and aesthetics in critical pedagogy. Our analysis highlights conflicts at the nexus of ontology, epistemology, axiology, and methodology of deaf education and research. Findings reveal …

Arizona's Sex Offender Laws: Recommendations For Reform, Tamara Rice Lave

Articles

No abstract provided.

Children’S Ethno-National Flag Categories In Three Divided Societies, Edona Maloku, Jocelyn B. Dautel, Ana Tomovska Misoska, Laura K. Taylor

Articles

Flags are conceptual representations that can prime nationalism and allegiance to one’s group. Investigating children’s understanding of conflict-related ethno-national flags in divided societies sheds light on the development of national categories. We explored the development of children’s awareness of, and preferences for, ethno-national flags in Northern Ireland, Kosovo, and the Republic of North Macedonia. Children displayed early categorization of, and ingroup preferences for, ethno-national flags. By middle-childhood, children’s conflict-related social categories shaped systematic predictions about other’s group-based preferences for flags. Children of minority-status groups demonstrated more accurate flag categorization and were more likely to accurately infer others’ flag preferences. While …

On Sexual Harassment In The Judiciary, Leah Litman, Deeva Shah

Articles

This Essay examines the legal profession’s role in sexual harassment, particularly in the federal courts. It argues that individuals in the profession have both an individual and collective responsibility for the professional norms that have allowed harassment to happen with little recourse for the people subject to the harassment. It suggests that the legal profession should engage in a sustained, public reflection about how our words, actions, attitudes, and institutional arrangements allow harassment to happen, and about the many different ways that we can prevent and address harassment.

The Support-Or-Advocacy Clauses, Richard Primus, Cameron O. Kistler

Articles

Two little known clauses of a Reconstruction-era civil rights statute are potentially powerful weapons for litigators seeking to protect the integrity of federal elections. For the clauses to achieve their potential, however, the courts will need to settle correctly a contested question of statutory interpretation: do the clauses create substantive rights, or do they merely create remedies for substantive rights specified elsewhere? The correct answer is that the clauses create substantive rights.

Cleanpage: Fast And Clean Document And Whiteboard Capture, Jane Courtney

Articles

The move from paper to online is not only necessary for remote working, it is also significantly more sustainable. This trend has seen a rising need for the high-quality digitization of content from pages and whiteboards to sharable online material. However, capturing this information is not always easy nor are the results always satisfactory. Available scanning apps vary in their usability and do not always produce clean results, retaining surface imperfections from the page or whiteboard in their output images. CleanPage, a novel smartphone-based document and whiteboard scanning system, is presented. CleanPage requires one button-tap to capture, identify, crop, and …

Symposium: The California Consumer Privacy Act, Margot Kaminski, Jacob Snow, Felix T. Wu, Justin Hughes

Articles

This symposium discussion of the Loyola of Los Angeles Law Review focuses on the newly enacted California Consumer Privacy Act (CPPA), a statute signed into state law by then-Governor Jerry Brown on June 28, 2018 and effective as of January 1, 2020. The panel was held on February 20, 2020.

The panelists discuss how businesses are responding to the new law and obstacles for consumers to make effective use of the law’s protections and rights. Most importantly, the panelists grapple with questions courts are likely to have to address, including the definition of personal information under the CCPA, the application …

Nicholas C. Howson's Tribute To Professor William P. Alford, Nicholas C. Howson

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No abstract provided.

Compassion: The Necessary Foundation To Reunify Families Involved In The Foster Care System, Katherine Markey, Vivek Sankaran

Articles

Compassion plays a critical role in ensuring that stakeholders can engage with, and support parents trying to reunify with kids in the foster care system. This Article will explore the compassion crisis in foster care, will present the research documenting the impact of compassion on engaging families, and will identify key steps stakeholders can take to incorporate compassion into their work.

Simulation Of Internet Of Things Water Management For Efficient Rice Irrigation In Rwanda, Peace Bamurigire, Anthony Vodacek, Andras Valko, Said Rutabayiro Ngoga

Articles

The central role of water access for agriculture is a clear challenge anywhere in the world and particularly in areas with significant seasonal variation in rainfall such as in Eastern and Central Africa. The combination of modern sensor technologies, the Internet, and advanced irrigation equipment combined in an Internet of Things (IoT) approach allow a relatively precise control of agricultural irrigation and creating the opportunity for high efficiency of water use for agricultural demands. This IoT approach can thereby increase the resilience of agricultural systems in the face of complex demands for water use. Most previous works on agricultural IoT …

A Lexical Frequency Analysis Of Irish Sign Language, Robert G. Smith, Markus Hofmann

Articles

Word frequency has a significant impact on language acquisition and fluency. It is often a point of reference for the teaching and assessing of a language and indeed, as a control for psycholinguistic studies. This paper presents the results of the first objective frequency analysis of lexical tokens from the Signs of Ireland corpus. We investigate the frequency of fully lexical, partly lexical and non-lexical signs in Irish Sign Language as they are presented in the corpus. We confirm the accuracy of the lexical gloss frequency data with a supplementary corpus subset that is tagged for grammatical class and additional …

Lawyers Democratic Dysfunction, Leah Litman

Articles

As part of the symposium on Jack Balkin and Sandy Levinson’s Democracy and Dysfunction, this Article documents another source of the dysfunction that the authors observe—elite lawyers’ unwillingness to break ranks with other elite lawyers who participate in the destruction of various norms that are integral to a well-functioning democracy. These network effects eliminate the possibility of “soft” sanctions on norm violators such as withholding future professional advancement. Thus, rather than enforcing norms and deterring norm violations, the networks serve to insulate norm violators from any meaningful accountability.

A Positive Dialectic: Beps And The United States, Reuven S. Avi-Yonah

Articles

This essay addresses the interaction between the changes in the international tax regime identified by Mason and U.S. international tax policy. Specifically, I will argue that contrary to the general view, the United States actively implemented the Organisation for Economic Co-Operation and Development (OECD)/G20 Base Erosion and Profit Shifting (BEPS) recommendations through the Tax Cuts and Jobs Act of 2017 (TCJA). Moreover, the changes of the TCJA influenced the current OECD effort of BEPS 2.0. Thus, the current state of affairs can be characterized as a constructive dialogue: The OECD moves (BEPS 1), the United States responds (TCJA), the OECD …

Herein Of 'Herein Granted': Why Article I'S Vesting Clause Does Not Support The Doctrine Of Enumerated Powers, Richard A. Primus

Articles

Article I of the United States Constitution begins as follows: “All legislative Powers herein granted shall be vested in a Congress of the United States[.]” That text is sometimes called the Vesting Clause, or, more precisely, the Article I Vesting Clause, because Articles II and III also begin with Vesting Clauses. And there is a feature of those three clauses, when compared, to which twenty-first century constitutional lawyers commonly attribute considerable significance. Although the three Clauses are similar in other ways, the syntax of Article I’s Vesting Clause is not fully parallel to that of the other two. The Vesting …

Legitimacy And Agency Implementation Of Title Ix, Samuel R. Bagenstos

Articles

Title IX of the Education Amendments of 1972 prohibits sex discrimination by programs receiving federal education funding. Primary responsibility for administering that statute lies in the Office for Civil Rights of the Department of Education (OCR). Because Title IX involves a subject that remains highly controversial in our polity (sex roles and interactions among the sexes more generally), and because it targets a highly sensitive area (education), OCR’s administration of the statute has long drawn criticism. The critics have not merely noted disagreements with the legal and policy decisions of the agency, however. Rather, they have attacked the agency’s decisions …