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Glycoprotein 340 Expression In Dry Eye Disease And Ocular Surface Infection, Kwaku Antwi Osei Jan 2021

Glycoprotein 340 Expression In Dry Eye Disease And Ocular Surface Infection, Kwaku Antwi Osei

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Glycoprotein 340 (Gp340) is a 340-kDa multi-domain pattern recognition receptor (PRR) belonging to the scavenger receptor cysteine-rich superfamily of proteins. On the ocular surface, Gp340 is expressed in the tear film, lacrimal gland, cornea, and conjunctiva. By their nature, PRRs detect pathogen-associated molecular patterns (PAMPs) on microbial organisms and damage-associated molecular patterns (DAMPs) released from injured, stressed, necrotic, and apoptotic cells. This, in turn, induces the expression of nuclear factor-κB- and the interferon regulatory factor-dependent expression proinflammatory cytokines and chemokines, eliciting both innate and adaptive immune response activation. Thus, as a PRR, Gp340 has the potential to modulate microbial infection …

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Evaluating The Regulation And Effect Of Innate Immune Gene Expression On Melanocyte Biology, Alex D. Dawson Jan 2021

Evaluating The Regulation And Effect Of Innate Immune Gene Expression On Melanocyte Biology, Alex D. Dawson

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Anecdotally, humans can experience loss of hair color or hair graying after infection or vaccination yet our understanding of how melanocyte biology and the innate immune system interact is incomplete. Mouse models of hair graying have been used to reveal numerous mechanisms that adversely affect the melanocyte system within the hair follicle, and one such mouse model highlights a molecular link between the transcription factor SOX10, melanogenesis and innate immune dysregulation. SOX10 is a transcription factor critical for neural crest development and melanogenesis, and when overexpressed in the Tg(Dct-Sox10)CF1-10 mouse line causes a sensitivity to viral mimic Poly(I:C) that results …

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Transcriptional Regulation And Islet Transplantation Advantages Of Brown Adipose Tissue, Jessica D. Kepple Jan 2021

Transcriptional Regulation And Islet Transplantation Advantages Of Brown Adipose Tissue, Jessica D. Kepple

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Metabolic disease encompasses various disorders, including obesity and diabetes, that negatively impact glucose and lipid homeostasis and increase the risk of co-morbidities. Adipose tissue, which regulates whole-body energy balance and acts as a specialized endocrine tissue, is negatively affected by obesity and diabetes. Brown adipose tissue (BAT) functions to dissipate excess energy as heat and therefore is an attractive target against metabolic disease. To develop more effective therapeutic strategies, BAT physiology and genetic regulatory mechanisms need to be better understood. This dissertation highlights studies seeking to illuminate novel transcriptional regulation and islet transplantation applications of BAT. We investigated the requirement …

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De Novo Generation Of Cardiomyocytes For Regenerative Medicine Treatment, Yawen Tang Jan 2021

De Novo Generation Of Cardiomyocytes For Regenerative Medicine Treatment, Yawen Tang

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Cardiovascular disease, till now, is still the leading cause of death in the United States. As a consequences of heart attack event, cardiomyocytes death is an irreversible process accompanied with scar formation and loss of heart function. As mammalian cardiomyocytes exit cell cycle shortly after birth, with no replacement of the necrotic cardiomyocytes, the damages caused by heart attack often progress into more severe symptoms such as heart failure. To replenish damaged cardiomyocytes (CMs), many therapies, such as differentiate the induced pluripotent stem cells (iPSCs) into cardiomyocytes and direct reprogram fibroblasts into CMs, have been developed. During this dissertation study, …

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Analysing The Contribution Of Snare-Dependent Exocytosis From Astrocytes To Huntinton's Disease Pathogenesis Using The Bachd Mouse Model, Annesha C. King Jan 2021

Analysing The Contribution Of Snare-Dependent Exocytosis From Astrocytes To Huntinton's Disease Pathogenesis Using The Bachd Mouse Model, Annesha C. King

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Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. Multiple studies have indicated the importance of mutant huntingtin (mHTT) in astrocytes to HD pathogenesis. Increased extracellular glutamate levels were observed after evoking SNARE-dependent exocytosis from cultured mHTT expressing astrocytes. To determine whether astrocytic SNARE-dependent exocytosis contributed to behavioral and neuropathological changes in vivo, we crossed BACHD mice to dominant negative SNARE (dnSNARE) mice and analyzed behavioral and neuropathological phenotypes. First, we found that reduc-ing astrocytic SNARE-dependent exocytosis had differential effects on the psychiatric-like and motor phenotypes observed in BACHD mice where …

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The Assessment Of Neuro-Mechanics Of Inspiratory Muscles During Mechanical Ventilation, Hassan Y. Abunurah Jan 2021

The Assessment Of Neuro-Mechanics Of Inspiratory Muscles During Mechanical Ventilation, Hassan Y. Abunurah

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The decline in inspiratory muscles function for patients undergoing mechanical ventilation may further extend the duration of mechanical ventilation leading to lethal complications. Thus, the assessment of neuro-mechanics of inspiratory muscles may help us understand the pathophysiology for mechanical ventilation failure to avoid its complications. In this dissertation, we assessed the characteristics of inspiratory neuromechanics under different conditions. This dissertation is reported in three different papers. In the first paper, we sought to assess the quality of the available literate that used surface EMG of extra-diaphragmatic muscles during invasive mechanical ventilation. We demonstrated that the use of sEMG of extra-diaphragmatic …

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From Classrooms To Polluted Communities: Scientific Inquiry In Birmingham, Alabama And Beyond, Sarah Jeanne Adkins-Jablonsky Jan 2021

From Classrooms To Polluted Communities: Scientific Inquiry In Birmingham, Alabama And Beyond, Sarah Jeanne Adkins-Jablonsky

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Nearly half of all U.S. students who declare science majors in college do not graduate with science degrees within six years. Improvements in science outcomes are linked with active-learning pedagogies such as Course-based Undergraduate Research Experiences (CUREs). However, despite the need for education reform particularly in Alabama, active-learning interventions are severely understudied in Alabama universities. Chapter 1 describes novel CUREs at four colleges in Birmingham, AL: The University of Alabama at Birmingham (UAB); Jefferson State Community College (JSCC), Samford University (SU), and Birmingham Southern College (BSC). Chapter 2 shows how an agar art CURE, The Art of Microbiology, impacts student …

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Joint Specificity Of Stretch-Shortening Cycle Potentiation, Marzouq Khalaf Almutairi Jan 2021

Joint Specificity Of Stretch-Shortening Cycle Potentiation, Marzouq Khalaf Almutairi

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The stretch-shortening cycle (SSC) is a well-known phenomenon to enhance an individual’s muscular performance, and it is an area of active focus of research scientists for decades. However, it is not known whether SSC potentiation is a joint-specific event and shows a joint-specific temporal behavior. It is also unclear if constraints of joint and movement specificity of SSC potentiation can be captured via isokinetic dynamometer. Therefore, the purposes of this dissertation were to examine joint specificity of SSC potentiation via isokinetic dynamometer and kinetic-kinematic analysis of jump test performance and investigate joint-specific temporal behavior of SSC potentiation. My first study …

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Socioeconomic Status In Adolescence And Dna Methylation In Young Adulthood, Malcolm Barker-Kamps Jan 2021

Socioeconomic Status In Adolescence And Dna Methylation In Young Adulthood, Malcolm Barker-Kamps

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Children from low socioeconomic status (SES) families are at a greater risk of negative health outcomes in adulthood, in part from chronic stress. The chronic stress of these experiences may become biologically embedded through DNA methylation in stress-related genes. However, the effects of specific SES dimensions during childhood or adolescence on later epigenetic profiles in adulthood are not well understood. The present study examined the roles of two objective SES dimensions and two subjective SES dimensions experienced in early adolescence in DNA methylation in young adulthood. The analyses focused on two genes, NR3C1 and SLC6A4, because their methylation has been …

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Beyond Apoptosis: Insight Into The Complex Intracellular Networks That Govern Cell Fate, Hayley Neal Widden Jan 2021

Beyond Apoptosis: Insight Into The Complex Intracellular Networks That Govern Cell Fate, Hayley Neal Widden

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The determination of cell fate is a dynamic process regulated by hundreds of proteins that converge into complex cell signaling pathways. Upon irreparable intracellular stress, a cell undergoes programmed cell death, a process known as intrinsic apoptosis. Apoptosis is regulated by the Bcl-2 family, a class of proteins that act either as pro-survival or pro-death signaling molecules. Due to the oncogenic upregulation of pro- survival Bcl-2 family proteins across human cancer cell types, a novel class of small molecule inhibitors called ‘BH3-mimetics’ have emerged as promising anti-cancer therapeutics currently under clinical investigation. Here, we highlight the crosstalk between anti-apoptotic Bcl-2 …

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Importance Of The Zebrafish Model For Understanding Nutrition, Michael Britt Williams Jan 2021

Importance Of The Zebrafish Model For Understanding Nutrition, Michael Britt Williams

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The common zebrafish Danio rerio is a useful model for human health. Effective utilization of this model required development of husbandry and reproductive protocols as well as genomic sequencing and creation of relevant molecular techniques. However, the dietary needs of the species remain woefully under investigated. At this time no chemically-defined open source diets are available to the zebrafish research community. Consequently, those labs utilizing the zebrafish model rely on commercial diets that may not provide adequate nutrition and lack consistency needed for rigorous and reproducible research. The first focus of these studies was to examine the current state of …

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Hyperphosphatemia Contributes To Functional Iron Deficiency And Skeletal Muscle Wasting, Brian Anthony Czaya Jan 2021

Hyperphosphatemia Contributes To Functional Iron Deficiency And Skeletal Muscle Wasting, Brian Anthony Czaya

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Chronic kidney disease (CKD) is a global health threat that increases risk of death, which is credible to both impaired renal function and a multitude of CKD- associated comorbidities such as systemic inflammation, anemia and skeletal muscle dys- function. A distinctive feature of CKD is the dysregulation of mineral metabolism, where excess serum levels of phosphate (hyperphosphatemia) and of fibroblast growth factor 23 (FGF23) are not only viewed as biomarkers for disease severity but also exert deleterious effects towards various CKD-associated pathologies. Elevated levels of FGF23 can lead to the activation of FGF receptor 4 (FGFR4) in cell types that …

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Targeting Oncogenic Microrna In Lung Cancer, Mackenzie Lauren Davenport Jan 2021

Targeting Oncogenic Microrna In Lung Cancer, Mackenzie Lauren Davenport

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Lung cancer is the leading cause of cancer-related death both in the United Statesand the world. While several genetic drivers of lung cancer have been identified, major improvements in patient outcome are lacking, highlighting the need to further understand the genetic and molecular mechanisms of this disease. The microRNA miR-31 has been implicated in oncogenesis in a variety of cancer types, and prior data from our laboratory has shown it to be overexpressed in human lung adenocarcinoma tumors compared to normal lung, high miR-31 levels correlate with decreased patient survival, and overexpression of miR-31 alone in the mouse lung epithelium …

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Upregulation Of Somatostatin Receptor 2 In Neuroendocrine Tumors Using Histone Deacetylase Inhibitors, Rachael Elizabeth Guenter Jan 2021

Upregulation Of Somatostatin Receptor 2 In Neuroendocrine Tumors Using Histone Deacetylase Inhibitors, Rachael Elizabeth Guenter

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Neuroendocrine cancer is complex disease of the diffuse neuroendocrine system. Neuroendocrine tumors (NETs) can arise throughout the body, including the lungs and pancreas. These tumors are phenotypically and genetically heterogeneous, making accurate diagnoses difficult with current imaging standards. New diagnostic options, coupled with a better understanding of neuroendocrine cancer etiology, is urgent and necessary to provide patients with better futures. Many NETs overexpress somatostatin receptor 2 (SSTR2) on their cellular surfaces, making patients eligible for [68Ga]-DOTATATE PET/CT imaging and SSTR2-based therapies. However, patients that lack sufficient SSTR2 overexpression cannot benefit from SSTR2-targeted imaging or therapeutic options. We found that histone …

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The Effects Of A Social Skills Intervention On Neural Processing In Autism Spectrum Disorder, Abbey Jane Herringshaw Jan 2021

The Effects Of A Social Skills Intervention On Neural Processing In Autism Spectrum Disorder, Abbey Jane Herringshaw

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Difficulties in social interaction are considered a core characteristic of autism spectrum disorders (ASD) and have significant negative effects on quality of life in this population. Such deficits may reflect alterations in key areas of the “social brain” in ASD. Many clinical interventions for ASD seek to improve social interaction abilities, including the Program for Education and Enrichment of Relational Skills (PEERS®). PEERS® has demonstrated significant benefits for participants, but little is known about: 1) generalizability of the specific social knowledge gained to broader social cognitive processes, and 2) potential neuroplastic changes within the social brain in response to social …

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A Randomized Controlled Trial To Compare The Histomorphometric And Clinical Outcomes Of Soft Tissue Augmentation At The Time Of Lateral Ridge Augmentation Procedures, Kenneth Liu Jan 2021

A Randomized Controlled Trial To Compare The Histomorphometric And Clinical Outcomes Of Soft Tissue Augmentation At The Time Of Lateral Ridge Augmentation Procedures, Kenneth Liu

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Guided bone regeneration (GBR) can be used to augment deficient alveolar ridges in preparation for dental implant placement. Mucogingival deformities can result from the periosteal releasing incision during GBR. This can be addressed by additional soft tissue augmentation procedures to increase the width of keratinized tissue and vertical soft tissue thickness, both of which have demonstrated clinical benefits around implants. The drawbacks of soft tissue augmentation following ridge augmentation include an additional procedure, increased patient morbidity, and less patient acceptance of treatment. In general, soft tissue augmentation can be performed at various time points throughout treatment, but literature on soft …

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An Analysis Of The Relationship Between Student Achievement And The Emotional Intelligence Quotient Of Secondary Principals In Alabama Schools, Dorothiann Martin Jan 2021

An Analysis Of The Relationship Between Student Achievement And The Emotional Intelligence Quotient Of Secondary Principals In Alabama Schools, Dorothiann Martin

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This dissertational work provides an analysis between school leader emotional intelligence and academic achievement using selected indicators of student achievement in Alabama high schools. Emotional intelligence levels were measured by administering The Shutte Self-Report Emotional Intelligence Test to willing high school principal participants in the state of Alabama. The student achievement measures include: (a) high school graduation rate, (b) performance on the American College Test (ACT), and (c) chronic student absenteeism. After running several numerical analyses between emotional intelligence (independent variable) and student achievement (dependent variable) and controlling for certain subpopulations, the statistical analyses data revealed that there were no …

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Characterization Of The Metabolic And Cognitive Features Of A Novel Alzheimer’S Disease Rat Model Along With Investigation Of Its Gut Microbiota Change Over Time, Akash Nagarajan Jan 2021

Characterization Of The Metabolic And Cognitive Features Of A Novel Alzheimer’S Disease Rat Model Along With Investigation Of Its Gut Microbiota Change Over Time, Akash Nagarajan

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Alzheimer’s disease (AD) is currently the fifth highest cause of death in the United States and affects primarily individuals of very old age (>80 yrs.). Aging is known to be the biggest risk factor of AD. Recent studies have shown that AD patients have an altered gut microbiota composition. To investigate whether the Alzheimer’s disease pathology in the brain could drive gut microbiota changes during the adult and late life stage of the rat, we performed 16S ribosomal RNA sequencing on the fecal samples of the animals at 14 months and 20 months of age. We found a distinctive …

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Modification Of N95 Respirators: Allaying Deficits In Respiratory Protection Below 300 Nanometers, Adam Nored Jan 2021

Modification Of N95 Respirators: Allaying Deficits In Respiratory Protection Below 300 Nanometers, Adam Nored

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The current growth rate of nanomaterials being used in everyday materials as well as in construction materials is quite large. While this in itself could be quite promising, there is a lack of information known about the risks that materials in the nano size range may have attached to their use. Until a full-scale risk analysis of the nanomaterials is used in the construction industry there is a need for personal protection to be implemented. A known issue with the current PPE exists, in that the N95 personal respirator has some particle collection efficiency issues below 300 nm. Modifications to …

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Teaching Historical Skills Using Monuments, Markers, And Online Museums, James David Nunez Jan 2021

Teaching Historical Skills Using Monuments, Markers, And Online Museums, James David Nunez

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ABSTRACT The nation is embroiled within intense debate regarding the existence of monuments, markers, and online museums as vestiges of racism and White privilege. Many argue those symbols should be removed from the public square. The essential question of this research is what are social studies methods teachers’ perspectives about using monuments, markers, and online museums (3M) as teaching tools to prepare pre-service teachers to utilize historical thinking skills? This study was designed in part to re-tool a traditional interpretation of controversial 3M artifacts that deal honestly with memory, providing learners a compelling motivation to explore history that promotes greater …

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Evaluation Of Antimicrobial Effect Of Licorice Extrcat Agiasnt Oral Microorganisms, Roshanak Rastegar Jan 2021

Evaluation Of Antimicrobial Effect Of Licorice Extrcat Agiasnt Oral Microorganisms, Roshanak Rastegar

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Introduction: The causative factors of dental caries have been studied for many years, however, preventing the formation of dental caries remains an elusive task. Microorganisms have been the focal point of numerous studies as a prime cariogenic factor. Streptococcus mutans and Candida albicans have been frequently co-isolated from dental biofilm in patients with early childhood caries (ECC) and studies have demonstrated the synergistic effects of these two microorganisms in promoting tooth demineralization. Acid and glucan production, which are two virulence factors produced by S. mutans that mediate biofilm formation and tooth decay, have been shown to be promoted during co-colonization …

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Mechanism Of Stat3 Mediated Drug Persistence In Chronic Myeloid Leukemia Stem Cells, Sweta B. Patel Jan 2021

Mechanism Of Stat3 Mediated Drug Persistence In Chronic Myeloid Leukemia Stem Cells, Sweta B. Patel

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Drug persistence is one of the major impediments for cancer therapeutics. There are two known evolutionary models for tumor drug persistence. First, a pre-existing sub-population is inherently resistant to treatment; and second, a sub-population acquires resistance by drug-induced molecular reprograming. One ideal model to study the mechanism of drug persistence is chronic myeloid leukemia (CML), a hematopoietic stem cell (HSC) disorder. HSCs acquire a single translocation between chromosome 9 and 22, forming BCR-ABL, a constitutively active tyrosine kinase. Tyrosine kinase inhibitors (TKI), the standard regimen, have been able to efficaciously control CML and yet many patients relapse upon treatment discontinuation …

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Waffle, Ashley Tippit Jan 2021

Waffle, Ashley Tippit

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Waffle is a novel about a high school senior realizing she has an anxiety disorder and is pansexual. Aside from wanting to tell a version of my own story, I want this to be a young adult novel that has appropriate, diverse representation. Given that several characters have identities different than mine (Jay having a single parent, Ginger being Black and having Type One Diabetes, Ella being transgender with divorced parents, and Birdie being Taiwanese-Korean American), I will need a lot of research and help to write these characters well. I want the information and experiences regarding race, gender, sexuality, …

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An Investigation Into The Effects Of Diet On Pain And Pain Disparities, Larissa Jane Strath Jan 2021

An Investigation Into The Effects Of Diet On Pain And Pain Disparities, Larissa Jane Strath

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Chronic pain is one of the most common and disabling disorders in Westernsociety. Recently, it has been suggested that dietary quality may play a key role in the development and maintenance of pain. Additionally, diet differs between demographic groups, as does physiological differences in response to metabolites. We sought to explore 1) the central way in which diet influences pain sensitivity and 2) if dietary patterns affected various demographic groups differently. We first employed a rat model to observe diet-related changes in the dorsal horn of the spinal cord. In the absence and presence of an injury, rats fed a …

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Characterizing The Role Of Necroptosis Of Airway Epithelial Cells In The Immune Response To Respiratory Pathogens, Ashleigh Nichole Riegler Jan 2021

Characterizing The Role Of Necroptosis Of Airway Epithelial Cells In The Immune Response To Respiratory Pathogens, Ashleigh Nichole Riegler

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Necroptosis, a programmed form of lytic cell death, is initiated by various viral and bacterial pathogens through irreparable ion dysregulation and energy depletion. This cellular damage results in the activation of the cellular kinases RIPK1 and RIPK3, consecutively, and the activation and membrane targeting of MLKL, the latter responsible for lysis. Here we have demonstrated that necroptosis of airway epithelial cells is key in the development of the adaptive immune response to asymptomatic colonization by Streptococcus pneumoniae (Spn). Briefly, necroptotic deficient animals or wildtype animals colonized with Spn lacking the necroptosis-triggering pneumolysin toxin, failed to recruit CD11c+ leukocytes to the …

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Cns Antigen Presentation And Immune Cell Infiltration In An Α-Syn Model Of Parkinson Disease, Aubrey Michelle Schonhoff Jan 2021

Cns Antigen Presentation And Immune Cell Infiltration In An Α-Syn Model Of Parkinson Disease, Aubrey Michelle Schonhoff

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Parkinson disease (PD) is a neurodegenerative movement disorder that is characterized by aggregated alpha-synuclein (a-syn), loss of dopaminergic neurons, and neuroinflammation. This neuroinflammation includes the activation of immune cells that reside in the CNS, such as microglia and border associated macrophages (BAMs), in addition to the infiltration of peripheral leukocytes and increased cytokine and chemokine production. Because of the involvement of both the innate and adaptive immune systems, we sought to investigate their interaction through antigen presentation and determine what role this played in disease progression. Using an a-syn based mouse model of PD, our studies have provided evidence via …

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Development And Evaluation Of A Functional Human Cardiac Tissue Equivalent Fabricated From Multi-Lineage Human Induced Pluripotent Stem Cell Derived Cells, Danielle Pretorius Jan 2021

Development And Evaluation Of A Functional Human Cardiac Tissue Equivalent Fabricated From Multi-Lineage Human Induced Pluripotent Stem Cell Derived Cells, Danielle Pretorius

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The human heart is an exceptionally complex muscular organ that is vital for survival. Electrical impulses signal activation of mechanical contractions, pumping blood through the entire body and allowing for oxygen-exchange to occur. Unfortunately, certain disease states or traumatic injuries such as myocardial infarctions hamper the heart’s efficiency and function by damaging its structure. Ideal treatment would allow for the replacement or regeneration of the damaged tissue with cells and material harvested from the patient, thus avoiding the potential for immune rejection. Engineered cardiac tissues fabricated from human induced pluripotent stem cells have shown great promise for restoring function in …

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Neonatal Murine Cytomegalovirus Infection Disrupts Synapse Remodeling During Development, Jerome Moulden Jan 2021

Neonatal Murine Cytomegalovirus Infection Disrupts Synapse Remodeling During Development, Jerome Moulden

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Human cytomegalovirus (HCMV) is a complex double stranded DNA betaherpesvirus. Its linear DNA in enclosed in an icosahedral capsid, and has a genome size of about 230kb and encodes about 170 genes. Primary infection with HCMV lead to a lifelong persistent infection. HCMV can also be transmitted across the placenta and infect the developing fetus leading to infection of the newborn infant, an infection which is commonly described as congenital HCMV infection. In the United States, the prevalence of congenital HCMV infection is between 0.2-1.2%. Approximately 5-15% of these newborn infants will develop long-term neurological damage resulting, motor disorder, cognition …

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Studies On Nontypeable Haemophilus Influenzae Biofilm Persistence & Redox Homeostasis In Chronic Bacterial Diseases, Benjamin C. Hunt Jan 2021

Studies On Nontypeable Haemophilus Influenzae Biofilm Persistence & Redox Homeostasis In Chronic Bacterial Diseases, Benjamin C. Hunt

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Bacterial biofilms, or surface-adherent bacterial communities surrounded by a self-produced extracellular polymeric matrix, are ubiquitous. They are found throughout Earth’s ecosystems, in the soil and waterways, and more pressingly for the medical community, they are found within humans. Bacterial biofilms are associated with a multitude of diseases and their involvement significantly complicates treatment given that bacteria growing within a biofilm are extremely more resistant to antibiotics and immune effectors. Thus, the need to better understand biofilm biology and find ways to disrupt and/or sensitize biofilms to medical treatment is significant. The goal of the research presented herein was to investigate …

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Tau-Sh3 Interactions And Alzheimer's Disease, Jonathan Roth Jan 2021

Tau-Sh3 Interactions And Alzheimer's Disease, Jonathan Roth

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Alzheimer’s disease (AD) is the most common neurodegenerative disorder worldwide, and its impact will increase with an aging population. It is characterized by dementia associated with accumulation of extracellular amyloid-β (Aβ) plaques, intracellular hyperphosphorylated Tau tangles, and neurodegeneration. Additionally, network hyperexcitability occurs early in AD and likely contributes to disease pathogenesis. Current therapies provide minor delay of disease progression at best, so it is imperative to develop novel therapeutic approaches to prevent and treat AD. As Tau pathology correlates better with cognitive function than Aβ pathology and Tau reduction prevents Aβ-induced dysfunction in preclinical models, targeting Tau is a growing …

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