Digital Commons Network^™

Evaluating The Utility Of Spect/Ct Imaging Of Angiosome Perfusion In Diabetic Patients With Critical Limb Ischemia, Jessica Buckley

Yale Medicine Thesis Digital Library

EVALUATING THE UTILITY OF SPECT/CT IMAGING OF ANGIOSOME PERFUSION IN DIABETIC PATIENTS WITH CRITICAL LIMB ISCHEMIA.

Jessica L. Buckley, Albert J. Sinusas, Mitchel R. Stacy. Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.

Impaired lower extremity perfusion is a hallmark of peripheral arterial disease (PAD) and is particularly problematic in diabetic patients, who suffer from high rates of PAD, ulceration, and lower extremity amputation. The ability to non-invasively detect deficits in microvascular perfusion within vascular territories, or angiosomes, of the feet may provide information related to tissue viability and guide therapeutic interventions. …

Demethylation Therapy As A Novel Treatment For Human Papilloma Virus-Associated Head And Neck Cancer, Michael Hajek

Yale Medicine Thesis Digital Library

5-azacytidine (5-aza) and its structural analog 5-aza-2’-deoxycytidine (decitabine) are demethylating agents currently used to treat myelodysplastic syndrome and acute myeloid leukemia. In addition to demethylating DNA, they are known to cause DNA damage and activate DNA damage response pathways, but our mechanistic understanding of these processes is incomplete. Given the unique epigenetic profile of human papilloma virus-associated (HPV+) head and neck squamous cell carcinoma (HNSCC), we sought to develop demethylation therapy as a novel, targeted treatment for this subset of cancer that has less morbidity than current treatments. We wanted to characterize the DNA damage and describe the mechanism of …

National And Institutional Outcomes Data In Head And Neck Cancers, And Functional And Patient Reported Outcomes In Patients With Oropharyngeal Cancers, Ankit Kansal

Yale Medicine Thesis Digital Library

Background and Purpose: To determine the availability of outcomes data to head and neck cancer patients. To create a database of comprehensive information including demographics, process metrics, and outcomes for head and neck cancer patients who were diagnosed or treated at a Yale New Haven Hospital affiliate. To examine factors affecting functional and patient reported outcomes in patients with oropharyngeal cancers.

Materials and Methods: The websites of all NCI-designated Cancer Centers and all affiliated institutions were examined for publicly available data regarding head and neck cancer patients. For Yale data, IRB approval was obtained to use tumor registry data, as …

Novel Application Of Untargeted Metabolomics To Diseases Of Neurosurgical Significance, Alex Yang Lu

Yale Medicine Thesis Digital Library

Metabolomics, an emerging technique to study hundreds of small-molecule metabolites simultaneously, has been seldom applied to diseases of neurosurgical significance. We utilized metabolomics to explore two distinct questions: 1. to identify global metabolic changes and metabolite predictors of long-term outcome in aneurysmal subarachnoid hemorrhage (SAH) patients, 2. to identify differential metabolites profiles of radiation necrosis vs. recurrent tumor of metastatic brain lesions post-Gamma Knife radiosurgery. The first study applied gas chromatography time-of-flight mass spectrometry (GC-TOF) to cerebrospinal fluid samples collected from 15 high-grade aSAH patients (modified Fisher grades 3 and 4). Analysis was performed at two time points; metabolite levels …

Concussion Biomarker Discovery For Prognosis In Adolescent Athletes (Compete) Pilot Study, Sean N. Mbachu

Yale Medicine Thesis Digital Library

Concussion management in the ED is inconsistent due to a lack of available empirical testing. This project aims to assess the feasibility of a large multi-centered study for concussion biomarker discovery in the ED.

This prospective cohort pilot and feasibility study was conducted in the adult and pediatric EDs of an urban, academic, Level 1 trauma center. Twelve patients with concussions and twelve age- and gender-matched control patients presenting within 6 hours of an injury sustained during recreational activity were enrolled. ED blood specimens were banked for future proteomic analysis. Clinical outcomes were collected via online survey. Patient recruitment strategies …

The Evolution Of Restraint In American Psychiatry, Danilo Alejandro Rojas-Velasquez

Yale Medicine Thesis Digital Library

History/Social Science:

The Evolution of Restraint in American Psychiatry

Author: Danilo Rojas-Velasquez

In psychiatry, restraint generally refers to direct methods such as mechanical restraints or the use of drugs. Despite psychiatrists’ best efforts to utilize restraint judiciously, many patients still view it as the field’s defining feature, especially on inpatient units with involuntary commitment, medications against will, and locked doors. This essay is an attempt to understand the pervasiveness of restraint in psychiatry. It uses changes in the practices of restraint to examine the growth of the field over time. To accomplish this, the paper identifies three distinct regimes of …

Predicting Response To Anti-Pd-1 Immunotherapy In Metastatic Melanoma, James William Smithy

Yale Medicine Thesis Digital Library

Predictive biomarkers for antibodies against programmed death 1 (PD-1) remain a major unmet need in metastatic melanoma. Thus, we evaluated three alternative tissue- and blood based markers biomarkers for response to anti-PD-1 therapy. First, pre-treatment melanoma samples were assayed for expression of: 1) IRF-1, a PD-L1 transcription factor, as a proxy for a tumor’s capacity to express PD-L1, and 2) an immune activation panel consisting of CD3, Ki67, and Granzyme B to distinguish immune-active and immune-quiescent tumors. Additionally, we conducted pilot studies to determine the feasibility of measuring soluble PD-L1 in the plasma of cancer patients.

For tissue-based assays, samples …

Development Of A Clinical Decision Rule For Subarachnoid Hemorrhage Headache In The Emergency Department, Linh H. Vu

Yale Medicine Thesis Digital Library

Subarachnoid hemorrhage (SAH) is a neurological emergency associated with high morbidity and mortality. It has a pre-hospital mortality rate of up to 50%, and can cause severe disability or death in 40-60% of patients. A prompt diagnosis is crucial for timely work-up and intervention. It is still frequently missed, especially in alert patients who present with an acute headache as the only chief complaint. Acute headache is the 5th leading reason for Emergency Department (ED) visits. It accounts for about 3% of all ED visits in the US. Of these, ~2% will be secondary to aneurysmal SAH.

Some guidelines have …

The Natural History And Predictors Of Liver Fibrosis Progression Using The Fib-4 Score Among Hiv/Hcv Co-Infected Adults In An Outpatient Clinic, Bianca Yuh

Yale Medicine Thesis Digital Library

Background: Studies have documented more rapid progression of HCV-associated liver fibrosis in patients co-infected with HIV. However, the natural history of HCV infection in both mono-infected and HIV co-infected patients remains highly variable. The patterns and predictors of fibrosis progression in the HIV/HCV co-infected population are not fully characterized. Given the invasiveness of serial liver biopsies, Fibrosis-4 score (FIB-4), a composite of serum biomarkers that correlate well with fibrosis stage, is increasingly used. We used FIB-4 to study the natural history of liver fibrosis progression among co-infected patients and evaluated predictors of progression to cirrhosis over 5 years prior to …

Data Assimilation For Initialization Of Seasonal Forecasts, Magdalena A. Balmaseda

Journal of Marine Research

This article reviews the requirements for a data assimilation system from the perspective of initializing seasonal forecasts. It provides a historical perspective of the developments in ocean data assimilation and ocean observing systems. It also discusses the differences between state estimation and initialization, and presents a brief assessment of different initialization strategies. The value of assimilating ocean data to estimate the ocean state and to initialize seasonal forecasts is demonstrated. However, it is also shown that the assumption of unbiased models in conventional data assimilation methods is not suitable for the production of long temporal records of ocean initial states. …

Medicine@Yale January/February 2017 Volume 13, Issue 1, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Of A Healthy Constitution: Socialized Medicine Between The Triumphs Of Social Security And Medicare, Sarah D. Kim

Kaplan Senior Essay Prize for Use of Library Special Collections

In January 1937, Thomas Thacher, a former solicitor general of the United States under President Hoover, gave a talk at the annual meeting of the American Academy of Medicine. He attacked socialized medicine as a “fallacy” that would “blanket the country without regard to local conditions and individuals.” He also expressed doubts about the constitutionality of socialized medicine under the proposed system of compulsory health insurance, adding that states had no power to enforce funding for it. (Funding for such insurance would entail a sliding scale of costs between those in the upper and middle-income brackets, or to take money …

Maping Collection Use: Using Massive Analysis Projects For Collections Analysis, Galadriel Chilton, Joelle Thomas, Alice Fairfield, Arta Dobbs, Elisabeth Umpleby, Dawn Cadogan

Library Staff Publications

From The Library Assessment Cookbook, edited by Aaron W. Dobbs (http://www.alastore.ala.org/detail.aspx?ID=12238, ISBN: 9780838988664), this recipe outlines the assessment of resources that are similar in size, scope, coverage, and typical user population. While this recipe was first used at an academic institution, it could be adapted for public, state, school, or special libraries.

Creating A Framework For Comprehensive Collection Assessment, Galadriel Chilton

Library Staff Publications

From The Library Assessment Cookbook, edited by Aaron W. Dobbs (http://www.alastore.ala.org/detail.aspx?ID=12238, ISBN: 9780838988664), this recipe outlines the objectives, project management framework, and deliverables created to enable a comprehensive review and assessment of the library's e-resources.

Influence And Effectiveness In The Years Of Upheaval: Winston Lord And The Policy Planning Staff From 1973 To 1977, Max L.B. Cook

Harvey M. Applebaum ’59 Award

This two-semester senior essay submitted in completion of the History major at Yale University focuses broadly on the formation of U.S. long-term foreign policy in the Cold War period. More specifically, it analyzes the influence of the State Department’s Policy Planning Staff (S/P) and its Director Winston Lord (YC ’59) from 1973 to 1977 on the decision-making and policy formulation of Secretary of State Henry Kissinger. In this period, the S/P took the lead on cross-agency issues, linked operational policy decisions with established long-term U.S. strategic principles, and in some issue areas directly defined U.S. policy on behalf of Secretary …

Choose Or Chosen? An Interactive Exploration Of Congressional District Boundaries, Steven M. Roets

Library Map Prize

No abstract provided.

The Macroprudential Policy Framework In Russia, Elizaveta Danilova, Maxim Morozov

Documents

No abstract provided.

Evaluating The Impact Of Macroprudential Policies In Colombia's Credit Growth, Esteban Gómez, Angèlica Lizarazo, Juan Carlos Mendoza, Andrès Murcia

Documents

No abstract provided.

High Frequency Trading And The 2008 Short-Sale Ban, Jonathan Brogaard, Terrence Hendershott, Ryan Riordan

Documents

No abstract provided.

What Exactly Is Market Integrity? An Analysis Of One Of The Core Objectives Of Securities Regulation, Janet Austin

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No abstract provided.

Annual Report 2017, Magyar Nemzeti Bank (Mnb)

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No abstract provided.

Federal Open Market Committee Rules And Authorizations (January 2017), Federal Reserve System: Board Of Governors: Federal Open Market Committee (Fomc)

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No abstract provided.

Nama Land, Frank Connolly

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No abstract provided.

Annual Report Of The State Audit Office Of The Republic Of Latvia 2016, Republic Of Latvia: State Audit Office

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No abstract provided.

A Diary Of The Euro Crisis In Cyprus: Lessons For Bank Recovery And Resolution, Panicos Demetriades

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No abstract provided.

Cbsl Annual Report 2016, Central Bank Of Sri Lanka (Cbsl)

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No abstract provided.

2016 Annual Report, Bank Of Mongolia (Mongolbank)

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No abstract provided.

Financial Stability Report 2017/2, Central Bank Of Iceland

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No abstract provided.

Annual Report Of Mkb Group 2016, Magyar Külkereskedelmi Bank

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No abstract provided.

Annual Report 2016, Dexia

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No abstract provided.