Digital Commons Network^™

Market Abuse Directive/Regulation, Timothy Edmonds

Documents

No abstract provided.

Of The People, By The People, For The People: Critical Pedagogy And Government Information, Melanie Maksin

Library Staff Publications

This chapter focuses on pedagogical frames and techniques that encourage student engagement and problematize the process-and-product model of government information. These strategies reflect four interconnected ideas, namely

• that government information is political,

• that access to government information is political,

• that government information has value both in scholarly contexts and in individuals’ daily lives, and

• that we can intervene in the production and dissemination of government information.

Nota Bene: Annual Report Issue, Winter 2016-17, Amanda Patrick

Yale University Library Annual Reports

Nota Bene is published during the academic year to acquaint the Yale community and others with the resources of the Yale Library.

Rereading SōSeki: Three Early Twentieth-Century Japanese Novels, Reiko Abe Auestad

CEAS Reprint Series for Rare and Out of Print Publications

For the first project in the Council on East Asian Studies’s reprint series for rare and out of print publications, we are pleased to introduce an electronic republication of Rereading Sōseki: Three Early Twentieth-Century Japanese Novels, a very influential work from 1998 on the celebrated Japanese novelist Natsume Sōseki, written by Reiko Abe Auestad of the University of Oslo. J. Keith Vincent of Boston University has written a new introduction, and Auestad has provided a new preface as well as a bibliography of recent critical studies on Sōseki. We would like to thank John Whittier Treat for recommending this …

Western North Pacific Integrated Physical-Biogeochemical Ocean Observation Experiment (Inbox): Part 1.Specifications And Chronology Of The S1-Inbox Floats, Ryuichiro Inoue, Toshio Suga, Shinya Kouketsu, Toshiyuki Kita, Shigeki Hosoda, Taiyo Kobayashi, Kanako Sato, Hiroyuki Nakajima, Takeshi Kawano

Journal of Marine Research

An interdisciplinary project called the Western North Pacific Integrated Physical-Biogeochemical Ocean Observation Experiment (INBOX) has been conducted since 2011. In the oligotrophic subtropics south of the Kuroshio Extension near biogeochemical mooring S1 (30° N, 145° E), 18 floats, each with a dissolved oxygen sensor, have been deployed in a 150 × 150 km square area. With the horizontal (30 km) and temporal (2 days) resolution of the data, we observed an upper ocean structure associated with mesoscale eddies and ocean responses to atmospheric forcing. The data set obtained from the S1-INBOX study was used to elucidate the impacts of physical …

Western North Pacific Integrated Physical-Biogeochemical Ocean Observation Experiment (Inbox): Part 3. Mesoscale Variability Of Dissolved Oxygen Concentrations Observed By Multiple Floats During S1-Inbox, Shinya Kouketsu, Ryuichiro Inoue, Toshio Suga

Journal of Marine Research

As part of the interdisciplinary project S1-INBOX (Western North Pacific Integrated Physical-Biogeochemical Ocean Observation Experiment conducted around the S1 biogeochemical mooring site), we used data from more than 18 floats and a biogeochemical mooring S1 (near 30° N, 145° E) to investigate temporal and spatial changes in the shallow oxygen maximum (SOM) associated with a mesoscale cyclonic eddy. On the northern edge of the cyclonic eddy, patches (linear dimensions of 20–40 km) with relatively high oxygen concentrations were observed around the SOM. The patterns of the oxygen concentrations reflected the fact that changes of the depths of the isopycnal surfaces …

Meta-Analysis: Risk Of Tics With Psychostimulant Use In Randomized, Placebo-Controlled Trials, Stephanie Celeste Cohen

Yale Medicine Thesis Digital Library

Clinical practice currently restricts the use of psychostimulant medications in children with tics or a family history of tics for fear that tics will develop or worsen as a side effect of treatment. Our goal was to conduct a meta-analysis to examine the risk of new onset or worsening of tics as an adverse event of psychostimulants in randomized, placebo-controlled trials.

We conducted a PubMed search to identify all double-blind, randomized, placebo-controlled trials examining the efficacy of psychostimulant medications in the treatment of children with attention-deficit/hyperactivity disorder (ADHD). We used a fixed effects meta-analysis with risk ratio of new onset …

Baroclinic Instability Over Topography: Unstable At Any Wave Number, Joseph Pedlosky

Journal of Marine Research

The instability of an inviscid, baroclinic vertically sheared current of uniform potential vorticity, flowing along a uniform topographic slope, becomes linearly unstable at all wave numbers if the flow is in the direction of propagation of topographic waves. The parameter region of instability in the plane of scaled topographic slope versus wave number then extends to arbitrarily large wave numbers at large slopes. The weakly nonlinear treatment of the problem reveals the existence of a nonlinear enhancement of the instability close to one of the two boundaries of this parametrically narrow unstable region. Because the domain of instability becomes exponentially …

Carbon Cycling In Santa Barbara Basin Sediments: A Modeling Study, David J. Burdige, Tomoko Komada, Cédric Magen, Jeffrey P. Chanton

Journal of Marine Research

The primary input of organic matter to almost all marine sediments comes from deposition at the sediment surface. However, in many continental margin settings, reduced carbon can also be added to sediments from below—for example, from “deep” geologic hydrocarbon reservoirs derived from ancient source rocks or from the decomposition of deeply buried gas hydrate deposits. To examine the impact of these two differing reduced carbon inputs on sediment biogeochemistry, a modified reaction-transport model for anoxic marine sediments is described here and applied to data from sediment cores in Santa Barbara Basin to a depth of 4.6 m. Excellent model fits …

Mechanisms Controlling Vertical Variability Of Subsurface Chlorophyll Maxima In A Mode-Water Eddy, Qian P. Li, Dennis A. Hansell

Journal of Marine Research

An intense subsurface chlorophyll enhancement was found repeatedly within the core of a mode-water eddy during a 2-month period. Two controls on chlorophyll concentrations in this deep chlorophyll maximum (DCM) layer are noted: chlorophyll concentration is controlled by nutrients at low nutrient concentrations and by light when nutrients are saturating. To synthesize these results, a simple one-dimensional nutrient-phytoplankton model is developed by including the effects of phytoplankton self-shading for light attenuation, depth-dependent phytoplankton specific loss, and density-associated nutrient fluctuation in the deep layer. The model is parameterized using eddy data including not only vertical diffusivity, sinking velocity, and chlorophyll-to-carbon ratios, …

Convective Mixing By Internal Waves In The Puerto Rico Trench, Hans Van Haren, Louis Gostiaux

Journal of Marine Research

A 2.4 km long deep-sea mooring was deployed for 14 months in the Puerto Rico Trench, the deepest part of the Atlantic Ocean. Below its top buoyancy package, the mooring line held a 200 m long string of high-resolution temperature sensors and a current meter. Over the instrumented range between 6,004 and 6,204 m, waters are very weakly stratified, with local buoyancy frequency equaling about 1.9 times the semidiurnal tidal frequency. Besides quiescent waters, the detailed observations show regular vertical turbulent overturning associated with periodic warming and driven by internal tidal and inertial waves. During such episodes, the 4-day and …

Methane Dynamics In Santa Barbara Basin (Usa) Sediments As Examined With A Reaction-Transport Model, David J. Burdige, Tomoko Komada, Cédric Magen, Jeffrey P. Chanton

Journal of Marine Research

Here we describe a new reaction-transport model that quantitatively examines δ¹³C profiles of pore-water methane and dissolved inorganic carbon (DIC) (δ¹³C_CH4 and δ¹³C_DIC) in the anoxic sediments of the Santa Barbara Basin (California Borderland region). Best-fit solutions of the model to these data suggest that CO₂ reduction is the predominant form of methanogenesis in these sediments. These solutions also accurately reproduce the isotope depth profiles, including a broad minimum in the δ¹³C_DIC profile and a much sharper (angular) minimum in the δ¹³C_CH4 profile, both …

Western North Pacific Integrated Physical-Biogeochemical Ocean Observation Experiment (Inbox): Part 2. Biogeochemical Responses To Eddies And Typhoons Revealed From The S1 Mooring And Shipboard Measurements, Ryuichiro Inoue, Makio C. Honda, Tetsuichi Fujiki, Kazuhiko Matsumoto, Shinya Kouketsu, Toshio Suga, Toshiro Saino

Journal of Marine Research

An interdisciplinary project called S1-INBOX (Western North Pacific Integrated PhysicalBiogeochemical Ocean Observation Experiment conducted around the S1 biogeochemical mooring site) was carried out during the summer of 2011 in the oligotrophic, subtropical North Pacific Ocean near biogeochemical mooring S1 (30° N, 145° E). Results from the S1 mooring during S1-INBOX revealed a large export flux at a depth of 200 m, a high chlorophyll a concentration in the deep chlorophyll maximum layer, and a high potential photochemical efficiency of photosystem II. These phenomena were associated with vertical uplift of isopycnal surfaces at the edge of a cyclonic eddy and a …

Residual Water Transport In The Marsdiep Tidal Inlet Inferred From Observations And A Numerical Model, Maximiliano G. Sassi, Theo Gerkema, Matias Duran-Matute, Janine J. Nauw

Journal of Marine Research

At tidal inlets, large amounts of water are exchanged with the adjacent sea during the tidal cycle. The residual flows, the net effect of ebb and flood, are generally small compared with the gross flux; they vary in magnitude and sign from one tidal period to the other; and their long-term mean varies from year to year. Here, we focus on the temporal variability of the residual flows in the Marsdiep tidal inlet, which is the western-most inlet of the Wadden Sea, a tidal lagoon along the coasts of the Netherlands, Germany, and Denmark. We compare the transport from a …

An Automated Temporal, Amplitude, And Complexity-Based Comparison Of Commercial Plethysmographs, Matthew Mikhail

Yale Medicine Thesis Digital Library

The study of plethysmographic physiology has been limited by a lack of standardized and open plethysmographic hardware in clinical use. Fundamental differences in the processing of output between various devices obfuscate direct comparison, and the role played by physiology versus that by technology in the final viewable plethysmogram (PPG). This study proposes a largely automated, unbiased method for quantitatively comparing the outputs from proprietary pulse oximeter devices along three metrics: temporal delay, amplification, and complexity. It then applies these methods to the deconstruction of Masimo and Nellcor pulse oximeters.

With IRB approval, twelve healthy, awake subjects were studied. Each individual …

Bamc Half-Year Report 2016, Bank Assets Management Company (Bamc)/Družba Za Upravljanje Terjatev Bank, D.D. (Dutb)

Documents

No abstract provided.

Teaching Experiences In Medical School And Projected Confidence In Teaching During Residency And Career Plans In Medical Education., Isha Marina Di Bartolo

Yale Medicine Thesis Digital Library

Teaching experiences in medical school and projected confidence in teaching during residency and career plans in medical education.

Isha Di Bartolo, Michael R. O’Brien, and Michael Green.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.

Teaching is an important part of being a physician and of being a physician-in-training. Although training to be an effective teacher is already a part of the curricula of many residency programs, it remains unclear what teaching experiences are available to medical students and how these students are affected by these experiences. The aim of this study is to qualify the …

Retrospective Assessment Of Treatment With T-Dm1 After Pertuzumab In Her2-Positive Metastatic Breast Cancer, Hannah Elizabeth Dzimitrowicz

Yale Medicine Thesis Digital Library

T-DM1/ ado-trastuzumab emtansine, the most recent addition to the HER2-targeted therapies approved to treat HER2-positive metastatic breast cancer (MBC), is an antibody-drug conjugate with a favorable side effect profile. T-DM1 is currently approved for patients with HER2-positive MBC who previously received trastuzumab and a taxane. Since the trial resulting in T-DM1 approval was conducted, the standard first-line therapy for metastatic HER2-positive breast cancer has changed from trastuzumab and a taxane to a three-drug combination of trastuzumab and a taxane plus pertuzumab. Due to the timing of these approvals, there is no clinical trial or observational data on the activity of …

Assessment Of Specific T-Cell Receptor Engagement Without Necessity For Identification Of The Relevant Antigen, Harib Hassan Ezaldein

Yale Medicine Thesis Digital Library

Individual cancers, even of the same cell type, express unique arrays of distinctive tumor antigens, requiring accurate laboratory measurement of induced immunity against them problematic. Fluorescently tagged reagents (dextramers) that selectively engage clonal T-cell receptors (TCR) can cytofluorographically quantify both frequency and avidity antigen-specific T-cells, but cannot be synthesized without prior identification of the relevant antigen. Since clinically evident tumors may contain as many as 300 unique point mutations capable of generating a large number of uniquely antigenic proteins, and since procurement of such information for each cancer is currently unrealistic, it is presently only possible to assess responses to …

Clinical Conditions And Cardiac Function: Correlations With Left Atrial Fibrosis By Mri In Subjects With And Without Atrial Fibrillation, Karl Grunseich

Yale Medicine Thesis Digital Library

The purpose of this study was to evaluate the clinical conditions and cardiac functions associated with left atrial (LA) fibrosis by late gadolinium enhancement (LGE). LA LGE has been found to be associated with various measures of cardiac functions, procedural outcomes, and adverse events in patients who already have atrial fibrillation (AF). Assessment of LA fibrosis by LGE in patients without AF has largely been unexamined and comparison of these patients to those with AF could prove useful. This study was a retrospective chart and imaging review of 137 consecutive subjects imaged with a 3D LGE sequence at one institution …

Malignancies Associated With Inflammatory Bowel Diseases, Nicole Gong Jawitz

Yale Medicine Thesis Digital Library

Inflammatory Bowel Diseases (IBD), specifically Crohn’s disease and ulcerative colitis, have been associated with numerous intestinal and extra- intestinal malignancies. Recent studies have suggested use of immunomodulator therapies has increased risks of malignancies, including melanoma, non-epithelial skin cancers, cervical cancer, and bladder and urinary tract cancers. The question regarding how biologic agents, which became a mainstay therapy of IBD in the early 2000s, have influenced malignancy risk among patients with IBD has yet to be definitely answered.

The aims of this study were to characterize prevalence of comorbid malignancies among hospitalized patients with IBD and how it has changed over …

Restoring Consciousness During Seizures With Deep Brain Stimulation, Adam Joseph Kundishora

Yale Medicine Thesis Digital Library

Impaired consciousness occurs suddenly and unpredictably in people with epilepsy, markedly worsening quality of life and increasing risk of mortality. Focal seizures with impaired consciousness are the most common form of epilepsy, and are refractory to all current medical and surgical therapies in about one sixth of cases. Restoring consciousness during and following seizures would be potentially transformative for these individuals. Here, we investigate deep brain stimulation to improve level of conscious arousal in a rat model of focal limbic seizures. We found that dual-site stimulation of the thalamic intralaminar central lateral nucleus (CL) and pontine nucleus oralis (PnO) bilaterally …

Short-Term Outcomes And Long-Term Prognosis In Oral Cavity Cancer, Zachary Gregg Schwam

Yale Medicine Thesis Digital Library

SHORT-TERM OUTCOMES AND LONG-TERM PROGNOSIS OF ORAL CAVITY CANCER. Zachary G. Schwam, Benjamin L. Judson (advisor). Section of Otolaryngology, Department of Surgery, Yale University School of Medicine, New Haven, CT.

We sought to characterize short-term morbidity and mortality outcomes as well as long-term changes in prognosis for oral cancer patients. We predicted that clinical and demographic variables would affect short- and long-term outcomes. Retrospective analyses of the National Surgical Quality Improvement Program (NSQIP) and National Cancer Database (NCDB) were performed on 408 and 13,655 patients, respectively. Chi-square, Kaplan Meier, logistic regression, and Cox proportional hazards regression were performed. In the …

Ethical Challenges In Student Global Health Research Projects, Katherine Rebecca Standish

Yale Medicine Thesis Digital Library

U.S. students are participating in global health electives and research in low- and middle-income countries (LMIC) in increasing numbers, yet the significant ethical challenges they face have not been well documented. We conducted a mixed methods study of graduate, health professional and undergraduate students at a research-focused university about their experiences conducting global health research activities, focusing on ethical challenges and support for addressing those challenges. An online, structured questionnaire was completed by 123 participants, and in-depth, semi-structured interviews were conducted with 17 participants and analyzed using the constant comparison method. Among questionnaire respondents, 31% reported a significant or moderate …

Insulin Dependence Heralds Adverse Events After Hip And Knee Arthroplasty, Matthew Webb

Yale Medicine Thesis Digital Library

ABSTRACT

Background – Total hip arthroplasty (THA) is one of the most frequently performed orthopaedic procedures. As the prevalence of diabetes mellitus (DM) continues to increase the burden of its sequelae and associated surgical complications have also increased. For these reasons, it is important to understand the associations between DM and the rates of perioperative adverse events in patients with DM who will undergo THA.

Methods – The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database records perioperative adverse events as well as patient factors including demographics and comorbidities. Patients who underwent THA between 2005 and …

Library E-Book Platforms Are Broken: Let's Fix Them, Joelle Thomas, Galadriel Chilton

Library Staff Publications

E-books promise users convenience and accessibility, but library e-book platforms contain so many barriers to use and access that patrons often turn away in frustration. In addition, aggregators’ e-book platforms often include intrusive, onerous digital rights management (DRM) restrictions. The traditional solution of DRM-free e-books are generally only available only in large and expensive publisher packages. One approach to solving these problems is an evidence-based selection of e-books program; it not only offers access to hundreds of DRM-free, unlimited simultaneous-user e-books that are integrated with similar e-journal content, but also includes an agreement that libraries will only purchase titles with …

Notch Drives Proliferation And Radiation Resistance Of Cancer Stem Cells In Adenoid Cystic Carcinoma, Michael T. Chang

Yale Medicine Thesis Digital Library

Adenoid cystic carcinoma (ACC) of the salivary gland is an indolent but highly lethal neuroinvasive tumor with a propensity for radiation resistance, recurrence, and metastasis. Molecular understanding of this rare tumor has been hampered by the absence of validated in vitro models and a limited number of xenografts. Therapeutic options for ACC are limited to surgery and radiation and are associated with an unacceptably low rate of cure. Cancer stem cells (CSC) are an attractive therapeutic target, and understanding their role in ACC may advance therapy. Our objectives were: 1) to establish and validate ACC cell cultures, 2) to determine …

Characterizing Parental Adherence To Amblyopia Therapy At Menelik Ii Referral Hospital In Addis Ababa, Ethiopia, Bethlehem Dessalegn Mekonnen

Yale Medicine Thesis Digital Library

There are limited studies completed in the East African region to assess barriers to adherence with amblyopia treatment and outcomes of this treatment. Our study aims to identify factors which are associated with higher adherence in amblyopia treatment. Institutional Review Board (IRB) approval was obtained and a hospital-based retrospective and prospective observational study was performed at the pediatric ophthalmology clinic of Menelik II Referral Hospital in Addis Ababa, Ethiopia from March 2015 to June 2015. Included in the study were Ethiopian children, between the ages of 4 and 8, with a clinical diagnosis of amblyopia defined as interocular acuity difference …

The Effect Of Wind Direction On Cross-Shelf Transport On An Initially Stratified Inner Shelf, Rachel M. Horwitz, Steven J. Lentz

Journal of Marine Research

Cross-shelf and along-shelf wind stresses both independently have been shown to drive transport across the inner shelf. We investigate how the circulation and density fields respond to simultaneous cross- and along-shelf wind forcing using a set of model experiments on an initially stratified inner shelf. For all wind directions with a downwelling along-shelf component, the inner shelf is unstratified and the cross-shelf wind dominates transport. For wind directions with an upwelling along-shelf component, the inner shelf can be stratified and the transition from inner to midshelf occurs over a wide swath of shelf. In this transition region, the effects of …

Vorticity Dynamics Near Sharp Topographic Features, Bruno Deremble, William K. Dewar, Eric P. Chassignet

Journal of Marine Research

In ocean models, the interaction with boundaries is often parameterized as it involves small-scale processes that are usually hard to capture in a large-scale model. However, such interactions can play important roles in the model dynamics. For example, the choice of boundary conditions (free-slip vs. no-slip) has a direct impact on the vorticity (enstrophy) budget: with no-slip boundary conditions, vorticity is injected into the system, whereas with free-slip boundary conditions, there should be no vorticity injection as long as the coastline is smooth. However, we show here that at boundary singularities (e.g., corners), vorticity is injected into the domain even …