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The Role Of The Bone Marrow Microenvironment In Flt3-Itd Acute Myeloid Leukemia Stem Cell Resistance To Flt3 Inhibition, Nicholas R. Anderson Jan 2022

The Role Of The Bone Marrow Microenvironment In Flt3-Itd Acute Myeloid Leukemia Stem Cell Resistance To Flt3 Inhibition, Nicholas R. Anderson

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Acute myeloid leukemia (AML) is an aggressive, complex hematological malignancy. AML cases with constitutively-activating internal tandem duplications in the Flt3 receptor (Flt3-ITD) represent a distinct subtype of disease with poor prognosis, but unique opportunities for targeted therapy. Flt3-specific tyrosine kinase inhibitors (TKI) have entered clinical practice due to their ability to induce remissions in a large proportion of Flt3-mutant AML patients, but their long-term efficacy remains limited due to the persistence of leukemia stem cells (LSC) in the bone marrow (BM). Herein, we outline the importance of the bone marrow microenvironment (BMM) in harboring LSC through AML development and drug …

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A Hybrid Data And Hypothesis-Driven Model For Software Development In Support Of The Machine-Learning Paradigm, Anthony D. Bowman Jan 2022

A Hybrid Data And Hypothesis-Driven Model For Software Development In Support Of The Machine-Learning Paradigm, Anthony D. Bowman

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istorically, research has often been conducted in a hypothesis-driven manner with software development methodologies created to support those efforts. However, in recent years data-driven approaches to research have seen a dramatic rise in prominence. While software development methodologies such as agile development, extreme programming, and the waterfall model have allowed developers to tackle increasingly complex problems, they were not designed to efficiently support data-driven approaches such as the machine learning paradigm. To address the need to support the different programmatic requirements of both classical, hypothesis-driven as well as data-driven development, novel development strategies are warranted. In this research, we adapted …

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Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas Jan 2022

Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas

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of ALL survivors are at risk for reduced functional outcomes, and these outcomes may be more strongly related to executive functioning than neighborhood-specific variables or IEP support. Long-term goals include translating findings into practice to remediate adaptive or academic difficulties in ALL survivors.

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Monoclonal Antibody-Mediated Cancer Treatment: Development, Manufacturing And Evaluation, Yingnan Si Jan 2022

Monoclonal Antibody-Mediated Cancer Treatment: Development, Manufacturing And Evaluation, Yingnan Si

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Malignant cancer is one of the greatest threats to human health globally. Conventional (non-targeted) treatments such as chemo-drugs and radiation therapy remain the major choices for cancer patients while always accompanied by severe systemic toxicity/side effects. Monoclonal antibody (mAb) is one of the most successful biomolecules discovered and well investigated as a targeted therapy to treat human disease. This dissertation research was aimed to develop monoclonal antibody-based targeted drugs for cancer treatment, which include antibody-drug conjugates (ADCs), liposomal drug and exosome-based drug delivery. Novel targets were discovered, screened and confirmed by proteomics, western blotting and flow cytometry analysis. Cancer cells …

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Preventing Unintentional Childhood Injuries In Rural Uganda: Caregiver Perceptions And Promotion Of Personal Safety Skills Through Classroom-Based Instruction, Marissa H. Swanson Jan 2022

Preventing Unintentional Childhood Injuries In Rural Uganda: Caregiver Perceptions And Promotion Of Personal Safety Skills Through Classroom-Based Instruction, Marissa H. Swanson

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Objective: Unintentional childhood injuries present a substantial public health burden in low- and middle-income countries (LMIC) including Uganda. Interventions to reduce this risk should be responsive to children’s unique developmental, environmental, and sociocultural context. This project had three primary objectives: 1) Analyzing caregiver reports of child injury events in rural Uganda to identify perceived causal and preventative factors; 2) Identifying Ugandan first and sixth graders’ developmental safety needs by comparing hazard recognition and past-year injuries among these students; and 3) Evaluating the impact of the Careful Cubs intervention on Ugandan first graders’ personal safety knowledge, skills, and beliefs. Methods: 1) …

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Understanding The Protumorigenic Functions Of St6gal1 In Glioblastoma Stemness And Metabolism, Sajina Gc Jan 2022

Understanding The Protumorigenic Functions Of St6gal1 In Glioblastoma Stemness And Metabolism, Sajina Gc

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Glioblastoma (GBM) is a rare but deadly cancer with median survival of just 15 months despite of aggressive treatment. Advancement in novel treatment modalities is hindered by its heterogeneous nature, which includes subsets of neural stem cell-like brain tumor initiating cells (BTICs) that are highly tumorigenic and therapy-resistant. bgalactoside a-2,6-sialyltransferase 1 (ST6Gal1) is elevated in most tumors including in normal and neoplastic stem cells. ST6Gal1 imparts oncogenic phenotypes such as invasion, apoptosis evasion, therapy resistance, TIC maintenance among others via sialylation of critical receptors like, Fas, TNFR1, EGFR and more. Yet ST6Gal1 led regulation of BTIC specific cell surface proteins …

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The Evolutionary Ecology Of The Antarctic Red Macroalga Plocamium Sp. In Relation To Its Defensive Secondary Metabolite Diversity, Sabrina Heiser Jan 2022

The Evolutionary Ecology Of The Antarctic Red Macroalga Plocamium Sp. In Relation To Its Defensive Secondary Metabolite Diversity, Sabrina Heiser

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Organisms produce chemical defenses to gain a competitive advantage, and to protect themselves from pathogens and predators. There is high inter- and, sometimes, intraspecific diversity in the types and quantities of defensive secondary metabolites. Yet, we do not know much about the mechanisms driving the diversity and its distribution. Macroalgae are important members of ecosystems since they provide living space and are primary producers. To prevent predation, macroalgae make structural or chemical defenses. Chemical defenses in the Antarctic red macroalga Plocamium sp. have extensively been studied. It is widespread along the western Antarctic Peninsula and abundant at sites where it …

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The Role Ofbiomechanics In Vascular Endothelial Growth Factor Receptor-2 Signaling, Bronte Miller Jan 2022

The Role Ofbiomechanics In Vascular Endothelial Growth Factor Receptor-2 Signaling, Bronte Miller

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Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. When a tumor is small, diffusion is sufficient to receive essential nutrients; however, as the tumor grows a vascular supply is needed to deliver oxygen and nutrients into the increasing mass. Several anti-angiogenic cancer therapies target VEGF and its receptor VEGFR-2, which are major promoters of blood vessel development. Unfortunately, many of these cancer treatments fail to completely stop angiogenesis in the tumor microenvironment (TME). Since these therapies focus on the biochemical activation of VEGFR-2 via VEGF ligand binding, we …

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The Shifting Nature Of Empire: Vandalia And Other Plans For New Colonies West Of The Allegheny Mountains Before The American Revolution, Michael Davis Jan 2022

The Shifting Nature Of Empire: Vandalia And Other Plans For New Colonies West Of The Allegheny Mountains Before The American Revolution, Michael Davis

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North American westward expansion following the end of the Seven Years’ War is a subject that has been dealt with by many historians from both sides of the Atlantic. The American push west of the Allegheny Mountains facilitated political divisions and divergent visions that would advance the push for independence from the British Empire and contribute to the creation of a new authority and a new kind of empire. This paper focuses on one aspect of this significant area of late-colonial and early republican American history. New western colonial schemes emerged from the ashes of the global war with France …

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Ecology Of The Diamondback Terrapin (Malaclemys Terrapin Pileata) In Alabama: Applications Of New Technologies, Forrest William Collins Jan 2022

Ecology Of The Diamondback Terrapin (Malaclemys Terrapin Pileata) In Alabama: Applications Of New Technologies, Forrest William Collins

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The Diamondback Terrapin, Malaclemys terrapin pileata, inhabits saltmarshes in the Northern Gulf of Mexico including along the coast of Alabama. Due to a variety of factors, this species has declined drastically in Alabama, and it is currently designated as a “species of highest conservation concern”. Understanding the ecology of this species is a prerequisite to the recovery of this population. The current thesis addresses the reproductive and foraging ecology of the Diamondback Terrapin in Alabama. This thesis combines the use of classic ecological methodologies with modern technologies. Between April 2019 to July 2022, wild nesting females were caught at a …

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The Ethos Of Donald Trump: Trump's Lack Of Presidential Decorum From 2016 Forward And Its Impact On American Politics, Nora M. Krall Jan 2022

The Ethos Of Donald Trump: Trump's Lack Of Presidential Decorum From 2016 Forward And Its Impact On American Politics, Nora M. Krall

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In American politics, the concept of presidential decorum is upheld through the complexity of political and presidential rhetoric. When Donald Trump became president, he sought to break what standard decorum was in order to justify his desires as president. This breaking of decorum is complex in nature and is paired with mediatization, demagoguery, populism and collectivism, all of which are rhetorical strategies that challenge the norms within American democracy and in turn, have created a shift in what is considered presidential. Donald Trump seeks to utilize his personal ethos alongside these rhetorical methods to infiltrate multiple subsets of society, thus …

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Klf2 Regulation Of Glycocalyx Expression, Barrier Function, And Thromboinflammation In Human Lung Microvascular Endothelial Cells, Cambria O'Grady Jan 2022

Klf2 Regulation Of Glycocalyx Expression, Barrier Function, And Thromboinflammation In Human Lung Microvascular Endothelial Cells, Cambria O'Grady

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KLF2 is an important transcription factor for maintaining vascular homeostasis. Its expression in endothelial cells is triggered by shear stress. The endothelial glycocalyx also plays a role in regulating vascular function, and prior work has shown that glycocalyx expression is affected by shear stress as well. However, the direct link between KLF2 and mechanisms that regulate glycocalyx synthesis has not been established. In the present study, we used human lung microvascular endothelial cells (HLMVECs) to observe changes in glycocalyx expression, barrier function, and thromboinflammation caused by KLF2 overexpression. Lentiviral transduction was the method used for KLF2 overexpression, resulting in a …

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Study Of Microrna-23a Cluster In Bone Formation, Revati Suryawanshi Jan 2022

Study Of Microrna-23a Cluster In Bone Formation, Revati Suryawanshi

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The differentiation of mesenchymal stem cells to pre-osteoblasts, lies upon various transcription factors and physiological signaling, but is also governed by the micro-RNA-23a cluster. The miR-23a cluster has miR-23a, miR-27a and miR-24-2 transcribed from a single promoter as a sole RNA primary transcript. Its effects have been observed in embryonic stem cells, mesenchymal stem cells (MSCs), and in cancer (1-2). It regulates the lineage commitment of MSCs. (3). With respect to bone formation, miR-23a cluster is involved MSCs commitment to and osteoblast maturation (4). Here, through in vivo and in vitro experiments, we report that knock down of microRNA-23a cluster …

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Alterations In Synaptic Structure And Tau Phosphorylation In Alheimer's Disease, Courtney K. Walker Jan 2022

Alterations In Synaptic Structure And Tau Phosphorylation In Alheimer's Disease, Courtney K. Walker

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Alzheimer’s disease (AD) is the most common cause of dementia in individuals over the age of 65. Of the two hallmark pathologies of AD, tau neurofibrillary tangles (NFTs) correlate more strongly with cognitive decline than do Aβ plaques. NFTs form in the entorhinal cortex (EC) and appear in anatomically connected regions over time as disease progresses. This tau spreading may occur via synaptic connections. Most excitatory synapses occur on dendritic spines, which house the postsynaptic machinery. Spines are actin-rich, plastic structures that change their size and shape in response to synaptic activity in a process that is dependent on actin …

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Renal Lactate Dehydrogenase A: Underlying Mechanisms And Inflammatory Roles In Acute Kidney Injury, Gunars Osis Jan 2022

Renal Lactate Dehydrogenase A: Underlying Mechanisms And Inflammatory Roles In Acute Kidney Injury, Gunars Osis

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Kidneys are physiologically vital organs responsible for blood homeostasis preservation through fluid balance maintenance, blood pressure regulation, hormone production, and toxic compound removal. Acute kidney injury (AKI) is a global condition affecting more than 13 million people yearly, and is characterized by a rapid decline in renal filtration capacity, consequent rise in serum creatinine and nitrogenous waste levels, and is associated with an elevated risk of morbidity in the form of progressive chronic kidney disease, kidney failure, and mortality. AKI-induced renal epithelial cell death forces surviving tubular cells to undergo de-differentiation, rapid proliferation to replace lost cells, and re-differentiation to …

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Study Of The Effects Of Contusion Spinal Cord Injury And Optogenetic Stimulation On Lower Urinary Tract Function, Salvador A. Lopez Jan 2022

Study Of The Effects Of Contusion Spinal Cord Injury And Optogenetic Stimulation On Lower Urinary Tract Function, Salvador A. Lopez

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Lower urinary tract (LUT) dysfunction is a detrimental ailment that negatively affects a person’s independence, health, and overall quality of life. More specifically, LUT dysfunction as a result of spinal cord injury (SCI) is seen in more than 17,000 cases per year and of those cases, <20% are discharged from care with normal micturition1. Initially, after SCI, there is an acute period of spinal shock when the urinary bladder is flaccid and underactive, while the external urethral sphincter (EUS) that constricts the bladder outlet quickly becomes tonically active. In days to weeks after injury, spinallymediated, reflex bladder contractions re-emerge2-4. Numerous studies have examined aspects of LUT function using various models of SCI, primarily utilizing complete transection injuries. This set of studies first examined the effect of moderate to severe midthoracic contusion SCI on LUT function by examining cystometrogram (CMG) and EUS recordings, bladder/spinal cord morphology, sensory innervation of bladder tissue, and spinal neuronal activation in female mice. This model of SCI produced significant changes in normal bladder function as well as altered bladder morphology, including a robust loss of bladder afferent nerve fibers necessary for micturition. Inhibition of histone deacetylase 6 (HDAC6) has been shown to prevent the loss of sensory nerve fibers in mouse hind paw tissue5, thus HDAC6 inhibition was examined as a possible strategy to prevent the observed loss of sensory nerve fibers in bladder tissue post-SCI. iv Mice were treated using intraperitoneal injections of inhibiting compounds ACY-1083 (10 mg/kg) or Tubacin (5 mg/kg). Treatment resulted in significant improvements in CMG measures and sensory innervation of the bladder wall. Finally, optogenetic stimulation was examined using an adenoassociated virus containing cre-recombinase for cre-dependent expression of channelrhodopsin (ChR2) in both spinal intact and SCI mice. The ability to spare afferent axons in bladder tissue post-SCI through HDAC6 inhibition allowed ChR2 expression in sensory nerve fibers. Direct photostimulation of the bladder using various parameters of duration (1, 2, 5, 10 sec continuous stimulation) and power (0.1mW/mm2, 0.95mW/mm2, 6.50mW/mm2) resulted in the ability to control bladder contractions in both spinal intact (SI) and SCI animals, allowing for on-demand voiding post-injury.

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Hedgehog Signaling Rewires M2 Macrophage And Regulatory T Cell Metabolism Within The Tumor Microenvironment Of Breast Cancer, Dominique C. Hinshaw Jan 2022

Hedgehog Signaling Rewires M2 Macrophage And Regulatory T Cell Metabolism Within The Tumor Microenvironment Of Breast Cancer, Dominique C. Hinshaw

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Current treatments for breast cancer offer little relief to patients with metastatic disease. A contributory factor to tumor growth and metastasis is aberrant up-regulation of developmental signaling pathways such as the Hedgehog (Hh) signaling pathway. This pathway is aberrantly activated in breast cancer and contributes to tumor progression and metastasis. The success of these events is highly influenced by the surrounding immune microenvironment. Macrophages exist along a spectrum of M1 (tumor-eradicating) to M2 (tumor-promoting), while regulatory T cells (Tregs) are an immunosuppressive cell type. The predominant functions of M2 macrophages and Tregs include dampening the immune response and promoting wound …

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Pkd-1 Signaling Inthe Regulation Of Cancer Stem Cell-Like Features And Cancer Cell Interactions With Endothelial Cells In Breast Cancer And Pancreatic Neuroendocrine Tumor, Yichen Hailey Guo Jan 2022

Pkd-1 Signaling Inthe Regulation Of Cancer Stem Cell-Like Features And Cancer Cell Interactions With Endothelial Cells In Breast Cancer And Pancreatic Neuroendocrine Tumor, Yichen Hailey Guo

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Cancer stem cells (CSCs) are a subpopulation cancer cells that play critical roles in tumor progression, recurrence, metastasis, and drug resistance. CSCs are characterized by self-renewal and plasticity. Protein kinase D-1 (PKD-1) signaling regulates CSC/stemness features in both breast cancers and pancreatic neuroendocrine tumors. In PNETs, PKD-1 signaling regulates not only stemness properties of cancer, but also epithelial-mesenchymal transition (EMT). PNETs are typically well vascularized and heterogeneous. Everolimus (an mTOR inhibitor and the 2nd generation derivative of rapamycin) has been approved as a targeted chemotherapy for PNET patients. Unfortunately, nearly all patients will progress on treatment due to drug resistance …

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The Role Of Protein Translation And Degradation In Aging And Alzheimer Disease Pathogenesis, Harper S. Kim Jan 2022

The Role Of Protein Translation And Degradation In Aging And Alzheimer Disease Pathogenesis, Harper S. Kim

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Protein translation (PT) is an essential cellular process playing crucial roles in growth and development. PT precipitously declines with age in multiple animal species, including humans. It has been implicitly assumed that elevated PT at young ages is beneficial to health while PT ends up dropping as a passive byproduct of aging. However, whether this holds true and how dynamic fluctuations in PT over time impact aging remain unknown. In Drosophila, we show that a transient PT spike in early-adulthood drives aging by triggering dysfunction in protein homeostasis (proteostasis) at old ages. We propose the early-adulthood spike in PT to …

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Determining The Impact Of Immune Dysregulation On Cd4 T Cell Responses To Hiv-1 And Sars-Cov-2, Jacob K. Files Jan 2022

Determining The Impact Of Immune Dysregulation On Cd4 T Cell Responses To Hiv-1 And Sars-Cov-2, Jacob K. Files

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CD4+ T cells, often referred to as helper T cells, play a crucial role in the formation of antiviral immune responses following infection and vaccination. However, this can be disrupted by various forms of immune dysregulation. Many groups have described how HIV-1 adaptation and immune escape can lead to dysregulated HIV-specific immune responses. Our lab has previously shown that predicted HLA-II associated HIV-1 adaptation leads to dysregulated, poorly immunogenic CD4+ T cell responses in HIV-1 infection. Here, we focus on the impact of this HLA-II associated viral adaptation in the setting of HIV-1 vaccination. We show that HLA-II associated, vaccine-matched …

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Driving Anger And Aggression In Persons With And Without Adhd, Maria T. Lechtreck Jan 2022

Driving Anger And Aggression In Persons With And Without Adhd, Maria T. Lechtreck

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Driving a motor vehicle is both a privilege and one of the primary activities of daily living for most persons in the U.S. and many persons abroad; however, motor vehicle collisions (MVCs) bring great costs both to individuals and society. Driver behavior is the critical factor in an estimated 94% of MVCs and aggressive driving is the cause of two-thirds of U.S. traffic fatalities. Certain populations are at an increased risk for MVCs including persons who are young (ages 15-24), persons who have developmental disabilities such as Attention-Deficit/Hyperactivity Disorder (ADHD), and persons who have a high propensity for driving-related anger. …

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Biomanufacturing Of Micro-Myocardial Tissue Through Suspension Differentiation With Improved Yields, Purity, And Quality, Asher M. Kahn-Krell Jan 2022

Biomanufacturing Of Micro-Myocardial Tissue Through Suspension Differentiation With Improved Yields, Purity, And Quality, Asher M. Kahn-Krell

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Despite major advances in revascularization and drug therapy for post-myocardial infarction (MI) heart failure (HF), heart transplantation remains the only curative therapy to prevent progressive and debilitating disease. Researchers have long sought a replenishable and expandable source of cardiomyocytes (CMs), the primary functional cell in the heart muscle, for a broad array of applications related to the treatment of HF ranging from direct implantation to high throughput drug testing. The lack of cell cycle activity and cell division in adult CMs prevented the development of an expandable primary cell line. However, with the discovery of high efficiency stem cell differentiation …

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Temperature-Dependent Sex Determination (Tsd): Implications For The Biology And Conservation Of The Kemp's Ridley Sea Turtle (Lepidochelys Kempii), Katherine Presz Jan 2022

Temperature-Dependent Sex Determination (Tsd): Implications For The Biology And Conservation Of The Kemp's Ridley Sea Turtle (Lepidochelys Kempii), Katherine Presz

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The Kemp’s ridley sea turtle (Lepidochelys kempii) has temperature-dependent sex determination (TSD) where the incubation temperature of the egg determines the sex of the hatchling. This has significant implications for the ecology, evolution, and conservation of this species because it can affect sex ratios. The studies presented in this thesis address hatchling sex ratios produced in Kemp’s ridley conservation programs using both natural as well as manipulated incubation regimes. First, a histology-based study was utilized to investigate sex ratios produced at the Padre Island National Seashore from 2002-2019. The results indicate that a female bias has been produced each year …

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Early Life Stress And Barrier Dysfunction Of The Blood-Brain Barrier, Margaret Ellen Lloyd Jan 2022

Early Life Stress And Barrier Dysfunction Of The Blood-Brain Barrier, Margaret Ellen Lloyd

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Early Life Stress (ELS) refers to any process or event of chronic and/or sever stress that occurs early in an individual’s development; this can be spurred by environmental or behavioral cues and helps predict inflammation later1 in life. ELS is associated with increased risk of cardiovascular disease (CVD) and other chronic conditions like depression. However, many of the physiological processes that lead to increased risk of chronic illness later in life have yet to be established or examined. The ELS mouse model is used to examine the unknown mechanistic links between childhood stress and risk for chronic disease in adulthood. …

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An Evaluation Of The In Vitro Antibacterial, Biocompatibility, And Mineralization Properties Of Six Calcium Silicate-Based Pulp Capping Materials, Taimy Cruz Hondares Jan 2022

An Evaluation Of The In Vitro Antibacterial, Biocompatibility, And Mineralization Properties Of Six Calcium Silicate-Based Pulp Capping Materials, Taimy Cruz Hondares

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Purpose: The purpose of this study was to evaluate the antibacterial activity, biocompatibility, and mineralization-inducing potential of calcium silicate-based pulp capping materials. Methods: Six contemporary calcium silicate-based pulp capping materials were compared in this study, including ProRoot MTA, MTA Angelus, Biodentine, EndoSequence, NeoMTA 2 and NeoPutty. The antibacterial effects of these materials against Streptococcus mutans UA159 and Enterococcus faecalis ATCC 29212 were determined by the agar-diffusion assay and the direct culture test. The biocompatibility and mineralization-inducing potential of these materials in preodontoblastic 17IIA11 cells were compared by the MTT assay and by evaluating alkaline phosphatase activity and calcium deposits, respectively. …

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Dear Former Phenom, Meredith Beretta Jan 2022

Dear Former Phenom, Meredith Beretta

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Dear Former Phenom is a collection of essays and poems covering my life as a female athlete in America, beginning when I was a small child and continuing to my retirement after my senior year as a collegiate student-athlete. As it stands, the collection is incomplete. This current version contains the core memories and the foundation of my discussion. This collection tells the story of my failure to reach my full potential as an athlete. It is the story of me constantly achieving higher and higher achievements, awards, accolades, and praise until I didn’t anymore. Until there was no one …

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We'll Eat You Up, We Love You So: On The Changes Of The Children's Horror Genre From The 17th Century Onward, Camrie Ann Latham Jan 2022

We'll Eat You Up, We Love You So: On The Changes Of The Children's Horror Genre From The 17th Century Onward, Camrie Ann Latham

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Research into the children’s horror genre is, currently, quite limited in that it is often only tangentially related to the history and qualities of the genre itself. This research is typically focused on horror at large, horror films for children, or children in horror. This thesis seeks to analyze the history of the genre and categorize the shifting purposes and intentions that, in turn, reflect larger social fears. It defines these purposes as moving from that of control, to entertainment, to empowerment, with transitionary periods in between. The thesis is also formatted chronologically, beginning in the late 1600s and continuing …

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Insulation And Paper, Mary Elizabeth Skinner Jan 2022

Insulation And Paper, Mary Elizabeth Skinner

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Insulation and Paper reflects on my childhood and teenage years as a dreamy, adventure-seeking teenager who faced the harsh realities of living through an EF-4 tornado. This piece explores the ups and downs of being homeschooled, the scars of unprocessed trauma, complex family bonds, and growing up being Catholic and homeschooled. The story starts on April 26, 2011, the night before a deadly tornado outbreak, where I was writing on a story titled, Atallas. The first few chapters demonstrate how obsessed I was with fantasy, dance, storms, and adventure, being stuck at home with only a few friends. As the …

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The Potential Roles Of Broccoli Sprouts (Bsp) And Green Tea Polyphenols (Gtps) In Prevention Of Mammary Cancer, Itika Arora Jan 2022

The Potential Roles Of Broccoli Sprouts (Bsp) And Green Tea Polyphenols (Gtps) In Prevention Of Mammary Cancer, Itika Arora

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Cancer is one of the leading causes of death in the United States. Based on the American Cancer Society statistics, in 2021 1,806,590 new cancer cases and 605,520 cancer deaths are projected to occur in the United States. Amongst all, breast cancer (BC) is one of the most prevalent cancers that occurs in women. Various lifestyle factors such as alcohol intake, smoking, an unhealthy diet and physical inactivity may result in increased rates of BC risks (cancer-transition) by inducing mutations in DNA. Numerous epidemiological studies indicate that a diet rich in green tea polyphenols (GTPs), and/or cruciferous vegetables such as …

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The Role Of Nitric Oxide And Cyclic Guanosine Monophosphate Signaling In Arteriovenous Fistula Maturation, Maheshika S. Somarathna Jan 2022

The Role Of Nitric Oxide And Cyclic Guanosine Monophosphate Signaling In Arteriovenous Fistula Maturation, Maheshika S. Somarathna

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Vascular access is the single most important component of the hemodialysis procedure and the arteriovenous fistula (AVF) is the most preferred type. However, 60% of AVFs created fail to mature successfully for dialysis use (AVF maturation failure). AVF maturation failure is primarily the result of 1) intimal hyperplasia formation (IH) and 2) poor vascular outward remodeling. Currently, a major unmet clinical need in the field is the lack of effective therapies to treat/prevent AVF maturation failure due to the poor understanding of molecular mechanisms. This proposal is designed to: 1) elucidate the pathologic significance of nitric oxide (NO) and cyclic …

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