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Change In Conduction Velocity Due To 2d Fiber Curvature In Cultured Neonatal Rat Ventricular Myocytes, Elliot Blake Bourgeois Jan 2006

Change In Conduction Velocity Due To 2d Fiber Curvature In Cultured Neonatal Rat Ventricular Myocytes, Elliot Blake Bourgeois

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Continuum modeling of two-dimensional curved fiber fields has suggested that fiber curvature modulates conduction velocity (CV) in the myocardium. To verify the existence of this effect in living tissue, we measured CV in macroscopically anisotropic monolayers of cultured neonatal rat ventricular myocytes with controlled fiber curvature. A novel growthdirecting substrate was used to produce fiber fields with significant curvature (78°/cm to 333°/cm). Anisotropy ratios (longitudinal CV / transverse CV) measured in cultures grown using this method (n=32) were 2.3±0.3, which is similar to the anisotropy exhibited by human ventricular myocardium. Propagating wavefronts were initiated transverse to fiber orientation in two …

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Micro-Computed Tomographic Analysis Of Bone Healing Subsequent To Graft Placement, Preeti M. Chopra Jan 2006

Micro-Computed Tomographic Analysis Of Bone Healing Subsequent To Graft Placement, Preeti M. Chopra

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A MicroCT analysis of bone healing subsequent to graft (tri calcium phosphate/TCP) placement in the maxillary sinus prior to dental endosteal implant placement was the objective of the current study. Ten trephined rod shaped human bone cores were obtained three months after the placement of particulate graft material and the samples were stored immediately in 10% neutral buffered formalin. Using a Microcomputed tomography, the samples were evaluated at resolutions of 6 and 20μm. The thresholds for bone and graft material were determined using visual image, intensity (grey level) and histogram analyses. The graft and bone threshold was 235 greylevel and …

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Speciation Of Alkali Metals In Biomass Combustion And Gasification, Pavankumar Bajrang Sonwane Jan 2006

Speciation Of Alkali Metals In Biomass Combustion And Gasification, Pavankumar Bajrang Sonwane

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Electricity from biomass and biomass–derived fuels has become an attractive and viable alternative energy source. Alkali metals, mainly sodium and potassium, together with other ash forming inorganic components in biomass, increase fouling, slagging, and high temperature corrosion of heat transfer surfaces in boilers thus reduces efficiency during biomass combustion. Future biomass-to-electricity facilities will benefit from increased efficiencies, by incorporating integrated gasification combined cycle systems that use biomass syngas directly in gas turbine. These systems will have even lower tolerances for alkali vapor release, because accelerated erosion and corrosion of turbine blades results in shorter turbine life. One solution to the …

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Gas Phase Dynamics Of Laser-Generated Nanoparticle Populations And Its Application To Nanomaterials Fabrication, Mevlut Bulut Jan 2006

Gas Phase Dynamics Of Laser-Generated Nanoparticle Populations And Its Application To Nanomaterials Fabrication, Mevlut Bulut

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Naturally occurring materials often derive their outstanding properties from optimal anisotropic arrangements of nanoscale constituents. This requires a hierarchical organization of matter over several length scales, which is difficult to achieve in artificial materials made by conventional physical and chemical methods. This dissertation explores the combination of laser and aerosol processes as a novel approach to make thin film materials with a level of microscopic organization similar to that found in nature. Through a systematic investigation of the behavior of the gas-phase dynamics of nanoparticles generated by laser ablation of solid target materials in background gases and a study of …

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Modulation Of Cell Signaling By Tomoregulins In Embryogenesis And Cancer, Paul William Harms Jan 2006

Modulation Of Cell Signaling By Tomoregulins In Embryogenesis And Cancer, Paul William Harms

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Growth factor signals often regulate similar cellular processes both during embryogenesis and in adult homeostasis. Stringent control of these signals ensures proper embryonic development and correct cell physiology in mature individuals. Recently, a family of two members of Tomoregulin (or transmembrane protein with epidermal growth factor-like and two follistatin domains [TMEFF]) was found to interact with transforming growth factor-β (TGF-β) and ErbB signaling pathways, both of which are implicated in development and in cancer biology in the adult. The function as well as the mechanisms of TMEFFs in modulating these two signals has not been elucidated in detail. In this …

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Lawrence County's Dropouts' Perceptions Of Why They Chose To Become Early Leavers., Jewell C. Satchel Jan 2006

Lawrence County's Dropouts' Perceptions Of Why They Chose To Become Early Leavers., Jewell C. Satchel

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No abstract provided.

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The Effect Of Environmentally-Related Cardiovascular Disease Risk Factors On Mitochondrial Damage And Atherogenesis., Zhen Yang Jan 2006

The Effect Of Environmentally-Related Cardiovascular Disease Risk Factors On Mitochondrial Damage And Atherogenesis., Zhen Yang

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No abstract provided.

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A Survey Assessment Of Veterinarians To Determine The Level Of Preparedness For An Infectious Disease Outbreak, Tamara Crutchley Bushell Jan 2006

A Survey Assessment Of Veterinarians To Determine The Level Of Preparedness For An Infectious Disease Outbreak, Tamara Crutchley Bushell

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Safeguarding animal health is of paramount importance to the US economy, public health and food safety. One of the most important causes of contamination in food products and of food-borne disease in humans is microorganisms that reside in the intestines of animals, such as Salmonella species and Escherichia coli O157:H7. A fundamental knowledge of the epidemiology of diseases, including an understanding of the agents and hosts, is a critical component of early (front-line) detection and prevention of contamination by microorganisms. Front-line detection is provided by animal handlers and personnel working with animals on a day-to-day basis, such as veterinarians. Currently …

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Increased Hexosamine Biosynthesis And Protein O-Glcnac Protect Isolated Rat Heart From Ischemia/Reperfusion Injury, Jia Liu Jan 2006

Increased Hexosamine Biosynthesis And Protein O-Glcnac Protect Isolated Rat Heart From Ischemia/Reperfusion Injury, Jia Liu

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Increased levels of protein-associated O-linked N-acetylglucosamine (O-GlcNAc) have been correlated with increased tolerance to stress. Therefore the goal of this study was to determine whether enhanced flux through the hexosamine biosynthesis pathway (HBP), which leads to elevated levels of O-GlcNAc, increased the tolerance of the heart to ischemia and reperfusion (I/R). Hearts from male rats were isolated and perfused with Krebs-Henseliet buffer containing 5mM glucose, and global, no-flow ischemia was induced for 20min followed by 60 min reperfusion. 20 min pre-treatment with 10 mM glucosamine, which enters the HBP directly, significantly improved functional recovery and decreased cardiac Troponin I release …

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Regulation Of Ss-Catenin By Gli1 In Epithelial Transformation, Xingnan Li Jan 2006

Regulation Of Ss-Catenin By Gli1 In Epithelial Transformation, Xingnan Li

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Gli family members-mediated continuous Hedgehog (Hh) pathway activity plays a role in the growth of a number of human cancers, including the common malignancy of skin, basal cell carcinoma (BCC), and other highly aggressive tumor types. However, the mechanism by which Gli proteins act to promote the outgrowth of cancer in response to stimulation of Hh signaling is poorly understood. Identified as zinc finger transcriptional factors, the Gli family of proteins has been shown to be involved in multiple cellular processes through activating its target genes. Therefore, to study the function of Gli target genes is important for our understanding …

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Klf4 Regulates Notch1 Expression And Signaling During Epithelial Transformation, Zhaoli Liu Jan 2006

Klf4 Regulates Notch1 Expression And Signaling During Epithelial Transformation, Zhaoli Liu

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Notch1 and KLF4 function in the specification of epithelial cell fates, and each can act as a context-dependent oncogene or tumor suppressor. We report that KLF4 directly regulates transcription of Notch1 and that cleavage of full-length Notch1 to the active intracellular form, N1IC, is necessary for transformation by KLF4. Paradoxically, KLF4 suppresses canonical Notch1-CSL signaling by up-regulating Hairless, an antagonist of this pathway. Dominant-negative inhibitors of the canonical Notch1 signaling pathway do not block transformation of epithelial cells by KLF4, while they greatly reduce the efficiency of transformation by N1IC. Thus, N1IC can transform cells by two distinct mechanisms: the …

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Kiss1 Metastasis Suppressor Secretion Is Required For Metastasis Suppression, Kevin T. Nash Jan 2006

Kiss1 Metastasis Suppressor Secretion Is Required For Metastasis Suppression, Kevin T. Nash

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Failure to reduce the number of cancer deaths over the last 50 years is due to the inability to selectively target metastatic disease. Recently, the KISS1 metastasis suppressor has emerged as a promising molecular agent for the management of metastatic disease. Although KISS1 has been implicated in the regulation of the metastatic phenotype in human cancers and in in vivo mouse models, little is known about its mechanism. Recent evidence suggests that KISS1 is a neuropeptide that is processed and secreted to interact with its cognate receptor GPR54 in the hypothalamus to trigger puberty and maintain the reproductive state. However, …

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Intestinal Peptides And Ethnic Differences In Insulin Secretion, Paul B. Higgins Jan 2006

Intestinal Peptides And Ethnic Differences In Insulin Secretion, Paul B. Higgins

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African Americans (AA) exhibit greater insulin responses following either an oral or intravenous glucose challenge relative to their European American (EA) counterparts. The etiology of this difference is not fully understood nor has it been confirmed with a more physiologically relevant mixed meal. Insulin secretion is regulated by a variety of factors. Significant among these are the enteric peptides glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). The role of the incretin system in the ethnic differences in post challenge insulinemia has received little attention. Hence, the purpose of the study was two-fold. First, determine whether AA have higher fasting …

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Surface Reconstruction Using Gamma Shapes, Ying Sun Jan 2006

Surface Reconstruction Using Gamma Shapes, Ying Sun

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Surface reconstruction from a set of sample points is important in many applications, including computer graphics, reverse engineering, computer vision and medical imaging. In this dissertation, several surface reconstruction techniques are investigated and the Alpha Shapes method is studied in detail. A new method, called Gamma Shapes, is introduced and implemented for reconstructing surfaces from a set of unorganized sample points. The Alpha Shapes method requires that the data point set be uniformly sampled in order to reconstruct an acceptable surface. Gamma Shapes method is an extension of the Alpha Shapes method with the advantage that the Gamma Shapes method …

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Molecular Regulation Of Neural Stem Cell Apoptosis., Rizwan S. Akhtar Jan 2006

Molecular Regulation Of Neural Stem Cell Apoptosis., Rizwan S. Akhtar

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No abstract provided.

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Behavioral And Neurochemical Consequences Of A History Of Human -Like Dieting., Paula C. Chandler-Laney Jan 2006

Behavioral And Neurochemical Consequences Of A History Of Human -Like Dieting., Paula C. Chandler-Laney

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No abstract provided.

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Capsid -Membrane Interactions In Mason -Pfizer Monkey Virus Budding., Elizabeth Heather Stansell Jan 2006

Capsid -Membrane Interactions In Mason -Pfizer Monkey Virus Budding., Elizabeth Heather Stansell

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No abstract provided.

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Identification And Characterization Of The O-Glcnaczyme: A Multienzyme Complex Regulating O-Glcnac Modification., Thomas R. Whisenhunt Jan 2006

Identification And Characterization Of The O-Glcnaczyme: A Multienzyme Complex Regulating O-Glcnac Modification., Thomas R. Whisenhunt

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No abstract provided.

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O-Glcnac In Development., Damon Brian Bowe Jan 2006

O-Glcnac In Development., Damon Brian Bowe

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No abstract provided.

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Determination Of Dietary Protein, Carbohydrate, And Lipid Requirements For The Sea Urchin Lytechinus Variegatus Fed Semi-Purified Feeds., Hugh S. Hammer Jan 2006

Determination Of Dietary Protein, Carbohydrate, And Lipid Requirements For The Sea Urchin Lytechinus Variegatus Fed Semi-Purified Feeds., Hugh S. Hammer

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No abstract provided.

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Huntington's Disease Cag Repeat Instability And Ubiquitin Proteasome System Alterations., Jesse M. Hunter Jan 2006

Huntington's Disease Cag Repeat Instability And Ubiquitin Proteasome System Alterations., Jesse M. Hunter

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No abstract provided.

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Contributions Of The Left And Right Hemisphere To Ratio Scaling., Tracy S. Kretzmer Jan 2006

Contributions Of The Left And Right Hemisphere To Ratio Scaling., Tracy S. Kretzmer

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No abstract provided.

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Recognition Memory Of The Human Face: A Magnetoencephalography Study., Dongwook Lee Jan 2006

Recognition Memory Of The Human Face: A Magnetoencephalography Study., Dongwook Lee

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No abstract provided.

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Muscarinic Long -Term Depression At Ca3 -Ca1 Synapses: Interactions With Electrically Induced Synaptic Plasticity And Intracellular Signaling., Mary Eve Mccutchen Jan 2006

Muscarinic Long -Term Depression At Ca3 -Ca1 Synapses: Interactions With Electrically Induced Synaptic Plasticity And Intracellular Signaling., Mary Eve Mccutchen

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No abstract provided.

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Brms1 Suppresses Breast Cancer Metastasis To Multiple Organs., Pushkar A. Phadke Jan 2006

Brms1 Suppresses Breast Cancer Metastasis To Multiple Organs., Pushkar A. Phadke

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No abstract provided.

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Immunogenetic And Cytokine Factors On Genital Chlamydia Trachomatis Infection., Chengbin Wang Jan 2006

Immunogenetic And Cytokine Factors On Genital Chlamydia Trachomatis Infection., Chengbin Wang

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No abstract provided.

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Age Differentials In Involuntary Migration -Induced Distress., Juan Xi Jan 2006

Age Differentials In Involuntary Migration -Induced Distress., Juan Xi

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No abstract provided.

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A Geographic Study Of Childhood Cancers Near Hazardous Waste Sites In Florida., Gregory D. Kearney Jan 2006

A Geographic Study Of Childhood Cancers Near Hazardous Waste Sites In Florida., Gregory D. Kearney

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No abstract provided.

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Shaping Of Local Network Activity By Neuromodulators In Rat Neocortex., Susanta Bandyopadhyay Jan 2006

Shaping Of Local Network Activity By Neuromodulators In Rat Neocortex., Susanta Bandyopadhyay

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No abstract provided.

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Conserved Locus Control Region Sequences Controlling Beta-Globin Gene Expression In Mice., Andrea A. Svendsen Jan 2006

Conserved Locus Control Region Sequences Controlling Beta-Globin Gene Expression In Mice., Andrea A. Svendsen

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No abstract provided.

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