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All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

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An Economic Analysis Of Farm Flock Sheep Production In Utah, Ken Beck May 1981

An Economic Analysis Of Farm Flock Sheep Production In Utah, Ken Beck

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to evaluate the economic aspects of farm flock sheep production in Utah. Using 1979 as a base year, costs and returns were calculated from data obtained from twenty- six Utah farms. Characteristics that typify the states· farm flock sheep production, at this writing, with regard to: 1) the farm flock producers and 2) the farm flock enterprise, were presented.

Various models were dev eloped and examined using Multiple Regression and Linear Programming analytical techniques. Multiple Regression was us ed to estimate the effects that different variables had on the profitability of the sheep enterprise. …


Effect Of Rain Leaching On Chemical Composition Of Alfalfa Hay, Mercedes M. Garcia De Hernandez May 1981

Effect Of Rain Leaching On Chemical Composition Of Alfalfa Hay, Mercedes M. Garcia De Hernandez

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Yield and chemical changes of second-cutting alfalfa hay treated with artificial rain were determined in a 2 x 3 x 2 factorial experiment. Factors were 2 stages of maturity (1 = late vegetative; 2 = early bloom), 3 levels of artificial rain applied (1 = no rain; 2 =low or approximately 5 mm; 3 = high or approximately 20 mm), and 2 times of applying artificial rain (1 = when drying forage was 40-60% dry matter; 2 = when drying forage was 60-75% dry matter). Thirty samples of alfalfa were collected at the 2 stages of maturity when the alfalfa …


Alterations In Rat Brain Norepinephrine And Dopamine Levels And Synthesis Rates In Response To Five Neurotoxic Chemicals: Acrylamide, 2,5-Hexanedione, Tri-O-Tolyl Phosphate, Leptophos, And Methyl Mercuric Chloride, Charles N. Aldous May 1981

Alterations In Rat Brain Norepinephrine And Dopamine Levels And Synthesis Rates In Response To Five Neurotoxic Chemicals: Acrylamide, 2,5-Hexanedione, Tri-O-Tolyl Phosphate, Leptophos, And Methyl Mercuric Chloride, Charles N. Aldous

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Acrylamide, 2,5-hexanedione, Tri-o-tolyl phosphate and leptophos belong to three fundamentally different chemical classes but all four chemicals cause central-peripheral distal axonopathy. Some of these compounds have been shown to alter brain steady state levels of neurotransmitters or to inhibit the activities of adenosine triphosphatases which are involved in the uptake and storage of biogenic amines. Tests were performed to determine alterations in steady state levels of rat brain norepinephrine and dopamine in response to doses of the above chemicals and of the central nervous system toxin, methyl mercuric chloride sufficient to cause ataxia. Catecholamine synthesis rate constant estimations were performed. …


Effect Of Toxaphene On Collagen Synthesis In Fish Tissue: Organ Culture Studies And Prolyl Hydroxylase Activity Assay, Charles Franklin Luke May 1981

Effect Of Toxaphene On Collagen Synthesis In Fish Tissue: Organ Culture Studies And Prolyl Hydroxylase Activity Assay, Charles Franklin Luke

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Toxaphene is reported to cause defects in the collagen of fish. Chronic exposure to toxhaphene weakens the backbone of fish by decreasing the amount of collagen and usually increasing the amount of calcium in the bone which results in a more brittle and fragile bone.

We investigated the possible direct action of toxaphene on collagen synthesis by exposing vertebral and swim bladder organ cultures obtained from unexposed rainbow trout (Salmo gairdneri) fingerlings to the same lot of toxaphene found to cause this defect in vivio. Collagen produced by these organ cultures was measured by: (1) total 3 …


The Economic Impact Of Potential Changes In Federal Grazing Policies On Ranchers In Wayne County, Utah, Kib Elden Jacobson May 1981

The Economic Impact Of Potential Changes In Federal Grazing Policies On Ranchers In Wayne County, Utah, Kib Elden Jacobson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to select an area in Utah that was predominantly livestock oriented which used federal lands for livestock grazing, and to develop model ranches exemplifying the typical live-stock operation in the area. These model ranches were then used in a Budget Generator Program (BG) and a Linear Programming framework (LP) to simulate reductions of 25%, 50%, 75% and 100% reductions of BLM land usage. The results were then used to determine income changes, herd size changes, and resource usage in the models as the reductions took place.

The area chosen was Wayne County, Utah because …


An Economic Analysis Of The Akkar Plain Project, E. Douglas Chard May 1981

An Economic Analysis Of The Akkar Plain Project, E. Douglas Chard

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this paper is to determine the economic feasibility of the Akkar Plain Agricultural Development Project. Data were collected at representative villages throughout the Akkar Plain in Syria. The data were used to establish the economic setting at the present time on the Akkar Plain and to establish a basis for determining the economic justification for the future planned developments. Methodology used was a farm budget analysis of a before development and after development situation. Internal rate of return and benefit/cost ratio were the measures used to determine economic feasibility. The paper discusses previous work completed, the development …


Influence Of Lipophilicity On The Accumulation And Distribution Of Halogenated Phenols And A Pyridinol As Metabolites Of Pesticides In The Rat, Assed A. Attumi May 1981

Influence Of Lipophilicity On The Accumulation And Distribution Of Halogenated Phenols And A Pyridinol As Metabolites Of Pesticides In The Rat, Assed A. Attumi

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Exposure to halogenated phenols and pyridinols is of increasing concern because of their wide use and distribution. This research was initiated to determine the distribution, accumulation, and depletion of a group of halogenated phenols and a pyridinol in selected tissues of male weanling rats at different time intervals following a single oral dose of 0.33 or 1.66 m moles per kg body weight. The halogenated phenols and pyridinol were distributed differently in every tissue sampled following their administration, even though the amount administered was the same in each case. The concentrations in tissue were found in the order: 2,4,5-trichlorophenol > 4-bromo-2,5-dichlorophenol …


Biphenyl Hydroxylation By Vole Hepatic Microsomes, Moheb H. Makary May 1981

Biphenyl Hydroxylation By Vole Hepatic Microsomes, Moheb H. Makary

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Metabolism of biphenyl by meadow voles (Microtus montanus) liver microsomes was studied by gas liquid chromatography. The microsomal biphenyl hydroxylation of Swiss Webster mice (outbred) was also investigated to provide a species comparison. 4-hydroxybiphenyl (major metabolite), 3-hydroxy biphenyl (minor) and smaller amounts of 2-hydroxybiphenyl were identified as metabolites of biphenyl incubated with vole liver microsomes. Liver microsomes from Swiss mice formed 4-hydroxy biphenyl (major metabolite) and almost equal amounts of 2- and 3-hydroxy biphenyl (minor metabolite). The amount of the hydroxy biphenyls formed by vole liver microsomes was considerably less per milligram of microsomal protein than for mice. …


An Economic Analysis Of Prairie Dog Control, Alan Robert Collins May 1981

An Economic Analysis Of Prairie Dog Control, Alan Robert Collins

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Prairie dog control was found to be economically feasible on the Conata basin in South Dakota with future annual maintenance control to prevent re-invasions. The large difference between the present net worth values of the two viewpoints ($2587 for the U.S. Forest Service acting as an agent of the sovereign and $109,011 for the ranchers) was due to the added costs of environmental considerations included in the U.S. Forest Service control program, but assumed not to be included in control by ranchers. In order for prairie dog control to remain economically feasible, annual maintenance control for the U.S. Forest Service …


The Transport And Intracellular Distribution Of Iron In The Basidiomycete, Ustilago Sphaerogena, Charles W. Passavant May 1981

The Transport And Intracellular Distribution Of Iron In The Basidiomycete, Ustilago Sphaerogena, Charles W. Passavant

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The transport and intracellular distribution of iron in Ustilago sphaerogena via the native siderochrome ferrichrome A has been examined. Evidence is presented which suggests the involvement of deferriferrichrome in iron transport when the metal is supplied to the cell as ferrichrome A. This process requires both oxygen and ATP synthesis and may require a transmembrane electrochemical gradient. Once inside the cell, iron derived from ferrichrome A is rapidly distributed, with a major fraction found in the mitochondria, presumably as heme.

The kinetics of ferrichrome and ferrichrome A uptake have also been investigated. The Km of transport of ferrichrome was …


Common Use Grazing Studies On Southern Utah Summer Range, Al F. Schlundt May 1980

Common Use Grazing Studies On Southern Utah Summer Range, Al F. Schlundt

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Two common use grazing trials were conducted during two summer grazing seasons (1978-1979) on a typical shrubby grassland site on the Kolab Terrace, about 20 miles (32 km) southeast of Cedar City, Utah, at an elevation of about 8500 feet (2600 m). Two animal units of ewes with lambs, or cows with calves, or both were stocked in each of six, one-acre (0.39 ha) pastures. A five to one substitution ratio provided two single-species and one mixed (five ewes with lambs and one cow with calf) livestock treatments replicated twice. The pastures were grazed for nine days during which time …


Effects Of Ddt Upon The Hematology And Immunology Of The Goldfish (Carassius Auratus), Maurice G. Zeeman May 1980

Effects Of Ddt Upon The Hematology And Immunology Of The Goldfish (Carassius Auratus), Maurice G. Zeeman

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

DDT can cause hematological and immunological alterations in mammals and birds. Interference with normal hematological and immunological defense systems has been strongly linked to increased incidences of disease and tumors. Fish exposed to pesticides have been noted to be more susceptible to disease. This study examined DDT effects on goldfish hematological and immunological parameters.

Adult goldfish were kept in 250 liter aquaria at 25 ± 1° C. Fish were dosed intraperitoneally with p,p'-DDT in corn oil. Doses ranged from 0 to 500 mg/kg for acute (96 hour) hematology studies to 0 to 50 mg/kg for sub-acute hematology and immunology studies. …


Taxpayer Satisfaction With Public Urban Services In Salt Lake County, Lea J. Cottam May 1980

Taxpayer Satisfaction With Public Urban Services In Salt Lake County, Lea J. Cottam

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Although citizens do not generally consider themselves consumers of public services in the same Sense they consider themselves consumers in the retail marketplace, their demand for public services clearly affects what local government units provide. Citizens are involved daily with the consumption of public urban services; yet most consumer education textbooks and teaching materials ignore tax supported services.

The purpose of this study was to measure the satisfaction of consumers with certain public urban services, public officials, and several units of government.

Satisfaction was found to be correlated with age, length of residence in the community and the respondents' attitudes …


Proxemic Behaviors Of Sociometrically Identified Preschool Children, Laura Gaynard May 1980

Proxemic Behaviors Of Sociometrically Identified Preschool Children, Laura Gaynard

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

From a population of 160 children, 59 were sociometrically identified into four categories: popular, amiable, isolated, and rejected. Same-sexed pairs of children were then observed in an experimental play situation in which two experimenters, using a computerized event recorder, obtained the amount of time each identified child spent at various distances (0-305 cm) from the confederate. Frequency of moves was also recorded. A general pattern of proxemic behavior for all children, across category, was found to exist in which subjects spent the majority of time at distances of 30.5 cm to 122 cm and very little time at greater distances. …


Evaluation Of Six Strains Of Rainbow Trout (Salmo Gairdneri) Stocked As Fingerlings In Porcupine Reservoir, Utah, Mark Hudy May 1980

Evaluation Of Six Strains Of Rainbow Trout (Salmo Gairdneri) Stocked As Fingerlings In Porcupine Reservoir, Utah, Mark Hudy

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Different strains of rainbow trout (Salmo gairdneri), Ten Sleep, Sand Creek, Beitey, Shepherd-of-the-Hills, New Zealand, Fish Lake-Desmet, Desmet, were compared for survival to the creel, growth and catchability after being stocked in a fluctuating 80 ha Utah reservoir. Fish were stocked in the spring and fall as fingerlings and monitored by creel censusing, gill netting and electrofishing. Fish were tagged with coded wire snout tags prior to stocking. An angler opinion survey was conducted to determine angler satisfaction with numbers and size of fish caught.

Regardless of strain, spring stocking was superior to fall stocking in survival to …


Accumulation Of Formaldehyde And Its Relation To Postmortem Aging Of Non-Gadoid Fish Species, Mohamad A. Al-Kanhal May 1980

Accumulation Of Formaldehyde And Its Relation To Postmortem Aging Of Non-Gadoid Fish Species, Mohamad A. Al-Kanhal

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Three non-gadoid fish species, trout (Cynoscion regalis), English sole (Paraophyrys vetulus) and Pacific red snapper (Scomber japonicus) have been tested for the recovery of trimethylamine oxide (TMAO), trimethylamine (TMA), dimethylamine (DMA), and formaldehyde (FA) during postmortem storage at 4°C and -5°C. TMAO, TMA, and DMA content was determined by measuring them as the salt derivative of picric acid. FA was determined by using the 3-Methyl-2-Benzothiazolinone hydrazone test.

In muscle tissue of red snapper and English sole, it was clear that initially TMAO decreased during storage at 4°C, while the amounts of TMA, DMA, and …


Variations In Volatiles From Lamb Adipose Tissue, Yn-Mei Chen May 1980

Variations In Volatiles From Lamb Adipose Tissue, Yn-Mei Chen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Lamb adipose tissue, representing 4 breeds, 3 sex-types and 3 weight categories, were studied to measure the variation in the flavor profile between individual animals, based on breed, sex- type and carcass weight. The flavor concentrates were prepared by steam distillation, ether extraction and fractionation. Pooled samples were prepared in the same way to measure any variations due to methodology.

Gas chromatographic separation and statistical analysis, based on analysis of variance, indicated that 21 peaks out of 124 peaks showed significant differences (at 5% level or 1% level). Among these 21 peaks, 5 were affected by breed, 4 by sex-type, …


The Effects Of Dietary Calcium And/Or Iron Deficiency Upon Murine Intestinal Calcium Binding Protein Activity And Calcium Absorption, Catherine M. Mcdonald May 1980

The Effects Of Dietary Calcium And/Or Iron Deficiency Upon Murine Intestinal Calcium Binding Protein Activity And Calcium Absorption, Catherine M. Mcdonald

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Iron deficiency has been shown to impair calcium absorption, leading to decreased bone mass. Vitamin D3-dependent calcium binding protein (CaBP) has been demonstrated to be necessary for the active transport of calcium in the intestine of numerous species. Iron deficiency might affect the activity of the calcium binding protein.

Four experimental diets were formulated as follows: Diet 1, iron adequate, calcium adequate; Diet 2, iron deficient, calcium adequate; Diet 3, iron adequate, calcium deficient; Diet 4, iron deficient, calcium deficient. Weanling, female rats were separated into 4 groups of 48 animals each and fed the respective diet for a period …


Optimum Enzyme Treatment For Liberation And Assay Of Pantothenic Acid In Blood, Jan Pearson May 1980

Optimum Enzyme Treatment For Liberation And Assay Of Pantothenic Acid In Blood, Jan Pearson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A great deal of variability has been evident in reported pantothenic acid blood values. The purpose of the study was to establish optimum enzyme treatment for liberation and assay of pantothenic acid in blood and sera.

There were eight major findings. First, it was found that there was an active pantetheinase in sera, negating the need for hog kidney peptidase or pigeon liver enzyme in whole blood. The second finding (related to the first) indicated that there was significant autolysis of the peptidase bond between the pantothenic acid and cysteamine moieties of coenzyme A in whole blood. The third finding …


The Effects Of A Calcium Pectinate Film Upon Shrinkage, Palatability And Surface Microbial Growth On Carcasses And Selected Beef And Poultry Cuts, Clifford Arthur Stubbs May 1980

The Effects Of A Calcium Pectinate Film Upon Shrinkage, Palatability And Surface Microbial Growth On Carcasses And Selected Beef And Poultry Cuts, Clifford Arthur Stubbs

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A process in which low methoxyl pectin is applied to the surface of meat carcasses and poultry to reduce shrinkage, maintain color and improve shelf life was evaluated. A 3.0 percent aqueous low methoxyl pectin (acidified with 1.4 percent acetic acid if required) was applied to beef, lamb and turkey carcasses by spraying and caused to form a gel coating by overspraying with a 3.5 percent calcium chloride salt solution.

Turkey carcasses treated with acidified pectin or acidified pectin after 3.0 percent acetic acid dip for 30 seconds were not significantly improved in shelf life over carcasses which were acid …


Pantothenic Acid Status In An Elderly Population, Nedra K. Christensen May 1980

Pantothenic Acid Status In An Elderly Population, Nedra K. Christensen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

There has been insufficient data available for suggesting a recommended dietary allowance for pantothenic acid in the elderly population. The purpose of this study was to determine the average dietary intake of pantothenic acid and correlate it with urinary excretions and the blood levels of this vitamin to assess the pantothenic acid status of the elderly population.

A seven day diet record was obtained from 65 non-institutionalized and 26 institutionalized persons over 65 years of age assessed to be free of chronic diseases. A 24 hour urine specimen and a fasting blood sample was obtained from each study participant. An …


Production Of Mountain Whitefish (Prosopium Williamsoni) In Altered And Unaltered Reaches Of Two Intermountain Streams In Their Alluvial Flood Plains, Michael J. Ottenbacher May 1980

Production Of Mountain Whitefish (Prosopium Williamsoni) In Altered And Unaltered Reaches Of Two Intermountain Streams In Their Alluvial Flood Plains, Michael J. Ottenbacher

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Estimates of production and related parameters (growth rate, density, standing crop) were made for populations of mountain whitefish in altered and "unaltered" areas of the Blacksmith Fork and Logan River, Utah from spring 1975 through summer 1976. Capture records of marked whitefish were also analyzed to describe fish movement and check on assumptions implicit in the population estimator.

Mean weights and instantaneous growth rates of whitefish were similar at all sites for comparable size/age groups. Among sites, differences in production per sampling interval and annual production were due mainly to differences in standing crop and/or age structure.

Estimates of mountain …


Resource Partitioning In Breeding Populations Of Marsh Hawks And Short-Eared Owls, Susan C. Linner May 1980

Resource Partitioning In Breeding Populations Of Marsh Hawks And Short-Eared Owls, Susan C. Linner

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

During the 1979 breeding season four pairs of northern harriers, or marsh hawks (Circus cyaneus) and four pairs of short-eared owls (Asio flammeus) were studied in Cache Valley, Utah. The study was concerned solely with diurnal resource utilization, and did not examine the owls' nocturnal activities. The home range of each harrier pair overlapped substantially with that of an owl pair. Percent habitat overlap for hawk-owl pairs varied from 39 percent to 72 percent. Observations were made to determine if differences existed in their utilization of habitat and food resources, or in their daily and seasonal …


Effects Of Host Plant Patch Size And Surrounding Plant Type On Insect Population Dynamics, Lynn A. Maguire May 1980

Effects Of Host Plant Patch Size And Surrounding Plant Type On Insect Population Dynamics, Lynn A. Maguire

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of the present study was to investigate how plant spatial patterns and insect behavior interact to influence the population dynamics of insects using the plants. The study included three phases: l) field experiments using collards (Brassica oleracea) and the crucifer insect fauna; 2) simulation models representing the population dynamics of an insect herbivore as functions of insect dispersal behavior and host plant patch size; and 3) model-field syntheses integrating model predictions and field variability estimates to choose an appropriate spatial scale for future field experiments or applications.

In field experiments on surrounding plant type, collards were …


Effects Of Reinforcement On The Iq Scores Of Preschool Children As A Function Of Initial Iq, Richard H. Weiss May 1980

Effects Of Reinforcement On The Iq Scores Of Preschool Children As A Function Of Initial Iq, Richard H. Weiss

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The effects of tokens as reinforcers on IQ test performance was investigated in 45 preschool Head Start children. There were 63 children assessed using the Slosson Intelligence Test for Children (SIT), and based upon these scores, were divided into three IQ groups: low, average and high. There were 15 children randomly selected from each group and within each of these groups, subjects were randomly assigned to one of three conditions: Control (C) , Pretest experimental (E1), and no pretest experimental (E2). The C and E1 groups were administered the Peabody Picture Vocabulary Test (PPVT), Form …


Primary Representational Systems As A Basis For Improved Comprehension And Communication, Alan Thomas "Chip" Mattar May 1980

Primary Representational Systems As A Basis For Improved Comprehension And Communication, Alan Thomas "Chip" Mattar

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this dissertation was to determine the usefulness of primary representational systems (prs) as a basis for improved comprehension and communication. Primary representational systems were discussed as being cognitive representations of experience which are revealed through auditory (A), visual (V), or kinesthetic (K) language.

Specifically, this study tested Bandler and Grinder's assumption that an identified A, V, or K individual would better comprehend a communication which contained predicates representative of that individual's prs. Comprehension was operationalized into general information (GI) and specific predicate usage (SPU) segments in order to isolate possible group differences on this dimension.

A total …


Hurricane Designed, Karen E. Lee May 1980

Hurricane Designed, Karen E. Lee

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Hurricane Designed is a project that deals with advertising graphics, their forms and adaptations, and relates them to their environment. Herein is an explanation of the development and procedures of this project as it grew out of an interest in natural history and a pursuit of elegance in design. The result is this plan for a community identity based on environmental and historical perspective.


The Imitation Of Prosocial Behaviors In Children: The Effects Of Peer And Adult Models And Vicarious Reinforcement, Richard Louis Sanok May 1980

The Imitation Of Prosocial Behaviors In Children: The Effects Of Peer And Adult Models And Vicarious Reinforcement, Richard Louis Sanok

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of the present laboratory study was to investigate the relative effects of sharing and nonsharing peer and adult models on the facilitation of prosocial behaviors with and without reinforcement to the model. One hundred and sixty second and third grade children served as subjects and were randomly assigned to six treatment groups and one control group. For replication purposes, half of the subjects participated in each condition prior to the second half doing so.

Children in the treatment groups viewed videotaped sequences portraying both a male and female model sharing or not sharing tokens with poor children. Models …


An Analysis Of A Measure Of Productivity In Mule Deer Populations, Ronald J. Ryel May 1980

An Analysis Of A Measure Of Productivity In Mule Deer Populations, Ronald J. Ryel

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to investigate the relationship between the fall proportion of fawns among fawns and does in a mule deer population and two measures of productivity, the spring recruitment rate and the reproductive performance as measured in the fall. The spring recruitment rate was defined to be the number of fawns per doe which were recruited into the population at 1 year of age. The reproductive performance was defined to be the number of fawns produced per doe 2 years or older which survive to a specified time. The relationships between these quantities were measured by …


Inhibition Of Synaptosomal Biogenic Amine Transport By A Diverse Group Of Neurotoxic Chemicals, William M. Bracken May 1980

Inhibition Of Synaptosomal Biogenic Amine Transport By A Diverse Group Of Neurotoxic Chemicals, William M. Bracken

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Synaptosomal membrane functions were monitored, after in vitro exposure to select environmental pollutants, in synaptosomal preparations originating from rat cerebral cortices. The uptake of NE and 5HT into the synaptosomes was monitored as was the K+-dependent phosphate activity of the membrane. CH3HgCl, Hg(NO3)2, CdCl2, diisopropylfluorophosphate (DFP), paraoxon, acrylamide and Kepone were the test chemicals whose effects were studied.

CH3HgCl, Hg(NO3)2 and Kepone had the greatest inhibitory effects on NE and 5HT uptake. The concentrations producing 50 percent inhibition (IC50) were 1.4 x 10 …