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Ypfs Lessons Learned Oral History Project: An Interview With Salvatore Antonio Fratto, Mercedes Cardona, Salvatore Antonio Fratto

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Suggested Citation Form: Fratto, Salvatore Antonia, 2019. “Lessons Learned Interview."Interview by Mercedes Cardona. Yale Program on Financial Stability Lessons Learned Oral History Project. January 19, 2019. Transcript. https://ypfs.som.yale.edu/library/ypfs-lesson-learned-oral-history-project-interview-tony-fratto

A Global Database Of Surface Urban Heat Island Intensity, Tc Chakraborty, Xuhui Lee

Yale Day of Data

The urban heat island (UHI) effect - the phenomenon of higher temperatures in urban environments - is one of the most well-known consequences of urbanization on local climate. We develop the simplified urban-extent (SUE) algorithm, a new algorithm to estimate the urban heat island (UHI) intensity at a global scale. This algorithm is implemented on the Google Earth Engine platform and uses satellite-derived images to calculate the surface UHI intensity for over 9500 urban clusters covering 15 years, making this the most comprehensive global UHI database. The data are validated against previous multi-city studies and then used to estimate the …

Text-Speech Alignment: A Robin Hood Approach For Endangered Languages, Claire Bowern, Rikker Dockum, Sarah Babinski, Hunter Craft, Anelisa Fergus, Dolly Goldenberg

Yale Day of Data

Forced alignment automatically aligns audio recordings of spoken language with transcripts at the level of individual sounds, greatly reducing the time required to prepare data for linguistic analysis. However, existing algorithms are mostly trained on a few well-documented languages. We test the performance of three algorithms against manually aligned data on data from a highly endangered language. At least some tasks, unsupervised alignment (either based on English or trained from a small corpus) is sufficiently reliable for it to be used on legacy data for low-resource languages. Descriptive phonetic work on vowel inventories and prosody can be accurately captured by …

Gene Co-Expression Networks Analysis Reveal Novel Molecular Endotypes In Alpha-1 Antitrypsin Deficiency, Jen-Hwa Chu, Wenlan Zang

Yale Day of Data

Rationale:Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that predisposes to early onset pulmonary emphysema and airways obstruction. The exact mechanism through which AATD leads to lung disease is incompletely understood.

Objectives: To investigate the effect of AAT genotype and augmentation therapy on bronchoalveolar lavage (BAL) and peripheral blood mononuclear cells (PBMC) transcriptome, while examining the link between gene expression profiles, and clinical features of AATD.

Methods: We performed RNA-Seq on RNA extracted from BAL and PBMC on samples obtained from 89 AATD patients enrolled in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study. Differential …

Topovar90m: Global High-Resolution Topographic Variables For Environmental Modeling, Giuseppe Amatulli Dr.

Yale Day of Data

Topographical relief involves the vertical and horizontal variation of the Earth's terrain and it drives processes in hydrology, climatology, geography and ecology. Its assessment and characterization is fundamental for various types of modeling and simulation analysis. In this regard, the Multi-Error-Removed Improved Terrain (MERIT) Digital Elevation Model (DEM) currently provides the best high-resolution DEM globally available, at a 3 arc-second resolution (90m), due to the removal of multiple error components from the underlying SRTM3 and AW3D30 DEMs. To depict topographical variations worldwide, we developed a new dataset comprising different terrain features derived from the MERIT-DEM. The fully standardized topographical variables …

Non-Invasive Analysis Of The Sputum Transcriptome Discriminates Clinical Phenotypes Of Asthma, Xiting Yan

Yale Day of Data

Whole transcriptome wide gene expression profiles in the sputum and circulation from 100 asthma patients were measured using the Affymetrix HuGene 1.0ST arrays. Unsupervised clustering analysis based on pathways from KEGG were used to identify TEA clusters of patients from the sputum gene expression profiles. The identified TEA clusters have significantly different pre-bronchodilator FEV1, bronchodilator responsiveness, exhaled nitric oxide levels, history of hospitalization for asthma and history of intubation. Evaluation of TEA clusters in children from Asthma BRIDGE cohort confirmed the identified differences in intubation and hospitalization. Furthermore, evaluation of the TH2 gene signatures suggested a much lower prevalence of …

A Novel Pathway-Based Distance Score Enhances Assessment Of Disease Heterogeneity In Gene Expression, Yunqing Liu, Xiting Yan

Yale Day of Data

Distance-based unsupervised clustering of gene expression data is commonly used to identify heterogeneity in biologic samples. However, high noise levels in gene expression data and the relatively high correlation between genes are often encountered, so traditional distances such as Euclidean distance may not be effective at discriminating the biological differences between samples. In this study, we developed a novel computational method to assess the biological differences based on pathways by assuming that ontologically defined biological pathways in biologically similar samples have similar behavior. Application of this distance score results in more accurate, robust, and biologically meaningful clustering results in both …

Gender And The Yale Faculty: A View Of The Data, Emily Stark, Nancy Ruther, Paula Kavathas, Claire Bowern

Yale Day of Data

Every five years, the Women Faculty Forum compiles the demographics of the University’s faculty in a report called “The View.” The findings of The View of 2016-2017 belong in the context of a series of structural changes at Yale over the past five years that contribute to a widespread effort to foster gender equity and to recruit, retain, and support a more diverse faculty.

The 2016-2017 report shows the gains made in university leadership (particularly administrative leadership and Heads of College) by women faculty since 2012 but a stagnation in numbers of URM (under-represented minorities) faculty and women with tenured …

Political Attitudes, Cognitive Style, And Political Persuasion, Halbert Bai, Gregory Mitchell, Philip E. Tetlock

Yale Day of Data

How do liberals and conservatives differ? Existing evidence suggests clear divergences on cognitive style and sociopolitical attitudes. However, theories such as the rigidity of the right hypothesis (Adorno et al., 1950; Tetlock, 1983) and the ideologue hypothesis (Rokeach, 1956) make incompatible predictions. The present research aims to reconcile these incongruities by employing measures that assess (a) cognitive style/open-mindedness, (b) perspective-taking, and (c) relationships between characteristics of procedural justice. Study 1 employed real-world arguments on highly politicized issues to examine rhetorical features that influence an article’s persuasiveness. We found evidence for the rigidity of the right hypothesis. In Study 2, participants …

Analyzing Neuronal Dendritic Trees With Convolutional Neural Networks, Olivier Trottier, Jonathon Howard

Yale Day of Data

In the biological sciences, image analysis software are used to detect, segment or classify a variety of features encountered in living matter. However, the algorithms that accomplish these tasks are often designed for a specific dataset, making them hardly portable to accomplish the same tasks on images of different biological structures. Recently, convolutional neural networks have been used to perform complex image analysis on a multitude of datasets. While applications of these networks abound in the technology industry and computer science, use cases are not as common in the academic sciences. Motivated by the generalizability of neural networks, we aim …

A Three State Model Can Explain The Dynamics Of Class Iv Drosophila Dendritic Tips, Sabyasachi Sutradhar

Yale Day of Data

No abstract provided.

Exploring The Ipf Lung Through The Lens Of Single Cell Rna Sequencing, Taylor Adams, Jonas Schupp

Yale Day of Data

This poster illustrates the differences between the IPF disease-specific variety of lung macrophages and the two varieties of macrophages known to reside in the normal human lung.

Guarantee Scheme For Banks' Funding In Finland, Lily Engbith

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No abstract provided.

French Liquidity Support Through The Sfef, Everest Fang, Alexander Nye

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No abstract provided.

Denmark Guarantee Scheme, Keni Sabath

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No abstract provided.

Uk Asset-Backed Securities Guarantee Scheme, June Rhee

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No abstract provided.

Soffin Guarantee Scheme (Germany), Claire Simon, Devyn Jeffereis

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No abstract provided.

Credit Institutions (Eligible Liabilities Guarantee) Scheme, Claire Simon

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No abstract provided.

Italian Guarantee Scheme, Lily Engbith

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No abstract provided.

Dutch Credit Guarantee Scheme, Lily Engbith

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No abstract provided.

Swedish Guarantee Scheme, Lily Engbith, Kevin Kiernan

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No abstract provided.

Greek Credit Guarantee Scheme, Dan Thompson, Devyn Jeffereis

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No abstract provided.

Canadian Lenders Assurance Facility, Claire Simon

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No abstract provided.

Ibsg Guarantee Program, Claire Simon

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No abstract provided.

Discovering The Immune Cell Landscape In Ipf By Whole Lung Single Cell Transcriptomics, Jonas C. Schupp, Taylor Adams

Yale Day of Data

Single cell transcriptomes of 27 IPF, 13 COPD and 14 control lungs were established. Cells were clustered into major cell types, then the immune cells consisting of 116,057 myeloid, 4,742 B-, and 19,165 T-& NK-cells were analyzed and subclustered. Subclustering revealed IPF-associated unique gene expression profiles subpopulations that were specific to the IPF lung. For example, we could identify an IPF-specific macrophage subpopulation which showed a pro-fibrotic profile characterized by SPP1, CHIT1, CCL18, SPARC, LGMN, CTSK, and MMP9 gene expression. Antagonistically, NK- and cytotoxic T-cells revealed a significantly increased expression of the protease inhibitors A2M and PZP in the IPF …

Ypfs Lessons Learned Oral History Project: An Interview With David Wessel, Mercedes Cardona, David Wessel

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Suggested Citation Form: Wessel, David, 2019. “Lessons Learned Interview."Interview by Mercedes Cardona. Yale Program on Financial Stability Lessons Learned Oral History Project. January 15, 2019. Transcript. https://ypfs.som.yale.edu/library/ypfs-lesson-learned-oral-history-project-interview-david-wessel

Sri Lanka Banks On Rbi Swaps To Boost Its Reserves: Pm, Press Trust Of India

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No abstract provided.

Rbi Agrees To Usd 400 Mn Swap - Boost To Reserves, Central Bank Of Sri Lanka (Cbsl)

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No abstract provided.

Banco Popular Bondholders File New Suit Against Eu Body In European Court, Jennifer Laidlaw

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No abstract provided.

Erratum

Journal of Marine Research

Please note the correction to the following article: Bouzaiene, Maher, Milena Menna, Pierre-Marie Poulain, and Dalila Elhmaidi. 2018.“Lagrangian dispersion characteristics in the Western Mediterranean.” Journal of Marine Research 5–6, 139–161. https://doi.org/10.1357/002224018826473290.