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The Power Of Connection: Unraveling The Significance Of Social Support In The Stress Levels Of Informal Black Women Caregivers, Antoinette Shantay Williams
The Power Of Connection: Unraveling The Significance Of Social Support In The Stress Levels Of Informal Black Women Caregivers, Antoinette Shantay Williams
All ETDs from UAB
This study examines how three types of social support—having someone to talk to, someone to help with activities, and someone to provide care—affect the stress levels of informal Black women caregivers compared to Black men, White men, and White women caregivers in the United States. It explores the intersection of race and gender, with a specific focus on how social support influences the emotional, financial, and physical stress levels of informal Black women caregivers. This research aimed to answer two questions. Does social support decrease stress levels among informal caregivers? Does the association between social support and stress levels differ …
"The Association Between Serious Psychological Distress And Life Satisfaction Among U.S Adults With Hypertension", Kellen Michael Lenz
"The Association Between Serious Psychological Distress And Life Satisfaction Among U.S Adults With Hypertension", Kellen Michael Lenz
All ETDs from UAB
Purpose: Given the observed link between psychosocial and physical health outcomes, this study investigates the association between serious psychological distress and life satisfaction among U.S adults with hypertension. Methods: A cross-sectional study using 2021 National Health Interview Survey data among U.S adults was conducted to investigate the association between serious psychological distress and hypertension and assess the role of life satisfaction in modifying this relationship. Hypertension (diagnosed, undiagnosed), serious psychological distress (≥ 13 on the Kessler 6 nonspecific distress scale), and life satisfaction (Very satisfied, Satisfied, Dissatisfied, Very dissatisfied) were self-reported by participants. Ordinal logistic regression was used to investigate …
Exploring The Associations Between Cognitive Training, Social Determinants Of Health, And Driving Behaviors: A Longitudinal Analysis Of The Active Study, Katie Wheeler
All ETDs from UAB
As the average lifespan increases, older adults are remaining independent into older ages than before. The ability to drive a vehicle is an essential part of daily living that helps older adults maintain independence. Cognitive training, specifically speed of processing training (SOPT), is an intervention that has consistently shown to benefit older adult’s driving abilities and driving behaviors. This dissertation examined the longitudinal association between cognitive training and primary driving location on crash risk across 20 years (Paper 1), investigated the effects of cognitive training and dosage on driving mobility across 10 years (Paper 2), and explored social determinants of …
Predicting Maximum Concentric And Eccentric Squat Strength From Maximum Isometric Squat Strength, Michael A. Dunn
Predicting Maximum Concentric And Eccentric Squat Strength From Maximum Isometric Squat Strength, Michael A. Dunn
All ETDs from UAB
Resistive squat exercise is a well-established technique to enhance the strength of muscles and bone of the back in humans. Such type of exercise could prove highly beneficial for individuals with pathological condition of the back such as osteoporosis. Notably, the rehabilitation programs aimed at strengthening the muscles and bone of the back require the knowledge of the patient’s one repetition maximum (1RM). Finding the 1RM squat value could lead to injury due to the higher weights involved. In addition, testing for 1RM could be not feasible in older populations or young population with chronic back conditions The isometric squat …
The Association Between Cardiovascular Disease Risk And Fractures In Postmenopausal Women, Rafeka Hossain
The Association Between Cardiovascular Disease Risk And Fractures In Postmenopausal Women, Rafeka Hossain
All ETDs from UAB
Background: Fragility fractures pose a significant healthcare and economic burden in the United States. While age and bone mineral density (BMD) are the primary established risk factors for fragility fractures, the relationship between cardiovascular disease (CVD) and fractures remains underexplored. The primary objective of this analysis was to estimate the association of CVD risk with fractures in postmenopausal women. Methods: Utilizing 30 years of data from the WHI, Atherosclerotic Cardiovascular Disease (ASCVD) risk scores were computed using baseline age, race, systolic blood pressure, total cholesterol, high-density lipoprotein, diabetes, anti-hypertension medications, and smoking. Fracture outcomes encompassed any clinical fracture, major osteoporotic …
Increasing Patient Safety By Reducing Falls Among In-Hospital Community-Dwelling Patients 65 Years Old Or Older By Using A Shift Change Fall Safety Checklist, Janice Isaac Brooks
Increasing Patient Safety By Reducing Falls Among In-Hospital Community-Dwelling Patients 65 Years Old Or Older By Using A Shift Change Fall Safety Checklist, Janice Isaac Brooks
All ETDs from UAB
This manuscript is designed to promote and improve healthcare safety, quality, efficiency, and lower medical costs for hospitals and patients. Falls, fall injuries, and their devastating consequences are rising, yet falls are preventable even among senior patients. Search Engines and Key Terms SciWheel was used to save the literature and eliminate duplications. Key terms were used in the Boolean strings: elderly fall prevention, senior fall safety, in-hospital fall prevention, falls in the aging, and fall prevention tools. The CINAHL Plus yielded 58. PubMed search yielded 121. And Google Scholar yielded 32. The total of all three searches was 211. Thirteen …
The Association Of Cognitive And Physical Functioning With Health And Mortality Outcomes Among Puerto Ricans, Cheyanne Celine Barba
The Association Of Cognitive And Physical Functioning With Health And Mortality Outcomes Among Puerto Ricans, Cheyanne Celine Barba
All ETDs from UAB
Puerto Rico has experienced a rapid increase in the older adult population over the last decade. With a growing older adult population, the importance of healthy aging becomes increasingly more important to understand. Understanding the impact that impairments in cognitive and physical functioning have on older adults in Puerto Rico will be important to supporting the rapidly aging population. The current project proposed to (1) examine predictors of transition to frailty, (2) examine whether cognitive function and frailty are associated with healthcare utilization, and (3) examine frailty and cognitive impairment as predictors of mortality and Alzheimer’s disease related cause of …
The Impact Of Diabetes On At-Fault Motor Vehicle Collisions In Older Adults: Visual Function, Medication, And Crash Characteristics, Thomas A. Swain
The Impact Of Diabetes On At-Fault Motor Vehicle Collisions In Older Adults: Visual Function, Medication, And Crash Characteristics, Thomas A. Swain
All ETDs from UAB
Older drivers represent one of the fastest growing age groups of drivers in the United States. Crash risk among older adults, who have the highest prevalence of vision impairment, has been shown to be related to worse visual function. Diabetes mellitus is a chronic health condition affecting more than 23.1 million Americans, and one in three have pre-diabetes. Persons with diabetes are at increased risk of conditions which cause vision loss. Research indicates those with diabetes have higher rates of MVCs. Despite the increased MVC risk among each of these groups, work has yet to evaluate if diabetes modifies the …
Aging With Hiv And Comorbid Chronic Obstructive Pulmonary Disease, Jun Yeong Byun
Aging With Hiv And Comorbid Chronic Obstructive Pulmonary Disease, Jun Yeong Byun
All ETDs from UAB
Older adults with human immunodeficiency virus (HIV) experience a high prevalence of chronic obstructive pulmonary disease (COPD). Considering having either HIV or COPD is related to worse health outcomes in older adults, aging with both HIV and COPD may synergistically and negatively affect the health outcomes of older people with HIV (PWH) and comorbid COPD. The purpose of this dissertation was to explore the aging of PWH with COPD. This purpose was accomplished through three articles: 1) an adaptation of a gerontological model investigating what is known about the aging of PWH and people with COPD and extrapolating that to …
Pharmacologic Proteasome Activators Ameliorate Alzheimer's-Like Pathology In Ad Fly Models, Mehar Bano
Pharmacologic Proteasome Activators Ameliorate Alzheimer's-Like Pathology In Ad Fly Models, Mehar Bano
All ETDs from UAB
The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays a critical role in nervous system processes. This includes the maintenance of cellular homeostasis in neurons (1). It also includes synaptic efficacy and plasticity as well as protein turnover, presynaptic vesicle transport, and neuronal protesostasis. Proteasome function is impaired as a consequence of aging, which is aggravated by conditions like Alzheimer's Disease and Related-Dementias (AD, ADRD) (2). According to earlier work from our lab the proteasome is critical to how quickly AD progresses. In Drosophila, human cells, and …
Role Of Dpy30 In The Epigenetic Regulation Of Odontoblast Differentiation In Vitro, Namrata Landge Rana
Role Of Dpy30 In The Epigenetic Regulation Of Odontoblast Differentiation In Vitro, Namrata Landge Rana
All ETDs from UAB
Purpose: Dentin is produced from odontoblasts, derived from human Dental Pulp Cells (hDPCs), which are essential for dentin formation, remodeling, and mineral hemostasis. Epigenetic mechanisms are believed to be involved in odontoblast differentiation and function, and H3K4 methylation is associated with gene activation which is fundamental to histone-based epigenetics. The SET1/MLL complexes are mammals' major histone H3K4 methylation enzymes. DPY30 is a core subunit of SET1/MII complexes, mammalian's major histone H3K4 methyltransferases. It plays an important role in regulating fundamental processes including the determination of cell lineage, growth, and differentiation. Thus, histone-based epigenetic mechanisms are involved in odontoblast differentiation and …
Successful Aging Among Midlife Black Women: A Latent Class Analysis, Joshua Christian Julian Lewis
Successful Aging Among Midlife Black Women: A Latent Class Analysis, Joshua Christian Julian Lewis
All ETDs from UAB
Successful aging (SA), as outlined by Rowe and Khan, with its objective focus on disease and disability avoidance, maintaining high physical and cognitive function, and sustaining engagement in social and productive activities, was meant to be a benchmark for assessing health and aging. However, given its rigid criteria virtually no one “ages successfully” despite being in otherwise relatively good health. The assumption of unsuccessful aging in populations who experience a higher prevalence of chronic disease, illness, disability, and other health disparities, is implicit in the SA framework outlined by Rowe and Khan and would preclude many Black women from being …
Examining Sex And Race Difference In Obesity Risk Factors In Older Americans Using Genetic And Lifestyle Data In Regards, Hairui Yu
All ETDs from UAB
Obesity is a prevalent chronic condition determined by social, psychological, behavioral, and biological factors. The prevalence of obesity remains a major public health issue and has continued to rise in the United States and around the world. People who are obese face a higher risk of cardiovascular and metabolic diseases. The fat mass and obesityassociated gene (FTO) is one of the most commonly identified genes in obesity-related research. This three-paper dissertation is aimed at improving understanding of sex and race differences in obesity risk factors in older Americans from genetic (FTO SNPs) and lifestyle (diet and physical activity) perspectives, using …
Labor Union Membership Tenure And Midlife Health: A Gendered Perspective, Clifford Ross
Labor Union Membership Tenure And Midlife Health: A Gendered Perspective, Clifford Ross
All ETDs from UAB
The benefits of labor unions have not gone unstudied. Individuals in labor unions have better access to lower cost/more substantial health insurance plans, higher quality pension plans, and better wages leading to increased lifetime earnings. Even though many of these benefits create important pathways that could lead to better health, unions have been paid little attention in health literature. Additionally, in the modern workplace Mothers are offered lower starting salaries, are perceived as less competent, and face a penalty regarding hiring, promotion, and workplace educational opportunities. Compared to men, women with children see an income gap 20 cents wider than …
Multilevel Influences On Physical Activity Participation In Rural And Cancer Populations With Obesity, Nashira Inika Brown
Multilevel Influences On Physical Activity Participation In Rural And Cancer Populations With Obesity, Nashira Inika Brown
All ETDs from UAB
espite the strong evidence of physical activity benefits, the prevalence of physical inactivity and associated obesity continues to increase. Rural and cancer survivor populations with obesity, in particular, remain highly inactive and are at increased risk of comorbidities. Thus, physical activity interventions are needed to promote active lifestyles. However, before developing or adapting existing multi-level physical activity interventions, more research is needed to understand the necessary components to meet the needs and preferences of these unique populations. Therefore, this project involved identifying the gaps in literature followed by three studies to investigate the multilevel influences on physical activity in rural …
The Roles Of Racial Discrimination And Sleep In Cognitive Functioning In Diverse Youth, Queenisha Crichlow
The Roles Of Racial Discrimination And Sleep In Cognitive Functioning In Diverse Youth, Queenisha Crichlow
All ETDs from UAB
Cognitive functioning is an important aspect of human development that is closely related to youth academic outcomes (Caemmerer et al., 2018). Specifically, there is evidence that cognitive abilities such as memory, attention, and self-control are predictive of academic achievement in youth (Peng & Kievit, 2020). Current research suggests that chronic stress reduces cognitive functioning (Korten et al., 2014), but few studies have examined this relationship for race-related stress, specifically racial discrimination. Considering that racial discrimination is a common and reoccurring type of stress in the lives of minority youth (Hughes et al., 2016), it is possible that chronic exposure to …
Smoking And Perceived Stress: Examining The Impact Of Racial Identity And Risk For Obstructive Sleep Apnea Through A Moderated Mediation Model, Sofia Mildrum Chana
Smoking And Perceived Stress: Examining The Impact Of Racial Identity And Risk For Obstructive Sleep Apnea Through A Moderated Mediation Model, Sofia Mildrum Chana
All ETDs from UAB
Background: Cigarette smoking is known to have a negative effect on individuals’ sleep quality, and symptoms of insomnia. Smoking can particularly exacerbate sleep disorders such as obstructive sleep apnea (OSA) by increasing irritation and inflammation of the upper respiratory conducts. Previous research highlights the complex positive association between cigarette smoking and perceived stress. Sleep may be an important aspect intervening in the association between smoking and perceived stress, given that individuals who report high stress also report worse sleep quality and are at greater risk for OSA. However, limited research has examined the indirect association of cigarette smoking and perceived …
Life-Space Mobility In The Older Adult, Community-Dwelling Cancer Survivor In The Deep South: A Secondary Data Analysis, Richard A. Taylor
Life-Space Mobility In The Older Adult, Community-Dwelling Cancer Survivor In The Deep South: A Secondary Data Analysis, Richard A. Taylor
All ETDs from UAB
By 2040, the U.S. is projected to have 26.1 million cancer survivors; 73% of these will be over 65 years old. Much is known about life-space mobility (LSM) in patients with non-cancer serious illnesses. Restricted LSM affects every aspect of an older adult’s life; their independence, autonomy, and quality of life (QOL). To date, there are no studies examining LSM in older cancer survivors. Therefore, we examined LSM, factors that affect LSM, and the relationship between LSM and QOL in older cancer survivors using existing data from the University of Alabama at Birmingham (UAB) Study of Aging (SOA) (NIA AG15062). …
The Relationship Between Nurse And Therapy Staffing Levels And The Medicare Patient-Driven Payment Model Reimbursement During The Covid-19 Pandemic, Roland T. Shapley
The Relationship Between Nurse And Therapy Staffing Levels And The Medicare Patient-Driven Payment Model Reimbursement During The Covid-19 Pandemic, Roland T. Shapley
All ETDs from UAB
The Patient Driven Payment Model (PDPM) brought about a paradigm shift in the way skilled nursing facilities are reimbursed, by linking complexity of care to beneficiary need, expanding case-mix adjusted components by including a non-therapy ancillary and speech language pathology component, and limiting the volume of therapy services provided. The COVID-19 pandemic wreaked havoc upon the nursing home industry that gave rise to high patient and staff infections and fatalities, declining occupancy rates, and nursing shortages, compelling the Department of Health and Human Services to provide $4.9 billion in CARES Funding to skilled nursing facilities (SNFs). Using Payroll Based Journal, …
Alzheimer Disease Special Care Units And Nursing Homes' Organizational Performance, Giovanna Pilonieta Ortiz
Alzheimer Disease Special Care Units And Nursing Homes' Organizational Performance, Giovanna Pilonieta Ortiz
All ETDs from UAB
Alzheimer’s disease special care units (AD SCUs) have been adopted to provide specialized care for people with dementia in nursing homes. However, the effects of environmental and organizational factors on AD SCUs adoption by nursing homes and their influence on nursing homes' organizational performance remains unclear. Guided by Resource Dependence Theory, Donabedian’s Structure-Process-Outcome (SPO) framework and the Resource-Based View of Firms perspective, the purpose of the three papers included in this dissertation was to provide empirical evidence of the contextual and organizational factors that influence AD SCUs adoption among nursing homes and how the adoption of AD SCUs impact nursing …
Palliative Care Experiences And Educational Needs Of Healthcare Interprofessionals In Jamaica: A Mixed Methods Study, Rebecca L. Edwards
Palliative Care Experiences And Educational Needs Of Healthcare Interprofessionals In Jamaica: A Mixed Methods Study, Rebecca L. Edwards
All ETDs from UAB
Universal access to palliative care (PC) is a human right that much of the world has not accomplished and educating a PC workforce is critical to PC advancement. Higher PC disparities exist in low-and-middle income countries, such as Jamaica. The World Health Organization Public Health Model and the International PC Initiative’s PC roadmap emphasize the importance of PC education. The purpose of this mixed methods dissertation study was to investigate the PC experiences and educational needs of healthcare interprofessionals who provide care for patients with late-stage serious illnesses in Jamaica. Three specific aims incorporated quantitative investigation of physicians’, nurses’, and …
The Association Between Post-Stroke Delirium And Mortality Among Stroke Patients In Long-Term Facilities, Nuo Xu
All ETDs from UAB
Delirium is a common neurobehavioral complication following a stroke. Patients who have post-stroke delirium (PSD) are more likely to have severe prognoses, such as physical function decline, high mortality and an increased need for long-term care. Nursing home residents as one of the fragile and special populations sharing the attributes of old age, and high prevalence of chronic diseases and limited mobility. However, there only a few studies have investigated the association between PSD and mortality among individuals admitted to a long-term care facility. This retrospective cohort study aimed to examine the association between PSD and mortality among the participants …
Effectiveness Of A University Employee Assistance Program Using The Workplace Outcome Suite And Client Satisfaction Survey, Josephine Jackson Banks
Effectiveness Of A University Employee Assistance Program Using The Workplace Outcome Suite And Client Satisfaction Survey, Josephine Jackson Banks
All ETDs from UAB
Background: Gallup (2013) reported that 30% of the U.S. workforce was not engaged in their work which means they were not reaching their full potential or productivity level. For organizations, lost productivity due to absenteeism or less than ideal performance at work impacts company performance and bottom line. Employee assistance programs are a resource to help increase employee health, productivity, and satisfaction through counseling interventions. Methods: Data were collected by a large urban university EAP over a 20-month period. The analysis was limited to EAP clients over the age of 18. A total of 866 subjects participated in this study, …
Predictors Of Subjective And Objective Everyday Functioning In Middle-Aged And Older Adults With Hiv, Alexandra Elaine Jacob
Predictors Of Subjective And Objective Everyday Functioning In Middle-Aged And Older Adults With Hiv, Alexandra Elaine Jacob
All ETDs from UAB
People with HIV (PWH) are at an increased risk for everyday functionalimpairment, especially as they age. The purpose of this study was: (1) to identify factors associated with subjective and objective instrumental activities of daily living (IADL) difficulty in PWH and (2) to identify factors associated with awareness of functional capacity. This cross-sectional study included 261 PWH. Participants completed a comprehensive neurobehavioral assessment, including self-report and performance-based measures of everyday functioning. Hierarchical multiple regressions were performed to identify health, psychological, and cognitive factors that contribute to subjective and objective evaluation of everyday functioning. We also examined factors that predicted a …
Characterization Of The Metabolic And Cognitive Features Of A Novel Alzheimer’S Disease Rat Model Along With Investigation Of Its Gut Microbiota Change Over Time, Akash Nagarajan
All ETDs from UAB
Alzheimer’s disease (AD) is currently the fifth highest cause of death in the United States and affects primarily individuals of very old age (>80 yrs.). Aging is known to be the biggest risk factor of AD. Recent studies have shown that AD patients have an altered gut microbiota composition. To investigate whether the Alzheimer’s disease pathology in the brain could drive gut microbiota changes during the adult and late life stage of the rat, we performed 16S ribosomal RNA sequencing on the fecal samples of the animals at 14 months and 20 months of age. We found a distinctive …
Self-Awareness Of Functional Deficits In Older Adults With Mild Cognitive Impairment, Kayla Ann Steward
Self-Awareness Of Functional Deficits In Older Adults With Mild Cognitive Impairment, Kayla Ann Steward
All ETDs from UAB
Performance of instrumental activities of daily living (IADLs) can become compromised in older adults with mild cognitive impairment (MCI). Poor self-awareness of deficits, also known as anosognosia, occurs in a substantial minority of those with MCI and varies in extent depending on the domain examined. This dissertation attempts to explain the inter- and intra-patient variability in anosognosia by examining (1) differences in objective IADL performance and self-awareness of functional difficulties between those with amnestic single- (-ASD) and multi-domain (-AMD) MCI, and by examining (2) the neuropsychological and (3) neuroanatomical correlates of anosognosia for IADLs in older adults across a broad …
Mitochondrial Priming Of Tumor Initiating Cells Involves Repression Of Mitochondrial Fission Activity Towards Redox Regulation Of The Cell Cycle Regulator Cyclin E, Brian Spurlock
All ETDs from UAB
Mitochondrial dynamics primarily refers to the opposing fission or fusion events between individual mitochondria, which maintains steady-state mitochondrial morphology in cells. Fission and fusion activities maintain the energetics of normal and neoplastic stem cells. We developed the novel approach mito-SinCe2 to study the bidirectional relationship between mitochondrial dynamics and energetics. Application of this method led to the hypothesis that mitochondria-dependent ovarian tumor initiating cells interconvert between 3 states with distinct mitochondrial energetics/dynamics relationships. Cells in one state, characterized by high mitochondrial ROS and low fission activity, appear to be primed for self-renewal by mitochondria. We call these cells mitochondria-primed stem …
Impact Of Registered Nurse Staffing Ratio On Nursing Home Operating Margins And Quality Measure Star Ratings, Douglas R. Whitman
Impact Of Registered Nurse Staffing Ratio On Nursing Home Operating Margins And Quality Measure Star Ratings, Douglas R. Whitman
All ETDs from UAB
Today’s nursing homes are under immense pressure from government regulators to improve quality while the government simultaneously tightens reimbursement rates. These two forces squeeze operating margins. The question facing nursing home operators is how to improve quality without breaking the bank. This study looks at the association of more registered nurses (RN) with quality and margins in U.S. nursing homes. This research project fills literature gaps which previously found improved nursing home quality correlates with more RNs. However, prior studies used self-reported data and typically considered only two or three quality measures. This study uses recently released electronic payroll data …
Life-Space And Cognitive Function By Cardiovascular Disease Risk: A Cross-Sectional Analysis From The Regards Study, Emiri Matsuda
Life-Space And Cognitive Function By Cardiovascular Disease Risk: A Cross-Sectional Analysis From The Regards Study, Emiri Matsuda
All ETDs from UAB
Performance on mobility assessments has been extensively linked to processing speed and executive function among older adults. However, less is known about the relationship between cognitive function and functional mobility as part of day to day life. African American individuals are at higher risk of cardiovascular complications, functional mobility, and cognitive decline compared to Whites. In addition, cardiovas-cular disease risk factors and neuropathology have been linked to impairment in several domains of cognitive function, including processing speed. The current study examined the cross-sectional association between life-space and cognitive function, specifically performance on the Digit Symbol Substitution Test (DSST), a measure …
Social Support And Self-Care Efficacy As Mediators Of Racial Disparities In Diabetes Health In Older Adults, Wesley Browning
Social Support And Self-Care Efficacy As Mediators Of Racial Disparities In Diabetes Health In Older Adults, Wesley Browning
All ETDs from UAB
Diabetes is a health problem that affects millions of Americans annually, and Black Americans have a higher prevalence with more complications than White Americans. A disparity exists between Black and White older adults living with diabetes in distress related to symptoms, treatment, and complications associated with the disease. Additionally, there are differences in levels of performing diabetes self-care behaviors between Blacks and Whites. One series of factors that may predict better diabetes self-care and diabetes distress in older adults are self-care efficacy and components of social support. This study used linear regression models to predict racial differences between Blacks and …