Digital Commons Network^™

The Funding Of The Irish Domestic Banking System During The Boom?, Philip R. Lane

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No abstract provided.

2015 Scorecard For Fannie Mae, Freddie Mac, And Common Securitization Solutions, United States: Federal Housing Finance Agency (Fhfa)

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Scorecard criteria outline of 1. Maintain, in a safe and sound manner, credit availability and foreclosure prevention activities for new and refinanced mortgages to foster liquid, efficient, competitive, and resilient national housing finance markets. 2. Reduce taxpayer risk through increasing the role of private capital in the mortgage market. 3. Build a new single-family securitization infrastructure for use by the Enterprises and adaptable for use by other participants in the secondary market in the future. [

Greece Prolongation Of The Guarantee Scheme And The Bond Loan Scheme For Credit Institutions In Greece, European Union: European Commission

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PUBLIC VERSIONThis document is made available for information purposes only.

Opinion Of Advocate General Cruz Villalon, Cruz Villaloz

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No abstract provided.

Prolongation Of The Guarantee Scheme And The Bond Loan Scheme For Credit Institutions In Greece, European Union: European Commission, Margrethe Vestager

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State aid SA.40030 (2014/N) – Greece Margrethe VESTAGER Member of the Commission

Порядок И Условия Размещения Имущественного Взноса Российской Федерации В Имущество Государственной Корпорации «Агентство По Страхованию Вкладов» В Субординированные Обязательства И Привилегированные Акции Банков, Russian Federation: Deposit Insurance Agency

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No abstract provided.

Stabilising And Healing The Irish Banking System: Policy Lessons, Dirk Schoenmaker

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Lessons from Ireland's recovery from the Bank-Sovereign Loop. Paper prepared for the CBI-CEPR-IMF Conference.

The Impact Of Liquidity Regulation On Banks, Ryan N. Banerjee, Hitoshi Mio

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No abstract provided.

Documents Have Been Submitted To The Fcmc For Obtaining A Significant Participation Permit In The Bank Citadele, Citadele

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No abstract provided.

Decision (Eu) 2015/5 Of The European Central Bank Of 19 November 2014 On The Implementation Of The Asset-Backed Securities Purchase Programme, European Central Bank (Ecb)

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Most recent decision renewing the ABSPP and setting eligibility criteria

Hall Of Mirrors: The Great Depression, The Great Recession, And The Uses-And Misuses-Of History, Barry Eichengreen

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No abstract provided.

Skin Cancer Outcomes As A Function Of Referral Reason In Solid Organ Transplant Recipients, Sakil Chundydyal

Yale Medicine Thesis Digital Library

SKIN CANCER OUTCOMES AS A FUNCTION OF REFERRAL REASON IN SOLID ORGAN TRANSPLANT RECIPIENTS. Sakil Chundydyal, Fang-Yong Li, Oscar R. Colegio, Department of Dermatology, Yale School of Medicine, New Haven, CT.

Purpose of study: The purpose of this study is to examine the reason for referral of Organ Transplant Recipients (OTR) to a specialized dermatology clinic as a predictor of Non Melanoma Skin Cancer outcomes in those patients.

Methods: A retrospective chart study was conducted using the records for current OTR patients referred to a specialized transplant dermatology clinic from 1991 to 2012. The data reasons for referral as well …

Evaluation Of A 5-Group Classification System For Severe Sepsis By Ed Vasopressor Use And Initial Serum Lactate, Kai Swenson

Yale Medicine Thesis Digital Library

HYPOTHESIS AND SPECIFIC AIMS: The aim of this study is to characterize the incidence and outcomes of various groups within a novel classification system of severe sepsis and septic shock, for the purpose of informing more accurate risk prediction in the proximal phases of care. Our primary hypothesis is that an early classification system of septic patients categorized by organ dysfunction, initial emergency department (ED) serum lactate, and ED vasopressor utilization will offer accurate mortality prognostication in patients with severe sepsis and septic shock.

METHODS: We performed a retrospective analysis of a prospectively- gathered registry of severe sepsis and septic …

Unshrouding Effects On Demand For A Costly Add-On: Evidence From Bank Overdrafts In Turkey, Sule Alan, Mehmet Cemalcilar, Dean Karlan, Jonathan Zinman

Discussion Papers

No abstract provided.

The Catch-22 Of External Validity In The Context Of Constraints To Firm Growth, Greg Fischer, Dean Karlan

Discussion Papers

No abstract provided.

A Composite Vertical Current Spectrum For Strongly And Weakly Stratified Seas And Oceans, Hans Van Haren

Journal of Marine Research

An overall frequency (σ) spectrum φ_w(σ, N, f_h) is composed for vertical current (w) observations from ocean areas with different stratifications represented by large, 100 m scale buoyancy frequency N. The horizontal Coriolis parameter is denoted by f_h. In the open Atlantic Ocean, the relatively strong horizontal layering in density supports the φ_w that is found in semiequilibrium under the degradation of the lowest internal wave mode. This φ_w is not constant with frequency; however, its variance increases between σ = f and its peak near σ = (0.5 …

Species Diversity Patterns Of Marine Plankton And Benthos In Chinese Bays: Baseline Prior To Large-Scale Development, Weiwei Yu, Bin Chen, Paolo F. Ricci, Luoping Zhang, Jianguo Du, Zhiyuan Ma

Journal of Marine Research

More than 28,000 marine species have been recorded in China, which accounts for approximately 10% of all marine organisms in the world and plays a potentially important role in protecting global marine biodiversity. However, knowledge of marine biodiversity patterns in China is limited, and in particular, no comparative diversity analysis has been carried out for Chinese bays. In this study, national-scale species diversity patterns of coastal bays were examined on the basis of investigations for approximately 81 bays throughout the entire Chinese coastline in the 1980s and the early 1990s, revealing the baseline of diversity patterns prior to large-scale development. …

Intertidal Percolation Through Beach Sands As A Source Of 224,223 Ra To Long Island Sound, New York, And Connecticut, United States, Henry Bokuniewicz, J. Kirk Cochran, Jordi Garcia-Orellana, Valenti Rodellas, John Wallace Daniel, Christina Heilbrun

Journal of Marine Research

Along tidal coasts, seawater circulated through the intertidal beach contributes to submarine groundwater discharge (SGD) and its associated geochemical signature. The short-lived radium isotopes, ²²³Ra (half-life = 11.4 d) and ²²⁴Ra (half-life = 3.66 d), were used to quantify this component of SGD in a large estuary, Long Island Sound (LIS), New York, United States. The tide is semidiurnal with a range of approximately 2 m. Concentrations in beach pore waters ranged from 97 to 678 disintegrations per minute (dpm) ²²⁴Ra 100 L^–1, whereas concentrations in open coastal waters ranged from approximately 12 to 69 …

Nitrogen Substrate–Dependent Nitrous Oxide Cycling In Salt Marsh Sediments, Qixing Ji, Andrew R. Babbin, Xuefeng Peng, Jennifer L. Bowen, Bess B. Ward

Journal of Marine Research

Nitrous oxide (N₂O) is important to Earth's climate because it is a strong absorber of radiation and an important ozone depletion agent. Increasing anthropogenic nitrogen input into the marine environment, especially to coastal waters, has led to increasing N₂O emissions. Identifying the nitrogen compounds that serve as substrates for N₂O production in coastal waters reveals important pathways and helps us understand their control by environmental factors. In this study, sediments were collected from a long-term fertilization site in Great Sippewissett Marsh, Falmouth, Massachusetts. The ¹⁵N tracer incubation time course experiments were conducted and …

Distinguishing Turbulent Overturns In High-Sampling-Rate Moored Thermistor String Observations, Hans Van Haren, Louis Gostiaux

Journal of Marine Research

Turbulent overturns are distinguished from salinity-compensated intrusions in high-resolution moored thermistor string observations. The buoyancy frequency N is used to make the time dimensionless, "t*." This results in a primary, visual means to easily compare the duration of overturns with N, the natural frequency that separates internal waves from turbulent overturns. As a secondary means, the shapes of overturns are investigated. Above various sloping topography between 500 and 1,000 m water depth where the buoyancy period varies between ∼1,300 and 2,600 s, vertical overturns of ∼40 m last Δt* =0.2–0.4. This corresponds with the timescale …

A Quantitative Analysis Of The Relationship Between Medicare Payment And Service Volume For Cataract, Glaucoma, And Retina Procedures From 2005 To 2009, Dan Ang Gong

Yale Medicine Thesis Digital Library

The purpose of this study was to evaluate the extent to which changes in the Medicare Physician Fee Schedule influence the volume and intensity of ophthalmic services for cataract, glaucoma, and retina procedures.

We conducted a retrospective, longitudinal analysis using a fixed-effects regression model of Medicare Part B carriers representing all fifty states and the District of Columbia from 2005 to 2009 to calculate Medicare payment-volume elasticities, defined as the percent change in Medicare service volume per 1% change in Medicare payment, for twelve procedures: non-complex and complex cataract surgery (CPT 66984 and CPT 66982), laser trabeculoplasty (CPT 65855), trabeculectomy …

Improving Human Health By Increasing Access To Natural Areas: Linking Research To Action At Scale, Bradford S. Gentry, Julia E. Anderson, David R. Krause, W. Colby Tucker, Karen A. Tuddenham

Yale School of the Environment Publications Series

Report of the 2014 Berkley Workshop

Held at the Wingspread Conference Center, Johnson Foundation, Racine, Wisconsin - June 2014

The Impact Of Donor And Recipient Renal Dysfunction On Cardiac Allograft Survival: Insights Into Reno-Cardiac Interactions, Olga Laur

Yale Medicine Thesis Digital Library

Aims: Renal dysfunction (RD) is a potent risk factor for death in patients with cardiovascular disease. This relationship may be causal since experimentally induced RD produces findings such as myocardial necrosis and apoptosis in animals. Cardiac transplantation provides an opportunity to investigate this hypothesis in humans; if direct myocardial damage is principally responsible for the substantial risk associated with RD, this risk should be transferable from a donor with RD to the recipient via the allograft.

Methods and Results: Cardiac transplantations from the UNOS registry were studied (n=23,056). RD was defined as an estimated glomerular filtration rate < 60 ml/min/1.73m2. RD was present in 17.9% of donors and 39.4% of recipients. Donor characteristics that could theoretically result in myocardial damage such as longer ischemic time, older age, diabetes, hypertension, and cigarette use were associated with increased graft failure (p≤0.007 for all). However, donor RD was not associated with graft failure (age-adjusted HR=1.00, 95% CI 0.94-1.07, p=0.92). Moreover, in recipients with RD the highest risk for graft failure occurred immediately post-transplant (0-30 day HR=1.8, 95% CI 1.54-2.02, p<0.001) with subsequent attenuation of the risk over time (30-365 day HR=0.92, 95% CI 0.77-1.09, p=0.33).

Conclusion: The risk …

Positive Margins And Other Factors Associated With Survival In Early Stage Oral Cavity Squamous Cell Cancer: Prognostic Impact And Quality Measure, Alexander Leo Luryi

Yale Medicine Thesis Digital Library

Objective: The aim of this work was to determine the prognostic impact of positive margins in early oral cavity squamous cell cancer and evaluate the utility of positive margin incidence as a surgical quality measure.

Study design and setting: Retrospective analysis of the National Cancer Data Base

Subjects and methods: Patients with oral cavity squamous cell cancer diagnosed between 1998 and 2011 who were treated with surgical resection were sampled. Univariate and multivariate analyses of overall survival and incidence of positive margins were performed.

Results: A total of 6,830 patients were included in the survival analysis. Overall survival at 5-years …

Cholinergic Neurotransmission In Partial Limbic Seizures, Geoffrey Liu

Yale Medicine Thesis Digital Library

Partial limbic seizures impair consciousness, but the mechanism of impairment is not known. Most views hold that structures necessary for consciousness are disrupted by overexcitation from spread of seizure activity. Against this view, we hypothesize that partial limbic seizures cause pathological long-range inhibition of cortical activity. Using a rat model for partial limbic seizures, we demonstrate BOLD fMRI signal increases in the hippocampal seizure focus, but decreases in arousal promoting regions such as the thalamus and midbrain tegmentum. Second, direct single unit recordings from cholinergic neurons in two arousal nuclei, the basal forebrain and the pedunculopontine tegmental nuclei, demonstrate suppressed …

Optimizing The Melanoma Tropism Of Mouse Parvovirus 1a For Use As A Viral Immunotherapy Vector, Matthew Marr

Yale Medicine Thesis Digital Library

Melanoma is a prevalent, deadly disease with poor outcomes following metastasis. It is an immunogenic cancer with many unique tumor antigens, but the tumor microenvironment inhibits the immune system. Current monoclonal antibody treatment has been shown to be beneficial in metastatic melanoma by blocking inhibitory immune signals such as PD-1 or CTLA-4. The expression of immunostimulatory proteins such as B7.1 by tumor cells could provide additional immune targeting. Viral vectors based on the parvovirus genome could efficiently and selectively express B7.1 in melanoma cells, such that they become competent to directly activate cognate T cells. Once activated, T cells will …

Incidence Of And Risk Factors For Anthracycline- And Trastuzumab-Associated Cardiotoxicity, Esther Park

Yale Medicine Thesis Digital Library

A major limitation of some of the most effective breast cancer (BC) therapies is the development of heart failure or left ventricular dysfunction. However, knowledge of the risk factors for development of cardiotoxicity from use of current standard BC therapies is incomplete. This study aimed to determine the incidence and predictors of cardiotoxicity associated with anthracycline and trastuzumab treatment.

We retrospectively identified patients in the Yale Nuclear Cardiology database who were diagnosed with BC between 2003 and 2013. The patients were grouped into cohorts based on whether they had received an anthracycline or trastuzumab as a part of their treatment …

T Cell Calcium Flux And Clonal Proliferation Report On Antigen-Specific Myeloid Cell Encounters, Nour Kibbi

Yale Medicine Thesis Digital Library

Despite its clinical success, the mechanism underlying extracorporeal photopheresis (ECP) is not well understood, however, the plate-passage (PP) step appears integral to generating activated monocytes. In the first part of the project, we developed a functional assay to evaluate the efficacy of plate-passed myeloid cells (PPM) compared with freshly isolated, unstimulated monocytes (UM) and conventional dendritic cells derived from blood monocytes cultured with GM-CSF/IL4 (DC). Each of these three antigen presenting cell (APC) was co-cultured with purified, autologous CD8 cells, with or without CD4 cells. Cultures were carried out using melanoma antigen MART-1 "long peptide (LP)," a 25-amino acid peptide …

Isolation Of Bone Marrow Mononuclear Cells For Fabrication Of Tissue-Engineered Vascular Grafts: Evaluation Of Two Methods, Paul S. Bagi

Yale Medicine Thesis Digital Library

Objective: Tissue engineered vascular grafts (TEVGs) are useful in the surgical treatment of congenital heart defects. The development of TEVGs requires seeding of scaffolds composed of biodegradable polymers with bone marrow-derived mononuclear cells (BM-MNCs). The most common method used to isolate BM-MNCs involves density centrifugation in Ficoll. This process requires an International Organization for Standardization (ISO) class 7 clean room, is labor intensive, time intensive, and susceptible to operator variability. A recently developed filtration-based method for BM-MNC isolation uses a closed, sterile, and disposable system that removes the need for a clean room, decreases processing time, and is operator-independent. This …

Smarcb1-Mutant Intracranial Meningiomas: A Distinct Subtype Of Nf2-Mutant Tumors, Jacob Francis Baranoski

Yale Medicine Thesis Digital Library

Meningiomas are the most common central nervous system primary tumors. Mutations in the tumor suppressor gene Neurofibromin 2 (NF2), located on chromosome 22 (Chr22), are present in 40-50% of sporadic meningiomas. In a subset of non-NF2-mutant meningiomas, recent studies have identified tumorigenesis driver mutations in the genes TRAF7, AKT1, KLF4, and SMO. However, the genetic basis for the marked clinical and histological heterogeneity that exists among NF2-mutant/Chr22-loss meningiomas remains to be established. In this study, we utilized next-generation sequencing techniques to identify and screen a large cohort of NF2-mutant/Chr22-loss meningiomas for concurrent co-driver mutations in novel genes that may contribute …