Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

All ETDs from UAB

Discipline
Keyword
Publication Year

Articles 481 - 510 of 2899

Full-Text Articles in Entire DC Network

O-Glcnac Regulation Of Inhibitory Circuits, Kavitha Abiraman Jan 2019

O-Glcnac Regulation Of Inhibitory Circuits, Kavitha Abiraman

All ETDs from UAB

Post translational modification of proteins plays a crucial role in regulating their function, and the role of one such modification, termed O-GlcNAcylation, is understudied. O-GlcNAcylation involves the dynamic cycle of adding and removing an O-linked N-acetylglucosamine (O-GlcNAc) by the enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which are highly expressed in the hippocampus. Enzymes that catalyze O-GlcNAcylation are found at both presynaptic and postsynaptic sites, and O-GlcNAcylated proteins localize to synaptosomes. We have shown that acute and selective increase in O-GlcNAcylation of AMPAR GluA2 subunits underlies expression of a novel form of LTD at CA3-CA1 synapses (O-GlcNAc LTD), as well …

Go to article

Metal Complexation In Hydrogen-Bonded Microcapsules Of Poly(N-Vinylpyrrolidone) And Tannic Acid For Medical Imaging And Controlled Drug Delivery, Patrick Aaron Alford Jan 2019

Metal Complexation In Hydrogen-Bonded Microcapsules Of Poly(N-Vinylpyrrolidone) And Tannic Acid For Medical Imaging And Controlled Drug Delivery, Patrick Aaron Alford

All ETDs from UAB

Even the most effective and widely used drugs in modern disease treatment can be compromised by low bioavailability and off-target damage which leads to detrimental side effects. Polymeric drug carriers have been developing in recent times with the aim of rendering the therapeutic cargo inert and protecting it from the body’s natural defense mechanisms until arrival at the target site, upon which a specific stimulus will cause the drug to release from the carrier locally. To this end, antioxidant capability in drug carriers can help mediate the cascade of reactive oxygen species that meet injected materials and, in doing so, …

Go to article

Mechanisms Of Acute Kidney Injury: The Role Of Ferritin Heavy Chain In Renal Heme-Unology, Laurence Marie Black Jan 2019

Mechanisms Of Acute Kidney Injury: The Role Of Ferritin Heavy Chain In Renal Heme-Unology, Laurence Marie Black

All ETDs from UAB

The kidneys are complex, multi-faceted organs that are responsible for regulatory processes, such as fluid homeostasis, hormone production, blood pressure regulation, and systemic toxin removal. Sudden disruption of these processes by acute kidney injury (AKI) causes rapid decline in renal function as well as significant morbidity and mortality. AKI is a significant clinical concern, affecting up to 13.3 million people globally each year and has the propensity to progress to chronic kidney disease (CKD), though the mechanism remains undefined. One reason for this is due to the lack of understanding of models used to study both AKI and CKD, hindering …

Go to article

St6gal-I Mediated Sialylation Promotes Pancreatic Ductal Adenocarcinoma Progression And Chemoresistance, Asmi Chakraborty Jan 2019

St6gal-I Mediated Sialylation Promotes Pancreatic Ductal Adenocarcinoma Progression And Chemoresistance, Asmi Chakraborty

All ETDs from UAB

ST6Gal-I adds α2-6 sialic acids to select N-glycosylated cell surface receptors, thereby modulating receptor function and intracellular signaling. ST6Gal-I is upregulated in various carcinomas and confers cancer stem cell (CSC) properties evidenced by tumorspheroid growth, chemoresistance and tumor initiating potential. In pancreatic ductal adenocarcinoma (PDAC), ST6Gal-I conferred gemcitabine resistance by abrogating DNA damage and altering expression levels of gemcitabine metabolism genes. Further, ST6Gal-I promoted resistance to chronic gemcitabine treatment. Additionally, metastatic clones of a PDAC cell line had increased ST6Gal-I expression and ST6Gal-I knockdown enhanced gemcitabine sensitivity. To investigate the physiological consequences of ST6Gal-I in PDAC, murine models were used. …

Go to article

Unintentional Childhood Injuries In Rural Uganda: The Role Of Sibling Supervision And The Potential For Behavior Change Through Classroom-Based Instruction, Marissa Swanson Jan 2019

Unintentional Childhood Injuries In Rural Uganda: The Role Of Sibling Supervision And The Potential For Behavior Change Through Classroom-Based Instruction, Marissa Swanson

All ETDs from UAB

Objective: Unintentional childhood injury is a significant global health burden particularly in low and middle income countries (LMIC). Effective supervision can reduce risk of injury to supervisees. Frequently, older siblings assist in supervising younger siblings, but may not be as effective as adult caregivers at preventing supervisee injury. The current investigation had three primary objectives: 1) Assess Ugandan adult caregivers’ self-reported expectations for children to provide sibling supervision; 2) Assess sixth-grade students’ self-reported experiences providing supervision; 3) Determine whether students’ supervision knowledge and skill improve through participation in the Super Siblings program, a novel classroom-based, culturally-adapted intervention. Methods: Adult caregivers …

Go to article

An Investigation Of Histocompatibility Testing And Mhc Class I In Xenotransplantation, Gregory Ryan Martens Jan 2019

An Investigation Of Histocompatibility Testing And Mhc Class I In Xenotransplantation, Gregory Ryan Martens

All ETDs from UAB

In the United States, hundreds of thousands of patients suffer from end-stage organ failure or terminal diseases without the option of a life-saving transplant because of severe organ shortages. Xenotransplantation offers a possible solution by using genetically engineered pigs as organ donors. Application of pig-to-human organ transplantation has been limited by antibody-mediated rejection (AMR), but recent genetic engineering advances have eliminated pig glycan xenoantigens and dramatically reduced antibody binding. In human-to-human transplantation, allotransplantation, AMR is prevented by pretransplant screening donors and recipients. The major histocompatibility complex (MHC), class I and II, are primary targets for antibodies and may also bind …

Go to article

Neurocognition In Patients With Primary Dystonia, Lindsay Niccolai Jan 2019

Neurocognition In Patients With Primary Dystonia, Lindsay Niccolai

All ETDs from UAB

Dystonia is defined as involuntary, sustained muscle contractions often causing twisting and repetitive movements. While dystonia is classified as a movement disorder with marked motor disturbance, there are also non-motor features associated with this disorder such as psychiatric, sensory, and neurocognitive deficits. This dissertation research focuses on the neurocognitive deficits found in patients with primary dystonia. Prior studies examining cognition in primary dystonia have often had the limitations of having small samples and lacking control groups. In addition, cognition is often assessed in deep brain stimulation (DBS) surgical candidacy evaluations, but neurocognitive deficits have not been studied as a predictor …

Go to article

Effects Of A Ketogenic Diet On Body Composition, Metabolic Health, And Quality Of Life In Ovarian And Endometrial Cancer Patients, Caroline Whitney Cohen Jan 2019

Effects Of A Ketogenic Diet On Body Composition, Metabolic Health, And Quality Of Life In Ovarian And Endometrial Cancer Patients, Caroline Whitney Cohen

All ETDs from UAB

Ketogenic diets (KDs) have garnered considerable research attention in recent years, having been investigated as a therapy for neurologic, metabolic, and even dermatologic diseases. Recent research has also focused on KDs as a potential intervention for cancer, with preclinical studies demonstrating profound effects such as inhibiting tumor growth, enhancing the effects of radiation and chemotherapy, and prolonging survival. However, to date few studies have been conducted in cancer patients. In order to determine if KDs might augment existing cancer treatment protocols, additional research is needed. Accordingly, the objective of this project was to conduct the first randomized, controlled trial examining …

Go to article

Examining The Role Of The Unfolded Protein Response In Depression, Matthew Timberlake Jan 2019

Examining The Role Of The Unfolded Protein Response In Depression, Matthew Timberlake

All ETDs from UAB

Depression is the leading cause of disability worldwide and impacts nearly 350 million people with a disproportionate representation in women with a 1:1.7 ratio of occurrence compared to men. This disorder is characterized by shifts in mood to include feelings of hopelessness, sadness, and lethargy as well as changes in diet, motivation, and sleep patterns. Further, over 50% of patients who struggle with depression also have suicidal ideation and as many as 10% of those commit suicide. At present, treatment plans include behavioral therapy (often) in conjunction with antidepressant medications which act on monoamines and their circuits in the central …

Go to article

Teachers’ Experiences Of Change From Traditional Teaching Methods To Active Participatory Learning Approaches Within The Alabama P-3 Pilot Program: A Case Study, Shushan Vardanyan Jan 2019

Teachers’ Experiences Of Change From Traditional Teaching Methods To Active Participatory Learning Approaches Within The Alabama P-3 Pilot Program: A Case Study, Shushan Vardanyan

All ETDs from UAB

This case study explored teachers’ experiences with the implementation of the Alabama P-3 initiative to move away from traditional teaching methods to active participatory learning (APL) approaches. Semi-structured interviews were conducted with nine teachers from four schools who taught kindergarten (K), first, or second grade. The data were analyzed through comparison of K and primary (P) teachers’ experiences of the implementation of the initiative using Lewin’s (1951) change theory as an a priori theory. The data were organized into two a priori themes: the process of change and forces influencing the change. The process of change theme was presented in …

Go to article

Effect Of Antidepressants On Cytokines Profiles Seen In Inflamed Tissue And Serum Samples In Patients With Moderate Chronic Periodontitis, Silvia M. Villalobos Jan 2019

Effect Of Antidepressants On Cytokines Profiles Seen In Inflamed Tissue And Serum Samples In Patients With Moderate Chronic Periodontitis, Silvia M. Villalobos

All ETDs from UAB

This study evaluated whether depression with or without the use of antidepressant was associated with changes in inflammatory markers, intraorally and systemically, GCF volume, serum biomarker levels. Cross-sectional data were collected from individuals with moderate periodontitis who were assigned to one of three groups based upon their medical history, medication usage, and answers to a validated survey instrument that assessed their level of clinical depression. Three groups of patients were compared: 1) patients with clinically diagnosed depression taking antidepressant medications [selective serotonin reuptake inhibitors (SSRIs), norepinephrine-dopamine reuptake inhibitor (NDRIs), or serotonin and norepinephrine reuptake inhibitors (SNRIs)]. 2) patients with clinically …

Go to article

Modulation Of Klotho Affects Dendritic Spine Remodeling And Neuronal Network Activity, Hai T. Vo Jan 2019

Modulation Of Klotho Affects Dendritic Spine Remodeling And Neuronal Network Activity, Hai T. Vo

All ETDs from UAB

Klotho protein expression has profound effects on lifespan where klotho-deficient mice exhibit premature aging phenotypes and live only to ~8 weeks of age while klotho-overexpressing mice have lifespans that are at least 20% longer than wild-type mice. Klotho expression also has similar effects on cognitive function as klotho-deficient mice develop cognitive impairment by 7 weeks of age and klotho-overexpressing mice show enhanced cognitive function. These effects also extend to humans as polymorphisms that alter circulating levels of klotho have likewise effects on lifespan and brain function. Despite the fact that modulation of klotho expression has reciprocal effects on cognitive function, …

Go to article

Novel Biomarkers For Parkinson Disease, Shijie Wang Jan 2019

Novel Biomarkers For Parkinson Disease, Shijie Wang

All ETDs from UAB

Parkinson disease (PD) is the second most common neurodegenerative disorder with no reliable biochemical biomarkers for disease prediction or progression, nor disease-modifying treatments to slow the relentless progression. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are known to increase LRRK2 kinase activity and increase the risk for late-onset PD. In this thesis, I discovered that LRRK2 is secreted into exosomes in urine and CSF, where LRRK2 kinase activity, reflected by autophosphorylation at pS1292 site, is preserved and reflective of cytosolic LRRK2 levels. In a cohort of biosamples from LRRK2 mutation carriers and matched controls, with and without PD, …

Go to article

Discovering The Genetic Architecture Underlying Exercise Response Using Drosophila Melanogaster, Louis P. Watanabe Jan 2019

Discovering The Genetic Architecture Underlying Exercise Response Using Drosophila Melanogaster, Louis P. Watanabe

All ETDs from UAB

The growth of modern jobs, technology, and transportation has coincided with increased sedentary behavior in many developed nations. In the United States, this increase has contributed partially to rising rates of obesity, leading to more than 78 million obese individuals. The annual medical costs associated with obesity are thought to range from 147 to 210 billion dollars. The initial treatment recommendations for individuals with obesity are increased exercise and changes in diet. Despite the strong narrative pushing exercise as a health benefit, individual responses can vary widely, and little is known regarding the genetic networks modulating exercise response. In order …

Go to article

Using Peptide Mimetics To Probe Protein-Protein Interactions Significant In Cancers, Robert H. Whitaker Jan 2019

Using Peptide Mimetics To Probe Protein-Protein Interactions Significant In Cancers, Robert H. Whitaker

All ETDs from UAB

Protein-protein interactions are critical for cell life. One aspect of cellular regulation where such protein-protein interactions occur is in the highly regulated process of programmed cell death (or apoptosis). Apoptosis is critical for normal tissue homeostasis, differentiation, and if dysregulated is a driver of disease including cancers. At the center of apoptotic regulation is the BCL2 protein family whose intra-familial protein-protein interactions balance cell stress signaling either allowing the cell to survive or inducing mitochondrial cell death. These BCL2 protein interactions are accomplished through the BH3 motif. While unique to the BCL2 family, a similar motif, the reverse BH3, has …

Go to article

Comparison Of Longitudinal Voxel-Based Morphometry (Vbm) And Tensor-Based Morphometry (Tbm) For Detecting Structural Use-Dependent Neuroplastic Changes After Constraint-Induced Movement Therapy, Brent Maddox Womble Jan 2019

Comparison Of Longitudinal Voxel-Based Morphometry (Vbm) And Tensor-Based Morphometry (Tbm) For Detecting Structural Use-Dependent Neuroplastic Changes After Constraint-Induced Movement Therapy, Brent Maddox Womble

All ETDs from UAB

Constraint-Induced Movement therapy (CI therapy) is an efficacious physical rehabilitation intervention for lateralized upper-extremity motor deficits resulting from neurological injury or disease, which has been shown to result in use-dependent structural and functional neuroplasticity. While use-dependent neuroplasticity has been shown to result in structural changes in brain tissue density, thickness, and volume, the exact cellular mechanisms underpinning this neuroplasticity in humans have yet to be determined. The present study involved a novel use of synthetic data, with the overall aim of elucidating the nature of structural use-dependent neuroplasticity produced by CI therapy. Longitudinal voxel-based morphometry (VBM) and tensor-based morphometry (TBM) …

Go to article

Ventral Hippocampal Input To The Medial Prefrontal Cortex Regulates Social Memory, Mary Leann Phillips Jan 2019

Ventral Hippocampal Input To The Medial Prefrontal Cortex Regulates Social Memory, Mary Leann Phillips

All ETDs from UAB

Both the ventral hippocampus (vHIP) and medial prefrontal cortex (mPFC) are active participants in the neural circuitry activated by social interaction, and are both necessary for certain aspects of social behavior. Additionally, synaptic projections from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) are implicated in several neuropsychiatric disorders. Using the Mecp2 knockout (KO) mouse model of Rett syndrome, an autism-associated disorder with network level deficits in the vHIP and mPFC as well as aberrant social behavior, we strove to determine the role of vHIP-mPFC in social behavior. Here, we show that the vHIP-mPFC projection is hyperactive in …

Go to article

The Closed Eye As A Model For Dry Eye Disease, Cameron Kenneth Postnikoff Jan 2019

The Closed Eye As A Model For Dry Eye Disease, Cameron Kenneth Postnikoff

All ETDs from UAB

Every night, during sleep, the tears of the closed eye become significantly more inflammatory, with a notable influx of neutrophils. Preliminary studies suggested that these neutrophils were significantly different than blood-isolated neutrophils, with an increased concentration, upregulated surface expression of inflammatory membrane receptors, but inability to respond to inflammatory stimuli. The purpose of this dissertation was to better understand the contribution of this neutrophil population to ocular surface homeostasis and dry eye disease. Chapter One presents an introduction to the tear film and ocular surface, along with an introduction to dry eye disease and neutrophil biology. Chapter One also discusses …

Go to article

Impact Of Environmental Exposures On Respiratory Health, Lawrence Rasmussen Jan 2019

Impact Of Environmental Exposures On Respiratory Health, Lawrence Rasmussen

All ETDs from UAB

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality around the world. Cigarette smoking is a leading cause of COPD; similarly, individuals exposed to secondhand smoke (SHS) are also vulnerable to COPD and other airway diseases; however, distinct molecular mechanisms involved in SHS-induced lung effects that result in COPD are poorly understood. Mucociliary clearance (MCC) is a primary lung defense against inhaled particulate matter and pathogens. Thus, understanding how inhaled irritants such as SHS disrupt MCC will promote improved scientific understanding and better public health initiatives to prevent respiratory illnesses. Using a variety of in vitro …

Go to article

Uncovering The Role Of Women In Two Social Movements: The Intricacies Of Black Feminine Leadership, Ajanet Schauron Rountree Jan 2019

Uncovering The Role Of Women In Two Social Movements: The Intricacies Of Black Feminine Leadership, Ajanet Schauron Rountree

All ETDs from UAB

ABSTRACT The historical conceptualization of social movements on the space-time continuum is often androcentric. Heavy reliance on male leadership perspectives negates the female point of view and creates what Marable labels an “idealized interpretation” that skirts the actual relationship between individuals and the evolution of history. This research is the deliberate recovery of the purposefully omitted while elucidating the intricacies of the leadership of Black women. It foregrounds and clarifies the leadership narratives of Black women who navigated the gendered and racialized spaces of their churches and communities in the struggle for civil and human rights during the Civil Rights …

Go to article

Enhancing Work Zone Mobility Through Design And Control Of Lane Closures, Troyee Saha Jan 2019

Enhancing Work Zone Mobility Through Design And Control Of Lane Closures, Troyee Saha

All ETDs from UAB

Work zones hinder mobility, affecting travelers and transportation agencies that are trying to ensure efficient traffic flow through work zones. A study by Wunderlich & Hardesty, 2002 reported that nearly 20% of the National Highway System roads have scheduled construction work during the peak construction season. Additionally, approximately 24% of non-recurring delays on freeways are caused by work zones. Given the time lost by travelers due to work zone induced traffic congestion, it is critically important to efficiently plan temporary traffic control (TTC) at work zones. However, earlier research conducted by Sisiopiku & Ramadan, 2017 confirms that the majority of …

Go to article

Pannexin 1 Channel Inhibition To Prevent Triggered Arrhythmia, Grace Elizabeth Salzer Jan 2019

Pannexin 1 Channel Inhibition To Prevent Triggered Arrhythmia, Grace Elizabeth Salzer

All ETDs from UAB

The mechanism of triggered arrhythmia generation involves inappropriate diastolic calcium (Ca2+) releases from the sarcoplasmic reticulum that promote membrane depolarization when the released Ca2+ is transported out of the cardiomyocyte via the sodium Ca2+ exchanger (NCX). If membrane depolarization is large enough, these events can trigger an ectopic action potential. However, it is not fully understood what physiological factors facilitate triggered events at the tissue level. Pannexin 1 (Px1), a large transmembrane conductance channel, can be activated by various stimuli including increases in intracellular Ca2+. We predict that during diastolic Ca2+ releases, Px1 becomes activated and together with the NCX, …

Go to article

Transcriptional Dynamics Of Dopaminergic Signaling, Katherine Elizabeth Savell Jan 2019

Transcriptional Dynamics Of Dopaminergic Signaling, Katherine Elizabeth Savell

All ETDs from UAB

Drugs of abuse increase dopamine concentrations in the nucleus accumbens, a key reward structure that integrates contextual and cue-related information and regulates motivated behavior. This surge of dopamine triggers cell signaling cascades that converge in the nucleus to cause changes in gene expression, which are thought to lead to the observed functional and structural alterations in the reward circuit after exposure to drugs of abuse. However, while various drugs of abuse cause transcriptional changes, previously available tools have not had the capacity to deeply characterize these gene programs. Therefore, we optimized a dual lentivirus CRISPR system for targeted gene modulation …

Go to article

Intracellular Compartment-Specific Abnormalities In Proteasome Expression And Activity In The Superior Temporal Gyrus In Schizophrenia, Madeline R. Scott Jan 2019

Intracellular Compartment-Specific Abnormalities In Proteasome Expression And Activity In The Superior Temporal Gyrus In Schizophrenia, Madeline R. Scott

All ETDs from UAB

Protein homeostasis is an emerging component of schizophrenia (SZ) pathophysiology. Proteomic alterations in SZ are well-documented; however the underlying mechanism driving these changes remains unknown. The ubiquitin proteasome system (UPS) is fundamental to protein homeostasis regulation, and UPS transcript abnormalities in both blood and brain have been observed in SZ. Supporting a role for UPS dysfunction in SZ, we have reported decreased protein expression of ubiquitin-associated proteins in SZ brain. However, previous work on the proteasome has been limited to transcript expression. In the following studies we sought to address this gap in knowledge by characterizing proteasome dysfunction in the …

Go to article

Novel Approaches To Enhance Translational Readthrough Efficacy For Cystic Fibrosis Nonsense Mutations, Jyoti Sharma Jan 2019

Novel Approaches To Enhance Translational Readthrough Efficacy For Cystic Fibrosis Nonsense Mutations, Jyoti Sharma

All ETDs from UAB

Cystic fibrosis (CF) is a monogenic autosomal recessive disease caused by over 1,900 naturally occurring variants in the CF transmembrane conductance regulator (CFTR). CFTR is an epithelial anion channel which regulates the movement of chloride and bicarbonate ions. Mutations in the CFTR causes diminished CFTR protein and/or reduced CFTR function that lead to clinical manifestations. These include severe epithelial dysfunction of multiple tissues, including the lungs, intestine, pancreas, and reproductive organs. Premature termination codons (PTC), or nonsense mutations, are among the most severe CFTR variants and occur in ~11% of the CF population. PTCs are caused by the presence of …

Go to article

Perceptions Of African-American Teachers Concerning African-American Youth, D'Antranett Hicks-Stewart Jan 2019

Perceptions Of African-American Teachers Concerning African-American Youth, D'Antranett Hicks-Stewart

All ETDs from UAB

Perceptions of African American youth have been illustrated by how they are perceived on television: as deviants, criminals and unteachable. These perceptions are also illustrated in the behaviors of teachers in both inner-city and suburban schools. African American teachers in the inner-city schools have hope of changing the world for the better until they are met with difficult challenges presented by African-American students. Some students are excellent and some not so excellent. The structural environment of African-American youth can so strongly influence their behavior, that they begin to take on their perceptions. This can be seen in their choice friends, …

Go to article

Wear Of Orthodontic Bite Turbos And Opposing Enamel, Kyle Feagin Jan 2019

Wear Of Orthodontic Bite Turbos And Opposing Enamel, Kyle Feagin

All ETDs from UAB

Orthodontic bite turbos are used to separate the maxillary and mandibular arches when disocclusion is needed for facial placement of orthodontic brackets or extrusion of teeth. The bite turbo should have adequate wear resistance to maintain the disocclusion but also avoid abrasion of the opposing enamel. The objective of this study was to measure the wear and opposing enamel wear of three materials used as bite turbos. 8 specimens (10x8x4 mm) each of Transbond LR (3M), Transbond Plus (3M) and Triad gel (Dentsply) were prepared in silicone molds and light cured for 30 seconds using an Acteon Satelec Blue Ray …

Go to article

Regulation Of St6gal-I In Cancer: Sox2 Identified As Novel Driver Of St6gal-I Expression, Kaitlyn Alexandra Dorsett Jan 2019

Regulation Of St6gal-I In Cancer: Sox2 Identified As Novel Driver Of St6gal-I Expression, Kaitlyn Alexandra Dorsett

All ETDs from UAB

ST6Gal-I is a sialyltransferase that functions to add an 2-6 linked sialic acid to N-linked glycoproteins. The expression of ST6Gal-I is upregulated in many cancers at both the mRNA and protein levels. ST6Gal-I has also been shown to promote cancer stem cell (CSC) characteristics including chemoresistance, tumor-initiating potential, and spheroid growth. However, the transcriptional drivers of ST6Gal-I expression in stem-like cells remain largely unknown. Herein we highlight that SOX2 and ST6GAL1 are both located on one of the most commonly amplified chromosomal segments in cancer, amplicon 3q26. Copy number gains in both SOX2 and ST6GAL1 are observed in roughly 25% …

Go to article

Identification Of Two Spop-Mediated Pathways In Prostate Cancer Progression, Joshua Fried Jan 2019

Identification Of Two Spop-Mediated Pathways In Prostate Cancer Progression, Joshua Fried

All ETDs from UAB

Prostate cancer is one of the most common malignancies and causes of cancer related death in men. Morbidity is primarily attributed to late-stage and metastatic disease. Re-cent genomic screening studies have revealed that the Speckle type Poz Protein (SPOP) is the most frequently altered gene by missense mutations in prostate cancer. Interestingly, all of the identified mutations were located in the substrate binding domain of SPOP. Here, two pathways highlighting the impact of SPOP mutation on prostate cancer are pre-sented. First, evidence showing that one of the naturally occurring SPOP mutations, ser-ine 119 to asparagine (S119N), induces radiosensitivity and an …

Go to article

The Role Of Nudc In Rod Photoreceptor Cell Maintenance: A New Function For An Old Protein, Evan Boitet Jan 2019

The Role Of Nudc In Rod Photoreceptor Cell Maintenance: A New Function For An Old Protein, Evan Boitet

All ETDs from UAB

The overall health and maintenance of rod photoreceptors depends on directed vectorial transport of rhodopsin from its synthesis within the inner segment to its target destination the outer segment disk membranes. Numerous proteins are known to be involved in molecular interactions with rhodopsin during transport, including the interaction of nuclear distribution protein C (nudC) with rhodopsin that was first described in Xenopus laevis. We found that the interaction of nudC and rhodopsin is conserved in mammalian retina. This interaction is direct and aberrant expression of nudC results in subcellular localization of rhodopsin. We show for the first time that nudC …

Go to article

First Prev Next Last