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A Rhetoric Of Resolution: The Limits Of Competition, Michael Schandorf Jan 2008

A Rhetoric Of Resolution: The Limits Of Competition, Michael Schandorf

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The idea of competition underlies most all Western cultural practices making conflict inevitable, but understanding the world in terms of constant, perpetual competition limits the development of lasting, adaptive, and constructive solutions to human problems and conflicts. While competition serves the vital functions of quality control and the identification of best practices, the function of “Competition” as a god term betrays a misunderstanding of both the value and process of competition as an instrument, and demonstrates how human conceptualization, mediated by language, can direct the development and acquisition of knowledge into narrow channels and exclude ways of understanding that are …

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Traffic Responsive Signal Systems To Address Rain-Related Congestion, Suman Reddy Surabhi Jan 2008

Traffic Responsive Signal Systems To Address Rain-Related Congestion, Suman Reddy Surabhi

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Rainy conditions typically have an impact on the behavior of drivers and in turn can affect traffic flow characteristics in transportation networks. As a result, signal timing plans developed for dry conditions may be unsuitable or sub-optimal during periods of rain, and changes in such plans may be desirable to account for changes in environmental conditions. Current technology in the field of traffic signal control and communications make it possible to change the signal controller settings remotely, a capability that offers opportunities for signal timing adjustments during rain conditions. This study explores the feasibility and benefits of implementing alternative signal-timing …

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Developmentally Appropriate Practice And No Child Left Behind: A Phenomenological Study Of Teachers' Experiences, Linda Marie Hogue Jan 2008

Developmentally Appropriate Practice And No Child Left Behind: A Phenomenological Study Of Teachers' Experiences, Linda Marie Hogue

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The authorization of The Elementary and Secondary Act—No Child Left Behind (NCLB) Act of 2001 provided new federal guidelines for accountability in the United States. As a result, schools are required to provide statistical data through standardized test scores to measure adequate yearly progress benchmarks set by each state. The agenda of the federal government was to force school equity for all children. Since the inception of NCLB, teachers have begun the struggle of meeting the demands of federal, state, and local guidelines that impose harsh penalties if benchmarks are not attained by their students. The National Association for the …

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Techniques For Context-Free Grammar Induction And Applications, Faizan Javed Jan 2008

Techniques For Context-Free Grammar Induction And Applications, Faizan Javed

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Grammar Inference is the process of learning a grammar from examples, either positive (i.e., the grammar generates the string) and/or negative (i.e., the grammar does not generate the string). Although grammar inference has been successfully applied to many diverse domains such as speech recognition and robotics, its application to software engineering has been limited. This research investigates the applicability of grammar inference to software engineering and programming language development challenge problems, where grammar inference offers an innovative solution to the problem, while remaining tractable and within the scope of that problem. Specifically, the following challenges are addressed in this research: …

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Air Pollution And Preterm Births In Atlanta, Georgia, Corey Masuca Jan 2008

Air Pollution And Preterm Births In Atlanta, Georgia, Corey Masuca

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Exposure to ambient outdoor air pollution exposure is one of the many extraneous factors associated with preterm births. Many epidemiological studies involving preterm births and ambient air pollution have repeatedly indicated positive associations. However, for many such studies, results may be statistically significant but weakly associated or inconclusive. Such results may be primarily attributable to the fact that most studies include only single or multiple criteria air pollutants but not the total air pollution mixture of criteria air pollutants and air toxic pollutants (e.g., PAHs) to which people are actually exposed. This study assessed associations between pollutant classes, including criteria …

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Growth Hormone Signaling And Action In Osteoblasts, Douglas J. Digirolamo Jan 2008

Growth Hormone Signaling And Action In Osteoblasts, Douglas J. Digirolamo

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Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) exert profound growth promoting actions during pre- and post-natal skeletal development. GH and IGF- 1 appear to cause these anabolic actions by influencing a variety of effects on osteoblast proliferation, differentiation, and survival. However, because GH stimulates the production of IGF-1 from the liver and other GH-responsive peripheral tissues, including bone, the individual contributions of these two molecules to anabolic responses in bone remains poorly defined. In this dissertation research, I sought to distinguish the direct and indirect (IGF-1 dependent) GH actions on osteoblasts. In the first section of this thesis, I …

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Effects Of Aerobic Exercise On The Asthmatic Lung, Matthew M. Hewitt Jan 2008

Effects Of Aerobic Exercise On The Asthmatic Lung, Matthew M. Hewitt

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Asthma is identified by the clinical symptoms of wheezing, chest tightness, dyspnea and cough, and by the presence of airway hyperresponsiveness (AHR) to inhaled stimuli. We have reported previously that repeated bouts of moderate intensity aerobic exercise attenuate airway inflammatory responses in a mouse model of atopic asthma. Because the effects of exercise on physiological responses are dependent upon several variables, including total exercise duration, the hypothesis of the current work was that differing amounts of moderate intensity aerobic exercise exert dissimilar effects on AHR and airway inflammation. The aims to test this hypothesis included: 1) determine the effect of …

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Mapks Regulate Nuclear Import Of Human Papillomavirus Type 11 Replicative Helicase E1, Jei-Hwa Yu Jan 2008

Mapks Regulate Nuclear Import Of Human Papillomavirus Type 11 Replicative Helicase E1, Jei-Hwa Yu

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Papillomaviruses (PV) are prevalent pathogens that infect human or animal squamous epithelia. Its genome is a double strand circular DNA of approximately 7.9 kb. It contains origin of replication (ori) and encodes early viral proteins for viral DNA amplication, and late capsid proteins for packaging viron. The viral DNA replicates as extrachromosomal nuclear plasmid in the host cell. Infections by low risk virus, such as HPV-6 and -11, can result in benign papillomas, condylomata, and low grade squamous intraepithelial dysplasias (SIL), whereas infection by high risk virus, such as HPV-16 and -18, can progress to high grade SIL, carcinoma in …

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The Use Of Modeling Tools In The Analysis Of Functional Requirements, Gopi Kamadia Jan 2008

The Use Of Modeling Tools In The Analysis Of Functional Requirements, Gopi Kamadia

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The thesis offers an Object-Oriented analysis methodology to investigate the functional requirements of software systems with modeling technologies, such as Unified Modeling Language (UML) and Systems Modeling Language (SysML). The main focus of the analysis is to discover objects and describe them in the problem domain. The thesis also proposes a validation process for the requirements stage of the development life cycle with an Acclaro Design For Six Sigma (DFSS) approach. A software development experiment is carried out with a case study of a threedimensional graphics game. The game is first implemented without following any sound analysis process and then …

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Heroes, Jacob Melvin Jan 2008

Heroes, Jacob Melvin

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This thesis is a collection of five personal essays dealing with moral ambiguity. The essays fit into the genre of Creative Nonfiction. Moral ambiguity is a theme that can be traced throughout the history of literature. This thesis blends the elements of literature and nonfiction in order to craft essays around a theme of moral complexity.

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Electrospun Tri-Layer Micro/Nano-Fibrous Scaffold For Vascular Tissue Engineering, Xing Zhang Jan 2008

Electrospun Tri-Layer Micro/Nano-Fibrous Scaffold For Vascular Tissue Engineering, Xing Zhang

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No abstract provided.

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Awareness Of Functional Difficulties In Mild Cognitive Impairment: Relation To Cognitive Variables And Mood, Ozioma C. Okonkwo Jan 2008

Awareness Of Functional Difficulties In Mild Cognitive Impairment: Relation To Cognitive Variables And Mood, Ozioma C. Okonkwo

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No abstract provided.

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The Role Of Bhlh Gene Ash1 In The Developing Chick Eye, Weiming Mao Jan 2008

The Role Of Bhlh Gene Ash1 In The Developing Chick Eye, Weiming Mao

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No abstract provided.

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The Adaptive Immune System Of Sea Lamprey, Matthew N. Alder Jan 2008

The Adaptive Immune System Of Sea Lamprey, Matthew N. Alder

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No abstract provided.

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Factors Influencing The Use Of Outcome Measures In Physical Therapy Practice, Frances M. Wedge Jan 2008

Factors Influencing The Use Of Outcome Measures In Physical Therapy Practice, Frances M. Wedge

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No abstract provided.

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Hyposialylation Regulates Α4ss1 Integrin Binding To Vcam-1, Alencia V. Woodard-Grice Jan 2008

Hyposialylation Regulates Α4ss1 Integrin Binding To Vcam-1, Alencia V. Woodard-Grice

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No abstract provided.

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Microarray Data Analysis For Snp Effects And Inferring Alternative Splicing, Lang Chen Jan 2008

Microarray Data Analysis For Snp Effects And Inferring Alternative Splicing, Lang Chen

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No abstract provided.

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Effects Of Hexosamine Biosynthesis On An In Vitro Model Of Cardiacischemia, Voraratt Champattanachai Jan 2008

Effects Of Hexosamine Biosynthesis On An In Vitro Model Of Cardiacischemia, Voraratt Champattanachai

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Increased levels of protein O-linked-N-acetylglucosamine (O-GlcNAc) have been correlated with increased cell survival following stress. Therefore the goal of this study was to determine whether enhanced flux through the hexosamine biosynthesis pathway (HBP), which leads to elevated levels of O-GlcNAc, improved the tolerance of isolated neonatal rat ventricular myocytes (NRVMs) to ischemia/reperfusion (I/R) injury. NRVMs were exposed to hypoxic medium for 4 hours, followed by oxygenated complete medium for 16 hours. Acute treatment with 5 mM glucosamine showed an increase in viability and decreased both necrosis and apoptosis following I/R. Glucosamine increased O-GlcNAc levels maximally at 2 hours and went …

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Microbial Biofilm Attachment To Caenorhabditis Elegans, Kevin Drace Jan 2008

Microbial Biofilm Attachment To Caenorhabditis Elegans, Kevin Drace

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The closely related bacterial species Xenorhabdus nematophila, Yersinia pestis and Y. pseudotuberculosis make biofilms capable of adhering to the head of the model nematode Caenorhabditis elegans. Y. pestis uses biofilms to block the digestive tract of its vector, the flea, in order to enhance its efficiency of transmission. I investigated the role of biofilms in X. nematophila and found that, like its Yersinia sp. counterparts, production of biofilm requires a four-gene operon: hmsHFRS. X. nematophila is an insect pathogen and an obligate symbiont of the nematode Steinernema carpocapsae. However, an X. nematophila hmsH mutant that failed to make biofilms on …

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Examining Pre-Service Instructors' Use Of Powerpoint Based On Pre-Service Students' Perceptions: A Mixed Methods Study, Jennifer Fritschi Jan 2008

Examining Pre-Service Instructors' Use Of Powerpoint Based On Pre-Service Students' Perceptions: A Mixed Methods Study, Jennifer Fritschi

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This study explored pre-service instructors’ use of PowerPoint based on pre-service students’ perceptions, and it identified pre-service students’ perceptions of the efficacy of specific elements of PowerPoint design and delivery. The effectiveness of various elements of PowerPoint design and delivery was based on an extensive literature review and was framed on the Cognitive Theory of Multimedia (Mayer, 2000). The findings of the study identified pre-service instructors’ practices and pre-service students’ perceptions of the effectiveness of specific elements of design and delivery and were then compared with what research and expert literature purported were effective. This one year study was conducted …

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Phenomenological Study: What Are Pre-Kindergarten Teachers' Lived Experiences With Children Identified With Conduct Disorder, Oppositional Defiance Disorder, And Attention-Deficit Hyperactivity Disorder In The Southeastern United States?, Danna Benefield Jones Jan 2008

Phenomenological Study: What Are Pre-Kindergarten Teachers' Lived Experiences With Children Identified With Conduct Disorder, Oppositional Defiance Disorder, And Attention-Deficit Hyperactivity Disorder In The Southeastern United States?, Danna Benefield Jones

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To date, a vast amount of research has been conducted on disruptive behavior dis-orders such as conduct disorder (CD), oppositional defiance disorder (ODD), and atten-tion deficit hyperactivity disorder (ADHD. However, a paucity of research exists in spe-cific areas such as how teachers’ handle students diagnosed with these disorders. The cur-rent situation in pre-kindergarten may undermine the ability of these students to succeed in the school system. This is seen in the fact that a large number of these students are removed from pre-kindergarten programs across the United States (Webster-Stratton, Reid, & Hammond, 2004). Understanding pre-kindergarten teachers’ lived experiences in handling …

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Role Of The Gm/Gn Glycoprotein Complex In The Final Assembly And Egress Of The Human Cytomegalovirus (Hcmv), Magdalena Anna Krzyzaniak Jan 2008

Role Of The Gm/Gn Glycoprotein Complex In The Final Assembly And Egress Of The Human Cytomegalovirus (Hcmv), Magdalena Anna Krzyzaniak

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HCMV consists of a dsDNA genome enclosed by, an icosahedral capsid surrounded by a layer of tegument proteins; the virion structure is enclosed in a lipid envelope rich in virus expressed glycoproteins. The HCMV envelope contains an incompletely defined number of glycoproteins. The glycoprotein M (gM) and glycoprotein N (gN) form a gM/gN protein complex which is the most abundant protein component of the HCMV envelope. Recent studies have indicated that deletion of the viral gene encoding either gM or gN is lethal for HCMV. The gM C-terminal cytoplasmic tail (gM-CT) revealed an acidic cluster and a tyrosine-based trafficking motifs. …

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Transcriptional Regulation Of Cd40 And Class Ii Mhc Molecules In Macrophages And Microglia By Statins, Sun Jung Lee Jan 2008

Transcriptional Regulation Of Cd40 And Class Ii Mhc Molecules In Macrophages And Microglia By Statins, Sun Jung Lee

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Microglia/macrophages are the main intrinsic immune effector cells and the first cell types that respond to a variety of CNS injures. They have important functions including secretion of cytokines/chemokines and antigen presentation, thereby regulating immune responses. Interferon-γ (IFN-γ) is a cytokine involved in many aspects of the immune response, and activates microglia/macrophages to express cell surface antigens such as class II MHC, and co-stimulatory molecules such as CD40. CD40 and class II MHC molecules play a critical role in immune reactivity such as antigen presentation and subsequent T cell activation. However, aberrant CD40 and class II MHC expression have been …

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Interim Monitoring Efficacy, Safety And Futility In Phase Iii Clinical Trials, Qing Li Jan 2008

Interim Monitoring Efficacy, Safety And Futility In Phase Iii Clinical Trials, Qing Li

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Phase III trials often have both efficacy and safety outcomes. Sometimes the safety outcomes are closely associated with the efficacy outcomes. We sought to find a statistical method to treat both efficacy and safety outcomes as bivariate primary outcomes and set up stopping rules at interim stages based on the following criteria: (1) greater safety; (2) greater efficacy; (3) futility. We first examined the internal pilot design to adjust sample size for clinical trials with a bivariate response (efficacy and safety). Three nuisance parameters (two variances and correlation) need to be considered when doing sample size recalculation for the internal …

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The Au-Rich Element Mrna Decay-Promoting Activity Of Brf1 Is Regulated By Mitogen-Activated Protein Kinase Activated Protein Kinase 2, Sushmit Maitra Jan 2008

The Au-Rich Element Mrna Decay-Promoting Activity Of Brf1 Is Regulated By Mitogen-Activated Protein Kinase Activated Protein Kinase 2, Sushmit Maitra

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Regulated mRNA decay is a highly important process for the tight control of gene expression. Inherently unstable mRNAs contain AU-rich elements (AREs) in the 3’ untranslated regions that direct rapid mRNA decay by interaction with decay-promoting ARE-binding proteins (ARE-BPs). The decay of ARE-containing mRNAs is regulated by signaling pathways, which are believed to directly target ARE-BPs. Here, we show that BRF1 involved in ARE-mediated mRNA decay (AMD) is phosphorylated by MAPK-activated protein kinase 2, MK2. In vitro kinase assays using different BRF1 fragments suggest that MK2 phosphorylates BRF1 at four distinct sites, S54, S92, S203, and an unidentified site at …

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Modulation Of Transforming Growth Factor (Tgf)-Ss1 And Its Implications In Breast Cancer Metastasis, Lakisha Dionne Moore Jan 2008

Modulation Of Transforming Growth Factor (Tgf)-Ss1 And Its Implications In Breast Cancer Metastasis, Lakisha Dionne Moore

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Overexpresssion of transforming growth factor (TGF)-β has been implicated in promoting immune suppression, tumor angiogenesis, tumor cell migration, and invasion in many cancers including carcinoma of the breast. Thus, targeted downregulation of TGF-β1 expression in breast cancer in situ and determination of its implications potentially could provide new treatment approaches for disease management. siRNA constructs targeting TGF-β1 were validated and used to develop clonal derivatives of the MDA-MB-435 metastatic breast cancer cell line. Inhibition of TGF-β1 expression in MDA-MB-435 cells showed decrease in migration and invasion in vitro with an increase in proliferation. In vivo analysis indicated a 90% decrease …

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Changes In Short-Term Facilitation Are Opposite At Schaffer Collateral And Temporoammonic Ca1 Synapses In The Developing Rat Hippocampus, Haley E. Speed Jan 2008

Changes In Short-Term Facilitation Are Opposite At Schaffer Collateral And Temporoammonic Ca1 Synapses In The Developing Rat Hippocampus, Haley E. Speed

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Hippocampal CA1 pyramidal neurons integrate and filter spatial, temporal, and sensory information from the entorhinal cortex (EC) for memory storage. Synaptic transmission mediates the processing of incoming information, and recent studies have demonstrated that long-term changes in synaptic strength at CA1 synapses are important for learning and memory. Short-term changes in synaptic strength, occurring on a timescale of milliseconds to minutes, do not require lasting modifications and are rapidly reversible. Termed short-term plasticity, it is known to be important for dynamic gain control of synaptic transmission and neural computation. During late postnatal development, there are extensive developmental changes in rat …

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Analysis Of The Hedgehog Pathway In Pancreatic Adenocarcinoma, Adam Steg Jan 2008

Analysis Of The Hedgehog Pathway In Pancreatic Adenocarcinoma, Adam Steg

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Pancreatic adenocarcinoma (PAC) is the fourth leading cause of cancer mortality in the United States. Despite the use of highly aggressive treatment regimens (surgery, chemotherapy and radiation), almost all patients succumb to metastatic disease within 6-10 months of diagnosis. The hedgehog (HH) signaling pathway was originally discov-ered to play a critical role in mammalian embryological development. Interestingly, re-cent studies have suggested that aberrant expression of this pathway is involved in the initiation and continued growth of PAC. Small molecules that antagonize the transmem-brane protein Smoothened (Smo), a critical signaling component of the HH pathway, have proven effective in decreasing PAC …

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The Effect Of Malaria And Intestinal Helminth Coinfection On Birth Outcomes In Ghana, Nelly J. Yatich Jan 2008

The Effect Of Malaria And Intestinal Helminth Coinfection On Birth Outcomes In Ghana, Nelly J. Yatich

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Several studies have reported the relationship between malaria during pregnancy and adverse pregnancy outcomes including maternal anemia, low birthweight, as well as preterm delivery and small for gestational age infants. Some studies have also demonstrated the linkage between helminth infection and maternal anemia. Few studies have assessed the occurrence of coinfection of these infections in pregnancy and its effects on maternal anemia and birth outcomes. The objective of this dissertation was to assess the effect of malaria and intestinal helminth coinfection on birth outcomes in Ghana. A cross-sectional study of 785 women presenting for delivery in two hospitals in Kumasi, …

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P53-Dependent Neural Stem Cell Death Regulation, Ying Geng Jan 2008

P53-Dependent Neural Stem Cell Death Regulation, Ying Geng

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No abstract provided.

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