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Russian Forms: Race, Sex, And The Making Of Russian Literature, Fiona Bell Jan 2025

Russian Forms: Race, Sex, And The Making Of Russian Literature, Fiona Bell

Yale Graduate School of Arts and Sciences Dissertations

This dissertation argues that the elaboration of Russian racial imaginaries was coterminous with the construction of the Russian literary canon and Russian literary theory. Beginning with the global debates concerning the abolition of slavery and serfdom in the 1850s and concluding with the first wave of emigration from the Soviet Union in the 1920s, the dissertation demonstrates how canonical Russian authors—Ivan Turgenev, Fyodor Dostoevsky, Viktor Shklovsky, and others—wrote fiction that, in mobilizing the racial implications of intimacy, kinship, and heredity, articulated arguments about racial difference and the conceptual “fit” of “race” for the Russian Empire. Literary authors make arguments about …

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Bridging Behavior And Neural Activity: Neural Dynamics Leading To Self-Initiated And Task-Driven Movements, Yongxu Zhang Jan 2025

Bridging Behavior And Neural Activity: Neural Dynamics Leading To Self-Initiated And Task-Driven Movements, Yongxu Zhang

Yale Graduate School of Arts and Sciences Dissertations

Understanding how populations of neurons generate behavior remains a fundamental question in neuroscience. While single-neuron analyses have provided valuable insights, behavior emerges from the coordinated dynamics of large neural ensembles that evolve over time and across states. A major difficulty is that neural population activity is non-stationary: it exhibits temporal distributional shifts, transitions between distinct dynamical regimes, and modulation by external or inter-regional inputs. Advances in artificial intelligence offer new opportunities to address this challenge. Yet, conventional models, such as standard recurrent neural networks, often fail to capture such complexity, limiting both predictive performance and mechanistic interpretability. This motivates the …

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(1+1)D Topological Phases Enriched With Fusion Category Symmetries, Xinping Yang Jan 2025

(1+1)D Topological Phases Enriched With Fusion Category Symmetries, Xinping Yang

Yale Graduate School of Arts and Sciences Dissertations

Symmetry and its anomaly constrain a system's dynamics and provide a universal characterization of its behaviors. It serves as a powerful tool to understand exotic phases of matter, especially symmetry-protected topological (SPT) orders. The notion of generalized symmetries requires extending our previous understanding of topological phases to those enriched by fusion category symmetries, yet new mathematical formalism is needed to apply unitary fusion category symmetries to a microscopic system. This thesis starts with a model-independent description of an abstract spin chain viewed as a net of C*-algebras. From a microscopic SymTFT, categorical structures describing symmetry and symmetry charges can be …

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Impressions Contain Multitudes: Evaluative Inertia, Updating, And Lingering Impressions After Learning About Others, Arin Korkmaz Jan 2025

Impressions Contain Multitudes: Evaluative Inertia, Updating, And Lingering Impressions After Learning About Others, Arin Korkmaz

Yale Graduate School of Arts and Sciences Dissertations

People routinely learn new information that challenges their impressions of others, yet these impressions are not always updated. This dissertation investigates the conditions under which people retain or update their self-reported explicit and spontaneously activated implicit impressions in response to novel counterattitudinal information. It consists of three bodies of work showcasing the cognitive and contextual factors that lead to evaluative inertia or updating. First, it shows that people can make context-based inferences to retain their implicit impression of others, highlighting the role of higher processes in implicit impression updating. Second, it investigates what happens to initial impressions once they are …

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Outside The Workshop: Alternative Spaces Of U.S. Printmaking, 1935–1977, Michelle Donnelly Jan 2025

Outside The Workshop: Alternative Spaces Of U.S. Printmaking, 1935–1977, Michelle Donnelly

Yale Graduate School of Arts and Sciences Dissertations

The studio, the land, the camp, and the home are vital locations of print production. Yet scholars have overwhelmingly focused on prints made in the workshop, or an institutional facility stocked with specialized equipment and overseen by “master printers.” This dissertation investigates how women artists and artists of color expanded the parameters of printmaking outside the traditional site of the workshop from 1935 to 1977 in the United States. Each spatially organized chapter centers on one artist: David Hammons, Sari Dienes, Matsusaburo “George” Hibi, and Ruth Asawa. All four artists practiced what I call emplaced printmaking: an engagement with the …

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The Organization Of Autophagic Membranes And Proteins At The Phagophore Assembly Site, Devin Michael Fuller Jan 2025

The Organization Of Autophagic Membranes And Proteins At The Phagophore Assembly Site, Devin Michael Fuller

Yale Graduate School of Arts and Sciences Dissertations

Autophagosomes are transient organelles which grow from a seed vesicle to encapsulate a target cargo and subsequently fuse with the lysosome to degrade its contents. This process occurs rapidly and requires the concerted effort of a host of unique membranes and proteins in a complicated cascade, which I detail in chapter I. Deletion of the lipid transport proteins ATG2A and ATG2B results in the accumulation of most of the preceding autophagic membranes and proteins in a large compartment. The ATG2 DKO compartment is advantageous as a model for the phagophore assembly site (PAS) for the following reasons: it is not …

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Real-Time Minimum-Weight Parity Factor Decoders For Quantum Error Correction, Yue Wu Jan 2025

Real-Time Minimum-Weight Parity Factor Decoders For Quantum Error Correction, Yue Wu

Yale Graduate School of Arts and Sciences Dissertations

Quantum error correction (QEC) is essential for fault-tolerant quantum computing, but its practical deployment is limited by the complexity of decoding. Most-Likely-Error (MLE) decoding offers near-optimal accuracy but is computationally challenging, especially for general quantum Low-Density Parity-Check (qLDPC) codes. This dissertation develops a family of Minimum-Weight Parity Factor (MWPF) decoders that accelerate MLE decoding by exploiting the locality and parallelism inherent in the decoding problem. We first improve locality by designing decoders that operate on the sparse decoding hypergraph rather than the dense syndrome graph. This leads to an almost-linear average runtime and enables a generalization to hypergraphs with certifying …

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Visible-Light Mediated, Diastereoselective Epimerization Of Endocyclic, Exocyclic And Acyclic Amines, Maria Antonieta Vargas-Rivera Jan 2025

Visible-Light Mediated, Diastereoselective Epimerization Of Endocyclic, Exocyclic And Acyclic Amines, Maria Antonieta Vargas-Rivera

Yale Graduate School of Arts and Sciences Dissertations

Light-mediated stereochemical editing has become increasingly explored as a method for the stereoselective synthesis of compounds. This dissertation describes the work towards the stereoselective epimerization of amines. The first chapter describes the highly diastereoselective epimerization of endocyclic amines, which are commonly found in pharmaceuticals. The second chapter demonstrates the expansion of this light-mediated epimerization method to include exocyclic amines. Finally, chapter three details current advances towards the diastereoselective epimerization of acyclic amines.

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Incorporating Environmental Information Into Genetic Studies Of Psychiatric Disorders, Yue Hu Jan 2025

Incorporating Environmental Information Into Genetic Studies Of Psychiatric Disorders, Yue Hu

Yale Graduate School of Arts and Sciences Dissertations

Psychiatric disorders are among the most common diseases of humans, affecting a large number of individuals worldwide and contributing to a considerable burden of disease and disability. With a lifetime prevalence ranging from 5% to 17%, depression – characterized by a persistent low mood or loss of interest in activities for extended periods – is prominent amongst psychiatric disorders. Despite the availability of new medications developed over the past decade to treat depression, long-term treatment response remains disappointing; the risk of death by suicide is over 8-times national averages. Depression is multifactorial with both genetic and environmental factors, including demographic …

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Warm Life, Cold Stones: The Effigial Tomb In Late Medieval English Literature, Maia Ruth Béar Jan 2025

Warm Life, Cold Stones: The Effigial Tomb In Late Medieval English Literature, Maia Ruth Béar

Yale Graduate School of Arts and Sciences Dissertations

The effigial tomb is one of the defining features of Gothic sacred art. Tombs topped with grand effigies populated the churches, cathedrals, and chapels of late medieval England and many survive to this day. This dissertation explores the encounter with these tombs as represented in the literature of the period, in particular hagiography, romance, and narrative poetry. Although it literally demarcates the boundary between dead and living, the tomb is a powerful site of boundary-breaking in these texts at which the distinctions between life and death, flesh, and natural and artistic bodies are tested and often complicated. I consider various …

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Institutions For Online Governance: Field Experimental Studies Of Participation, Incentives, And Deliberation, Eliza Oak Jan 2025

Institutions For Online Governance: Field Experimental Studies Of Participation, Incentives, And Deliberation, Eliza Oak

Yale Graduate School of Arts and Sciences Dissertations

One of the oldest questions in human society is: What kind of government works best, and why? To date, studying the effects of governance design decisions has been empirically difficult. This dissertation addresses this challenge by examining decentralized governance in blockchain-based technology platforms, where decision-making power is distributed among users who collectively cast votes. These digital communities provide a unique laboratory for democracy research as they rapidly iterate on their institutional structures, experimenting with both traditional and novel governance strategies while confronting classic representation and accountability challenges. The blockchain context offers two crucial advantages for studying democratic processes, namely the …

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Advancing Neuroimaging Brain-Behavior Machine Learning Biomarkers, Brendan Adkinson Jan 2025

Advancing Neuroimaging Brain-Behavior Machine Learning Biomarkers, Brendan Adkinson

Yale Graduate School of Arts and Sciences Dissertations

Machine learning models trained on human neuroimaging data are increasingly used as tools for predicting individual behavioral phenotypes and enhancing precision medicine. However, multiple limitations hinder their current scientific and future clinical utility. In this dissertation, I address key challenges surrounding "brain-behavior" predictive model interpretability, generalization, and bias. In Chapters 2 and 3, I show that prevalent feature selection practices overlook features that are meaningful for both prediction and neurobiological interpretation. This suggests that prevailing approaches lead to feature overinterpretation and a misrepresentation of the neurobiological bases of brain-behavior associations. In Chapters 4 and 5, I demonstrate that brain-behavior predictions …

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Distrust Of Psychotherapy For Biologically Explained Mental Disorders: A Validation Of Beliefs Underlying This Distrust And Interventions To Mitigate This Distrust, Annalise Perricone Jan 2025

Distrust Of Psychotherapy For Biologically Explained Mental Disorders: A Validation Of Beliefs Underlying This Distrust And Interventions To Mitigate This Distrust, Annalise Perricone

Yale Graduate School of Arts and Sciences Dissertations

Lay and scientific communities alike increasingly attribute mental disorders to biological causes (e.g., genetic risk or neurobiological abnormalities). Biological explanations of mental disorders have some beneficial consequences, including reduced personal blame of individuals affected by such disorders. One adverse consequence, however, is that upon learning that a mental disorder has a biological etiology, people tend to show reduced trust in the effectiveness of psychotherapy. Given that the combination of psychotherapy and pharmacotherapy is often optimal for many mental disorders, reduced trust of psychotherapy could result in poorer clinical outcomes, if people elect not to receive such treatment. Although this distrust …

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Psychedelic Action On Dendritic Structure And Function, Neil K. Savalia Jan 2025

Psychedelic Action On Dendritic Structure And Function, Neil K. Savalia

Yale Graduate School of Arts and Sciences Dissertations

Psychedelics are amid a scientific renaissance driven by their therapeutic promise for mental illnesses. This dissertation examines the neural mechanisms that underlie the acute and long- term actions of psilocybin, a serotonergic psychedelic found in magic mushrooms and an emerging rapid antidepressant. Here we used cutting-edge in vivo techniques to investigate psilocybin's effects in the medial frontal cortex of mice, with a focus on the structure and function of dendrites. Four key findings emerged. First, a single treatment with psilocybin induces persistent dendritic spinogenesis (Chapter 1). The drug-evoked changes in neuronal structure and function varies for subtypes of excitatory pyramidal …

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Kinetic And Thermodynamic Analysis Of Enpp1, Marisa Mary Michalchik Jan 2025

Kinetic And Thermodynamic Analysis Of Enpp1, Marisa Mary Michalchik

Yale Graduate School of Arts and Sciences Dissertations

The Ectonucleotide Pyrophosphatase Phosphodiesterase (ENPP) family members are promiscuous extracellular enzymes that play central roles in human physiology via catalysis of nucleotide and lipid substrates, but remain poorly characterized at the biochemical level. The founding member, ENPP1, is a glycosylated transmembrane enzyme with an extracellular catalytic domain that degrades nucleotide substrates (ATP and cGAMP) into their respective nucleotide monophosphates, playing a key role in both the regulation of biomineralization and innate immune system activation. The ENPP1 ATPase is the major source of extracellular pyrophosphate (PPi), the main chemical inhibitor of calcium phosphate crystal formation in physiology. ENPP1 deficiency lowers systemic …

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Investigating The Sequence Requirements For Translation Initiation By Viral Internal Ribosome Entry Sites, Sabrina Gulli Grunseich Jan 2025

Investigating The Sequence Requirements For Translation Initiation By Viral Internal Ribosome Entry Sites, Sabrina Gulli Grunseich

Yale Graduate School of Arts and Sciences Dissertations

Protein synthesis is both essential and highly regulated. This process is complex and requires the concerted effort of many protein factors. Some viruses have evolved ways to co-opt host translation during initiation by using internal ribosome entry sites (IRESs). These structured RNAs allow the virus to bind to the host's ribosome in the absence of canonical requirements. This dissertation focuses on relating the sequence of viral IRES elements to their role in initiating translation. The Cricket Paralysis Virus (CrPV) IRES is short, uses a simple mechanism, and can function in diverse cell-free systems making it a useful tool to study …

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Bosonization And Fermionization Of Categorical Symmetries, Karan Bhatia Jan 2025

Bosonization And Fermionization Of Categorical Symmetries, Karan Bhatia

Yale Graduate School of Arts and Sciences Dissertations

The thesis investigates the processes of bosonization and fermionization within the framework of fusion category symmetries, which serve as the mathematical language for understanding topological phases of matter. We show that all fermionic fusion categories can be bosonized via a minimal braiding construction, providing a systematic method to relate fermionic and bosonic topological orders. Conversely, certain bosonic fusion categories that contain a Z_2 symmetry object can be fermionized using the same construction. However, a concrete obstruction arises when attempting to fermionize the remaining bosonic fusion categories, specifically those whose fusion rules involve two fixed points fusing into an odd number …

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Investigation Of How Long Noncoding Rna Pvt1 Regulates Myc Expression, Qiao Li Jan 2025

Investigation Of How Long Noncoding Rna Pvt1 Regulates Myc Expression, Qiao Li

Yale Graduate School of Arts and Sciences Dissertations

Long noncoding RNAs (lncRNAs) play essential roles in both physiological processes and disease, including cancer. A growing body of evidence positions lncRNAs as key regulators and biomarkers in tumorigenesis. Mechanistically, functional lncRNAs can regulate gene expression through epigenetic and transcriptional pathways, acting either via scaffold-like motifs that recruit regulatory complexes or through their abundance, which contributes to RNA-mediated feedback that modulates transcriptional condensates. Within the Plasmacytoma variant translocation 1 (Pvt1) locus, two alternative transcription start site isoforms have been identified: the constitutively expressed Pvt1a and the stress-inducible Pvt1b. While the precise functions of Pvt1a were not well understood, previous studies …

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Description’S Displacements: Writing Experience In Musil, Benjamin, And Bachmann, Aida Feng Jan 2025

Description’S Displacements: Writing Experience In Musil, Benjamin, And Bachmann, Aida Feng

Yale Graduate School of Arts and Sciences Dissertations

This dissertation unfolds the ways in which description emerged as an active site for reconfiguring human experience in the writing experiments of the 20th century. Description, as a procedure for presenting and arranging the phenomena of reality, typically constructs an epistemological realm of experience that progresses toward comprehension and internal consistency. Understood in this way, description mediates one kind of experiential reality while foreclosing others. This project enlarges description’s operative capabilities toward a presentational mode that does not merely re-describe the phenomenal objects in this reality. To do so, it foregrounds writers and thinkers who conversed directly with philosophical traditions …

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Aligning Water And Carbon Goals In Sustainable Transitions To Clean Energy, Yan Du Jan 2025

Aligning Water And Carbon Goals In Sustainable Transitions To Clean Energy, Yan Du

Yale Graduate School of Arts and Sciences Dissertations

As the global energy sector transitions toward cleaner and more sustainable sources, understanding the interdependencies between energy production and water resources becomes increasingly critical. Water is an essential input across a wide range of energy technologies – both conventional and renewable – impacting not only power generation efficiency but also broader dimensions of environmental sustainability, climate resilience, and resource equity. These interdependencies are central to the water-energy nexus, where decisions about one resource inevitably affect the other. In this context, assessing water-use efficiencies across diverse energy systems offers valuable insights into how societies can optimize resource allocation, minimize ecological impacts, …

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Development And Mechanistic Investigation Of First-Row Transition Metal-Catalyzed Alkene Functionalization Reactions, Juan Serviano Jan 2025

Development And Mechanistic Investigation Of First-Row Transition Metal-Catalyzed Alkene Functionalization Reactions, Juan Serviano

Yale Graduate School of Arts and Sciences Dissertations

This thesis describes the discovery and mechanistic studies of cobalt- and iron-catalyzed alkene hydrofunctionalization reactions. Chapter 1 introduces the fields of alkene hydrofunctionalization via metal-catalyzed hydrogen atom transfer (MHAT) and first-row transition metal-catalyzed alkene dicarbofunctionalization. Chapter 2 describes a method for intermolecular hydroalkoxylation and hydrocarboxylation of 2-azadienes using oxidative cobalt-catalyzed hydrogen atom transfer. The method generates 2-azaallyl cation equivalents under mild conditions to yield hemiaminal ethers and esters, and is chemoselective for 2-azadienes in the presence of other C=C double bonds. Chapter 3 describes the synthesis, characterization, and reactivity of an isolable alkylcobalt complex that models an intermediate proposed in …

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Functional Roles Of Subcellularly Localized Glycolytic Isoforms Of Glucose 6-Phosphate Isomerase, Ian Joseph Gonzalez Jan 2025

Functional Roles Of Subcellularly Localized Glycolytic Isoforms Of Glucose 6-Phosphate Isomerase, Ian Joseph Gonzalez

Yale Graduate School of Arts and Sciences Dissertations

While metabolic pathways are largely conserved across cells and organisms, tissues exhibit metabolic heterogeneity that tailors metabolism to their physiological demands. How the conserved pathways of metabolism achieve metabolic heterogeneity is incompletely understood, particularly in vivo. In this dissertation, I investigate the genetic requirement of glucose 6-phosphate isomerase (GPI-1), a conserved glycolytic enzyme that also regulates the pentose phosphate pathway (PPP). Using CRISPR-Cas9 genome editing, I found that gpi-1 knockout animals display germline defects consistent with impaired PPP, and somatic defects consistent with impaired glycolysis. I discovered that GPI-1 isoforms are differentially expressed and localized: GPI-1A is cytosolic in all …

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Uncovering Graphical Correlations For Spatial–Temporal And Sequential Modeling, Aosong Feng Jan 2025

Uncovering Graphical Correlations For Spatial–Temporal And Sequential Modeling, Aosong Feng

Yale Graduate School of Arts and Sciences Dissertations

Real-world signals—networks, sequences, and space-time measurements—are held together by structured correlations that are neither purely local nor purely global and that evolve over time. This dissertation shows how learning and exploiting such correlation structure leads to models that are accurate, scalable, and interpretable, and how the same structure can guide sampling and editing. We begin with spatial correlations on graphs, treating the observed topology as a prior and learning the interaction structure that truly governs nodes—jointly (i) modeling linear dependencies via trainable graph filters, (ii) capturing non-linear cues through similarity matching (kernel/attention affinities), and (iii) inferring latent edges to repair …

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Epidemiologic And Immunologic Characterization Of The Post-Acute Sequelae Of Covid-19, Christine Marie Miller Jan 2025

Epidemiologic And Immunologic Characterization Of The Post-Acute Sequelae Of Covid-19, Christine Marie Miller

Yale Graduate School of Arts and Sciences Dissertations

Since its emergence in late 2019, SARS-CoV-2 has infected over 15 million people—and the number continues to rise. The global impact of this novel coronavirus has been profound, reshaping not only public health infrastructure but also our understanding of human biology. The full extent of the virus’s effects on the immune system remains incompletely understood and will likely take years to fully unravel. What is already evident, however, is that SARS-CoV-2 uniquely modulates both innate and adaptive immunity, with consequences that span the developmental spectrum—from fetal and pediatric stages through adulthood. While many individuals recover without overt clinical sequelae, an …

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Glycolysis-Induced Acidification Links Mitochondrial Deficiency To Axon Degeneration, Hadas Dabas Jan 2025

Glycolysis-Induced Acidification Links Mitochondrial Deficiency To Axon Degeneration, Hadas Dabas

Yale Graduate School of Arts and Sciences Dissertations

Axons extend far from the neuronal soma and depend on local energy metabolism to sustain signaling and structural integrity. Mitochondria are normally abundant in axons, where they provide numerous utilities. In many neurodegenerative diseases, however, mitochondrial function or trafficking is impaired, but the mechanisms linking mitochondrial loss to axon degeneration remain unclear.In this dissertation, I use C. elegans mitochondrial trafficking mutants, in which axons completely lack mitochondria, to define the metabolic basis of degeneration. I find that glycolysis, typically viewed as a protective energy source, unexpectedly promotes axon breakdown. Elevated glycolytic flux in axons without mitochondria leads to accumulation of …

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Advanced Spectroscopic Techniques For Probing The Photophysical Properties Of Metal Halide Perovskites, Shunran Li Jan 2025

Advanced Spectroscopic Techniques For Probing The Photophysical Properties Of Metal Halide Perovskites, Shunran Li

Yale Graduate School of Arts and Sciences Dissertations

Metal halide perovskites (MHPs) have emerged as a versatile class of semiconductors with exceptional optoelectronic properties, yet their performance is intricately linked to their structural, dynamical, and photophysical characteristics. This dissertation presents a comprehensive investigation of MHPs—spanning three-dimensional, low-dimensional, and lead-free double perovskite compositions—using advanced spectroscopic techniques from the mid-infrared to X-rays. Steady-state optical spectroscopies are employed to probe ground-state properties and structure–property relationships, with emphasis on chiral 2D hybrid perovskites. A reflection-based methodology is developed to determine the intrinsic circular-polarization-dependent complex refractive index of single crystals, enabling quantitative separation of circular dichroism and birefringence. The formation of distinct spherulitic …

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Associations Between Mental Health Conditions And Adverse Pregnancy Outcomes Among Active-Duty Servicewomen, Laura Manzo Jan 2025

Associations Between Mental Health Conditions And Adverse Pregnancy Outcomes Among Active-Duty Servicewomen, Laura Manzo

Yale Graduate School of Arts and Sciences Dissertations

Active duty servicewomen (ADSW) have increased risk for mental health conditions compared to civilian women. Civilian research demonstrates that women with mental health conditions experience serious pregnancy complications at rates 50% higher than those without mental health conditions. Although mental health conditions are the leading underlying cause of maternal mortality, there is limited research on the prevalence of perinatal mental health conditions among active duty servicewomen (ADSWs) or their association with adverse pregnancy outcomes. This study aimed to explore associations of mental health conditions and adverse pregnancy outcomes in a population of ADSW. Methods Department of Defense Birth and Infant …

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‘Soñando En Un Futuro Mejor’: U.S. Empire, Racial Capitalism, And Garífuna And Afro-Caribbean Radicalism In Caribbean Honduras, 1920-1963, Cristian Jose Padilla Romero Jan 2025

‘Soñando En Un Futuro Mejor’: U.S. Empire, Racial Capitalism, And Garífuna And Afro-Caribbean Radicalism In Caribbean Honduras, 1920-1963, Cristian Jose Padilla Romero

Yale Graduate School of Arts and Sciences Dissertations

This dissertation argues that Afro-Caribbean and Garífuna radicals in 20th-century Honduras forged, at different times, radical, race-conscious, and sometimes anti-imperialist and nationalist politics that contested both U.S. corporate domination and the racialized exclusions of the U.S and Honduran nation-state. Focusing on the period between 1920 and 1963, it traces struggles across the Caribbean coastal cities of La Ceiba, Trujillo, Puerto Cortés, and Tela. By foregrounding Black and Indigenous working-class actors, like Centeno García and Alfonso Lacayo, it highlights how racial capitalism, labor radicalism, and anti-Black state and corporate repression intersected in Honduras’ banana economy. The stories of individuals like Centeno …

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Manufactured Enchantments: Technologizing The Self In The Twentieth-Century Americas, Isabel Ortiz Jan 2025

Manufactured Enchantments: Technologizing The Self In The Twentieth-Century Americas, Isabel Ortiz

Yale Graduate School of Arts and Sciences Dissertations

Manufactured Enchantments examines the way in which forms of enchantment worked at various sites—from culture industries, to self-help doxa, to esoteric and occult practices, to intellectual life—to construct an ideal self tailored to geopolitical violence in the U.S. and Latin America during the twentieth century. The dissertation studies five technologies—psychoanalysis, film, the rotoscope, the enneagram, and the tarot—that each suggested a self that could be stretched, modified, or altered to meet conditions of violence, uncertainty and precarity stemming from pre- and peri-Cold War U.S. imperial expansion efforts in the Americas. In each case study, I examine how the featured technology …

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Molecular Investigation Of Signaling Molecules Involved In Cerebrovascular Disorders, Kimberly Jean Vish Jan 2025

Molecular Investigation Of Signaling Molecules Involved In Cerebrovascular Disorders, Kimberly Jean Vish

Yale Graduate School of Arts and Sciences Dissertations

The most common forms of cerebrovascular malformations are brain arteriovenous malformations (AVM), often caused by genetic mutations in the EphB4-p120RasGAP signaling pathway, and cerebral cavernous malformations (CCM), often caused by genetic mutations in the CCM signaling pathway. These pathways are well studied, but there are clear deficiencies in the molecular level understanding of how signals are transduced. Relevant to AVM, the GTPase activating protein (GAP) for Ras, p120RasGAP, is necessary for downregulating Ras signaling during vascular development, and loss of its activity is associated with impaired cerebrovascular development. In my thesis, I investigate how p120RasGAP uses its Src-homology 2 (SH2) …

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